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Pancreatic cancer imaging

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https://www.readbyqxmd.com/read/27903970/ion-channels-in-control-of-pancreatic-stellate-cell-migration
#1
Hannah Storck, Benedikt Hild, Sandra Schimmelpfennig, Sarah Sargin, Nikolaj Nielsen, Angela Zaccagnino, Thomas Budde, Ivana Novak, Holger Kalthoff, Albrecht Schwab
Pancreatic stellate cells (PSCs) play a critical role in the progression of pancreatic ductal adenocarcinoma (PDAC). Once activated, PSCs support proliferation and metastasis of carcinoma cells. PSCs even co-metastasise with carcinoma cells. This requires the ability of PSCs to migrate. In recent years, it has been established that almost all "hallmarks of cancer" such as proliferation or migration/invasion also rely on the expression and function of ion channels. So far, there is only very limited information about the function of ion channels in PSCs...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27897432/low-skeletal-muscle-radiation-attenuation-and-visceral-adiposity-are-associated-with-overall-survival-and-surgical-site-infections-in-patients-with-pancreatic-cancer
#2
David P J van Dijk, Maikel J A M Bakens, Mariëlle M E Coolsen, Sander S Rensen, Ronald M van Dam, Martijn J L Bours, Matty P Weijenberg, Cornelis H C Dejong, Steven W M Olde Damink
BACKGROUND: Cancer cachexia and skeletal muscle wasting are related to poor survival. In this study, quantitative body composition measurements using computed tomography (CT) were investigated in relation to survival, post-operative complications, and surgical site infections in surgical patients with cancer of the head of the pancreas. METHODS: A prospective cohort of 199 patients with cancer of the head of the pancreas was analysed by CT imaging at the L3 level to determine (i) muscle radiation attenuation (average Hounsfield units of total L3 skeletal muscle); (ii) visceral adipose tissue area; (iii) subcutaneous adipose tissue area; (iv) intermuscular adipose tissue area; and (v) skeletal muscle area...
October 26, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27893776/diagnostic-value-and-interreader-agreement-of-the-pancreaticolienal-gap-in-pancreatic-cancer-on-mdct
#3
Khoschy Schawkat, Wolfgang Kühn, Daniel Inderbitzin, Beat Gloor, Johannes T Heverhagen, Val Murray Runge, Andreas Christe
OBJECTIVE: The aim of this retrospective study was to evaluate the diagnostic value and measure interreader agreement of the pancreaticolienal gap (PLG) in the assessment of imaging features of pancreatic carcinoma (PC) on contrast-enhanced multi-detector computed tomography (CE-MDCT). MATERIALS AND METHODS: CE-MDCT studies in the portal venous phase were retrospectively reviewed for 66 patients with PC. The age- and gender-matched control group comprised 103 healthy individuals...
2016: PloS One
https://www.readbyqxmd.com/read/27890622/multi-functional-nanoparticles-as-theranostic-agents-for-treatment-imaging-in-pancreatic-cancer
#4
L R Jaidev, David Raj Chellappan, Dhiraj Vasanth Bhavsar, Ravi Ranganathan, Banudevi Sivanantham, Anuradha Subramanian, Uma Sharma, Narnamangalam R Jagannathan, Uma Maheswari Krishnan, Swaminathan Sethuraman
: Theranostics has received considerable attention since both therapy and imaging modalities can be integrated into a single nanocarrier. In this study, fluorescent iron oxide (FIO) nanoparticles and gemcitabine (G) encapsulated poly(lactide-co-glycolide) (PLGA) nanospheres (PGFIO) conjugated with human epidermal growth factor receptor 2, (HER-2) antibody (HER-PGFIO) were prepared and characterized. HER-PGFIO showed the magnetic moment of 10 emu/g, relaxivity (r2) of 773 mM(-1)s(-1) and specific absorption rate (SAR) of 183 W/g...
November 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27875519/expression-of-somatostatin-receptors-2-and-5-in-circulating-tumour-cells-from-patients-with-neuroendocrine-tumours
#5
Alexa Childs, Clare Vesely, Leah Ensell, Helen Lowe, Tu Vinh Luong, Martyn E Caplin, Christos Toumpanakis, Christina Thirlwell, John A Hartley, Tim Meyer
BACKGROUND: Neuroendocrine tumours (NET) overexpress somatostatin receptors (SSTR) that can be targeted for therapy. Somatostatin receptor expression is routinely measured by molecular imaging but the resolution is insufficient to define heterogeneity. We hypothesised that SSTR expression could be measured on circulating tumour cells (CTCs) and used to investigate heterogeneity of expression and track changes during therapy. METHODS: MCF-7 cells were transfected with SSTR2 or 5 and spiked into donor blood for analysis by CellSearch...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27871988/sonoporation-with-acoustic-cluster-therapy-act%C3%A2-induces-transient-tumour-volume-reduction-in-a-subcutaneous-xenograft-model-of-pancreatic-ductal-adenocarcinoma
#6
Spiros Kotopoulis, Endre Stigen, Mihaela Popa, Mireia Mayoral Safont, Andrew Healey, Svein Kvåle, Per Sontum, Bjørn Tore Gjertsen, Odd Helge Gilja, Emmet McCormack
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with survival averaging only 3months if untreated following diagnosis. A major limitation in effectively treating PDAC using conventional and targeted chemotherapeutic agents, is inadequate drug delivery to the target location, predominantly due to a poorly vascularised, desmoplastic tumour microenvironment. Ultrasound in combination with ultrasound contrast agents, i.e., microbubbles, that flow through the vasculature and capillaries can be used to disrupt such mechanical barriers, potentially allowing for a greater therapeutic efficacy...
November 18, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27871003/magnetic-mesoporous-nanospheres-anchored-with-lyp-1-as-an-efficient-pancreatic-cancer-probe
#7
Yongjian Jiang, Shaojun Liu, Yu Zhang, Hengchao Li, Hang He, Juntao Dai, Tao Jiang, Weihang Ji, Daoying Geng, Ahmed A Elzatahry, Abdulaziz Alghamdi, Deliang Fu, Yonghui Deng, Dongyuan Zhao
Immobilization of a ligand that selectively interacts with cancer cells to nanomaterials can enhance their diagnostic and therapeutic efficiency. In this study, we firstly demonstrate the high expression of receptor for cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) in both mouse and human pancreatic cancer. Based on these findings, sub-50 nm multifunctional superparamagnetic mesoporous nanospheres with surface modified with LyP-1 are rationally designed. Theses nanospheres have a core of silica-protected magnetite nanoparticle and a shell of FITC-labeled mesoporous silica, and they are able to specifically recognize and conjugate with the pancreatic cancer cell in vitro, as verified by the combined techniques of fluorescent imaging and T2 weight magnetic resonance imaging...
November 11, 2016: Biomaterials
https://www.readbyqxmd.com/read/27867166/the-usefulness-of-using-fiducial-marker-in-proton-therapy-for-locally-advanced-pancreatic-cancer
#8
Masakazu Shimizu, Takahiro Sato, Yoshihide Sawa, Kazuki Terashima, Toshihiro Yanou, Ryoji Ida
BACKGROUND: Though the dosimetric criteria for the gastrointestinal tract were met, late gastrointestinal toxicity was seen in several cases. Therefore, we thought that it was caused by the positional variation of gastrointestine surrounding pancreatic cancer because of peristalsis. METHOD: They were confirmed by CT image regularly. And we evaluated that how much the difference of matching methods for correcting the positional variation influenced dose distribution...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27866871/endoscopic-ultrasound-of-pancreatic-tumors
#9
M Wangermez
Computed tomography (CT) and endoscopic ultrasound (EUS) are the two most effective techniques for the assessment of pancreatic cancers. CT has revolutionized the field of tumor imaging in pancreatic cancer and is now a well-established imaging technique for diagnosis and staging. However, EUS still plays an important role in several situations, especially when the diagnosis is uncertain or when histopathological confirmation of the lesion is needed. Similarly, regarding cystic lesions, magnetic resonance imaging and CT have very good performances but are often inadequate because the diagnosis can be difficult to establish, while the consequences for the patient are major...
December 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27865283/management-of-locally-advanced-pancreatic-cancer
#10
REVIEW
Robert C G Martin
The diagnosis for locally advanced pancreatic cancer is based on high-quality cross-sectional imaging, which shows tumor invasion into the celiac/superior mesenteric arteries and/or superior mesenteric/portal venous system that is not reconstructable. The optimal management of these patients is evolving quickly with the advent of newer chemotherapeutics, radiation, and nonthermal ablation modalities. This article presents the current status of initial chemotherapy, surgical therapy, ablative therapy, and radiation therapy for patients with nonmetastatic locally advanced unresectable pancreatic cancer...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27865281/definition-and-management-of-borderline-resectable-pancreatic-cancer
#11
REVIEW
Jason W Denbo, Jason B Fleming
Patients with localized pancreatic ductal adenocarcinoma seek potentially curative treatment, but this group represents a spectrum of disease. Patients with borderline resectable primary tumors are a unique subset whose successful therapy requires a care team with expertise in medical care, imaging, surgery, medical oncology, and radiation oncology. This team must identify patients with borderline tumors then carefully prescribe and execute a combined treatment strategy with the highest possibility of cure...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27865276/endoscopic-evaluation-in-the-workup-of-pancreatic-cancer
#12
REVIEW
Ajaypal Singh, Ashley L Faulx
Early diagnosis and accurate staging of pancreatic cancer is very important to plan optimal management strategy. Endoscopy plays an important role in the diagnosis and management of pancreatic cancer. Endoscopic ultrasound imaging (EUS) is the most sensitive modality for diagnosis, especially for small pancreatic tumors; it also allows tissue acquisition for histological diagnosis. Computed tomography scanning and EUS play complementary roles in staging and are comparable in determining resectability. Endoscopic retrograde cholangiopancreatography allows tissue sampling but is limited to palliative biliary drainage in most cases...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27865275/imaging-evaluation-of-pancreatic-cancer
#13
REVIEW
Myra Kay Feldman, Namita Sharma Gandhi
Imaging studies are critical for the detection, characterization, initial staging, management, and monitoring of pancreatic cancer cases. Treatment of pancreatic cancer requires a multidisciplinary approach. Ideally, assessing resectablility with imaging and subsequent treatment decisions should be made at a high-volume center of excellence with a multidisciplinary team. This article reviews the major imaging modalities used to evaluate pancreatic neoplasms, with an emphasis on pancreatic imaging protocols...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27862278/diagnostic-efficacy-of-quantitative-endoscopic-ultrasound-elastography-for-differentiating-pancreatic-disease
#14
Su Young Kim, Jae Hee Cho, Yoon Jae Kim, Eui Joo Kim, Ji Young Park, Tae Joo Jeon, Yeon Suk Kim
BACKGROUND AND AIM: Endoscopic ultrasound elastography (EUS-EG) constitutes a novel imaging procedure that allows for the quantification of tissue stiffness with high degrees of accuracy in pancreatic disease. However, the optimal cutoff and reference strain ratio (SR) value of quantitative EUS-EG for differential diagnosis in patients with pancreatic disease remains unclear. This study aimed to clarify these values of normal pancreas, chronic pancreatitis, or pancreatic cancer in an Asian population...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27853829/-hepatopancreaticobiliary-diseases-in-igg4-associated-autoimmune-diseases
#15
L Grenacher
BACKGROUND: IgG4-related diseases are rare systemic multiorgan diseases and can thus affect any organ system. The incidence of diagnosis has significantly increased due to increasing awareness. OBJECTIVE: In the abdomen the hepatopancreaticobiliary system provides an essential organ system for the expression of IgG4-associated autoimmune diseases. The focus here is autoimmune pancreatitis type 1 but IgG4-associated sclerosing cholangitis and IgG4-associated hepatopathy, which can also occur in combination are less well-known...
November 16, 2016: Der Radiologe
https://www.readbyqxmd.com/read/27846432/functionalized-nanoparticles-enable-tracking-the-rapid-entry-and-release-of-doxorubicin-in-human-pancreatic-cancer-cells
#16
Maheshika P Arachchige, Suvra S Laha, Akshata R Naik, Kenneth T Lewis, Ratna Naik, Bhanu P Jena
Efficient drug delivery is critical to therapy. Using electron microscopy, X-ray, and light microscopy, we have characterized functionalized superparamagnetic iron oxide (SPIO) nanoparticles, and determined their ability for rapid entry and release of the cancer drug doxorubicin in human pancreatic cancer cells. Dextran-coated SPIO nanoparticle ferrofluid, functionalized with the red-autofluorescing doxorubicin and the green-fluorescent dye fluorescein isothiocyanate as a reporter, enables tracking the intracellular nanoparticle transport and drug release...
October 29, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27846136/prevalence-and-progression-of-pancreatic-cystic-precursor-lesions-differ-between-groups-at-high-risk-of-developing-pancreatic-cancer
#17
Ingrid C A W Konings, Femme Harinck, Jan-Werner Poley, Cora M Aalfs, Anja van Rens, Nanda C Krak, Anja Wagner, C Yung Nio, Rolf H Sijmons, Hendrik M van Dullemen, Frank P Vleggaar, Margreet G E M Ausems, Paul Fockens, Jeanin E van Hooft, Marco J Bruno
OBJECTIVES: The aim of this study was to compare the prevalence of cystic pancreatic lesions and their natural behavior in 2 distinct high-risk groups for developing pancreatic ductal adenocarcinoma (PDAC): (1) carriers of a mutation that predisposes to PDAC and (2) individuals without a known gene mutation but with a family history of PDAC (familial pancreatic cancer [FPC]). METHODS: Pancreatic surveillance by annual magnetic resonance imaging and endoscopic ultrasound was performed in individuals with an estimated lifetime risk of developing PDAC of 10% or greater...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27836618/a-new-classification-method-for-maldi-imaging-mass-spectrometry-data-acquired-on-formalin-fixed-paraffin-embedded-tissue-samples
#18
Tobias Boskamp, Delf Lachmund, Janina Oetjen, Yovany Cordero Hernandez, Dennis Trede, Peter Maass, Rita Casadonte, Jörg Kriegsmann, Arne Warth, Hendrik Dienemann, Wilko Weichert, Mark Kriegsmann
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) shows a high potential for applications in histopathological diagnosis, and in particular for supporting tumor typing and subtyping. The development of such applications requires the extraction of spectral fingerprints that are relevant for the given tissue and the identification of biomarkers associated with these spectral patterns. We propose a novel data analysis method based on the extraction of characteristic spectral patterns (CSPs) that allow automated generation of classification models for spectral data...
November 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27829085/assessment-of-a-revised-management-strategy-for-patients-with-intraductal-papillary-mucinous-neoplasms-involving-the-main-pancreatic-duct
#19
Motokazu Sugimoto, Irmina A Elliott, Andrew H Nguyen, Stephen Kim, V Raman Muthusamy, Rabindra Watson, O Joe Hines, David W Dawson, Howard A Reber, Timothy R Donahue
Importance: According to the 2012 International Consensus Guidelines, the diagnostic criterion of intraductal papillary mucinous neoplasms (IPMNs) involving the main duct (MD IPMNs) or the main and branch ducts (mixed IPMNs) of the pancreatic system is a main pancreatic duct (MPD) diameter of 5.0 mm or greater on computed tomography (CT) or magnetic resonance imaging (MRI). However, surgical resection is recommended for patients with an MPD diameter of 10.0 mm or greater, which is characterized as a high-risk stigma...
November 9, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27826200/a-current-perspective-on-stereotactic-body-radiation-therapy-for-pancreatic-cancer
#20
REVIEW
Julian C Hong, Brian G Czito, Christopher G Willett, Manisha Palta
Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or chemoradiation is associated with high rates of local tumor progression and metastases development, resulting in low survival rates. An emerging local modality is stereotactic body radiation therapy (SBRT), which uses image-guided, conformal, high-dose radiation...
2016: OncoTargets and Therapy
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