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https://www.readbyqxmd.com/read/28823133/genetic-association-of-swine-leukocyte-antigen-class-ii-haplotypes-and-body-weight-in-microminipigs
#1
Tatsuya Matsubara, Masaki Takasu, Noriaki Imaeda, Naohito Nishii, Satoshi Takashima, Takashi Nishimura, Toshiaki Nishimura, Takashi Shiina, Asako Ando, Hitoshi Kitagawa
Objective: Microminipigs are a novel animal model with extensive applications in laboratory studies owing, in part, to their extremely small body sizes. In this study, the relationship between swine leukocyte antigen (SLA) class II haplotype and body weight was evaluated in the Microminipig population. Methods: A total of 1,900 haplotypes, covering SLA class II haplotypes Lr-0.7, Lr-0.23, Lr-0.17, Lr-0.37, Lr-0.16, Lr-0.11, Lr-0.13, and Lr-0.18, were analyzed in 950 piglets...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28823099/evidence-of-dysexecutive-syndrome-in-patients-with-acromegaly
#2
Shaobo Shan, Lingling Fang, Jia Huang, Raymond C K Chan, Guijun Jia, Weiqing Wan
PURPOSE: This study aimed to explore different aspects of executive function in patients with acromegaly and investigate the cause of dysexecutive syndrome in these patients. METHODS: We conducted five typical executive function tests (Stroop test, verbal fluency [VF] test, Hayling Sentence Completion Test [HSCT], N-back test, and Sustained Attention to Response Task [SART]) on 42 acromegalic patients and 42 strictly matched healthy controls. Comparative analyses were conducted for five major executive function domains...
August 19, 2017: Pituitary
https://www.readbyqxmd.com/read/28823075/refractive-corneal-and-ocular-residual-astigmatism-distribution-in-a-german-population-and-age-dependency-the-gutenberg-health-study
#3
Alexander Karl-Georg Schuster, Norbert Pfeiffer, Andreas Schulz, René Hoehn, Katharina A Ponto, Philipp S Wild, Maria Blettner, Manfred E Beutel, Karl J Lackner, Thomas Münzel, Alireza Mirshahi
PURPOSE: Worldwide, the most frequent cause of visual impairment is uncorrected refractive error. This analysis focused on the distribution and associations of refractive, corneal and ocular residual astigmatism. METHODS: As part of the Gutenberg Health study, a population-based cross-sectional study was conducted in the general population of Germany. A comprehensive ophthalmological examination including refraction, tonometry, and Scheimpflug imaging of the anterior cornea (Pachycam) was performed...
August 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28823045/killing-activity-of-lfchimera-on-periodontopathic-bacteria-and-multispecies-oral-biofilm-formation-in-vitro
#4
Sopita Ruangcharoen, Waraporn Suwannarong, Marie Rossini Carmela T Lachica, Jan G M Bolscher, Kamran Nazmi, Watcharee Khunkitti, Suwimol Taweechaisupapong
Lactoferrin chimera (LFchimera), a heterodimeric peptide containing lactoferrampin (LFampin265-284) and a part of lactoferricin (LFcin17-30), possesses a broad spectrum of antimicrobial activity. However, there is no report on the inhibitory effects of LFchimera against multispecies oral biofilms. This study aimed to determine the effects of LFchimera in comparison to chlorhexidine digluconate (CHX) and minocycline hydrochloride (MH), on in vitro multispecies biofilms derived from subgingival plaque of periodontitis patients harboring Aggregatibacter actinomycetemcomitans...
August 19, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28823015/effects-of-eutrophication-on-diatom-abundance-biovolume-and-diversity-in-tropical-coastal-waters
#5
Joon Hai Lim, Choon Weng Lee
Diatom abundance, biovolume and diversity were measured over a 2-year period along the Straits of Malacca at two stations with upper (Klang) and lower (Port Dickson) states of eutrophication. Diatom abundance, which ranged from 0.2 × 10(4) to 21.7 × 10(4) cells L(-1) at Klang and 0.9 × 10(3)- 41.3 × 10(3) cells L(-1) at Port Dickson, was influenced partly by nutrient concentrations. At Klang, the diatoms were generally smaller and less diverse (H' = 0.77 ± 0.48) and predominated by Skeletonema spp...
August 3, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28822986/insights-in-pathogenesis-of-multiple-sclerosis-nitric-oxide-may-induce-mitochondrial-dysfunction-of-oligodendrocytes
#6
Minghong Lan, Xiaoyi Tang, Jie Zhang, Zhongxiang Yao
Demyelinating diseases, such as multiple sclerosis (MS), are kinds of common diseases in the central nervous system (CNS), and originated from myelin loss and axonal damage. Oligodendrocyte dysfunction is the direct reason of demyelinating lesions in the CNS. Nitric oxide (NO) plays an important role in the pathological process of demyelinating diseases. Although the neurotoxicity of NO is more likely mediated by peroxynitrite rather than NO itself, NO can impair oligodendrocyte energy metabolism through mediating the damaging of mitochondrial DNA, mitochondrial membrane and mitochondrial respiratory chain complexes...
August 21, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28822973/pai-1-levels-are-related-to-insulin-resistance-and-carotid-atherosclerosis-in-subjects-with-familial-combined-hyperlipidemia
#7
Arturo Carratala, Sergio Martinez-Hervas, Enrique Rodriguez-Borja, Esther Benito, José T Real, Guillermo T Saez, Rafael Carmena, Juan F Ascaso
Familial combined hyperlipidemia (FCH) is a primary atherogenic dyslipidemia with insulin resistance and increased cardiovascular risk. Plasminogen activator inhibitor type 1 (PAI-1) and myeloperoxidase (MPO) activity are associated with proinflammatory and atherothrombotic risk. Our aim was to study the role played by PAI-1 and MPO activity in the carotid atherosclerosis prevalence in FCH subjects. 36 FCH unrelated subjects (17 women) were matched by age and body weight with 36 healthy normolipidemic subjects (19 female)...
August 19, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28822962/glucose-transporter-4-glut4-deficient-hearts-develop-maladaptive-hypertrophy-in-response-to-physiologic-or-pathologic-stresses
#8
Adam Raymond Wende, Jaetaek Kim, William Holland, Benjamin E Wayment, Brian T O'Neill, Joseph Tuinei, Manoja K Brahma, Mark E Pepin, Mark A McCrory, Ivan Luptak, Ganesh V Halade, Sheldon E Litwin, E Dale Abel
Pathological cardiac hypertrophy may be associated with reduced expression of the GLUT4 glucose transporter in contrast to exercise-induced cardiac hypertrophy, where GLUT4 levels are increased. However, mice with cardiac specific deletion of GLUT4 (G4H-/-) have normal cardiac function in the unstressed state. This study tested the hypothesis that cardiac GLUT4 is required for myocardial adaptations to hemodynamic demands. G4H-/- and control littermates (Con) were subjected to either a pathological model of left ventricular pressure overload (transverse aortic constriction; TAC) or a physiological model of endurance exercise (swim training)...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822960/loss-of-perilipin-2-in-cultured-myotubes-enhances-lipolysis-and-redirects-the-metabolic-energy-balance-from-glucose-oxidation-towards-fatty-acid-oxidation
#9
Yuan Z Feng, Jenny Lund, Yuchuan Li, Irlin K Knabenes, Siril S Bakke, Eili Tranheim Kase, Yun K Lee, Alan R Kimmel, G Hege Thoresen, Arild Christian Rustan, Knut Tomas Dalen
Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2-/- mice contain reduced content of LDs and accumulate less oleic acid in triacylglycerol (TAG), due to elevated LD hydrolysis compared to Plin2+/+ myotubes. The reduced ability to store TAG in LDs in Plin2-/- myotubes is accompanied by a shift in energy metabolism...
August 19, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28822936/influence-of-coupled-ocean-atmosphere-phenomena-on-the-greater-horn-of-africa-droughts-and-their-implications
#10
Freddie Mpelasoka, Joseph L Awange, Ayalsew Zerihun
Drought-like humanitarian crises in the Greater Horn of Africa (GHA) are increasing despite recent progress in drought monitoring and prediction efforts. Notwithstanding these efforts, there remain challenges stemming from uncertainty in drought prediction, and the inflexibility and limited buffering capacity of the recurrent impacted systems. The complexity of the interactions of ENSO, IOD, IPO and NAO, arguably remains the main source of uncertainty in drought prediction. To develop practical drought risk parameters that potentially can guide investment strategies and risk-informed planning, this study quantifies, drought characteristics that underpin drought impacts management...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822877/assessment-of-tobacco-heating-product-thp1-0-part-8-study-to-determine-puffing-topography-mouth-level-exposure-and-consumption-among-japanese-users
#11
Jodie Gee, Krishna Prasad, Sandra Slayford, Adam Gray, Kathryn Nother, Anthony Cunningham, Eleni Mavropoulou, Christopher Proctor
A four-arm study was undertaken in Japan to determine the puffing topography, mouth level exposure and average daily consumption by consumers of the tobacco heating products (THPs): the non-mentholated THP1.0(T), the mentholated THP1.0(M) and a tobacco heating system (THS). The extent of lip blocking of air inlet holes while using THP1.0(T) was also assessed. Groups 1, 2, and 4 included smokers, and group 3 included regular THP users. Smokers of 7-8 mg ISO nicotine free dry particulate matter (NFDPM) non-mentholated cigarettes took on average larger mean puff volumes from THPs than from conventional cigarettes, but puff numbers and durations were similar...
August 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28822865/formation-and-morphogenesis-of-a-cuttlebone-s-aragonite-biomineral-structures-for-the-common-cuttlefish-sepia-officinalis-on-the-nanoscale-revisited
#12
Vida Čadež, Srečo D Škapin, Adrijana Leonardi, Igor Križaj, Saša Kazazić, Branka Salopek-Sondi, Ivan Sondi
This study describes and examines the structural and morphological properties of the hierarchically organized, aragonite cuttlebone forms for the common cuttlefish (Sepia officinalis, L.), including its main structural parts, the dorsal shield, and the chambers. Specifically, it complements the mechanism for the self-organized formation of aragonite, identifies the presence, and determines the role of soluble organic matrix (SOM) proteins in the morphogenesis of the cuttlebone's biomineral structures on the nanoscale...
August 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822781/inpatient-versus-outpatient-parenteral-antibiotic-therapy-at-home-for-acute-infections-in-children-a-systematic-review
#13
REVIEW
Penelope A Bryant, Naomi T Katz
Inpatient management is necessary in many situations, but medical and allied-health treatments are increasingly being used on an outpatient basis to allow patients who would traditionally have been admitted to hospital to remain at home. Home-based clinical management has many potential benefits, including reduced hospital-acquired infections, cost savings, and patient and family satisfaction. Studies in adults provide evidence for the benefits of home-based versus hospital-based intravenous antibiotics, but few studies inform practice in home-based intravenous antibiotic therapy for children...
August 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28822712/socioeconomic-inequality-in-childhood-obesity-and-its-determinants-in-iran-a-blinder-oaxaca-decomposition
#14
Roya Kelishadi, Mostafa Qorbani, Ramin Heshmat, Shirin Djalalinia, Ali Sheidaei, Saeid Safiri, Nastaran Hajizadeh, Mohammad Esmaeil Motlagh, Gelayol Ardalan, Hamid Asayesh, Morteza Mansourian
OBJECTIVE: Childhood obesity has become a priority health concern worldwide. Socioeconomic status (SES) is one of its main determinants. This study aimed to assess the socioeconomic inequality of obesity in children and adolescents at national and provincial levels in Iran. METHODS: This multicenter cross-sectional study was conducted in 2011-2012, as part of a national school-based surveillance program performed in 40,000 students, aged 6-18-years, from urban and rural areas of 30 provinces of Iran...
August 17, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28822648/cyclooxygenase-2-inhibitors-and-free-flap-complications-after-autologous-breast-reconstruction-a-retrospective-cohort-study
#15
Christian Bonde, Hoda Khorasani, Jens Hoejvig, Henrik Kehlet
BACKGROUND: A key component of modern analgesics is the use of multimodal opioid-sparing analgesia (MOSA). In the past, our analgesic regime after autologous breast reconstruction (ABR) included either NSAID or a selective cyclooxygenase-2 (COX-2) inhibitor. COX-2 inhibitors are superior to NSAIDs because of the well-known side effects of NSAID treatment (bleeding/gastrointestinal ulcers). However, COX-2 inhibitors have been suggested to increase flap failure rates. We report our experience in using COX-2 inhibitors as part of our post-operative MOSA after ABR using free flaps...
June 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28822623/high-resolution-computed-tomography-features-distinguishing-benign-and-malignant-lesions-manifesting-as-persistent-solitary-subsolid-nodules
#16
Wenjia Yang, Yifeng Sun, Wentao Fang, Fangfei Qian, Jianding Ye, Qunhui Chen, Yifeng Jiang, Keke Yu, Baohui Han
INTRODUCTION: We retrospectively investigated the high-resolution computed tomography features that distinguish benign lesions (BLs) from malignant lesions (MLs) appearing as persistent solitary subsolid nodules (SSNs). MATERIALS AND METHODS: In 2015, the data from patients treated in our department with persistent solitary SSNs 5 to 30 mm in size were analyzed retrospectively. The demographic data and HRCT findings were analyzed and compared between those with BLs and MLs...
June 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28822615/alcohol-use-and-problem-drinking-among-women-firefighters
#17
Christopher K Haddock, Walker S C Poston, Sara A Jahnke, Nattinee Jitnarin
OBJECTIVES: Given high levels of occupational stress and toxic exposures, firefighters have a relatively high prevalence of occupationally related medical and mental health disorders compared with the general public. Previous research found high rates of heavy and binge drinking among male firefighters. This study is the first to examine alcohol use among women firefighters. METHODS: Data were collected as part of a national online survey of women, career firefighters...
August 16, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28822588/characterization-of-reactive-flow-induced-evolution-of-carbonate-rocks-using-digital-core-analysis-part-2-calculation-of-the-evolution-of-percolation-and-transport-properties
#18
Jafar Qajar, Christoph H Arns
Percolation of reactive fluids in carbonate rocks affects the rock microstructure and hence changes the rock macroscopic properties. In Part 1 paper, we examined the voxel-wise evolution of microstructure of the rock in terms of mineral dissolution/detachment, mineral deposition, and unchanged regions. In the present work, we investigate the relationships between changes in two characteristic transport properties, i.e. permeability and electrical conductivity and two critical parameters of the pore phase, i...
August 12, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28822586/intravenous-mannitol-versus-placebo-during-partial-nephrectomy-in-patients-with-normal-kidney-function-a-double-blind-clinically-integrated-randomized-trial
#19
Massimiliano Spaliviero, Nicholas E Power, Katie S Murray, Daniel D Sjoberg, Nicole E Benfante, Melanie L Bernstein, James Wren, Paul Russo, Jonathan A Coleman
BACKGROUND: Mannitol is currently used as a renal protective agent to mitigate the effects of renal ischemia during nephron-sparing surgery (NSS). This routine practice lacks rigorous methodological study. OBJECTIVE: To assess the effect on renal function outcomes after surgery of mannitol infusion prior to renal ischemia during NSS. DESIGN, SETTING, PARTICIPANTS: This prospective, randomized, placebo-controlled, double-blind trial included 199 patients with a preoperative estimated glomerular filtration rate (eGFR) >45ml/min/1...
August 16, 2017: European Urology
https://www.readbyqxmd.com/read/28822583/-misuse-and-adverse-effects-of-new-direct-oral-anticoagulants-a-prospective-observational-study-in-patients-admitted-to-an-emergency-unit-of-a-french-university-hospital
#20
Thomas Lafon, Christine Vallejo, Mathilde Hadj, Marie-Laure Laroche, Hélène Geniaux
INTRODUCTION: The use of direct oral anticoagulants (NOAC) is complex: indications, dosage adjustments and precautions. Emergency departments (ED) are increasingly faced with patients receiving NOAC. The aim of this study was to evaluate the misuse and the adverse effects (AE) of NOAC. METHODS: All subjects with NOAC admitted to the Limoges University Hospital ED from 1/8/2013 to 1/4/2014 were included in a prospective observational study. Misuse was identified from the NOAC summary of product characteristics and from the 2014 ANSM guideline (indication, dose, co-medications, age, hepatic and renal function); adverse effects were recorded...
July 19, 2017: Thérapie
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