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antibiotic economics

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https://www.readbyqxmd.com/read/28737469/social-and-economic-burden-of-recurrent-urinary-tract-infections-and-quality-of-life-a-patient-web-based-study-gesprit
#1
F Wagenlehner, B Wullt, S Ballarini, D Zingg, K G Naber
Background Uncomplicated lower urinary tract infections (UTIs) occur in approximately 50% of women, and 20-30% experience recurrent UTI. Data on UTIs and quality of life (QoL) in Europe are limited. Methods This was an anonymous, self-administered web-based survey conducted in 5 countries (Germany, Switzerland, Poland, Russia and Italy), on adult women who had experienced recurrent UTI and were affected by acute UTI currently or within 4 weeks of study entry. Questions covered disease course; management; social and economic burden; education, income, and health insurance status...
July 24, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28737025/-influence-of-initial-protocolized-treatment-with-steroids-in-length-of-stay-and-costs-of-community-acquired-pneumonia
#2
J Gómez Gómez, J L Gómez Torres, A Hernández Torres, J A García Córdoba, M Canteras Jordana
OBJECTIVE: The aim of the study was to analyze the impact of steroid treatment in patients with community acquired pneumonia (CAP), both in length of stay and economical cost of admission at a clinical university hospital. METHODS: Prospective study of admitted patients with the diagnosis of CAP, both in Internal Medicine and Infectious diseases department. The study was conducted from January to march 2015; patients receiving steroids from diagnosis to end of antibiotic treatment were classified as group I; otherwise, they were considered in group II...
July 24, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28734738/evaluation-of-the-biotechnological-potential-of-bacterioplankton-from-niter%C3%A3-i-coast-rj
#3
Marcelly Miranda Aybal Jayme, Rebeca Oliveira Castro, Carlos André Mandarino Silva, Mariana Muniz Silva, Flávia Lima do Carmo, Fábio Vieira de Araujo
Production of antibiotics and enzymes by microorganisms is well recognized for its economic benefits. Searching potentially exploitable microorganisms, strains of heterotrophic bacteria were isolated from marine and estuarine waters in Niterói-RJ, Brazil, and tested for the production of enzymes and antimicrobial substances. From the 76 isolated colonies, 09.21% showed antimicrobial potential, 63.16% showed enzymatic activity for at least one of the substrates tested and 91% showed multidrug resistance. Strains that presented the better results were identified by sequencing...
July 19, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28733908/assessment-of-cultivable-oral-bacterial-flora-from-important-venomous-snakes-of-india-and-their-antibiotic-susceptibilities
#4
Innus K Shaikh, Prashant P Dixit, Balasaheb S Pawade, Mugdha Potnis-Lele, Babasaheb P Kurhe
Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities...
July 21, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28722231/bacteria-antibiotic-resistance-new-challenges-and-opportunities-for-implant-associated-orthopaedic-infections
#5
Bingyun Li, Thomas J Webster
There has been a dramatic increase in the emergence of antibiotic resistant bacterial strains, which has made antibiotic choices for infection control increasingly limited and more expensive. In the U.S. alone, antibiotic resistant bacteria cause at least 2 million infections and 23,000 deaths a year resulting in a $55-70 billion per year economic impact. Antibiotics are critical to the success of surgical procedures including orthopaedic prosthetic surgeries, and antibiotic resistance is occurring in nearly all bacteria that infect people, including the most common bacteria that cause orthopaedic infections, such as Staphylococcus aureus (S...
July 19, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28721080/a-cost-analysis-of-a-broad-spectrum-antibiotic-therapy-in-the-empirical-treatment-of-health-care-associated-infections-in-cirrhotic-patients
#6
Cristina Lucidi, Vincenza Di Gregorio, Giancarlo Ceccarelli, Mario Venditti, Oliviero Riggio, Manuela Merli
BACKGROUND: Early diagnosis and appropriate treatment of infections in cirrhosis are crucial. As new guidelines in this context, particularly for health care-associated (HCA) infections, would be needed, we performed a trial documenting whether an empirical broad-spectrum antibiotic therapy is more effective than the standard one for these infections. Because of the higher daily cost of broad-spectrum than standard antibiotics, we performed a cost analysis to compare: 1) total drug costs, 2) profitability of hospital admissions...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28713513/the-prevalence-and-risk-factors-of-group-b-streptococcus-colonization-in-iranian-pregnant-women
#7
Roksana Darabi, Sima Tadi, Mitra Mohit, Erfan Sadeghi, Gita Hatamizadeh, Bahareh Kardeh, Mina Etminan-Bakhsh, Yekta Parsa
BACKGROUND: Group B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions of Iran remains unknown. AIM: To determine GBS colonization prevalence and its risk factors among Iranian pregnant women. METHODS: This prospective cross-sectional study was performed on 186 pregnant women, who attended Boo-Ali hospital which is affiliated with Islamic Azad University in Tehran, Iran, from March 2014 to June 2015...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28699496/up-scaling-strategies-to-improve-the-industrial-production-of-bacitracin-at-largescale
#8
Chandra Kant Sharma, Monika Sharma
Bacitracin was discovered and named after a 7 year old American girl, Margaret Tracey in 1943 as Bacillus was isolated from her wounds. Bacillus licheniformis is usually present in soil and bird feathers. This bacterium is most commonly present around back plumage and chest of birds. There are different types of bacitracin but the one most potent is Bacitracin A. Bacitracin induced proteins are localized in bacterial membrane. Production of antibiotic initially stopped, resumed by induction of bacitracin induced protein but after few mitotic divisions microbes reverted to their vulnerable state...
July 11, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28697108/economic-evaluation-of-adjunctive-azithromycin-prophylaxis-for-cesarean-delivery
#9
Lorie M Harper, Meredith Kilgore, Jeff M Szychowski, William W Andrews, Alan T N Tita
OBJECTIVE: To compare the costs associated with adjunctive azithromycin compared with standard cefazolin antibiotic prophylaxis alone for unscheduled and scheduled cesarean deliveries. METHODS: A decision analytic model was created to compare cefazolin alone with azithromycin plus cefazolin. Published incidences of surgical site infection after cesarean delivery were used to estimate the baseline incidence of surgical site infection in scheduled and unscheduled cesarean delivery using standard antibiotic prophylaxis...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28694234/effectiveness-of-and-obstacles-to-antibiotic-streamlining-to-amoxicillin-monotherapy-in-bacteremic-pneumococcal-pneumonia
#10
Mathieu Blot, Diane Pivot, Abderrahmane Bourredjem, Arnaud Salmon-Rousseau, Claire de Curraize, Delphine Croisier, Pascal Chavanet, Christine Binquet, Lionel Piroth
BACKGROUND: Antibiotic streamlining is pivotal to reduce the emergence of resistant bacteria. However, whether streamlining is frequently performed and safe in difficult situations, such as bacteremic pneumococcal pneumonia (BPP), has still to be assessed. METHODS: All adult patients admitted to Dijon Hospital (France) from 2005 to 2013 who had BPP without complications, and were alive on the third day were enrolled. Clinical, biological, radiological, microbiological and therapeutic data were recorded...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28686461/a-large-meta-analysis-of-the-global-prevalence-rates-of-s-aureus-and-mrsa-contamination-of-milk
#11
Qianting Ou, Junli Zhou, Dongxin Lin, Chan Bai, Ting Zhang, Jialing Lin, Haoqu Zheng, Xiaojie Wang, Jiaping Ye, Xiaohua Ye, Zhenjiang Yao
Past reports have indicated a high prevalence of milk contaminated with Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA), but the pooled prevalence rates of S. aureus and MRSA in pasteurized and boiled cow's milk, raw cow's milk, and raw Caprinae milk (raw sheep's milk and raw goat's milk) and across different periods, continents, economic conditions and purchase locations remain inconsistent. We searched relevant articles published in PubMed, EMBASE, and Web of Science before July 2016...
July 7, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28683496/-prosthetic-joint-infection-after-total-hip-arthroplasty-results-of-an-online-questionnaire-about-current-diagnostic-and-therapeutic-procedures-in-107-german-hospitals
#12
Elia Raoul Langenmair, Lukas Konstantinidis, Norbert P Südkamp, Peter Helwig
Background Prosthetic hip joint infection is a common severe complication with a high socio-economic impact. The inconsistency of the available data and the absence of binding guidelines lead to a variety of diagnostic and therapeutic strategies. The aim of this study is to present the current diagnostic and therapeutic approach to treating infections after total hip arthroplasties in German hospitals, link it with current evidence, and evaluate the willingness of these hospitals to participate in prospective multicentre trials...
June 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28679110/itraq-based-quantitative-proteomic-analysis-reveals-multiple-effects-of-emodin-to-haemophilus-parasuis
#13
Li Li, Ye Tian, Jiankang Yu, Xu Song, Renyong Jia, Qiankun Cui, Wenzhi Tong, Yuanfeng Zou, Lixia Li, Lizi Yin, Xiaoxia Liang, Changliang He, Guizhou Yue, Gang Ye, Ling Zhao, Fei Shi, Cheng Lv, Sanjie Cao, Zhongqiong Yin
Haemophilus parasuis, a symbiotic bacteria of upper respiratory tract of swine, is the etiological agent of Glässer's disease, which is characterized by fibrinous polyserositis. Emodin, exhibits antibacterial activity against H. parasuis, yet the action mode has not been fully understood. In present study, isobaric tag for relative and absolute quantification (iTRAQ) method was applied to analyze the global protein alteration of H. parasuis in response to 16μg/mL Emodin. In total, 338 proteins exhibiting significant differential expressions were identified...
July 2, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28677879/economic-evaluation-of-antibiotic-therapy-versus-appendicectomy-for-the-treatment-of-uncomplicated-acute-appendicitis-from-the-appac-randomized-clinical-trial
#14
S Sippola, J Grönroos, R Tuominen, H Paajanen, T Rautio, P Nordström, M Aarnio, T Rantanen, S Hurme, P Salminen
BACKGROUND: An increasing amount of evidence supports antibiotic therapy for treating uncomplicated acute appendicitis. The objective of this study was to compare the costs of antibiotics alone versus appendicectomy in treating uncomplicated acute appendicitis within the randomized controlled APPAC (APPendicitis ACuta) trial. METHODS: The APPAC multicentre, non-inferiority RCT was conducted on patients with CT-confirmed uncomplicated acute appendicitis. Patients were assigned randomly to appendicectomy or antibiotic treatment...
July 5, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28677641/health-risks-associated-with-exposure-to-filamentous-fungi
#15
REVIEW
Mary Augustina Egbuta, Mulunda Mwanza, Olubukola Oluranti Babalola
Filamentous fungi occur widely in the environment, contaminating soil, air, food and other substrates. Due to their wide distribution, they have medical and economic implications. Regardless of their use as a source of antibiotics, vitamins and raw materials for various industrially important chemicals, most fungi and filamentous fungi produce metabolites associated with a range of health risks, both in humans and in animals. The association of filamentous fungi and their metabolites to different negative health conditions in humans and animals, has contributed to the importance of investigating different health risks induced by this family of heterotrophs...
July 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28676794/bacteriophages-contribute-to-the-spread-of-antibiotic-resistance-genes-among-foodborne-pathogens-of-the-enterobacteriaceae-family-a-review
#16
REVIEW
Anna Colavecchio, Brigitte Cadieux, Amanda Lo, Lawrence D Goodridge
Foodborne illnesses continue to have an economic impact on global health care systems. There is a growing concern regarding the increasing frequency of antibiotic resistance in foodborne bacterial pathogens and how such resistance may affect treatment outcomes. In an effort to better understand how to reduce the spread of resistance, many research studies have been conducted regarding the methods by which antibiotic resistance genes are mobilized and spread between bacteria. Transduction by bacteriophages (phages) is one of many horizontal gene transfer mechanisms, and recent findings have shown phage-mediated transduction to be a significant contributor to dissemination of antibiotic resistance genes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28674747/oral-administration-of-azithromycin-ameliorates-trypanosomosis-in-trypanosoma-congolense-infected-mice
#17
Nthatisi Innocentia Molefe, Shino Yamasaki, Adrian Miki C Macalanda, Keisuke Suganuma, Kenichi Watanabe, Xuenan Xuan, Noboru Inoue
Animal trypanosomosis is a devastating parasitic disease that is of economic importance to livestock production. The infection includes animal African trypanosomosis, surra, and dourine. The treatment is based solely on few compounds that were discovered decades ago and which are associated with severe toxicity. Furthermore, it is likely that the parasite has developed resistance towards them. Thus, there is an urgent need for new, accessible, and less toxic drugs. Azithromycin is an antibiotic with documented efficacy against Toxoplasma, Babesia, and Plasmodium...
July 4, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28668679/novel-application-of-published-risk-factors-for-methicillin-resistant-s-aureus-in-acute-bacterial-skin-and-skin-structure-infections
#18
Kimberly C Claeys, Evan J Zasowski, Abdalhamid M Lagnf, Donald P Levine, Susan L Davis, Michael J Rybak
MRSA ABSSSIs are associated with a significant clinical and economic burden, however rapid identification of MRSA remains a challenge. This study aimed to use a novel method of predictive modeling to determine those at highest risk of MRSA ABSSSIs. Risk factors for MRSA were derived from a combination of previously published literature and multivariable logistic regression of individual patient data (IPD) using the "adaptation method." A risk-scoring tool was derived from weight-proportional integer-adjusted coefficients of the predictive model...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28668171/emerging-nanotechnology-based-strategies-for-diagnosis-and-therapeutics-of-urinary-tract-infections-a-review
#19
REVIEW
M S Kumar, A P Das
At present, various diagnostic and therapeutic approaches are available for urinary tract infections. But, still the quest for development of more rapid, accurate and reliable approach is an unending process. The pathogens, especially uropathogens are adapting to new environments and antibiotics day by day rapidly. Therefore, urinary tract infections are evolving as hectic and difficult to eradicate, increasing the economic burden to the society. The technological advances should be able to compete the adaptability characteristics of microorganisms to combat their growth in new environments and thereby preventing their infections...
June 26, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28665549/quality-measurement-for-rhinosinusitis-a-review-from-the-quality-improvement-committee-of-the-american-rhinologic-society
#20
Luke Rudmik, Jose Mattos, John Schneider, Peter R Manes, Janalee K Stokken, Jivianne Lee, Thomas S Higgins, Rodney J Schlosser, Douglas D Reh, Michael Setzen, Zachary M Soler
BACKGROUND: Measuring quality outcomes is an important prerequisite to improve quality of care. Rhinosinusitis represents a high value target to improve quality of care because it has a high prevalence of disease, large economic burden, and large practice variation. In this study we review the current state of quality measurement for management of both acute (ARS) and chronic rhinosinusitis (CRS). METHODS: The major national quality metric repositories and clearinghouses were queried...
June 30, 2017: International Forum of Allergy & Rhinology
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