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https://www.readbyqxmd.com/read/27911755/transformation-of-vestibular-signals-for-the-control-of-standing-in-humans
#1
Patrick A Forbes, Billy L Luu, H F Machiel Van der Loos, Elizabeth A Croft, J Timothy Inglis, Jean-Sébastien Blouin
: During standing balance, vestibular signals encode head movement and are transformed into coordinates that are relevant to maintaining upright posture of the whole body. This transformation must account for head-on-body orientation as well as the muscle actions generating the postural response. Here, we investigate whether this transformation is dependent upon a muscle's ability to stabilize the body along the direction of a vestibular disturbance. Subjects were braced on top of a robotic balance system that simulated the mechanics of standing while being exposed to an electrical vestibular stimulus that evoked a craniocentric vestibular error of head roll...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27905484/independent-control-of-natural-killer-cell-responsiveness-and-homeostasis-at-steady-state-by-cd11c-dendritic-cells
#2
Thuy Thanh Luu, Sridharan Ganesan, Arnika Kathleen Wagner, Dhifaf Sarhan, Stephan Meinke, Natalio Garbi, Günter Hämmerling, Evren Alici, Klas Kärre, Benedict J Chambers, Petter Höglund, Nadir Kadri
During infection and inflammation, dendritic cells (DC) provide priming signals for natural killer (NK) cells via mechanisms distinct from their antigen processing and presentation functions. The influence of DC on resting NK cells, i.e. at steady-state, is less well studied. We here demonstrate that as early as 1 day after DC depletion, NK cells in naïve mice downregulated the NKG2D receptor and showed decreased constitutive phosphorylation of AKT and mTOR. Subsequently, apoptotic NK cells appeared in the spleen concomitant with reduced NK cell numbers...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895862/cutaneous-angiosarcoma-metastatic-to-small-bowel-with-nodal-involvement
#3
Vidya A Fleetwood, Jamie C Harris, Minh B Luu
A 77-year-old male with a history of metastatic scalp angiosarcoma presented with intractable gastrointestinal bleeding from a jejunal mass detected on capsule endoscopy. He underwent laparoscopic-assisted resection of the mass. Intraoperatively, an isolated small bowel mass with bulky lymphadenopathy was seen and resected en bloc. Pathology showed a 6.8cm high-grade metastatic angiosarcoma with nodal involvement and negative margins. Angiosarcoma is a sarcoma with a grim prognosis. The incidence is 2% of all soft tissue sarcomas; cutaneous lesions comprise 27% of manifestations and usually appear on head and neck...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27886900/differential-diagnosis-of-atopic-dermatitis
#4
REVIEW
Meagan Barrett, Minnelly Luu
Atopic dermatitis (AD) is a common inflammatory condition of the skin that is usually seen in childhood, but can onset or persist into adulthood. The characteristic distribution and morphology based on age, chronic relapsing course, and pruritus comprise the clinical criteria used in the diagnosis of AD. However, the numerous morphologies ranging from acute, weeping erythematous papules to chronic lichenified plaques, can be simulated by multiple other conditions, including inflammatory, infectious, neoplastic, and photo-dermatoses...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27878546/investigation-of-antibiotics-in-health-care-wastewater-in-ho-chi-minh-city-vietnam
#5
Thi-Dieu-Hien Vo, Xuan-Thanh Bui, Ngoc-Dan-Thanh Cao, Vinh-Phuc Luu, Thanh-Tin Nguyen, Bao-Trong Dang, Minh-Quan Thai, Dinh-Duc Nguyen, Thanh-Son Nguyen, Quoc-Tuc Dinh, Thanh-Son Dao
Hospital wastewater contains huge amounts of hazardous pollutants which are being discharged daily to environment with or without treatment. Antibiotics were among the important group of pharmaceuticals considered as a potential source of health risk for human and other living creatures. Although the investigations about the existence of antibiotics in hospital wastewater have gained concern for researchers in many countries, there is only one research conducted in Hanoi-Vietnam. Hence, in this study, investigations have been done to fulfill the requirement of real situation in Vietnam by accomplishing survey for 39 health care facilities in Ho Chi Minh City...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27837222/diarrhea-risks-by-exposure-to-livestock-waste-in-vietnam-using-quantitative-microbial-risk-assessment
#6
Thu Le-Thi, Phuc Pham-Duc, Christian Zurbrügg, Toan Luu-Quoc, Huong Nguyen-Mai, Tu Vu-Van, Hung Nguyen-Viet
OBJECTIVES: The aim of this paper was to assess the diarrhea risks caused by various pathogens among those exposed to biogas wastewater through different activities. METHODS: Application of quantitative microbial risk assessment (QMRA) of biogas wastewater was conducted in Hanam Province, Vietnam. A total of 451 representatives from households that use biogas were interviewed about their practices of handling biogas plant and reuse of biogas effluent for irrigation...
November 11, 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/27826941/circumportal-pancreas-a-must-know-pancreatic-anomaly-for-the-pancreatic-surgeon
#7
Andreas Minh Luu, C Braumann, T Herzog, M Janot, W Uhl, A M Chromik
PURPOSE: Circumportal pancreas is a rare congenital pancreatic anomaly with encasement of the portal vein and/or the superior mesenteric vein by pancreatic tissue. It is often overlooked on cross-sectional imaging studies and can be encountered during pancreatic surgery. Pancreatic head resection with circumportal pancreas is technically difficult and bears an increased risk of postoperative pancreatic fistula. MATERIALS AND METHODS: A retrospective chart review of our data base for all patients who had undergone pancreatic head resection between 2004 and 2015 was performed...
November 8, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27805503/microvascular-invasion-in-hepatocellular-carcinoma-and-liver-transplant
#8
Neha Jakhete, Behnam Saberi, Naudia L Jonassaint, Arif M Cosar, Harry Luu, Amy Kim, Robert A Anders, Benjamin Philosophe, Andrew M Cameron, Ahmet Gurakar
OBJECTIVES: Curative therapy for hepatocellular carcinoma is liver transplant. To date, the Milan Criteria remain the best pretransplant clinical surrogate for tumor behavior and overall prognosis. Microvascular invasion portends a poor prognosis; however, it is often undetectable before transplant. Furthermore, its pretransplant indicators are not well established. In this study, we investigated the presurgical and pathologic predictors of microvascular invasion in patients with hepatocellular carcinoma...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27799825/utilization-of-services-provided-by-village-based-ethnic-minority-midwives-in-mountainous-villages-of-vietnam
#9
Duong Thi Thuy Doan, Ha Thi Thu Bui, Thi Minh Le, Duc Minh Duong, Hong Thi Luu, Tuan Anh Dinh, Tolib Mirzoev
INTRODUCTION: Since 2011, the Vietnam's Ministry of Health implemented the ethnic minority midwives (EMMs) scheme in order to increase the utilization of maternal health services by women from ethnic minorities and those living in hard-to-reach mountainous areas. This paper analyzes the utilization of antenatal, delivery, and postpartum care provided by EMMs and reports the key determinants of utilization of EMM services as perceived by service users. METHODS: A structured questionnaire was administered in 2015 to all mothers (n=320) who gave birth to a live-born during a 1-year period in 31 villages which had EMM in two provinces, Dien Bien and Kon Tum...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27794223/semi-preparative-hplc-separation-followed-by-hplc-uv-and-tandem-mass-spectrometric-analysis-of-phorbol-esters-in-jatropha-seed
#10
Santi Kongmany, Truong Thi Hoa, Le Thi Ngoc Hanh, Kiyoshi Imamura, Yasuaki Maeda, Luu Van Boi
Phorbol esters (PEs) are well known as the main toxic compounds in Jatropha curcas Linnaeus (JCL), the seed oil of which has been considered as a major feedstock for the production of biodiesel. In the present study, we investigated a series of PEs extracted from JCL seed kernels with methanol (MeOH), and identified more than seven components contained in the PEs. The isolation of main five components of a series of PEs was revised using a semi-preparative reversed phase HPLC analysis of ODS-3 column. The five peaks of components were successfully isolated, and peaks of J2, J3, J5, and J7 were assigned to be Jatropha factors C1, C2, C3, and C4/5, but J6 was a mixture of Jatropha factor C6 and its isomer based on the data of UV and LC-MS/MS, and J2 was identified using (1)H NMR analysis...
October 14, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27793907/selective-toxicity-of-a-highly-potent-camptothecin-analogue-a-pilot-study-with-glioblastoma-multiforme-cells
#11
Garret Yount, Liliana Soroceanu, Hui-Juan Wang, Eric Singer, Romi Yount, Tran Luu, Li-Xi Yang
BACKGROUND/AIM: We developed a novel camptothecin analogue, CPT417, that yields reduced toxicity compared to other analogues used in chemotherapeutic regimens. In this pilot study, we assessed the activity of CPT417 against glioblastoma multiforme (GBM) cells and glioma stem cells. MATERIALS AND METHODS: The human U251 GBM cell line and normal human astrocytes were cultured in parallel for clonogenic survival analysis following exposure to increasing concentrations of CPT417...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27775509/automatic-identification-of-pathology-distorted-retinal-layer-boundaries-using-sd-oct-imaging
#12
Md Akter Hussain, Alauddin Bhuiyan, Andrew Turpin, Chi D Luu, R Theodore Smith, Robyn H Guymer, Ramamohanarao Kotagiri
OBJECTIVE: We propose an effective, automatic method for identification of four retinal layer boundaries from the Spectral Domain Optical Coherence Tomography (SD-OCT) images in the presence and absence of pathologies and morphological changes due to disease. METHODS: The approach first finds an approximate location of three reference layers, and then uses these to bound the search space for the actual layers, which is achieved by modeling the problem as a graph and applying Dijkstra's shortest path algorithm...
October 19, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27765800/sex-specific-associations-between-one-carbon-metabolism-indices-and-posttranslational-histone-modifications-in-arsenic-exposed-bangladeshi-adults
#13
Caitlin G Howe, Xinhua Liu, Megan N Hall, Vesna Ilievski, Marie A Caudill, Olga Malysheva, Angela M Lomax-Luu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad N Uddin, Tariqul Islam, Joseph H Graziano, Max Costa, Mary V Gamble
BACKGROUND: Posttranslational histone modifications (PTHMs) are altered by arsenic, an environmental carcinogen. PTHMs are also influenced by nutritional methyl donors involved in one-carbon metabolism (OCM), which may protect against epigenetic dysregulation. METHODS: We measured global levels of three PTHMs, which are dysregulated in cancers (H3K36me2, H3K36me3, H3K79me2), in peripheral blood mononuclear cells (PBMCs) from 324 participants enrolled in the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults...
October 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27765482/bacteremia-in-nonneutropenic-pediatric-oncology-patients-with-central-venous-catheters-in-the-ed
#14
Risha L Moskalewicz, Leidy L Isenalumhe, Cindy Luu, Choo Phei Wee, Alan L Nager
OBJECTIVE: To examine clinical characteristics associated with bacteremia in febrile nonneutropenic pediatric oncology patients with central venous catheters (CVCs) in the emergency department (ED). BACKGROUND: Fever is the primary reason pediatric oncology patients present to the ED. The literature states that 0.9% to 39% of febrile nonneutropenic oncology patients are bacteremic, yet few studies have investigated infectious risk factors in this population. METHODS: This was a retrospective cohort study in a pediatric ED, reviewing medical records from 2002 to 2014...
September 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27762353/multi-petahertz-electronic-metrology
#15
M Garg, M Zhan, T T Luu, H Lakhotia, T Klostermann, A Guggenmos, E Goulielmakis
The frequency of electric currents associated with charge carriers moving in the electronic bands of solids determines the speed limit of electronics and thereby that of information and signal processing. The use of light fields to drive electrons promises access to vastly higher frequencies than conventionally used, as electric currents can be induced and manipulated on timescales faster than that of the quantum dephasing of charge carriers in solids. This forms the basis of terahertz (10(12) hertz) electronics in artificial superlattices, and has enabled light-based switches and sampling of currents extending in frequency up to a few hundred terahertz...
October 19, 2016: Nature
https://www.readbyqxmd.com/read/27761754/review-of-osteosarcoma-and-current-management
#16
REVIEW
Ryan A Durfee, Maryam Mohammed, Hue H Luu
Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical management of this tumor. Finally, the review will discuss some of the novel approaches to treating this disease...
December 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27758929/determinants-of-developmental-outcomes-in-a-very-preterm-canadian-cohort
#17
Anne Synnes, Thuy Mai Luu, Diane Moddemann, Paige Church, David Lee, Michael Vincer, Marilyn Ballantyne, Annette Majnemer, Dianne Creighton, Junmin Yang, Reginald Sauve, Saroj Saigal, Prakesh Shah, Shoo K Lee
OBJECTIVES: Identify determinants of neurodevelopmental outcome in preterm children. METHODS: Prospective national cohort study of children born between 2009 and 2011 at <29 weeks gestational age, admitted to one of 28 Canadian neonatal intensive care units and assessed at a Canadian Neonatal Follow-up Network site at 21 months corrected age for cerebral palsy (CP), visual, hearing and developmental status using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III)...
October 6, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27756230/circulating-granulysin-levels-in-healthcare-workers-and-latent-tuberculosis-infection-estimated-using-interferon-gamma-release-assays
#18
Pham Huu Thuong, Do Bang Tam, Shinsaku Sakurada, Nguyen Thi Le Hang, Minako Hijikata, Le Thi Hong, Phan Thi Minh Ngoc, Pham Thu Anh, Vu Cao Cuong, Ikumi Matsushita, Luu Thi Lien, Naoto Keicho
BACKGROUND: Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tuberculosis (TB) infection. METHODS: Latency of TB infection among Vietnamese healthcare workers was estimated using interferon-gamma release assays (IGRA), and serum GNLY concentrations were measured using enzyme-linked immunosorbent assays. The levels of GNLY expression in whole blood and the presence of GNLY alleles with the exon-4 polymorphism rs11127 were also determined using PCR-based methods...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27756079/assessment-of-retinotopic-rod-photoreceptor-function-using-a-dark-adapted-chromatic-perimeter-in-intermediate-age-related-macular-degeneration
#19
Rogan G Fraser, Rose Tan, Lauren N Ayton, Emily Caruso, Robyn H Guymer, Chi D Luu
Purpose: We determine the feasibility of using a dark-adapted chromatic (DAC) perimeter to obtain dark-adapted static and dynamic rod function at multiple retinal locations, and compare these functional parameters between subjects with intermediate age-related macular degeneration (AMD) and normal controls. Methods: Perimetric dark-adapted retinal sensitivities for the 505 and 620 nm stimuli across 7 retinal locations within the central 12° were repeatedly measured after exposing to a single photobleach in 22 intermediate AMD subjects and 8 controls...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27753874/yia-01-01-adverse-neonatal-health-correlates-with-long-term-cardiac-functional-and-structural-remodeling-in-young-adults-born-preterm
#20
Muhammad Oneeb Rehman Mian, Julie Demeulemeester, Jean-Luc Bigras, Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Rong Wu, Anik Cloutier, Thuy Mai Luu, Anne-Monique Nuyt
OBJECTIVE: Studies support a direct causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass, and impaired systolic and diastolic function were observed in young adults born preterm. Deleterious neonatal conditions, as in preterm birth, could significantly impact on myocardial tissue. We investigated how left ventricle (LV) echocardiographic parameters in young adults born preterm correlated with neonatal health parameters and interventions data...
September 2016: Journal of Hypertension
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