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Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai
The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated by its ability to form a homodimer. We have investigated the functional consequences of stabilised APP dimer expression in cells by studying the engineered dimerisation of the APPL17C (residue 17 in Aβ sequence) construct, which is associated with a 30% increase in APP dimer expression, on APP's neurite outgrowth promoting activity. Overexpression of APPL17C in SH-SY5Y cells decreased neurite outgrowth upon retinoic acid differentiation as compared to overexpressing APPWT cells...
April 19, 2018: Molecular Neurobiology
Benjamin Moulin, Olivier Chevallier, Gilles Abdulmalak, Maxime Luu, Marianne Latournerie, Anne Minello, Sophie Gehin, Jean-Pierre Cercueil, Marco Midulla, Romaric Loffroy
Background: To assess the association between final polytetrafluoroethylene (PTFE)-covered stent transjugular intrahepatic portosystemic shunt (TIPS) angiographic parameters and free shunt revision survey. Methods: Series of two comparison groups were generated with persistence of varices or not, the 25th , 50th , and 75th percentile as cutoff for each angle and a 15-mm distance as cutoff for distance D. Kaplan Meier free shunt revision curves were then created and compared with Log Rank test...
March 2018: Quantitative Imaging in Medicine and Surgery
Danielle L Schmitt, Anand Sundaram, Miji Jeon, Bao Tran Luu, Songon An
A macromolecular complex of the enzymes involved in human de novo purine biosynthesis, the purinosome, has been shown to consist of a core assembly to regulate the metabolic activity of the pathway. However, it remains elusive whether the core assembly itself can be selectively controlled in the cytoplasm without promoting the purinosome. Here, we reveal that pharmacological inhibition of the cytoplasmic activity of 3-phosphoinositide-dependent protein kinase 1 (PDK1) selectively promotes the formation of the core assembly, but not the purinosome, in cancer cells...
2018: PloS One
Ivan Lerner, Raphaël Veil, Dinh-Phong Nguyen, Vinh Phuc Luu, Rodolphe Jantzen
No abstract text is available yet for this article.
2018: Frontiers in Public Health
Joseph Daniel Pennington, Fritz C Eilber, Frederick R Eilber, Arun S Singh, Jarred P Reed, Bartosz Chmielowski, Jeffrey J Eckardt, Susan V Bukata, Nicholas M Bernthal, Noah Federman, Scott D Nelson, Sarah M Dry, Pin-Chieh Wang, Michael Luu, Michael T Selch, Michael L Steinberg, Anusha Kalbasi, Mitchell Kamrava
OBJECTIVES: The objective of this study was to analyze outcomes for patients with soft tissue sarcoma of the extremities using neoadjuvant ifosfamide-based chemotherapy and hypofractionated reduced dose radiotherapy, followed by limb-sparing surgery. MATERIALS AND METHODS: An Institutional Review Board (IRB)-approved retrospective review of patients treated at a single institution between 1990 and 2013 was performed. In total, 116 patients were identified who received neoadjuvant ifosfamide-based chemotherapy and 28 Gy in 8 fractions of preoperative radiation (equivalent dose in 2 Gray fractions, 31...
April 16, 2018: American Journal of Clinical Oncology
Huong Luu, Svetla Slavova, Patricia R Freeman, Michelle Lofwall, Steven Browning, Heather Bush
PURPOSE: Increased opioid analgesic prescribing (OAP) has been associated with increased risk of prescription opioid diversion, misuse, and abuse. We studied regional and rural-urban variations in OAP trends in Kentucky, from 2012 to 2015, and examined potential county-level risk and protective factors. METHODS: This study used prescription drug monitoring data. Marginal models employing generalized estimating equations were used to model repeated counts of residents with opioid analgesic prescriptions within county-quarter, 2012-2015, with offset for resident population, by rural-urban classification exposure, and adjusting for time-varying socioeconomic and relevant health status measures...
April 17, 2018: Journal of Rural Health
Benjamin C H Kwan, Rachel A McBain, Billy L Luu, Jane E Butler, Lynne E Bilston, Simon C Gandevia
METHODS: Twenty healthy subjects (10 males, age 28±5 years [mean ± SD]) lay supine, awake, with the head in a neutral position. Ventilation was monitored with inductance bands. Real-time B-mode ultrasound movies were analysed. We measured genioglossus motion (i) during spontaneous breathing, voluntary targeted breathing (normal tidal volume Vt), and voluntary hyperpnoea (at 1.5Vt and 2 Vt); (ii) during inspiratory flow resistive loading; (iii) with changes in end-expiratory lung volume (EELV)...
2018: PloS One
Tran Trung Luu, Valerio Scagnoli, Susmita Saha, Laura J Heyderman, Hans Jakob Wörner
Coherent extreme ultraviolet (EUV) radiation using high-harmonic generation (HHG) in α-quartz is demonstrated from 10 to 200 kHz, using 50 fs laser pulses at the center wavelength of 1030 nm. The EUV radiation extends beyond 25 eV in the nondamaging regime. The number of photons generated in a single harmonic order at 15.6 eV is measured to be ≈(3.5±2.5)×1010 per second which, to the best of our knowledge, is a first and record value reported to date using EUV HHG from solids. This Letter demonstrates one of the first all-solid-state EUV sources based on industrial-grade fiber lasers, enabling the possibility of bringing reliable EUV sources to the mass market...
April 15, 2018: Optics Letters
Thi Thu Huyen Chu, Thi Giang Hoang, Duy Chi Trinh, Charlotte Bureau, Donaldo Meynard, Aurore Vernet, Mathieu Ingouff, Nang Vinh Do, Christophe Périn, Emmanuel Guiderdoni, Pascal Gantet, Christophe Maurel, Doan-Trung Luu
BACKGROUND: Cell biology approach using membrane protein markers tagged with fluorescent proteins highlights the dynamic behaviour of plant cell membranes, not only in the standard but also in changing environmental conditions. In the past, this strategy has been extensively developed in plant models such as Arabidopsis. RESULTS: Here, we generated a set of transgenic lines expressing membrane protein markers to extend this approach to rice, one of the most cultivated crop in the world and an emerging plant model...
April 12, 2018: Rice
Lan Ngoc Pham, Boi Van Luu, Hung Duong Phuoc, Hanh Ngoc Thi Le, Hoa Thi Truong, Phuong Duc Luu, Masakazu Furuta, Kiyoshi Imamura, Yasuaki Maeda
Candlenut oil (CNO) is a potentially new feedstock for biodiesel (BDF) production. In this paper, a two-step co-solvent method for BDF production from CNO was examined. Firstly, esterification of free fatty acids (FFAs) (7 wt%) present in CNO was carried out using a co-solvent of acetonitrile (30 wt%) and H2 SO4 as a catalyst. The content of FFAs was reduced to 0.8 wt% in 1 h at 65°C. Subsequent transesterification of the crude oil produced was carried out using a co-solvent of acetone (20 wt%) and 1 wt% potassium hydroxide (KOH)...
April 9, 2018: Journal of Oleo Science
Carla J Abbott, David A X Nayagam, Chi D Luu, Stephanie B Epp, Richard A Williams, Cesar M Salinas-LaRosa, Joel Villalobos, Ceara McGowan, Mohit N Shivdasani, Owen Burns, Jason Leavens, Jonathan Yeoh, Alice A Brandli, Patrick C Thien, Jenny Zhou, Helen Feng, Chris E Williams, Robert K Shepherd, Penelope J Allen
Purpose: Following successful clinical outcomes of the prototype suprachoroidal retinal prosthesis, Bionic Vision Australia has developed an upgraded 44-channel suprachoroidal retinal prosthesis to provide a wider field of view and more phosphenes. The aim was to evaluate the preclinical passive safety characteristics of the upgraded electrode array. Methods: Ten normal-sighted felines were unilaterally implanted with an array containing platinum electrodes (44 stimulating and 2 returns) on a silicone carrier near the area centralis...
March 1, 2018: Investigative Ophthalmology & Visual Science
Loc Luu, Anh Dinh
The aim of this study is on the investigation of motion noise removal techniques using two-accelerometer sensor system and various placements of the sensors on gentle movement and walking of the patients. A Wi-Fi based data acquisition system and a framework on Matlab are developed to collect and process data while the subjects are in motion. The tests include eight volunteers who have no record of heart disease. The walking and running data on the subjects are analyzed to find the minimal-noise bandwidth of the SCG signal...
April 2, 2018: Sensors
Ilhwan Kim, Bong Sung Kim, Seunghoon Nam, Hoo-Jeong Lee, Ho Kyoon Chung, Sung Min Cho, Thi Hoai Thuong Luu, Seungmin Hyun, Chiwon Kang
Here, we fabricate poly(vinylidene fluoride- co -hexafluoropropene) (PVDF- co -HFP) by electrospinning for a gel polymer electrolyte (GPE) for use in flexible Li-ion batteries (LIBs). As a solvent, we use N -methyl-2-pyrrolidone (NMP), which helps produce the cross-linked morphology of PVDF- co -HFP separator, owing to its low volatility. The cross-linked PVDF- co -HFP separator shows an uptake rate higher than that of a commercialized polypropylene (PP) separator. Moreover, the PVDF- co -HFP separator shows an ionic conductivity of 2...
April 2, 2018: Materials
Nguyen Ngoc Cuong, Vu Dang Luu, Tran Anh Tuan, Le Tuan Linh, Kieu Dinh Hung, Vo Truong Nhu Ngoc, Kulbhushan Sharma, Van Huy Pham, Dinh-Toi Chu
OBJECTIVES: Digital subtractional angiography (DSA) is the standard method for diagnosis, assessment and management of arteriovenous malformation in the brain. Conventional DSA (cDSA) is an invasive imaging modality that is often indicated before interventional treatments (embolization, open surgery, gamma knife). Here, we aimed to compare this technique with a non-invasive MR angiography (MRI DSA) for brain arteriovenous malformation (bAVM). PATIENTS AND METHODS: Fourteen patients with ruptured brain AVM underwent embolization treatment pre-operation...
March 27, 2018: Clinical Neurology and Neurosurgery
Marianna S Sioson, Robert Martindale, Anuja Abayadeera, Nabil Abouchaleh, Dita Aditianingsih, Rungsun Bhurayanontachai, Wei-Chin Chiou, Naoki Higashibeppu, Mohd Basri Mat Nor, Emma Osland, Jose Emmanuel Palo, Nagarajan Ramakrishnan, Medhat Shalabi, Luu Ngan Tam, Jonathan Jit Ern Tan
BACKGROUND & AIMS: Guidance on managing the nutritional requirements of critically ill patients in the intensive care unit (ICU) has been issued by several international bodies. While these guidelines are consulted in ICUs across the Asia-Pacific and Middle East regions, there is little guidance available that is tailored to the unique healthcare environments and demographics across these regions. Furthermore, the lack of consistent data from randomized controlled clinical trials, reliance on expert consensus, and differing recommendations in international guidelines necessitate further expert guidance on regional best practice when providing nutrition therapy for critically ill patients in ICUs in Asia-Pacific and the Middle East...
April 2018: Clinical Nutrition ESPEN
A M Luu, K Meurer, T Herzog, W Uhl, C Braumann
BACKGROUND: Pancreatic injuries are rare in cases of blunt abdominal trauma and therefore easily misdiagnosed at time of hospital admission. They are associated with a significantly elevated morbidity and lethality. Bicycle handlebar injuries are the most common cause of pancreatic trauma in children and adolescents. CASE PRESENTATION: We report two cases of a 23-year-old Caucasian woman and a 15-year-old Caucasian boy who presented to our clinic with a similar history of a bicycle accident on 2 consecutive days...
March 26, 2018: Journal of Medical Case Reports
Nguyen Van Huy, You-Seon Nam, Nguyen Van Thanh, Ngo Tri Tuan, Nguyen Thi Thu Ha, Luu Ngoc Hoat, Nguyen Minh Hoang, Do Mai Hoa
The objective of this study was to assess the availability and readiness of the primary health care (PHC) services of commune health centers (CHCs) in Quoc Oai, a rural district of Northern Vietnam based on the World Health Organization's Service Availability and Readiness Assessment (SARA) tool. The study was done in 2 steps. First, the heads of the 21 CHCs of Quoc Oai district were interviewed using SARA, a quantitative survey, and the responses were then validated by direct observations of each facility...
January 2018: International Journal of Health Planning and Management
Vladimir Ljubojevic, Paul Luu, Patrick Robert Gill, Lee-Anne Beckett, Kaori Takehara-Nishiuchi, Eve De Rosa
A critical function of attention is to support a state of readiness to enhance stimulus detection, independent of stimulus modality. The nucleus basalis magnocellularis (NBM) is the major source of the neurochemical acetylcholine (ACh) for frontoparietal cortical networks thought to support attention. We examined a potential supramodal role of ACh in a frontoparietal cortical attentional network supporting target detection. We recorded local field potentials (LFP) in the prelimbic frontal (PFC) and the posterior parietal (PPC) cortices to assess whether ACh contributed to a state of readiness to alert rats to an impending presentation of visual or olfactory targets in one of five locations...
March 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Alvin W Li, Leah E Lalor, Fernanda Bellodi Schmidt, Minnelly Luu
Sclerodermatous graft-versus-host disease is a subtype of cutaneous chronic graft-versus-host disease that is characterized by sclerosis of the skin and subcutaneous tissue, resulting in debilitating contractures, among other life-threatening complications. Children with sclerodermatous graft-versus-host disease are at high risk of developing nonmelanoma skin cancer because of several risk factors, including young age at transplantation, prolonged immunosuppression, and exposure to photosensitizing antimicrobial prophylaxis such as voriconazole...
March 23, 2018: Pediatric Dermatology
Bui Thi Kim Anh, Nguyen Ngoc Minh, Nguyen Thi Hoang Ha, Dang Dinh Kim, Nguyen Trung Kien, Nguyen Quang Trung, Tran Thien Cuong, Luu Thai Danh
In field survey, Pteris vittata and Pityrogramma calomelanos were only found in arsenic (As) contaminated areas with soil pH 7.2-8.8 and 2.3-4.2, respectively. In the first pot experiment, two fern species were grown on the soil amended with 300 mg kg-1 As at soil pH of 5.1, 7.2 and 9. P. calomelanos survived all pH treatments, and had the highest frond As concentration and soil As removal efficiency at soil pH 5.1. All P. vittata plants were dead at soil pH 5.1. P. vittata had higher frond As concentration, biomass and the amount of As removed from the soil than those of P...
March 20, 2018: Bulletin of Environmental Contamination and Toxicology
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