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https://www.readbyqxmd.com/read/29694674/local-anaesthetics-and-regional-anaesthesia-versus-conventional-analgesia-for-preventing-persistent-postoperative-pain-in-adults-and-children
#1
REVIEW
Erica J Weinstein, Jacob L Levene, Marc S Cohen, Doerthe A Andreae, Jerry Y Chao, Matthew Johnson, Charles B Hall, Michael H Andreae
BACKGROUND: Regional anaesthesia may reduce the rate of persistent postoperative pain (PPP), a frequent and debilitating condition. This review was originally published in 2012 and updated in 2017. OBJECTIVES: To compare local anaesthetics and regional anaesthesia versus conventional analgesia for the prevention of PPP beyond three months in adults and children undergoing elective surgery. SEARCH METHODS: We searched CENTRAL, MEDLINE, and Embase to December 2016 without any language restriction...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29694631/humoral-hypercalcemia-of-pregnancy-treated-with-bisphosphonates
#2
Ronit Koren, Ortal Neeman, Shlomit Koren, Carlos A Benbassat
Hypercalcemia can be hazardous during pregnancy, most cases being due to primary hyperparathyroidism. We report a case of hypercalcemia with suppressed PTH levels necessitating treatment with bisphosphonates during pregnancy. A 38-year-old woman at the 26th week gestation was admitted because of symptomatic hypercalcemia. She did not take any medication that could influence her calcium levels. Physical examination was unremarkable. Laboratory tests on admission were: calcium 12.7 mg/dL (8.5-10.5 mg/dL), phosphorus 1...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29694313/paget-s-disease-of-the-male-breast-case-report-and-a-point-of-view-from-actual-literature
#3
M Vergine, A Musella, E Gulotta, F Frusone, Alberto De Luca, F Maceli, A Libia, P Benedetti Panici, M Monti
INTRODUCTION: Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget's disease could hide an invasive ductal breast cancer. CASE DESCRIPTION: We report the case of a 77-years old man affected by Alzheimer's disease, who presented to our attention because of an ulcerated palpable mass in the right nipple. A biopsy of the lesion showed "intra-epidermic proliferation of epitelioid cells, associated with linfo-plasmacellular infiltration of superficial dermis, compatible with Paget's disease (pTis)"...
March 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29693976/evaluation-of-osteopontin-as-a-biomarker-in-hepatocellular-carcinomas-in-egyptian-patients-with-chronic-hcv-cirrhosis
#4
Samah Mamdouh Abdel-Hafiz, Hussam EM Hamdy, Fatma M Khorshed, Tarek S Aboushousha, Gehan Safwat, Mohamed A Saber, Mohamed Seleem, Amira H Soliman
Background: Hepatocellular carcinoma (HCC) is a high incidence disease in Egypt with a poor prognosis and survival. Biomarkers are important for diagnosis of HCC at an early stage. Osteopontin (OPN), a glycoprotein secreted by macrophages, osteoblasts, and T cells, is also highly expressed in a variety of tumors, such as examples in the breast, colon, and stomach. The present study aimed to correlate the serum level of OPN in HCV-positive hepatocellular carcinoma patients, with OPN expression in tumor and non-tumor liver tissues in order to identify its efficacy as a biomarker for diagnosis...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29693343/detection-of-a-4-bp-insertion-deletion-polymorphism-within-the-promoter-of-egln2-using-mismatch-pcr-rflp-and-its-association-with-susceptibility-to-breast-cancer
#5
Mohammad Hashemi, Hiva Danesh, Fatemeh Bizhani, Hedieh Sattarifard, Seyed Mehdi Hashemi, Gholamreza Bahari
It has been shown that a 4-bp insertion/deletion (ins/del) polymorphism of EGLN2 influences the risk of several cancers. However, to date, no study has inspected the impact of the 4-bp ins/del polymorphism on breast cancer (BC) risk. A case-control study, including 134 breast cancer patients and 154 healthy women, was here conducted to examine the possible association between EGLN2 4-bp ins/del polymorphism and BC risk in a southeast Iranian population. A mismatched polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was designed for genotyping of the variant...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29693231/lnc-rna-h19-is-associated-with-poor-prognosis-in-breast-cancer-patients-and-promotes-cancer-stemness
#6
Hidetaka Shima, Kumiko Kida, Shoko Adachi, Akimitsu Yamada, Sadatoshi Sugae, Kazutaka Narui, Yohei Miyagi, Mayuko Nishi, Akihide Ryo, Soichiro Murata, Hideki Taniguchi, Yasushi Ichikawa, Takashi Ishikawa, Itaru Endo
PURPOSE: Aldehyde dehydrogenase1 (ALDH1) is widely accepted as a stem cell marker for normal breast as well as in breast cancer. Although the clinical impact of ALDH1 was observed in our previous study, we do not know how ALDH1 affects stem cell features resulting in worsening of prognosis in breast cancer. The purpose of this study is to explore ALDH1-related gene and its function on cancer stem cell (CSC). METHODS: In five cases of ALDH1-positive triple-negative breast cancer, mRNA expression profile was compared between ALDH1-positive and ALDH1-negative cells by Affymetrix microarray analysis after microdissection...
April 24, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29693229/physician-peer-group-characteristics-and-timeliness-of-breast-cancer-surgery
#7
Jacqueline Bachand, Pamela R Soulos, Jeph Herrin, Craig E Pollack, Xiao Xu, Xiaomei Ma, Cary P Gross
PURPOSE: Little is known about how the structure of interdisciplinary groups of physicians affects the timeliness of breast cancer surgery their patients receive. We used social network methods to examine variation in surgical delay across physician peer groups and the association of this delay with group characteristics. METHODS: We used linked Surveillance, Epidemiology, and End Results-Medicare data to construct physician peer groups based on shared breast cancer patients...
April 24, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29693228/response-rates-and-pathologic-complete-response-by-breast-cancer-molecular-subtype-following-neoadjuvant-chemotherapy
#8
Waqar Haque, Vivek Verma, Sandra Hatch, V Suzanne Klimberg, E Brian Butler, Bin S Teh
PURPOSE: This is the largest study to date evaluating response rates and pathologic complete response (pCR) and predictors thereof, based on molecular subtype, in women with breast cancer having undergone neoadjuvant chemotherapy (NC). METHODS: The National Cancer Database was queried for women with cT1-4N1-3M0 breast cancer having received NC. Patients were divided into four subtypes: luminal A, luminal B, Her2, or triple negative (TN). Multivariable logistic regression ascertained factors associated with developing pCR...
April 24, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29693227/the-relationship-between-tumour-size-nodal-status-and-distant-metastases-on-the-origins-of-breast-cancer
#9
Victoria Sopik, Steven A Narod
BACKGROUND: In patients with breast cancer, increasing tumour size at diagnosis is associated with an increased likelihood of axillary lymph node involvement and increased breast cancer-specific mortality. However, this relation is based on studies which combine all tumours smaller than 1.0 cm in a single category and all tumours larger than 5.0 cm in another category. This coarse classification may obscure a nuanced description of the effects of tumour size across the full range of possible sizes...
April 24, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29693203/online-information-and-support-needs-of-women-with-advanced-breast-cancer-a-qualitative-analysis
#10
Emma Kemp, Bogda Koczwara, Phyllis Butow, Jane Turner, Afaf Girgis, Penelope Schofield, Nicholas Hulbert-Williams, Janelle Levesque, Danielle Spence, Sina Vatandoust, Ganessan Kichenadasse, Amitesh Roy, Shawgi Sukumaran, Christos S Karapetis, Caroline Richards, Michael Fitzgerald, Lisa Beatty
PURPOSE: Women with advanced breast cancer (ABC) face significant adjustment challenges, yet few resources provide them with information and support, and attendance barriers can preclude access to face-to-face psychosocial support. This paper reports on two qualitative studies examining (i) whether information and support-seeking preferences of women with ABC could be addressed in an online intervention, and (ii) how an existing intervention for patients with early stage cancer could be adapted for women with ABC...
April 24, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29693154/emodin-inhibits-epithelial%C3%A2-mesenchymal-transition-and-metastasis-of-triple-negative-breast-cancer-via-antagonism-of-cc%C3%A2-chemokine-ligand-5-secreted-from-adipocytes
#11
Xiaoyun Song, Xiqiu Zhou, Yuenong Qin, Jianfeng Yang, Yu Wang, Zhenping Sun, Kui Yu, Shuai Zhang, Sheng Liu
Triple negative breast cancer (TNBC) has the lowest survival rate of the breast cancer subtypes owing to its aggressive and metastatic behavior. It has been reported that peritumoral adipose tissue contributes to the cell invasiveness and dissemination of TNBC. Emodin is an active anthraquinone derivative isolated from Rheum palmatum, with anticancer properties that have been reported to inhibit lung metastasis in a nude mouse xenograft model. In the present study, the effects of emodin on human TNBC cells and adipocytes were investigated in vivo and in vitro...
April 23, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29692735/mequindox-induced-genotoxicity-and-carcinogenicity-in-mice
#12
Qianying Liu, Zhixin Lei, Qin Wu, Deyu Huang, Shuyu Xie, Xu Wang, Yuanhu Pan, Zonghui Yuan
Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N -oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for one and a half years. The result showed adverse effects on body weights, feed consumption, hematology, serum chemistry, organ weights, relative organ weights, and incidence of tumors during most of the study period. Treatment-related changes in hematology, serum chemistry, relative weights and histopathological examinations revealed that the hematological system, liver, kidneys, and adrenal glands, as well as the developmental and reproductive system, were the main targets after MEQ administration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29692460/primary-mucinous-adenocarcinoma-of-skin-myoepithelial-cells-are-a-clue-to-its-diagnosis
#13
Radha Sistla, Tameem Afroz, Jithendran Narayanswamy
Primary mucinous adenocarcinoma is a rare adnexal neoplasm of eccrine gland. Fewer than 200 cases are reported in literature. Clinically, it can be mistaken as a benign lesion. The primary challenge in these lesions is to differentiate these rare primary lesions from more frequent mucinous secondary deposits. Morphologically, they are similar to metastatic deposits of mucinous carcinoma from other viscera such as breast, lung, or gastrointestinal tract. Use of ancillary techniques and a thorough metastatic work up are mandatory to differentiate these lesions from metastases...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29691980/glucocorticoids-modulate-multidrug-resistance-transporters-in-the-first-trimester-human-placenta
#14
Phetcharawan Lye, Enrrico Bloise, Lubna Nadeem, William Gibb, Stephen J Lye, Stephen G Matthews
The placental multidrug transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP, ABCG2) protect the foetus from exposure to maternally derived glucocorticoids, toxins and xenobiotics. During pregnancy, maternal glucocorticoid levels can be elevated by stress or exogenous administration. We hypothesized that glucocorticoids modulate the expression of ABCB1/P-gp and ABCG2/BCRP in the first trimester human placenta. Our objective was to examine whether dexamethasone (DEX) or cortisol modulate first trimester placental expression of multidrug transporters and determine whether cytotrophoblasts or the syncytiotrophoblast are/is responsible for mediating these effects...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29691364/primary-care-colorectal-cancer-screening-correlates-with-breast-cancer-screening-implications-for-colorectal-cancer-screening-improvement-interventions
#15
Jennifer M Weiss, Nancy Pandhi, Sally Kraft, Aaron Potvien, Pascale Carayon, Maureen A Smith
OBJECTIVE: National colorectal cancer (CRC) screening rates have plateaued. To optimize interventions targeting those unscreened, a better understanding is needed of how this preventive service fits in with multiple preventive and chronic care needs managed by primary care providers (PCPs). This study examines whether PCP practices of other preventive and chronic care needs correlate with CRC screening. METHODS: We performed a retrospective cohort study of 90 PCPs and 33,137 CRC screening-eligible patients...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691360/radiation-dose-in-breast-imaging
#16
Teresa G Odle
Screening mammography introduces low doses of radiation per examination and in regular intervals over decades for women who have annual screening. Further, advanced breast imaging modalities and follow-up imaging methods contribute to additional radiation exposure in radiosensitive breast tissue. This article reviews the effects of radiation on the breasts, summarizes dose measurements and estimates for breast imaging modalities, and discusses efforts to optimize dose in breast imaging.
March 2018: Radiologic Technology
https://www.readbyqxmd.com/read/29691345/evaluating-mammographer-acceptance-of-mammorisk-software
#17
Jean Weigert, Nancy Cavanaugh, Talong Ju
PURPOSE: To evaluate mammographers' acceptance of the breast cancer risk assessment software tool MammoRisk (Statlife) in the clinical setting. METHODS: During a 6-month period, 1200 women undergoing routine mammography examinations at a regional, outpatient, comprehensive breast imaging center were assessed for breast cancer risk by mammographers who used the MammoRisk software. At the end of the 6-month period, the mammographers (N = 11) completed an 8-question survey on their willingness to the use of the software in the clinical setting...
March 2018: Radiologic Technology
https://www.readbyqxmd.com/read/29690887/relational-spirituality-and-quality-of-life-2007-to-2017-an-integrative-research-review
#18
REVIEW
Victor Counted, Adam Possamai, Tanya Meade
BACKGROUND: Despite the increasing number of evidence-based research on relational spirituality (RS) and quality of life (QoL) in medical-health research, little is known about the links between RS and QoL outcomes and the mechanisms by which RS aspects are functionally tied to QoL. OBJECTIVE: To determine how RS is perceived/positioned in relation to QoL, we (a) examined recent available data that identify and appraise the links between RS and QoL; (b) identified themes emerging from the association between RS and QoL, and (c) discussed the implications of the effects of RS on QoL outcomes...
April 24, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29690858/effects-of-menopausal-symptoms-and-depression-on-the-quality-of-life-of-premenopausal-women-with-breast-cancer-in-korea
#19
Jeong Ae Han, So Young Choi, Seonah Lee
INTRODUCTION: As breast cancer survivors have increased, improving quality of life of the survivors becomes an important issue. The purpose of this study was to examine relationships among menopausal symptoms, depression, and quality of life and to identify the factors affecting the quality of life in premenopausal women with breast cancer. METHOD: This was a descriptive, correlational study using structured questionnaires for 90 premenopausal women with breast cancer attending the outpatient clinic of a tertiary hospital in Korea...
April 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29687878/anthracycline-and-trastuzumab-induced-cardiotoxicity-in-breast-cancer
#20
M A Nicolazzi, A Carnicelli, M Fuorlo, A Scaldaferri, R Masetti, R Landolfi, A M R Favuzzi
OBJECTIVE: Breast cancer is the most common cancer among women. In the last twenty years early diagnosis, neoadjuvant and adjuvant systemic treatment that targeted to specific molecular targets have significantly reduced the mortality from breast cancer. However, the increase in survival has allowed to observe the cardiotoxic effects of anticancer therapy and increased mortality from cardiovascular causes, resulting in a large literature where experts try to identify the correct management of this critical problem...
April 2018: European Review for Medical and Pharmacological Sciences
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