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https://www.readbyqxmd.com/read/29455042/trapping-of-1-2-cyclohexadiene-a-dft-mechanistic-study-on-the-reaction-of-1-2-cyclohexadiene-with-olefins-and-nitrones
#1
Emmanuel Amoah Boafo, Kwabena Darko, Bright Aryeh Afriyie, Richard Tia, Evans Adei
The mechanistic aspects of cycloaddition reactions of 1,2-cyclohexadiene with olefins and nitrones have been investigated with DFT calculations. The results show that the cycloaddition reactions of 1,2-cyclohexadiene with olefins do not go through a concerted pathway (one-step mechanism) but rather a stepwise one involving the formation of a biradical intermediate which then closes to form final cycloadduct. Electron-withdrawing substituents on the 1,2-cyclohexadiene decrease the activation barrier of the biradical-forming step but increase the barrier of the product-forming step and product stability, while electron-donating substituents on the 1,2-cyclohexadiene increase the barriers for both the biradical-forming step and the product-forming step but decrease the product stability...
February 13, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29452141/a-rich-source-of-potential-bioactive-compounds-with-anticancer-activities-by-catharanthus-roseus-cambium-meristematic-stem-cell-cultures
#2
So Hyun Moon, Muthuraman Pandurangan, Doo Hwan Kim, Jelli Venkatesh, Rahul V Patel, Bhupendra M Mistry
ETHNOPHARMACOLOGICAL IMPORTANCE: Catharanthus roseus (L.) G. Don. is an important medicinal plant with rich sources of remarkable health benefits consisting more than 100 alkaloids and significant amounts of bioactive compounds, which have been widely used as a folk medicine for treatment of several pathologies. THE AIM OF THE STUDY: In the present study, we isolated and cultured innately undifferentiated cambium meristematic cells (CMCs), which were observed stable cell growth, enhancement of bioactive compounds from C...
February 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29446950/isosteric-substitution-of-4h-1-2-4-triazole-by-1h-1-2-3-triazole-in-isophthalic-derivative-enabled-hydrogel-formation-for-controlled-drug-delivery
#3
Marleen Häring, Julio Rodríguez-López, Santiago Grijalvo, Markus Tautz, Ramon Eritja, Victor S Martin, David Díaz Díaz
In this work we demonstrated that the simple substitution of the 1,2,4-triazole moiety in 5-(4H-1,2,4-triazol-4-yl)isophthalic acid (5-TIA) by the 1H-1,2,3-triazol-5-yl unit enables the preparation of a hydrogelator (click-TIA). In sharp contrast to 5-TIA, its isostere click-TIA undergoes self-assembly in water upon sonication, leading to the formation of stable supramolecular viscoelastic hydrogels with a critical gelation concentration of 6 g/L. Hydrogels made of click-TIA as well as hybrid hydrogels made of the mixture click-TIA + 5-TIA (molar ratio 1:0...
February 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29440471/clinical-and-demographic-characteristics-associated-with-suboptimal-primary-stroke-and-transient-ischemic-attack-prevention-retrospective-analysis
#4
Grace M Turner, Melanie Calvert, Max G Feltham, Ronan Ryan, Samuel Finnikin, Tom Marshall
BACKGROUND AND PURPOSE: Primary prevention of stroke and transient ischemic attack (TIA) is important to reduce the burden of these conditions; however, prescribing of prevention drugs is suboptimal. We aimed to identify individual clinical and demographic characteristics associated with potential missed opportunities for prevention therapy with lipid-lowering, anticoagulant, or antihypertensive drugs before stroke/TIA. METHODS: We analyzed anonymized electronic primary care records from a UK primary care database that covers 561 family practices...
February 13, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29438515/diabetes-and-long-term-outcomes-of-ischaemic-stroke-findings-from-get-with-the-guidelines-stroke
#5
Justin B Echouffo-Tcheugui, Haolin Xu, Roland A Matsouaka, Ying Xian, Lee H Schwamm, Eric E Smith, Deepak L Bhatt, Adrian F Hernandez, Paul A Heidenreich, Gregg C Fonarow
Aims: There is a paucity of data on the influence of diabetes on long-term outcomes after ischaemic stroke (IS). We assessed whether outcomes after IS differ between patients with and without diabetes. Methods and results: Patients aged ≥65 years (n = 409 060) in Get With The Guidelines-Stroke (nationwide registry of stroke patients from 1690 sites in the USA) were followed for 3 years post-discharge. The outcomes of interest were mortality, cardiovascular and non-cardiovascular hospitalizations, heart failure (HF), and recurrence of IS/transient ischaemic attack (TIA)...
February 9, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29431171/the-upgoing-thumb-sign-an-interobserver-intraobserver-reliability-study
#6
Shahram Abootalebi, Mahmoud Reza Azarpazhooh, Luciano Sposato, Vladimir Hachinski
Background: The upgoing thumb sign as a subtle clinical finding of upper motor neuron involvement has been frequently reported in patients with TIAs and minor strokes. This study was designed to show the method of examination and interpretation and the interobserver/intraobserver reliability. Methods: The thumb sign was elicited in TIA/minor strokes or stroke mimics. After obtaining the participant's permission, the examinations were recorded. Two independent neurologists reviewed all patients for the possibility of an upgoing thumb sign...
December 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29428326/a-modified-definition-for-obstructive-sleep-apnea-in-home-sleep-apnea-testing-after-stroke-or-transient-ischemic-attack
#7
Namita Patel, Afsaneh Raissi, Sara Elias, Maneesha Kamra, Tetyana Kendzerska, Brian J Murray, Mark I Boulos
BACKGROUND: Home sleep apnea testing (HSAT) underestimates obstructive sleep apnea (OSA) severity. Overnight oxygen desaturation has been shown to be a strong predictor of incident stroke, and may be helpful in determining which patients with lower apnea-hypopnea indices (AHIs) should be offered treatment. OBJECTIVES: To examine whether a modified definition for OSA that uses oxygen desaturation (i.e., AHI 5-14.9 per hour and lowest O2 desaturation ≤88%), as compared to an AHI ≥ 15 per hour, would impact: (1) changes in Epworth Sleepiness Scale scores post-continuous positive airway pressure (CPAP) initiation; (2) CPAP compliance rates; and (3) the accuracy of automated versus manual scoring of HSAT...
February 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29428128/role-of-forkhead-box-o-foxo-transcription-factor-in-aging-and-diseases
#8
REVIEW
Neelam Tia, Alok Kumar Singh, Poorti Pandey, Chandra Shekhar Azad, Pritee Chaudhary, Indrajeet Singh Gambhir
Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in their structure, function and regulation. To maintain optimum body function, the organisms have developed complex mechanisms for homeostasis. Importantly, it is well known that when these mechanisms dysregulate it results in the development of age-related disease. FOXO proteins are involved in a diverse cellular function and also have clinical significance including cell cycle arrest, cell differentiation, tumour suppression, DNA repair, longevity, diabetic complications, immunity, wound healing, regulation of metabolism and thus treatment of several types of diseases...
March 30, 2018: Gene
https://www.readbyqxmd.com/read/29423569/time-costs-for-genetic-counseling-in-preconception-carrier-screening-with-genome-sequencing
#9
Frances L Lynch, Patricia Himes, Marian J Gilmore, Elissa M Morris, Jennifer L Schneider, Tia L Kauffman, Elizabeth Shuster, Jacob A Reiss, John F Dickerson, Michael C Leo, James V Davis, Carmit K McMullen, Benjamin S Wilfond, Katrina A B Goddard
Advances in technology and the promise of personalized health care are driving greater use of genome sequencing (GS) for a variety of clinical scenarios. As health systems consider adopting GS, they need to understand the impact of GS on the organization and cost of care. While research has documented a dramatic decrease in the cost of sequencing and interpreting GS, few studies have examined how GS impacts genetic counseling workloads. This study examined the time needed to provide genetic counseling for GS in the context of preconception carrier screening...
February 8, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29422483/the-effects-of-isopropyl-methylphosphono-fluoridate-impf-poisoning-on-tumor-growth-and-angiogenesis-in-balb-c-mice
#10
Robert Zdanowski, Monika Leśniak, Urszula Karczmarczyk, Marek Saracyn, Marek Bilski, Anna Kiepura, Jacek Z Kubiak, Sławomir Lewicki
BACKGROUND Acetylcholinesterase (AChE) and cholinergic receptors have an important role in the immune system and angiogenesis. This work evaluated the effects of isopropyl methylphosphonofluoridate (IMPF), an irreversible inhibitor of AChE, on tumor growth and selected parameters associated with tumor angiogenesis. MATERIAL AND METHODS Experiments were performed on male BALB/c mice exposed to IMPF (study group) or saline buffer (control group) and inoculated with L-1 sarcoma; the number of new blood vessels (TIA test) and the level of αvβ3 integrin (131I-MAb-antiβ3 assay) were analyzed at seven, 14, or 21 days after implantation of the tumor cells...
February 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29422265/quality-of-life-after-percutaneous-closure-of-patent-foramen-ovale-in-patients-after-cryptogenic-stroke-compared-to-a-normative-sample
#11
Naqibullah Mirzada, Per Ladenvall, Per-Olof Hansson, Peter Eriksson, Charles Taft, Mikael Dellborg
AIMS: Despite the widespread use of percutaneous closure of patent foramen ovale (PFO) in patients after a cryptogenic stroke, little is known about its impact on health-related quality of life (HRQoL). The aim of this study was to assess HRQoL in these patients compared to PFO patients not considered candidates for percutaneous closure, and to a normal population. METHODS AND RESULTS: A total of 402 patients with cryptogenic stroke or transient ischaemic attack (TIA) who had been referred to our center for PFO closure were invited to a long-term clinical follow-up (mean follow-up 5...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29419706/rehabilitation-reduced-readmission-and-mortality-risks-in-patients-with-stroke-or-transient-ischemic-attack-a-population-based-study
#12
Ku-Chou Chang, Jen-Wen Hung, Hsuei-Chen Lee, Chu-Ling Yen, Ching-Yi Wu, Chung-Lin Yang, Yu-Ching Huang, Pei-Li Lin, Hui-Hsuan Wang
BACKGROUND: It remains unclear whether rehabilitation has an impact on reducing the long-term risk of mortality or readmission following stroke or transient ischemic attack (TIA). OBJECTIVES: To investigate the association between the dosage and continuation of rehabilitation and the risk of outcome events (OEs) after stroke or TIA. RESEARCH DESIGN: A retrospective cohort study using Taiwan's National Health Insurance database. SUBJECTS: In total, 4594 patients admitted with first-ever acute stroke or TIA were followed-up for 32 months...
February 6, 2018: Medical Care
https://www.readbyqxmd.com/read/29416879/establishing-research-priorities-relating-to-the-long-term-impact-of-tia-and-minor-stroke-through-stakeholder-centred-consensus
#13
Grace M Turner, Ruth Backman, Christel McMullan, Jonathan Mathers, Tom Marshall, Melanie Calvert
Plain English summary: What is the problem and why is this important? Mini-strokes are similar to full strokes, but symptoms last less than 24 h. Many people (up to 70%) have long-term problems after a mini-stroke, such as anxiety; depression; problems with brain functioning (like memory loss); and fatigue (feeling tired). However, the current healthcare pathway only focuses on preventing another stroke and care for other long-term problems is not routinely given. Without proper treatment, people with long-term problems after a mini-stroke could have worse quality of life and may find it difficult to return to work and their social activities...
2018: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29415863/-purple-urine-bag-syndrome-a-case-report
#14
Monlet Cy Guei, Kouamé Hubert Yao, Delphine Amelie Lagou, Pessa Nawo Albert Coulibaly, Amidou Sawadogo, Mohamed Ibrahim Alex Moudachirou, Weu Melanie Tia, Serge Didier Konan, Sery Diopoh, Ibrahim Cherif, Kan Clément Ackoundou-N'Guessan, Dazé Appolinaire Gnionsahe
Purple urine-bag syndrome is a rare condition that occurs in patients with indwelling urinary catheters carried over a long period and frequently associated with a urinary tract infection. It is characterized by the appearance of a violet coloration of the probe and/or the urine collection bag. We report the first case in West Africa that occurred in a 47-year-old woman in uremic encephalopathy and carrier of a urinary catheter, which presented a violet color of the tubing and urine-bag associated with a urinary tract infection...
February 4, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29414927/diagnostic-value-of-t1-slope-in-degenerative-cervical-spondylotic-myelopathy
#15
Jin Sun, Hong-Wei Zhao, Jun-Jie Wang, Liang Xun, Na-Xin Fu, Hui Huang
BACKGROUND To explore the diagnostic value of sagittal measurement of thoracic inlet parameters for degenerative cervical spondylotic myelopathy (DCSM). MATERIAL AND METHODS Sixty patients with DCSM (study group) and the same number of normal subjects (control group) were initially enrolled in the study. All data from X-ray in the standing position and computed tomography (CT) in the supine position were collected and carefully analyzed. Cervical sagittal parameters, including C2-C7 angle, C2-C7 sagittal vertical axis (C2-C7 SVA), T1 slope, thoracic inlet angle (TIA), and neck tilt (NT), were measured at the lateral radiographs by using standard X-rays and CT...
February 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29408529/endovascular-recanalization-for-chronic-symptomatic-intracranial-vertebral-artery-total-occlusion-experience-of-a-single-center-and-review-of-literature
#16
Peng Gao, Yabing Wang, Yan Ma, Qi Yang, Haiqing Song, Yanfei Chen, Liqun Jiao, Adnan I Qureshi
OBJECTIVE: The optimal treatment of chronic symptomatic total occlusion of the intracranial vertebral artery (ICVA) remains undefined. We report a single-center experience of endovascular recanalization for patients with chronic symptomatic ICVA occlusion who were refractory to medical therapy. METHODS: From Jan 2009 to Jan 2017, we retrospectively reviewed 14 consecutive patients presenting with recurrent symptoms attributed to the chronic ICVA occlusion. We searched previous literature using PubMed databases during the same period as comparison...
February 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29406718/metabolomics-analysis-reveals-that-ethylene-and-methyl-jasmonate-regulate-different-branch-pathways-to-promote-the-accumulation-of-terpenoid-indole-alkaloids-in-catharanthus-roseus
#17
Xiao-Ning Zhang, Jia Liu, Yang Liu, Yu Wang, Ann Abozeid, Zhi-Guo Yu, Zhong-Hua Tang
The medicinal plant Catharanthus roseus accumulates large numbers of terpenoid indole alkaloids (TIAs), including the pharmaceutically important vinblastine, vincristine, ajmalicine, and serpentine. The phytohormone ethylene or methyl jasmonate (MeJA) can markedly enhance alkaloid accumulation. The interaction between ethylene or MeJA in the regulation of TIA biosynthesis in C. roseus is unknown. Here, a metabolomics platform is reported that is based on liquid chromatography (LC) coupled with time-of-flight mass spectrometry to study candidate components for TIA biosynthesis, which is controlled by ethylene or MeJA in C...
February 6, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29404578/quality-of-care-for-veterans-with-transient-ischemic-attack-and-minor-stroke
#18
Dawn M Bravata, Laura J Myers, Greg Arling, Edward J Miech, Teresa Damush, Jason J Sico, Michael S Phipps, Alan J Zillich, Zhangsheng Yu, Mathew Reeves, Linda S Williams, Jason Johanning, Seemant Chaturvedi, Fitsum Baye, Susan Ofner, Curt Austin, Jared Ferguson, Glenn D Graham, Rachel Rhude, Chad S Kessler, Donald S Higgins, Eric Cheng
Importance: The timely delivery of guideline-concordant care may reduce the risk of recurrent vascular events for patients with transient ischemic attack (TIA) and minor stroke. Although many health care organizations measure stroke care quality, few evaluate performance for patients with TIA or minor stroke, and most include only a limited subset of guideline-recommended processes. Objective: To assess the quality of guideline-recommended TIA and minor stroke care across the Veterans Health Administration (VHA) system nationwide...
February 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29402710/safety-and-utility-of-dobutamine-and-pressure-wire-use-in-the-hemodynamic-assessment-of-low-flow-low-gradient-aortic-stenosis-with-reduced-left-ventricular-ejection-fraction
#19
Zaher Fanari, Prasad C Gunasekaran, Arslan Shaukat, Sumaya Hammami, Buddhadeb Dawn, Mark Wiley, Peter Tadros
BACKGROUND: The ACC/AHA guidelines recommend low-dose dobutamine challenge for hemodynamic assessment of the severity of AS in patients with low flow, low gradient aortic stenosis with reduced ejection fraction (EF) (LFLG-AS; stage D2). Inherent pitfalls of echocardiography could result in inaccurate aortic valve areas (AVA), which have downstream prognostic implications. Data on the safety and efficacy of coronary pressure wire and fluid-filled catheter use for low dose dobutamine infusion is sparse...
October 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29402065/incidental-statin-use-and-the-risk-of-stroke-or-transient-ischemic-attack-after-radiotherapy-for-head-and-neck-cancer
#20
Daniel Addison, Patrick R Lawler, Hamed Emami, Sumbal A Janjua, Pedro V Staziaki, Travis R Hallett, Orla Hennessy, Hang Lee, Bálint Szilveszter, Michael Lu, Negar Mousavi, Matthew G Nayor, Francesca N Delling, Javier M Romero, Lori J Wirth, Annie W Chan, Udo Hoffmann, Tomas G Neilan
BACKGROUND AND PURPOSE: Interventions to reduce the risk for cerebrovascular events (CVE; stroke and transient ischemic attack [TIA]) after radiotherapy (RT) for head and neck cancer (HNCA) are needed. Among broad populations, statins reduce CVEs; however, whether statins reduce CVEs after RT for HNCA is unclear. Therefore, we aimed to test whether incidental statin use at the time of RT is associated with a lower rate of CVEs after RT for HNCA. METHODS: From an institutional database we identified all consecutive subjects treated with neck RT from 2002 to 2012 for HNCA...
January 2018: Journal of Stroke
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