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https://www.readbyqxmd.com/read/29236343/relationship-between-reticular-pseudodrusen-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration
#1
Chi Yun Doreen Ho, Jia Jia Lek, Khin Zaw Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
IMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their etiology remains unknown. RPD have been associated with reduced choroidal thickness but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness (ChT) and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study PARTICIPANTS: Participants were recruited from Centre for Eye Research Australia...
December 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29232088/comparing-the-affordable-care-act-s-financial-impact-on-safety-net-hospitals-in-states-that-expanded-medicaid-and-those-that-did-not
#2
Allen Dobson, Joan E DaVanzo, Randy Haught, Luu Phap-Hoa
Issue: Safety-net hospitals play a vital role in delivering health care to Medicaid enrollees, the uninsured, and other vulnerable patients. By reducing the number of uninsured Americans, the Affordable Care Act (ACA) was also expected to lower these hospitals’ significant uncompensated care costs and shore up their financial stability. Goal: To examine how the ACA’s Medicaid expansion affected the financial status of safety-net hospitals in states that expanded Medicaid and in states that did not...
November 1, 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/29225931/community-preferences-for-a-social-health-insurance-benefit-package-an-exploratory-study-among-the-uninsured-in-vietnam
#3
Hoa Thi Nguyen, Tinh Viet Luu, Gerald Leppert, Manuela De Allegri
Understanding public preferences in terms of health benefit packages (HBPs) remains limited, yet gathering community insights is an important endeavour when developing people-centred health systems and moving towards universal health coverage. Our study aimed to address this gap in knowledge by eliciting community preferences for the social health insurance benefit package among the uninsured in Vietnam. We adopted a mixed methods approach that included a ranking exercise followed by focus group discussions...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29208665/cognitive-trajectories-from-infancy-to-early-adulthood-in-the-epicure-cohort-time-to-refocus-research-on-how-to-break-the-natural-limits-of-brain-plasticity
#4
EDITORIAL
Thuy Mai Luu, Anne-Monique Nuyt
No abstract text is available yet for this article.
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29207549/9-vinylanthracene-based-fluorogens-synthesis-structure-property-relationships-and-applications
#5
Mengjie Liu, Sawaros Onchaiya, Lewis Yi Fong Tan, Mohammad A Haghighatbin, Tracey Luu, Tze Cin Owyong, Roozbeh Hushiarian, Conor F Hogan, Trevor A Smith, Yuning Hong
Fluorescent dyes with aggregation-induced emission (AIE) properties exhibit intensified emission upon aggregation. They are promising candidates to study biomolecules and cellular changes in aqueous environments when aggregation formation occurs. Here, we report a group of 9-position functionalized anthracene derivatives that were conveniently synthesized by the palladium-catalyzed Heck reaction. Using fluorometric analyses, these dyes were confirmed to show AIE behavior upon forming aggregates at high concentrations, in viscous solvents, and when poorly solubilized...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29206803/clinical-indicators-of-the-need-for-telemetry-postoperative-monitoring-in-patients-with-suspected-obstructive-sleep-apnea-undergoing-total-knee-arthroplasty
#6
Kethy M Jules-Elysée, Natasha A Desai, Yan Ma, Wei Zhang, Thuyvan H Luu, Stavros G Memtsoudis, Gregory A Liguori
BACKGROUND AND OBJECTIVES: Obstructive sleep apnea is associated with increased complication rates postoperatively. Current literature does not provide adequate guidance on management of these patients. This study used the STOP-Bang questionnaire to diagnose patients with possible obstructive sleep apnea (score ≥3). We hypothesized that a STOP-Bang score of 3 or greater would significantly correlate with the number of oxygen desaturation episodes during the first 48 hours after total knee arthroscopy...
December 4, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29205875/a-case-report-of-basic-calcium-phosphate-mimicking-septic-arthritis
#7
Queenie Luu, Siroos Nasibi, Praneal Sharma, Andrew Bonura, David Massasso
We report a case of a 53-year-old man who presented with a diagnostic dilemma mimicking septic arthritis. It is important to consider the diagnosis of calcific peri-arthritis clinically and recognize the hallmarks on radiograph and magnetic resonance imaging as this disease process resolves completely with conservative management like in our patient, and does not require operative intervention.
December 4, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29201606/a-3d-printed-implantable-device-for-voiding-the-bladder-using-shape-memory-alloy-sma-actuators
#8
Faezeh Arab Hassani, Wendy Yen Xian Peh, Gil Gerald Lasam Gammad, Roshini Priya Mogan, Tze Kiat Ng, Tricia Li Chuen Kuo, Lay Guat Ng, Percy Luu, Shih-Cheng Yen, Chengkuo Lee
Underactive bladder or detrusor underactivity (DU) is defined as a reduction of contraction strength or duration of the bladder wall. Despite the serious healthcare implications of DU, there are limited solutions for affected individuals. A flexible 3D printed implantable device driven by shape memory alloys (SMA) actuators is presented here for the first time to physically contract the bladder to restore voluntary control of the bladder for individuals suffering from DU. This approach is used initially in benchtop experiments with a rubber balloon acting as a model for the rat bladder to verify its potential for voiding, and that the operating temperatures are safe for the eventual implantation of the device in a rat...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29191797/web-based-intervention-to-teach-developmentally-supportive-care-to-parents-of-preterm-infants-feasibility-and-acceptability-study
#9
Thuy Mai Luu, Li Feng Xie, Perrine Peckre, Sylvana Cote, Thierry Karsenti, Claire-Dominique Walker, Julie Gosselin
BACKGROUND: Preterm birth affects 8% to 11% of the population and conveys a significant risk of developmental delays. Intervention programs that support child development have been shown to have a positive impact on early motor and cognitive development and on parental well-being. However, these programs are often difficult to implement in a real-life setting due to lack of resources. Hence, our multidisciplinary team developed Mieux Agir au Quotidien (MAQ) to teach developmentally supportive care to parents of preterm infants with the goal of improving child development and parental outcomes...
November 30, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29190704/electrocortical-correlates-of-human-level-ground-slope-and-stair-walking
#10
Trieu Phat Luu, Justin A Brantley, Sho Nakagome, Fangshi Zhu, Jose L Contreras-Vidal
This study investigated electrocortical dynamics of human walking across different unconstrained walking conditions (i.e., level ground (LW), ramp ascent (RA), and stair ascent (SA)). Non-invasive active-electrode scalp electroencephalography (EEG) signals were recorded and a systematic EEG processing method was implemented to reduce artifacts. Source localization combined with independent component analysis and k-means clustering revealed the involvement of four clusters in the brain during the walking tasks: Left and Right Occipital Lobe (LOL, ROL), Posterior Parietal Cortex (PPC), and Central Sensorimotor Cortex (SMC)...
2017: PloS One
https://www.readbyqxmd.com/read/29188271/a-rare-cause-of-small-bowel-ischemia
#11
Hubert Y Luu, Munveer S Bhangoo, Matthew Y C Lin
No abstract text is available yet for this article.
November 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29188136/fetal-zika-virus-infection-in-vietnam
#12
Phan Trong Lan, Luong Chan Quang, Vu Thi Que Huong, Nguyen Vu Thuong, Phan Cong Hung, Tran Thi Luu Nguyen Huong, Huynh Phuong Thao, Nguyen Thi Thanh Thao, Anthony W Mounts, Leisha D Nolen
As of 13 July 2016, 13 countries have reported fetal Zika virus (ZIKV) infection. Here we report a case of fetal ZIKV infection that resulted from an infection originating in Vietnam.
September 5, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29181565/postnatal-myocardium-remodelling-generates-inhomogeneity-in-the-architecture-of-the-ventricular-mass
#13
Pierre-Simon Jouk, Ba Luu Truong, Gabrielle Michalowicz, Yves Usson
BACKGROUND: The 3D architecture of the ventricular mass is poorly known, although in vivo imaging techniques show the physiological inhomogeneity of ventricular walls mechanics. Polarized light imaging makes it possible to quantitatively analyse the myosin filament orientation. AIMS: In this paper, we focus on the study the 3D architecture and regional isotropy of myocardial cells. METHODS: Twenty normal human hearts, 10 from the perinatal period and 10 from the post-neonatal period were studied by polarized light microscopy...
November 28, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29173183/a-comparison-of-fucoidan-conjugated-to-paclitaxel-and-curcumin-for-the-dual-delivery-of-cancer-therapeutic-agents
#14
Nam Hoang Phan, Thao Thanh Ly, Minh Nguyet Pham, Thinh Duc Luu, Toi Van Vo, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran
The aim of this study was to develop and compare polymeric micelles of fucoidan, a sulfated polysaccharide, and hydrophobic drugs such as paclitaxel and curcumin. Paclitaxel and curcumin are both known for their medicinal properties, including anticancer efficacy. However, their very low water solubility, absorption and rapid metabolism leads to reduced bioavailability. To redress these problems and enhance anti-cancer therapeutics using fucoidan, polymeric micelles were synthesized from conjugates of fucoidan and hydrophobic drugs...
November 21, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29144750/investigation-of-the-physical-and-bioactive-properties-of-bromo-and-iodo-containing-sponge-derived-compounds-possessing-an-oxyphenylethanamine-core
#15
Erin P McCauley, Hanh Lam, Nicholas Lorig-Roach, Justin Luu, Cameron Lloyd, Karen Tenney, Halina Pietraszkiewicz, Cristina Diaz, Frederick A Valeriote, Victoria Auerbuch, Phillip Crews
This research set out to identify compounds from marine sponges that can act as bacterial virulence blockers. Extracts from a total of 80 sponges collected from throughout Indonesia were screened in a high-throughput NF-κB-based screen that identifies compounds capable of inhibiting the bacterial type III secretion system (T3SS) in Yersinia pseudotuberculosis. An extract that was shown to inhibit T3SS-driven NF-κB expression was obtained from an Iotrochota cf. iota sponge and was the source of seven new bromo- and iodo-containing compounds, all of which contain a 2-(4-oxyphenyl)ethan-1-amine core...
November 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29115189/neuropsychological-feedback-services-improve-quality-of-life-and-social-adjustment
#16
Dana L Rosado, Susan Buehler, Emilie Botbol-Berman, Maia Feigon, Adeline León, Hien Luu, Carmen Carrión, Mitzi Gonzalez, Julia Rao, Taylor Grief, Michael Seidenberg, Neil H Pliskin
OBJECTIVE: In more recent years, studies have begun to examine levels of satisfaction of individuals or family members of individuals who undergo neuropsychological evaluation. However, to date there have been only a handful of formal studies that have specifically examined the role and contribution of neuropsychological assessment in patient care and management. This study sought to examine one specific component of neuropsychological assessment, namely the impact of patient feedback regarding neuropsychological testing on patient outcome...
November 8, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29104927/retrosynthetic-reaction-prediction-using-neural-sequence-to-sequence-models
#17
Bowen Liu, Bharath Ramsundar, Prasad Kawthekar, Jade Shi, Joseph Gomes, Quang Luu Nguyen, Stephen Ho, Jack Sloane, Paul Wender, Vijay Pande
We describe a fully data driven model that learns to perform a retrosynthetic reaction prediction task, which is treated as a sequence-to-sequence mapping problem. The end-to-end trained model has an encoder-decoder architecture that consists of two recurrent neural networks, which has previously shown great success in solving other sequence-to-sequence prediction tasks such as machine translation. The model is trained on 50,000 experimental reaction examples from the United States patent literature, which span 10 broad reaction types that are commonly used by medicinal chemists...
October 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29100787/facility-volume-and-survival-in-nasopharyngeal-carcinoma
#18
Emi J Yoshida, Michael Luu, John M David, Sungjin Kim, Alain Mita, Kevin Scher, Stephen L Shiao, Mourad Tighiouart, Nancy Y Lee, Allen S Ho, Zachary S Zumsteg
INTRODUCTION: Definitive treatment of nasopharyngeal carcinoma (NPC) is challenging owing to its rarity, complicated regional anatomy, and the intensity of therapy. In contrast to other head and neck cancers, the effect of facility volume has not been well described for NPC. METHODS AND MATERIALS: The National Cancer Database was queried for patients with stage II-IVB NPC diagnosed from 2004 to 2014 and treated with definitive radiation. Patients with incomplete staging, unknown receipt or timing of treatment, unknown follow-up duration, incomplete socioeconomic information, or treatment outside the reporting facility were excluded...
September 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29089185/cannula-based-drug-delivery-to-the-guinea-pig-round-window-causes-a-lasting-hearing-loss-that-may-be-temporarily-mitigated-by-bdnf
#19
Phillip J P Sale, Aaron Uschakov, Tasfia Saief, David P Rowe, Carla J Abbott, Chi D Luu, Amy J Hampson, Stephen J O'Leary, David J Sly
Sustained local delivery of drugs to the inner ear may be required for future regenerative and protective strategies. The round window is surgically accessible and a promising delivery route. To be viable, a delivery system should not cause hearing loss. This study determined the effect on hearing of placing a drug-delivery microcatheter on to the round window, and delivering either artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were monitored for 4 months after surgery, while the AP or BDNF was administered for the first month...
October 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29081317/evaluation-of-a-low-fidelity-ear-surgery-simulator-in-a-low-resource-setting
#20
K Luu, L Straatman, D Nakku, B Westerberg, N Carter, M Clark
OBJECTIVE: The provision of healthcare education in developing countries is a complex problem that simulation has the potential to help. This study aimed to evaluate the effectiveness of a low-cost ear surgery simulator, the Ear Trainer. METHODS: The Ear Trainer was assessed in two low-resource environments in Cambodia and Uganda. Participants were video-recorded performing four specific middle-ear procedures, and blindly scored using a validated measurement tool...
October 30, 2017: Journal of Laryngology and Otology
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