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https://www.readbyqxmd.com/read/29458225/-indication-quality-concepts-and-ethical-implications
#1
Andrea Dörries
BACKGROUND: In recent times - also due to new laws - a good "indication quality" has been called for. The aim of this paper is to contribute to the debate about "indication quality" by looking into the meaning of the term "indication" as well as the meaning of an adequate understanding of quality. METHODS: Initially, a conceptual analysis is made of how indication is an integral part of the therapeutic decision-making process between physician and patient, in which, next to evidence-based elements, also normative elements are included (step 1)...
February 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29458183/age-dependent-attitudes-of-ischemic-patients-towards-disability-after-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-infarction
#2
Byoung-Joon Kim, Yeon Ran Hong, Youngmin Han, Yang-Ha Hwang, Boram Ohk, Jaechan Park
OBJECTIVE: To improve the process of surgical informed consent, patient attitudes towards acceptable levels of disability after decompressive surgery for malignant middle cerebral artery infarction are investigated, including the impact of patient age. METHODS: Patients who had experienced a recent minor stroke were asked to complete a questionnaire comprised of 2 parts: 1) demographic information, including patient age, gender, years of education, working status, religion, and economic status and 2) acceptable level of disability based on a modified Rankin Scale (mRS) with corresponding illustrations to explain the mRS levels...
February 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29458147/sessein-and-isosessein-with-anti-inflammatory-antibacterial-and-antioxidant-activity-isolated-from-salvia-sessei-benth
#3
Abraham Gómez-Rivera, Manasés González-Cortazar, Maribel Herrera-Ruíz, Alejandro Zamilpa, Verónica Rodríguez-López
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia sessei Benth, popularly known as "pipilolxochitl" or "sabanito", is a plant utilized in Mexico in traditional medicine for the treatment of erysipela. To date, only one report, to our knowledge, has been found in which a royleanone-type diterpene of the aerial parts of the species was isolated but, again to our knowledge, studies have not been conducted on the pharmacological activity of extracts and compounds isolated from this plant...
February 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29458070/the-epigenetic-alterations-of-endogenous-retroelements-in-aging
#4
REVIEW
Maurizio Cardelli
Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic parasites, but also exert regulatory roles in living cells. The risk of genomic instability represented by endogenous retroelements is normally counteracted by a series of epigenetic control mechanisms which include, among the most important, CpG DNA methylation...
February 16, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29458026/knockdown-of-fascin-1-expression-suppresses-cell-migration-and-invasion-of-non-small-cell-lung-cancer-by-regulating-the-mapk-pathway
#5
Da Zhao, Tao Zhang, Xiao-Ming Hou, Xiao-Ling Ling
Fascin-1 is a cytoskeletal protein and it can specifically bind to F-actin, it can be abnormally expressed in a variety of solid tumors. Fascin-1 was identified as a factor for poor prognosis in non-small cell lung cancer (NSCLC). However, the relevant molecular mechanisms are not yet fully understood. In this study, the fascin-1 knockdown cells were produced by lentivirus infection, and then cell proliferation, invasion and cell migration assay were used to investigate the role of fascin-1 in NSCLC cells. The MAPK pathway related proteins were determined by western blot...
February 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29457875/variations-of-the-circle-of-willis-at-the-end-of-the-human-embryonic-period
#6
Kana Furuichi, Aoi Ishikawa, Chigako Uwabe, Haruyuki Makishima, Shigehito Yamada, Tetsuya Takakuwa
Variations of the circle of Willis (CW) influence blood supply to the brain and adjacent structures in adults. We examined the formation of the CW in 20 human embryo samples at the end of the embryonic period using 3-D reconstructions of serial histological sections. The CW was closed in all samples, and did not form in a single plane, but was composed of multiple stair-like planes. The artery acutely curved at the caudal part of the CW, namely at the inlet of the basilar artery and bifurcation of the P1 segment of the posterior cerebral artery (PCA), reflecting flexure of the mesencephalon and diencephalon at this stage...
February 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29457786/intracellular-lipid-metabolism-impairs-%C3%AE-cell-compensation-during-diet-induced-obesity
#7
Risheng Ye, Ruth Gordillo, Mengle Shao, Toshiharu Onodera, Zhe Chen, Shiuhwei Chen, Xiaoli Lin, Jeffrey A SoRelle, Xiaohong Li, Miao Tang, Mark P Keller, Regina Kuliawat, Alan D Attie, Rana K Gupta, William L Holland, Bruce Beutler, Joachim Herz, Philipp E Scherer
The compensatory proliferation of insulin-producing β cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of β cells to proliferate results in hyperglycemia and insulin dependence in patients. To understand the effect of the interplay between β cell compensation and lipid metabolism upon obesity and peripheral insulin resistance, we eliminated LDL receptor-related protein 1 (LRP1), a pleiotropic mediator of cholesterol, insulin, energy metabolism, and other cellular processes, in β cells...
February 19, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29457392/-analysis-on-the-occult-blood-loss-after-unicompartment-knee-arthroplasty
#8
Zhan-Feng Zhang, Ji-Kang Min, Dan Wang, Jian-Ming Zhong, Heng Li
OBJECTIVE: To calculate the volume of occult blood loss after unicompartment knee arthroplasty(UKA), and analyze its influential factors by comparing with total knee arthroplasty. METHODS: A retrospective study of 130 cases from July 2012 to July 2015 were enrolled, of which and 65 cases were UKA, and 65 cases were TKA. In UKA group there were 27 males and 38 females, and the mean age was (62.3±4.3) years old (ranged, 50 to 82 years old). There were 14 cases older than 70 years old, while 51 cases among 50 to 70 years old...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457371/validation-of-a-blood-marker-for-plasma-volume-in-endurance-athletes-during-a-live-high-train-low-altitude-training-camp
#9
Louisa M Lobigs, Laura A Garvican-Lewis, Victor L Vuong, Nicolin Tee, Christopher J Gore, Peter Peeling, Brian Dawson, Yorck O Schumacher
Altitude is a confounding factor within the Athlete's Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; hemoglobin concentration ([Hb]) and the OFF-score. Endurance athletes (n=34) completed a 21 night simulated live high: train low protocol (14h.d-1 at 3000m). Bloods were collected twice pre-altitude, at days 3, 8 and 15 at altitude and 1, 7, 21 and 42 days post-altitude...
February 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29456939/outcomes-of-bone-anchored-hearing-aid-implant-at-universiti-kebangsaan-malaysia-medical-centre-ukmmc
#10
Suhana Abdul Rahim, Bee-See Goh, Safinaz Zainor, Roslenda Abdul Rahman, Asma Abdullah
The cross sectional study was conducted in Universiti Kebangsaan Malaysia Medical Center (UKMMC), Malaysia from August 2012 to December 2013. All patients implanted with in UKMMC from December 2001 until December 2012 was included. Glasgow Benefit Inventory (GBI) questionnaires and UKMMC questionnaires were used as part of the assessment tool. The GBI is a scoring which measures the change in health status produced by surgical interventions. UKMMC questionnaires was invented by our department to assess questions related to social and life style of patients and also the cosmetic perspective Baha implant and other daily related activities...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456938/deep-neck-space-infections-a-study-in-diabetic-population-in-a-tertiary-care-centre
#11
Kalpana Sharma, Devjani Das, Manish Joshi, Dipjyoti Barman, A J Sarma
This study is intended to analyze the clinical profile and outcomes of deep neck space infection in diabetic patients in our tertiary care centre. A prospective study of 1 year duration from 30th September 2015 to 30th September 2016 at department of Otorhinolaryngology, Gauhati Medical College and Hospital, Guwahati. A total of 45 diabetic patients who presented with DNSI are included in this study. Their demographic profile, etiology, bacteriology, treatment, duration of hospital stay, complications and outcomes have been analyzed...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456811/-in-vivo-activity-assessment-of-some-tanacetum-species-used-as-traditional-wound-healer-along-with-identification-of-the-phytochemical-profile-by-a-new-validated-hplc-method
#12
Serkan Özbilgin, Esra Küpeli Akkol, Burçin Ergene Öz, Mert Ilhan, Gülçin Saltan, Özlem Bahadır Acıkara, Mehmet Tekin, Hikmet Keleş, Ipek Süntar
Objectives: Tanacetum species are traditionally used as insecticide, and externally wound healer as well as for anti-inflammatory and antihistaminic properties. The in vivo wound-healing and anti-inflammatory potential of four Tanacetum species, Tanacetum argenteum (Lam.) Willd. subsp. argenteum (TA) , Tanacetum heterotomum (Bornm.) Grierson (TH), Tanacetum densum (Lab.) Schultz Bip. subsp. sivasicum (TD), and Tanacetum vulgare L. (TV) was investigated. Materials and Methods: The chloroform (CHCl3 ) and methanol:water (80:20) extracts were prepared from the aerial parts of each plant...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456589/employment-status-and-changes-in-working-career-in-relation-to-asthma-a-cross-sectional-survey
#13
Saara Taponen, Lauri Lehtimäki, Kirsi Karvala, Ritva Luukkonen, Jukka Uitti
Background: Asthmatics confront inconveniences in working life that make it more difficult to pursue a sustainable career, such as unemployment and work disability. Ways of dealing with these inconveniences may be career changes. More needs to be known about the backgrounds and consequences of career changes among asthmatics, especially their relation to asthma or a change in asthma symptoms. The aim of this study was to compare earlier career changes of adults with asthma who are working full time to those who have drifted away from active working life because of work disability, unemployment or early retirement...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29456445/concurrent-validation-of-a-pressure-pain-threshold-scale-for-individuals-with-myofascial-pain-syndrome-and-fibromyalgia
#14
Scott W Cheatham, Morey J Kolber, G Monique Mokha, William J Hanney
Background: Manual pressure palpation is an examination technique used in the classification of myofascial pain syndrome (MPS) and fibromyalgia (FM). Currently, there are no validated systems for classifying results. A valid and reliable pressure pain threshold scale (PPTS) may provide a means for clinicians to grade, document, and report findings. The purpose of this investigation was to validate a PPTS in individuals diagnosed with MPS and FM. Intra-rater reliability, concurrent validity, minimum cut-off value, and patient responses were evaluated...
February 2018: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29456439/parent-training-and-skill-acquisition-and-utilization-among-spanish-and-english-speaking-latino-families
#15
Giovanni Ramos, Angela M Blizzard, Nicole E Barroso, Daniel M Bagner
In the U.S., there is a growing Latino population, in which parents primarily speak Spanish to their children. Despite the evidence that language preference is associated with level of acculturation and influences parenting practices in these families, no study has compared how Spanish-and English-speaking Latino families acquire and utilize the skills taught during parent-training programs such as Parent-Child Interaction Therapy (PCIT). Twenty-seven mother-infant Latino dyads received a home-based adaptation of the Child-Directed Interaction (CDI) phase of PCIT as part of a larger randomized control trial...
January 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29456307/awareness-knowledge-and-attitude-of-patients-toward-dental-implants-a-questionnaire-based-prospective-study
#16
Rajesh Hosadurga, Tenneti Shanti, Shashikanth Hegde, Rajesh Shankar Kashyap, Suryanarayan Maiya Arunkumar
Background: In developing nations like India awareness and education about dental implants as a treatment modality is still scanty. Aim: The study was conducted to determine the awareness, knowledge, and attitude of patients toward dental implants as a treatment modality among the general population and to assess the influence of personality characteristics on accepting dental implants as a treatment modality in general and as well as treatment group. Materials and Methods: A structured questionnaire-based survey was conducted on 500 randomly selected participants attending the outpatient department...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29456275/antimicrobial-packaging-based-on-%C3%A9-polylysine-bioactive-film-for-the-control-of-mycotoxigenic-fungi-in-vitro-and-in-bread
#17
C Luz, J Calpe, F Saladino, Fernando B Luciano, M Fernandez-Franzón, J Mañes, G Meca
ɛ-Poly-l-lysine (ɛ-PL) is a cationic peptide with a broad-spectrum antimicrobial activity. This study investigates the use of ɛ-PL as natural antimicrobial to inhibit fungal growth and to reduce aflatoxins (AFs) production. Antifungal activity of starch biofilms with different concentrations of ɛ-Poly-l-lysine (ɛ-PL) was determined in solid medium against Aspergillus parasiticus (AFs producer) and Penicillium expansum . Then, biofilms were tested as antimicrobial devices for the preservation of bread loaf inoculated with A...
January 2018: Journal of Food Processing and Preservation
https://www.readbyqxmd.com/read/29456264/hazardous-chemical-releases-occurring-in-school-settings-14-states-2008-2013
#18
Ayana R Anderson, Taniece R Eure, Maureen F Orr, Lloyd J Kolbe, Alan Woolf
Children are considered to be a vulnerabletion when it comes to exposures to hazardous substances. Schools, where children spend about one third of their day, are expected to be a safe environment. Yet, there are many hazardous substances in schools that can be inadvertently or intentionally released and harm the health of students and teachers alike. The purpose of this analysis is to characterize acute chemical release incidents in school settings and identify prevention practices. The acute chemical incident surveillance programs of the Agency for Toxic Substances and Disease Registry (ATSDR) captured 24,748 acute chemical release incidents from 14 states that participated during 2008-2013...
November 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29456257/irc-10-216-in-3-d-morphology-of-a-tp-agb-star-envelope
#19
M Guélin, N A Patel, M Bremer, J Cernicharo, A Castro-Carrizo, J Pety, J P Fonfría, M Agúndez, M Santander-García, G Quintana-Lacaci, L Velilla Prieto, R Blundell, P Thaddeus
During their late pulsating phase, AGB stars expel most of their mass in the form of massive dusty envelopes, an event that largely controls the composition of interstellar matter. The envelopes, however, are distant and opaque to visible and NIR radiation: their structure remains poorly known and the mass-loss process poorly understood. Millimeter-wave interferometry, which combines the advantages of longer wavelength, high angular resolution and very high spectral resolution is the optimal investigative tool for this purpose...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29456166/head-stabilisation-in-fast-running-lizards
#20
Jana Goyens, Peter Aerts
The cyclic patterns of terrestrial animal locomotion are frequently perturbed in natural environments. The terrain can be complex or inclined, the substrate can move unexpectedly and animals can misjudge situations. Loosing stability due to perturbations increases the probability of capture by predators and decreases the chance of successful prey capture and winning intraspecific battles. When controlled corrective actions are necessary to negotiate perturbations, animals rely on their exteroceptive and proprioceptive senses to monitor the environment and their own body movements...
November 29, 2017: Zoology: Analysis of Complex Systems, ZACS
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