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Left atrial dilatation

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https://www.readbyqxmd.com/read/28212578/interleukin-1%C3%AE-levels-predict-long-term-mortality-and-need-for-heart-transplantation-in-ambulatory-patients-affected-by-idiopathic-dilated-cardiomyopathy
#1
Aneta Aleksova, Antonio Paolo Beltrami, Cosimo Carriere, Giulia Barbati, Pierluigi Lesizza, Martina Perrieri-Montanino, Miriam Isola, Piero Gentile, Elisabetta Salvioni, Tarcisio Not, Piergiuseppe Agostoni, Gianfranco Sinagra
AIMS: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients. METHODS AND RESULTS: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28202256/transseptal-puncture-review-of-anatomy-techniques-complications-and-challenges
#2
REVIEW
Barry O'Brien, Haroon Zafar, Simon De Freitas, Faisal Sharif
In recent years, the transseptal puncture approach has enabled passage of increasingly large and complex devices into the left atrium. Traditional tools remain effective in creating and dilating the initial puncture, with an acceptable safety profile. Even for skilled operators, the procedure is technically demanding and requires sound understanding of atrial anatomy. Intracardiac echocardiography is useful in cases of previous septal repair, poorly defined fossa ovalis anatomy or when considering patent foramen ovale portal crossing...
February 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28188213/non-invasive-stratification-of-postinfarction-rats-based-on-degree-of-cardiac-dysfunction-using-magnetic-resonance-imaging-and-echocardiography
#3
Jan Magnus Aronsen, Emil Knut Stenersen Espe, Kristine Skårdal, Almira Hasic, Lili Zhang, Ivar Sjaastad
The myocardial infarction (MI) rat model plays a crucial role in modern cardiovascular research, but the inherent heterogeneity of this model represents a challenge. We sought to identify subgroups among the post-MI rats, and establish simple non-invasive stratification protocols for such subgroups. Six weeks after induction of MI, 49 rats underwent non-invasive examinations using magnetic resonance imaging (MRI) and echocardiography. 12 sham-operated rats served as controls. Increased end-diastolic left ventricular (LV) pressure and lung weight served as indicators for congestive heart failure (CHF)...
February 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28171858/exome-sequencing-identifies-a-novel-des-mutation-r227c-in-a-chinese-dilated-cardiomyopathy-family
#4
Rong Yu, Lv Liu, Chan Chen, Jin-Mei Shen
OBJECTIVES: Dilated cardiomyopathy (DCM) is a common disease in the clinic, and it is the leading cause of heart failure and sudden cardiac death. Previous studies have proven that genetic factors play a crucial role in the occurrence of DCM; more than 50 disease genes including desmin (DES) have been identified to be associated with DCM. At present, most DES mutations are reported in desmin-related myofibrilla myopathy patients, but variants leading to isolated DCM are rarely reported...
February 8, 2017: Cardiology
https://www.readbyqxmd.com/read/28153949/factors-associated-with-left-atrial-remodeling-in-the-general-population
#5
Walter Oliver, Gwendolyn Matthews, Colby R Ayers, Sonia Garg, Sachin Gupta, Ian J Neeland, Mark H Drazner, Jarett D Berry, Susan Matulevicius, James A de Lemos
BACKGROUND: Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts, few data are available describing factors influencing changes in left atrial (LA) structure. METHODS AND RESULTS: Maximum LA volume was determined by cardiac magnetic resonance imaging among 748 participants in the Dallas Heart Study at 2 visits a mean of 8 years apart. Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac magnetic resonance imaging and detailed measurements of global and regional adiposity (by magnetic resonance imaging and dual-energy x ray absorptiometry) were assessed using multivariable linear regression...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28148779/adverse-left-ventricular-remodeling-by-glycoprotein-nonmetastatic-melanoma-protein-b-in-myocardial-infarction
#6
Anne Järve, Silke Mühlstedt, Fatimunnisa Qadri, Bernadette Nickl, Herbert Schulz, Norbert Hübner, Cemil Özcelik, Michael Bader
Cardiac diseases are the leading cause of death. Available treatment approaches are not sufficient to reverse persistent cardiac damage after injury; thus, the search for new therapeutic targets is essential. Our microarray-based screening in rat hearts 24 h after myocardial infarction (MI) yielded glycoprotein nonmetastatic melanoma protein B (GPNMB), which is known to be involved in inflammation and fibrosis after tissue injury. However, its role in the heart was elusive. We found increased cardiac expression levels of GPNMB in rats and mice after MI...
February 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28143995/ebstein-anomaly-in-pregnancy
#7
Lusiani Rusdi, Syahrir Azizi, Christopher Suwita, Astrid Karina, Sally A Nasution
: A 27-year-old primiparous woman with 28 weeks gestational age was admitted to our hospital with worsening shortness of breath. She was diagnosed with Ebstein's anomaly three years ago, but preferred to be left untreated. The patient was not cyanotic and her vital signs were stable. Her ECG showed incomplete RBBB and prolonged PR-interval. Blood tests revealed mild anemia. Observation of two-dimensional echo with color flow Doppler study showed Ebstein's anomaly with PFO as additional defects, EF of 57%, LV and LA dilatation, RV atrialization, severe TR, and moderate PH with RVSP of 44...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28118147/evaluation-of-nt-probnp-in-children-with-heart-failure-younger-than-3-years-old
#8
Daniela Iacob, Angela Butnariu, Daniel-Corneliu Leucuţa, Gabriel Samaşca, Diana Deleanu, Iulia Lupan
INTRODUCTION: Heart failure (HF) is characterized by neuroendocrine activation. The cardiac natriuretic hormones, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), together with their related pro-peptides (proANP and proBNP) represent a group of peptide hormones produced by the heart. A normal NT-proBNP level has a high negative predictive value for heart failure. The use of NT-proBNP testing is helpful in diagnosing acute HF in the emergency care setting, allowing an early and optimal treatment...
January 23, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28115807/functional-remodeling-of-both-atria-is-associated-with-occurrence-of-stroke-in-patients-with-paroxysmal-and-persistent-atrial-fibrillation
#9
Hsuan-Ming Tsao, Wei-Chih Hu, Ping-Huang Tsai, Chao-Lin Lee, Hsueh-Han Wang, Shih-Lin Chang, Tze-Fan Chao, Shih-Ann Chen
BACKGROUND: It is critical to recognize high risk patients who are prone to develop stroke in the management of atrial fibrillation (AF). The purpose of this study was to identify the determinants of AF related stroke by assessing the anatomical and functional remodeling of cardiac chambers. METHODS: We compared the cardiac structure and function of 28 consecutive patients with paroxysmal and persistent AF-related stroke with 69 patients with AF and 21 controls without stroke using contrast-enhanced 64-slice multi-detector computed tomography during sinus rhythm...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28109125/evaluation-of-left-atrial-function-via-two-dimensional-speckle-tracking-echocardiography-in-patients-with-coronary-artery-ectasia
#10
Hasan Aghajani, Mohsen Faal, Ali Hosseinsabet, Reza Mohseni-Badalabadi
BACKGROUND: Coronary artery ectasia (CAE) is a segmental dilation of an epicardial coronary artery. Our aim was to evaluate the left atrial (LA) function in patients with CAE. METHODS: Twenty-seven consecutive patients with CAE and 33 subjects without significant coronary artery disease were included in our study. LA function was evaluated with two-dimensional speckle-tracking echocardiography (2DSTE). RESULTS: The systolic, early diastolic and late diastolic strains and strain rates were not statistically significantly different between the two groups...
January 21, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28094152/use-of-3d-printer-technology-to-facilitate-surgical-correction-of-a-complex-vascular-anomaly-with-esophageal-entrapment-in-a-dog
#11
A Dundie, G Hayes, P Scrivani, L Campoy, D Fletcher, K Ash, E Oxford, N S Moïse
A 10 week old female intact Staffordshire terrier was presented with a total of five congenital cardio-thoracic vascular anomalies consisting of a patent ductus arteriosus (PDA) with an aneurysmic dilation, pulmonic stenosis, persistent right aortic arch, aberrant left subclavian artery and persistent left cranial vena cava. These abnormalities were identified with a combination of echocardiogram and computed tomography angiography (CTA). The abnormalities were associated with esophageal entrapment, regurgitation, and volume overload of the left heart with left atrial and ventricular enlargement...
January 13, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28090009/prognostic-impact-of-atrial-fibrillation-and-new-risk-score-of-its-onset-in-patients-at-high-risk-of-heart-failure%C3%A3-a-report-from-the-chart-2-study
#12
Takeshi Yamauchi, Yasuhiko Sakata, Masanobu Miura, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Kotaro Nochioka, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
BACKGROUND: The prognostic impact of atrial fibrillation (AF) among patients at high risk for heart failure (HF) remains unclear. In addition, there is no risk estimation model for AF development in these patients.Methods and Results:The present study included 5,382 consecutive patients at high risk of HF enrolled in the CHART-2 Study (n=10,219). At enrollment, 1,217 (22.6%) had AF, and were characterized, as compared with non-AF patients, by higher age, lower estimated glomerular filtration rate, higher B-type natriuretic peptide (BNP) level and lower left ventricular ejection fraction...
January 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28080919/restrictive-cardiomyopathy-and-secondary-congestive-heart-failure-in-a-mcdowell-s-carpet-python-morelia-spilota-mcdowelli
#13
Lionel Schilliger, Valérie Chetboul, Cécile Damoiseaux, Alexandra Nicolier
Echocardiography is an established and noninvasive diagnostic tool used in herpetologic cardiology. Various cardiac lesions have been previously described in reptiles with the exception of restrictive cardiomyopathy. In this case report, restrictive cardiomyopathy and congestive heart failure associated with left atrial and sinus venosus dilation were diagnosed in a 2-yr-old captive lethargic McDowell's carpet python ( Morelia spilota mcdowelli), based on echocardiographic, Doppler, and histopathologic examinations...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28073806/functional-tricuspid-regurgitation-caused-by-chronic-atrial-fibrillation-a-real-time-3-dimensional-transesophageal-echocardiography-study
#14
Hiroto Utsunomiya, Yuji Itabashi, Hirotsugu Mihara, Javier Berdejo, Sayuki Kobayashi, Robert J Siegel, Takahiro Shiota
BACKGROUND: Functional tricuspid regurgitation (TR) with a structurally normal tricuspid valve (TV) may occur secondary to chronic atrial fibrillation (AF). However, the clinical and echocardiographic differences according to functional TR subtypes are unclear. Therefore, characterization of functional TR because of chronic AF (AF-TR) remains undetermined. METHODS AND RESULTS: To investigate the prevalence of AF-TR, 437 patients with moderate to severe TR underwent 3-dimensional (3D) transesophageal echocardiography...
January 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28049601/validation-of-left-atrial-volume-estimation-by-left-atrial-diameter-from-the-parasternal-long-axis-view
#15
Grazia Canciello, Giovanni de Simone, Raffaele Izzo, Alessandra Giamundo, Filomena Pacelli, Costantino Mancusi, Maurizio Galderisi, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Measurement of left atrial (LA) volume (LAV) is recommended for quantification of LA size. Only LA anteroposterior diameter (LAd) is available in a number of large cohorts, trials, or registries. The aim of this study was to evaluate whether LAV may be reasonably estimated from LAd. METHODS: One hundred forty consecutive patients referred to our outpatient clinics were prospectively enrolled to measure LAd from the long-axis view on two-dimensional echocardiography...
December 31, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28017577/ebstein-s-anomaly-genetics-clinical-manifestations-and-management
#16
REVIEW
Shi-Min Yuan
Ebstein's anomaly is uncommon. Genetic bases of this congenital heart defect may be related to the mutations in myosin heavy chain 7 and NKX2.5, among others. Asymptomatic patients with Ebstein's anomaly can be conservatively treated and kept under close follow-up, whereas surgical operation is indicated for those patients with evidence of right heart dilation and progressively impaired ventricular systolic function. A biventricular repair consisting of the reconstruction of a competent monocuspid tricuspid valve, right ventriculorrhaphy, subtotal atrial septal defect closure, and aggressive reduction atrioplasty is suitable for most patients, and 1...
November 19, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28011759/-end-stage-heart-failure-therapy-potential-lessons-from-congenital-heart-disease-from-pulmonary-artery-banding-and-interatrial-communication-to-parallel-circulation
#17
REVIEW
Dietmar Schranz, Hakan Akintuerk, Norbert F Voelkel
The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Based on pathophysiological insights regarding (1) the long-term impact of an obstructive pulmonary outflow tract in neonates with congenitally corrected transposition of the great arteries, (2) the importance of a restrictive versus a non-restrictive atrial septum in neonates born with a borderline left ventricle and (3) the significance of both, a patent foramen ovale and/or open ductus arteriosus for survival of newborns with persistent pulmonary hypertension, the current review introduces some therapeutical strategies that may be applicable to selected patients with heart failure...
February 15, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27989041/left-atrial-and-left-ventricular-function-and-remodeling-following-percutaneous-mitral-valve-repair
#18
Christos Rammos, Tobias Zeus, Jan Balzer, Verena Veulemans, Katharina Hellhammer, Svenja Niebel, Malte Kelm, Tienush Rassaf
BACKGROUND: Mitral regurgitation causes left atrial (LA) and left ventricular (LV) dysfunction, dilatation, and remodeling. Following percutaneous mitral valve repair (PMVR) using the MitraClip® approach, reverse cardiac remodeling is desirable. To date, the influence of PMVR on LA and segmental LV function and remodeling has not been investigated in detail. METHODS: Twenty-six patients who received the MitraClip device were enrolled in an open-label, single-center observational study...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27939353/three-dimensional-diastolic-blood-flow-in-the-left-ventricle
#19
Seyed Saeid Khalafvand, Eddie Yin-Kwee Ng, Liang Zhong, Tin-Kan Hung
Three-dimensional blood flow in a human left ventricle is studied via a computational analysis with magnetic resonance imaging of the cardiac motion. Formation, growth and decay of vortices during the myocardial dilation are analyzed with flow patterns on various diametric planes. They are dominated by momentum transfer during flow acceleration and deceleration through the mitral orifice. The posterior and anterior vortices form an asymmetric annular vortex at the mitral orifice, providing a smooth transition for the rapid inflow to the ventricle...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27938454/cardiac-manifestations-of-congenital-lmna-related-muscular-dystrophy-in-children-three-case-reports-and-recommendations-for-care
#20
Felice Heller, Ivana Dabaj, Jean K Mah, Jean Bergounioux, Aben Essid, Carsten G Bönnemann, Anne Rutkowski, Gisèle Bonne, Susana Quijano-Roy, Karim Wahbi
Skeletal and cardiac muscle laminopathies, caused by mutations in the lamin A/C gene, have a clinical spectrum from congenital LMNA-related muscular dystrophy to later-onset Emery-Dreifuss muscular dystrophy, limb girdle muscular dystrophy, and dilated cardiomyopathy. Although cardiac involvement is observed at all ages, it has only been well described in adults. We present the evolution of cardiac disease in three children with congenital muscular dystrophy presentation of LMNA-related muscular dystrophy. In this series, atrial arrhythmia was the presenting cardiac finding in all three patients...
December 12, 2016: Cardiology in the Young
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