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https://www.readbyqxmd.com/read/29907919/discontinuation-of-hormone-therapy-for-elderly-breast-cancer-patients-after-hypofractionated-whole-breast-radiotherapy
#1
Michela Dispinzieri, Eliana La Rocca, Elisabetta Meneghini, Alba Fiorentino, Laura Lozza, Serena Di Cosimo, Massimiliano Gennaro, Vito Cosentino, Milena Sant, Emanuele Pignoli, Riccardo Valdagni, Francesca Bonfantini, Maria Carmen De Santis
The purpose of the study was to examine adherence to hormone therapy (HT) in elderly breast cancer patients (≥ 65 years old) treated with hypofractionated radiotherapy. We analyzed data on 550 ER-positive breast cancer patients given hypofractionated whole-breast radiotherapy from June 2009 to September 2016. Baseline comorbidities considered in the hypertension-augmented Charlson Comorbidity Index (hCCI) were retrospectively retrieved. Total hCCI scores were classified as no comorbidity (hCCI = 0), low burden of comorbidity (hCCI = 1), and high burden of comorbidity (hCCI ≥ 2)...
June 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29907750/examining-the-associations-among-fibrocystic-breast-change-total-lean-mass-and-percent-body-fat
#2
Yuan-Yuei Chen, Wen-Hui Fang, Chung-Ching Wang, Tung-Wei Kao, Yaw-Wen Chang, Hui-Fang Yang, Chen-Jung Wu, Yu-Shan Sun, Wei-Liang Chen
Fibrocystic breast change (FBC) is extremely common and occurrs in 90% of women during their lives. The association between body composition and risk of breast cancer is well established. We hypothesized that the effect might exist during the development of FBC. Our aim was to examine the relationships of total lean mass (TLM) and percent body fat (PBF) with FBC in a general female population. In total, 8477 female subjects aged 20 years or older were enrolled in the study at the Tri-Service General Hospital in Taiwan from 2011 to 2016...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907260/usefulness-of-the-twinkling-artifact-on-doppler-ultrasound-for-the-detection-of-breast-microcalcifications
#3
A Relea, J A Alonso, M González, C Zornoza, S Bahamonde, B E Viñuela, M B Encinas
OBJECTIVE: To determine whether the twinkling artifact on Doppler ultrasound imaging corresponds to microcalcifications previously seen on mammograms and to evaluate the usefulness of this finding in the ultrasound management of suspicious microcalcifications. MATERIAL AND METHODS: We used ultrasonography to prospectively examine 46 consecutive patients with groups of microcalcifications suspicious for malignancy identified at mammography, searching for the presence of the twinkling artifact to identify the microcalcifications...
June 12, 2018: Radiología
https://www.readbyqxmd.com/read/29906747/anti-tumor-and-anti-metastasis-activities-of-honey-bee-larvae-powder-by-suppressing-the-expression-of-ezh2
#4
Masakatsu Kageyama, Kejuan Li, Shuang Sun, Guoqing Xing, Ran Gao, Zhongfang Lei, Zhenya Zhang
Honey bee larvae products have been widely used as traditional daily supplements and complementary medicine for health promotion. However, there is little scientific evidence about their bioactivities. This study was designed to examine the anti-tumor and anti-metastasis effects of honey bee larvae powder (HLP) and explore the underlying mechanism. A subcutaneous transplantation model (murine breast cancer cell 4T1-LUC) and lung metastasis model (murine melanoma cell B16-F10) were established to evaluate the anti-tumor and anti-metastasis effects of HLP...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906404/collagen-1a1-col1a1-promotes-metastasis-of-breast-cancer-and-is-a-potential-therapeutic-target
#5
Jing Liu, Jia-Xin Shen, Hua-Tao Wu, Xiao-Li Li, Xiao-Fen Wen, Cai-Wen Du, Guo-Jun Zhang
PURPOSE: Extracellular matrix (ECM) is an important component of tumor microenvironment and plays critical roles in cancer development and metastasis, in which collagen is the major structural protein. Collagen type I alpha 1 (COL1A1) is reportedly associated with the development of several human diseases. However, the functions and mechanisms of cellular expression of COL1A1 in breast cancer remain unknown. The purpose of this study is to investigate the cellular expression of COL1A1 in breast cancer cells and patients, and its role in the development and metastasis of breast cancer...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29906273/breast-cancer-risk-markedly-lower-with-serum-25-hydroxyvitamin-d-concentrations-%C3%A2-60-vs-20-ng-ml-150-vs-50-nmol-l-pooled-analysis-of-two-randomized-trials-and-a-prospective-cohort
#6
Sharon L McDonnell, Carole A Baggerly, Christine B French, Leo L Baggerly, Cedric F Garland, Edward D Gorham, Bruce W Hollis, Donald L Trump, Joan M Lappe
BACKGROUND: While numerous epidemiologic studies have found an association between higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower breast cancer risk, few have assessed this association for concentrations >40 ng/ml. OBJECTIVE: To investigate the relationship between 25(OH)D concentration and breast cancer risk across a broad range of 25(OH)D concentrations among women aged 55 years and older. METHODS: Analyses used pooled data from two randomized clinical trials (N = 1129, N = 2196) and a prospective cohort (N = 1713) to examine a broad range of 25(OH)D concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29905920/breast-cancer-risk-evaluation-by-utilizing-gail-model-and-association-between-breast-cancer-risk-perception-with-early-diagnosis-applications-among-midwives-and-nurses-working-in-primary-health-services
#7
Ebru Turhan, Gokben Yasli
OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905475/differential-effects-of-quercetin-and-its-two-derivatives-isorhamnetin-and-isorhamnetin-3-glucuronide-in-inhibiting-proliferation-of-human-breast-cancer-mcf-7-cells
#8
Qiu Wu, Paul A Kroon, Hongjun Shao, Paul W Needs, Xingbin Yang
Quercetin (Que) has consistently been reported to be useful cytotoxic compound in vivo and in vitro, but little is known on its metabolites. Here we examined and compared cytotoxic effect of Que and its water-soluble metabolites, isorhamnetin (IS) and isorhamnetin-3-glucuronide (I3G) in human breast cancer MCF-7 cells, and explain their tumor-inhibitory mechanism and structure-function relationship. The results showed that Que, IS and I3G could dose-dependently inhibit the growth of MCF-7 cells, and the cytotoxic effect was ranked as Que > IS > I3G...
June 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29905007/simultaneous-downregulation-of-mir-21-and-mir-155-through-oleuropein-for-breast-cancer-prevention-and-therapy
#9
Maryam Abtin, Mohammad R Alivand, Mahmoud S Khaniani, Milad Bastami, Mohammad Zaeifizadeh, Sima M Derakhshan
Breast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti-neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR-21 and miR-155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904989/psychosocial-mediators-of-dietary-change-among-hispanic-latina-breast-cancer-survivors-in-a-culturally-tailored-dietary-intervention
#10
Zaixing Shi, John M Richardson, A Corina Aycinena, Heewon L Gray, Rachel Paul, Pam Koch, Isobel Contento, Ann Ogden Gaffney, Heather Greenlee
OBJECTIVE: To examine psychosocial mediators of the effect of a culturally-tailored dietary intervention on dietary change among Hispanic/Latina breast cancer survivors. METHODS: Hispanic/Latina breast cancer survivors (n=70) were randomized to receive either a 12-week theory- and culturally-tailored dietary change program (intervention group, n=34), or standard-of-care printed recommendations (control group, n=36) (ClinicalTrials.gov NCT01414062). Fruit/vegetable intake (F/V), % calories from fat, and hypothesized psychosocial mediators were assessed at baseline, 6 and 12-months...
June 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29904980/naturalistically-observing-non-cancer-conversations-among-couples-coping-with-breast-cancer
#11
Megan L Robbins, Alexander Karan, Ana Maria Lopez, Karen Weihs
OBJECTIVE: This study revealed the landscape of non-cancer conversations, identifying topics and types of everyday conversation, and examined links to psychological adjustment among couples coping with breast cancer. METHODS: Fifty-two couples wore the Electronically Activated Recorder (EAR) over one weekend and self-reported psychological adjustment while patients were on treatment. The EAR sampled 50 s of ambient sound every 9 min to estimate the frequency of non-cancer conversation and reveal topics and types of conversation...
June 14, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29904731/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-3-hispanic-american-patients
#12
Shearwood McClelland, Carmen A Perez
Purpose: Health disparities have profoundly affected underrepresented minorities throughout the United States, particularly with regard to access to evidence-based interventions such as surgery or medication. The degree of disparity in access to radiation therapy (RT) for Hispanic-American patients with cancer has not been previously examined in an extensive manner. Methods and materials: An extensive literature search was performed using the PubMed database to examine studies investigating disparities in RT access for Hispanic-Americans...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904605/women-s-recall-of-maternal-and-newborn-interventions-received-in-the-postnatal-period-a-validity-study-in-kenya-and-swaziland
#13
Katharine J McCarthy, Ann K Blanc, Charlotte E Warren, Brian Mdawida
Background: Despite the concentration of maternal and infant deaths in the early postnatal period, information on the content and quality of postnatal care interventions is not routinely collected in most low and middle-income countries. At present, data on the coverage of postnatal care interventions mostly rely on women's reports collected in household surveys, such as the Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS), which collect limited information...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29904116/neutrophil-tlr4-and-pkr-are-targets-of-breast-cancer-cell-glycosaminoglycans-and-effectors-of-glycosaminoglycan-induced-april-secretion
#14
Uilst Bat-Erdene, Eric Quan, Kelvin Chan, Brianna-Marie Lee, Wejdan Matook, Ki-Young Lee, Jesusa L Rosales
A proliferation-inducing ligand (APRIL), which induces survival and migration signals and tumor growth, is commonly observed in breast cancer tissues but is not often expressed in breast cancer cells themselves. Here, we examined whether breast cancer cells induce APRIL secretion from neutrophils, which are frequently recruited into the breast tumor microenvironment. We found that breast cancer cells do stimulate neutrophils to secrete APRIL through their glycosaminoglycans. Breast cancer cells depleted of heparan sulfate or chondroitin sulfate glycosaminoglycans lose their ability to induce APRIL secretion from neutrophils, and heparan sulfate and chondroitin sulfate can induce secretion that is comparable to that of breast cancer cell-induced secretion...
June 15, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29903175/-prevalence-of-metabolic-syndrome-and-its-family-factors-for-children-and-adolescents-in-chongqing-city-in-2014
#15
Xuting Cheng, Hong Wang, Baocheng Yuan, Peiyu Guan, Lingyi Wang
OBJECTIVE: To study the prevalence and family factors on metabolic syndrome( MS) in children and adolescents for Chongqing City. METHODS: Multi-stage cluster sampling was used to recruit 1309 children and adolescents between 10 and 17 years old for physical examination( height, weight, waist circumference and blood pressure), blood biochemical examination( fasting plasma glucose, triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol)and questionnaire for family factors( breast feeding, delivery mode, birth weight, education of parents, height and weight of parents, family history of hypertension and diabetes, and so on)...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903054/ultrasound-triggered-drug-delivery-for-breast-tumor-therapy-through-irgd-targeted-paclitaxel-loaded-liposome-microbubble-complexes
#16
Jing Zhang, Song Wang, Zhiting Deng, Li Li, Guanghong Tan, Xin Liu, Hairong Zheng, Fei Yan
Liposome-microbubble complexes (LMC) have become a promising therapeutic carrier for ultrasound-triggered local drug release. However, it is still desirable for the released drugs to be delivered to tumors as effectively as possible. Here, we fabricated iRGD-targeted paclitaxel-loaded liposome-microbubble complexes (iRGD-PTX-LMC) and investigated the feasibility of enhancing the local drug delivery to breast tumors by using these complexes along with ultrasound irradiation. Our results showed that iRGD-modified PTX-loaded liposomes (iRGD-PTX-PL) were successfully conjugated to the surface of microbubbles (MBs) through biotin-avidin linkage...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29902579/androgen-receptor-expression-is-a-favorable-prognostic-factor-in-triple-negative-breast-cancers
#17
Tao Zuo, Parker Wilson, Ali Fuat Cicek, Malini Harigopal
Androgen receptor (AR) expression is an emerging prognostic marker that has been observed in 25% to 75% of triple negative breast cancers (TNBCs) that lack estrogen receptor, progesterone receptor and HER2 overexpression. TNBCs are treated with AR-targeted therapies and standardized evaluation of AR expression may help guide patient management. Basal-like TNBCs are a subgroup of TNBCs defined by positive immunoreactivity for CK5/6 or EGFR that carry a worse prognosis. However, it's unclear whether basal-like TNBCs have a different rate of AR positivity or if AR expression is predictive of disease free survival in this patient group...
June 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/29902299/association-of-t-cell-receptor-repertoire-use-with-response-to-combined-trastuzumab-lapatinib-treatment-of-her2-positive-breast-cancer-secondary-analysis-of-the-neoaltto-randomized-clinical-trial
#18
Ryan L Powles, David Redmond, Christos Sotiriou, Sherene Loi, Debora Fumagalli, Paolo Nuciforo, Nadia Harbeck, Evandro de Azambuja, Severine Sarp, Serena Di Cosimo, Jens Huober, Jose Baselga, Martine Piccart-Gebhart, Olivier Elemento, Lajos Pusztai, Christos Hatzis
Importance: Dual anti-HER2 blockade increased the rate of pathologic complete response (pCR) in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALTTO) trial, and high immune gene expression was associated with pCR in all treatment arms. So far, no marker has been identified that is specifically associated with the benefit from dual HER2 blockade. Objective: To examine if use of the T-cell β chain variable genes adds to the potential association of immune gene signatures with response to dual HER2 blockade...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29901782/bariatric-surgery-does-not-appear-to-affect-women-s-breast-milk-composition
#19
Goele Jans, Roland Devlieger, Vicky De Preter, Lieveke Ameye, Kristien Roelens, Matthias Lannoo, Bart Van der Schueren, Johan Verhaeghe, Christophe Matthys
Background: The breast-milk composition in the first 6 wk postpartum of women who have undergone bariatric surgery (BS) is unknown. Objective: The aim of this study was to examine 1) the breast-milk macronutrient and vitamin A composition in women who had and who had not undergone BS and 2) the impact of maternal diet on the breast-milk composition. We hypothesized that the milk of women who had undergone BS would be less energy dense and have a lower vitamin A concentration than that of other women...
June 13, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29901696/rna-interference-targeting-cd147-inhibits-metastasis-and-invasion-of-human-breast-cancer-mcf-7-cells-by-downregulating-mmp-9-vegf-expression
#20
Fang Li, Junping Zhang, Jiqiang Guo, Yuan Jia, Yaping Han, Zhuanhua Wang
Breast cancer is one of the most common malignancies. It is necessary to identify new markers for predicting tumor progression and therapeutic molecular targets. It has been reported that CD147 is one of the most commonly expressed proteins in primary tumors and in metastatic cells. In this study, we investigated the role of CD147 in human breast cancer metastasis and invasion, and examined its underlying molecular mechanisms. Immunohistochemistry results revealed high expression of CD147 in human breast tumor tissues, which was positively correlated with the malignancy of breast cancer...
June 12, 2018: Acta Biochimica et Biophysica Sinica
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