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Levent Albayrak, Kamil Khanipov, George Golovko, Yuriy Fofanov
Motivation: Identification of complex relationships among members of microbial communities is key to understand and control the microbiota. Co-exclusion is arguably one of the most important patterns reflecting microorganisms' intolerance to each other's presence. Knowing these relations opens an opportunity to manipulate microbiotas, personalize anti-microbial and probiotic treatments as well as guide microbiota transplantation. The co-exclusion pattern however, cannot be appropriately described by a linear function nor its strength be estimated using covariance or (negative) Pearson and Spearman correlation coefficients...
June 5, 2018: Bioinformatics
Joseph A Kotarba, Kevin Wooten
Introduction: This paper reports on the baseline stage of a qualitative evaluation of the application of the Innovative Scorecard (ISC) to the Clinical and Translational Science Award (CTSA) at the University of Texas Medical Branch (UTMB) at Galveston. The ISC is adopted from the established Balanced Scorecard system for strategic planning and performance management. In formulating the evaluation, we focused on the organizational identity literature. Methods: The initial evaluation consisted of a series of semi-structured interviews with 22 participants of the ISC Boot Camp conducted in July 2015...
October 2017: Journal of Clinical and Translational Science
Gabriel Hundeshagen, David N Herndon, Robert P Clayton, Paul Wurzer, Alexis McQuitty, Kristofer Jennings, Ludwik Branski, Vanessa N Collins, Nicole Ribeiro Marques, Celeste C Finnerty, Oscar E Suman, Michael P Kinsky
Background: Sepsis, trauma, and burn injury acutely depress systolic and diastolic cardiac function; data on long-term cardiac sequelae of pediatric critical illness are sparse. This study evaluated long-term systolic and diastolic function, myocardial fibrosis, and exercise tolerance in survivors of severe pediatric burn injury. Methods: Subjects at least 5 years after severe burn (post-burn:PB) and age-matched healthy controls (HC) underwent echocardiography to quantify systolic function (ejection fraction[EF%]), diastolic function (E/e'), and myocardial fibrosis (calibrated integrated backscatter) of the left ventricle...
December 2017: The lancet child & adolescent health
Camille Loftin, Holly West
PURPOSE: Evidence suggests that confidence in learning may improve academic performance. The purpose of this study was to evaluate the University of Texas Medical Branch (UTMB) physician assistant (PA) student's self-efficacy for learning end-of-life (EOL) care after a team-based learning (TBL) activity. Confidence in the PA student's critical thinking skills after a TBL activity was also assessed. METHODS: This research used a pretest-posttest 2-group design. Eighty-seven UTMB didactic-year PA students were randomly assigned to a TBL group (n = 43) or non-TBL group (n = 44)...
June 2017: Journal of Physician Assistant Education
Surendra S Negi, Werner Braun
The phenomenon of cross-reactivity between allergenic proteins plays an important role to understand how the immune system recognizes different antigen proteins. Allergen proteins are known to cross-react if their sequence comparison shows a high sequence identity which also implies that the proteins have a similar 3D fold. In such cases, linear sequence alignment methods are frequently used to predict cross-reactivity between allergenic proteins. However, the prediction of cross-reactivity between distantly related allergens continues to be a challenging task...
April 1, 2017: Bioinformatics
Tyra T Gross, Mahbubur Rahman, Abigail M Wright, Jacqueline M Hirth, Kwabena O Sarpong, Richard E Rupp, Alan D Barrett, Abbey B Berenson
Introduction The objective of this qualitative study was to assess healthcare providers' acceptability of an ongoing postpartum human papillomavirus (HPV) vaccination program in Southeast Texas and its integration into everyday clinical care. Methods In 2012, the Department of Obstetrics & Gynecology at the University of Texas Medical Branch (UTMB) began offering HPV vaccination as part of standard postpartum care to increase vaccination rates among young women in Galveston County. Initial vaccine doses were offered on the postpartum unit while subsequent doses were coordinated with postpartum and well-baby visits...
November 2016: Maternal and Child Health Journal
Yan Xie, Gregorio Garza, Jianli Dong
Hepatitis C virus (HCV) genotype/subtype data are routinely generated in clinical laboratories to guide treatment. Genotype data can also inform genotype distribution and molecular epidemiology of HCV infections in patient populations and geographical regions that clinics/laboratories serve. The aim of this study was to determine the distribution of HCV genotypes/subtypes and their association with demographic characteristics among the patients that were routinely tested in the Molecular Diagnostics Laboratory at The University of Texas Medical Branch (UTMB) at Galveston...
May 2016: Laboratory Medicine
Lisa R Nash, Tricia C Elliott, Jorge Duchicela
The University of Texas Medical Branch in Galveston (UTMB) family medicine residency program established a rural training track (RTT) in Weimar, Texas, in 2000. The UTMB-RTT provided a training environment designed specifically to prepare family physicians for rural practice in Texas. From 2000 to 2015, 17 family medicine residents completed their training and graduated from the UTMB-RTT. Despite successes with graduate training, rural placement after program completion, and recruitment of underrepresented minorities, the UTMB-RTT closed in June 2015...
February 1, 2016: Texas Medicine
Andrzej S Kudlicki
The G-quadruplex is a non-canonical DNA structure biologically significant in DNA replication, transcription and telomere stability. To date, only G4s with all guanines originating from the same strand of DNA have been considered in the context of the human nuclear genome. Here, I discuss interstrand topological configurations of G-quadruplex DNA, consisting of guanines from both strands of genomic DNA; an algorithm is presented for predicting such structures. I have identified over 550,000 non-overlapping interstrand G-quadruplex forming sequences in the human genome--significantly more than intrastrand configurations...
2016: PloS One
Richard Foy
Healthy partnerships with hospital administration are essential for any neurodiagnostics program to experience growth and development. The differing backgrounds of business-oriented administrators and clinically oriented technologists can result in challenges with various departmental initiatives and lead to ineffective outcomes when seeking to balance high-quality, patient-oriented care with efficient and profitable operations. Over the course of a two-year period, The University of Texas Medical Branch at Galveston (UTMB Health) implemented several changes that have led to better patient care outcomes...
March 2015: Neurodiagnostic Journal
Erwin Sentausa, Khalid El Karkouri, Thi-Tien Nguyen, Aurélia Caputo, Didier Raoult, Pierre-Edouard Fournier
Rickettsia hoogstraalii is a tick-associated member of the spotted fever group rickettsiae that is geographically widely distributed. We report here the draft genome of R. hoogstraalii strain Croatica(T) (=DSM 22243 = UTMB 00003), which was isolated from Haemaphysalis sulcata ticks collected in Croatia.
2014: Genome Announcements
Burak Zeybek, Tufan Oge, Cemil Hakan Kılıç, Mostafa A Borahay, Gökhan Sami Kılıç
OBJECTIVE: To analyse the steps taking place in the operating room (OR) before the console time starts in robot-assisted gynaecologic surgery and to identify potential ways to decrease non-operative time in the OR. MATERIAL AND METHODS: Thirteen consecutive robotic cases for benign gynaecologic disease at the Department of Obstetrics and Gynecology at University of Texas Medical Branch (UTMB) were retrospectively reviewed. The collected data included the specific terms 'Anaesthesia Done' (step 1), 'Drape Done' (step 2), and 'Trocar In' (step 3), all of which refer to the time before the actual surgery began and OR charges were evaluated as level 3, 4, and 5 for open abdominal/vaginal hysterectomy, laparoscopic hysterectomy, and robot-assisted hysterectomy, respectively...
2014: Journal of the Turkish German Gynecological Association
Cara Geary, Julie McKee, Catalina Triana, Era Buck, Scott Walton, David Valdez, Victor Sierpina, Mary Jo Kreitzer
No abstract text is available yet for this article.
May 2014: Explore: the Journal of Science and Healing
Sheila Z Jalalat, Lindsey Hunter-Ellul, Richard F Wagner
The Dermatology Interest Group (DIG) at the University of Texas Medical Branch (UTMB) blog ( was created in 2004 with the aims of increasing communication and collaboration among students, faculty, residents, and alumni, promoting educational opportunities, and fostering the missions for which DIG was created. This blog is unique, because its frequent activity is directed toward the educational and professional needs of medical students and residents. We assessed the use of this blog by evaluating the number of blog views and audience members with relationship to the number of posts and post content over time via a tracking system...
September 2013: Clinics in Dermatology
Leigh Ann Cates, Debra Armentrout
Neonatal nurse practitioners (NNPs) have a crucial role in the management and care of critically ill newborns and infants in the neonatal intensive care unit. Their role responsibilities range from daily management of care, oversight of unit and bedside education, execution of advanced procedures, and attendance at high-risk deliveries. During their educational program, there is a mix of didactic and clinical training. To ensure that their graduates are able to competently care for neonatal patients in the ever-advancing neonatal world, the NNP program at the University of Texas Medical Branch-Galveston (UTMB), has implemented simulation-based training into every clinical course...
April 2013: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
William J Calhoun, Kevin Wooten, Suresh Bhavnani, Karl E Anderson, Jean Freeman, Allan R Brasier
Translational science requires that scientists from multiple disciplines work together to improve the prevention, diagnosis, and treatment of human disease. Although a literature exists on the design and management of multidisciplinary teams, little has been written on multidisciplinary translational teams (MTTs). MTTs are distinct hybrid entities, with goals taken from both industry and academic models. We identified 30 design factors in 10 domains from a literature survey relevant to our MTT model: specific goals, structures, and processes...
February 2013: Clinical and Translational Science
Michael B Sherman, Juan Trujillo, Ian Leahy, Dennis Razmus, Robert Dehate, Paul Lorcheim, Mark A Czarneski, Domenica Zimmerman, Je T'aime M Newton, Andrew D Haddow, Scott C Weaver
A unique cryo-electron microscopy facility has been designed and constructed at the University of Texas Medical Branch (UTMB) to study the three-dimensional organization of viruses and bacteria classified as select agents at biological safety level (BSL)-3, and their interactions with host cells. A 200keV high-end cryo-electron microscope was installed inside a BSL-3 containment laboratory and standard operating procedures were developed and implemented to ensure its safe and efficient operation. We also developed a new microscope decontamination protocol based on chlorine dioxide gas with a continuous flow system, which allowed us to expand the facility capabilities to study bacterial agents including spore-forming species...
March 2013: Journal of Structural Biology
Kristi Fraase, Jeffrey Hart, Hai Wu, Xiaofan Pang, Ly Ma, Felicitas Grant, Albert Li, Alan Lennon, Peter C Hu, Jianli Dong
Cervical cancer is the third most common type of cancer in women worldwide. A persistent infection with high risk (HR) human papillomavirus (HPV) is necessary for cervical cancer to occur. However, the great majority of women that are infected with HR-HPV will not develop cervical cancer, indicating that HR-HPV alone is not adequate to drive the development of cervical cancer, suggesting the involvement of cofactors. The BK polyomavirus (BKV) establishes latency near cervical tissue in the urogenital tract and is frequently detected in the urine, especially in immunosuppressed patients, and hence may coexist with HR-HPV...
2012: Annals of Clinical and Laboratory Science
Alexey V Nefedov, Rovshan G Sadygov
BACKGROUND: Enumeration of all theoretically possible amino acid compositions is an important problem in several proteomics workflows, including peptide mass fingerprinting, mass defect labeling, mass defect filtering, and de novo peptide sequencing. Because of the high computational complexity of this task, reported methods for peptide enumeration were restricted to cover limited mass ranges (below 2 kDa). In addition, implementation details of these methods as well as their computational performance have not been provided...
2011: BMC Bioinformatics
Shu-Ting Ren, Li-Hui Long, Mei Wang, Yi-Ping Li, Hao Qin, Hui Zhang, Bo-Bin Jing, Ying-Xue Li, Wei-Jin Zang, Bing Wang, Xin-Liang Shen
Our previous study has shown that P1 polypeptide-loaded microbubbles (clot-targeted microbubbles, TMB) are effective for thrombolysis and recanalization in a 0.5 h cerebral thrombosis rabbit model when combined with low-frequency ultrasound (LFUS, 0.8 MHz). However, the thrombolytic effects of TMB combined with LFUS are still unclear in a 6 h cerebral thrombosis rabbit model, which closely resembles human embolic stroke. Aiming to extend the 3 h therapeutic window limitation of thrombolytic drugs, a 6 h cerebral thrombosis model of common carotid artery (CCA) occlusion was induced in rabbits, and thrombolysis using TMB by intra-arterial (IA) and intravenous (IV) application combined with LFUS was then compared to untargeted microbubbles (UTMB) and recombinant tissue plasminogen activator (rt-PA)...
January 2012: Journal of Thrombosis and Thrombolysis
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