Read by QxMD icon Read


Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Kazunori Nishizaki
OBJECTIVES: We reviewed surgical results of canal wall-down tympanoplasty (CWDT) with soft posterior meatal wall reconstruction (SWR) for acquired cholesteatoma (AC), and identified factors associated with surgical outcomes. METHODS: Results from 119 ears with AC (pars flaccida, n = 99; pars tensa, n = 20) that underwent CWDT with SWR were retrospectively reviewed. We defined postoperative balloon-like retraction (PBR) with web formation, which needed reoperation to clean accumulated cerumen, as postoperative deep retraction pocket (PDRP)...
March 8, 2018: Acta Oto-laryngologica
Sanne Katherina Meles, Remco J Renken, Annette Janzen, David Vadasz, Marco Pagani, Dario Arnaldi, Silvia Morbelli, Flavio Nobili, Geert Mayer, Klaus L Leenders, Wolfgang H O Oertel
Rationale: Idiopathic REM sleep behavior disorder (iRBD) is considered a prodromal stage of Parkinson's disease (PD) and other Lewy-body disorders. Spatial covariance analysis of [18 F]-Fluorodeoxyglucose Positron Emission Tomography (18 F-FDG-PET) data has disclosed a specific brain pattern of altered glucose metabolism in PD. In this study, we identify the metabolic pattern underlying iRBD and compare it to the known PD pattern. To understand the relevance of the iRBD pattern to disease progression, we study the expression of the iRBD pattern in de novo PD patients...
February 23, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Philip W Lam, David M Naimark, Jerome A Leis
Peritoneal dialysis-related peritonitis (PDRP) is a commonly encountered complication in patients undergoing peritoneal dialysis (PD). Establishing the causative organism in PDRP allows for targeted antibiotic selection, helps to guide duration of therapy, and determines the need for catheter removal. Microbacterium is a genus of aerobic gram-positive bacilli found in the environment. Its detection in clinical isolates has increased owing to improved microbiology diagnostics. We present a case of PDRP due to M...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Chris J Chastain, Lisa M Baird, Mitchell T Walker, Charles C Bergman, Gulnara T Novbatova, Candida S Mamani-Quispe, Jim N Burnell
In C4 plants, the pyruvate phosphate dikinase regulatory protein (PDRP) regulates the C4-pathway enzyme pyruvate phosphate dikinase (PPDK) in response to changes in incident light-intensity. In maize (Zea mays) leaves, two distinct isoforms of PDRP are expressed, ZmPDRP1 and ZmPDRP2. The properties and C4-function of ZmPDRP1 isoform are well understood. However, the PDRP2 isoform has only recently been identified and its properties and function(s) in maize leaves are unknown. We therefore initiated an investigation into the maize PDRP2 isoform by performing a side-by-side comparison of its enzyme properties and cell-specific distribution with PDRP1...
December 21, 2017: Journal of Experimental Botany
Barney Wharam, Laura Weldon, Mark Viney
BACKGROUND: Animals use information from their environment to make decisions, ultimately to maximize their fitness. The nematode C. elegans has a pheromone signalling system, which hitherto has principally been thought to be used by worms in deciding whether or not to arrest their development as larvae. Recent studies have suggested that this pheromone can have other roles in the C. elegans life cycle. RESULTS: Here we demonstrate a new role for the C. elegans pheromone, showing that it accelerates hermaphrodites' reproductive rate, a phenomenon which we call pheromone-dependent reproductive plasticity (PDRP)...
August 22, 2017: BMC Evolutionary Biology
Petra Tomše, Luka Jensterle, Marko Grmek, Katja Zaletel, Zvezdan Pirtošek, Vijay Dhawan, Shichun Peng, David Eidelberg, Yilong Ma, Maja Trošt
PURPOSE: The purpose of this study was to identify the specific metabolic brain pattern characteristic for Parkinson's disease (PD): Parkinson's disease-related pattern (PDRP), using network analysis of [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) brain images in a cohort of Slovenian PD patients. METHODS: Twenty PD patients (age 70.1 ± 7.8 years, Movement Disorder Society Unified Parkinson's Disease Motor Rating Scale (MDS-UPDRS-III) 38.3 ± 12...
May 2017: Neuroradiology
Chunyan Cao, Huiwei Zhang, Dianyou Li, Shikun Zhan, Jing Zhang, Xiaoxiao Zhang, Chuantao Zuo, Bomin Sun
BACKGROUND: Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD). OBJECTIVES: To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using 18F-fluorodeoxyglucose (FDG) and positron emission tomography (PET). METHODS: Resting-state brain 18F-FDG PET imaging was performed for 8 PD patients before surgery and also 1 year after STN DBS treatment; changes in regional glucose metabolism were identified...
2017: Stereotactic and Functional Neurosurgery
Petra Tomše, Luka Jensterle, Sebastijan Rep, Marko Grmek, Katja Zaletel, David Eidelberg, Vijay Dhawan, Yilong Ma, Maja Trošt
PURPOSE: To evaluate the reproducibility of the expression of Parkinson's Disease Related Pattern (PDRP) across multiple sets of 18F-FDG-PET brain images reconstructed with different reconstruction algorithms. METHODS: 18F-FDG-PET brain imaging was performed in two independent cohorts of Parkinson's disease (PD) patients and normal controls (NC). Slovenian cohort (20 PD patients, 20 NC) was scanned with Siemens Biograph mCT camera and reconstructed using FBP, FBP+TOF, OSEM, OSEM+TOF, OSEM+PSF and OSEM+PSF+TOF...
September 2017: Physica Medica: PM
Sheryl A Zelenitsky, Jacy Howarth, Philippe Lagacé-Wiens, Christie Sathianathan, Robert Ariano, Christine Davis, Mauro Verrelli
♦ BACKGROUND: Information related to the microbiology of peritonitis is critical to the optimal management of patients receiving peritoneal dialysis (PD). The goal was to characterize the microbiological etiology and antimicrobial susceptibilities of PD-related peritonitis (PDRP) from 2005 to 2014, inclusive. ♦ METHODS: The distribution of organisms in culture-positive PDRP was described for new episodes and relapse infections, and further detailed for monomicrobial and polymicrobial peritonitis. Annual and overall rates of PDRP were also characterized...
March 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Paul J Mattis, Martin Niethammer, Wataru Sako, Chris C Tang, Amir Nazem, Marc L Gordon, Vicky Brandt, Vijay Dhawan, David Eidelberg
OBJECTIVE: To determine whether cognitive impairment in Parkinson disease (PD) and Alzheimer disease (AD) derives from the same network pathology. METHODS: We analyzed (18)F-fluorodeoxyglucose PET scans from 40 patients with AD and 40 age-matched healthy controls from the Alzheimer's Disease Neuroimaging Initiative and scanned an additional 10 patients with AD and 10 healthy controls at The Feinstein Institute for Medical Research to derive an AD-related metabolic pattern (ADRP) analogous to our previously established PD cognition-related pattern (PDCP) and PD motor-related pattern (PDRP)...
November 1, 2016: Neurology
Laure Peyro Saint Paul, Maxence Ficheux, Danièle Debruyne, Magalie Loilier, Nicolas Bouvier, Rémy Morello, Jean-Jacques Parienti, Renaud Verdon, François Fournel, Vincent Cattoir, Thierry Lobbedez
♦ BACKGROUND: Antibiotics are preferentially delivered via the peritoneal route to treat peritoneal dialysis-related peritonitis (PDRP) to ensure that maximal concentrations are delivered to the site of infection. Our study focused on the pharmacokinetics of daptomycin (DAP) administered via the intraperitoneal (IP) route in patients with PDRP. ♦ METHODS: According to the DaptoDP protocol (Clinical Trial No. 2012-005699-33), IP DAP was administered daily, i.e., during the 6-h Nutrineal (Baxter Healthcare Corporation, Deerfield, IL, USA) dwell time period, for 14 days, in addition to administration of the antibiotics used for the usual care of patients with PDRP...
January 2, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Wei-Xi Xiong, Yi-Min Sun, Rong-Yuan Guan, Su-Shan Luo, Chen Chen, Yu An, Jian Wang, Jian-Jun Wu
The missense mutation A53T of alpha-synuclein gene (SNCA) was reported to be a rare but definite cause of sporadic and familial Parkinson disease (PD). It seemed to be restricted geographically in Greece and Italy. We aimed to identify the SNCA mutations in a Chinese PD cohort. Ninety-one early onset PD patients or familial PD probands were collected consecutively for the screening of PD-related genes. The genetic analysis was carried out by target sequencing of the exons and the corresponding flanking regions of the PD-related genes using Illumina HiSeq 2000 sequencer and further confirmed by Sanger sequencing or restriction fragment length polymorphism...
October 2016: Journal of Neurology
Hoang-Ton Nguyen, Eelco van Duinkerken, Frank D Verbraak, Bettine C P Polak, Peter J Ringens, Michaela Diamant, Annette C Moll
BACKGROUND: Diabetic retinopathy (DRP) is a common microvascular complication seen in patients with type 1 diabetes mellitus (T1DM). The effects of T1DM and concomitant (proliferative) DRP on retinal blood flow are currently unclear. Therefore, we measured retinal vascular blood flow in T1DM patients with and without DRP and non-diabetic controls. We further assessed the acute effects of panretinal photocoagulation on retinal microvascular bloodflow in eight patients with diabetes. METHODS: Thirty-three T1DM patients with proliferative DRP, previously treated with panretinal photocoagulation (pDRP), 11 T1DM patients with untreated non-proliferative retinopathy (npDRP) and 32 T1DM patients without DRP (nDRP) were compared with 44 non-diabetic gender-matched controls...
May 26, 2016: BMC Endocrine Disorders
Lun Jiang, Yi-Bo Chen, Jiangge Zheng, Zhenhang Chen, Yujie Liu, Ye Tao, Wei Wu, Zhongzhou Chen, Bai-Chen Wang
Pyruvate orthophosphate dikinase (PPDK) is one of the most important enzymes in C4 photosynthesis. PPDK regulatory protein (PDRP) regulates the inorganic phosphate-dependent activation and ADP-dependent inactivation of PPDK by reversible phosphorylation. PDRP shares no significant sequence similarity with other protein kinases or phosphatases. To investigate the molecular mechanism by which PDRP carries out its dual and competing activities, we determined the crystal structure of PDRP from maize (Zea mays)...
February 2016: Plant Physiology
Florian Holtbernd, Yilong Ma, Shichun Peng, Frank Schwartz, Lars Timmermann, Lutz Kracht, Gereon R Fink, Chris C Tang, David Eidelberg, Carsten Eggers
Parkinson's disease (PD) is associated with distinct metabolic covariance patterns that relate to the motor and cognitive manifestations of the disorder. It is not known, however, how the expression of these patterns relates to measurements of nigrostriatal dopaminergic activity from the same individuals. To explore these associations, we studied 106 PD subjects who underwent cerebral PET with both (18) F-fluorodeoxyglucose (FDG) and (18) F-fluoro-L-dopa (FDOPA). Expression values for the PD motor- and cognition-related metabolic patterns (PDRP and PDCP, respectively) were computed for each subject; these measures were correlated with FDOPA uptake on a voxel-by-voxel basis...
September 2015: Human Brain Mapping
Min-Hua Tseng, Chih-Jen Cheng, Chih-Chien Sung, Yu-Ching Chou, Pauling Chu, Giien Shuen Chen, Shih-Hua Lin
BACKGROUND: Hyponatremia is known to be a marker of poor prognosis in many clinical conditions. The association between hyponatremia and clinical outcomes in peritoneal dialysis-related peritonitis (PDRP) has not been studied. We evaluated the association between hyponatremia and clinical parameters of patients with PDRP. METHODS: We conducted a retrospective analysis of medical records of patients with PDRP admitted to a medical center in the period 2004-2011. Patients with serum Na+ <130 mEq/L and ≥ 130 mEq/L at admission were divided into hyponatremic and normonatremic groups, respectively...
2014: BMC Nephrology
Yi-Bo Chen, Tian-Cong Lu, Hong-Xia Wang, Jie Shen, Tian-Tian Bu, Qing Chao, Zhi-Fang Gao, Xin-Guang Zhu, Yue-Feng Wang, Bai-Chen Wang
In C4 plants, pyruvate orthophosphate dikinase (PPDK) activity is tightly dark/light regulated by reversible phosphorylation of an active-site threonine (Thr) residue; this process is catalyzed by PPDK regulatory protein (PDRP). Phosphorylation and dephosphorylation of PPDK lead to its inactivation and activation, respectively. Here, we show that light intensity rather than the light/dark transition regulates PPDK activity by modulating the reversible phosphorylation at Thr-527 (previously termed Thr-456) of PPDK in maize (Zea mays)...
June 2014: Plant Physiology
Florian Holtbernd, Jean-François Gagnon, Ron B Postuma, Yilong Ma, Chris C Tang, Andrew Feigin, Vijay Dhawan, Mélanie Vendette, Jean-Paul Soucy, David Eidelberg, Jacques Montplaisir
OBJECTIVE: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. METHODS: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8...
February 18, 2014: Neurology
Orhan Ates, Habip Bilen, Sadullah Keles, H Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Ondaş, L Can Pınar, Mustafa Civelekler, Orhan Baykal
AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration. METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50). The control group was consist of healthy individuals (n=50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups. RESULTS: Ubiquinone-10 (Coenzyme Q10) levels in PDRP and control subjects are 3.81±1...
2013: International Journal of Ophthalmology
Shichun Peng, Yilong Ma, Phoebe G Spetsieris, Paul Mattis, Andrew Feigin, Vijay Dhawan, David Eidelberg
To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression in individual subjects can discriminate patients from controls or predict behavioral measures. The technique may depend on differences in spatial normalization algorithms and brain imaging systems...
May 2014: Human Brain Mapping
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"