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https://www.readbyqxmd.com/read/29212745/factors-associated-with-focal-computed-tomographic-perfusion-abnormalities-in-supratentorial-transient-ischemic-attacks
#1
Ivo A Meyer, Carlo W Cereda, Pamela N Correia, Jean-Baptiste Zerlauth, Francesco Puccinelli, David C Rotzinger, Michael Amiguet, Philippe Maeder, Reto A Meuli, Patrik Michel
BACKGROUND AND PURPOSE: Computed tomographic perfusion (CTP) is useful in diagnosis of patients with transient focal neurological symptoms. In acute imaging of patients with a suspected transient ischemic attack (TIA), it remains unclear which patients develop focal perfusion abnormalities (FPA), that is, hypoperfusion or hyperperfusion. We aimed at determining independent factors associated with FPA in patients with supratentorial TIAs. METHODS: We prospectively collected consecutive patients with supratentorial TIAs defined by the traditional time-based definition who underwent CTP within 24 hours of symptom onset...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29210105/systematic-review-and-meta-analysis-of-diagnostic-accuracy-of-serum-refractometry-and-brix-refractometry-for-the-diagnosis-of-inadequate-transfer-of-passive-immunity-in-calves
#2
REVIEW
S Buczinski, E Gicquel, G Fecteau, Y Takwoingi, M Chigerwe, J M Vandeweerd
BACKGROUND: Transfer of passive immunity in calves can be assessed by direct measurement of immunoglobulin G (IgG) by methods such as radial immunodiffusion (RID) or turbidimetric immunoassay (TIA). IgG can also be measured indirectly by methods such as serum refractometry (REF) or Brix refractometry (BRIX). OBJECTIVES: To determine the accuracy of REF and BRIX for assessment of inadequate transfer of passive immunity (ITPI) in calves. DESIGN: Systematic review and meta-analysis of diagnostic accuracy studies...
December 5, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29206729/extracorporeal-cardiopulmonary-resuscitation-in-the-pediatric-cardiac-population-in-search-of-a-standard-of-care
#3
Javier J Lasa, Parag Jain, Tia T Raymond, Charles G Minard, Alexis Topjian, Vinay Nadkarni, Michael Gaies, Melania Bembea, Paul A Checchia, Lara S Shekerdemian, Ravi Thiagarajan
OBJECTIVES: Although clinical and pharmacologic guidelines exist for the practice of cardiopulmonary resuscitation in children (Pediatric Advanced Life Support), the practice of extracorporeal cardiopulmonary resuscitation in pediatric cardiac patients remains without universally accepted standards. We aim to explore variation in extracorporeal cardiopulmonary resuscitation procedures by surveying clinicians who care for this high-risk patient population. DESIGN: A 28-item cross-sectional survey was distributed via a web-based platform to clinicians focusing on cardiopulmonary resuscitation practices and extracorporeal membrane oxygenation team dynamics immediately prior to extracorporeal membrane oxygenation cannulation...
December 4, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29205668/cerebrovascular-blood-pressure-autoregulation-monitoring-and-postoperative-transient-ischemic-attack-in-pediatric-moyamoya-vasculopathy
#4
Jennifer K Lee, Monica Williams, Michael Reyes, Edward S Ahn
BACKGROUND: Children with moyamoya vasculopathy are at high risk of perioperative cerebral ischemia or hyperperfusion. Maintaining blood pressure within the range of functional cerebrovascular blood pressure autoregulation might reduce the risk of perioperative neurologic injury. AIMS: We tested whether blood pressure autoregulation is associated with postoperative transient ischemic attack in a study of patients with pediatric moyamoya vasculopathy. METHODS: We conducted an observational study of 15 pediatric patients undergoing surgical revascularization with pial synangiosis...
December 5, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29204116/p2y12-receptor-antagonist-clopidogrel-does-not-contribute-to-risk-of-osteoporotic-fractures-in-stroke-patients
#5
Niklas R Jørgensen, Peter Schwarz, Helle K Iversen, Peter Vestergaard
Background: Stroke is a leading cause of mortality and morbidity. It is associated with excessive bone loss and risk of fracture in stroke patients is high. The P2Y12R antagonist and platelet inhibitor, clopidogrel, is widely used for secondary prevention after a stroke. However, recent studies have shown that clopidogrel has negative effects on bone and that long-term clopidogrel use is associated with increased fracture risk. The purpose of the current study was therefore to investigate the association of clopidogrel treatment with risk of fractures in stroke and TIA patients...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29202727/atrial-fibrillation-is-not-uncommon-among-patients-with-ischemic-stroke-and-transient-ischemic-stroke-in-china
#6
Xiaomeng Yang, Shuya Li, Xingquan Zhao, Liping Liu, Yong Jiang, Zixiao Li, Yilong Wang, Yongjun Wang
BACKGROUND: Atrial fibrillation (AF) is reported to be a less frequent cause of ischemic stroke in China than in Europe and North America, but it is not clear whether this is due to underestimation. Our aim was to define the true frequency of AF-associated stroke, to determine the yield of 6-day Holter ECG to detect AF in Chinese stroke patients, and to elucidate predictors of newly detected AF. METHODS: Patients with acute ischemic stroke or transient ischemic attack (TIA) were enrolled in a prospective, multicenter cohort study of 6-day Holter monitoring within 7 days after stroke onset at 20 sites in China between 2013 and 2015...
December 4, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29197071/peroxisome-proliferator-activated-receptor-gamma-agonists-for-preventing-recurrent-stroke-and-other-vascular-events-in-people-with-stroke-or-transient-ischaemic-attack
#7
REVIEW
Jia Liu, Lu-Ning Wang
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists are insulin-sensitising drugs used for the treatment of insulin resistance. In addition to lowering glucose in diabetes, these drugs may also protect against hyperlipidaemia and arteriosclerosis, which are risk factors for stroke. This is an update of a review first published in January 2014 and subsequently updated in October 2015. OBJECTIVES: To assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular events for people with stroke or transient ischaemic attack (TIA)...
December 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29196251/effectiveness-of-ipsilateral-stroke-prevention-between-conservative-management-and-indirect-revascularization-for-moyamoya-disease-mmd-in-a-north-american-cohort
#8
Jose L Porras, Wuyang Yang, Risheng Xu, Tomas Garzon-Muvdi, Justin M Caplan, Geoffrey P Colby, Alexander L Coon, Edward S Ahn, Rafael J Tamargo, Judy Huang
BACKGROUND: Few reports compare surgical intervention with conservative treatment for moyamoya disease (MMD) in non-Asian cohorts. This study describes the effectiveness of follow-up stroke prevention by indirect revascularization relative to conservative management in a Northeast United States study population. METHOD: We retrospectively reviewed records of patients with MMD at our institution from 1990-2014. Baseline characteristics and follow-up results including subsequent ipsilateral strokes were collected, and compared between an indirect revascularization group and a conservatively managed group on a per-hemisphere basis...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29194197/diurnal-variation-of-optical-coherence-tomography-measurements-of-static-and-dynamic-anterior-segment-parameters
#9
Benjamin Y Xu, Rafaella Cleto Penteado, Robert Neal Weinreb
PURPOSE: To examine the diurnal variation of static and dynamic anterior segment parameters in young, healthy eyes by comparing anterior segment optical coherence tomography (AS-OCT) measurements obtained in the morning and evening and also in the light and dark. METHODS: Twenty-two subjects ranging from ages 19 to 47 years with no past ocular history were selected (12 male, 10 female; mean age 34.2 y). Imaging was performed with the Tomey CASIA2 AS-OCT device in two fixed lighting environments, light and dark, between the hours of 0830 to 1000 and 1730 to 1900...
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29183926/protocol-for-a-feasibility-randomised-controlled-trial-of-screening-and-enhanced-risk-management-for-vascular-event-related-decline-in-memory-served-memory
#10
Phyo Kyaw Myint, Yoon K Loke, William Davison, Katharina Mattishent, George Christopher Fox, Robert Fleetcroft, David Turner, Lee Shepstone, John F Potter
INTRODUCTION: Stroke is a leading cause of death and disability. The development of dementia after stroke is common. Vascular risk factors (VRF) which contribute to stroke risk can also contribute to cognitive decline, especially in vascular dementia (VaD). There is no established treatment for VaD, therefore strategies for prevention could have major health resource implications. This study was designed to assess whether patients with early cognitive decline after stroke/transient ischaemic attack (TIA) can be easily identified and whether target-driven VRF management can prevent progression to dementia...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29182713/the-direct-effects-of-plant-polyploidy-on-the-legume-rhizobia-mutualism
#11
Nicole J Forrester, Tia-Lynn Ashman
Background: Polyploidy is known to significantly alter plant genomes, phenotypes and interactions with the abiotic environment, yet the impacts of polyploidy on plant-biotic interactions are less well known. A particularly important plant-biotic interaction is the legume-rhizobia mutualism, in which rhizobia fix atmospheric nitrogen in exchange for carbon provided by legume hosts. This mutualism regulates nutrient cycles in natural ecosystems and provides nitrogen to agricultural environments...
November 22, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29180090/neurological-deterioration-in-patients-with-moyamoya-disease-during-pregnancy-delivery-and-puerperium
#12
Wonhyoung Park, Jae Sung Ahn, Jaewoo Chung, Yeongu Chung, Seungjoo Lee, Jung Cheol Park, Byung Duk Kwun
BACKGROUND: We reviewed our clinical experience of patients with moyamoya disease (MMD) who gave birth and assessed characteristics of those experiencing neurological deterioration. METHODS: The patients were classified into patients diagnosed with MMD during pregnancy and puerperium (Group 1) and those diagnosed before pregnancy (Group 2). We retrospectively reviewed patient characteristics, MMD treatment, neurological symptoms before and during pregnancy and/after puerperium, obstetrical history, and delivery type in Groups 1 and 2...
November 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29178152/identification-characterization-and-distribution-of-terpene-indole-alkaloids-in-ethanolic-extracts-of-catharanthus-roseus-using-hplc-esi-qtof-ms-ms-and-the-study-of-their-geographical-variation
#13
Sunil Kumar, Vikas Bajpai, Awantika Singh, Brijesh Kumar
RATIONALE: Catharanthus roseus is a well-known dicotyledonous medicinal plant containing diverse classes of bioactive terpene indole alkaloids (TIAs), in particular the anticancer agents, vinblastine and vincristine. In view of the commercial importance of these compounds there is an urgent need to develop an accurate and reliable method for the screening of TIAs from C. roseus. METHODS: A method for the separation and characterization of these compounds was developed using high performance liquid chromatography coupled with positive electrospray ionization quadrupole time of flight tandem mass spectrometry (HPLC/ESI-QTOF-MS/MS)...
November 26, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29175888/when-has-service-provision-for-transient-ischaemic-attack-improved-enough-a-discrete-event-simulation-economic-modelling-study
#14
Pelham Barton, James P Sheppard, Cristina M Penaloza-Ramos, Sue Jowett, Gary A Ford, Daniel Lasserson, Jonathan Mant, Ruth M Mellor, Tom Quinn, Peter M Rothwell, David Sandler, Don Sims, Richard J McManus
OBJECTIVES: The aim of this study was to examine the impact of transient ischaemic attack (TIA) service modification in two hospitals on costs and clinical outcomes. DESIGN: Discrete event simulation model using data from routine electronic health records from 2011. PARTICIPANTS: Patients with suspected TIA were followed from symptom onset to presentation, referral to specialist clinics, treatment and subsequent stroke. INTERVENTIONS: Included existing versus previous (less same day clinics) and hypothetical service reconfiguration (7-day service with less availability of clinics per day)...
November 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/29174475/temporal-trends-in-the-premorbid-use-of-preventive-treatments-in-patients-with-acute-ischemic-cerebrovascular-events-and-a-history-of-vascular-disease-the-dijon-stroke-registry-1985-2010
#15
Catia Khoumri, Henri Bailly, Benoit Delpont, Benoit Daubail, Christelle Blanc, Cécile Chazalon, Jérôme Durier, Marie Hervieu-Bègue, Guy-Victor Osseby, Olivier Rouaud, Maurice Giroud, Catherine Vergely, Yannick Béjot
INTRODUCTION: Although secondary prevention in patients with arterial vascular diseases has improved, a gap between recommendations and clinical practice may exist. OBJECTIVES: We aimed to evaluate temporal trends in the premorbid use of preventive treatments in patients with ischemic cerebrovascular events (ICVE) and prior vascular disease. METHODS: Patients with acute ICVE (ischemic stroke/TIA) were identified through the population-based stroke registry of Dijon, France (1985-2010)...
November 22, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29163346/paroxysmal-symptoms-as-the-first-manifestation-of-multiple-sclerosis-mimicking-a-transient-ischemic-attack-a-report-of-two-cases
#16
Yao Zhang, Siyuan Fan, Fei Han, Yan Xu
Paroxysmal symptoms are unusual manifestations of multiple sclerosis (MS). When presented as the first clinical manifestation, paroxysmal symptoms may easily be mistaken for transient ischemic attack (TIA). Previously, several cases of MS that reported with paroxysmal symptoms were misdiagnosed as TIA. Here, we report two additional cases, focusing on the clinical characteristics of paroxysmal symptoms in MS. Both cases had paroxysmal symptoms as their first manifestation; one presented with transient dizziness, left face numbness, and right limb weakness, and the other presented with episodic lightheadedness, blurred vision, nausea, palpitations, and tremulousness upon standing...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29160893/sers-in-biology-biomedical-sers-general-discussion
#17
Jeremy Baumberg, Steven Bell, Alois Bonifacio, Rohit Chikkaraddy, Malama Chisanga, Stella Corsetti, Ines Delfino, Olga Eremina, Claudia Fasolato, Karen Faulds, Holly Fleming, Roy Goodacre, Duncan Graham, Mike Hardy, Lauren Jamieson, Tia Keyes, Agata Królikowska, Christian Kuttner, Judith Langer, Carin Lightner, Sumeet Mahajan, Jean-Francois Masson, Howbeer Muhamadali, Michael Natan, Fay Nicolson, Evelina Nikelshparg, Konstantinos Plakas, Jürgen Popp, Marc Porter, Daniel Prezgot, Nathalie Pytlik, Sebastian Schlücker, Alessandro Silvestri, Nick Stone, Zhong-Qun Tian, Ashish Tripathi, Marjorie Willner, Pieter Wuytens
No abstract text is available yet for this article.
November 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/29158448/executive-function-declines-in-the-first-6-months-after-a-transient-ischemic-attack-or-transient-neurological-attack
#18
Frank G van Rooij, Nicole O Plaizier, Sarah E Vermeer, Bozena M Góraj, Peter J Koudstaal, Edo Richard, Frank-Erik de Leeuw, Roy P C Kessels, Ewoud J van Dijk
BACKGROUND AND PURPOSE: Although by definition transient, both transient ischemic attack (TIA) and transient neurological attack (TNA) are associated with cognitive impairment. Determinants and course of cognitive function afterward are, however, unclear. We prospectively determined cognitive performance after TIA and TNA in relation to clinical diagnosis and diffusion-weighted imaging (DWI) results. METHODS: TIA and TNA patients aged ≥45 years without prior stroke or dementia underwent comprehensive cognitive assessment and magnetic resonance imaging within 7 days after the qualifying event...
November 20, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29158247/predictive-values-of-referrals-for-transient-ischaemic-attack-from-first-contact-health-care-a-systematic-review
#19
Rebecca Kandiyali, Daniel S Lasserson, Penny Whiting, Alison Richards, Jonathan Mant
BACKGROUND: Over 150 000 cases of suspected transient ischaemic attack (TIA) are referred to outpatient clinics in England each year. The majority of referrals are made by GPs. AIM: This study aimed to identify how many patients referred to a TIA clinic actually have TIA (that is, calculate the positive predictive value [PPV] of first-contact healthcare referral) and to record the alternative diagnoses in patients without TIA, in order to determine the optimal service model for patients with suspected TIA...
November 20, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29151682/anterior-segment-morphology-in-primary-angle-closure-glaucoma-using-ultrasound-biomicroscopy
#20
Tarannum Mansoori, Nagalla Balakrishna
Aim: To evaluate the configuration of the anterior chamber angle quantitatively and study the morphological changes in the eye with ultrasound biomicroscopy (UBM) in primary angle closure glaucoma (PACG) patients after laser peripheral iridotomy (LPI). Materials and methods: A total of 185 eyes of 185 PACG patients post-LPI and 126 eyes of 126 normal subjects were included in this prospective study. All subjects underwent complete ophthalmic evaluation, A-scan biometry, and UBM...
September 2017: Journal of Current Glaucoma Practice
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