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https://www.readbyqxmd.com/read/28640546/treatment-at-high-volume-facilities-and-academic-centers-is-independently-associated-with-improved-survival-in-patients-with-locally-advanced-head-and-neck-cancer
#1
John M David, Allen S Ho, Michael Luu, Emi J Yoshida, Sungjin Kim, Alain C Mita, Kevin S Scher, Stephen L Shiao, Mourad Tighiouart, Zachary S Zumsteg
BACKGROUND: The treatment of head and neck cancers is complex and associated with significant morbidity, requiring multidisciplinary care and physician expertise. Thus, facility characteristics, such as clinical volume and academic status, may influence outcomes. METHODS: The current study included 46,567 patients taken from the National Cancer Data Base who were diagnosed with locally advanced invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx and were undergoing definitive radiotherapy...
June 22, 2017: Cancer
https://www.readbyqxmd.com/read/28638571/prevalence-of-qt-prolongation-and-associated-lvef-changes-in-diabetic-patients-over-a-four-year-retrospective-time-period
#2
Zhongju Lu, Lloyd Lense, Mohit Sharma, Ankit Shah, Ying Luu, Lucien Cardinal, Joan Faro, Alan Kaell
Aim: To evaluate the prevalence and longitudinal changes of prolonged QTc in DM patients admitted to our community hospital, and to determine, if any, its correlation with changes of left ventricular ejection fraction (LVEF). Methods: A retrospective chart review of patients with Type 1 (T1DM) and Type 2 (T2DM) with at least two admissions during a four-year period was performed to identify QTc interval, and LVEF, as measured on transthoracic echocardiogram. Changes in QTc and LVEF between patient hospital admissions were compared...
March 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28623522/h3-k27m-mutations-are-extremely-rare-in-posterior-fossa-group-a-ependymoma
#3
Scott Ryall, Miguel Guzman, Samer K Elbabaa, Betty Luu, Stephen C Mack, Michal Zapotocky, Michael D Taylor, Cynthia Hawkins, Vijay Ramaswamy
BACKGROUND: Mutations in the tail of histone H3 (K27M) are frequently found in pediatric midline high-grade glioma's but have rarely been reported in other malignancies. Recently, recurrent somatic nucleotide variants in histone H3 (H3 K27M) have been reported in group A posterior fossa ependymoma (EPN_PFA), an entity previously described to have no recurrent mutations. However, the true incidence of H3 K27M mutations in EPN_PFA is unknown. METHODS: In order to discern the frequency of K27M mutations in histone H3 in EPN_PFA, we analyzed 151 EPN_PFA previously profiled with genome-wide methylation arrays using a validated droplet digital PCR assay...
June 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28619952/cardiometabolic-correlates-of-sleep-disordered-breathing-in-andean-highlanders
#4
Luu V Pham, Catherine H Miele, Noah G Schwartz, Rafael S Arias, Adi Rattner, Robert H Gilman, J Jaime Miranda, Vsevolod Y Polotsky, William Checkley, Alan R Schwartz
Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders.We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose, homeostatic model-based assessments of insulin resistance and β-cell function (HOMA-IR and HOMA-β, respectively), blood pressure, and lipids, while adjusting for age, sex, body mass index (BMI) and wake oxygenation...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28619849/the-house-fly-y-chromosome-is-young-and-minimally-differentiated-from-its-ancient-x-chromosome-partner
#5
Richard P Meisel, Christopher A Gonzales, Hoang Luu
Canonical ancient sex chromosome pairs consist of a gene rich X (or Z) chromosome and a male- (or female-) limited Y (or W) chromosome that is gene poor. In contrast to highly differentiated sex chromosomes, nascent sex chromosome pairs are homomorphic or very similar in sequence content. Nascent sex chromosomes can arise if an existing sex chromosome fuses to an autosome or an autosome acquires a new sex-determining locus/allele. Sex chromosomes often differ between closely related species and can even be polymorphic within species, suggesting that nascent sex chromosomes arise frequently over the course of evolution...
June 15, 2017: Genome Research
https://www.readbyqxmd.com/read/28609888/a-new-karst-dwelling-species-of-the-gekko-japonicus-group-squamata-gekkonidae-from-central-laos
#6
Vinh Quang Luu, Truong Quang Nguyen, Minh Duc Le, Michael Bonkowski, Thomas Ziegler
A new species of the Gekko japonicus group is described from Khammouane Province, central Laos, based on morphological characters and molecular data. Morphologically, Gekko nadenensis sp. nov. is differentiated from the remaining congeners by a combination of the following characters: size moderate (SVL 61.0-77.1 mm); nares bordered with rostral; internasals absent; postmentals enlarged; interorbital scales between anterior corners of the eyes 28-30; dorsal tubercles absent; ventral scales between mental and cloacal slit 175-185; midbody scale rows 123-140; ventral scale rows 38-40; subdigital lamellae on first toes 13-15, on fourth toes 14-16; finger and toe webbing present at base; tubercles on dorsal surface of fore and hind limbs absent; precloacal pores six (3+3 or 5+1) in a discontinuous row in males, absent in the female; postcloacal tubercles 1 or 2; tubercles absent on dorsal surface of tail base; subcaudals distinctly enlarged; dorsal surface of body with greyish brown blotches...
May 8, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609654/intertumoral-heterogeneity-within-medulloblastoma-subgroups
#7
Florence M G Cavalli, Marc Remke, Ladislav Rampasek, John Peacock, David J H Shih, Betty Luu, Livia Garzia, Jonathon Torchia, Carolina Nor, A Sorana Morrissy, Sameer Agnihotri, Yuan Yao Thompson, Claudia M Kuzan-Fischer, Hamza Farooq, Keren Isaev, Craig Daniels, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee, Wieslawa A Grajkowska, Marta Perek-Polnik, Alexandre Vasiljevic, Cecile Faure-Conter, Anne Jouvet, Caterina Giannini, Amulya A Nageswara Rao, Kay Ka Wai Li, Ho-Keung Ng, Charles G Eberhart, Ian F Pollack, Ronald L Hamilton, G Yancey Gillespie, James M Olson, Sarah Leary, William A Weiss, Boleslaw Lach, Lola B Chambless, Reid C Thompson, Michael K Cooper, Rajeev Vibhakar, Peter Hauser, Marie-Lise C van Veelen, Johan M Kros, Pim J French, Young Shin Ra, Toshihiro Kumabe, Enrique López-Aguilar, Karel Zitterbart, Jaroslav Sterba, Gaetano Finocchiaro, Maura Massimino, Erwin G Van Meir, Satoru Osuka, Tomoko Shofuda, Almos Klekner, Massimo Zollo, Jeffrey R Leonard, Joshua B Rubin, Nada Jabado, Steffen Albrecht, Jaume Mora, Timothy E Van Meter, Shin Jung, Andrew S Moore, Andrew R Hallahan, Jennifer A Chan, Daniela P C Tirapelli, Carlos G Carlotti, Maryam Fouladi, José Pimentel, Claudia C Faria, Ali G Saad, Luca Massimi, Linda M Liau, Helen Wheeler, Hideo Nakamura, Samer K Elbabaa, Mario Perezpeña-Diazconti, Fernando Chico Ponce de León, Shenandoah Robinson, Michal Zapotocky, Alvaro Lassaletta, Annie Huang, Cynthia E Hawkins, Uri Tabori, Eric Bouffet, Ute Bartels, Peter B Dirks, James T Rutka, Gary D Bader, Jüri Reimand, Anna Goldenberg, Vijay Ramaswamy, Michael D Taylor
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28600842/a-scoping-review-of-epidemiologic-risk-factors-for-pediatric-obesity-implications-for-future-childhood-obesity-and-dental-caries-prevention-research
#8
Donald L Chi, Monique Luu, Frances Chu
RESEARCH QUESTIONS: What are the non-modifiable (socioeconomic, genetic) and modifiable factors (physical activity, dietary behaviors) related to childhood (under age 12) obesity? How can this knowledge be applied to oral health professionals' efforts to prevent or manage dental caries in children? OBJECTIVES: Studies have identified risk factors for childhood obesity. The purpose of this scoping review was to develop a conceptual model to identify non-modifiable and modifiable risk factors for childhood obesity and to illustrate how these findings are relevant in developing interventions aimed at preventing obesity and dental caries in children...
June 10, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28600237/a-flexure-guided-piezo-drill-for-penetrating-the-zona-pellucida-of-mammalian-oocytes
#9
Wesley Johnson, Changsheng Dai, Jun Liu, Xian Wang, Devin K Luu, Zhuoran Zhang, Changhai Ru, Chao Zhou, Min Tan, Huayan Pu, Shaorong Xie, Yan Peng, Jun Luo, Yu Sun
Mammalian oocytes such as mouse oocytes have a highly elastic outer membrane, zona pellucida (ZP) that cannot be penetrated without significantly deforming the oocyte, even with a sharp micropipette. Piezo drill devices leverage lateral and axial vibration of the micropipette to accomplish ZP penetration with greatly reduced oocyte deformation. However, existing piezo drills all rely on a large lateral micropipette vibration amplitude (>20 μm ) and a small axial vibration amplitude (<0.1 μm ). The very large lateral vibration amplitude has been deemed to be necessary for ZP penetration although it also induces larger oocyte deformation and more oocyte damage...
June 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28595341/obstructive-sleep-apnea-dynamically-increases-nocturnal-plasma-free-fatty-acids-glucose-and-cortisol-during-sleep
#10
Swati Chopra, Aman Rathore, Haris Younas, Luu V Pham, Chenjuan Gu, Aleksandra Beselman, Il-Young Kim, Robert R Wolfe, Jamie Perin, Vsevolod Y Polotsky, Jonathan C Jun
Context: Obstructive sleep apnea (OSA) is associated with diabetes and cardiovascular disease. This association may be related to metabolic changes that transpire during sleep in OSA. Objective: To examine the impact of OSA, elicited by cessation of continuous positive airway pressure (CPAP), on frequently sampled nocturnal metabolic markers including plasma free fatty acids (FFA), glucose, insulin, triglycerides, cortisol, and lactate; as well as glucose production, oral glucose tolerance, blood pressure, endothelial function, cholesterol, and high sensitivity C-reactive protein (hsCRP)...
June 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28589449/surprising-twist-in-the-plot-sister-mary-joseph-s-nodule-of-pancreatic-cancer-mimicking-wound-infection-after-umbilical-hernia-repair
#11
Andreas M Luu, K Meurer, T Herzog, J Munding, W Uhl, C Braumann
No abstract text is available yet for this article.
June 6, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28559409/association-of-pre-chemotherapy-peripheral-blood-pro-inflammatory-and-coagulation-factors-with-physical-function-in-women-with-breast-cancer
#12
Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, David Smith, Joanne Mortimer, The-Hang Luu, George Somlo, James Waisman, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Tao Feng, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria
BACKGROUND: Pro-inflammatory and coagulation factors serve as biomarkers of aging and functional reserve. The purpose of this study was to determine if pro-inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]), and coagulation (D-dimer) factors were associated with pre-chemotherapy functional status in women with stage I-III breast cancer. PATIENTS AND METHODS: Prior to chemotherapy initiation in patients with stage I-III breast cancer, the following was captured: IL-6, CRP, D-dimer blood levels, and physical function measures including activities of daily living (ADL, subscale of Medical Outcomes Study Physical Health); instrumental activities of daily living (IADL, subscale of the Older Americans Resources and Services Program); Timed Up and Go (TUG); physician-rated Karnofsky Performance Status (KPS); and self-rated KPS...
May 30, 2017: Oncologist
https://www.readbyqxmd.com/read/28551090/role-of-robotic-surgery-in-treating-fibroids-and-benign-uterine-mass
#13
REVIEW
Suejin Kim, Thanh Ha Luu, Natalia Llarena, Tommaso Falcone
Fibroid uterus can be managed medically, surgically, or through non-extirpative procedures, depending on the clinical situation. Myomectomy may be beneficial, especially to those desiring to preserve the uterus and/or fertility, with outcomes comparable to those of hysterectomy, with a laparoscopic approach being favored when feasible. For definitive therapy, hysterectomy can be pursued where the surgical approach should be individualized. Comparison of robotic-assisted laparoscopic approach shows that the robotic approach may be favored for cases with higher complexity and multiple fibroids in myomectomy; however, no clear advantage is seen with hysterectomy at this time, necessitating further research in the area of robotics for hysterectomy in benign uterine mass treatment to justify the cost...
April 23, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28541677/binary-solvent-extraction-of-tocols-%C3%AE-oryzanol-and-ferulic-acid-from-rice-bran-using-alkaline-treatment-combined-with-ultrasonication
#14
Hoa Thi Truong, Phuong Duc Luu, Kiyoshi Imamura, Takeo Matsubara, Hideki Takahashi, Norimichi Takenaka, Luu Van Boi, Yasuaki Maeda
Alkaline treatment (Alk) combined with ultrasound-assisted extraction (UAE) (Alk+UAE) was examined as a means of extracting tocols and γ-oryzanol from rice bran into an organic phase while simultaneously recovering ferulic acid into an aqueous phase. The tocols and γ-oryzanol/ferulic acid yields were determined using high-performance liquid chromatography with fluorescence and UV detection. The effects of extraction conditions were evaluated by varying the Alk treatment temperature and extraction duration...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28533700/risk-management-and-regulations-for-lower-limb-medical-exoskeletons-a-review
#15
REVIEW
Yongtian He, David Eguren, Trieu Phat Luu, Jose L Contreras-Vidal
Gait disability is a major health care problem worldwide. Powered exoskeletons have recently emerged as devices that can enable users with gait disabilities to ambulate in an upright posture, and potentially bring other clinical benefits. In 2014, the US Food and Drug Administration approved marketing of the ReWalk™ Personal Exoskeleton as a class II medical device with special controls. Since then, Indego™ and Ekso™ have also received regulatory approval. With similar trends worldwide, this industry is likely to grow rapidly...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28510318/report-from-the-american-society-of-transplantation-conference-on-donor-heart-selection-in-adult-cardiac-transplantation-in-the-u-s
#16
J Kobashigawa, K Khush, M Colvin, M Acker, A Van Bakel, H Eisen, Y Naka, J Patel, D A Baran, T Daun, M Luu, M Olymbios, J Rogers, V Jeevanandam, F Esmailian, F D Pagani, B Lima, J Stehlik
Cardiac transplantation remains the only definitive treatment for end-stage heart failure. Transplantation rates are limited by a shortage of donor hearts. This shortage is magnified because many hearts are discarded due to strict selection criteria and concern for regulatory reprimand for less than optimal post-transplant outcomes. There is no standardized approach to donor selection despite proposals to liberalize acceptance criteria. A donor heart selection conference was organized to facilitate discussion, and generate ideas for future research...
May 16, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28498510/semi-automated-registration-of-pre-and-intra-operative-ct-for-image-guided-percutaneous-liver-tumor-ablation-interventions
#17
Gokhan Gunay, Manh Ha Luu, Adriaan Moelker, Theo van Walsum, Stefan Klein
PURPOSE: In CT guided liver tumor ablation interventions, registration of a preoperative contrast enhanced CT image to the intra-operative CT image is hypothesized to improve guidance. This is a highly challenging registration task due to differences in patient poses and large deformations, and therefore high registration errors are expected. In this study, our objective is to develop a method that enables users to locally improve the registration where the registration fails, with minimal user interaction...
May 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28493476/first-report-on-free-and-covalently-bound-microcystins-in-fish-and-bivalves-from-vietnam-assessment-of-risks-to-humans
#18
Thanh-Luu Pham, Kazuya Shimizu, Thanh-Son Dao, Utsumi Motoo
The free and covalently bound microcystins (MCs) in 3 fish and 2 bivalves from the Dau Tieng Reservoir in Vietnam were investigated for the first time in the present study. The results showed that all species were contaminated with MCs. Our findings indicate that eating the muscle of fish from the Dau Tieng Reservoir is safe but that eating the bivalves is not safe during toxic cyanobacterial bloom episodes. Environ Toxicol Chem 2017;9999:1-5. © 2017 SETAC.
May 11, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28491933/wnt-and-bmp-signaling-crosstalk-in-regulating-dental-stem-cells-implications-in-dental-tissue-engineering
#19
Fugui Zhang, Jinglin Song, Hongmei Zhang, Enyi Huang, Dongzhe Song, Viktor Tollemar, Jing Wang, Jinhua Wang, Maryam Mohammed, Qiang Wei, Jiaming Fan, Junyi Liao, Yulong Zou, Feng Liu, Xue Hu, Xiangyang Qu, Liqun Chen, Xinyi Yu, Hue H Luu, Michael J Lee, Tong-Chuan He, Ping Ji
Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling. Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance, essential oral functions and the quality of life. Regenerative dentistry holds great promise in treating oral/dental disorders. The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells, along with the signaling mechanisms governing stem cell self-renewal and differentiation...
December 2016: Genes & Diseases
https://www.readbyqxmd.com/read/28486614/potential-role-of-dna-methylation-as-a-facilitator-of-target-search-processes-for-transcription-factors-through-interplay-with-methyl-cpg-binding-proteins
#20
Catherine A Kemme, Rolando Marquez, Ross H Luu, Junji Iwahara
Eukaryotic genomes contain numerous non-functional high-affinity sequences for transcription factors. These sequences potentially serve as natural decoys that sequester transcription factors. We have previously shown that the presence of sequences similar to the target sequence could substantially impede association of the transcription factor Egr-1 with its targets. In this study, using a stopped-flow fluorescence method, we examined the kinetic impact of DNA methylation of decoys on the search process of the Egr-1 zinc-finger protein...
May 9, 2017: Nucleic Acids Research
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