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https://www.readbyqxmd.com/read/29018441/very-early-onset-inflammatory-manifestations-of-x-linked-chronic-granulomatous-disease
#1
Roxane Labrosse, Jane Abou-Diab, Annaliesse Blincoe, Guilhem Cros, Thuy Mai Luu, Colette Deslandres, Martha Dirks, Laura Fazilleau, Philippe Ovetchkine, Pierre Teira, Françoise LeDeist, Isabel Fernandez, Fabien Touzot, Helene Decaluwe, Ugur Halac, Elie Haddad
Chronic granulomatous disease (CGD) is a rare primary immune deficiency caused by mutations in genes coding for components of the nicotinamide adenine dinucleotide phosphate oxidase, characterized by severe and recurrent bacterial and fungal infections, together with inflammatory complications. Dysregulation of inflammatory responses are often present in this disease and may lead to granulomatous lesions, most often affecting the gastrointestinal (GI) and urinary tracts. Treatment of inflammatory complications usually includes corticosteroids, whereas antimicrobial prophylaxis is used for infection prevention...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28993998/lithocholic-bile-acid-inhibits-lipogenesis-and-induces-apoptosis-in-breast-cancer-cells
#2
Trang H Luu, Jean-Marie Bard, Delphine Carbonnelle, Chloé Chaillou, Jean-Michel Huvelin, Christine Bobin-Dubigeon, Hassan Nazih
BACKGROUND: It has amply been documented that mammary tumor cells may exhibit an increased lipogenesis. Biliary acids are currently recognized as signaling molecules in the intestine, in addition to their classical roles in the digestion and absorption of lipids. The aim of our study was to evaluate the impact of lithocholic acid (LCA) on the lipogenesis of breast cancer cells. The putative cytotoxic effects of LCA on these cells were also examined. METHODS: The effects of LCA on breast cancer-derived MCF-7 and MDA-MB-231 cells were studied using MTT viability assays, Annexin-FITC and Akt phosphorylation assays to evaluate anti-proliferative and pro-apoptotic properties, qRT-PCR and Western blotting assays to assess the expression of the bile acid receptor TGR5 and the estrogen receptor ERα, and genes and proteins involved in apoptosis (Bax, Bcl-2, p53) and lipogenesis (SREBP-1c, FASN, ACACA)...
October 9, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28988808/impact-of-new-international-association-of-diabetes-and-pregnancy-study-groups-iadpsg-diagnostic-criteria-on-perinatal-outcomes-in-a-regional-tertiary-hospital-in-new-south-wales-australia
#3
Hong Lin Evelyn Tan, Judy Luu, Amanda Caswell, Elizabeth Holliday, John Attia, Shamasunder Acharya
AIMS: We compared the impact of new gestational diabetes (GDM) diagnostic criteria by IADPSG with previous criteria to ascertain concordance between the two criteria; and whether women discordant for GDM between the old and new criteria had increased pregnancy complications. METHODS: Oral glucose tolerance tests of pregnant women across time periods using old criteria and new criteria were collected. Maternal data and perinatal outcomes were compared between diagnostic concordant and discordant women...
October 6, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28983404/functional-heterogeneity-of-gut-resident-regulatory-t-cells
#4
REVIEW
Maik Luu, Ulrich Steinhoff, Alexander Visekruna
Regulatory T cells (Treg cells) have a central role in the maintenance of intestinal homeostasis by restraining inappropriate immune responses in the healthy gut. Although distinct intestinal immune cell populations have been described to exhibit regulatory activity, several genetic and functional studies provided a strong evidence for a pivotal role of forkhead box P3 (Foxp3)(+)CD4(+) Treg cells in prevention of dysregulated mucosal immune reactions and development of chronic immunological disorders such as celiac disease, food allergies and inflammatory bowel disease...
September 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28978694/identification-of-il-40-a-novel-b-cell-associated-cytokine
#5
Jovani Catalan-Dibene, Monica I Vazquez, Van Phi Luu, Sean-Paul Nuccio, Alborz Karimzadeh, Jenna M Kastenschmidt, S Armando Villalta, Irina Ushach, Egest J Pone, Paolo Casali, Manuela Raffatellu, Amanda M Burkhardt, Marcela Hernandez-Ruiz, Gina Heller, Peter A Hevezi, Albert Zlotnik
We describe a novel B cell-associated cytokine, encoded by an uncharacterized gene (C17orf99; chromosome 17 open reading frame 99), that is expressed in bone marrow and fetal liver and whose expression is also induced in peripheral B cells upon activation. C17orf99 is only present in mammalian genomes, and it encodes a small (∼27-kDa) secreted protein unrelated to other cytokine families, suggesting a function in mammalian immune responses. Accordingly, C17orf99 expression is induced in the mammary gland upon the onset of lactation, and a C17orf99(-/-) mouse exhibits reduced levels of IgA in the serum, gut, feces, and lactating mammary gland...
October 4, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28973367/imaging-lenticular-autofluorescence-in-older-subjects
#6
Jason Charng, Rose Tan, Chi D Luu, Sam Sadigh, Dwight Stambolian, Robyn H Guymer, Samuel G Jacobson, Artur V Cideciyan
Purpose: To evaluate whether a practical method of imaging lenticular autofluorescence (AF) can provide an individualized measure correlated with age-related lens yellowing in older subjects undergoing tests involving shorter wavelength lights. Methods: Lenticular AF was imaged with 488-nm excitation using a confocal scanning laser ophthalmoscope (cSLO) routinely used for retinal AF imaging. There were 75 older subjects (ages 47-87) at two sites; a small cohort of younger subjects served as controls...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28967053/multifaceted-aseptic-protocol-decreases-surgical-site-infections-following-hip-arthroplasty
#7
Ryan E Harold, Bennet A Butler, Joseph Lamplot, Hue H Luu, Cort D Lawton, David Manning
INTRODUCTION: We investigate the effectiveness of a comprehensive aseptic protocol in reducing surgical site infection (SSI) after hip arthroplasty in a single medical centre with a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA). METHODS: A prospectively collected database of all patients undergoing hip arthroplasty in a single centre between 2005 and 2011 was reviewed for SSI using Centers for Disease Control (CDC) criteria and AAOS guidelines...
September 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28962663/lineage-and-developmental-stage-specific-mechanomodulation-of-induced-pluripotent-stem-cell-differentiation
#8
Maricela Maldonado, Rebeccah J Luu, Gerardo Ico, Alex Ospina, Danielle Myung, Hung Ping Shih, Jin Nam
BACKGROUND: To maximize the translational utility of human induced pluripotent stem cells (iPSCs), the ability to precisely modulate the differentiation of iPSCs to target phenotypes is critical. Although the effects of the physical cell niche on stem cell differentiation are well documented, current approaches to direct step-wise differentiation of iPSCs have been typically limited to the optimization of soluble factors. In this regard, we investigated how temporally varied substrate stiffness affects the step-wise differentiation of iPSCs towards various lineages/phenotypes...
September 29, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28956187/phase-ib-trial-of-ixabepilone-and-vorinostat-in-metastatic-breast-cancer
#9
Thehang Luu, Kyu-Pyo Kim, Suzette Blanchard, Bean Anyang, Arti Hurria, Lixin Yang, Jan H Beumer, George Somlo, Yun Yen
PURPOSE: To translate promising preclinical data on the combination of vorinostat and ixabepilone for metastatic breast cancer (MBC) into clinical trials. METHODS: We conducted a randomized two-arm Phase IB clinical trial of ascending doses of vorinostat and ixabepilone in prior -treated MBC patients. To determine the maximum tolerated dose (MTD), 37 patients were randomized to schedule A: every-3-week ixabepilone + vorinostat (days 1-14), or schedule B: weekly ixabepilone + vorinostat (days 1-7; 15-21) Pharmacokinetics were assessed...
September 27, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28940037/satellite-cell-activation-and-mtor-signaling-pathway-response-to-resistance-and-combined-exercise-in-elite-weight-lifters
#10
Chang Hyun Lim, Thien Suong Luu, Le Quy Phoung, Tae Seok Jeong, Chang Keun Kim
PURPOSE: Our aim was to compare the effects of a single exercise training mode (resistance exercise) with a combined exercise training (resistance and plyometric exercise) mode on satellite cell activity and anabolic signaling at the molecular level. METHODS: Eighteen male weight lifters (20 ± 4 years, BMI 27 ± 6 kg/m(2)) were randomly assigned to either a series of resistance exercise or a series of combined exercise group. The intensity of the exercise was set at 60% of their 1 RM weight and subjects completed three sets each of six repetitions...
November 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28935232/utilising-physiological-principles-of-motor-unit-recruitment-to-reduce-fatigability-of-electrically-evoked-contractions-a-narrative-review
#11
Trevor S Barss, Emily N Ainsley, Francisca C Claveria-Gonzalez, M John Luu, Dylan J Miller, Matheus J Wiest, David F Collins
Neuromuscular electrical stimulation (NMES) is used to produce contractions to restore movement and reduce secondary complications for individuals experiencing motor impairment. NMES is conventionally delivered through a single pair of electrodes over a muscle belly or nerve trunk using short pulse durations and frequencies between 20-40 Hz (conventional NMES). Unfortunately, the benefits and widespread use of conventional NMES are limited by contraction fatigability, which is due in large part to the non-physiological way that contractions are generated...
September 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28906146/new-cerebroside-and-chondrocyte-proliferation-activity-of-caryota-mitis-l
#12
Pham Thi Nhat Trinh, Nguyen Thi To Quynh, Mai Dinh Tri, Phan Nhat Minh, Nguyen Thi Le Thuy, Luu Hong Truong, Nguyen Ngoc Tuan, Le Tien Dung
Caryota mitis L., a flowering plant, belongs to the family Arecaceae. In Vietnam, its fruits were used to treat joint pain. The present study was designed to investigate the phytochemicals and chondrocyte proliferation activity of C. mitis L. fruits on young human chondrocyte. The results showed that all of extracts (crude extract as well as n-hexane, chloroform, ethyl acetate and methanol fractions) were stimulated the growth of chondrocyte at 0.1 μg/mL; 0.01 μg/mL concentrations, of which the n-hexane and methanol fractions significantly increased the proliferation of chondrocyte by 30...
September 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28894447/the-microbial-metabolite-butyrate-induces-expression-of-th1-associated-factors-in-cd4-t-cells
#13
Meike Kespohl, Niyati Vachharajani, Maik Luu, Hani Harb, Sabine Pautz, Svenja Wolff, Nina Sillner, Alesia Walker, Philippe Schmitt-Kopplin, Thomas Boettger, Harald Renz, Stefan Offermanns, Ulrich Steinhoff, Alexander Visekruna
Short-chain fatty acids (SCFAs), which are generated by the bacterial fermentation of dietary fibers, promote expansion of regulatory T cells (Tregs). Potential therapeutic value of SCFAs has been recently highlighted in the experimental models of T cell-mediated autoimmunity and allergic inflammation. These studies suggest that physiological intestinal concentrations of SCFAs within the millimolar range are crucial for dampening inflammation-mediated processes. Here, we describe opposing effects of SCFAs on T cell-mediated immune responses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28881833/lncrna-h19-mediates-bmp9-induced-osteogenic-differentiation-of-mesenchymal-stem-cells-mscs-through-notch-signaling
#14
Junyi Liao, Xinyi Yu, Xue Hu, Jiaming Fan, Jing Wang, Zhicai Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Ruyi Zhang, Shujuan Yan, Yasha Li, Wenwen Zhang, Jing Cui, Chao Ma, Li Li, Yichun Yu, Tingting Wu, Xingye Wu, Jiayan Lei, Jia Wang, Chao Yang, Ke Wu, Ying Wu, Jun Tang, Bai-Cheng He, Zhong-Liang Deng, Hue H Luu, Rex C Haydon, Russell R Reid, Michael J Lee, Jennifer Moriatis Wolf, Wei Huang, Tong-Chuan He
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can undergo self-renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a well-orchestrated process and regulated by multiple signaling pathways. We previously demonstrated that BMP9 is one of the most potent osteogenic factors. However, molecular mechanism through which BMP9 governs osteoblastic differentiation remains to be fully understood. Increasing evidence indicates noncoding RNAs (ncRNAs) may play important regulatory roles in many physiological and/or pathologic processes...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881761/transcription-factor-c-rel-is-indispensable-for-generation-of-thymic-but-not-of-peripheral-foxp3-regulatory-t-cells
#15
Maik Luu, Elena Jenike, Niyati Vachharajani, Alexander Visekruna
The transcription factor c-Rel has been shown to be crucial for development of regulatory T cells (Tregs). Recent studies have reported that the expression of transcription factor Helios in Foxp3(+) Tregs correlates with thymic origin of these cells (tTregs). Notably, we found that only the Helios(+)Foxp3(+) Treg cell population was substantially reduced in c-Rel deficient mice. In contrast to a defective tTreg development, we observed an expansion of mucosal Tregs during the induction of acute colitis in rel(-/-) mice...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881574/prevention-of-colitis-associated-cancer-by-selective-targeting-of-immunoproteasome-subunit-lmp7
#16
Niyati Vachharajani, Thorsten Joeris, Maik Luu, Sabrina Hartmann, Sabine Pautz, Elena Jenike, Georgios Pantazis, Immo Prinz, Markus J Hofer, Ulrich Steinhoff, Alexander Visekruna
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome has been extensively analyzed in the context of inflammation and infectious diseases. Here, we show that the proteasomal immunosubunit LMP7 plays an essential role in development of CAC. Mice devoid of LMP7 were resistant to chronic inflammation and formation of neoplasia, and developed virtually no tumors after AOM/DSS treatment...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880455/automated-cell-counts-on-csf-samples-a-multicenter-performance-evaluation-of-the-glocyte-system
#17
E A Hod, C Brugnara, M Pilichowska, L M Sandhaus, H S Luu, S K Forest, J C Netterwald, G M Reynafarje, A Kratz
OBJECTIVES: Automated cell counters have replaced manual enumeration of cells in blood and most body fluids. However, due to the unreliability of automated methods at very low cell counts, most laboratories continue to perform labor-intensive manual counts on many or all cerebrospinal fluid (CSF) samples. This multicenter clinical trial investigated if the GloCyte System (Advanced Instruments, Norwood, MA), a recently FDA-approved automated cell counter, which concentrates and enumerates red blood cells (RBCs) and total nucleated cells (TNCs), is sufficiently accurate and precise at very low cell counts to replace all manual CSF counts...
September 7, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28878324/regional-genetic-diversity-for-nnv-grouper-viruses-across-the-indo-asian-region-implications-for-selecting-virus-resistance-in-farmed-groupers
#18
Wayne Knibb, Giang Luu, H K A Premachandra, Ming-Wei Lu, Nguyen Hong Nguyen
Grouper aquaculture around Asia is impacted by the nervous necrosis virus (NNV) and, in response, host resistance to this infection is being considered as a trait for selection. However efficient selection may be confounded if there are different genetic strains of NNV within and between regions and over years. This study uses statistical approaches and assessment of "characteristic attributes" (i.e. nucleotide positions that discriminate among strains) to assess whether published and new NNV RNA2 cds sequences show genetic differentiation over geography, host species and years...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877797/liver-metastases-10-years-after-resection-of-a-benign-insulinoma
#19
Andreas Minh Luu, Torsten Herzog, Waldemar Uhl, Chris Braumann
No abstract text is available yet for this article.
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28869566/dramatic-influence-of-ionic-liquid-and-ultrasound-irradiation-on-the-electrophilic-sulfinylation-of-aromatic-compounds-by-sulfinic-esters
#20
Ngoc-Lan Thi Nguyen, Hong-Thom Vo, Fritz Duus, Thi Xuan Thi Luu
The sulfinylation reaction of aromatic and hetero-aromatic compounds with sulfinic esters as electrophiles has been investigated in different ionic liquids and by means of different Lewis acid salts in order to get moderate to good yields of asymmetrical sulfoxides. Mixtures of 1-butyl-3-methylimidazolium chloride and aluminum chloride were found to be the most efficient and recyclable reaction framework. Ultrasound sonication appeared to be the most useful and green activation method to afford the sulfoxides in yields better than or equivalent to those obtained under the longer-lasting conventional stirring conditions...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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