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https://www.readbyqxmd.com/read/28915178/expanding-the-donor-pool-organ-donation-after-brain-death-for-extracorporeal-membrane-oxygenation-patients
#1
Derrick A Christopher, Kenneth J Woodside
No abstract text is available yet for this article.
October 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28903847/dengue-hemorrhagic-fever-arare-cause-of-acute-liver-failure
#2
Aisha Nazeer, Ayesha Aslam Rai, Nasir Hassan Luck, Abbas Ali Yousuf Tasneem
Acute liver failure (ALF) is an acute medical emergency which carries high mortality without liver transplantation. Various hepatotropic viruses, drug induced liver injury, auto immune hepatitis, and metabolic liver diseases are the commonly implicated etiologic agents. Liver involvement in dengue hemorrhagic fever (DHF) is quite common, but acute liver failure is its rare complication. Neurological complications are also commonly seen in DHF. Ateenage girl presented with high grade fever and subconjunctival hemorrhage, and later developed jaundice due to acute liver failure...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28894530/knowledge-and-attitudes-toward-brain-death-and-organ-donation-in-bojnurd
#3
Sima Sadat Hejazi, Shima Nikbakht, Leila Jouybari, Mehdi Hares Abadi, Davood Davoodi, Tooba Hoseini Azizi, Sepideh Yahyaei
BACKGROUND: Organ donation in Iran is common. Bojnurd (North Khorasan, Iran) is a multi-ethnic city, and people with different religions and cultures live together and that could be associated with their behavior and attitude towards health-related issues. So far, no study has taken place on brain death and organ donation in the province of North Khorasan. OBJECTIVE: The aim of this study was to determine the knowledge and attitudes of citizens of Bojnurd toward brain death and organ donation...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28890007/medical-training-and-the-brain-death-exam-a-single-institution-s-experience
#4
Ahmed Kashkoush, Amy Weisgerber, Kiruba Dharaneeswaran, Nitin Agarwal, Lori Shutter
BACKGROUND: Clinicians may have limited opportunities to perform neurological determination of death (NDD; brain death) certification during their training. This study aims to evaluate the level of resident exposure to the brain death exam at a large volume donor hospital. METHODS: In March 2014, we adapted a dual-physician model for NDD certification at our institution to improve resident education regarding NDD. To evaluate the incidence of resident exposure, we collected examiner information from all brain death exams conducted between January 2014 and July 2015...
September 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28886219/comparison-of-outcomes-of-kidney-transplantation-from-donation-after-brain-death-donation-after-circulatory-death-and-donation-after-brain-death-followed-by-circulatory-death-donors
#5
Guodong Chen, Chang Wang, Dicken Shiu-Chung Ko, Jiang Qiu, Xiaopeng Yuan, Ming Han, Changxi Wang, Xiaoshun He, Lizhong Chen
There are three categories of deceased donors of kidney transplantation in China, donation after brain death(DBD), donation after circulatory death(DCD), donation after brain death followed by circulatory death(DBCD) donors. The aim of this study is to compare the outcomes of kidney transplantation from these three categories of deceased donors METHODS: We retrospectively reviewed 469 recipients who received deceased kidney transplantation in our hospital from February 2007 to June 2015. The recipients were divided into three groups according to the source of their donor kidneys: DBD, DCD or DBCD...
September 8, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28885508/defining-benchmarks-in-liver-transplantation-a-multicenter-outcome-analysis-determining-best-achievable-results
#6
Xavier Muller, Francesca Marcon, Gonzalo Sapisochin, Max Marquez, Federica Dondero, Michel Rayar, Majella M B Doyle, Lauren Callans, Jun Li, Greg Nowak, Marc-Antoine Allard, Ina Jochmans, Kyle Jacskon, Magali Chahdi Beltrame, Marjolein van Reeven, Samuele Iesari, Alessandro Cucchetti, Hemant Sharma, Roxane D Staiger, Dimitri A Raptis, Henrik Petrowsky, Michelle de Oliveira, Roberto Hernandez-Alejandro, Antonio D Pinna, Jan Lerut, Wojciech G Polak, Eduardo de Santibañes, Martín de Santibañes, Andrew M Cameron, Jacques Pirenne, Daniel Cherqui, René A Adam, Bö-Göran Ericzon, Bjoern Nashan, Kim Olthoff, Avi Shaked, William C Chapman, Karim Boudjema, Olivier Soubrane, Catherine Paugam-Burtz, Paul D Greig, David R Grant, Amanda Carvalheiro, Paolo Muiesan, Philipp Dutkowski, Milo Puhan, Pierre-Alain Clavien
OBJECTIVE: To propose benchmark outcome values in liver transplantation, serving as reference for assessing individual patients or any other patient groups. BACKGROUND: Best achievable results in liver transplantation, that is, benchmarks, are unknown. Consequently, outcome comparisons within or across centers over time remain speculative. METHODS: Out of 7492 liver transplantation performed in 17 international centers from 3 continents, we identified 2024 low risk adult cases with a laboratory model for end-stage liver disease score ≤20 points, a balance of risk score ≤9, and receiving a primary graft by donation after brain death...
September 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28885491/pancreas-transplantation-with-grafts-from-donors-deceased-after-circulatory-death-dcd-5-years-single-center-experience
#7
Wouter Kopp, Hwai-Ding Lam, A F M Schaapherder, Volkert Huurman, Paul van der Boog, Eelco de Koning, Johan W de Fijter, Andrzej Baranski, Andries Braat
INTRODUCTION: Donation after circulatory death (DCD) pancreas transplantation has been shown to be an additional way to deal with donor organ shortages. The results of 5-year DCD pancreas transplantation are presented. METHODS: A retrospective, single center analysis (2011 - 2015) was performed to compare the results of donation after brain death (DBD) to DCD pancreas transplantation. RESULTS: During the study period, 104 pancreas transplantations (83 from DBD and 21 from DCD) were performed...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28871712/some-quantitative-eeg-features-in-default-mode-resting-state-network-under-general-anaesthesia
#8
Peter Jombík, Michal Drobny, Beata Saniova, Martin Fischer, Petra Kaderjaková, Marianna Lajčiaková, Erika Bakosova, Eva Drobna, Petr Bob, Vladimír Nosáľ
OBJECTIVES: The default mode resting state network (DMRSN) constitutes a circuit which is active in conditions when the subject is at rest. We tested the hypothesis that its function will be altered during unconsciousness. METHODS: Changes in the mean squared coherences in five conventional frequency bands (delta to gamma) in DMRSN during general anaesthesia (GA) were investigated in 39 patients. They were compared with the normal EEG of 86 alert subjects, severely abnormal EEG of 112 patients with dementia and/or encephalopathy, and the mathematical model of brain death...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28859788/outcomes-after-transplantation-of%C3%A2-donor%C3%A2-hearts-with-improving-left%C3%A2-ventricular-systolic%C3%A2-dysfunction
#9
MULTICENTER STUDY
Shivank Madan, Omar Saeed, Peter Vlismas, Ioanna Katsa, Snehal R Patel, Julia J Shin, William A Jakobleff, Daniel J Goldstein, Daniel B Sims, Ulrich P Jorde
BACKGROUND: Left ventricular systolic dysfunction (LVSD) accounts for almost 25% of nonacceptance of potential donor hearts. Previous smaller, single-center studies showed that LVSD following brain death may be transient, and such hearts can be successfully resuscitated with resolution of LVSD, then transplanted. OBJECTIVES: This study evaluated outcomes of donor hearts with LVSD on initial transthoracic echocardiogram (TTE) that resolved during donor management...
September 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28852554/definitions-of-death-brain-death-and-what-matters-in-a-person
#10
Ben Sarbey
No abstract text is available yet for this article.
December 2016: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/28844933/early-detection-of-brain-death-using-the-bispectral-index-bis-in-patients-treated-by-extracorporeal-cardiopulmonary-resuscitation-e-cpr-for-refractory-cardiac-arrest
#11
Romain Jouffroy, Lionel Lamhaut, Alexandra Guyard, Pascal Philippe, Kim An, Christian Spaulding, Frédéric Baud, Pierre Carli, Benoît Vivien
BACKGROUND: Despite increasing use of extracorporeal cardiopulmonary resuscitation (E-CPR) for treatment of refractory cardiac arrest patients, prognosis remains dismal, often resulting in brain-death. However, clinical assessment of brain-death occurence is difficult in post-cardiac arrest patients, sedated, paralyzed, under mild therapeutic hypothermia (MTH). Our objective was to assess the usefulness of Bispectral-Index (BIS) monitoring at bedside for an early detection of brain-death occurrence in refractory cardiac arrest patients treated by E-CPR...
August 24, 2017: Resuscitation
https://www.readbyqxmd.com/read/28844527/a-systematic-review-and-meta-analysis-of-cold-in-situ-perfusion-and-preservation-for-pancreas-transplantation
#12
REVIEW
Ahmer M Hameed, Germaine Wong, Jerome M Laurence, Vincent W T Lam, Henry C Pleass, Wayne J Hawthorne
BACKGROUND: This study aimed to identify the most effective solution for in situ perfusion/preservation of the pancreas in donation after brain death donors, in addition to optimal in situ flush volume(s) and route(s) during pancreas procurement. METHODS: Embase, Medline and Cochrane databases were utilized (1980-2017). Articles comparing graft outcomes between two or more different perfusion/preservation fluids (University of Wisconsin (UW), histidine-tryptophan-ketoglutarate (HTK) and/or Celsior) were compared using random effects models where appropriate...
August 24, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28841633/extracorporeal-circulatory-support-in-acute-coronary-syndromes-a-systematic-review-and-meta-analysis
#13
Rita Pavasini, Chiara Cirillo, Gianluca Campo, Miguel Nobre Menezes, Simone Biscaglia, Elisabetta Tonet, Roberto Ferrari, Brijesh V Patel, Susanna Price
OBJECTIVES: Extracorporeal circulatory support is a life-saving technique, and its use is increasing in acute coronary syndromes. A meta-analysis on pooled event rate of short-term mortality and complications of acute coronary syndrome patients treated with extracorporeal circulatory support was performed. DATA SOURCES: Articles were searched in MEDLINE, Cochrane Library, Google Scholar, and Biomed Central. STUDY SELECTION: Inclusion criteria were observational studies on acute coronary syndrome patients treated with extracorporeal circulatory support...
August 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28836706/the-utility-of-serial-echocardiograms-for-organ-procurement-in-brain-death
#14
Chiara Lazzeri, Cristiana Guetti, Maria Luisa Migliaccio, Marco Ciapetti, Adriano Peris
Heart transplantation rates are limited by a shortage of donor hearts and left ventricular dysfunction is an important cause. We hypothesized that an early echocardiographic evaluation in severe brain injury (performed within 12 hours from ICU admission) could allow the detection of potentially reversible left ventricular (LV) abnormalities and thus the initiation of tailored treatment whose effects could be assessed at a second echocardiogram performed when brain death develops. We assessed this hypothesis in 49 patients with severe brain injury who were potential heart donors...
August 24, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28834180/attitudes-and-barriers-to-the-use-of-dcd-livers-comparison-of-a-u-s-transplant-center-survey-to-the-united-network-for-organ-sharing-data
#15
Linda Sher, Cristiano Quintini, Sameh Adel Fayek, Peter Abt, Mary Lo, Pui Yan, Lingyun Ji, Susan Groshen, Jamie Case, Christopher Lee Marsh
Transplantation of liver grafts from donation after circulatory death (DCD) is limited. To identify barriers of DCD livers utilization, all active United States (U.S.) liver transplant centers (n=138) were surveyed and responses compared to the United Network for Organ Sharing (UNOS) data. Seventy-four centers (54%) responded, and diversity in attitudes was observed, with many not using organ and/or recipient prognostic variables defined in prior studies and UNOS data analysis. Most centers (74%) believed lack of a system allowing a timely re-transplant is a barrier to utilization...
August 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28828924/use-of-ancillary-tests-when-determining-brain-death-in-pediatric-patients-in-the-united-states
#16
Ariane Lewis, Nellie Adams, Arun Chopra, Matthew P Kirschen
Although pediatric brain death guidelines stipulate when ancillary testing should be used during brain death determination, little is known about the way these recommendations are implemented in clinical practice. We conducted a survey of pediatric intensivists and neurologists in the United States on the use of ancillary testing. Although most respondents noted they only performed an ancillary test if the clinical examination and apnea test could not be completed, 20% of 195 respondents performed an ancillary test for other reasons, including (1) to convince a family that objected to the brain death determination that a patient is truly dead (n=21), (2) personal preference (n=14), and (3) institutional requirement (n=5)...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28828556/primary-posterior-fossa-lesions-and-preserved-supratentorial-cerebral-blood-flow-implications-for-brain-death-determination
#17
Panayiotis N Varelas, Paul Brady, Mohammed Rehman, Arash Afshinnik, Chandan Mehta, Tamer Abdelhak, Eelco F Wijdicks
BACKGROUND: Patients with primary posterior fossa catastrophic lesions may clinically meet brain death criteria, but may retain supratentorial brain function or blood flow. These patients could be declared brain-dead in the United Kingdom (UK), but not in the United States of America (USA). We report the outcome of adult patients with primary posterior fossa lesions without concurrent major supratentorial injury. METHODS: Henry Ford Hospital database was reviewed over a period of 88 months in order to identify all adult patients with isolated brainstem or posterior fossa lesions...
August 21, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28826704/application-of-a-three-dimensional-printed-product-to-fill-the-space-after-organ-removal-a-case-report
#18
Jui-Yu Weng, Che-Chuaa Wang, Pei-Jar Chen, Sher-Wei Lim, Jinn-Rung Kuo
BACKGROUND: Maintaining body integrity, especially in Asian societies, is an independent predictor of organ donation. CASE DESCRIPTION: Herein, we report the case of an 18-year-old man who suffered traumatic brain injury with brain death caused by a car accident. According to the family's wishes, we used a three-dimentional (3D) printer to create a simulated heart, kidneys, and liver to fill the spaces after the patient's organs were removed. This is the first case report to introduce this new clinical application of 3D printed products during transplantation surgery...
August 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28822390/physiologic-features-of-brain-death
#19
Eno-Obong Essien, Kristina Fioretti, Thomas M Scalea, Deborah M Stein
Brain death is known to be associated with physiologic derangements but their incidence is poorly described. Knowledge of the changes that occur during brain death is important for management of the potential organ donor. Thus, we sought to characterize the pathophysiology that occurs during brain death in patients with traumatic injuries. All brain-dead patients over a 10-year period were identified from the trauma registry at a level 1 urban trauma center. Patient demographics, injury characteristics, and clinical data for defining organ dysfunction were reviewed for the 24 hours surrounding brain-death declaration...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28815385/stretching-the-boundaries-of-parental-responsibility-and-new-legal-guidelines-for-determination-of-brain-death
#20
Bernadette Richards, Thaddeus Mason Pope
No abstract text is available yet for this article.
August 16, 2017: Journal of Bioethical Inquiry
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