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Randomised Control Study

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https://www.readbyqxmd.com/read/28346536/water-sanitation-and-hygiene-wash-and-environmental-risk-factors-for-soil-transmitted-helminth-intensity-of-infection-in-timor-leste-using-real-time-pcr
#1
Suzy J Campbell, Susana V Nery, Rebecca Wardell, Catherine A D'Este, Darren J Gray, James S McCarthy, Rebecca J Traub, Ross M Andrews, Stacey Llewellyn, Andrew J Vallely, Gail M Williams, Archie C A Clements
BACKGROUND: No investigations have been undertaken of risk factors for intensity of soil-transmitted helminth (STH) infection in Timor-Leste. This study provides the first analysis of risk factors for intensity of STH infection, as determined by quantitative PCR (qPCR), examining a broad range of water, sanitation and hygiene (WASH) and environmental factors, among communities in Manufahi District, Timor-Leste. METHODS: A baseline cross-sectional survey of 18 communities was undertaken as part of a cluster randomised controlled trial, with additional identically-collected data from six other communities...
March 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28346315/the-effects-of-10-weeks-integrated-neuromuscular-training-on-fundamental-movement-skills-and-physical-self-efficacy-in-6-7-year-old-children
#2
Michael J Duncan, Emma L J Eyre, Samuel W Oxford
Integrated neuromuscular training (INT) has been suggested as an effective means to enhance athletic potential in children. However, few studies have reported the effects of school based INT programs. This study examined the effect of INT on process and product fundamental movement skill measures and physical self-efficacy in 6-7 year old children. Ninety-four children from 2 primary schools were randomised into either a 10 week INT program or a control group CON (n =41) group. Results indicated significantly greater increases in process FMS scores in INT vs CON (P = 0...
March 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28345503/physical-fitness-and-shapes-of-subcortical-brain-structures-in-children
#3
Francisco B Ortega, Daniel Campos, Cristina Cadenas-Sanchez, Signe Altmäe, Cristina Martínez-Zaldívar, Miguel Martín-Matillas, Andrés Catena, Cristina Campoy
A few studies have recently reported that higher cardiorespiratory fitness is associated with higher volumes of subcortical brain structures in children. It is, however, unknown how different fitness measures relate to shapes of subcortical brain nuclei. We aimed to examine the association of the main health-related physical fitness components with shapes of subcortical brain structures in a sample of forty-four Spanish children aged 9·7 (sd 0·2) years from the NUtraceuticals for a HEALthier life project...
March 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28345499/synbiotic-supplementation-in-lean-patients-with-non-alcoholic-fatty-liver-disease-a-pilot-randomised-double-blind-placebo-controlled-clinical-trial
#4
Fatemeh Mofidi, Hossein Poustchi, Zahra Yari, Babak Nourinayyer, Shahin Merat, Maryam Sharafkhah, Reza Malekzadeh, Azita Hekmatdoost
Although non-alcoholic fatty liver disease (NAFLD) is the leading aetiology of liver disorders in the world, there is no proven treatment for NAFLD patients with normal or low BMI. The aim of this study was to evaluate the efficacy of synbiotics supplementation in NAFLD patients with normal or low BMI. In this randomised, double-blind, placebo-controlled, clinical trial, fifty patients with NAFLD were assigned to take either a synbiotic supplement or a placebo capsule for 28 weeks. Both groups were advised to follow a healthy lifestyle...
March 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28345139/utility-of-%C3%AE-hcg-monitoring-in-the-follow-up-of-medical-management-of-miscarriage
#5
Scott G Petersen, Anneliese R Perkins, Kristen S Gibbons, Julia I Bertolone, Kassam Mahomed
OBJECTIVE: To evaluate the percentage change in total βeta-unit human chorionic gonadotropin (βhCG) levels (%ΔβhCG) in the prediction of treatment outcomes following intravaginal misoprostol for missed miscarriage before 13 weeks. METHODS: A secondary analysis of a randomised controlled study of medical management of miscarriage was performed. Total βhCG levels were collected before misoprostol (baseline) and after a planned seven day interval (follow-up), when a transvaginal ultrasound (TVUS) reported a gestational sac as present or not...
March 27, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28345122/effect-of-laser-on-pain-relief-and-wound-healing-of-recurrent-aphthous-stomatitis-a-systematic-review
#6
REVIEW
Valerie G A Suter, Sophia Sjölund, Michael M Bornstein
The aim of this systematic review was to assess a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS). The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency. A PICO approach was used as a search strategy in Medline, Embase and Cochrane databases. After scanning and excluding titles, abstracts and full texts, 11 studies (ten RCTs and one non-randomised controlled trial) were included. Study selection and data extraction was done by two observers...
March 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28344112/efficacy-and-safety-of-once-weekly-semaglutide-versus-once-daily-insulin-glargine-as-add-on-to-metformin-with-or-without-sulfonylureas-in-insulin-naive-patients-with-type-2-diabetes-sustain-4-a-randomised-open-label-parallel-group-multicentre-multinational
#7
Vanita R Aroda, Stephen C Bain, Bertrand Cariou, Milivoj Piletič, Ludger Rose, Mads Axelsen, Everton Rowe, J Hans DeVries
BACKGROUND: Several pharmacological treatment options are available for type 2 diabetes; however, many patients do not achieve optimum glycaemic control and therefore new therapies are necessary. We assessed the efficacy and safety of semaglutide, a glucagon-like peptide-1 (GLP-1) analogue in clinical development, compared with insulin glargine in patients with type 2 diabetes who were inadequately controlled with metformin (with or without sulfonylureas). METHODS: We did a randomised, open-label, non-inferiority, parallel-group, multicentre, multinational, phase 3a trial (SUSTAIN 4) at 196 sites in 14 countries...
March 23, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28343401/effect-of-probiotic-on-innate-inflammatory-response-and-viral-shedding-in-experimental-rhinovirus-infection-a-randomised-controlled-trial
#8
R B Turner, J A Woodfolk, L Borish, J W Steinke, J T Patrie, L M Muehling, S Lahtinen, M J Lehtinen
Ingestion of probiotics appears to have modest effects on the incidence of viral respiratory infection. The mechanism of these effects is not clear; however, there is evidence from animal models that the probiotic may have an effect on innate immune responses to pathogens. The purpose of this randomised, placebo-controlled study was to determine the effect of administration of Bifidobacterium animalis subspecies lactis Bl-04 on innate and adaptive host responses to experimental rhinovirus challenge. The effect on the response of chemokine (C-X-C motif) ligand 8 (CXCL8) to rhinovirus infection was defined as the primary endpoint for the study...
March 27, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28342907/active-placebo-control-groups-of-pharmacological-interventions-were-rarely-used-but-merited-serious-consideration-a-methodological-overview
#9
Jakob Solgaard Jensen, Andreas Ørsted Bielefeldt, Asbjørn Hróbjartsson
OBJECTIVES: Active placebos are control interventions that mimic the side-effects of the experimental interventions in randomised trials and are sometimes used to reduce the risk of unblinding. We wanted to assess how often randomised clinical drug trials implement active placebo control groups; to provide a catalogue, and a characterisation, of such trials; and to analyse methodological arguments for and against use of active placebo. STUDY DESIGN: An overview consisting of three thematically linked sub-studies...
March 22, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28342891/cost-utility-of-group-acceptance-and-commitment-therapy-for-fibromyalgia-versus-recommended-drugs-an-economic-analysis-alongside-a-6-month-randomised-controlled-trial-conducted-in-spain-effigact-study
#10
Juan V Luciano, Francesco D'Amico, Albert Feliu-Soler, Lance M McCracken, Jaume Aguado, María T Peñarrubia-María, Martin Knapp, Antoni Serrano-Blanco, Javier García-Campayo
The aim of this study was to analyse the cost-utility of a group-based form of Acceptance and Commitment Therapy (GACT) in patients with fibromyalgia (FM) compared to patients receiving recommended pharmacological treatment (RPT) or on a waiting list (WL). The data were derived from a previously published study, an RCT that focused on clinical outcomes. Health economic outcomes included health-related quality of life and healthcare use at baseline and at 6-month follow-up using the EuroQol (EQ-5D-3L) and the Client Service Receipt Inventory (CSRI), respectively...
March 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28342731/preferred-management-of-primary-deep-arm-vein-thrombosis
#11
REVIEW
F J Vazquez, P Paulin, D Poodts, E Gándara
OBJECTIVE: Given its rarity, the management of primary upper extremity deep vein thrombosis is controversial. Although anticoagulation alone is commonly advocated for its treatment, it is unclear if this will reduce the risk of developing post-thrombotic syndrome (PTS). The aim of this "Evidence Driven" Clinical Scenario is to evaluate whether more aggressive treatments (including catheter directed thrombolysis or surgery) might help reduce the risk of PTS or recurrent venous thromboembolism in patients with primary upper extremity deep vein thrombosis (DVT)...
March 22, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28342682/a-home-program-of-strength-training-movement-strategy-training-and-education-did-not-prevent-falls-in-people-with-parkinson-s-disease-a-randomised-trial
#12
Meg E Morris, Nicholas F Taylor, Jennifer Watts, Andrew Evans, Malcolm Horne, Peter Kempster, Mary Danoudis, Jennifer J McGinley, Clarissa Martin, Hylton B Menz
QUESTIONS: For people with idiopathic Parkinson's disease, does a 6-week, comprehensive, home exercise program reduce falls and disability and improve health-related quality of life? Is the program cost-effective? DESIGN: Randomised, controlled trial with concealed allocation and assessor blinding. PARTICIPANTS: One hundred and thirty-three community-dwelling adults with Parkinson's disease. INTERVENTION: The experimental group completed a 6-week home program comprising progressive resistance strength training, movement strategy training and falls education...
March 14, 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28342633/pca3-as-a-second-line-biomarker-in-a-prospective-controlled-randomized-opportunistic-prostate-cancer-screening-programme
#13
J Rubio-Briones, J Casanova, F Martínez, J L Domínguez-Escrig, A Fernández-Serra, R Dumont, M Ramírez-Backhaus, A Gómez-Ferrer, A Collado, L Rubio, A Molina, M Vanaclocha, D Sala, J A Lopez-Guerrero
OBJECTIVES: PCA3 performance as a single second line biomarker is compared to the European Randomised Study of Screening for Prostate Cancer risk calculator model 3 (ERSPC RC-3) in an opportunistic screening in prostate cancer (PCa). MATERIAL AND METHODS: 5,199 men, aged 40-75y, underwent prostate-specific antigen (PSA) screening and digital rectal examination (DRE). Men with a normal DRE and PSA ≥3ng/ml had a PCA3 test done. All men with PCA3 ≥35 underwent an initial biopsy (IBx) -12 cores-...
March 22, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28342389/pilot-randomised-controlled-trial-comparing-the-risk-of-neonatal-respiratory-distress-in-elective-caesarean-section-at-38-weeks-gestation-following-a-course-of-corticosteroids-versus-caesarean-at-39-weeks
#14
Nicolas Sananès, Antoine Koch, Benoît Escande, Germain Aissi, Gabrielle Fritz, Emmanuel Roth, Michèle Weil, Ahmad Bakri, Chantal Bolender, Nicolas Meyer, Christophe Vayssiere, Adrien Gaudineau, Israël Nisand, Romain Favre, Pierre Kuhn, Bruno Langer
INTRODUCTION: The objective of this study was to compare neonatal respiratory morbidity and rate of emergency caesarean section between elective caesarean sections at 38 gestational weeks following a course of corticosteroids and planned caesarean sections at 39 gestational weeks. MATERIAL AND METHODS: This was a multicentre randomised controlled trial. The study was conducted between 2007 and 2013 in level 2 and 3 maternity units in France. A total of 208 women with an indication for elective caesarean section were enrolled and 200 analysed in per-protocol analysis...
March 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28341726/rest-and-treatment-rehabilitation-following-sport-related-concussion-a-systematic-review
#15
REVIEW
Kathryn J Schneider, John J Leddy, Kevin M Guskiewicz, Tad Seifert, Michael McCrea, Noah D Silverberg, Nina Feddermann-Demont, Grant L Iverson, Alix Hayden, Michael Makdissi
AIM OR OBJECTIVE: The objective of this systematic review was to evaluate the evidence regarding rest and active treatment/rehabilitation following sport-related concussion (SRC). DESIGN: Systematic review. DATA SOURCES: MEDLINE (OVID), CINAHL (EbscoHost), PsycInfo (OVID), Cochrane Central Register of Controlled Trials (OVID), SPORTDiscus (EbscoHost), EMBASE (OVID) and Proquest DissertationsandTheses Global (Proquest) were searched systematically...
March 24, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28341722/sciatic-and-femoral-nerve-blockade-using-bupivacaine-alone-or-in-combination-with-dexmedetomidine-or-buprenorphine-in-cats
#16
M C Evangelista, G M Doodnaught, D T Fantoni, P V M Steagall
The aim of this study was to determine the onset and offset of antinociception after sciatic (ScN) and femoral (FN) nerve blocks. Six healthy adult cats (4.8±1.3years; 4.3±0.4 kg) were included in a randomised, crossover, blinded and controlled study. Following sedation with dexmedetomidine (25 µg/kg, intramuscular), each ScN and FN injection was performed using 0.1 ml/kg of saline (CONTROL), bupivacaine (0.46 per cent, 0.46 mg/kg; BUPI), bupivacaine and dexmedetomidine (1 µg/kg; BUPI-DEX) or bupivacaine and buprenorphine (2...
March 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28341688/global-cardiovascular-risk-assessment-in-the-primary-prevention-of-cardiovascular-disease-in-adults-systematic-review-of-systematic-reviews
#17
Dylan R J Collins, Alice C Tompson, Igho J Onakpoya, Nia Roberts, Alison M Ward, Carl J Heneghan
OBJECTIVE: To identify, critically appraise and summarise existing systematic reviews on the impact of global cardiovascular risk assessment in the primary prevention of cardiovascular disease (CVD) in adults. DESIGN: Systematic review of systematic reviews published between January 2005 and October 2016 in The Cochrane Library, EMBASE, MEDLINE or CINAHL databases, and post hoc analysis of primary trials. PARTICIPANTS, INTERVENTIONS, OUTCOMES: Systematic reviews of interventions involving global cardiovascular risk assessment relative to no formal risk assessment in adults with no history of CVD...
March 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28340861/a-randomised-double-blind-placebo-controlled-long-term-extension-study-of-the-efficacy-safety-and-tolerability-of-fixed-dose-combinations-of-aclidinium-formoterol-or-monotherapy-in-the-treatment-of-chronic-obstructive-pulmonary-disease
#18
Anthony D'Urzo, Stephen Rennard, Edward Kerwin, James F Donohue, Alejhandra Lei, Eduard Molins, Anne Leselbaum
INTRODUCTION: Aclidinium bromide/formoterol fumarate (AB/FF) 400/12 μg efficacy and safety was demonstrated in two 6-month Phase III studies (AUGMENT and ACLIFORM) and a 12-month study in patients with moderate to severe chronic obstructive pulmonary disease (COPD). This Phase III, double-blind, placebo-controlled, 6-month AUGMENT extension investigated the long-term safety and tolerability of AB/FF 400/12 μg (NCT01572792). METHODS: Patients were randomised in AUGMENT (1:1:1:1:1) to twice-daily AB/FF 400/12 μg, AB/FF 400/6 μg, AB 400 μg, FF 12 μg or placebo...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28340625/habit-training-versus-habit-training-with-direct-visual-biofeedback-in-adults-with-chronic-constipation-study-protocol-for-a-randomised-controlled-trial
#19
Christine Norton, Anton Emmanuel, Natasha Stevens, S Mark Scott, Ugo Grossi, Sybil Bannister, Sandra Eldridge, James M Mason, Charles H Knowles
BACKGROUND: Constipation affects up to 20% of adults. Chronic constipation (CC) affects 1-2% of adults. Patient dissatisfaction is high; nearly 80% feel that laxative therapy is unsatisfactory and symptoms have significant impact on quality of life. There is uncertainty about the value of specialist investigations and whether equipment-intensive therapies using biofeedback confer additional benefit when compared with specialist conservative advice. METHODS/DESIGN: A three-arm, parallel-group, multicentre randomised controlled trial...
March 24, 2017: Trials
https://www.readbyqxmd.com/read/28340513/mendelian-randomisation-implicates-hyperlipidaemia-as-a-risk-factor-for-colorectal-cancer
#20
Henry Rodriguez-Broadbent, Philip J Law, Amit Sud, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Samuli Ripatti, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Lynn Martin, Ella Barclay, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Timothy S Maughan, Richard Kaplan, Rachel Kerr, David Kerr, Michael N Passarelli, Jane C Figueiredo, Daniel D Buchanan, Aung K Win, John L Hopper, Mark A Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A Aaltonen, Jeremy P Cheadle, Ian P Tomlinson, Malcolm G Dunlop, Richard S Houlston
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variables (IV). We calculated MR estimates for each risk factor with CRC using SNP-CRC associations from 9,254 cases and 18,386 controls...
March 24, 2017: International Journal of Cancer. Journal International du Cancer
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