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https://www.readbyqxmd.com/read/28549345/a-novel-synthetic-derivative-of-quercetin-8-trifluoromethyl-3-5-7-3-4-o-pentamethyl-quercetin-inhibits-bladder-cancer-growth-by-targeting-the-ampk-mtor-signaling-pathway
#1
Ting Tao, Caimei He, Jun Deng, Yanjun Huang, Qiongli Su, Mei Peng, Meiling Yi, Kwame Oteng Darko, Hui Zou, Xiaoping Yang
Quercetin is a naturally existing compound and shows attractive anticancer properties for a variety of solid tumors including glioma, bladder cancer, hepatocellular carcinoma, breast cancer, hematological malignancies and prostate carcinoma. However, these anticancer properties have not been clinically approved due to unclear mechanistic information and its low bioactivity. In our previous study, we elucidated that quercetin activates AMPK pathway which is the major mechanism for its unique anticancer effect in bladder cancer...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549339/typical-and-atypical-presenting-symptoms-of-breast-cancer-and-their-associations-with-diagnostic-intervals-evidence-from-a-national-audit-of-cancer-diagnosis
#2
Minjoung Monica Koo, Christian von Wagner, Gary A Abel, Sean McPhail, Greg P Rubin, Georgios Lyratzopoulos
INTRODUCTION: Most symptomatic women with breast cancer have relatively short diagnostic intervals but a substantial minority experience prolonged journeys to diagnosis. Atypical presentations (with symptoms other than breast lump) may be responsible. METHODS: We examined the presenting symptoms of breast cancer in women using data from a national audit initiative (n=2316). Symptoms were categorised topographically. We investigated variation in the length of the patient interval (time from symptom onset to presentation) and the primary care interval (time from presentation to specialist referral) across symptom groups using descriptive analyses and quantile regression...
May 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28548864/oral-administration-of-a-medium-containing-both-d-aspartate-producing-live-bacteria-and-d-aspartate-reduces-rectal-temperature-in-chickens
#3
P H Do, P V Tran, M A Bahry, H Yang, G Han, A Tsuchiya, Y Asami, M Furuse, V S Chowdhury
1. The aim of this study was to investigate the effects on the rectal temperature of young chickens of the oral administration of a medium that contained both live bacteria that produce D-aspartate (D-Asp) and D-Asp. 2. In Experiment 1, chickens were subjected to chronic oral administration of either the medium (containing live bacteria and 2.46 μmol D-Asp) or water from 7 to 14 d of age. Plasma-free amino acids as well as mitochondrial biogenic gene expression in the breast muscle were analysed. In Experiment 2, 7-d-old chickens were subjected to acute oral administration of the above medium or of an equimolar amount of D-Asp to examine their effect on changes in rectal temperature...
May 26, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28548468/comparison-of-direct-and-indirect-methods-of-teaching-breast-self-examination-%C3%A2-influence-on-knowledge-and-attitudes-of-iranian-nursing-and-midwifery-personnel
#4
Sara Shahbazi, Mohammad Heidari, Mansour Ghafourifard
Background: Breast cancer is the most common cancer in women. Monthly breast self-examination (BSE) has been presented as one of the best screening methods available. The aim of this study was to compare effects of both direct and indirect methods of teaching of BSE on knowledge and attitudes of nursing and midwifery personnel. Materials and Methods: The present study was performed on 89 nursing and midwifery personnel in Valiasr hospital of Borujen city. Participants were randomly divided into a direct and an indirect training group...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28547837/does-body-image-influence-the-relationship-between-body-weight-and-breastfeeding-maintenance-in-new-mothers
#5
Vivien Swanson, Alice Keely, Fiona C Denison
OBJECTIVES: Obese women have lower breastfeeding initiation and maintenance rates than healthy weight women. Research generally focuses on biomedical explanations for this. Psychosocial factors including body image and well-being after childbirth are less well understood as predictors of breastfeeding. In obese and healthy weight women, we investigated changes in body image between 72 hrs post-delivery and 6-8 weeks post-natal, studying how women's body image related to breastfeeding initiation and maintenance...
May 26, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28546878/effects-of-medicare-coverage-of-a-welcome-to-medicare-visit-on-use-of-preventive-services-among-new-medicare-enrollees
#6
Boon Peng Ng, Gail A Jensen, Heather Fritz
In January 2005, Medicare began covering a one-time initial preventive physical examination (IPPE), also called a "Welcome-to-Medicare" visit, during a beneficiary's first 6 months under Part B. This paper examines the effects of offering Medicare IPPE coverage on the use of mammograms, breast self-exams, Pap smears, prostate cancer screenings, cholesterol screenings, and flu vaccines among beneficiaries new to Part B. We adopt a difference-in-difference estimator and estimate a set of multivariate logit models to quantify the effects of introducing Medicare IPPE coverage on the use of preventive services...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28546702/efficacy-of-sentinel-lymph-node-biopsy-in-detecting-axillary-metastasis-in-breast-cancer-using-methylene-blue
#7
Vipul V Nandu, Milind S Chaudhari
Breast cancer is the leading malignancy and the second leading cause of cancer-related deaths. Axillary lymph node status is a very important prognostic factor in breast cancer patients; nodal evaluation is therefore a critical part of breast cancer management. Axillary lymph node dissection results in significant morbidity. Sentinel lymph node biopsy (SLNB) is being used in many centers to stage the axilla in planning axillary dissection management of patients and hence plays an important part in reducing morbidity among patients with carcinoma breast...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28546059/inflammation-and-attentional-bias-in-breast-cancer-survivors
#8
Chloe C Boyle, Patricia A Ganz, Kathleen M Van Dyk, Julienne E Bower
Evidence suggests an association between inflammation and depression, although findings are mixed. Focusing on core processes in depression may clarify associated biological underpinnings. Negative cognitive bias is a key component of depression, but has not been examined in relation to inflammation. Thus, we tested the hypothesis that elevated inflammatory markers would be associated with negative attentional bias in a sample of 91 breast cancer survivors. Participants were drawn from a larger study and provided blood samples for assessment of peripheral markers of inflammation and completed questionnaires and neuropsychological testing...
May 22, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28545563/additional-value-of-18-f-fdg-pet-ct-response-evaluation-in-axillary-nodes-during-neoadjuvant-therapy-for-triple-negative-and-her2-positive-breast-cancer
#9
Mette S van Ramshorst, Suzana C Teixeira, Bas B Koolen, Kenneth E Pengel, Kenneth G Gilhuijs, Jelle Wesseling, Sjoerd Rodenhuis, Renato A Valdés Olmos, Emiel J Rutgers, Wouter V Vogel, Gabe S Sonke, Marie-Jeanne T Vrancken Peeters
BACKGROUND: (18)F-FDG PET/CT can monitor metabolic activity in early breast cancer during neoadjuvant systemic therapy (NST), but it is unknown if the metabolic breast and axillary response differ. We evaluated the correlation between metabolic breast and axillary response at various time points during NST. Furthermore, we analysed if the combined metabolic response improves pathologic complete response (pCR) prediction compared to using the metabolic breast response alone. METHODS: (18)F-FDG PET/CT was performed at baseline (PET1), 2-3 weeks (PET2), and 6-8 weeks (PET3) of NST in patients with triple-negative (TN) and HER2-positive node-positive breast cancer...
May 25, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28545469/age-related-terminal-duct-lobular-unit-involution-in-benign-tissues-from-chinese-breast-cancer-patients-with-luminal-and-triple-negative-tumors
#10
Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D Figueroa, Mark E Sherman, Gretchen L Gierach, Ning Lu, Xiaohong R Yang
BACKGROUND: Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, researchers have found that age-matched women with lower levels of TDLU involution are at increased risk of developing breast cancer. We previously showed that breast cancer cases with core basal phenotype (CBP; estrogen receptor negative [ER(-)], progesterone receptor-negative [PR(-)], human epidermal growth factor receptor 2-negative [HER2(-)], cytokeratins (CK 5 or CK5/6)-positive [CK5/6(+)] and/or epidermal growth factor receptor-positive [EGFR(+)]) tumors had significantly reduced TDLU involution compared with cases with luminal A (ER(+) and/or PR(+), HER2(-), CK5/6(-), EGFR(-)) tumors from a population-based case-control study in Poland...
May 25, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28545198/assessing-breast-cancer-awareness-in-thai-women-validation-of-the-breast-cancer-awareness-scale-b-cas
#11
Nitchamon Rakkapao, Supannee Promthet, Malcolm Anthony Moore, Solikhah Solikhah, Cameron Hurst
Background: Raising breast cancer awareness is a well-established first line strategy to reduce breast cancer mortality. A properly validated instrument is needed to gain a better understanding of breast cancer awareness. Objective: The objective of this study was to develop and validate an instrument to assess breast cancer awareness in Thai women. Methods: In this study, we develop and evaluate the validity of the Breast Cancer Awareness Scale (B-CAS). Construct validity was evaluated by using exploratory factor analysis and confirmatory factor analysis, and criterion validity was investigated using ROC curves to examine the associations between B-CAS subscales and breast self-examination...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545197/congruence-between-preferred-and-actual-participation-roles-increases-satisfaction-with-treatment-decision-making-among-japanese-women-with-breast-cancer
#12
Keiko Yamauchi, Motoyuki Nakao, Mitsuyo Nakashima, Yoko Ishihara
Objective: This study investigated the correlation between participation in the treatment decision-making process and satisfaction with the process among Japanese women with breast cancer. The influence of sociodemographic and clinical characteristics on satisfaction with the treatment decision-making process was also examined. Methods: We conducted a cross-sectional, self-administered internet survey of 650 Japanese women with breast cancer in March 2016. Decisional role (active, collaborative, passive) in the treatment decision-making was elicited using the Japanese version of the Control Preference Scale...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545194/knowledge-attitudes-and-preventive-practice-towards-breast-cancer-among-general-practitioner-health-professionals-in-morocco
#13
Naima Abda, Adil Najdi, Samira El Fakir, Nabil Tachfouti, Mohamed Berraho, Youssef Chami Khazraji, Loubna Abousselham, Latifa Belakhel, Rachid Bekkali, Chakib Nejjari
Background: Breast cancer is the most common cancer of women in Morocco and its diagnosis is usually made at advanced stages. The aim of this study was to describe the knowledge, practices and attitudes of general practitioners regarding early detection of breast cancer. Methods: A cross-sectional study was carried out during July 2011 on a sample of 140 general practitioners employed in basic health care facilities. Results: The majority (85.7%) of general practitioners were aware of the existence of a ministerial circular which aimed to generalize breast cancer screening...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545182/breast-cancer-in-australian-indigenous-women-incidence-mortality-and-risk-factors
#14
Kriscia A Tapia, Gail Garvey, Mark Mc Entee, Mary Rickard, Patrick Brennan
The Indigenous people of Australia face significant health gaps compared with the general population, with lower life expectancies, higher rates of death, and chronic illness occurring more often than in non-indigenous Australians. Cancer is the second largest contributor to the burden of disease with breast cancer being the most common invasive cancer diagnosed for females. Despite a lower breast cancer incidence compared with non-indigenous women, fatalities occur at an elevated rate and breast cancers have an earlier age of onset...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545063/financial-distress-in-patients-with-advanced-cancer
#15
Cécile Barbaret, Christelle Brosse, Wadih Rhondali, Murielle Ruer, Léa Monsarrat, Patrick Michaud, Anne Marie Schott, Marvin Delgado-Guay, Eduardo Bruera, Stéphane Sanchez, Marilène Filbet
PURPOSE: We examined the frequency and severity of financial distress (FD) and its association with quality of life (QOL) and symptoms among patients with advanced cancer in France. DESIGN: In this cross-sectional study, 143 patients with advanced cancer were enrolled. QOL was assessed using the Functional Assessment of Cancer General (FACT-G) and symptoms assessed using Edmonton Assessment System (ESAS) and Hospital Anxiety and Depression Scale (HADS). FD was assessed using a self-rated numeric scale from 0 to 10...
2017: PloS One
https://www.readbyqxmd.com/read/28544964/biophysical-and-biological-studies-of-some-polymer-grafted-metallo-intercalators
#16
Yesaiyan Manojkumar, Subramanian Ambika, Rajendran Senthilkumar, Sankaralingam Arunachalam
Two water-soluble polymer-copper(II) complexes, [Cu(ip)2(BPEI)](ClO4)2·H2O (Complex 1) and [Cu(dppz)2BPEI](ClO4)2·H2O (Complex 2) with different degree of coordination have been synthesized and characterized. The interaction between the prepared complexes and CTDNA has been assessed by various physico-chemical methods The spectroscopic and the cyclic voltammetry studies have revealed that both the complexes interact with CTDNA through intercalation binding mode. Among the two complexes, Complex 2 has higher binding affinity with CTDNA...
May 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544436/losing-the-breast-a-meta-synthesis-of-the-impact-in-women-breast-cancer-survivors
#17
REVIEW
Lingshan Sun, Emily Ang, Wei How Daryl Ang, Violeta Lopez
OBJECTIVES: To summarize qualitative studies exploring the impact of losing the breast in women breast cancer survivors. METHODS: We identify, appraise and synthesise 12 qualitative studies from 2000 to 2015. Quality appraisal of the studies was examined using the Critical Appraisal Skill Programme Checklist and Sandelowski and Barroso's step to synthesise the findings. RESULTS: The age of women in these studies ranged from 30-77 years. Losing the breast was regarded as disfigurement resulting in a discrepancy between self and societal image of a woman...
May 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28542870/the-breast-and-cervical-cancer-early-detection-program-medicaid-and-breast-cancer-outcomes-among-ohio-s-underserved-women
#18
Siran M Koroukian, Paul M Bakaki, Phyo Than Htoo, Xiaozhen Han, Mark Schluchter, Cynthia Owusu, Gregory S Cooper, Johnie Rose, Susan A Flocke
BACKGROUND: As an organized screening program, the national Breast and Cervical Cancer Early Detection Program (BCCEDP) was launched in the early 1990s to improve breast cancer outcomes among underserved women. To analyze the impact of the BCCEDP on breast cancer outcomes in Ohio, this study compared cancer stages and mortality across BCCEDP participants, Medicaid beneficiaries, and "all others." METHODS: This study linked data across the Ohio Cancer Incidence Surveillance System, Medicaid, the BCCEDP database, death certificates, and the US Census and identified 26,426 women aged 40 to 64 years who had been diagnosed with incident invasive breast cancer during the years 2002-2008 (deaths through 2010)...
May 23, 2017: Cancer
https://www.readbyqxmd.com/read/28542677/association-of-previous-clinical-breast-examination-with-reduced-delays-and-earlier-stage-breast-cancer-diagnosis-among-women-in-peru
#19
Anya Romanoff, Tara Hayes Constant, Kay M Johnson, Manuel Cedano Guadiamos, Ana María Burga Vega, Joseph Zunt, Benjamin O Anderson
Importance: Mammographic screening is impractical in most of the world where breast cancers are first identified based on clinical signs and symptoms. Clinical breast examination may improve early diagnosis directly by finding breast cancers at earlier stages or indirectly by heightening women's awareness of breast health concerns. Objective: To investigate factors that influence time to presentation and stage at diagnosis among patients with breast cancer to determine whether history of previous clinical breast examination is associated with earlier presentation and/or earlier cancer stage at diagnosis...
May 25, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28542075/examining-the-role-of-antimicrobial-irrigation-and-capsular-contracture-a-systematic-review-and-meta-analysis
#20
James J Drinane, Tayseer Chowdhry, Thuy-Huong Pham, Edmond Ritter
PURPOSE: The purpose of this study was to conduct a meta-analysis to determine if irrigation of breast implant pockets with antibiotics reduces the rate of capsular contracture (CC). Capsular contracture is the most common complication after primary augmentation mammoplasty, yet its etiology remains cryptogenic. METHODS: PubMed was searched for publications from January 1 of 2000 through October of 2015. Studies with the following criteria were included: primary breast augmentation with implants, use of antimicrobial irrigation (AMI), and documentation of CC...
May 24, 2017: Annals of Plastic Surgery
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