keyword
https://read.qxmd.com/read/38546135/heterogeneity-of-coronary-vascular-function-and-myocardial-oxygenation-in-women-with-angina-and-non-obstructive-coronary-artery-disease
#1
JOURNAL ARTICLE
Elizabeth Hillier, Malik Elharram, James A White, Todd Anderson, Judy Luu, Dina Labib, Muhammad Alhussein, Matthias G Friedrich, Louise Pilote
AIMS: Women with angina and non-obstructive coronary artery disease (ANOCA) have a heightened risk for cardiovascular events, and the pathophysiology for ischemic symptoms may be related to alterations in microvascular structure and function. We examined the use of breathing-enhanced oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) using vasoactive breathing maneuvers to assess myocardial oxygenation in women with ANOCA. METHODS AND RESULTS: We recruited women (aged 40-65 years) from two sites in Canada who presented to healthcare with persistent retrosternal chest pain and found to have ANOCA, or without a history of cardiovascular disease...
March 28, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38546071/identification-of-hub-genes-and-potential-pathogenesis-in-gastric-cancer-based-on-integrated-gene-expression-profile-analysis
#2
JOURNAL ARTICLE
Hung Luu Truong Thanh, Tien-Manh Hoang, Hieu Hoang Van
OBJECTIVE: Gastric cancer (GC) is one of the most common malignancies and ranks third in terms of cancer-related mortality. This study aims to identify the hub genes and potential mechanisms in GC using a bioinformatics approach. METHODS: Microarray data GSE54129, GSE79973, GSE55696 were extracted from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) was identified using Benjamini-Hochberg method in the limma package. GO and KEGG pathway enrichment analyses of the DEGs were conducted...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38536928/bond-length-dependence-of-attosecond-ionization-delays-in-o-2-arising-from-electron-correlation-to-a-shape-resonance
#3
JOURNAL ARTICLE
Daniel Hammerland, Thomas Berglitsch, Pengju Zhang, Tran Trung Luu, Kiyoshi Ueda, Robert R Lucchese, Hans Jakob Wörner
We experimentally and theoretically demonstrate that electron correlation can cause the bond-length sensitivity of a shape resonance to induce an unexpected vibrational state-dependent ionization delay in a nonresonant channel. This discovery was enabled by a high-resolution attosecond-interferometry experiment based on a 400-nm driving and dressing wavelength. The short-wavelength driver results in a 6.2-electron volt separation between harmonics, markedly reducing the spectral overlap in the measured interferogram...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38534953/perspectives-on-ease-of-use-and-value-of-a-self-monitoring-application-to-support-physical-activity-maintenance-among-individuals-living-with-and-beyond-cancer
#4
JOURNAL ARTICLE
Manuel Ester, Meghan H McDonough, Mannat Bansal, Julianna Dreger, Julia T Daun, Margaret L McNeely, Thompson Luu, S Nicole Culos-Reed
BACKGROUND: Physical activity (PA) can improve the physical and psychosocial health of individuals with cancer, yet PA levels remain low. Technology may address PA maintenance barriers in oncology, though the intervention effectiveness to date remains mixed. Qualitative research can reveal the nuances of using technology-based PA maintenance tools. The present study aimed to understand the perspectives of individuals with cancer on using an app to support PA maintenance. METHODS: Individuals were interviewed after using a self-monitoring app for 24 weeks, asking about their app use, ease of use, and perceived value for supporting PA...
March 19, 2024: Current Oncology
https://read.qxmd.com/read/38531976/more-than-double-the-fun-with-two-photon-excitation-microscopy
#5
REVIEW
Peter Luu, Scott E Fraser, Falk Schneider
For generations researchers have been observing the dynamic processes of life through the lens of a microscope. This has offered tremendous insights into biological phenomena that span multiple orders of time- and length-scales ranging from the pure magic of molecular reorganization at the membrane of immune cells, to cell migration and differentiation during development or wound healing. Standard fluorescence microscopy techniques offer glimpses at such processes in vitro, however, when applied in intact systems, they are challenged by reduced signal strengths and signal-to-noise ratios that result from deeper imaging...
March 26, 2024: Communications Biology
https://read.qxmd.com/read/38531874/profiling-the-colonic-mucosal-response-to-fecal-microbiota-transplantation-identifies-a-role-for-gbp5-in-colitis-in-humans-and-mice
#6
JOURNAL ARTICLE
Laurence D W Luu, Abhimanu Pandey, Sudarshan Paramsothy, Chinh Ngo, Natalia Castaño-Rodríguez, Cheng Liu, Michael A Kamm, Thomas J Borody, Si Ming Man, Nadeem O Kaakoush
Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic mucosal transcriptome prior to and following FMT or placebo to identify molecules regulated during disease remission. FMT alters the transcriptome above the effect of placebo (n = 75 vs 3 genes, q < 0.05), including modulation of structural, metabolic and inflammatory pathways. This response is attributed to responders with no consistency observed in non-responders...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38530112/low-carbohydrate-diet-score-and-risk-of-hepatocellular-carcinoma-findings-from-a-prospective-cohort-study
#7
JOURNAL ARTICLE
Yen Thi-Hai Pham, Aizhen Jin, Renwei Wang, Jaideep Behari, Woon-Puay Koh, Jian-Min Yuan, Hung N Luu
Limited data are reported on the association between low-carbohydrate diet (LCD) score, a comprehensive measure of dietary pattern according to sources of carbohydrate, fat and protein, and risk of hepatocellular carcinoma (HCC). We evaluated this score with HCC risk in the Singapore Chinese Health Study, a prospective cohort of 63,275 middle-aged and elderly Chinese living in Singapore and recruited during 1993-1998 period. LCD scores were derived from the semi-quantitative food frequency questionnaire at baseline...
March 26, 2024: Cancer Prevention Research
https://read.qxmd.com/read/38521815/high-biocompatible-fitc-conjugated-silica-nanoparticles-for-cell-labeling-in-both-in-vitro-and-in-vivo-models
#8
JOURNAL ARTICLE
Thi Thuy Nguyen, Hoang Nam Nguyen, Thi Ha Lien Nghiem, Xuan-Hai Do, Thanh Thuy To, Thi Xuan Phuong Do, Dieu Linh Do, Huong Giang Nguyen, Huy Manh Nguyen, Ngoc Dinh Nguyen, Manh Quynh Luu, Trong Nghia Nguyen, Thi Bich Ngoc Nguyen, Van Toan Nguyen, Van Thanh Pham, Uyen Thi Trang Than, Thi My Nhung Hoang
Fluorescence nanosilica-based cell tracker has been explored and applied in cell biological research. However, the aggregation of these nanoparticles at physiological pH is still the main limitation. In this research, we introduced a novel fluorescence nano-based cell tracker suitable for application in live cells. The silica-coated fluorescein isothiocyanate isomer (FITC-SiO2 ) nanoparticles (NPs) were modified with carboxymethylsilanetriol disodium salt (FITC-SiO2 -COOH), integrating the dianion form of FITC molecules...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38519750/exploring-the-phytochemical-diversity-and-antioxidant-potential-of-the-vietnamese-smilax-glabra-roxb-insights-from-uplc-qtof-ms-ms-and-zebrafish-model-studies
#9
JOURNAL ARTICLE
Vu Thanh Nguyen, Vo Thi Minh Thao, Le Luu Phuong Hanh, Thi Hoa Rol, Ngo Huynh Phuong Thao, Tong Xuan Nguyen, Pham Thanh Luu, Dinh Thi Thuy
Research on natural products is growing due to their potential health benefits and medicinal properties. Despite regional variations in phytochemical composition and bioactivity, Smilax glabra Roxb (SGB) has attracted the interest of researchers. Scientists are particularly interested in the Vietnamese SGB variant, which is influenced by biological and environmental factors. Despite geographical differences in phytochemical makeup and bioactivities, SGB remains a fascinating subject in traditional herbal medicine...
March 23, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38515405/post-stroke-care-pathways-and-spasticity-treatment-a-retrospective-study-in-alberta
#10
JOURNAL ARTICLE
Lalith Satkunam, Sean P Dukelow, Jaime Yu, Stephen McNeil, Huong Luu, Karen Jb Martins, Khanh Vu, Phuong Uyen Nguyen, Lawrence Richer, Tyler Williamson, Scott W Klarenbach
No abstract text is available yet for this article.
March 22, 2024: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/38515356/immune-cell-mediated-autoimmune-responses-in-severe-asthma
#11
REVIEW
Thi Bich Tra Cao, Quang Luu Quoc, Jae-Hyuk Jang, Hae-Sim Park
Severe asthma (SA) has heterogeneous inflammatory phenotypes characterized by persistent airway inflammation (eosinophilic and/or neutrophilic inflammation) and remodeling. Various immune cells (eosinophils, neutrophils, and macrophages) become more activated and release inflammatory mediators and extracellular traps, damaging the protective barrier of airway epithelial cells and further activating other immune and structural cells. These cells play a role in autoimmune responses in asthmatic airways, where the adaptive immune system generates autoantibodies, inducing immunoglobulin G-dependent airway inflammation...
April 2024: Yonsei Medical Journal
https://read.qxmd.com/read/38504318/adoption-of-c-reactive-protein-rapid-tests-for-the-management-of-acute-childhood-infections-in-hospitals-in-the-netherlands-and-england-a-comparative-health-systems-analysis
#12
JOURNAL ARTICLE
Juan Emmanuel Dewez, Ruud G Nijman, Elizabeth J A Fitchett, Edmond C Li, Queena F Luu, Rebecca Lynch, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Ria Philipsen, Stefanie Ettelt, Shunmay Yeung
BACKGROUND: The adoption of C-reactive protein point-of-care tests (CRP POCTs) in hospitals varies across Europe. We aimed to understand the factors that contribute to different levels of adoption of CRP POCTs for the management of acute childhood infections in two countries. METHODS: Comparative qualitative analysis of the implementation of CRP POCTs in the Netherlands and England. The study was informed by the non-adoption, abandonment, spread, scale-up, and sustainability (NASSS) framework...
March 19, 2024: BMC Health Services Research
https://read.qxmd.com/read/38501574/undescribed-lignanamide-and-flavone-c-glucoside-isolated-from-the-aerial-parts-of-piper-samentosum-with-no-production-inhibitory-activity-in-lps-activated-raw-264-7-cells
#13
JOURNAL ARTICLE
Le Thi Huyen, Luu Nhu Thao, Nhu Thi Hang Nga, Quach Thi Khanh Ly, Nguyen Thi Son, Bui Huu Huu Tai, Sy Thinh Ngo, Phan Van Kiem
In this study, two undescribed compounds (1 and 2), together with eight known compounds (3-10) were isolated from the aerial parts of Piper samentosum by various chromatography methods. Their chemical structures were determined to be 7'''-oxolyciumamide N (1), vitexin 2''-O-β-D-(6'''-feruloyl)-glucopyranoside (2), 1,2-dihydro-6,8-dimethoxy-7-hydroxy-1-(3,4-dihydroxyphenyl)-N1,N2-bis-[2-(-hydroxyphenyl)ethyl]-2,3-napthalene dicarboamide (3), vitexin 6''-O-β-D-glucopyranoside (4), vitexin 2''-O-α-L-rhamnopyranoside (5), methyl 2-hydroxybenzoate-2-O-β-D-apiofuranosyl-(1→2)-O-β-D-glucopyranoside (6), ficuside G (7), methyl 2-O-β-D-glucopyranosylbenzoate (8), methyl 2,5-dihydroxybenzoate-5-O-β-D-glucopyranoside (9), and 3,7-dimethyloct-1-ene-3,6,7-triol 6-O-β-D-glucopyranoside (10) by spectroscopic data analysis including HR-ESI-MS, 1D-, and 2D-NMR spectra...
March 19, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38494955/antibody-epitope-conjugates-deliver-immunogenic-t-cell-epitopes-more-efficiently-when-close-to-cell-surfaces
#14
JOURNAL ARTICLE
W van der Wulp, W Luu, M E Ressing, J Schuurman, S I van Kasteren, L Guelen, R C Hoeben, B Bleijlevens, M H M Heemskerk
Antibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. Multiple strategies for viral epitope delivery have been shown to be effective. So far, most of these have relied on a free C-terminus of the immunogenic epitope for extracellular delivery. Here, we demonstrate that antibody-epitope conjugates (AECs) with genetically fused epitopes to the N-terminus of the antibody can also sensitize tumors for attack by virus-specific CD8+ T cells...
2024: MAbs
https://read.qxmd.com/read/38490923/contemporary-risk-of-biochemical-recurrence-after-radical-prostatectomy-in-the-active-surveillance-era
#15
JOURNAL ARTICLE
Sanjay Das, Michael Luu, Martha Terris, Zachary Klaassen, Christopher J Kane, Christopher Amling, Matthew Cooperberg, Lourdes Guerrios Rivera, William Aronson, Stephen J Freedland, Timothy J Daskivich
OBJECTIVES: To assess whether contemporary risks of biochemical recurrence (BCR) after radical prostatectomy (RP) in the AS era differ from historical estimates due to changes in tumor risk case mix and improvements in risk stratification. MATERIALS AND METHODS: We sampled 6,682 men who underwent RP for clinically localized disease between 2000 and 2017 from the VA SEARCH database. Kaplan Meier analysis was used to calculate incidence of BCR before and after 2010 overall and within tumor risk subgroups...
March 14, 2024: Urologic Oncology
https://read.qxmd.com/read/38489310/anxiety-and-its-risk-factors-among-non-japanese-residents-living-in-japan-undergoing-covid-19-situation-a-cross-sectional-survey
#16
JOURNAL ARTICLE
Mai Ngoc Luu, Atsuko Imoto, Yoshimi Matsuo, Nguyen Tien Huy, Ahmad Qarawi, Shamael Thabit Mohammed Alhady, Le Van Truong, Ryuji Yoshino, Nguyen Tran Minh Duc, Kozue Tabei, Yixiao Lu, Manmeet Kaur Singh, Mai Phuong Truong, Shyam Prakash Dumre, Ian Christopher Naungayan Rocha, I-Chun Hung, Akane Fudo, Miho Sato, Sajog Kansakar, Akiko Tsukamoto, Aiko Komatsu, Guoxi Cai, Kazuhiko Moji, Thanawat Khongyot, Saruveish Mogan, Souksavath Soukdavone, Endah Dwi Hartuti, Kounnavong Thidatheb, Shiho Honda, Hyunjae Woo, Nitu Lama, Vy Thi Nhat Huynh, Huynh Le Anh Khoa, Kirellos Said Abbas, Fatma A Monib, Hoda Aly Mohamed Omran, Chiristine Samuel Rezq, Mostafa Shehata Qatora, Sze Jia Ng, Graca Jaqueline Vanessa Morena, Adriana Viola Miranda, Minh-Trang Ngo Huynh, Junko Ota, Kim Minjung, Jaemin An, Latdavanh Vorlasane, Kesshinee Gunasegaran, Fazureen Zulkefli, Belen de Jesús Lima Girón, Punita Gauchan Bhattachan, Renu Bhandari Dumre, Kishor Pandey, Sarina Yamashita, Aden Kay Celis Seposo, Jayson Zabala, Adrián Riva-Moscoso, Joyce Nicole Pineda Ordóñez, Suriyon Uitrakul, Fortunato S Principe-Meneses, Kadek Agus Surya Dila
INTRODUCTION: In the context of collective efforts taken in Japan to control the spread of COVID-19, the state of emergency and social distancing have caused a negative impact on the mental health of all residents, including foreign communities in Japan. This study aimed to evaluate the level of anxiety and its associated factors among non-Japanese residents residing in Japan during the COVID-19 pandemic. METHODS: A web-based survey in 13 languages was conducted among non-Japanese residents living in Japan during the COVID-19 situation...
2024: PloS One
https://read.qxmd.com/read/38479254/fine-tuning-detr-toward-holistic-process-in-plastic-waste-sorting-system
#17
JOURNAL ARTICLE
Tri Thanh Nguyen, Thanh Tung Luu, Phuoc Thanh An Tong
Every year human discharges about 350 million tons of plastic waste into the environment and can be projected to triple in 2060 without any attempts to change situation. From 1970 to 2019, an estimation of 130 million tons of plastic waste was accumulated into the rivers, lakes and sea, while only 27 % is recycled and utilized. Moreover, waste treatment plants in most places around the world are using out-of-date technology, may pose a threat to the health of the workers. Therefore, it is essential to modernize these systems for protecting human health...
March 12, 2024: Waste Management
https://read.qxmd.com/read/38478660/implementation-of-a-dermatology-skin-of-color-educational-module-for-medical-students
#18
JOURNAL ARTICLE
Joseph Han, Dante Dahabreh, Aneesh Agarwal, Yen Luu, Samir Kamat, Alexandra Golant, Jonathan Ungar, Nicholas Gulati
Research in dermatology education highlights the lack of skin of color (SOC) instruction for medical students, leading to concerning healthcare outcomes. Because of the already limited opportunity for students to have dedicated teaching in pathophysiology, management, and treatment of dermatologic diseases in medical school, we developed an educational module that addresses these gaps. We created a one-hour virtual lecture for medical students focused on common skin diseases tested on the United States Medical Licensing Examination with visual images across all skin types...
December 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38452999/wearable-sensors-to-monitor-physical-activity-in-heart-failure-clinical-trials-state-of-the-art-review
#19
REVIEW
Ruben Buendia, Martin Karpefors, Folke Folkvaljon, Robert Hunter, Henrik Sillen, Long Luu, Kieran Docherty, Martin R Cowie
BACKGROUND: Estimation of the effect that a drug or other intervention has on patient symptoms and functions is crucial in heart failure trials. Traditional symptoms and functions clinical outcome assessments have important limitations. Actigraphy may help to overcome these limitations due to its objective nature and the potential for continuous recording of data. However, actigraphy is not currently accepted as clinically relevant by key stakeholders. METHODS AND RESULTS: In this This State-of-the-Art paper, the key aspects to consider when implementing actigraphy in heart failure trials are discussed...
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38448820/characterisation-and-reproducibility-of-the-humanmethylationepic-v2-0-beadchip-for-dna-methylation-profiling
#20
JOURNAL ARTICLE
Timothy J Peters, Braydon Meyer, Lauren Ryan, Joanna Achinger-Kawecka, Jenny Song, Elyssa M Campbell, Wenjia Qu, Shalima Nair, Phuc Loi-Luu, Phillip Stricker, Elgene Lim, Clare Stirzaker, Susan J Clark, Ruth Pidsley
BACKGROUND: The Illumina family of Infinium Methylation BeadChip microarrays has been widely used over the last 15 years for genome-wide DNA methylation profiling, including large-scale and population-based studies, due to their ease of use and cost effectiveness. Succeeding the popular HumanMethylationEPIC BeadChip (EPICv1), the recently released Infinium MethylationEPIC v2.0 BeadChip (EPICv2) claims to extend genomic coverage to more than 935,000 CpG sites. Here, we comprehensively characterise the reproducibility, reliability and annotation of the EPICv2 array, based on bioinformatic analysis of both manifest data and new EPICv2 data from diverse biological samples...
March 6, 2024: BMC Genomics
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