keyword
MENU ▼
Read by QxMD icon Read
search

antibiotic economics

keyword
https://www.readbyqxmd.com/read/28332344/impact-of-intervention-by-an-antimicrobial-stewardship-team-on-conversion-from-intravenous-to-oral-fluoroquinolones
#1
Soh Mee Park, Hyung Sook Kim, Young Mi Jeong, Jung Hwa Lee, Eunsook Lee, Euni Lee, Kyoung Ho Song, Hong Bin Kim, Eu Suk Kim
BACKGROUND: Early conversion from intravenous to oral antibiotics plays an important role in lowering the risk of catheter-associated infections, reducing the workload of nurses, decreasing direct and indirect costs, and shortening hospital stays. In August 2015, an antimicrobial stewardship program (ASP) was implemented to facilitate conversion from intravenous to oral administration of fluoroquinolones in our institute. This study evaluated the clinical and economic impact of the intervention...
March 13, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28302045/complications-following-stem-cell-therapy-in-inflammatory-bowel-disease
#2
Hongyun Wei, Xiaowei Liu, Chunhui Ouyang, Jie Zhang, Shuijiao Chen, Fanggen Lu, Linlin Chen
Pharmacotherapy and surgery constitute the mainstay of treatment for inflammatory bowel disease (IBD). However, post-treatment relapsing and recurrence persist as concerns in patients with IBD. Together with a considerable economic burden, stem cell therapy (SCT) has emerged as a promising treatment strategy in IBD, including hematopoietic stem cells (HST), mensenchymal stem cells (MSCs). HSCT could restore the immune tolerance following chemotherapy-induced immune ablation, and MSCs could affect immune cells or secret trophic factors to treat IBD...
March 15, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28299517/characterization-and-complete-genome-sequence-analysis-of-a-novel-virulent-siphoviridae-phage-against-staphylococcus-aureus-isolated-from-bovine-mastitis-in-xinjiang-china
#3
Qian Zhang, Shaozhen Xing, Qiang Sun, Guangqian Pei, Shi Cheng, Yannan Liu, Xiaoping An, Xianglilan Zhang, Yonggang Qu, Yigang Tong
Bovine mastitis is one of the most costly diseases in dairy cows worldwide. It can be caused by over 150 different microorganisms, where Staphylococcus aureus is the most frequently isolated and a major pathogen responsible for heavy economic losses in dairy industry. Although antibiotic therapy is most widely used, alternative treatments are necessary due to the increasing antibiotic resistance. Using phage for pathogen control is a promising tool in the fight against antibiotic resistance. Mainly using high-throughput sequencing, bioinformatics and our proposed phage termini identification method, we have isolated and characterized a novel virulent phage, designated as vB_SauS_IMEP5, from manure collected from dairy farms in Shihezi, Xinjiang, China, for use as a biocontrol agent against Staphylococcus aureus infections...
March 15, 2017: Virus Genes
https://www.readbyqxmd.com/read/28296951/in-silico-design-expression-and-purification-of-novel-chimeric-escherichia-coli-o157-h7-ompa-fused-to-ltb-protein-in-escherichia-coli
#4
Aytak Novinrooz, Taghi Zahraei Salehi, Roya Firouzi, Sina Arabshahi, Abdollah Derakhshandeh
E. coli O157:H7, one of the major EHEC serotypes, is capable of developing bloody diarrhea, hemorrhagic colitis (HC), and fatal hemolytic uremic syndrome (HUS) and is accompanied by high annual economic loss worldwide. Due to the increased risk of HC and HUS development following antibiotic therapy, the prevention of infections caused by this pathogen is considered to be one of the most effective ways of avoiding the consequences of this infection. The main aim of the present study was to design, express, and purify a novel chimeric protein to develope human vaccine candidate against E...
2017: PloS One
https://www.readbyqxmd.com/read/28293682/genome-sequence-of-the-thermotolerant-foodborne-pathogen-salmonella-enterica-serovar-senftenberg-atcc-43845-and-phylogenetic-analysis-of-loci-encoding-increased-protein-quality-control-mechanisms
#5
Scott V Nguyen, Gregory P Harhay, James L Bono, Timothy P L Smith, Dayna M Harhay
Salmonella enterica subsp. enterica bacteria are important foodborne pathogens with major economic impact. Some isolates exhibit increased heat tolerance, a concern for food safety. Analysis of a finished-quality genome sequence of an isolate commonly used in heat resistance studies, S. enterica subsp. enterica serovar Senftenberg 775W (ATCC 43845), demonstrated an interesting observation that this strain contains not just one, but two horizontally acquired thermotolerance locus homologs. These two loci reside on a large 341...
January 2017: MSystems
https://www.readbyqxmd.com/read/28290091/collection-of-mullet-fish-mugil-cephalus-from-west-coast-of-india-evaluation-of-its-quality-with-relation-to-food-safety
#6
Ishan H Raval, Keshob C Das, Soumya Haldar
The present study focuses on bacterial and selected heavy metal contaminations of economically important mullet fish (Mugil cephalus) collected from West coast of Gujarat, India. Molecular identification using 16S rRNA sequencing revealed the presence of Aeromonas veronii, A. mollusorum, A. cavae, A. bivalvum, and V.alginolyticus in the gill and the intestine along with some other non-pathogenic bacteria. Pathogenicity of different Aeromonas species was confirmed by hemolysin assay. Apart from pathogenicity, multidrug resistance pattern was also reported against some commonly used antibiotics...
March 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28283978/enhanced-levofloxacin-removal-from-water-using-zirconium-iv-loaded-corn-bracts
#7
Ying Yu, Wei Wang, Jing Shi, Siyi Zhu, Yachen Yan
The presence of antibiotics in the environment has attracted considerable attention due to their toxicity. In this study, agricultural waste corn bracts (CBs) modified by zirconium cations were utilized to remove levofloxacin (LEV) from wastewater. Zr-modified CBs exhibited a strong adsorption capacity (Qmax = 73 mg/g), and their desorption rate could reach 89% by simply adjusting the pH to 11. FTIR and XPS analyses indicated that the mechanism of LEV adsorption included the complexation between the ketone/carboxyl groups of LEV and the Zr atoms and the π-π electron-donor-acceptor interaction...
March 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28281915/burden-of-community-acquired-pneumonia-in-adults-over-18%C3%A2-years-of-age
#8
Filiz Kosar, Devrim Emel Alici, Basak Hacibedel, Burcu Arpınar Yigitbas, Pejman Golabi, Caglar Cuhadaroglu
This study aimed to determine the economic burden and affecting factors in adult community-acquired pneumonia (CAP) patients (≥18 years) by retrospectively evaluating the data of two centers in Istanbul province, Turkey. Data of outpatients and inpatients with CAP from January 2013 through June 2014 were evaluated. The numbers of laboratory analyses, imaging, hospitalization days, and specialist visits were multiplied by the relevant unit costs and the costs of the relevant items per patient were obtained...
March 10, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28277779/further-investigations-on-the-epidemiology-of-fowl-typhoid-in-brazil
#9
Anny Lucia Del Pilar Celis-Estupiñan, Diego Felipe Alves Batista, Marita Vedovelli Cardozo, Andrei Itajahy Secundo de Souza, Lucas Bocchini Rodrigues Alves, Adriana Maria de Almeida, Paul Andrew Barrow, Angelo Berchieri, Oliveiro Caetano de Freitas Neto
Salmonella Gallinarum (SG) causes fowl typhoid (FT), a disease responsible for economic losses to the poultry industry worldwide. FT has been considered under control in Brazil; nevertheless, since 2012 it has frequently been identified in poultry farming of several Brazilian states. The present study was aimed at assessing: (i) the pathogenicity of a SG strain recently isolated from an FT outbreak affecting chickens of both white and brown layers; (ii) the transmission of SG through eggs and hatching; (iii) the effects of antibiotic therapy on SG persistence in poultry tissues and on its vertical transmission; (iv) the genetic profiles of strains isolated over 27 years by PFGE...
March 1, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28274205/rapid-detection-of-carbapenemase-producing-klebsiella-pneumoniae-strains-derived-from-blood-cultures-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms
#10
Christina Sakarikou, Marco Ciotti, Camilla Dolfa, Silvia Angeletti, Cartesio Favalli
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE), particularly carbapenemase-producing Klebsiella pneumoniae isolates, are important causative agents of nosocomial infections associated with significant mortality rates mostly in critical wards. The rapid detection and typing of these strains is critical either for surveillance purposes and to prevent outbreaks and optimize antibiotic therapy. In this study, the MALDI-TOF MS method was used to detect rapidly these isolates from blood cultures (BCs) and to obtain proteomic profiles enable to discriminate between carbapenemase-producing and non-carbapenemase-producing strains...
March 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28273576/performance-of-microwave-treatment-for-disintegration-of-cephalosporin-mycelial-dreg-cmd-and-degradation-of-residual-cephalosporin-antibiotics
#11
Chen Cai, Huiling Liu, Bing Wang
Significant amounts of cephalosporin mycelial dreg (CMD) are still being generated from biopharmaceutical processes, representing both an economic and environmental burden for pharmaceutical factories. This study investigates the microwave (MW) treatment of CMD at a relatively mild temperature (100°C) within 15min. The results reveal that the MW treatment disintegrates the CMD efficiently and that the residual cephalosporin C (CPC) is almost degraded after sufficient irradiation. MW heating temperature strongly influences the polymer's release...
February 24, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28272303/effects-of-silver-nanoparticles-on-multiple-drug-resistant-strains-of-staphylococcus-aureus-and-pseudomonas-aeruginosa-from-mastitis-infected-goats-an-alternative-approach-for-antimicrobial-therapy
#12
Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases. Microorganisms generally acquire resistance to antibiotics through the course of antibacterial therapy. Multi-drug resistance (MDR) has become a growing problem in the treatment of infectious diseases, and the widespread use of broad-spectrum antibiotics has resulted in the development of antibiotic resistance by numerous human and animal bacterial pathogens...
March 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28271383/global-protein-expression-profile-response-of-planktonic-aeromonas-hydrophila-exposed-to-chlortetracycline
#13
Wanxin Li, Zujie Yao, Xiangyu Zhang, Fang Huang, Wenxiong Lin, Xiangmin Lin
The antibiotics resistance phenomena of Aeromonas hydrophila has become serious economic and public health problems for the world aquaculture industry and human health care. In this study, to investigate the instinct antibiotics adaptive mechanism of this pathogen, iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) based quantitative proteomics technologies were performed to compare the differential expression of A. hydrophila in planktonic status in response to chlortetracycline (CTC) stress and then identified total 1552 proteins including 285 altered proteins with 90 increasing and 195 decreasing abundance proteins...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28262925/washout-policies-in-long-term-indwelling-urinary-catheterisation-in-adults
#14
REVIEW
Ashley J Shepherd, William G Mackay, Suzanne Hagen
BACKGROUND: People requiring long-term bladder draining with an indwelling catheter can experience catheter blockage. Regimens involving different solutions can be used to wash out catheters with the aim of preventing blockage. This is an update of a review published in 2010. OBJECTIVES: To determine if certain washout regimens are better than others in terms of effectiveness, acceptability, complications, quality of life and critically appraise and summarise economic evidence for the management of long-term indwelling urinary catheterisation in adults...
March 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28255093/what-drives-inappropriate-antibiotic-dispensing-a-mixed-methods-study-of-pharmacy-employee-perspectives-in-haryana-india
#15
Anna K Barker, Kelli Brown, Muneeb Ahsan, Sharmila Sengupta, Nasia Safdar
OBJECTIVES: There are only 0.70 licensed physicians per 1000 people in India. Thus, pharmacies are a primary source of healthcare and patients often seek their services directly, especially in village settings. However, there is wide variability in a pharmacy employee's training, which contributes to inappropriate antibiotic dispensing and misuse. These practices increase the risk of antibiotic resistance and poor patient outcomes. This study seeks to better understand the factors that drive inappropriate antibiotic dispensing among pharmacy employees in India's village communities...
March 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28252178/isolation-identification-and-pathogenicity-of-vibrio-harveyi-the-causal-agent-of-skin-ulcer-disease-in-juvenile-hybrid-groupers-epinephelus-fuscoguttatus%C3%A2-%C3%A3-%C3%A2-epinephelus-lanceolatus
#16
G M Shen, C Y Shi, C Fan, D Jia, S Q Wang, G S Xie, G Y Li, Z L Mo, J Huang
The hybrid grouper, Epinephelus fuscoguttatus (♀) × Epinephelus lanceolatus (♂), is a newly bred cultivated marine fish species of high economic value. However, a skin ulcer disease with high mortality has occurred, and the responsible pathogen remains unknown. In this study, we summarized the epidemic status and external signs of this disease. We screened potential pathogens and finally isolated one bacterial strain ML01 from affected fish. We subjected healthy juvenile hybrid groupers to bacterial challenge tests with the isolate by immersion, immersion after dermal abrasion and intraperitoneal injection, respectively...
March 2, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28251882/solid-phase-extraction-preconcentration-method-for-simultaneous-determination-of-cadmium-lead-and-nickel-in-poultry-supplements
#17
Jameel Ahmed Baig, Hina Daud Memon, Syed Ali Imran Bukhari, Tasneem Gul Kazi, Hassan Imran Afridi, Hafiz Muhammad Naseer, Latif Elci
A new simple, selective, and economical preconcentration method was developed for the determination of Cd, Pb, and Ni in poultry antibiotics and supplements. The proposed preconcentration procedure is based on SPE using 8-hydroxyquinoline and Amberlite IRC-50 resin as complex and adsorbent, respectively. The determination was carried out by microsample injection system (MIS) flame atomic absorption spectroscopy (FAAS). Several analytical parameters were examined, including pH, type of resin, amount of resin, type of eluent, eluent volume, flow rate, sample volume, and interference of diverse ions...
March 2, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28251880/choosing-wisely-canada%C3%A2-five-tests-procedures-and-treatments-to-question-in-emergency-medicine
#18
Amy H Y Cheng, Sam Campbell, Lucas B Chartier, Tom Goddard, Kirk Magee, Jill McEwen, Atul K Kapur, Brian R Holroyd, Suneel Upadhye, Stephanie Couperthwaite, Brian H Rowe
OBJECTIVES: Choosing Wisely Canada (CWC) is an initiative to encourage patient-physician discussions about the appropriate, evidence based use of medical tests, procedures and treatments. We present the Canadian Association of Emergency Physicians' (CAEP) top five list of recommendations, and the process undertaken to generate them. METHODS: The CAEP Expert Working Group (EWG) generated a candidate list of 52 tests, procedures, and treatments in emergency medicine whose value to care was questioned...
March 2, 2017: CJEM
https://www.readbyqxmd.com/read/28250915/the-reset-mindset-model-applied-on-decreasing-antibiotic-usage-in-dairy-cattle-in-the-netherlands
#19
REVIEW
T J G M Lam, J Jansen, R J Wessels
BACKGROUND: Prudent use of antibiotics is important to prevent antibiotic resistance in humans and in animals. For this reason politicians demanded a decrease of total antibiotic use and of use of critically important antibiotics in animal husbandry in the Netherlands. In the dairy sector the use of antibiotics almost halved in the years 2009-2015, with a decrease of the use of critically important antibiotics to very low levels. THEORY OF BEHAVIOUR CHANGE: To realize a sustainable decrease in antibiotic usage, the mindset towards the subject was considered crucial...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28246379/the-antibiotic-resistance-crisis-with-a-focus-on-the-united-states
#20
REVIEW
Evan Martens, Arnold L Demain
Beginning with the discovery of penicillin by Alexander Fleming in the late 1920s, antibiotics have revolutionized the field of medicine. They have saved millions of lives each year, alleviated pain and suffering, and have even been used prophylactically for the prevention of infectious diseases. However, we have now reached a crisis where many antibiotics are no longer effective against even the simplest infections. Such infections often result in an increased number of hospitalizations, more treatment failures and the persistence of drug-resistant pathogens...
March 1, 2017: Journal of Antibiotics
keyword
keyword
38653
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"