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https://www.readbyqxmd.com/read/29678934/neutrophil-counts-neutrophil-ratio-and-new-stroke-in-minor-ischemic-stroke-or-tia
#1
Bihong Zhu, Yuesong Pan, Jing Jing, Xia Meng, Xingquan Zhao, Liping Liu, David Wang, S Claiborne Johnston, Hao Li, Yilong Wang, Zhimin Wang, Yongjun Wang
OBJECTIVE: Evidence about whether neutrophil counts or neutrophil ratio is associated with new stroke is scant. The aim of this study is to assess the association of neutrophil counts or neutrophil ratio with a new stroke in patients with minor stroke or TIA. METHODS: We derived data from the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 4 groups according to the quartile of neutrophil counts or neutrophil ratio...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29673823/carotid-artery-endarterectomy-cea-vs-carotid-artery-stenting-cas-for-restenosis-after-cea-a-systematic-review-and-meta-analysis
#2
REVIEW
Pavlos Texakalidis, Stefanos Giannopoulos, Anil K Jonnalagadda, Damianos G Kokkinidis, Theofilos Machinis, John Reavey-Cantwell, Ehrin J Armstrong, Pascal Jabbour
BACKGROUND: Carotid artery restenosis may occur following ipsilateral carotid endarterectomy (CEA). It remains unclear whether carotid artery stenting (CAS) or a repeat CEA (redoCEA) is the best treatment strategy for carotid artery restenosis. OBJECTIVE: We sought to find whether CAS or redoCEA is the optimal therapy for post-endarterectomy carotid restenosis. METHODS: This study was performed according to the PRISMA and MOOSE guidelines...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29672624/anatomical-distribution-of-cerebral-microbleeds-and-intracerebral-hemorrhage-in-vertebrobasilar-dolichoectasia
#3
Alex Förster, Ralf Wenz, Máté Elöd Maros, Johannes Böhme, Mansour Al-Zghloul, Angelika Alonso, Christoph Groden, Holger Wenz
OBJECTIVES: Vertebrobasilar dolichoectasia (VBD) is a dilatative arteriopathy associated with intracerebral hemorrhage. In the present study, we sought to evaluate the frequency and anatomical distribution of cerebral microbleeds (cMBs) and intracerebral hemorrhage (ICH) in VBD. METHODS: From a MRI database 94 VBD patients were identified and analyzed with special emphasis on cMBs and ICH on T2*-weighted gradient echo images (GRE) in relation to the established diagnostic MRI criteria of VBD (diameter, height, and lateral position)...
2018: PloS One
https://www.readbyqxmd.com/read/29671586/a-zirconium-photosensitizer-with-a-long-lived-excited-state-mechanistic-insight-into-photo-induced-single-electron-transfer
#4
Yu Zhang, Tia S Lee, Jeffrey L Petersen, Carsten Milsmann
Time-resolved emission spectroscopy for the luminescent zirconium complex Zr(Me PDP)2 (Me PDP = 2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine) revealed a long-lived excited state with a lifetime τ = 325 ± 10 μs. Computational studies using time-dependent density functional theory (TD-DFT) were conducted to identify the nature of the luminescent excited state as a mixed triplet intraligand/ligand-to-metal charge transfer (3 IL/3 LMCT) state. Stern-Volmer experiments showed a strong dependence of the quenching rate on the redox potential of the quencher indicating photo-induced single electron transfer (SET) as the quenching pathway...
April 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29669909/time-course-of-blood-pressure-control-prior-to-lacunar-tia-and-stroke-population-based-study
#5
Linxin Li, Sarah J V Welch, Sergei A Gutnikov, Ziyah Mehta, Peter M Rothwell
OBJECTIVE: To determine the age-specific temporal trends in blood pressure (BP) before acute lacunar vs nonlacunar TIA and stroke. METHODS: In a population-based study of TIA/ischemic stroke (Oxford Vascular Study), we studied 15-year premorbid BP readings from primary care records in patients with lacunar vs nonlacunar events (Trial of Org 10172 in Acute Stroke Treatment [TOAST]) stratified by age (<65, ≥65 years). RESULTS: Of 2,085 patients (1,250 with stroke, 835 with TIA), 309 had lacunar events...
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29663763/catheter-based-left-atrial-appendage-closure
#6
Ketil Lunde, Ahmed Al-Ani, Reidar Bjørnerheim, Anders Hervold, Anders Opdahl, Jan Otto Beitnes
BAKGRUNN: Atrieflimmer er en vanlig tilstand i befolkningen og gir økt risiko for hjerneslag. Antikoagulasjonsbehandling er effektivt for å forebygge tromboembolisme ved atrieflimmer, men av ulike grunner blir mange atrieflimmerpasienter med indikasjon for antikoagulasjonsbehandling ikke behandlet. Kateterbasert lukking av venstre atriums aurikkel er en ny metode for å forebygge hjerneslag ved atrieflimmer. MATERIALE OG METODE: I perioden september 2014-april 2016 gjennomgikk 27 pasienter med atrieflimmer og høy risiko for hjerneslag forsøk på kateterbasert lukking av venstre atriums aurikkel ved Oslo universitetssykehus...
April 17, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29661894/clinical-reasoning-a-56-year-old-woman-with-acute-vertigo-and-diplopia
#7
Rishi Sharma, Tia Chakraborty, Francis K Buadi, Elena Beam, Vincent S Pureza, Gabriel L Pagani-Estevez, Eoin P Flanagan
No abstract text is available yet for this article.
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29660843/mortality-after-a-cerebrovascular-event-in-age-related-macular-degeneration-patients-treated-with-bevacizumab-ocular-injections
#8
Joel Hanhart, Doron S Comaneshter, Shlomo Vinker
PURPOSE: To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed with stroke or transient ischaemic attack (TIA). METHODS: We reviewed bevacizumab-treated AMD patients with a diagnosis of stroke or TIA prior to their first bevacizumab injection (n = 948). Those patients, naïve to any anti-vascular endothelial growth factor (anti-VEGF) at the time of stroke/TIA, were then compared to age- and gender-matched patients who had a stroke/TIA at the same time and had never been exposed to anti-VEGF...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29660221/brainstem-leukoaraiosis-independently-predicts-poor-outcome-after-ischemic-stroke
#9
Eva Giralt-Steinhauer, Santiago Medrano, Carolina Soriano-Tárraga, Marina Mola-Caminal, Raquel Rasal, Elisa Cuadrado-Godia, Ana Rodríguez-Campello, Angel Ois, J Capellades, Jordi Jimenez-Conde, Jaume Roquer
BACKGROUND: Increased supratentorial white matter hyperintensities volume (S-WMHV) has been reported as a predictor of worse outcome in acute ischemic stroke (AIS) patients. However, few studies focus on less common locations such as brainstem-white matter hyperintensities (B-WMH), and their relationship with S-WMHV. This study aimed to examine whether B-WMH affects clinical outcome after AIS or transient ischemic attack (TIA). METHODS: Based on MRI evidence, B-WMH was evaluated in 313 prospectively identified patients with AIS/TIA and registered as absent or present...
April 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29659795/managing-uncertainty-a-qualitative-study-of-gps-views-on-the-diagnosis-and-immediate-management-of-transient-ischaemic-attack-and-the-potential-of-a-diagnostic-tool
#10
Priyanka Bose, Carolyn Tarrant, Amit K Mistri, Andrew Wilson
Background: Most patients with transient ischaemic attack (TIA) present to their GP. Early identification and treatment reduces the risk of subsequent stroke and consequent disability and mortality. Objective: To explore GPs' views on the diagnosis and immediate management of suspected TIA, and the potential utility of a diagnostic tool. Methods: This is a qualitative interview study based in Leicestershire, UK. A purposive sample of 10 GPs participated in 30-minute semi-structured telephone interviews...
April 12, 2018: Family Practice
https://www.readbyqxmd.com/read/29653415/carotid-arteritis-causing-amaurosis-fugax-and-ischaemic-cerebrovascular-events-in-neurosarcoidosis
#11
D P Kidd, D J McCabe, T Wilhelm, M Galloway
OBJECTIVE: To present and review the vascular consequences of arteritis in neurosarcoidosis. PATIENT AND METHODS: neurosarcoidosis is typically an inflammatory disorder of the meninges surrounding the brain and spinal cord. Although inflammation of small and medium sized vessels is seen pathologically and vasculitis is occasionally described, a large intracerebral arteritis has not previously been reported. A few case reports exist, however, which describe the vascular consequences of large vessel compromise in the disorder...
March 22, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29649819/patent-foramen-ovale-and-cryptogenic-stroke-or-transient-ischemic-attack-to-close-or-not-to-close-a-systematic-review-and-meta-analysis
#12
Simona Lattanzi, Francesco Brigo, Claudia Cagnetti, Mario Di Napoli, Mauro Silvestrini
BACKGROUND: The optimal strategy of secondary stroke prevention in patients with patent foramen ovale (PFO) is controversial. This study was performed to evaluate the efficacy and safety of the device closure (DC) versus the medical therapy (MT) in patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO. SUMMARY: Randomized controlled trials with active and control groups receiving the DC plus MT and MT alone in patients with history of cryptogenic stroke/TIA and diagnosis of PFO were systematically searched...
April 12, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29644412/patent-foramen-ovale-closure-versus-medical-therapy-for-prevention-of-recurrent-cryptogenic-embolism-updated-meta-analysis-of-randomized-clinical-trials
#13
Brunilda Alushi, Alexander Lauten, Salvatore Cassese, Roisin Colleran, Stefanie Schüpke, Himanshu Rai, Heribert Schunkert, Bernhard Meier, Ulf Landmesser, Adnan Kastrati
BACKGROUND: We performed an updated meta-analysis of all randomized-controlled trials (RCTs) comparing patent foramen ovale (PFO) closure with medical therapy for prevention of recurrent ischemic stroke. METHODS AND RESULTS: We searched Medline, EMBASE, and Cochrane databases, and proceedings of international meetings for RCTs of patients with cryptogenic stroke and PFO comparing percutaneous PFO closure versus medical therapy for prevention of recurrent ischemic stroke...
April 11, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29643080/periodic-limb-movements-during-sleep-in-stroke-tia-prevalence-course-and-cardiovascular-burden
#14
Mauro Manconi, Francesco Fanfulla, Raffaele Ferri, Silvia Miano, Josè Haba-Rubio, Raphael Heinzer, Thomas Horvath, Paola Proserpio, Peter Young, Giorgio Moschovitis, Andrea Seiler, Carlo Cereda, Lino Nobili, Roland Wiest, Sebastian R Ott, Claudio L Bassetti
OBJECTIVE: To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA. METHODS: Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation in the acute and chronic phases after stroke/TIA, together with a MRI brain scan and a 24-hour blood pressure evaluation...
April 11, 2018: Neurology
https://www.readbyqxmd.com/read/29642839/tia-algorithms-for-development-of-identity-linked-snp-islands-for-analysis-by-massively-parallel-dna-sequencing
#15
M Heath Farris, Andrew R Scott, Pamela A Texter, Marta Bartlett, Patricia Coleman, David Masters
BACKGROUND: Single nucleotide polymorphisms (SNPs) located within the human genome have been shown to have utility as markers of identity in the differentiation of DNA from individual contributors. Massively parallel DNA sequencing (MPS) technologies and human genome SNP databases allow for the design of suites of identity-linked target regions, amenable to sequencing in a multiplexed and massively parallel manner. Therefore, tools are needed for leveraging the genotypic information found within SNP databases for the discovery of genomic targets that can be evaluated on MPS platforms...
April 11, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29642709/thromboembolism-and-mortality-in-the-tasmanian-atrial-fibrillation-study
#16
Endalkachew Admassie, Leanne Chalmers, Luke R Bereznicki
BACKGROUND: Although utilization of anticoagulation in patients with atrial fibrillation (AF) has increased in recent years, contemporary data regarding thromboembolism and mortality incidence rates are limited outside of clinical trials. This study aimed to investigate the impact of the direct oral anticoagulants (DOACs) on the clinical outcomes of patients with AF included in the Tasmanian Atrial Fibrillation Study. METHODS: The medical records of all patients with a primary or secondary diagnosis of AF who presented to public hospitals in Tasmania, Australia, between 2011 and 2015, were retrospectively reviewed...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29629065/carotid-arterial-stent-implantation-follow-up-and-results-in-50-patients-preliminary-report
#17
Alireza Khosravi, Fereshteh Ziaee Bideh, Farshad Roghani, Mohammad Saadatnia, Fariborz Khorvash, Majid Nejati, Nastaran Khoshpour, Mohaddeseh Behjati
Background: Carotid artery stenting (CAS) is considered as a safe and effective procedure for treatment of carotid artery stenosis. Evaluation of this procedure's complications is essential for proper clinical decision-making. Objective: This study aimed to evaluate the cardiovascular events after CAS among our patients in Isfahan, Iran. Methods: This case-series study was conducted on fifty patients from December 2013 to May 2016. These patients were referred to the cardiology centers of Isfahan, Iran by a neurologist, for stenting of extracranial carotid arteries...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29628466/increase-carotid-flow-by-double-sheath-connection-technique-to-reduce-cerebral-ischemia-for-transcatheter-aortic-valve-implantation-through-transcarotid-approach
#18
Richard Tsai, I-Ming Chen, Po-Lin Chen, Hsin-Bang Leu, Ying-Hwa Chen, Hsiao-Huang Chang
PURPOSE: Transcarotid transcatheter aortic valve implantation (TAVI) is one alternative approach if unfavorable femoral access. However, this approach may cause cerebral vascular accidents (CVAs) by temporarily occluding common carotid artery (CCA). The purpose of this study is to develop a new method reducing cerebral ischemia during transcarotid TAVI. METHODS: We inserted an 8- and 18-Fr. sheath in CCA with tip toward brain and aortic arch, respectively, and connected their side arms to create a bypass flow...
April 6, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29628278/left-atrial-dilatation-a-target-organ-damage-in-young-to-middle-age-hypertensive-patients-the-campania-salute-network
#19
Costantino Mancusi, Grazia Canciello, Raffaele Izzo, Silvia Damiano, Maria Gabriella Grimaldi, Nicola de Luca, Giovanni de Simone, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Left atrial (LA) volume is a predictor of outcome in hypertension. It is unclear whether or not this effect depends on coexisting target organ damage (TOD). PURPOSE: To investigate whether LA volume predicts outcome independently of TOD [left ventricular (LV) hypertrophy (LVH) and/or carotid plaque] in a registry of hypertensive treated patients. METHODS: From the Campania Salute Network registry, we selected 5844 young adult hypertensive patients <65 years old (mean age 50 ± 9 years, 41% women, 8% diabetic) without prevalent CV or valvular heart disease more than mild, with normal LV ejection fraction, stage III or less CKD and available follow-up...
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29627025/cerebrovascular-imaging-of-cerebral-ischemia-in-acute-type-a-aortic-dissection
#20
Soichiro Matsubara, Masatoshi Koga, Tomoyuki Ohara, Yasuyuki Iguchi, Kenji Minatoya, Yoshio Tahara, Tetsuya Fukuda, Yuichi Miyazaki, Katsufumi Kajimoto, Yuki Sakamoto, Naoki Makita, Naoki Tokuda, Kazuyuki Nagatsuka, Yukio Ando, Kazunori Toyoda
BACKGROUND AND PURPOSE: Stanford type A aortic dissection (AAD) sometimes causes acute ischemic stroke (AIS) or transient ischemic attack (TIA). There is little understanding of cerebrovascular imaging of AIS or TIA in patients with AAD. METHODS: Consecutive AIS/TIA patients with AAD who were admitted within 4.5 h of onset were reviewed. We compared findings of MRI/MRA between these and consecutive AIS/TIA patients without AAD within 4.5 h of onset. RESULTS: Seventeen AAD and 249 non-AAD patients were identified...
May 15, 2018: Journal of the Neurological Sciences
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