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https://www.readbyqxmd.com/read/28216110/the-current-global-state-of-key-lifestyle-characteristics-health-and-economic-implications
#1
REVIEW
Ross Arena, Amy McNeil, Michael Sagner, Andrew P Hills
The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals, families and communities, placing an unsustainable burden on health systems. There is hope for the chronic disease crisis in that these conditions are largely preventable or can be delayed to much later in life through a timeless medicine, healthy living...
February 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28208842/assessment-of-serum-vaspin-levels-among-type-2-diabetes-mellitus-patients-with-or-without-acute-coronary-syndrome
#2
Aswathy Jaya Sathyaseelan, Prashant Shankarrao Adole, Mukta Wyawahare, Rama Prakasha Saya
INTRODUCTION: Type 2 Diabetes Mellitus (DM) is on the verge of becoming a pandemic in India. Type 2 DM patient have two to four times increased risk of carotid artery disease. Adipokines have been regarded recently as direct link between diabetes and atherosclerosis. Visceral Adipose Tissue Derived Serine Protease Inhibitor (VASPIN); one of the most recently discovered adipokine, inhibits the proteases responsible for insulin resistance, carotid plaque development and rupture. In literature, few studies have addressed the role of VASPIN in pathogenesis of Acute Coronary Syndrome (ACS) in patients with type 2 DM...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28143481/serum-levels-of-interleukin-22-cardiometabolic-risk-factors-and-incident-type-2-diabetes-kora-f4-ff4-study
#3
Christian Herder, Julia M Kannenberg, Maren Carstensen-Kirberg, Cornelia Huth, Christa Meisinger, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann, Michael Roden, Barbara Thorand
AIMS: Interleukin-22 (IL-22) has beneficial effects on body weight, insulin resistance and inflammation in different mouse models, but its relevance for the development of type 2 diabetes in humans is unknown. We aimed to identify correlates of serum IL-22 levels and to test the hypothesis that higher IL-22 levels are associated with lower diabetes incidence. METHODS: Cross-sectional associations between serum IL-22, cardiometabolic risk factors and glucose tolerance status were investigated in 1107 persons of the population-based KORA F4 study...
January 31, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28052647/the-modulative-effects-of-microcurrent-electrical-nerve-stimulation-on-diabetic-mice
#4
Wen-Ching Huang, Wen-Chieh Chang, Yi-Ju Hsu, Chun-Feng Huang, Chi-Chang Huang, Cheng-Yan Kao, Che-Li Lin
Diabetes (one of non-communicable diseases) is serious due to its complications, such like, cardiovascular ailments, neuropathy, nephropathy, retinopathy, wound gangrene and sexual impotence. Diabetes and associated chronic conditions are rapidly emerging as major health problems. In clinical, there were different drugs for diabetes treatment on different mechanisms. However, there were limited studies on the efficacy of electric stimulations on diabetes therapeutic application. In current study, we try to evaluate the effect of microcurrent electrical nerve stimulator (MENS) on diabetes modulation as an alternative medicine...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/27940180/the-lifestyle-intervention-for-the-treatment-of-diabetes-study-lift-diabetes-design-and-baseline-characteristics-for-a-randomized-translational-trial-to-improve-control-of-cardiovascular-disease-risk-factors
#5
Jeffrey A Katula, Julienne K Kirk, Carolyn F Pedley, Margaret R Savoca, Valery S Effoe, Ronny A Bell, Alain G Bertoni
The prevalence of type 2 diabetes continues to increase in minority and underserved patients, who are also more likely to have poorer control of diabetes and related risk factors for complications. Although the Look AHEAD trial has demonstrated improved risk factor control among overweight or obese diabetes patients who received an intensive lifestyle intervention, translating such findings into accessible programs is a major public health challenge. The purpose of this paper is to report the design and baseline characteristics of the Lifestyle Interventions for the Treatment of Diabetes study (LIFT Diabetes)...
February 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27913572/very-low-density-lipoprotein-vldl-induced-signals-mediating-aldosterone-production
#6
REVIEW
Ying-Ying Tsai, William E Rainey, Wendy B Bollag
Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus increasing blood volume and pressure. Excessive production of aldosterone results in high blood pressure and contributes to cardiovascular and renal disease, stroke and visual loss. Hypertension is also associated with obesity, which is correlated with other serious health risks as well. Although weight gain is associated with increased blood pressure, the mechanism by which excess fat deposits increase blood pressure remains unclear...
February 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27876066/in-vivo-cardiovascular-magnetic-resonance-of-2d-vessel-wall-diffusion-anisotropy-in-carotid-arteries
#7
Peter Opriessnig, Harald Mangge, Rudolf Stollberger, Hannes Deutschmann, Gernot Reishofer
BACKGROUND: Diffusion weighted (DW) cardiovascular magnetic resonance (CMR) has shown great potential to discriminate between healthy and diseased vessel tissue by evaluating the apparent diffusion coefficient (ADC) along the arterial axis. Recently, ex vivo studies on porcine arteries utilizing diffusion tensor imaging (DTI) revealed a circumferential fiber orientation rather than an organization in axial direction, suggesting dominant diffusion perpendicular to the slice direction. In the present study, we propose a method to access tangential and radial diffusion of carotids in vivo by utilizing a pulse sequence that enables high resolution DW imaging in combination with a two-dimensional (2D) diffusion gradient direction sampling scheme perpendicular to the longitudinal axis of the artery...
November 23, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27874050/automatic-identification-of-systolic-time-intervals-in-seismocardiogram
#8
Ghufran Shafiq, Sivanagaraja Tatinati, Wei Tech Ang, Kalyana C Veluvolu
Continuous and non-invasive monitoring of hemodynamic parameters through unobtrusive wearable sensors can potentially aid in early detection of cardiac abnormalities, and provides a viable solution for long-term follow-up of patients with chronic cardiovascular diseases without disrupting the daily life activities. Electrocardiogram (ECG) and siesmocardiogram (SCG) signals can be readily acquired from light-weight electrodes and accelerometers respectively, which can be employed to derive systolic time intervals (STI)...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27753942/os-06-07-combining-short-and-long-term-risk-scores-in-primary-prevention-of-major-cardiovascular-disease-events-in-low-incidence-populations-an-assessment-of-clinical-utility
#9
Giovanni Veronesi, Simona Giampaoli, Francesco Gianfagna, Luigi Palmieri, Diego Vanuzzo, Guido Grassi, Giancarlo Cesana, Marco M Ferrario
OBJECTIVE: To evaluate the clinical utility of the CAMUNI-MATISS 20-year risk score, recently validated for the Italian population, as additional screening tool for individuals at "low" (ESC-SCORE Project predicted 10-year risk ≤ 1%; no preventive action), "intermediate" (ESC-SCORE 1-4%; lifestyle modification/statin treatment) and "high" risk (ESC-SCORE≥ 4% or diabetes; statin treatment) according to the Italian regulation. DESIGN AND METHOD: 40-65 years old initially CVD-free participants to 7 population-based cohorts enrolled in Northern and Central Italy between 1986 and 1996 were followed-up (median 16 years, IQR: 12-20) to the first occurrence of coronary event or ischemic stroke (fatal or non-fatal), coronary or carotid revascularizations...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752272/predicting-metabolic-syndrome-using-decision-tree-and-support-vector-machine-methods
#10
Farzaneh Karimi-Alavijeh, Saeed Jalili, Masoumeh Sadeghi
BACKGROUND: Metabolic syndrome which underlies the increased prevalence of cardiovascular disease and Type 2 diabetes is considered as a group of metabolic abnormalities including central obesity, hypertriglyceridemia, glucose intolerance, hypertension, and dyslipidemia. Recently, artificial intelligence based health-care systems are highly regarded because of its success in diagnosis, prediction, and choice of treatment. This study employs machine learning technics for predict the metabolic syndrome...
May 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/27699144/identifying-metabolic-syndrome-in-a-clinical-cohort-implications-for-prevention-of-chronic-disease
#11
Allison Martin, Elizabeth P Neale, Marjka Batterham, Linda C Tapsell
In the clinical setting, calculating cardiovascular disease (CVD) risk is commonplace but the utility of the harmonised equation for metabolic syndrome (MetS) (Alberti et al., 2009) is less well established. The aims of this study were to apply this equation to an overweight clinical cohort to identify risk factors for being metabolically unhealthy and explore associations with chronic disease. Baseline data were analysed from a lifestyle intervention trial of Illawarra residents recruited in 2014/2015. Participants were aged 25-54 years with a BMI 25-40 kg/m(2)...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27649286/effectiveness-and-cost-effectiveness-of-interventions-that-cause-weight-loss-and-reduce-the-risk-of-cardiovascular-disease
#12
Ella Zomer, Rachel Leach, Christine Trimmer, Tim Lobstein, Stephen Morris, William P James, Nick Finer
BACKGROUND: Overweight/obesity is associated with significant morbidity, mortality and costs. Weight loss has been shown to reverse some of these effects, reducing the risk of chronic diseases such as cardiovascular disease (CVD). AIM: To determine the potential monies available, from an English National Health Service perspective, for weight loss interventions to be cost-effective in the prevention of CVD. METHODS: A Markov model was developed, populated with overweight/obese individuals from the Health Survey for England, aged 30-74 years, free of pre-existing CVD and with available risk factor information to calculate CVD risk...
January 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27643337/os-06-07-combining-short-and-long-term-risk-scores-in-primary-prevention-of-major-cardiovascular-disease-events-in-low-incidence-populations-an-assessment-of-clinical-utility
#13
Giovanni Veronesi, Simona Giampaoli, Francesco Gianfagna, Luigi Palmieri, Diego Vanuzzo, Guido Grassi, Giancarlo Cesana, Marco M Ferrario
OBJECTIVE: To evaluate the clinical utility of the CAMUNI-MATISS 20-year risk score, recently validated for the Italian population, as additional screening tool for individuals at "low" (ESC-SCORE Project predicted 10-year risk ≤ 1%; no preventive action), "intermediate" (ESC-SCORE 1-4%; lifestyle modification/statin treatment) and "high" risk (ESC-SCORE≥ 4% or diabetes; statin treatment) according to the Italian regulation. DESIGN AND METHOD: 40-65 years old initially CVD-free participants to 7 population-based cohorts enrolled in Northern and Central Italy between 1986 and 1996 were followed-up (median 16 years, IQR: 12-20) to the first occurrence of coronary event or ischemic stroke (fatal or non-fatal), coronary or carotid revascularizations...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27597812/an-analysis-of-patient-sharing-physician-networks-and-implantable-cardioverter-defibrillator-therapy
#14
Erika L Moen, Andrea M Austin, Julie P Bynum, Jonathan S Skinner, A James O'Malley
The application of social network analysis to the organization of healthcare delivery is a relatively new area of research that may not be familiar to health services statisticians and other methodologists. We present a methodological introduction to social network analysis with a case study of physicians' adherence to clinical guidelines regarding use of implantable cardioverter defibrillators (ICDs) for the prevention of sudden cardiac death. We focus on two hospital referral regions (HRRs) in Indiana, Gary and South Bend, characterized by different rates of evidence-based ICD use (86% and 66%, respectively)...
September 2016: Health Services & Outcomes Research Methodology
https://www.readbyqxmd.com/read/27590905/combined-statin-and-angiotensin-converting-enzyme-ace-inhibitor-treatment-increases-the-lifespan-of-long-lived-f1-male-mice
#15
Stephen R Spindler, Patricia L Mote, James M Flegal
Statins, such as simvastatin, and ACE inhibitors (ACEis), such as ramipril, are standard therapies for the prevention and treatment of cardiovascular diseases. These types of drugs are commonly administered together. More recently, angiotensin II type 1 receptor (AT1R) antagonists, such as candesartan cilexetil (candesartan), have been used in the place of, or in combination with, ACEis. Here, we investigated the effects of simvastatin and ramipril single and combination therapy, and candesartan treatment on the lifespan of isocalorically fed, long-lived, B6C3F1 mice...
December 2016: Age (2005-)
https://www.readbyqxmd.com/read/27585884/poor-maternal-nutrition-and-accelerated-postnatal-growth-induces-an-accelerated-aging-phenotype-and-oxidative-stress-in-skeletal-muscle-of-male-rats
#16
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Jian Hua Chen, Iain P Hargreaves, Viruna Neergheen, Catherine E Aiken, Susan E Ozanne
'Developmental programming', which occurs as a consequence of suboptimal in utero and early environments, can be associated with metabolic dysfunction in later life, including an increased incidence of cardiovascular disease and type 2 diabetes, and predisposition of older men to sarcopenia. However, the molecular mechanisms underpinning these associations are poorly understood. Many conditions associated with developmental programming are also known to be associated with the aging process. We therefore utilized our well-established rat model of low birth weight and accelerated postnatal catch-up growth (termed 'recuperated') in this study to establish the effects of suboptimal maternal nutrition on age-associated factors in skeletal muscle...
October 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27505443/prevalence-and-factors-associated-with-statin-use-among-a-nationally-representative-sample-of-us-adults-national-health-and-nutrition-examination-survey-2011-2012
#17
Demilade Adedinsewo, Nchang Taka, Pradyumna Agasthi, Rajesh Sachdeva, George Rust, Anekwe Onwuanyi
The 2013 American College of Cardiology/American Heart Association guidelines recommend statins for adults age ≤75 years who have clinical atherosclerotic cardiovascular disease (IA) and adults age 40 to 75 years with diabetes mellitus and LDL-C 70-189 mg/dl (IA). Our aim was to estimate the prevalence and likelihood of statin use among selected statin benefit groups. Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2012, we examined 5319 adults age ≥20 years. We estimated weighted frequencies and prevalence of statin use for adults with diabetes mellitus and dyslipidemia (or low-density lipoprotein cholesterol ≥70 mg/dL), defined as statin benefit group 1 (SBG1); and for adults with atherosclerotic cardiovascular disease, defined as statin benefit group 2 (SBG2)...
September 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27464510/rationale-design-and-methods-for-canadian-alliance-for-healthy-hearts-and-minds-cohort-study-cahhm-a-pan-canadian-cohort-study
#18
Sonia S Anand, Jack V Tu, Philip Awadalla, Sandra Black, Catherine Boileau, David Busseuil, Dipika Desai, Jean-Pierre Després, Russell J de Souza, Trevor Dummer, Sébastien Jacquemont, Bartha Knoppers, Eric Larose, Scott A Lear, Francois Marcotte, Alan R Moody, Louise Parker, Paul Poirier, Paula J Robson, Eric E Smith, John J Spinelli, Jean-Claude Tardif, Koon K Teo, Natasa Tusevljak, Matthias G Friedrich
BACKGROUND: The Canadian Alliance for Healthy Hearts and Minds (CAHHM) is a pan-Canadian, prospective, multi-ethnic cohort study being conducted in Canada. The overarching objective of the CAHHM is to understand the association of socio-environmental and contextual factors (such as societal structure, activity, nutrition, social and tobacco environments, and access to health services) with cardiovascular risk factors, subclinical vascular disease, and cardiovascular and other chronic disease outcomes...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27459037/hypolipidemic-effects-of-myrica-rubra-extracts-and-main-compounds-in-c57bl-6j-mice
#19
Kai He, Xuegang Li, Yubo Xiao, Yang Yong, Zaiqi Zhang, Shuping Li, Taimei Zhou, Daqing Yang, Pincao Gao, Xiaoliang Xin
The present study evaluated the antihyperlipidemic activity of myricetin, myricetrin, the alcohol fraction (AF) and the ethyl acetate fraction (EF) obtained from the bark of Myrica rubra (MR) in high-fat and high-cholesterol (HFHC) induced hyperlipidemic C57BL/6j mice. Mice were treated with myricetin, myricetrin, AF and EF with a dose of 130 mg per kg per day for 35 days. After treatment, serum parameters including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), total bile acids (TBA), etc...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27421729/effects-of-exercise-training-alone-vs-a-combined-exercise-and-nutritional-lifestyle-intervention-on-glucose-homeostasis-in-prediabetic-individuals-a-randomised-controlled-trial
#20
Cris A Slentz, Lori A Bateman, Leslie H Willis, Esther O Granville, Lucy W Piner, Gregory P Samsa, Tracy L Setji, Michael J Muehlbauer, Kim M Huffman, Connie W Bales, William E Kraus
AIMS/HYPOTHESIS: Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the 'gold standard' preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the combined diet and exercise effect of DPP is unknown; furthermore, the optimal intensity of exercise for preventing progression to diabetes remains very controversial. To establish clinical efficacy, we undertook a study (2009 to 2013) to determine: how much of the effect on measures of glucose homeostasis of a 6 month programme modelled after the first 6 months of the DPP is due to exercise alone; whether moderate- or vigorous-intensity exercise is better for improving glucose homeostasis; and to what extent amount of exercise is a contributor to improving glucose control...
October 2016: Diabetologia
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