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https://www.readbyqxmd.com/read/27913572/very-low-density-lipoprotein-vldl-induced-signals-mediating-aldosterone-production
#1
Ying-Ying Tsai, William E Rainey, Wendy B Bollag
Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus increasing blood volume and pressure. Excessive production of aldosterone results in high blood pressure, and contributes to cardiovascular and renal disease, stroke, and visual loss. Hypertension is also associated with obesity, which s correlated with other serious health risks as well. Although weight gain is associated with increased blood pressure, the mechanism by which excess fat deposits increase blood pressure remains unclear...
December 2, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27876066/in-vivo-cardiovascular-magnetic-resonance-of-2d-vessel-wall-diffusion-anisotropy-in-carotid-arteries
#2
Peter Opriessnig, Harald Mangge, Rudolf Stollberger, Hannes Deutschmann, Gernot Reishofer
BACKGROUND: Diffusion weighted (DW) cardiovascular magnetic resonance (CMR) has shown great potential to discriminate between healthy and diseased vessel tissue by evaluating the apparent diffusion coefficient (ADC) along the arterial axis. Recently, ex vivo studies on porcine arteries utilizing diffusion tensor imaging (DTI) revealed a circumferential fiber orientation rather than an organization in axial direction, suggesting dominant diffusion perpendicular to the slice direction. In the present study, we propose a method to access tangential and radial diffusion of carotids in vivo by utilizing a pulse sequence that enables high resolution DW imaging in combination with a two-dimensional (2D) diffusion gradient direction sampling scheme perpendicular to the longitudinal axis of the artery...
November 23, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27874050/automatic-identification-of-systolic-time-intervals-in-seismocardiogram
#3
Ghufran Shafiq, Sivanagaraja Tatinati, Wei Tech Ang, Kalyana C Veluvolu
Continuous and non-invasive monitoring of hemodynamic parameters through unobtrusive wearable sensors can potentially aid in early detection of cardiac abnormalities, and provides a viable solution for long-term follow-up of patients with chronic cardiovascular diseases without disrupting the daily life activities. Electrocardiogram (ECG) and siesmocardiogram (SCG) signals can be readily acquired from light-weight electrodes and accelerometers respectively, which can be employed to derive systolic time intervals (STI)...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27753942/os-06-07-combining-short-and-long-term-risk-scores-in-primary-prevention-of-major-cardiovascular-disease-events-in-low-incidence-populations-an-assessment-of-clinical-utility
#4
Giovanni Veronesi, Simona Giampaoli, Francesco Gianfagna, Luigi Palmieri, Diego Vanuzzo, Guido Grassi, Giancarlo Cesana, Marco M Ferrario
OBJECTIVE: To evaluate the clinical utility of the CAMUNI-MATISS 20-year risk score, recently validated for the Italian population, as additional screening tool for individuals at "low" (ESC-SCORE Project predicted 10-year risk ≤ 1%; no preventive action), "intermediate" (ESC-SCORE 1-4%; lifestyle modification/statin treatment) and "high" risk (ESC-SCORE≥ 4% or diabetes; statin treatment) according to the Italian regulation. DESIGN AND METHOD: 40-65 years old initially CVD-free participants to 7 population-based cohorts enrolled in Northern and Central Italy between 1986 and 1996 were followed-up (median 16 years, IQR: 12-20) to the first occurrence of coronary event or ischemic stroke (fatal or non-fatal), coronary or carotid revascularizations...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752272/predicting-metabolic-syndrome-using-decision-tree-and-support-vector-machine-methods
#5
Farzaneh Karimi-Alavijeh, Saeed Jalili, Masoumeh Sadeghi
BACKGROUND: Metabolic syndrome which underlies the increased prevalence of cardiovascular disease and Type 2 diabetes is considered as a group of metabolic abnormalities including central obesity, hypertriglyceridemia, glucose intolerance, hypertension, and dyslipidemia. Recently, artificial intelligence based health-care systems are highly regarded because of its success in diagnosis, prediction, and choice of treatment. This study employs machine learning technics for predict the metabolic syndrome...
May 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/27699144/identifying-metabolic-syndrome-in-a-clinical-cohort-implications-for-prevention-of-chronic-disease
#6
Allison Martin, Elizabeth P Neale, Marjka Batterham, Linda C Tapsell
In the clinical setting, calculating cardiovascular disease (CVD) risk is commonplace but the utility of the harmonised equation for metabolic syndrome (MetS) (Alberti et al., 2009) is less well established. The aims of this study were to apply this equation to an overweight clinical cohort to identify risk factors for being metabolically unhealthy and explore associations with chronic disease. Baseline data were analysed from a lifestyle intervention trial of Illawarra residents recruited in 2014/2015. Participants were aged 25-54 years with a BMI 25-40 kg/m(2)...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27649286/effectiveness-and-cost-effectiveness-of-interventions-that-cause-weight-loss-and-reduce-the-risk-of-cardiovascular-disease
#7
Ella Zomer, Rachel Leach, Christine Trimmer, Tim Lobstein, Stephen Morris, William P James, Nick Finer
BACKGROUND: Overweight/obesity is associated with significant morbidity, mortality and costs. Weight loss has been shown to reverse some of these effects, reducing the risk of chronic diseases such as cardiovascular disease (CVD). AIM: To determine the potential monies available, from an English National Health Service perspective, for weight loss interventions to be cost-effective in the prevention of CVD. METHODS: A Markov model was developed, populated with overweight/obese individuals from the Health Survey for England, aged 30-74 years, free of pre-existing CVD and with available risk factor information to calculate CVD risk...
September 20, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27643337/os-06-07-combining-short-and-long-term-risk-scores-in-primary-prevention-of-major-cardiovascular-disease-events-in-low-incidence-populations-an-assessment-of-clinical-utility
#8
Giovanni Veronesi, Simona Giampaoli, Francesco Gianfagna, Luigi Palmieri, Diego Vanuzzo, Guido Grassi, Giancarlo Cesana, Marco M Ferrario
OBJECTIVE: To evaluate the clinical utility of the CAMUNI-MATISS 20-year risk score, recently validated for the Italian population, as additional screening tool for individuals at "low" (ESC-SCORE Project predicted 10-year risk ≤ 1%; no preventive action), "intermediate" (ESC-SCORE 1-4%; lifestyle modification/statin treatment) and "high" risk (ESC-SCORE≥ 4% or diabetes; statin treatment) according to the Italian regulation. DESIGN AND METHOD: 40-65 years old initially CVD-free participants to 7 population-based cohorts enrolled in Northern and Central Italy between 1986 and 1996 were followed-up (median 16 years, IQR: 12-20) to the first occurrence of coronary event or ischemic stroke (fatal or non-fatal), coronary or carotid revascularizations...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27597812/an-analysis-of-patient-sharing-physician-networks-and-implantable-cardioverter-defibrillator-therapy
#9
Erika L Moen, Andrea M Austin, Julie P Bynum, Jonathan S Skinner, A James O'Malley
The application of social network analysis to the organization of healthcare delivery is a relatively new area of research that may not be familiar to health services statisticians and other methodologists. We present a methodological introduction to social network analysis with a case study of physicians' adherence to clinical guidelines regarding use of implantable cardioverter defibrillators (ICDs) for the prevention of sudden cardiac death. We focus on two hospital referral regions (HRRs) in Indiana, Gary and South Bend, characterized by different rates of evidence-based ICD use (86% and 66%, respectively)...
September 2016: Health Services & Outcomes Research Methodology
https://www.readbyqxmd.com/read/27590905/combined-statin-and-angiotensin-converting-enzyme-ace-inhibitor-treatment-increases-the-lifespan-of-long-lived-f1-male-mice
#10
Stephen R Spindler, Patricia L Mote, James M Flegal
Statins, such as simvastatin, and ACE inhibitors (ACEis), such as ramipril, are standard therapies for the prevention and treatment of cardiovascular diseases. These types of drugs are commonly administered together. More recently, angiotensin II type 1 receptor (AT1R) antagonists, such as candesartan cilexetil (candesartan), have been used in the place of, or in combination with, ACEis. Here, we investigated the effects of simvastatin and ramipril single and combination therapy, and candesartan treatment on the lifespan of isocalorically fed, long-lived, B6C3F1 mice...
September 2, 2016: Age (2005-)
https://www.readbyqxmd.com/read/27585884/poor-maternal-nutrition-and-accelerated-postnatal-growth-induces-an-accelerated-aging-phenotype-and-oxidative-stress-in-skeletal-muscle-of-male-rats
#11
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Jian Hua Chen, Iain P Hargreaves, Viruna Neergheen, Catherine E Aiken, Susan E Ozanne
'Developmental programming', which occurs as a consequence of suboptimal in utero and early environments, can be associated with metabolic dysfunction in later life, including an increased incidence of cardiovascular disease and type 2 diabetes, and predisposition of older men to sarcopenia. However, the molecular mechanisms underpinning these associations are poorly understood. Many conditions associated with developmental programming are also known to be associated with the aging process. We therefore utilized our well-established rat model of low birth weight and accelerated postnatal catch-up growth (termed 'recuperated') in this study to establish the effects of suboptimal maternal nutrition on age-associated factors in skeletal muscle...
October 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27505443/prevalence-and-factors-associated-with-statin-use-among-a-nationally-representative-sample-of-us-adults-national-health-and-nutrition-examination-survey-2011-2012
#12
Demilade Adedinsewo, Nchang Taka, Pradyumna Agasthi, Rajesh Sachdeva, George Rust, Anekwe Onwuanyi
The 2013 American College of Cardiology/American Heart Association guidelines recommend statins for adults age ≤75 years who have clinical atherosclerotic cardiovascular disease (IA) and adults age 40 to 75 years with diabetes mellitus and LDL-C 70-189 mg/dl (IA). Our aim was to estimate the prevalence and likelihood of statin use among selected statin benefit groups. Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2012, we examined 5319 adults age ≥20 years. We estimated weighted frequencies and prevalence of statin use for adults with diabetes mellitus and dyslipidemia (or low-density lipoprotein cholesterol ≥70 mg/dL), defined as statin benefit group 1 (SBG1); and for adults with atherosclerotic cardiovascular disease, defined as statin benefit group 2 (SBG2)...
September 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27464510/rationale-design-and-methods-for-canadian-alliance-for-healthy-hearts-and-minds-cohort-study-cahhm-a-pan-canadian-cohort-study
#13
Sonia S Anand, Jack V Tu, Philip Awadalla, Sandra Black, Catherine Boileau, David Busseuil, Dipika Desai, Jean-Pierre Després, Russell J de Souza, Trevor Dummer, Sébastien Jacquemont, Bartha Knoppers, Eric Larose, Scott A Lear, Francois Marcotte, Alan R Moody, Louise Parker, Paul Poirier, Paula J Robson, Eric E Smith, John J Spinelli, Jean-Claude Tardif, Koon K Teo, Natasa Tusevljak, Matthias G Friedrich
BACKGROUND: The Canadian Alliance for Healthy Hearts and Minds (CAHHM) is a pan-Canadian, prospective, multi-ethnic cohort study being conducted in Canada. The overarching objective of the CAHHM is to understand the association of socio-environmental and contextual factors (such as societal structure, activity, nutrition, social and tobacco environments, and access to health services) with cardiovascular risk factors, subclinical vascular disease, and cardiovascular and other chronic disease outcomes...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27459037/hypolipidemic-effects-of-myrica-rubra-extracts-and-main-compounds-in-c57bl-6j-mice
#14
Kai He, Xuegang Li, Yubo Xiao, Yang Yong, Zaiqi Zhang, Shuping Li, Taimei Zhou, Daqing Yang, Pincao Gao, Xiaoliang Xin
The present study evaluated the antihyperlipidemic activity of myricetin, myricetrin, the alcohol fraction (AF) and the ethyl acetate fraction (EF) obtained from the bark of Myrica rubra (MR) in high-fat and high-cholesterol (HFHC) induced hyperlipidemic C57BL/6j mice. Mice were treated with myricetin, myricetrin, AF and EF with a dose of 130 mg per kg per day for 35 days. After treatment, serum parameters including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), total bile acids (TBA), etc...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27421729/effects-of-exercise-training-alone-vs-a-combined-exercise-and-nutritional-lifestyle-intervention-on-glucose-homeostasis-in-prediabetic-individuals-a-randomised-controlled-trial
#15
Cris A Slentz, Lori A Bateman, Leslie H Willis, Esther O Granville, Lucy W Piner, Gregory P Samsa, Tracy L Setji, Michael J Muehlbauer, Kim M Huffman, Connie W Bales, William E Kraus
AIMS/HYPOTHESIS: Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the 'gold standard' preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the combined diet and exercise effect of DPP is unknown; furthermore, the optimal intensity of exercise for preventing progression to diabetes remains very controversial. To establish clinical efficacy, we undertook a study (2009 to 2013) to determine: how much of the effect on measures of glucose homeostasis of a 6 month programme modelled after the first 6 months of the DPP is due to exercise alone; whether moderate- or vigorous-intensity exercise is better for improving glucose homeostasis; and to what extent amount of exercise is a contributor to improving glucose control...
October 2016: Diabetologia
https://www.readbyqxmd.com/read/27398222/correlation-of-adiposity-indices-with-cardiovascular-disease-risk-factors-in-healthy-adults-of-singapore-a-cross-sectional-study
#16
Xinyan Bi, Siew Ling Tey, Claudia Leong, Rina Quek, Yi Ting Loo, Christiani Jeyakumar Henry
BACKGROUND: Obesity has long been highlighted for its association with increased incidence of cardiovascular disease (CVD). Nonetheless, the best adiposity indices to evaluate the CVD risk factors remain contentious and few studies have been performed in Asian populations. In the present study, we compared the association strength of percent body fat (PBF) to indirect anthropometric measures of general adiposity (body mass index (BMI) and body adiposity index (BAI)) and central adiposity (waist circumference (WC), and waist-to-hip ratio (WHR)) for the prediction of CVD risk factors in healthy men and women living in Singapore...
2016: BMC Obesity
https://www.readbyqxmd.com/read/27368124/muscle-strength-differ-between-patients-with-diabetes-and-controls-following-heart-surgery
#17
Marko Boban, Mijana Barisic, Viktor Persic, Drazen Zekanovic, Igor Medved, Marinko Zulj, Aleskandar Vcev
BACKGROUND: The aim of our study was to analyze muscle strength in patients with recent surgical treatment for ischemic and combined ischemic-valvular heart disease, based on existence of diabetes mellitus. Connections existing between muscle strength and patient characteristics or conventional diagnostic tests were analyzed as well. METHODS: Study prospectively included consecutive patients scheduled for cardiovascular rehabilitation 0-3months after heart surgery...
September 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27354072/utility-of-models-to-predict-28-day-or-30-day-unplanned-hospital-readmissions-an-updated-systematic-review
#18
Huaqiong Zhou, Phillip R Della, Pamela Roberts, Louise Goh, Satvinder S Dhaliwal
OBJECTIVE: To update previous systematic review of predictive models for 28-day or 30-day unplanned hospital readmissions. DESIGN: Systematic review. SETTING/DATA SOURCE: CINAHL, Embase, MEDLINE from 2011 to 2015. PARTICIPANTS: All studies of 28-day and 30-day readmission predictive model. OUTCOME MEASURES: Characteristics of the included studies, performance of the identified predictive models and key predictive variables included in the models...
2016: BMJ Open
https://www.readbyqxmd.com/read/27343420/prolonged-utilization-of-proton-pump-inhibitors-in-patients-with-ischemic-and-valvular-heart-disease-is-associated-with-surgical-treatments-weight-loss-and-aggravates-anemia
#19
Marko Boban, Marinko Zulj, Viktor Persic, Igor Medved, Drazen Zekanovic, Aleksandar Vcev
BACKGROUND: Proton pump inhibitors (PPIs) are among the commonest drugs used nowadays. The aim of our study was to analyze prolonged utilization of proton pump inhibitors in medical therapy of patients with ischemic and valvular heart disease. Secondly, profile of utilization was scrutinized to patient characteristics and type of cardiovascular treatments. METHODS: The study included consecutive patients scheduled for cardiovascular rehabilitation 2-6months after index cardiovascular treatment...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27339191/burden-of-disease-resulting-from-lead-exposure-at-toxic-waste-sites-in-argentina-mexico-and-uruguay
#20
Jack Caravanos, Jonathan Carrelli, Russell Dowling, Brian Pavilonis, Bret Ericson, Richard Fuller
BACKGROUND: Though lead contaminated waste sites have been widely researched in many high-income countries, their prevalence and associated health outcomes have not been well documented in low- and middle-income countries. METHODS: Using the well-established health metric disability-adjusted life year (DALY) and an exposure assessment method developed by Chatham-Stephens et al., we estimated the burden of disease resulting from exposure to lead at toxic waste sites in three Latin American countries in 2012: Argentina, Mexico and Uruguay...
2016: Environmental Health: a Global Access Science Source
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