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DNA silver nanocluster

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https://www.readbyqxmd.com/read/29328343/in-situ-fluorescence-activation-of-dna-silver-nanoclusters-as-a-label-free-and-general-strategy-for-cell-nucleus-imaging
#1
Duo Li, Zhenzhen Qiao, Yanru Yu, Jinlu Tang, Xiaoxiao He, Hui Shi, Xiaosheng Ye, Yanli Lei, Kemin Wang
A facile, general and turn-on nucleus imaging strategy was first developed based on in situ fluorescence activation of C-rich dark silver nanoclusters by G-rich telomeres. After a simple incubation without washing, nanoclusters could selectively stain the nucleus with intense red luminescence, which was confirmed using fixed/living cells and several cell lines.
January 12, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29306029/proximity-ligation-detection-of-lectin-concanavalin-a-and-fluorescence-imaging-cancer-cells-using-carbohydrate-functionalized-dna-silver-nanocluster-probes
#2
Xiaoru Zhang, Fengting Chen, Xiaojie Song, Peng He, Shusheng Zhang
A novel method for study the interaction between carbohydrate and lectin was developed in homogenous solution. DNA was introduced to the recognition process of carbohydrate with protein. Due to the versatile detection mode of DNA, the detection efficiency for carbohydrate and protein was highly promoted. Herein, two kinds of mannose-DNA conjugates were synthesized. One of which was used to prepare DNA-templated silver nanocluster (AgNCs) and the other one contained guanine-rich DNA sequences. When the mannose of two conjugates binding to lectin Concanavalin A (Con A), great enhancement on fluorescence intensity was obtained due to the proximity ligation of the DNA-templated Ag NCs with guanine-rich DNA sequences...
December 31, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29280301/a-fluorescent-biofunctional-dna-hydrogel-prepared-by-enzymatic-polymerization
#3
Jinhui Geng, Chi Yao, Xiaohong Kou, Jianpu Tang, Dan Luo, Dayong Yang
DNA has arisen as a promising building material for the construction of hydrogels owing to its unique properties such as designability and biocompatibility. All-DNA hydrogels with only DNA molecules may have limited applications; hence a composite DNA hydrogel with multifunctional moieties is highly desired to cater for specific applications. Herein, a multifunctional DNA hydrogel is created by incorporating DNA with silver nanoclusters (AgNCs), in which AgNCs render the hydrogel simultaneously with fluorescent and antibacterial functions...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29210418/thiolated-dna-templated-silver-nanoclusters-with-strong-fluorescence-emission-and-a-long-shelf-life
#4
Xiaohong Zhang, Yunxia Qian, Xuejuan Ma, Mengfan Xia, Shuangqin Li, Yaodong Zhang
Thiolated DNA (DNA-SH) was employed as a template in the synthesis and stabilization of AgNCs (DNA-SH-AgNCs). Resulting from the synergistic protective effect of specific Ag+-DNA interactions and Ag-S bonding, DNA-SH-AgNCs exhibited high quantum yields and resistance to oxidation.
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29199749/non-invasive-detection-of-gastric-cancer-relevant-d-amino-acids-with-luminescent-dna-silver-nanoclusters
#5
Zhikun Zhang, Yang Liu, Peifeng Liu, Lu Yang, Xingyu Jiang, Dan Luo, Dayong Yang
Chirality plays essential roles in life systems such that l-amino acids (LAAs) are predominantly found as the building units of protein for organisms. The presence of the d-enantiomer (DAA) has been found to be specifically relevant to gastric cancer. We herein construct a luminescent DNA/silver nanocluster based biosensing system to achieve rapid and specific detection of DAAs. As a proof of application, we detected DAAs in saliva samples from patients with gastric cancer, and the test results exhibited excellent specificity...
December 4, 2017: Nanoscale
https://www.readbyqxmd.com/read/29186575/dna-as-uv-light-harvesting-antenna
#6
Ivan L Volkov, Zakhar V Reveguk, Pavel Yu Serdobintsev, Ruslan R Ramazanov, Alexei I Kononov
The ordered structure of UV chromophores in DNA resembles photosynthetic light-harvesting complexes in which quantum coherence effects play a major role in highly efficient directional energy transfer. The possible role of coherent excitons in energy transport in DNA remains debated. Meanwhile, energy transport properties are greatly important for understanding the mechanisms of photochemical reactions in cellular DNA and for DNA-based artificial nanostructures. Here, we studied energy transfer in DNA complexes formed with silver nanoclusters and with intercalating dye (acridine orange)...
November 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29114653/temperature-dependent-excited-state-relaxation-of-a-red-emitting-dna-templated-silver-nanocluster
#7
Cecilia Cerretani, Miguel R Carro-Temboury, Stefan Krause, Sidsel Ammitzbøll Bogh, Tom Vosch
The nanosecond excited state temporal and spectral relaxation of a purified, red-emitting DNA-templated silver nanocluster (DNA-AgNC) was characterized as a function of temperature. The findings are explained by introducing a phenomenological electronic structure diagram. The reproducibility and cyclability of the average decay time opens up the possibility of using DNA-AgNCs for decay time-based nanothermometry.
November 8, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29032453/rapid-and-sensitive-detection-of-ketamine-in-blood-using-novel-fluorescence-genosensor
#8
Yanjun Ding, Xingmei Li, Yadong Guo, Jie Yan, Jiang Ling, Weichen Li, Lingmei Lan, Yunfeng Chang, Jifeng Cai, Lagabaiyla Zha
In recent years, drug abuse has been considered as a most challenging social problem that aroused public attention. Ketamine has increased in unregulated use as a 'recreational drug' in teenagers. However, there is no suitable and maneuverable detection method for ketamine in situ at the moment. Fluorescence sensor technique, with predominant recognition and simple operation, is a good potential application in drug detection. Here, we first reported a highly sensitive and selective fluorescence genosensor for rapid detection of ketamine based on DNA-templated silver nanoclusters (DNA-AgNCs) probes, in which the DNA sequence could specially recognize ketamine with high affinity...
October 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28858858/detection-of-large-deletion-in-human-brca1-gene-in-human-breast-carcinoma-mcf-7-cells-by-using-dna-silver-nanoclusters
#9
Yasaman Sadat Borghei, Morteza Hosseini, Mohammad Reza Ganjali
Here we describe a label-free detection strategy for large deletion mutation in breast cancer related gene BRCA1 based on a DNA-silver Nanocluster Fluorescence upon Recognition-Induced Hybridization. The specific hybridization of DNA templated silver nanoclusters fluorescent probe to target DNAs can act as effective templates for enhancement of AgNCs Fluorescence, which can be used to distinguish the deletion of BRCA1 due to different fluorescent intensities. Under the optimal conditions, the fluorescent intensity of the DNA-AgNCs increased with the increasing deletion type within a dynamic range from 1...
August 31, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28852006/a-rapid-evaluation-of-acute-hydrogen-sulfide-poisoning-in-blood-based-on-dna-cu-ag-nanocluster-fluorescence-probe
#10
Yanjun Ding, Xingmei Li, Ceng Chen, Jiang Ling, Weichen Li, Yadong Guo, Jie Yan, Lagabaiyla Zha, Jifeng Cai
Hydrogen sulfide (H2S) is a highly toxic gas as a cause of inhalational death. Accurate detection of H2S poisoning concentration is valuable and vital for forensic workers to estimate the cause of death. But so far, it is no uniform and reliable standard method to measure sulfide concentrations in H2S poisoning blood for forensic identification. This study introduces a fluorescence sensing technique into forensic research, in which a DNA-templated copper/silver nanocluster (DNA-Cu/AgNCs) fluorescence probe has been proposed to selective detection of S(2-)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842019/a-label-free-sensitive-method-for-membrane-protein-detection-based-on-aptamer-and-agncs-transfer
#11
Zhenjun Liu, Wansong Chen, Yajin Han, Jiang Ouyang, Min Chen, Shengqiang Hu, Liu Deng, You-Nian Liu
Recently, membrane proteins have been considered as candidate cancer biomarkers and drug targets, due to their important roles in numerous physiological processes. Therefore, a facile, sensitive and quantitative detection of the membrane proteins is crucial for better understanding their roles in cancer cells and further validating their function in clinical research. We report a highly facile and sensitive detection method for membrane proteins on living cells in situ based on membrane protein-triggered release of cytosine (C)-rich single-stranded DNA (ssDNA) sequences, and the subsequent silver nanoclusters (AgNCs) transfer from polymer to C-rich ssDNA...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28800705/two-photon-imaging-of-3d-organization-of-bimetallic-auag-nanoclusters-in-dna-matrix
#12
Katarzyna Brach, Magdalena Waszkielewicz, Joanna Olesiak-Banska, Marek Samoc, Katarzyna Matczyszyn
We report on two-photon excitation properties of small silver-doped gold nanoclusters (AuAgNCs) and on their three-dimensional arrangement in a hybrid system composed of DNA liquid crystals (LCs) and AuAgNCs. UV-vis and fluorescence spectroscopy, transmission electron microscopy (TEM), and multiphoton excitation spectroscopy were used to characterize the nanoparticles. We show that AuAgNCs exhibit two-photon excited luminescence (2PL) emission and second-harmonic generation (SHG) and that these properties remain the same in liquid crystalline matrix...
August 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28709087/novel-electrochemiluminescence-of-silver-nanoclusters-fabricated-on-triplex-dna-scaffolds-for-label-free-detection-of-biothiols
#13
Lingyan Feng, Li Wu, Feifei Xing, Lianzhe Hu, Jinsong Ren, Xiaogang Qu
Electrochemiluminescence (ECL) of metal nanoclusters and their application have been widely reported due to the good biocompatibility, fascinating electrocatalytic activity and so on. Using DNA as synthesis template opens new opportunities to modulate the physical properties of AgNCs. Triplex DNA has been reported for the site-specific, homogeneous and highly stable silver nanoclusters (AgNCs) fabrication from our recent research. Here we further explore their extraordinary ECL properties and applications in biosensor utilization...
July 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28662471/in-situ-grown-dna-nanotail-templated-silver-nanoclusters-enabling-label-free-electrochemical-sensing-of-terminal-deoxynucleotidyl-transferase-activity
#14
Yufang Hu, Qingqing Zhang, Zhiyong Guo, Sui Wang, Chunnuan Du, Chunyang Zhai
A novel label-free electrochemical strategy was established based on the unique electro-catalytic activity of graphene oxide (GO)-supported terminal deoxynucleotidyl transferase (TdT)-generated C-rich DNA nanotail-templated silver nanoclusters (DNA-AgNCs). TdT can catalyze the deoxycytidine triphosphate (dCTP) to the 3'-OH terminus of single-stranded DNA (ssDNA) with no template; then, in the presence of Ag(I), TdT-generated C-rich DNA sequence was employed for the synthetic template of AgNCs because of the formed complexes of nitrogen atoms of cytosine based with silver atoms...
June 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28646761/regulation-on-the-aggregation-induced-emission-aie-of-dna-templated-silver-nanoclusters-by-bsa-and-its-hydrolysates
#15
Wei-Xian Wang, Yuqing Wu, Hong-Wei Li
The aggregation-induced emission (AIE) phenomenon of the metal nanoclusters (NCs) has been discovered quite recently, which is considered to be creative to improve the optical properties of NCs upon ligand aggregation. In the present study, we report an AIE system for double-stranded DNA-templated silver nanoclusters (AgNCs-dsDNA) by using bovine serum albumin (BSA) in solution, which induce a moderate emission enhancement of AgNCs (5-fold) and a blue-shift through a loosen interaction. In addition, significant luminescence enhancement (30-fold) is further stimulated by the addition of digestive enzyme to the system by altering the surface structure of the aggregated particles...
November 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28626564/integration-of-g-quadruplex-and-dna-templated-ag-ncs-for-nonarithmetic-information-processing
#16
Ru-Ru Gao, Tian-Ming Yao, Xiao-Yan Lv, Yan-Yan Zhu, Yi-Wei Zhang, Shuo Shi
To create sophisticated molecular logic circuits from scratch, you may not believe how common the building blocks can be and how diverse and powerful such circuits can be when scaled up. Using the two simple building blocks of G-quadruplex and silver nanoclusters (Ag NCs), we experimentally construct a series of multifunctional, label-free, and multi-output logic circuits to perform nonarithmetic functions: a 1-to-2 decoder, a 4-to-2 encoder, an 8-to-3 encoder, dual transfer gates, a 2 : 1 multiplexer, and a 1 : 2 demultiplexer...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28548085/ultrafast-coherence-transfer-in-dna-templated-silver-nanoclusters
#17
Erling Thyrhaug, Sidsel Ammitzbøll Bogh, Miguel R Carro-Temboury, Charlotte Stahl Madsen, Tom Vosch, Donatas Zigmantas
DNA-templated silver nanoclusters of a few tens of atoms or less have come into prominence over the last several years due to very strong absorption and efficient emission. Applications in microscopy and sensing have already been realized, however little is known about the excited-state structure and dynamics in these clusters. Here we report on a multidimensional spectroscopy investigation of the energy-level structure and the early-time relaxation cascade, which eventually results in the population of an emitting state...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28510342/constructing-a-robust-fluorescent-dna-stabilized-silver-nanocluster-probe-module-by-attaching-a-duplex-moiety
#18
Ruoyun Lin, Guangyu Tao, Yang Chen, Mingxing Chen, Feng Liu, Na Li
Fluorescent DNA-templated silver nanoclusters (DNA-Ag NCs) have served as excellent luminescent probes and operation units in various applications. However, the fluorescence property of DNA-Ag NCs is very sensitive to elongation or modification of the DNA template, limiting the breadth of applications. In this work, we propose a strategy for constructing a robust fluorescent DNA-Ag NCs probe module by attaching a duplex moiety to the nanocluster-bearing sequence. The fluorescence intensity of the DNA-Ag NCs can be enhanced 90-fold upon hybridization of the elongated moiety...
May 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28500353/estimation-of-postmortem-interval-by-vitreous-potassium-evaluation-with-a-novel-fluorescence-aptasensor
#19
Yanjun Ding, Xingmei Li, Yadong Guo, Weicheng Duan, Jiang Ling, Lagabaiyla Zha, Jie Yan, Ying Zou, Jifeng Cai
Estimation of postmortem interval (PMI) is a central role in medico-legal identification. Analysis of vitreous potassium ions (K(+)) concentration is frequently used by forensic workers to estimate PMI. This paper describes interdisciplinary research to introduce fluorescence sensing techniques into forensic medicine. On the basis of silver nanoclusters (AgNCs) probe stabilized by DNA, a simple and highly sensitive fluorescence aptasensor has been proposed to selectively detect K(+) ions. The linear range for K(+) ions was found to be 0...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28460331/a-novel-fluorometric-and-colorimetric-sensor-for-iodide-determination-using-dna-templated-gold-silver-nanoclusters
#20
Zihao Li, Ruiyi Liu, Guofeng Xing, Tong Wang, Siyu Liu
Determination of iodide ions has attracted considerable interest due to the importance and urgency. In the current work, we have developed a novel fluorescent and colorimetric platform for simple and selective detection of iodide ions based on the DNA-templated gold/silver nanoclusters (DNA-Au/Ag NCs). The detection system is based on the unique interaction between iodide ions and DNA-Au/Ag NCs, which shows an obvious fluorescence quenching with the addition of iodide ions and a good linear range from 0 to 10μmol/L for iodide ions...
January 4, 2017: Biosensors & Bioelectronics
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