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https://www.readbyqxmd.com/read/27918103/identifying-opportunities-to-increase-organ-donation-after-brain-death-an-observational-study-in-sweden-2009-2014
#1
T Nolin, C Mårdh, G Karlström, S M Walther
BACKGROUND: There is a wide gap between the number of organ donors and patients on waiting lists for transplantation. The purpose of this Swedish nationwide study of the critical pathway for organ donation after brain death (DBD) was to identify missed opportunities for organ donation. METHODS: We performed a prospective, observational study of all ICU deaths in Sweden from Jan 1, 2009 to Dec 31, 2014. The protocol structure followed the critical pathway for organ donation, which was developed and tested during 2008...
January 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27916031/-experience-of-the-selection-and-maintainence-for-donor-lung-62-cases-attached
#2
G L Peng, X Xu, D X Huang, B Wei, D Xiao, W Wang, Y D Wang, J X He
Objective: To summarize the experience of selection and maintainence for the lungs from donation. Methods: From January 2015 to June 2016, 62 cases had been evaluated by Department of Thoracic Surgery, First Affiliated Hospital of Guangzhou Medical University. All the clinic data had been collected to evaluate the donor lungs, including the basic information, physical examination, results of radiology and laboratory, the bronchoscope, etc. All the satisfactory donors had been harvested and transplanted to the receipient and then follow up...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27916030/-short-term-outcomes-of-lung-transplant-recipients-using-organs-from-brain-death-donors
#3
W X He, C Jiang, X G Liu, W Huang, C Chen, L Jiang, B Yang, K Wu, Q K Chen, Y Yang, Y M Yu, G N Jiang
Objective: To assess short-term outcomes after lung transplantation with organs procured following brain death. Methods: Between April 2015 and July 2016, all 17 recipients after lung transplantation using organs from brain death donors (DBD) at Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine were enrolled in this study. All patients were male, aging (60±7) years, including 11 chronic obstructive pulmonary disease, 5 idiopathic pulmonary fibrosis, 1 silicosis...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27909606/knowledge-levels-and-attitudes-of-people-living-in-the-city-centre-of-nev%C3%A5-ehir-on-organ-donation-and-transplantation
#4
Mehmet Akif Yazar, Mehmet Barış Açıkgöz
OBJECTIVE: The purpose of this descriptive study was to determine the knowledge levels and attitudes of people living in Nevşehir on organ donation (OD) and transplantation. METHODS: Data were collected using a questionnaire administered to 414 people residing in Nevşehir between February and May 2016. The primary and secondary endpoints of the present study were to determine the attitudes and knowledge levels of participants on OD and transplantation, respectively...
October 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27908468/-the-history-of-kidney-transplantation
#5
Michèle Kessler
Medical advances which have marked the history of transplantation include the work of Jean Dausset on the HLA system from 1952, brain death described in 1959 and prolonged organ preservation. This article looks back at the major turning points.
December 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/27907967/modern-approach-to-brain-death
#6
Panayiotis N Varelas, Ariane Lewis
People die either when their heart and respiration stop or when their brain irreversibly stops functioning. This latter mode of death by neurologic criteria (also called brain death) emerged after the development of ventilators and intensive care units in the late 1950s and 1960s. Brain death is universally accepted as a modern entity, but the complex process for declaring a patient brain dead is not uniformly followed across country and state lines or even hospital policies, creating unacceptable variability and risks for falsely pronouncing a patient dead...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27906826/factors-associated-with-short-and-long-term-liver-graft-survival-in-the-united-kingdom-development-of-a-uk-donor-liver-index
#7
Dave Collett, Peter J Friend, Christopher Je Watson
BACKGROUND: A measure of donor liver quality, the donor liver index, was developed and validated for the UK population of transplant recipients. Unlike previously proposed measures, this index is only based on variables that are available at the point of retrieval, and so does not include cold ischaemic time. METHODS: Indices of liver quality were based on data from the UK Transplant Registry on all 7929 liver transplants between January 2000 and December 2014. RESULTS: The donor liver index (DLI) was based on factors shown to affect graft survival, which included donor age, sex, height, type (donor after brain death or circulatory death), bilirubin, smoking history, and whether the liver was split...
December 1, 2016: Transplantation
https://www.readbyqxmd.com/read/27900758/99mtc-hmpao-perfusion-spect-ct-in-the-diagnosis-of-brain-death
#8
Thorsten Derlin, Desiree Weiberg
This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27864895/the-postreperfusion-syndrome-is-associated-with-acute-kidney-injury-following-donation-after-brain-death-liver-transplantation
#9
Marit Kalisvaart, Jubi E de Haan, Dennis A Hesselink, Wojciech G Polak, Bettina E Hansen, Jan N M IJzermans, Diederik Gommers, Herold J Metselaar, Jeroen de Jonge
Acute kidney injury (AKI) is frequently observed after DBD liver transplantation (LT) and associated with impaired recipient survival and chronic kidney disease. Hepatic ischemia/reperfusion injury (IRI) is suggested to be an important factor in this process. The postreperfusion syndrome (PRS) is the first manifestation of severe hepatic IRI directly after reperfusion. We performed a retrospective study on the relation between hepatic IRI and PRS and their impact on AKI in 155 DBD LT recipients. Severity of hepatic IRI was measured by peak postoperative AST levels and PRS was defined as >30% decrease in MAP ≥1 minute <5 minutes after reperfusion...
November 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27853826/brain-perfusion-spect-for-brain-death-assessment
#10
Pedro Barata Silva Coelho, Ana Fernandes, Ana Oliveira, Teresa Faria, Jorge Pereira
No abstract text is available yet for this article.
November 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27853394/long-term-impact-after-fulminant-guillain-barr%C3%A3-syndrome-case-report-and-literature-review
#11
Alain Rougé, Jérémie Lemarié, Sébastien Gibot, Pierre Edouard Bollaert
A 47-year-old man was admitted to the intensive care unit a few hours after presenting to emergency department with acute diplopia and dysphonia. Swallowing disorders and respiratory muscular weakness quickly required invasive ventilation. On day 3, the patient was in a "brain-death"-like state with deep coma and absent brainstem reflexes. Electroencephalogram ruled out brain death diagnosis as a paradoxical sleep trace was recorded. Cerebrospinal fluid analysis, electrophysiologic studies, and a recent history of diarrhea led to the diagnosis of Campylobacter jejuni-related fulminant Guillain-Barré syndrome (GBS) mimicking brain death...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27851527/1892-ventilator-autotriggering-in-a-patient-following-massive-intracerebral-hemorrhage-and-brain-death
#12
Richard Arbour, Chet Morrison
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850675/1037-apnea-testing-for-brain-death-arterial-versus-venous-pco2
#13
Ezekiel Tayler, Helen Stutz, Sophia Socaris, Michael Gruenthal, Raymond Walsh, Paul Feustel, Kareem Kassel
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850015/375-a-needs-assessment-of-brain-death-education-in-pediatric-critical-care-medicine-fellowships
#14
Andrew Ausmus, Tara Petersen, Pippa Simpson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849741/61-direct-peritoneal-resuscitation-reduces-macrophages-and-neutrophils-in-kidneys-after-brain-death
#15
Jessica Weaver, Paul Matheson, Amy Matheson, Cynthia Downard, Neal Garrison, Jason Smith
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27835640/mass-spectrometry-based-metabolomics-comparison-of-liver-grafts-from-donors-after-circulatory-death-dcd-and-donors-after-brain-death-dbd-used-in-human-orthotopic-liver-transplantation
#16
Olga Hrydziuszko, M Thamara P R Perera, Richard Laing, Jennifer Kirwan, Michael A Silva, Douglas A Richards, Nick Murphy, Darius F Mirza, Mark R Viant
Use of marginal liver grafts, especially those from donors after circulatory death (DCD), has been considered as a solution to organ shortage. Inferior outcomes have been attributed to donor warm ischaemic damage in these DCD organs. Here we sought to profile the metabolic mechanisms underpinning donor warm ischaemia. Non-targeted Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry metabolomics was applied to biopsies of liver grafts from donors after brain death (DBD; n = 27) and DCD (n = 10), both during static cold storage (T1) as well as post-reperfusion (T2)...
2016: PloS One
https://www.readbyqxmd.com/read/27833207/brain-death-and-true-patient-care
#17
Doyen Nguyen
The "brain death" standard as a criterion of death is closely associated with the need for transplantable organs from heart-beating donors. Are all of these potential donors really dead, or does the documented evidence of patients destined for organ harvesting who improve, or even recover to live normal lives, call into question the premise underlying "brain death"? The aim of this paper is to re-examine the notion of "brain death," especially its clinical test-criteria, in light of a broad framework, including medical knowledge in the field of neuro-intensive care and the traditional ethics of the medical profession...
August 2016: Linacre Quarterly
https://www.readbyqxmd.com/read/27833198/a-philosophical-assessment-of-tk-s-autopsy-report-implications-for-the-debate-over-the-brain-death-criteria
#18
Nicanor Pier Giorgio Austriaco
: In recent years, there has been increasing evidence that the totally brain-dead patient is able to continue to live and to maintain some integrated functions, albeit with the necessary assistance of mechanical ventilation. Several years ago, the autopsy report of a totally brain-dead patient named TK who was kept on life support for nearly twenty years was published in the Journal of Child Neurology. He remains the individual kept on life support the longest after suffering total brain failure...
May 2016: Linacre Quarterly
https://www.readbyqxmd.com/read/27829715/organ-donation-after-brain-death-in-india-a-trained-intensivist-is-the-key-to-success
#19
Vijayanand Palaniswamy, Suganya Sadhasivam, Cibi Selvakumaran, Priyadharsan Jayabal, S R Ananth
Organ donation after brain death in India is gaining momentum but only in a few states. Tamil Nadu is leading in the country in this regard. Certain cities have performed well compared to Chennai's results. A single tertiary hospital performed 28 donations in a 17 months period with a team of an intensivist and a transplant coordinator. An intensivist needs training and interest in this noble cause. There is no formal training program in this noble cause for doctors in India. A structured formal training needs to be introduced and made mandatory for the doctors in intensive care to make this donation process a successful program...
October 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27829654/minimally-conscious-state-evolution-of-concept-diagnosis-and-treatment
#20
Ricardo Hodelín-Tablada
The study of consciousness disorders is a scientific challenge, and clinical differentiation among the various sorts of alterations in consciousness is difficult. Persistent vegetative state was defined in 1972, but years later cases appeared in which diagnosed patients showed signs of cognitive activity, and therefore could not be considered vegetative. Minimally conscious state was defined in 2002. This article discusses minimally conscious state based on a literature review and the author's clinical experience...
October 2016: MEDICC Review
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