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https://www.readbyqxmd.com/read/28097502/should-we-routinely-use-debtace-for-unresectable-hcc-ctace-versus-debtace-a-single-center-survival-analysis
#1
M Massani, T Stecca, C Ruffolo, N Bassi
Conventional trans-arterial chemoembolization (cTACE) for intermediate stage hepatocellular carcinoma (HCC) achieves a partial response in up to 72% of patients and improves median survival. Drug-eluting-beads-TACE (DEBTACE) improves treatment efficacy and tolerance as compared to cTACE. Our aim was to retrospectively evaluate our experience in the treatment of intermediate/advanced HCC with cTACE versus DEBTACE. Overall survival (OS) was the first endpoint. We retrospectively considered our department register data between 2006 and 2012...
January 17, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28096363/an-rna-based-signature-enables-high-specificity-detection-of-circulating-tumor-cells-in-hepatocellular-carcinoma
#2
Mark Kalinich, Irun Bhan, Tanya T Kwan, David T Miyamoto, Sarah Javaid, Joseph A LiCausi, John D Milner, Xin Hong, Lipika Goyal, Srinjoy Sil, Melissa Choz, Uyen Ho, Ravi Kapur, Alona Muzikansky, Huidan Zhang, David A Weitz, Lecia V Sequist, David P Ryan, Raymond T Chung, Andrew X Zhu, Kurt J Isselbacher, David T Ting, Mehmet Toner, Shyamala Maheswaran, Daniel A Haber
Circulating tumor cells (CTCs) are shed into the bloodstream by invasive cancers, but the difficulty inherent in identifying these rare cells by microscopy has precluded their routine use in monitoring or screening for cancer. We recently described a high-throughput microfluidic CTC-iChip, which efficiently depletes hematopoietic cells from blood specimens and enriches for CTCs with well-preserved RNA. Application of RNA-based digital PCR to detect CTC-derived signatures may thus enable highly accurate tissue lineage-based cancer detection in blood specimens...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28091728/value-of-nonrigid-registration-of-pre-procedure-mr-with-post-procedure-ct-after-radiofrequency-ablation-for-hepatocellular-carcinoma
#3
Juil Park, Jeong Min Lee, Dong Ho Lee, Ijin Joo, Jeong Hee Yoon, Jin Young Park, Ernst Klotz
PURPOSE: To evaluate the value of pre-radiofrequency ablation (RFA) MR and post-RFA CT registration for the assessment of the therapeutic response of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A total of 178 patients with single HCC who received RFA as an initial treatment and had available pre-RFA MR and post-RFA CT images were included in this retrospective study. Two independent readers (one experienced radiologist, one inexperienced radiologist) scored the ablative margin (AM) of treated tumors on a four-point scale (1, residual tumor; 2, incomplete AM; 3, borderline AM; 4, sufficient AM), in two separate sessions: (1) visual comparison between pre-and post-RFA images; (2) with addition of nonrigid registration for pre- and post-RFA images...
January 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28081589/preemptive-antiviral-therapy-with-entecavir-can-reduce-acute-deterioration-of-hepatic-function-following-transarterial-chemoembolization
#4
Sun Hong Yoo, Jeong Won Jang, Jung Hyun Kwon, Seung Min Jung, Bohyun Jang, Jong Young Choi
BACKGROUND/AIMS: Hepatic damage during transarterial chemoembolization (TACE) is a critical complication in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Apart from its role in preventing HBV reactivation, there is some evidence for the benefits of preemptive antiviral therapy in TACE. This study evaluated the effect of preemptive antiviral therapy on acute hepatic deterioration following TACE. METHODS: This retrospective observational study included a prospectively collected cohort of 108 patients with HBV-related HCC who underwent TACE between January 2007 and January 2013...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28081587/clinical-significance-and-predictive-factors-of-early-massive-recurrence-after-radiofrequency-ablation-in-patients-with-a-single-small-hepatocellular-carcinoma
#5
Ju-Yeon Cho, Moon Seok Choi, Gil Sun Lee, Won Sohn, Jemma Ahn, Dong-Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
BACKGROUND/AIMS: Radiofrequency ablation (RFA) is one of the most frequently applied curative treatments in patients with a single small hepatocellular carcinoma (HCC). However, the clinical significance of and risk factors for early massive recurrence after RFA-a dreadful event limiting further curative treatment-have not been fully evaluated. METHODS: In total, 438 patients with a single HCC of size ≤3 cm who underwent percutaneous RFA as an initial treatment between 2006 and 2009 were included...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28078526/effectiveness-and-safety-of-entecavir-or-tenofovir-in-a-spanish-cohort-of-chronic-hepatitis-b-patients-validation-of-the-page-b-score-to-predict-hepatocellular-carcinoma
#6
Mar Riveiro-Barciela, David Tabernero, José L Calleja, Sabela Lens, María L Manzano, Francisco Gea Rodríguez, Javier Crespo, Belén Piqueras, Juan M Pascasio, Carmen Comas, Maria L Gutierrez, Alberto Aguirre, Emilio Suárez, Javier García-Samaniego, Miguel Rivero, Doroteo Acero, Miguel Fernandez-Bermejo, Diego Moreno, Pilar Sánchez-Pobre, Beatriz de Cuenca, J J Moreno-Palomares, Rafael Esteban, Maria Buti
BACKGROUND: Long-term antiviral therapy has resulted in viral suppression and biochemical response in chronic hepatitis B, although the risk of hepatocellular carcinoma has not been abolished. The Page-B score could be useful to estimate the probability of HCC. AIMS: To analyze the effectiveness and safety of entecavir or tenofovir for more than 4 years and the usefulness of Page-B score in the real-world setting. METHODS: Analysis of Caucasian chronic hepatitis B subjects treated with entecavir or tenofovir from the prospective, multicenter database CIBERHEP...
January 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28060739/a-novel-micrornas-expression-signature-for-hepatocellular-carcinoma-diagnosis-and-prognosis
#7
Mengxuan Lu, Xia Kong, Huaigao Wang, Guoliang Huang, Caiguo Ye, Zhiwei He
This study aims to identify prognostic microRNAs (miRNAs) biomarkers for diagnosis and survival of hepatocellular carcinoma (HCC) based on large patients cohort analysis. HCC patient cohort data were downloaded from The Cancer Genome Atlas, including paired HCC and adjacent non-cancer tissues. Receiver operating characteristic curve method was used to classify cancer and non-cancer tissues according to microRNAs expression levels. The aberrant microRNAs expression level were ranked and risked for building a prognostic miRNAs signature model...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28036264/robust-transcriptional-tumor-signatures-applicable-to-both-formalin-fixed-paraffin-embedded-and-fresh-frozen-samples
#8
Rou Chen, Qingzhou Guan, Jun Cheng, Jun He, Huaping Liu, Hao Cai, Guini Hong, Jiahui Zhang, Na Li, Lu Ao, Zheng Guo
Formalin-fixed paraffin-embedded (FFPE) samples represent a valuable resource for clinical researches. However, FFPE samples are usually considered an unreliable source for gene expression analysis due to the partial RNA degradation. In this study, through comparing gene expression profiles between FFPE samples and paired fresh-frozen (FF) samples for three cancer types, we firstly showed that expression measurements of thousands of genes had at least two-fold change in FFPE samples compared with paired FF samples...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28033246/postsurgical-treatment-with-adjuvant-transarterial-chemoembolization-in-patients-with-hepatitis-b-related-hepatocellular-carcinoma-a-strobe-compliant-article
#9
Hao Hu, Rong Liu, Xiao Ran Long, Xi Kun Han, Jia Fan, Zhi Ping Yan, Jian Hua Wang
This study sought to develop a reliable and easy-to-use scoring model to guide the decision to perform postsurgical adjuvant transarterial chemoembolization (PA-TACE) in patients with hepatitis B-related hepatocellular carcinoma (HCC).The study included 235 consecutive patients with hepatitis B-related HCC undergoing PA-TACE at our medical center. Patients were assigned to 2 sets according to the PA-TACE date: initial (2005-2007; n = 130) and internal validation (2008-2009; n = 105) sets. With the aid of a Cox regression model, we developed a risk-scoring model from the independent predictive factors of our initial set designed as a guide for PA-TACE, and the performance of the model was validated with an internal set...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032575/liver-resection-versus-liver-resection-plus-tace-for-patients-with-hepatocellular-carcinoma-beyond-milan-criteria
#10
Chuan Li, Tian-Fu Wen, Lv-Nan Yan, Wu-Sheng Lu, Bo Li, Wen-Tao Wang, Ming-Qing Xu, Jia-Yin Yang
BACKGROUND: The recurrence of patients with hepatocellular carcinoma (HCC) beyond the Milan criteria after liver resection (LR) is common. This study aimed to clarify whether LR plus postoperative adjuvant transcatheter arterial chemoembolization (TACE) could improve the outcomes of patients with HCC beyond the Milan criteria after LR. METHODS: A total of 754 consecutive patients with HCC beyond the Milan criteria who received LR alone (n = 459) or LR + TACE (n = 295) were included...
October 4, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28029300/hospice-utilization-and-its-effect-on-acute-care-needs-at-the-end-of-life-in-medicare-beneficiaries-with-hepatocellular-carcinoma
#11
Hanna K Sanoff, YunKyung Chang, Melissa Reimers, Jennifer L Lund
INTRODUCTION: Hepatocellular carcinoma (HCC) is a poor-prognosis cancer with a high symptom burden. Multidisciplinary HCC care is complex and unique in cancer medicine. We sought to determine whether the distinct process affects hospice use and how hospice affects end-of-life acute care utilization. PATIENTS AND METHODS: Patients dying after HCC diagnosed from 2004 to 2011 were identified within SEER-Medicare. Hospice use and associated factors were described using logistic regression...
December 28, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28027753/liver-failure-after-hepatectomy-a-risk-assessment-using-the-pre-hepatectomy-shear-wave-elastography-technique
#12
Hong Han, Hao Hu, Ya Dan Xu, Wen Ping Wang, Hong Ding, Qing Lu
OBJECTIVE: To determine the efficacy of liver stiffness (LS) measurements utilizing the Shear Wave Elastography (SWE) technique for predicting post-hepatectomy liver failure (PHLF) among patients with hepatocellular carcinoma (HCC). METHODS: Data from eighty consecutive patients who were undergoing hepatectomy for HCC were prospectively identified and evaluated with preoperative SWE. The SWE was measured with advanced ultrasound equipment (Philips EPIQ7; Philips Healthcare, Seattle, WA, USA)...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28013117/hepatocellular-carcinoma-is-the-most-common-indication-for-liver-transplantation-and-placement-on-the-waitlist-in-the-united-states
#13
Ju Dong Yang, Joseph J Larson, Kymberly D Watt, Alina M Allen, Russell H Wiesner, Gregory J Gores, Lewis R Roberts, Julie A Heimbach, Michael D Leise
BACKGROUND & AIMS: Management strategies for patients with hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) have changed, along with liver allocation policies based on model for end-stage liver disease (MELD) score. We investigated etiologic-specific trends in liver transplantation in the United States (US) during different time periods. METHODS: We performed a retrospective study, using the United Network for Organ Sharing/ Organ Procurement and Transplantation Network registry data to identify all adult patients registered for liver transplantation in the US from January 1, 2004 through December 31, 2015...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28000517/anxiety-and-depression-are-associated-with-long-term-outcomes-of-hepatocellular-carcinoma-a-nationwide-study-of-a-taiwan-cohort
#14
King-Teh Lee, Jin-Jia Lin, Hon-Yi Shi
OBJECTIVE: A natural experimental design was coupled with propensity score matching to assess the risks of anxiety and depression and to assess the longitudinal effects of anxiety and depression on healthcare utilization and mortality in hepatocellular carcinoma (HCC) patients. METHODS: This nationwide population-based cohort study retrospectively analyzed 7,304 patients treated for HCC during 1996-2010. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of anxiety and depression disorders...
December 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27987016/factors-affecting-the-postoperative-morbidity-and-survival-of-patients-with-liver-cirrhosis-following-colorectal-cancer-surgery
#15
Jun Ho Lee, Chang Sik Yu, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
PURPOSE: Data are lacking on the appropriate risk stratification of patients undergoing surgery for colorectal cancer (CRC). This study aimed to evaluate the predictive factors for perioperative morbidity and oncological outcomes in CRC patients with liver cirrhosis (LC). METHODS: A retrospective analysis of prospectively collected data was conducted. A total of 161 LC patients who underwent surgery for CRC were identified between January 2001 and December 2010...
December 16, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27980231/a-novel-model-for-predicting-hepatocellular-carcinoma-development-in-patients-with-chronic-hepatitis-b-and-normal-alanine-aminotransferase-levels
#16
Dong Hyun Sinn, Jeong-Hoon Lee, Kyunga Kim, Joong Hyun Ahn, Ji Hyeon Lee, Jung Hee Kim, Dong Hyeon Lee, Jung-Hwan Yoon, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Background/Aims: Hepatocellular carcinoma (HCC) can develop in chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels. Therefore, methods that can stratify an individual's HCC risk are needed. Methods: A simple HCC risk score was developed from 971 patients with CHB who had elevated hepatitis B virus DNA levels (>2,000 IU/mL) with normal or mildly elevated ALT levels (<80 U/L). The score was validated from an independent cohort of 507 patients...
December 16, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27958245/epidemiology-and-clinical-features-of-patients-with-hepatocellular-carcinoma-at-a-tertiary-hospital-in-jeddah
#17
Y A Qari, M H Mosli
BACKGROUND: This study describes the epidemiology and clinical features of hepatocellular carcinoma (HCC), and it investigates any association between Child-Pugh's classification and HCC. MATERIALS AND METHODS: A retrospective chart review was performed for HCC cases diagnosed between 2008 and 2014 at King Abdulaziz University Hospital. We documented the age at cancer diagnosis, gender, occupation, ethnic origin, HCC etiology, Child-Pugh scores, tumor characteristics, alpha-fetoprotein (AFP), and alkaline phosphatase (ALP) levels at diagnosis, and treatment administered...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27939085/a-seer-database-analysis-of-the-survival-advantage-of-transarterial-chemoembolization-for-hepatocellular-carcinoma-an-underutilized-therapy
#18
Stephen H Gray, Jared A White, Peng Li, Meredith L Kilgore, David T Redden, Ahmed K Abdel Aal, Heather N Simpson, Brendan McGuire, Devin E Eckhoff, Derek A Dubay
PURPOSE: To measure transarterial chemoembolization utilization and survival benefit among patients with hepatocellular carcinoma (HCC) in the Surveillance, Epidemiology, and End Results (SEER) patient population. MATERIALS AND METHODS: A retrospective study identified 37,832 patients with HCC diagnosed between 1991 and 2011. Survival was estimated by Kaplan-Meier method and compared by log-rank test. Propensity-score matching was used to address an imbalance of covariates...
December 8, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27935871/decreased-expression-of-protocadherin-20-is-associated-with-poor-prognosis-in-hepatocellular-carcinoma
#19
Yanqin Wu, Shuhui Zheng, Jiayan Yao, Minrui Li, Guang Yang, Ning Zhang, Shenghong Zhang, Bihui Zhong
Recently, protocadherin 20 has been reported as a tumor suppressor gene in hepatocellular carcinoma (HCC); however, the prognostic value of protocadherin 20 in HCC remains unclear. Hence, the purpose of this study was to investigate the clinical and prognostic values of protocadherin 20 in HCC patients. The expression of protocadherin 20 was assessed by quantitative real-time polymerase chain reaction, western blot, and immunohistochemistry. Kaplan-Meier curves were created to calculate the overall survival of the patients, and Cox regression models were used to identify the risk factors associated with prognosis...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27930829/diabetes-hepatocellular-carcinoma-and-mortality-in-hepatitis-c-infected-patients-a-population-based-cohort-study
#20
Ting-Shuo Huang, Chih-Lang Lin, Yu-Chiau Shyu, Chau-Ting Yeh, Kung-Hao Liang, Chi-Chin Sun, Mu-Jie Lu, Rong-Nan Chien
BACKGROUND AND AIM: The effect of diabetes mellitus (DM) on the development of hepatocellular carcinoma (HCC) and all-cause mortality after HCC development in chronic hepatitis C virus (HCV) infected patients remains inconclusive. This cohort study aimed to investigate these issues using the Taiwanese National Health Insurance Research Database. METHODS: We retrieved and enrolled newly diagnosed DM patients with HCV from the Longitudinal Cohort of Diabetes Patients database...
December 8, 2016: Journal of Gastroenterology and Hepatology
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