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https://www.readbyqxmd.com/read/28922704/direct-acting-antivirals-for-chronic-hepatitis-c
#1
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g. sofosbuvir, are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). Sustained virological response (SVR) is used by investigators and regulatory agencies as a surrogate outcome for morbidity and mortality, based solely on observational evidence...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922571/interprofessional-oral-health-initiative-in-a-nondental-american-indian-setting
#2
Kate L Murphy, Laura S Larsson
BACKGROUND AND PURPOSE: Tooth decay is the most common chronic childhood disease and American Indian (AI) children are at increased risk. Pediatric primary care providers are in an opportune position to reduce tooth decay. The purpose of this study was to integrate and evaluate a pediatric oral health project in an AI, pediatric primary care setting. METHODS: The intervention set included caregiver education, caries risk assessment, and a same-day dental home referral...
September 18, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28922063/individual-calibration-of-accelerometers-in-children-and-their-health-related-implications
#3
Lynne M Boddy, Conor Cunningham, Stuart J Fairclough, Marie H Murphy, Gavin Breslin, Lawrence Foweather, Rebecca M Dagger, Lee E F Graves, Nicola D Hopkins, Gareth Stratton
This study compared children's physical activity (PA) levels, the prevalence of children meeting current guidelines of ≥60 minutes of daily moderate to vigorous PA (MVPA), and PA-health associations using individually calibrated (IC) and empirical accelerometer cutpoints. Data from 75 (n = 32 boys) 10-12 year old children were included in this study. Clustered cardiometabolic (CM) risk, directly measured cardiorespiratory fitness (CRF), anthropometric and 7 day accelerometer data were included within analysis...
September 18, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28922040/professional-generational-and-gender-differences-in-perception-of-organisational-values-among-israeli-physicians-and-nurses-implications-for-retention
#4
Sigalit Warshawski, Sivia Barnoy, Ilya Kagan
The global health workforce today is more age diverse than ever before and spans three generations: baby boomers, X and Y generations. Each generation has a distinct set of characteristics, values, and beliefs. This diversity can lead to increased creativity and a greater richness of values and skills, but at the same time it can also lead to value clashes, disrespect, and conflicts. This study aimed to examine professional, generational, and gender differences in the perception of the importance of organisational values among nurses and physicians working in both hospitals and outpatient clinics in Israel...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28919912/the-isfahan-comprehensive-elderly-study-objectives-research-design-methodology-and-preliminary-results
#5
Zahra Heidari, Awat Feizi
BACKGROUND: This paper presents the objectives, research design, methodology, and primary findings of the Isfahan Comprehensive Elderly Study (ICES). MATERIALS AND METHODS: In this cross-sectional study, 603 elderly persons (aged 60 and over) were selected by multistage cluster sampling method from Isfahan, Iran, in 2016 comprehensive questionnaires along with a detailed interview were used to collect information on personal, family, socioeconomic, health and social services characteristics, life styles, physical illnesses and chronic diseases, mental, emotional and cognition disorders, quality of life, disabilities, sleep quality, social supports, life satisfaction, self-efficacy, and of participants...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28919725/correlations-between-satisfaction-with-life-and-selected-personal-resources-among-students-of-universities-of-the-third-age
#6
Halina Zielińska-Więczkowska
PURPOSE: The aim of the study was to identify personal resources, including health-related resources, sense of self-efficacy, attitude to life (optimism/pessimism) and self-assessment, and to determine their relationship with satisfaction with life in members of the Universities of the Third Age (U3As) in Poland. The impact of sociodemographic factors was analyzed. MATERIALS AND METHODS: The study included 320 participants of U3As; their mean age was 67.5 years and the vast majority of them were women (92...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28919314/24-hour-alberta-stroke-program-early-ct-score-assessment-in-post-stroke-spasticity-development-in-patients-with-a-first-documented-anterior-circulation-ischemic-stroke
#7
Ondrej Volny, Maria Justanova, Petra Cimflova, Linda Kasickova, Ivana Svobodova, Jan Muzik, Martin Bares
BACKGROUND: Neuroanatomic substrates responsible for development of post-stroke spasticity are still poorly understood. The study is focused on identification of brain regions within the territory of the middle cerebral artery associated with spasticity development. METHODS: This is a single-center prospective cohort study of first documented anterior circulation ischemic strokes with a neurologic deficit lasting >7 days (from March 2014 to September 2016, all patients are involved in a registry)...
September 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28919195/combination-versus-monotherapy-for-gram-negative-bloodstream-infections-matching-by-predicted-prognosis
#8
Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Helmut Albrecht, Majdi N Al-Hasan
The utility of empirical combination antimicrobial therapy for gram-negative bloodstream infections (BSI) remains unclear. This retrospective, quasi-experimental matched cohort study examined the impact of empirical combination therapy on mortality in patients with gram-negative BSI. Hospitalized adults with gram-negative BSI from 1 January 2010 to 31 December 2013 at Palmetto Health Hospitals in Columbia, SC, USA were identified. Patients receiving combination or beta-lactam monotherapy therapy were matched 1:1 based on age, sex and Bloodstream Infection Mortality Risk Score (BSIMRS)...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28918861/exercise-self-efficacy-correlates-in-people-with-psychosis
#9
Davy Vancampfort, Paul Gorczynski, Marc De Hert, Michel Probst, Annetie Naisiga, David Basangwa, James Mugisha
Despite the recognition of the importance of exercise self-efficacy in exercise adoption and maintenance, previous investigations on exercise self-efficacy in people with psychosis is scarce. The present study aimed to (1) explore if exercise self-efficacy differed between stages of behavior change in Ugandan outpatients with psychosis, and (2) assess sociodemographic, clinical and motivational correlates of exercise self-efficacy. In total, 48 patients (24 women) completed the Exercise Self-Efficacy Scale (ESES), the Patient-centered Assessment and Counseling for Exercise questionnaire, the Brief Symptoms Inventory-18 (BSI-18), and questions pertaining to intrinsic motivation in the Behavioral Regulation in Exercise Questionnaire-2...
September 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918533/the-associations-between-dietary-patterns-and-bone-health-according-to-the-tgf-%C3%AE-1-t869%C3%A2-c-polymorphism-in-postmenopausal-iranian-women
#10
Sajjad Moradi, Leila Khorrami-Nezhad, Sima Ali-Akbar, Fatemeh Zare, Tanaz Alipour, Azadeh Dehghani Kari Bozorg, Mir Saeed Yekaninejad, Zhila Maghbooli, Khadijeh Mirzaei
BACKGROUND/OBJECTIVE: Recent studies have shown that dietary variants and genetic variants play a decisive role in the risk of developing osteoporosis. Therefore, the objective of the present study was to examine associations between dietary pattern and bone health, according to the TGF-β1 T869→C polymorphism, in postmenopausal Iranian women. MATERIALS AND METHODS: In this study, 264 postmenopausal women aged from 46 to 78 years were examined. Body composition was measured by a body composition analyzer and physical activity by the short-form physical activity questionnaire...
September 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28918171/the-association-between-delirium-and-sarcopenia-in-older-adult-patients-admitted-to-acute-geriatrics-units-results-from-the-glisten-multicenter-observational-study
#11
Giuseppe Bellelli, Antonella Zambon, Stefano Volpato, Pasquale Abete, Lara Bianchi, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Giovanna Maria Manca, Maria Rosaria Rizzo, Andrea Rossi, Francesco Landi
BACKGROUND & AIMS: To date, studies assessing the relationship between sarcopenia and delirium, two of the most common geriatric syndromes, are lacking. We sought to explore this association by investigating the co-occurrence of these two conditions and the independent association between them in a population of hospitalized older adults. METHODS: Cross-sectional multicenter analysis of older adults consecutively admitted to 12 acute geriatric units (AGUs). Sarcopenia was assessed upon admission by evaluating the presence of low skeletal mass index (kg/m(2)), and either low handgrip strength or low walking speed (European Working Group on Sarcopenia in Older People, EWGSOP criteria)...
September 5, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28917651/bacteriophages-as-an-alternative-to-conventional-antibiotic-use-for-the-prevention-or-treatment-of-paenibacillus-larvae-in-honeybee-hives
#12
T Scott Brady, Bryan D Merrill, Jared A Hilton, Ashley M Payne, Michael B Stephenson, Sandra Hope
American Foulbrood (AFB) is an infectious disease caused by the bacteria, Paenibacillus larvae. P. larvae phages were isolated and tested to determine each phages' host range amongst 59 field isolate strains of P. larvae. Three phages were selected to create a phage cocktail for the treatment of AFB infections according to the combined phages' ability to lyse all tested strains of bacteria. Studies were performed to demonstrate the safety and efficacy of the phage cocktail treatment as a replacement for traditional antibiotics for the prevention of AFB and the treatment of active infections...
September 13, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28917205/prenatal-ddt-exposure-and-child-adiposity-at-age-12-the-chamacos-study
#13
Marcella Warner, Morgan Ye, Kim Harley, Katherine Kogut, Asa Bradman, Brenda Eskenazi
OBJECTIVE: Using data from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) birth cohort study, we assessed the association of in utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenylethylene (DDE) with child adiposity at age 12. METHODS: We included 240 children with o,p'-DDT, p,p'-DDT, and p,p'-DDE concentrations measured in maternal serum collected during pregnancy (ng/g lipid) and complete 12-year follow-up data...
September 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/28916962/effects-of-cholecystectomy-on-recurrent-biliary-complications-after-endoscopic-treatment-of-common-bile-duct-stone-a-population-based-cohort-study
#14
Chi-Tung Cheng, Chun-Nan Yeh, Kun-Chun Chiang, Ta-Sen Yeh, Kuan-Fu Chen, Shao-Wei Chen
BACKGROUND: The aim of this study was to evaluate the benefits of cholecystectomy on mitigating recurrent biliary complications following endoscopic treatment of common bile duct stone. METHODS: We used the data from the Taiwan National Health Insurance Research Database to conduct a population-based cohort study. Among 925 patients who received endoscopic treatment for choledocholithiasis at the first admission from 2005 to 2012, 422 received subsequent cholecystectomy and 503 had gallbladder (GB) left in situ...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916936/does-diabetes-mellitus-comorbidity-affect-in-hospital-mortality-and-length-of-stay-analysis-of-administrative-data-in-an-italian-academic-hospital
#15
Francesca Valent, Laura Tonutti, Franco Grimaldi
AIMS: Hospitalized patients with comorbid diabetes mellitus may have worse outcomes than the others. We conducted a study to assess whether comorbid diabetes affects in-hospital mortality and length of stay. METHODS: For this population-based study, we analyzed the administrative databases of the Regional Health Information System of the Region Friuli Venezia Giulia, where the Hospital of Udine is located. Hospital discharge data were linked at the individual patient level with the regional Diabetes Mellitus Registry to identify diabetic patients...
September 15, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28916916/investigating-baseline-red-meat-slaughter-operator-capacity-and-directions-for-development-in-lao-pdr
#16
Joanne C Thomas, James R Young, Kathrin Schemann, Phaivanh Chankhamthong, Syseng Khounsy, Sonevilay Nampanya, Peter A Windsor, Russell D Bush
A study of operator knowledge, attitudes and practices (KAP) in red meat slaughter premise operations in northern Laos was conducted and compared with international best practice, to inform future industry development. The survey interviewed 68 (of 94 possible participants) employees from all ten commercial slaughter premises in six districts in three northern Laos provinces. This was supported by observations of slaughter premises, processes and the conduct of personnel. Descriptive analysis and linear regression modelling identified significant KAP predictor factors, and a gap analysis supported or rejected inferences from the generally low KAP scores for human and animal health, animal welfare, good manufacturing practices (GMP), work conditions and economics...
September 15, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28916238/association-of-midlife-lipids-with-20-year-cognitive-change-a-cohort-study
#17
Melinda C Power, Andreea Rawlings, A Richey Sharrett, Karen Bandeen-Roche, Josef Coresh, Christie M Ballantyne, Yashashwi Pokharel, Erin D Michos, Alan Penman, Alvaro Alonso, David Knopman, Thomas H Mosley, Rebecca F Gottesman
INTRODUCTION: Existing studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health. METHODS: We quantified the association between measured serum lipids in midlife and subsequent 20-year change in performance on three cognitive tests in 13,997 participants of the Atherosclerosis Risk in Communities study. RESULTS: Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides were associated with greater 20-year decline on a test of executive function, sustained attention, and processing speed...
September 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28915804/prevalence-and-predictors-of-persistent-pelvic-girdle-pain-12%C3%A2-years-postpartum
#18
Cecilia Bergström, Margareta Persson, Kari-Anne Nergård, Ingrid Mogren
BACKGROUND: Pelvic girdle pain (PGP) is not always a self-limiting condition. Women with more pronounced persistent PGP (PPGP) report poorer health status compared to women with less pronounced symptoms. The knowledge concerning the long-term consequences of PPGP is limited, thus more knowledge in this area is needed. The overall aim was to study the prevalence and predictors of PPGP 12 years after delivery. METHODS: This is a long-term follow-up study based on a previous cohort study that commenced in 2002...
September 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28915772/hypermobility-in-adolescent-athletes-pain-functional-ability-quality-of-life-and-musculoskeletal-injuries
#19
Heidi Schmidt, Trine Lykke Pedersen, Tina Junge, Raoul Engelbert, Birgit Juul-Kristensen
Study Design Cross-sectional. Background Generalised joint hypermobility (GJH) may increase pain and likelihood of injuries and also decrease function and health-related quality of life (HRQoL) in elite level adolescent athletes. Objectives To assess the prevalence of GJH in elite level adolescent athletes, and to study the association of GJH with pain, function, HRQoL, and musculoskeletal injuries. Methods A total of 132 elite level adolescent athletes (36 males; 96 females), mean (SD) age 14.0 (0.9) years, participated (n=22 ballet dancers, n=57 teamgym gymnasts, n=53 team handball players)...
September 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28915694/association-of-pre-operative-depressive-and-anxiety-symptoms-with-five-year-survival-of-glioma-and-meningioma-patients-a-prospective-cohort-study
#20
Adomas Bunevicius, Vytenis Pranas Deltuva, Arimantas Tamasauskas
BACKGROUND: Mental symptoms are common and associated with worse health status of brain tumor patients. We evaluated the association of pre-operative depressive and anxiety symptoms with 5-year mortality of glioma and meningioma patients. METHODS: One-hundred and fifty-two patients (mean age 56.9±14.7 years, 69% women) were evaluated for functional status (Barthel index), and depressive and anxiety symptom severity (Hospital Anxiety and Depression scale or HADS)...
August 22, 2017: Oncotarget
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