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https://www.readbyqxmd.com/read/28531943/recent-trends-in-zikv-research-a-step-away-from-cure
#1
REVIEW
Aftab Alam, Nikhat Imam, Anam Farooqui, Shahnawaz Ali, Md Zubbair Malik, Romana Ishrat
Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus has emerged as a potential threat to human health worldwide. Consequences of vertical infections includes microcephaly with brain and eye anomalies, and adult infections includes Guillain-Barrésyndrome (GBS), brain ischemia, myelitis and meningoencephalitis. To develop a better treatment, many efforts are being made, like drug-repurposing concept for FDA-approved drugs for antiviral activity are screened against ZikV infection and emerging as a promising alternative to expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and AGS-v vaccines have been designed and in under clinical trial phases...
May 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28530022/development-of-a-reverse-transcription-quantitative-polymerase-chain-reaction-based-assay-for-broad-coverage-detection-of-african-and-asian-zika-virus-lineages
#2
Yang Yang, Gary Wong, Baoguo Ye, Shihua Li, Shanqin Li, Haixia Zheng, Qiang Wang, Mifang Liang, George F Gao, Lei Liu, Yingxia Liu, Yuhai Bi
The Zika virus (ZIKV) is an arbovirus that has spread rapidly worldwide within recent times. There is accumulating evidence that associates ZIKV infections with Guillain-Barré Syndrome (GBS) and microcephaly in humans. The ZIKV is genetically diverse and can be separated into Asian and African lineages. A rapid, sensitive, and specific assay is needed for the detection of ZIKV across various pandemic regions. So far, the available primers and probes do not cover the genetic diversity and geographic distribution of all ZIKV strains...
May 19, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28527161/prognostic-indicators-of-response-to-plasmapheresis-in-patients-of-guillain-barre-syndrome
#3
H B Prasad, R T Borse, A N Avate, Assistant Professor In Medicine Palasdeokar
INTRODUCTION: Plasmapheresis is an important modality for the treatment of GBS. Moreover the response to this treatment modality is not same in all cases. We therefore studied the various prognostic indicators of response to plasmapheresis in patients of Guillain Barre Syndrome. MATERIAL AND METHODS: 40 patients were included in the study. Thorough clinical examination was done. Nerve conduction was done to find out the type of neuropathy. All were then given plasmapheresis...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28526729/phased-genotyping-by-sequencing-enhances-analysis-of-genetic-diversity-and-reveals-divergent-copy-number-variants-in-maize
#4
Heather Manching, Subhajit Sengupta, Keith R Hopper, Shawn W Polson, Yuan Ji, Randall J Wisser
High-throughput sequencing of reduced representation genomic libraries has ushered in an era of genotyping-by-sequencing (GBS), where genome-wide genotype data can be obtained for nearly any species. However, there remains a need for imputation-free GBS methods for genotyping large samples taken from heterogeneous populations of heterozygous individuals. This requires a number of issues encountered with GBS be considered, including the sequencing of non-overlapping sets of loci across multiple GBS libraries, a common missing data problem that results in low call rates for markers per individual, and a tendency for applicability only in inbred line samples with sufficient linkage disequilibrium for accurate imputation...
May 19, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28523231/association-of-anti-gangliosides-antibodies-and-anti-cmv-antibodies-in-guillain-barr%C3%A3-syndrome
#5
Lijuan Wang, Chunqing Shao, Chunjiao Yang, Xixiong Kang, Guojun Zhang
INTRODUCTION: Numerous types of infection were closely related to GBS, mainly including Campylobacter jejuni, Cytomegalovirus, which may lead to the production of anti-gangliosides antibodies (AGA). Currently, although there are increased studies on the AGA and a few studies of anti-CMV antibodies in GBS, the association between them remains poorly documented. Therefore, our research aims to analyze the correlation of anti-CMV antibodies and AGA in GBS. METHODS: A total of 29 patients with GBS were enrolled in this study...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28521265/optimizing-the-electrodiagnostic-accuracy-in-guillain-barr%C3%A3-syndrome-subtypes-criteria-sets-and-sparse-linear-discriminant-analysis
#6
Antonino Uncini, Luigi Ippoliti, Nortina Shahrizaila, Yukari Sekiguchi, Satoshi Kuwabara
OBJECTIVE: To optimize the electrodiagnosis of Guillain-Barré syndrome (GBS) subtypes at first study. METHODS: The reference electrodiagnosis was obtained in 53 demyelinating and 45 axonal GBS patients on the basis of two serial studies and results of anti-ganglioside antibodies assay. We retrospectively employed sparse linear discriminant analysis (LDA), two existing electrodiagnostic criteria sets (Hadden et al., 1998; Rajabally et al., 2015) and one we propose that additionally evaluates duration of motor responses, sural sparing pattern and defines reversible conduction failure (RCF) in motor and sensory nerves at second study...
April 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28515218/group-b-streptococcus-among-pregnant-women-and-newborns-in-mirzapur-bangladesh-colonization-vertical-transmission-and-serotype-distribution
#7
Samir K Saha, Zabed B Ahmed, Joyanta K Modak, Hakka Naziat, Shampa Saha, Mohammad A Uddin, Maksuda Islam, Abdullah H Baqui, Gary L Darmstadt, Stephanie J Schrag
Group B Streptococcus (GBS) infection is a leading cause of death in newborns in developed countries. Data on burden of GBS in Asian countries is lacking. This study aimed to understand i) rate of maternal recto-vaginal GBS carriage, ii) vertical transmission of GBS as determined by culturing ear, umbilicus and nasal swabs, and iii) distribution of GBS serotypes. This prospective observational study was conducted from September 2012 to November 2013 at Kumudini Hospital, a secondary level hospital, at Mirzapur, Bangladesh...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28514704/guillain-barr%C3%A3-syndrome-variants-forms-fruste-reclassification-with-new-criteria
#8
Fu Liong Hiew, Rahmansah Ramlan, Shanthi Viswanathan, Santhi Puvanarajah
OBJECTIVES: This study aimed to evaluate the clinical and electrophysiological characteristics of various distinctive classical and localised Guillain-Barré syndrome (GBS) subtypes. PATIENTS AND METHODS: Clinical characteristics and electrophysiological data of sixty-one consecutive patients admitted between 2012 and 2015 were systematically analysed and reclassified according to the new GBS clinical classification. Neurophysiology was evaluated with Hadden et al...
May 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28508419/case-control-study-shows-that-neonatal-pneumococcal-meningitis-cannot-be-distinguished-from-group-b-streptococcus-cases
#9
Alexandra Arfi, Robert Cohen, Emmanuelle Varon, Stéphane Béchet, Stéphane Bonacorsi, Corinne Levy
AIM: Streptococcus pneumoniae (S. pneumoniae) is sometimes implicated in neonatal bacterial meningitis. This study described the demographic, clinical and biological features of neonatal S. pneumoniae meningitis and compared pneumococcal and group B streptococcal (GBS) neonatal meningitis. METHODS: We conducted a case-control study that compared neonates, aged one to 28 days with S. pneumoniae meningitis or GBS meningitis. Each case with S. pneumoniae was randomly matched to four control patients with GBS by age group and study year...
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28507676/formation-mechanism-of-overlapping-grain-boundaries-in-graphene-chemical-vapor-deposition-growth
#10
Jichen Dong, Huan Wang, Hailin Peng, Zhongfan Liu, Kaili Zhang, Feng Ding
The formation of grain boundaries (GBs) in graphene films is both fundamentally interesting and practically important for many applications. A GB in graphene is known as a linear defect and is formed during the coalescence of two single crystalline graphene domains. The covalent binding between domains is broadly known as the mechanism of GB formation during graphene chemical vapor deposition (CVD) growth. Here, we demonstrate another GB formation mechanism, where two graphene domains are connected by weak van der Waals interactions between overlapping graphene layers...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28507291/construction-of-genotyping-by-sequencing-based-high-density-genetic-maps-and-qtl-mapping-for-fusarium-wilt-resistance-in-pigeonpea
#11
Rachit K Saxena, Vikas K Singh, Sandip M Kale, Revathi Tathineni, Swathi Parupalli, Vinay Kumar, Vanika Garg, Roma R Das, Mamta Sharma, K N Yamini, S Muniswamy, Anuradha Ghanta, Abhishek Rathore, C V Sameer Kumar, K B Saxena, P B Kavi Kishor, Rajeev K Varshney
Fusarium wilt (FW) is one of the most important biotic stresses causing yield losses in pigeonpea. Genetic improvement of pigeonpea through genomics-assisted breeding (GAB) is an economically feasible option for the development of high yielding FW resistant genotypes. In this context, two recombinant inbred lines (RILs) (ICPB 2049 × ICPL 99050 designated as PRIL_A and ICPL 20096 × ICPL 332 designated as PRIL_B) and one F2 (ICPL 85063 × ICPL 87119) populations were used for the development of high density genetic maps...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28504863/diagnostic-accuracy-of-polymerase-chain-reaction-for-intrapartum-detection-of-group-b-streptococcus-colonization
#12
Rikke Bek Helmig, Jan Berg Gertsen
Many pregnant women are treated with antibiotics during labor to prevent transmission of group B Streptococcus (GBS, Streptococcus agalactiae) to their baby during the passage of the birth canal, and thus reducing the risk of serious infection of the newborn. Methods for intrapartum testing for GBS has been introduced to select women for whom intrapartum antibiotic prophylaxis should be offered. For such an intrapartum test to be useful in clinical practice, it has to be specific as well as sensitive. The aim of the present study is to evaluate the accuracy of the polymerase chain reaction (PCR) assay compared to an optimized culture method for GBS MATERIAL AND METHODS: In the period from 12...
May 15, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28502941/the-sequential-ultrasonographic-electrophysiological-and-mri-findings-in-a-patient-with-the-pharyngeal-cervical-brachial-variant-of-guillain-barr%C3%A3-syndrome-from-the-acute-phase-to-the-chronic-phase
#13
Tetsuya Miyagi, Katsuyuki Higa, Miwako Kido, Satoshi Ishihara, Ryo Nakachi, Syugo Suwazono
Acute progressive weakness in bulbar, neck and limbs is included in several differential diagnoses, including the pharyngeal-cervical-brachial (PCB) variant of Guillain-Barré syndrome (GBS). Patients with the PCB variant of GBS are reported to have localized diagnostic cervical spinal nerve abnormalities that can be examined by nerve ultrasonography (NUS) and magnetic resonance neurography (MRN). We herein report the case of a 77-year-old man with the PCB variant of GBS. Although the nerve conduction study (NCS) findings were indirect indicators for an early diagnosis, the combination of NCS and NUS was a useful complementary measure that facilitated an early diagnosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28500772/a-test-of-genomic-modularity-among-life-history-adaptations-promoting-speciation-with-gene-flow
#14
Gregory J Ragland, Meredith M Doellman, Peter Meyers, Glen R Hood, Scott P Egan, Thomas H Q Powell, Daniel A Hahn, Patrik Nosil, Jeffrey L Feder
Speciation-with-gene-flow may require adaptive divergence of multiple traits to generate strong ecologically based reproductive isolation. Extensive negative pleiotropy or physical linkage of genes in the wrong phase affecting these diverging traits may therefore hinder speciation, while genetic independence or 'modularity' among phenotypic traits may reduce constraints and facilitate divergence. Here, we test whether the genetics underlying two components of diapause life history, initial diapause intensity and diapause termination timing, constrain differentiation between sympatric hawthorn and apple-infesting host races of the fly Rhagoletis pomonella through analysis of 10,256 SNPs measured via Genotyping-By-Sequencing (GBS)...
May 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28500225/zika-virus-infection-associated-acute-transient-polyneuritis
#15
Osvaldo J M Nascimento, Jennifer A Frontera, Daniel A Amitrano, Ana M Bispo de Filippis, Ivan R F Da Silva
No abstract text is available yet for this article.
May 12, 2017: Neurology
https://www.readbyqxmd.com/read/28497819/disorder-induced-transition-from-grain-boundary-to-bulk-dominated-ionic-diffusion-in-pyrochlores
#16
Romain Perriot, Pratik P Dholabhai, Blas P Uberuaga
We use molecular dynamics simulations to investigate the role of grain boundaries (GBs) on ionic diffusion in pyrochlores, as a function of the GB type, chemistry of the compound, and level of cation disorder. We observe that the presence of GBs promotes oxygen transport in ordered and low-disordered systems, as the GBs are found to have a higher concentration of mobile carriers with higher mobilities than in the bulk. Thus, in ordered samples, the ionic diffusion is 2D, localized along the grain boundary. When cation disorder is introduced, bulk carriers begin to contribute to the overall diffusion, while the GB contribution is only slightly enhanced...
May 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28491217/-guillain-barr%C3%A3-syndrome-and-diabetic-acido-ketotic-decompensation-during-pregnancy-a-case-report-and-review-of-the-literature
#17
Lilia Affes, Mouna Elleuch, Fatma Mnif, Faten Hadj Kacem, Dhouha Ben Salah, Mouna Mnif, Nadia Charfi, Nabila Rekik, Mohamed Abid
A 27-year-old pregnant woman was admitted to the resuscitation department with severe spontaneous acute ketoacidosis as early symptom of type 1 diabetes. The patient underwent resuscitation and insulin treatment with good clinical and biological evolution. On day 4, the patient had polyradiculoneuritis characterised by acute onset. Additional emergency examinations were negative. Lumbar cytopunction showed albuminocytologic dissociation. Electromyogram confirmed the diagnosis of Guillain Barré syndrome (GBS)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28488614/safety-and-efficacy-of-therapeutic-membrane-plasmapheresis-in-the-treatment-of-guillain-barr%C3%A3-syndrome-a-study-from-a-tertiary-care-hospital-from-india
#18
Sanjay Vikrant, Surinder Thakur, Ashok Sharma, Dalip Gupta, Sudhir Sharma
BACKGROUND: Reports on therapeutic plasma exchange (TPE) with the standard hemodialysis equipment are scarce, particularly from developing countries. MATERIALS AND METHODS: A retrospective analysis of safety and efficacy of membrane-based TPE with a standard hemodialysis equipment for the treatment of severe Guillain-Barré syndrome (GBS) was conducted. RESULTS: A total of 120 TPE sessions were performed in 31 GBS patients over a period of 5½ years...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28487747/a-predictive-model-for-guillain-barr%C3%A3-syndrome-based-on-single-learning-algorithms
#19
Juana Canul-Reich, Juan Frausto-Solís, José Hernández-Torruco
Background. Guillain-Barré Syndrome (GBS) is a potentially fatal autoimmune neurological disorder. The severity varies among the four main subtypes, named as Acute Inflammatory Demyelinating Polyneuropathy (AIDP), Acute Motor Axonal Neuropathy (AMAN), Acute Motor Sensory Axonal Neuropathy (AMSAN), and Miller-Fisher Syndrome (MF). A proper subtype identification may help to promptly carry out adequate treatment in patients. Method. We perform experiments with 15 single classifiers in two scenarios: four subtypes' classification and One versus All (OvA) classification...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28487166/rapid-detection-of-group-b-streptococcus-directly-from-vaginal-rectal-specimens-using-liquid-swabs-and-the-bd-max-gbs-assay
#20
Justin A Ellem, Daniel Kovacevic, Tom Olma, Sharon C-A Chen
OBJECTIVE: We adapted the BD Max GBS assay, an automated platform for detection of Group B Streptococcus DNA in vaginal-rectal swab specimens after LIM broth enrichment, to directly detect GBS in specimens collected using cellular foam swabs in Amies liquid medium. We compared the BD Max GBS assay performance to that of enriched culture and the BD GeneOhm StrepB assay. METHODS: Seventy-two reference vaginal-rectal specimens were employed to determine the limit of GBS detection and the preferred test volume for direct detection of GBS...
May 6, 2017: Clinical Microbiology and Infection
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