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T Takeshima, T Takahashi, J Yamashita, Y Okada, S Watanabe
Multi-emitter fitting algorithms have been developed to improve the temporal resolution of single-molecule switching nanoscopy, but the molecular density range they can analyse is narrow and the computation required is intensive, significantly limiting their practical application. Here, we propose a computationally fast method, wedged template matching (WTM), an algorithm that uses a template matching technique to localise molecules at any overlapping molecular density from sparse to ultrahigh density with subdiffraction resolution...
May 25, 2018: Journal of Microscopy
Anton Khmelnitskiy, Adam Kell, Tonu Reinot, Rafael G Saer, Robert E Blankenship, Ryszard Jankowiak
We discuss the excitonic energy landscape of the typically studied wild-type (WT) Fenna-Matthews-Olson (FMO) antenna protein from the green sulfur bacterium Chlorobaculum tepidum (referred to as WTM ), which is described as a mixture of intact (WTI ) and destabilized (WTD ) complexes. Optical spectra of WTM and the L122Q mutant (where leucine 122 near BChl 8 is replaced with glutamine) are compared to WTI FMO. We show that WTM and L122Q samples are mixtures of two subpopulations of proteins, most likely induced by protein conformational changes during the isolation/purification procedures...
March 2018: Biochimica et Biophysica Acta
Gaetano Iaquaniello, Gabriele Centi, Annarita Salladini, Emma Palo, Siglinda Perathoner, Luca Spadaccini
The waste-to-methanol (WtM) process and related economics are assessed to evidence that WtM is a valuable solution both from economic, strategic and environmental perspectives. Bio-methanol from Refuse-derived-fuels (RdF) has an estimated cost of production of about 110€/t for a new WtM 300t/d plant. With respect to waste-to-energy (WtE) approach, this solution allows various advantages. In considering the average market cost of methanol and the premium as biofuel, the WtM approach results in a ROI (Return of Investment) of about 29%, e...
November 2017: Bioresource Technology
Giovanna Longhi, Alberto Ceselli, Sandro L Fornili, Vincenzo Turco Liveri
The behavior of aqueous solutions of sodium bis(2-ethylhexyl)sulfosuccinate (AOTNa) under conditions of electrospray ionization (ESI) has been investigated by molecular dynamics (MD) and well-tempered metadynamics (WTM) simulations at 300 K and 400 K. We have examined water droplets with initial fixed numbers of water molecules (1000) and AOT(-) anions (100), and with sodium cations in the range of 70-130. At 300 K, all charged droplets show the water evaporation rate increasing with the absolute value of the initial droplet charge state (Z), accompanied by ejection of an increasing number of solvated sodium ions or by expulsion of AOT(-) anions depending on the sign of Z and by fragmentation in the case of high |Z|...
May 28, 2017: Journal of Chemical Physics
Joel C Miller
In recent years, many variants of percolation have been used to study network structure and the behavior of processes spreading on networks. These include bond percolation, site percolation, k-core percolation, bootstrap percolation, the generalized epidemic process, and the Watts threshold model (WTM). We show that-except for bond percolation-each of these processes arises as a special case of the WTM, and bond percolation arises from a small modification. In fact "heterogeneous k-core percolation," a corresponding "heterogeneous bootstrap percolation" model, and the generalized epidemic process are completely equivalent to one another and the WTM...
September 2016: Physical Review. E
Ying-Chu Chen
Energy recovery and greenhouse gas (GHG) emissions from wastes are getting noticed in recent years. This study evaluated the potential for energy recovery and GHG mitigation from municipal solid waste (MSW) with a waste-to-material (WTM) approach. Waste generated in Taiwan contains a large amount of paper, food waste, and plastics, which previously were mostly sent to waste-to-energy (WTE) plants for incineration. However, the mitigation of GHGs by the WTM approach has been especially successful in the recycling of metals (averaging 1...
December 2016: Waste Management
Hao Zhou, Yali Ran, Qi Da, Tanner S Shaw, Dan Shang, Anilkumar K Reddy, José A López, Christie M Ballantyne, Jerry Ware, Huaizhu Wu, Yuandong Peng
Localization of the platelet glycoprotein Ib-IX complex to the membrane lipid domain is essential for platelet adhesion to von Willebrand factor and subsequent platelet activation in vitro. Yet, the in vivo importance of this localization has never been addressed. We recently found that the disulfide linkage between Ibα and Ibβ is critical for the association of Ibα with the glycosphingolipid-enriched membrane domain; in this study, we established a transgenic mouse model expressing this mutant human Ibα that is also devoid of endogenous Ibα (HαSSMα(-/-))...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Andrew Smart, Eric Harrison
Objectives . The paper investigates differences in engagement with medical research between White British and Black, Asian and Minority Ethnic (BAME) groups in the UK, using data from the Wellcome Trust Monitor (WTM). DESIGN: The study used two waves of the WTM (n = 2575) to examine associations between ethnic group and participation in medical research, and willingness to participate (WP) in medical research. Logistic regression models controlled for socio-economic and demographic factors, and relevant outlooks and experiences that are assumed to be markers of engagement...
February 2017: Ethnicity & Health
Sebastián E Sabatini, Beatríz M Brena, Macarena Pirez, María Del Carmen Ríos de Molina, Carlos M Luquet
We studied the accumulation and depuration of microcystin-LR (MCLR) in the hepatopancreas of the crab Neohelice granulata fed twice weekly with either non toxic or MCLR-producing Microcystis aeruginosa (strain NPDC1 or NPJB, respectively) during seven weeks. We also analyzed MCLR effects on the oxidative stress- and detoxification-related variables, superoxide dismutase and glutathione-S-transferase activities, and the levels of reduced glutathione and lipid peroxidation (as thiobarbituric acid reactive substances, TBARS)...
October 2015: Ecotoxicology and Environmental Safety
Yisa S Rumala
The wave transfer matrix (WTM) is applied to calculating various characteristics of a spiral phase plate (SPP) for the first time to our knowledge. This approach provides a more convenient and systematic approach to calculating properties of a multilayered SPP device. In particular, it predicts the optical wave characteristics on the input and output plane of the device when the SPP is fabricated on a substrate of the same refractive index as the SPP as well as on a substrate of a different refractive index compared to the SPP...
May 10, 2015: Applied Optics
Raquel Romay-Tallon, Tania Rivera-Baltanas, Lisa E Kalynchuk, Hector J Caruncho
Repeated corticosterone (CORT) treatment induces a deficit in dentate gyrus subgranular zone reelin-positive cells, in maturation of newborn neurons, and results in a consistent depressive-like behavior. However, the molecular mechanisms underlying these processes are not known in detail. The purpose of the present study was to characterize the effect of three weeks of 20mg/kg CORT injections in the number of reelin and neuronal nitric oxide synthase (nNOS), as well as their colocalization, in hippocampal regions in wild type (WTM) and heterozygous reeler mice (HRM)...
January 12, 2015: Brain Research
Tinggui Chen, Renbin Xiao
Due to fierce market competition, how to improve product quality and reduce development cost determines the core competitiveness of enterprises. However, design iteration generally causes increases of product cost and delays of development time as well, so how to identify and model couplings among tasks in product design and development has become an important issue for enterprises to settle. In this paper, the shortcomings existing in WTM model are discussed and tearing approach as well as inner iteration method is used to complement the classic WTM model...
2014: Computational Intelligence and Neuroscience
Wolfgang P J Dittus
There is a paucity of information on body composition and fat patterning in wild nonhuman primates. Dissected adipose tissue from wild toque macaques (Macaca sinica) (WTM), feeding on a natural diet, accounted for 2.1% of body weight. This was far less than fatness reported for nonhuman primates raised in captivity or for contemporary humans. In WTM, fatness increased with age and diet richness, but did not differ by sex. In WTM (none of which were obese) intra-abdominal fat filled first, and "excess" fat was stored peripherally in a ratio of about 6:1...
November 2013: American Journal of Physical Anthropology
Sung Yong Park, Ingrid Undeland, Thippeswamy Sannaveerappa, Mark P Richards
Caffeic acid (CA) accelerated methemoglobin (Hb) formation at pH5.8 and 25°C. This was attributed to electron donation from CA to liganded O2 in Hb. CA inhibited hemin dissociation from metHb. Pig Hb remained mostly as oxyHb and did not promote lipid oxidation in washed cod muscle (WCM) nor washed turkey muscle (WTM) during iced storage at pH5.8. Conversely, perch Hb rapidly was converted to metHb and readily promoted lipid oxidation based on lipid peroxide and hexanal formation. CA strongly inhibited perch Hb-mediated lipid oxidation during storage...
September 2013: Meat Science
X Zhou, J L Roehl, C Lind, S V Khare
We have studied the pressure-induced phase transitions from NaCl-type (B1) to CsCl-type (B2) structure in BaS, BaSe and BaTe by using ab initio density functional theory computations in the local density approximation. The Buerger and WTM mechanisms were explored by mapping the enthalpy contours in two- and four-dimensional configuration space for the two mechanisms, respectively. Transition pressures for BaS, BaSe and BaTe were determined to be 5.5 GPa, 4.9 GPa and 3.4 GPa, respectively. From these configuration space landscapes, a low enthalpy barrier path was constructed for the transitions to proceed at three different pressures...
February 20, 2013: Journal of Physics. Condensed Matter: An Institute of Physics Journal
J P Bidanel, A Rosendo, N Iannuccelli, J Riquet, H Gilbert, J C Caritez, Y Billon, Y Amigues, A Prunier, D Milan
A quantitative trait locus (QTL) analysis of female reproductive data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six F1 boars and 23 F1 sows, progeny of six LW boars and six MS sows, produced 573 F2 females and 530 F2 males. Six traits, i.e. teat number (TN), age at puberty (AP), ovulation rate (OR), weight at mating (WTM), number of viable embryos (NVE) and embryo survival (ES) at 30 days of gestation were analysed. Animals were genotyped for a total of 137 markers covering the entire porcine genome...
June 2008: Animal: An International Journal of Animal Bioscience
William R Lloyd, Robert H Wilson, Ching-Wei Chang, Gregory D Gillispie, Mary-Ann Mycek
A fiber-optic system was developed to rapidly acquire tissue fluorescence wavelength-time matrices (WTMs) with high signal-to-noise ratio (SNR). The essential system components (473 nm microchip laser operating at 3 kHz repetition frequency, fiber-probe assemblies, emission monochromator, photomultiplier tube, and digitizer) were assembled into a compact and clinically-compatible unit. Data were acquired from fluorescence standards and tissue-simulating phantoms to test system performance. Fluorescence decay waveforms with SNR > 100 at the decay curve peak were obtained in less than 30 ms...
2010: Biomedical Optics Express
Duy Xuan Ho, Ki-Hyun Kim
In this study, the feasibility of ternary mobile phases was examined in a high-performance liquid chromatography (HPLC)-based analysis of carbonyl compounds (CCs). To test the performance of different ternary phases, the liquid phase standards containing a 15 aldehyde/ketone-DNPH(o) mix were analyzed through a series of five-point calibration experiments. For this comparison, three types of ternary mobile phases were prepared initially by mixing water (W) with two of the following three organic solvents: isopropanol (I), methanol (M), and tetrahydrofuran (T)...
January 5, 2011: TheScientificWorldJournal
Thomas I Dearing, Jeremy S Nadeau, Brian G Rohrback, L Scott Ramos, Robert E Synovec
An improved method for real-time selection of the target for the alignment of gas chromatographic data is described. Further outlined is a simple method to determine the accuracy of the alignment procedure. The target selection method proposed uses a moving window of aligned chromatograms to generate a target, herein referred to as the window target method (WTM). The WTM was initially tested using a series of 100 simulated chromatograms, and additionally evaluated using a series of 55 diesel fuel gas chromatograms obtained with four fuel samples...
January 15, 2011: Talanta
April L Lussier, Raquel Romay-Tallón, Lisa E Kalynchuk, Hector J Caruncho
We examined a potential two-hit murine animal model of depression by assessing whether a genetic deficit in reelin increases vulnerability to the depressogenic effects of the stress hormone corticosterone. Stress is an identified risk factor for the onset of depressive symptoms, but depression also has a significant genetic component, suggesting that environmental factors and genetic background likely interact in the etiology of depression. Previous results have revealed that reelin levels are decreased in post-mortem hippocampal tissue from patients with schizophrenia, bipolar disorder and depression, and also in an animal model of depression...
June 2011: Neuropharmacology
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