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https://www.readbyqxmd.com/read/27905953/improving-the-usefulness-of-us-mortality-data-new-methods-for-reclassification-of-underlying-cause-of-death
#1
Kyle J Foreman, Mohsen Naghavi, Majid Ezzati
BACKGROUND: Mortality data are affected by miscertification of the medical cause of death deaths and changes to cause of death classification systems. We present both mappings of ICD9 and ICD10 to a unified list of causes, and a new statistical model for reducing the impact of misclassification of cause of death. METHODS: We propose a Bayesian mixed-effects multinomial logistic model that can be run on individual record level death certificates to reclassify "garbage-coded" deaths onto causes that are more meaningful for public health purposes...
April 28, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#2
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27813318/bleeding-and-liver-transplantation-outcomes-in-haemophilia
#3
K D Mehta, M V Ragni
BACKGROUND: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia. AIM: To assess the epidemiology and outcomes of OLTx in U.S. haemophilia patients. METHODS: We investigated haemophilia liver transplant recipients between 1993 and 2012, using the Nationwide Inpatient Sample, identified by ICD9 code 50.59. RESULTS: Of the 11 267 (weighted n = 54 691) patients undergoing OLTx, 44 (0...
November 4, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27804171/development-and-validation-of-case-finding-algorithms-for-the-identification-of-patients-with-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-in-large-healthcare-administrative-databases
#4
Antoine G Sreih, Narender Annapureddy, Jason Springer, George Casey, Kevin Byram, Andy Cruz, Maya Estephan, Vince Frangiosa, Michael D George, Mei Liu, Adam Parker, Sapna Sangani, Rebecca Sharim, Peter A Merkel
PURPOSE: The aim of this study was to develop and validate case-finding algorithms for granulomatosis with polyangiitis (Wegener's, GPA), microscopic polyangiitis (MPA), and eosinophilic GPA (Churg-Strauss, EGPA). METHODS: Two hundred fifty patients per disease were randomly selected from two large healthcare systems using the International Classification of Diseases version 9 (ICD9) codes for GPA/EGPA (446.4) and MPA (446.0). Sixteen case-finding algorithms were constructed using a combination of ICD9 code, encounter type (inpatient or outpatient), physician specialty, use of immunosuppressive medications, and the anti-neutrophil cytoplasmic antibody type...
December 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27795870/national-trends-in-inpatient-admissions-following-stereotactic-radiosurgery-and-the-in-hospital-patient-outcomes-in-the-united-states-from-1998-to-2011
#5
Allen L Ho, Alexander Y Li, Eric S Sussman, Arjun V Pendharkar, Aditya Iyer, Patricia A Thompson, Armine T Tayag, Steven D Chang
PURPOSE: This study sought to examine trends in stereotactic radiosurgery (SRS) and in-hospital patient outcomes on a national level by utilizing national administrative data from the Nationwide Inpatient Sample (NIS) database. METHODS AND MATERIALS: Using the NIS database, all discharges where patients underwent inpatient SRS were included in our study from 1998 - 2011 as designated by the ICD9-CM procedural codes. Trends in the utilization of primary and adjuvant SRS, in-hospital complications and mortality, and resource utilization were identified and analyzed...
2016: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/27783343/outcomes-after-surgery-for-benign-and-malignant-small-bowel-obstruction
#6
Lauren M Wancata, Zaid M Abdelsattar, Pasithorn A Suwanabol, Darrell A Campbell, Samantha Hendren
BACKGROUND: Small bowel obstruction (SBO) is a common diagnosis; however, outcomes of and risk factors for SBO and malignant bowel obstruction (MBO) surgery are not well understood. We sought to characterize outcomes and risk factors for surgery for SBO and MBO. METHODS: A retrospective cohort study was performed utilizing prospectively collected data from the Michigan Surgical Quality Collaborative (7/2012-3/2015). Cases included those with ICD9 diagnosis code of bowel obstruction and CPT codes for lysis of adhesions, intestinal bypass, and small bowel resection...
October 25, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27764223/academic-outcomes-in-high-school-students-after-a-concussion-a-retrospective-population-based-analysis
#7
Kelly Russell, Michael G Hutchison, Erin Selci, Jeff Leiter, Daniel Chateau, Michael J Ellis
BACKGROUND: Many concussion symptoms, such as headaches, vision problems, or difficulty remembering or concentrating may deleteriously affect school functioning. Our objective was to determine if academic performance was lower in the academic calendar year that students sustain a concussion compared to the previous year when they did not sustain a concussion. METHODS: Using Manitoba Health and Manitoba Education data, we conducted a population-based, controlled before-after study from 2005-2006 to 2010-2011 academic years...
2016: PloS One
https://www.readbyqxmd.com/read/27748040/maternal-factors-and-the-risk-of-birth-defects-after-ivf-and-icsi-a-whole-of-population-cohort-study
#8
M J Davies, A R Rumbold, J L Marino, K Willson, L C Giles, M J Whitrow, W Scheil, L J Moran, J G Thompson, M Lane, V M Moore
OBJECTIVE: To assess the contribution of maternal factors to major birth defects after in vitro fertilisation (IVF), intracytoplasmic sperm injection (ICSI), and natural conception. DESIGN: Retrospective cohort study in South Australia for the period January 1986 to December 2002. SETTING: A whole of population study. POPULATION: A census of all IVF and ICSI linked to registries for births, pregnancy terminations, and birth defects (diagnosed before a child's fifth birthday)...
October 17, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27747521/the-burden-of-rheumatic-diseases-an-analysis-of-an-italian-administrative-database
#9
Sergio Iannazzo, Gianluca Furneri, Federica Demma, Chiara Distante, Simone Parisi, Veronica Berti, Enrico Fusaro
INTRODUCTION: Chronic inflammatory rheumatic diseases (RDs) trigger high costs for healthcare systems and society due to the disability and comorbidity associated with these disease entities. The aim of this study was to analyze patients with RD, assess the use of conventional synthetic and biologic therapies, and estimate the overall cost of treatment in Italy. METHODS: Administrative healthcare claims from the Piedmont region in Northwest Italy were reviewed to identify patients who received disease-modifying antirheumatic drugs (DMARDs) between 2007 and 2010...
June 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27716355/use-of-explicit-icd9-cm-codes-to-identify-adult-severe-sepsis-impacts-on-epidemiological-estimates
#10
C Bouza, T Lopez-Cuadrado, J M Amate-Blanco
BACKGROUND: Severe sepsis is a challenge for healthcare systems, and epidemiological studies are essential to assess its burden and trends. However, there is no consensus on which coding strategy should be used to reliably identify severe sepsis. This study assesses the use of explicit codes to define severe sepsis and the impacts of this on the incidence and in-hospital mortality rates. METHODS: We examined episodes of severe sepsis in adults aged ≥18 years registered in the 2006-2011 national hospital discharge database, identified in an exclusive manner by two ICD-9-CM coding strategies: (1) those assigned explicit ICD-9-CM codes (995...
October 3, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27637187/predicting-30-day-postoperative-mortality-for-emergent-anterior-abdominal-wall-hernia-repairs-using-the-american-college-of-surgeons-national-surgical-quality-improvement-program-database
#11
P J Chung, J S Lee, S Tam, A Schwartzman, M O Bernstein, L Dresner, A Alfonso, G Sugiyama
PURPOSE: Anterior abdominal wall hernias are among the most commonly encountered surgical disease. We sought to identify risk factors that are associated with 30-day postoperative mortality following emergent abdominal wall hernia repair using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. METHODS: A retrospective analysis of data from the ACS NSQIP from 2005 to 2010 was performed. Patients were selected using Current Procedural Terminology (CPT) and International Classification of Disease 9 Clinical Modification (ICD9) codes for the repair of inguinal, femoral, umbilical, epigastric, ventral, or incisional hernias that were incarcerated, obstructed, strangulated, or gangrenous...
September 16, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27632266/the-possible-role-of-dental-implants-in-the-etiology-and-prognosis-of-osteomyelitis-a-retrospective-study
#12
Ran Yahalom, Yasmine Ghantous, Avi Peretz, Imad Abu-Elnaaj
PURPOSE: The aim of this study was to describe the clinical outcome of osteomyelitis of the mandible or maxilla following dental implants. A detailed treatment protocol is also proposed. MATERIALS AND METHODS: Electronic data of all the patients who were treated between October 2009 and November 2014, in three maxillofacial surgical departments, were reviewed. Computed databases were searched for the diagnosis of osteomyelitis of the mandible or maxillas (ICD9 code 526...
September 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27621953/intrapartum-cervical-laceration-and-subsequent-pregnancy-outcomes
#13
Luchin F Wong, Jacob Wilkes, Kent Korgenski, Michael W Varner, Tracy A Manuck
OBJECTIVE: The objective of this study was to describe pregnancy outcomes, including cervical insufficiency and preterm birth, in the subsequent pregnancy following an intrapartum cervical laceration. STUDY DESIGN: Retrospective cohort of women with their first two consecutive singleton pregnancies carried to ≥ 20(0/7) weeks' gestation within a tertiary health care system from 2002 to 2012. Cervical laceration cases were identified by ICD9 codes and included if suture repair was required...
July 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27584679/the-association-between-adjuvant-pain-medication-use-and-outcomes-following-pediatric-spinal-fusion
#14
Rebecca E Rosenberg, Stacey Trzcinski, Mindy Cohen, Mark Erickson, Thomas Errico, Lisa McLeod
STUDY DESIGN: Comparative effectiveness database study. OBJECTIVE: To describe variation in use of adjuvant therapies for managing postoperative pain in in patients undergoing posterior spinal fusion (PSF) for adolescent idiopathic (AIS) and determine association between use of these therapies and patient outcomes. SUMMARY OF BACKGROUND DATA: Variation in postoperative pain management for children undergoing PSF for AIS likely impacts outcomes...
August 31, 2016: Spine
https://www.readbyqxmd.com/read/27570647/learning-low-dimensional-representations-of-medical-concepts
#15
Youngduck Choi, Chill Yi-I Chiu, David Sontag
We show how to learn low-dimensional representations (embeddings) of a wide range of concepts in medicine, including diseases (e.g., ICD9 codes), medications, procedures, and laboratory tests. We expect that these embeddings will be useful across medical informatics for tasks such as cohort selection and patient summarization. These embeddings are learned using a technique called neural language modeling from the natural language processing community. However, rather than learning the embeddings solely from text, we show how to learn the embeddings from claims data, which is widely available both to providers and to payers...
2016: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/27545515/septal-ablation-and-hypertrophic-obstructive-cardiomyopathy-7-years-us-experience
#16
Ankit Chothani, Sidakpal S Panaich, Nilay Patel, Nileshkumar J Patel, Shilpkumar Arora, Abhishek Deshmukh, Cindy Grines, Apurva O Badheka
BACKGROUND: Septal ablation (SA) is a key modality for left ventricular outflow tract gradient reduction in hypertrophic obstructive cardiomyopathy (HOCM) patients with refractory symptoms. The primary objective of our study was to evaluate post-procedural mortality, complications, length of stay (LOS), and cost of hospitalization following SA. METHODS: We queried the Nationwide Inpatient Sample (NIS) between 2005 and 2011 using the ICD9 procedure code of 37.34 for ablation of heart tissue...
October 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27533304/risk-factors-of-131-i-induced-salivary-gland-damage-in-thyroid-cancer-patients
#17
Brynn Hollingsworth, Leigha Senter, Xiaoli Zhang, Guy N Brock, Wael Jarjour, Rebecca Nagy, Pamela Brock, Kevin R Coombes, Richard T Kloos, Matthew D Ringel, Jennifer Sipos, Ilene Lattimer, Ricardo Carrau, Sissy M Jhiang
CONTEXT: Sialadenitis and xerostomia are major adverse effects of (131)I therapy in thyroid cancer patients. The risk factors for these adverse effects, other than administered activity of (131)I, have not been investigated. OBJECTIVE: The aim of this study is to identify risk factors for (131)I-induced salivary gland damage among follicular cell-derived thyroid cancer patients. DESIGN: We enrolled 216 thyroid cancer patients who visited The Ohio State University Wexner Medical Center between April 2013 and April 2014...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27521990/effect-of-linezolid-on-hematologic-recovery-in-newly-diagnosed-acute-myeloid-leukemia-patients-following-induction-chemotherapy
#18
Adrienne N Nedved, Sean R DeFrates, Lindsay M Hladnik, Keith E Stockerl-Goldstein
OBJECTIVE: Assess the effects of linezolid on hematologic outcomes in newly diagnosed patients with acute myeloid leukemia (AML) following induction chemotherapy. DESIGN: Single-center, retrospective, observational, cohort study. SETTING: Large, tertiary care academic medical center. PATIENTS: A total of 225 patients ≥ 18 years admitted between December 2010 and 2013 with newly diagnosed AML were assessed for inclusion...
October 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27497800/evaluating-electronic-health-record-data-sources-and-algorithmic-approaches-to-identify-hypertensive-individuals
#19
Pedro L Teixeira, Wei-Qi Wei, Robert M Cronin, Huan Mo, Jacob P VanHouten, Robert J Carroll, Eric LaRose, Lisa A Bastarache, S Trent Rosenbloom, Todd L Edwards, Dan M Roden, Thomas A Lasko, Richard A Dart, Anne M Nikolai, Peggy L Peissig, Joshua C Denny
OBJECTIVE: Phenotyping algorithms applied to electronic health record (EHR) data enable investigators to identify large cohorts for clinical and genomic research. Algorithm development is often iterative, depends on fallible investigator intuition, and is time- and labor-intensive. We developed and evaluated 4 types of phenotyping algorithms and categories of EHR information to identify hypertensive individuals and controls and provide a portable module for implementation at other sites...
August 7, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27472792/differential-experience-with-men-s-and-women-s-health-care-visits-between-male-and-female-family-medicine-residents
#20
Gregory M Garrison, Natalie Gentile, Benjamin Lai, Kurt B Angstman, Robert Bonacci
BACKGROUND AND OBJECTIVES: Few studies have addressed whether male family medicine residents have more exposure to men's health issues than their female colleagues. Additionally, the association between panel demographics or continuity of care and the differential experience with gender-specific health care is unclear. METHODS: Between July 1, 2011, and June 30, 2014, all residents in the family medicine program had their gender, the number of women's and men's health care visits, the total number of male and female visits, and the number of visits with patients assigned to their primary care panel recorded each academic year...
July 2016: Family Medicine
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