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https://www.readbyqxmd.com/read/29777455/combined-preoperative-albi-and-fib-4-is-associated-with-recurrence-of-hepatocellular-carcinoma-after-curative-hepatectomy
#1
Rui Liao, De-Wei Li, Cheng-You Du, Ming Li
BACKGROUND AND PURPOSE: Chronic inflammatory response is a risk factor for hepatocarcinogenesis and recurrence. This study aimed to develop a nomogram incorporating the combined albumin-bilirubin (ALBI) and fibrosis-4 (FIB-4) scores and the peritumoral inflammation score (PIS) to predict postoperative recurrence-free survival (RFS) of hepatocellular carcinoma (HCC). METHODS: The prognostic roles of preoperative ALBI and FIB-4 scores for HCC recurrence were investigated, and a nomogram was developed...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29761859/systematic-analyses-of-a-novel-lncrna-associated-signature-as-the-prognostic-biomarker-for-hepatocellular-carcinoma
#2
Jing Sui, Yan Miao, Jiali Han, Hongmei Nan, Bo Shen, Xiaomei Zhang, Yan Zhang, Yuan Wu, Wenjuan Wu, Tong Liu, Siyi Xu, Sheng Yang, Lihong Yin, Yuepu Pu, Geyu Liang
Accumulating evidence implies that long noncoding RNAs (lncRNAs) play a crucial role in predicting survival for Hepatocellular carcinoma (HCC) patients. This study aims to capture the current research hotspots of HCC, based on the analysis of publications related to HCC research from 2013 to 2017, and to identify a novel lncRNA signature for HCC prognosis through the data mining in The Cancer Genome Atlas (TCGA). "Prognosis" and "biomarker" were located in the core of the HCC research hotspot...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29753085/effects-of-virologic-response-to-treatment-on-short-and-long-term-outcomes-of-patients-with-chronic-hbv-infection-and-decompensated-cirrhosis
#3
Jeong Won Jang, Jong Young Choi, Young Seok Kim, Jeong-Ju Yoo, Hyun Young Woo, Sung Kyu Choi, Chung Hwan Jun, Chang Hyeong Lee, Joo Hyun Sohn, Won Young Tak, Yu Rim Lee, Kwang-Hyub Han
BACKGROUND & AIMS: Little is known about the effects of antiviral therapy on short- and long-term survival of patients with hepatitis B virus (HBV)-related decompensated cirrhosis. We aimed to determine whether a maintained virologic response (MVR, defined as persistent undetectable HBV DNA during therapy) associates with short-term (6-month) and long-term (6-120 months) survival of patients with decompensated cirrhosis. METHODS: We performed a 10-year observation analysis using data from the Epidemiology and Natural History of Liver Cirrhosis study of patients with decompensated liver cirrhosis in Korea...
May 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29750389/delisting-hcv-infected-liver-transplant-candidates-who-improved-after-viral-eradication-outcome-2-years-after-delisting
#4
Giovanni Perricone, Christophe Duvoux, Marina Berenguer, Paolo A Cortesi, Carmen Vinaixa, Rita Facchetti, Chiara Mazzarelli, Susanne Rasoul-Rockenschaub, Silvia Martini, Cristina Morelli, Sara Monico, Riccardo Volpes, Georges-Philippe Pageaux, Stefano Fagiuoli, Luca S Belli
BACKGROUNDS AND AIMS: Treating patients with decompensated cirrhosis with direct-acting antiviral (DAA) therapy while on the waiting list for liver transplantation, results in substantial improvement of liver function allowing one in four patients to be removed from the waiting list or delisted, as reported in a previous study promoted by the European Liver and Intestine Transplant Association (ELITA). Aim of this study was to report on clinical outcomes of delisted patients, including mortality risk, hepatocellular-carcinoma development, and clinical de-compensation requiring relisting...
May 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29750037/simple-score-to-predict-risk-of-hepatocellular-carcinoma-in-chronic-hepatitis-c-patients-with-advanced-fibrosis-after-pegylated-interferon-and-ribavirin-therapy
#5
Ching-Chih Hu, Cheng-Hao Weng, Liang-Che Chang, Chih-Lang Lin, Yen-Ting Chen, Ching-Fang Hu, Man-Chin Hua, Li-Wei Chen, Rong-Nan Chien
Purpose: Eradication of chronic hepatitis C virus (HCV) after interferon-based therapy and its association with the reduction of risk of hepatocellular carcinoma (HCC) in HCV-infected patients with advanced fibrosis is controversial. The study is aimed to develop a simple scoring model for HCC prediction among advanced fibrotic chronic hepatitis C (CHC) patients after pegylated interferon (pegIFN) and ribavirin (RBV) therapy. Patients and methods: We enrolled 271 biopsy-proven CHC patients with advanced fibrosis between 2003 and 2016, and divided them into non-HCC (n=211) and HCC (n=60) groups...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29745475/metabolic-disorders-across-hepatocellular-carcinoma-in-italy
#6
Filomena Morisco, Maria Guarino, Maria Rosa Valvano, Francesco Auriemma, Fabio Farinati, Edoardo G Giannini, Francesca Ciccarese, Francesco Tovoli, Gian Ludovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Rodolfo Sacco, Giuseppe Cabibbo, Martina Felder, Luisa Benvengù, Antonio Gasbarrini, Gianluca Svegliati Baroni, Francesco Giuseppe Foschi, Elisabetta Biasini, Alberto Masotto, Roberto Virdone, Fabio Marra, Nicola Caporaso, Franco Trevisani
BACKGROUND: Metabolic disorders are well known risk factors for HCC. Conversely, their impact on the natural history of HCC is not established. This study aimed at evaluating the impact of metabolic disorders on clinical features, treatment and survival of HCC patients regardless of its etiology. METHODS: We analyzed the ITA.LI.CA database regarding 839 HCC patients prospectively collected. The following metabolic features were analyzed: BMI, diabetes, arterial hypertension, hypercholesterolemia and hypertriglyceridemia...
May 10, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29736828/the-impact-of-tumor-differentiation-on-the-prognosis-of-hbv-associated-solitary-hepatocellular-carcinoma-following-hepatectomy-a-propensity-score-matching-analysis
#7
Junyi Shen, Jiaye Liu, Chuan Li, Tianfu Wen, Lvnan Yan, Jiayin Yang
AIM: The role of tumor differentiation in the prognosis of hepatocellular carcinoma (HCC) after hepatectomy remains controversial. The present study aimed to classify the impact of tumor differentiation on solitary hepatitis B viral (HBV)-associated HCC using propensity score matching analysis. METHODS: Between January 2009 and March 2015, the data of 721 HCC patients in West China Hospital were prospectively collected and analyzed. Propensity matching analysis was applied to overcome the imbalance in baseline characteristics...
May 7, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29733831/fibrosis-severity-as-a-determinant-of-cause-specific-mortality-in-patients-with-advanced-nonalcoholic-fatty-liver-disease
#8
Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Vincent Wai-Sun Wong, Marlen Castellanos, Rocio Aller-de la Fuente, Mayada Metwally, Mohammed Eslam, Licet Gonzalez-Fabian, María Alvarez-Quiñones Sanz, Antonio Felix Conde-Martin, Bastiaan De Boer, Duncan McLeod, Anthony Wing Hung Chan, Naga Chalasani, Jacob George, Leon A Adams, Manuel Romero-Gomez
BACKGROUND & AIMS: Little is known about the natural course of nonalcoholic fatty liver disease (NAFLD) with advanced fibrosis. We describe long-term outcomes and evaluate the effects of clinical and histologic parameters on disease progression in patients with advanced NAFLD. METHODS: We conducted a multi-national study of 458 patients with biopsy-confirmed NAFLD with bridging fibrosis (F3, n=159) or compensated cirrhosis (222 patients with Child-Turcotte-Pugh [CTP] scores of A5 and 77 patients with scores of A6), evaluated from April 1995 through November 2013 and followed until December 2016, death, or liver transplantation at hepatology centers in Spain, Australia, Hong Kong, and Cuba...
May 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29730905/assessment-of-the-surveillance-interval-at-1-year-after-curative-treatment-in-hepatocellular-carcinoma-risk-stratification
#9
Minjong Lee, Young Chang, Sohee Oh, Young Youn Cho, Dhong-Eun Jung, Hong Hyun Kim, Joon Yeul Nam, Hyeki Cho, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Nam-Joon Yi, Kwang-Woong Lee, Dong Ho Lee, Jeong Min Lee, Jung-Hwan Yoon, Kyung-Suk Suh, Yoonjun Kim
Background/Aims: Guidelines recommend surveillance for hepatocellular carcinoma (HCC) recurrence at 3-month intervals during the first year after curative treatment and 6-month intervals thereafter in all patients. This strategy does not reflect individual risk of recurrence. We aimed to stratify risk of recurrence to optimize surveillance intervals during the first year after treatment. Methods: We retrospectively analyzed 1,316 HCC patients treated with resection/radiofrequency ablation at Barcelona Clinic Liver Cancer stage 0/A...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29728879/postoperative-adjuvant-trans-arterial-chemoembolization-for-patients-with-hepatocellular-carcinoma-and-portal-vein-tumor-thrombus
#10
Shuang Liu, Lei Guo, Hui Li, Bo Zhang, Jialei Sun, Chenghao Zhou, Jian Zhou, Jia Fan, Qinghai Ye
BACKGROUND: It remains uncertain whether patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) benefit from postoperative adjuvant trans-arterial chemoembolization (PA-TACE). METHODS: We retrospectively identified 540 patients to form the crude cohort and adopted propensity score matching analysis to assemble another cohort of 464 patients with similar baseline characteristics. Univariate and multivariate Cox analyses were performed in exploratory subgroups to identify the independent effect of PA-TACE on overall survival (OS)...
May 4, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29713196/identification-of-potential-prognostic-microrna-biomarkers-for-predicting-survival-in-patients-with-hepatocellular-carcinoma
#11
Xiwen Liao, Guangzhi Zhu, Rui Huang, Chengkun Yang, Xiangkun Wang, Ketuan Huang, Tingdong Yu, Chuangye Han, Hao Su, Tao Peng
Background: The aim of the present study was to identify potential prognostic microRNA (miRNA) biomarkers for hepatocellular carcinoma (HCC) prognosis prediction based on a dataset from The Cancer Genome Atlas (TCGA). Materials and methods: A miRNA sequencing dataset and corresponding clinical parameters of HCC were obtained from TCGA. Genome-wide univariate Cox regression analysis was used to screen prognostic differentially expressed miRNAs (DEMs), and multivariable Cox regression analysis was used for prognostic signature construction...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29672883/assessment-of-advanced-liver-fibrosis-and-the-risk-for-hepatic-decompensation-in-patients-with-congestive-hepatopathy
#12
REVIEW
Alexander Lemmer, Lisa B Van-Wagner, Daniel Ganger
Congestive hepatopathy (CH) arises from chronically elevated right sided heart pressures transmitted to the liver by passive venous congestion. Over time CH can lead to hepatic bridging fibrosis, decompensated cirrhosis, and hepatocellular carcinoma. Currently there are no evidence-based guidelines to direct appropriate screening or management of patients with CH partly because of the inability of current clinical tools (serum tests, imaging studies, liver stiffness measurements, and liver biopsy) to accurately estimate hepatic fibrosis or the risk for hepatic decompensation...
April 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29660216/the-prognostic-significance-of-serum-hbeag-on-the-recurrence-and-long-term-survival-after-hepatectomy-for-hepatocellular-carcinoma-a-propensity-score-matching-analysis
#13
Junyi Shen, Jiaye Liu, Chuan Li, Tianfu Wen, Lvnan Yan, Jiayin Yang
The effects of serum hepatitis B e antigen (HBeAg) on the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy remain controversial. Our aim was to explore the prognostic significance of serum HBeAg on the prognosis of HCC patients using a propensity matching model. Between January 2009 and March 2015, 953 patients with HCC who underwent hepatectomy in West China Hospital were analyzed. Propensity matching analysis was applied and survival analysis was performed using the Kaplan-Meier method...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29649017/a-point-based-histologic-scoring-system-for-hepatocellular-carcinoma-can-stratify-risk-of-posttransplant-tumor-recurrence
#14
Daniel E Roberts, Sanjay Kakar, Neil Mehta, Ryan M Gill
Eligibility for liver transplant is most commonly decided by measuring tumor size and number on radiographic imaging. However, this method often underestimates the extent of disease. Evaluation of tumor histology has been shown to improve risk stratification when compared with imaging-based transplant criteria, but the World Health Organization (WHO) guidelines for grading hepatocellular carcinoma (HCC) are imprecise and require subjective interpretation by the pathologist. We performed a retrospective analysis of 190 explanted livers containing HCC and correlated histologic features with posttransplant recurrence to formulate a three-tiered, point-based scoring system that categorizes tumors as having a low, intermediate, or high risk of recurrence...
April 11, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29623506/considerations-when-treating-hepatitis-c-in-a-cirrhotic-transplant-candidate
#15
REVIEW
Kimberly E Daniel, Adnan Said
PURPOSE OF REVIEW: This review examines the issues in determining the decision to treat a HCV-positive patient who is a liver transplant (LT) candidate with highly effective and well-tolerated direct-acting antiviral (DAA) therapies. RECENT FINDINGS: Cure of HCV with DAA can improve liver function and allow delisting in some patients. Beyond a threshold of hepatic impairment (likely MELD score > 16 to 20), patients may experience a decline in MELD score with HCV cure without improvement in liver-related complications resulting in decreased opportunity to receive a LT...
April 5, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29621282/predictive-value-of-the-preoperative-neutrophil-to-lymphocyte-ratio-for-the-development-of-hepatocellular-carcinoma-in-hbv-associated-cirrhotic-patients-after-splenectomy
#16
Zhaoqing Du, Jian Dong, Jianbin Bi, Ruhai Bai, Jia Zhang, Zheng Wu, Yi Lv, Xufeng Zhang, Rongqian Wu
The neutrophil to lymphocyte ratio (NLR), a simple marker of inflammation, has recently been showed to predict tumor recurrence in hepatocellular carcinoma (HCC) patients after hepatic resection or liver transplantation. However, whether it can be used to predict HCC development in cirrhotic patients remained unknown. The aim of this study was to evaluate the predictive value of the preoperative NLR for the development of HCC in cirrhotic patients who underwent splenectomy. A total of 230 HBV-associated cirrhotic patients who underwent splenectomy in our hospital from January 2000 to December 2012 were included in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29608544/treatment-optimization-for-hepatocellular-carcinoma-in-elderly-patients-in-a-japanese-nationwide-cohort
#17
Masaki Kaibori, Kengo Yoshii, Kiyoshi Hasegawa, Asao Ogawa, Shoji Kubo, Ryosuke Tateishi, Namiki Izumi, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Tadatoshi Takayama, Norihiro Kokudo
OBJECTIVE: We reviewed nationwide follow-up data to determine outcomes of different treatments for early-stage hepatocellular carcinoma (HCC) in elderly patients. SUMMARY BACKGROUND DATA: Outcomes of early-stage HCC treatments in elderly patients have not been prospectively compared. METHODS: We included 6490 HCC patients, aged ≥75 years at treatment, who underwent curative hepatic resection (HR, n = 2020), radiofrequency ablation (RFA, n = 1888), microwave ablation (MWA, n = 193), or transcatheter arterial chemoembolization (TACE, n = 2389), and compared their characteristics and survival...
March 30, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29604231/reframing-the-approach-to-patients-with-hepatocellular-carcinoma-longitudinal-assessment-with-halthcc-improves-ablate-and-wait-strategy
#18
Daniel J Firl, Shoko Kimura, John McVey, Koji Hashimoto, Heidi Yeh, Charles M Miller, James F Markmann, Kazunari Sasaki, Federico N Aucejo
Patients with hepatocellular carcinoma (HCC) are screened at presentation for appropriateness of liver transplantation (LT) using morphometric criteria, which poorly specifies risk. Morphology is the crux of measuring tumor response to locoregional therapy (LRT) using modified response evaluation criteria in solid tumors (mRECIST). This study investigated the utility of following a continuous risk score (hazard associated with liver transplantation in HCC [HALTHCC]) to longitudinally assess risk. This multicenter retrospective study from 2002-2014 enrolled 419 patients listed for LT for HCC...
March 31, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29604220/liver-angiopoietin-2-is-a-key-predictor-of-de-novo-or-recurrent-hepatocellular-cancer-after-hcv-direct-acting-antivirals
#19
Francesca Faillaci, Luca Marzi, Rosina Critelli, Fabiola Milosa, Filippo Schepis, Elena Turola, Silvia Andreani, Gabriele Vandelli, Veronica Bernabucci, Barbara Lei, Federica D'Ambrosio, Laura Bristot, Luisa Cavalletto, Liliana Chemello, Pamela Sighinolfi, Paola Manni, Antonino Maiorana, Cristian Caporali, Marcello Bianchini, Maria Marsico, Laura Turco, Nicola de Maria, Mariagrazia Del Buono, Paola Todesca, Luca di Lena, Dante Romagnoli, Paolo Magistri, Fabrizio di Benedetto, Savino Bruno, Gloria Taliani, Gianluigi Giannelli, Maria-Luz Martinez-Chantar, Erica Villa
Recent reports suggested that direct acting antivirals (DAAs) might favor hepatocellular carcinoma (HCC).In Study 1,we studied the proangiogenic liver microenvironment in 242 DAAs-treated chronic Hepatitis C patients with advanced fibrosis.Angiopoietin-2 expression was studied in tissue (cirrhotic and/or neoplastic) from recurrent,de novo,non-recurrent HCC or patients never developing HCC.Circulating Angiopoietin-2,vascular-endothelial growth factor (VEGF),and C-reactive protein were also measured. In Study 2,we searched for factors associated with de novo HCC in 257 patients with cirrhosis of different etiologies enrolled in a dedicated prospective study...
March 31, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29599368/metformin-associated-chemopreventive-effects-on-recurrence-after-hepatic-resection-of-hepatocellular-carcinoma-from-in-vitro-to-a-clinical-study
#20
Woo-Hyoung Kang, Eunyoung Tak, Shin Hwang, Gi-Won Song, Eunkyoung Jwa, Young-Joo Lee, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Dong-Hwan Jung, Gil-Chun Park, Kyoung-Jin Lee, Nayoung Kim, Sung-Gyu Lee
BACKGROUND/AIM: We investigated metformin-induced cytotoxic effects in vitro and assessed the chemopreventive effects of metformin in patients undergoing hepatic resection (HR) for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This study consisted of laboratory and clinical studies. RESULTS: In vitro study using HCC cell lines revealed noticeable cytotoxic effects of metformin, that were largely weaker than those of sorafenib. In the clinical study, no statistical differences were found in tumor recurrence or overall survival between metformin and control groups...
April 2018: Anticancer Research
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