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ground glass nodule

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https://www.readbyqxmd.com/read/29153815/en-bloc-upper-and-lower-lobe-trisegmentectomy-facilitated-by-displaced-segmental-airway
#1
Akifumi Nakamura, Shun-Ichi Watanabe, Yukio Watanabe, Keisuke Asakura, Kazuo Nakagawa
A 66-year-old woman was referred to our hospital. Computed tomography revealed a partly solid ground-glass nodule located in the left S(1+2) and spread over the left S(6). Pathologic diagnosis was primary adenocarcinoma (c-T2a N0 M0 c-stage IB). The left B(1+2) arose from the left main bronchus and was displaced superiorly behind the left main pulmonary artery. Severely incomplete lobulation was also recognized. We performed trisegmentectomy, and negative margins were confirmed. The patient is now asymptomatic without recurrence...
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29150624/semiquantative-visual-assessment-of-sub-solid-pulmonary-nodules-%C3%A2-3%C3%A2-cm-in-differentiation-of-lung-adenocarcinoma-spectrum
#2
Fu-Zong Wu, Po-An Chen, Carol C Wu, Pei-Lun Kuo, Shu-Ping Tsao, Chu-Chun Chien, En-Kuei Tang, Ming-Ting Wu
We aimed to analyze CT features of persistent subsolid nodules (SSN) ≦3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate whether parameters enable distinction between invasive pulmonary adenocarcinomas (IPAs) and pre-invasive lesions. A total of 129 patients with 141 SSNs confirmed with surgically pathologic proof were retrospectively reviewed. Of 141 SSNs, there were 57 pure ground-glass nodules (GGNs), 22 heterogeneous GGNs, and 62 part-solid nodules. SSN subclassification showed a significant linear trend with invasive degree of the adenocarcinoma spectrum (pure GGNs 7%; heterogeneous GGNs 36...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141316/-a-clinical-analysis-of-micafungin-treatment-of-pulmonary-invasive-fungal-infection-in-pediatric-patients-with-acute-leukemia-or-post-hematopoietic-stem-cells-transplantation
#3
K Huang, K Y Qiu, L L Deng, J P Fang, Y Li, H X Guo, D H Zhou
Objective: To investigate the efficacy and safety of micafungin (MCF) for pulmonary invasive fungal disease (PIFD) in pediatric patients with acute leukemia or post hematopoietic stem cells transplantation. Method: Twenty-five neutropenic PIFD children with acute leukemia or post hematopoietic stem cells transplantation in Sun Yat-sen Memorial Hospital of Sun Yat-sen University were selected from January 2012 to June 2015, including 12 males and 13 females, age range 2-15 (average 6.2±2.0) years. There were 12 cases of acute leukemia (AL) after chemotherapy, 4 cases of acute leukemia (AL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and 9 cases of β-thalassemia major after allo-HSCT...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29127699/the-maximum-standardized-uptake-value-of-preoperative-positron-emission-tomography-computed-tomography-in-lung-adenocarcinoma-with-a-ground-glass-opacity-component-of-less-than-30%C3%A2-mm
#4
Bong Y Son, Sukki Cho, Sung W Yum, Kwhanmien Kim, Sanghoon Jheon
BACKGROUND AND OBJECTIVES: This study evaluated the relationship between the maximum standardized uptake value (SUVmax) of preoperative positron emission tomography/computed tomography (PET/CT) and the characteristics of lung adenocarcinoma featuring ground-glass opacity nodules (GGN). METHODS: The association of the SUVmax of preoperative PET/CT with ground-glass opacity (GGO) proportion on CT, subtypes of adenocarcinoma (minimally invasive adenocarcinoma, invasive adenocarcinoma), predominant types of invasive adenocarcinoma, and size of the total and invasive components of pathology were evaluated in 190 patients who underwent resection for lung adenocarcinoma featuring GGN...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29114470/histopathologic-and-molecular-approach-to-staging-of-multiple-lung-nodules
#5
REVIEW
Frank Schneider, Sanja Dacic
Distinguishing multiple primary lung cancers from intrapulmonary metastases in patients with synchronous multifocal lung adenocarcinomas can be challenging. The most recent 8th edition American Joint Committee on Cancer staging manual (AJCC staging manual) distinguishes four disease patterns in patients with multiple lung nodules: (I) two or more distinct and histologically different masses (considered unrelated and staged as individual cancers); (II) multiple ground-glass or part-solid nodules, histologically of with lepidic growth pattern (considered separate tumors, T staged based on highest T stage lesion); (III) patchy areas of ground-glass and consolidations, histologically often invasive mucinous adenocarcinomas (considered single tumor with diffuse "pneumonic-type" involvement); and (IV) separate nodules with the same histologic features based on comprehensive histologic subtyping (considered intrapulmonary metastases)...
October 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29104652/plain-and-contrast-enhanced-chest-computed-tomography-scan-findings-of-pulmonary-cryptococcosis-in-immunocompetent-patients
#6
Rongshui Yang, Yan Yan, Yuhuan Wang, Xiaohuan Liu, Xinhui Su
Pulmonary cryptococcosis is most commonly reported in immunocompromised patients, whereas immunocompetent hosts are rarely affected and may be asymptomatic, resulting in reduced diagnostic performance of computed tomography (CT) imaging. Thus, the aim of the present study was to review the plain and contrast-enhanced chest CT scan findings of primary pulmonary cryptococcosis in immunocompetent patients, with the aim of improving the diagnosis of this type of pulmonary disease. In the present study, a total of 27 immunocompetent patients of clinically confirmed pulmonary cryptococcosis were analyzed retrospectively...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29102950/fibrotic-lung-toxicity-induced-by-hydroxycarbamide
#7
Elena Bargagli, Marco Palazzi, Francesco Perri, Elena Torricelli, Elisabetta Rosi, Alessandra Bindi, Massimo Pistolesi, Luca Voltolini
A patient treated for 4 months with hydroxycarbamide (hydroxyurea) for chronic myelomonocytic leukemia was admitted to hospital for recently developed severe dyspnea and acute respiratory failure. The computed tomographic scan of the chest showed diffuse ground glass opacities, some centrilobular low-density nodules (resembling hypersensitivity pneumonitis-like pattern), and minimal interstitial reticulation of the subpleural region. The analysis of bronchoalveolar lavage fluid excluded infection, as did serological examinations...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29098128/hot-tub-lung-a-diagnostic-challenge
#8
Hassaan Yasin, William E Mangano, Paras Malhotra, Ali Farooq, Hesham Mohamed
Hot tub lung (HTL) is a granulomatous lung disease thought to occur as a result of a hypersensitivity response to non-tuberculous mycobacteria (NTM). Typical radiographic findings are diffuse micronodular and/or ground glass opacities. We report an interesting case of HTL that presented with unique radiographic features, making its diagnosis a predicament. A 56-year-old immunocompetent female with chronic dyspnea and dry cough was found to have subcentimeter cavitary nodules, predominantly in the upper lung zones...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29093420/a-case-of-seasonal-influenza-vaccine-induced-pneumonitis-presenting-with-multiple-pulmonary-nodules
#9
Takeshi Numata, Norihito Hida, Kai Yazaki, Naoki Arai, Kyoko Ota, Hidetoshi Yanai, Takeo Endo
A 39-year-old woman received a seasonal influenza vaccine in November 2015 and subsequently experienced malaise, low-grade fever, and chest discomfort. A chest X-ray performed 2 weeks after vaccination showed multiple nodular shadows in both lungs and ground-glass shadows in both lower lung fields. Her bronchoalveolar lavage fluid contained an unusually high number of lymphocytes, and a drug-induced lymphocyte stimulation test for seasonal influenza vaccine was positive. Transbronchial lung biopsy revealed the presence of granulomatous inflammation...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29092754/favorable-prognosis-and-high-discrepancy-of-genetic-features-in-surgical-patients-with-multiple-primary-lung-cancers
#10
Kezhong Chen, Wei Chen, Jianqiao Cai, Fan Yang, Feng Lou, Xun Wang, Jingbo Zhang, Mingyu Zhao, Jay Zhang, Jun Wang
OBJECTIVE: Multiple primary lung cancers are detected with increasing frequency, but the ideal strategy for diagnosis and treatment remains disputable. This study evaluated both clinical characteristics and genetic alterations to investigate the appropriate strategy for patients with multiple primary lung cancer. METHODS: A total of 96 patients in our practice were diagnosed with multiple primary lung cancer over 7 years by clinical-pathologic criteria. According to consolidation/tumor ratio, they were classified into 3 groups: group A (multiple ground-glass opacity-dominant nodules, consolidation/tumor ratio ≤0...
October 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29078629/thoracoscopic-wedge-resection-and-segmentectomy-for-small-sized-pulmonary-nodules
#11
Hirohisa Kato, Hiroyuki Oizumi, Jun Suzuki, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Mitsuaki Sadahiro
With the recent increase in the detection of small-sized lung nodules because of the widespread use of computed tomography (CT), limited resection and minimally invasive surgery are preferred by patients with these lesions. In particular, the detection of nodules that show ground-glass opacity during high-resolution CT has increased. Although lobectomy and lymph node dissection were the standard procedures used for treating lung cancer, limited wedge resection and segmentectomy have become acceptable for treating small-sized lung cancers with nodules showing ground-glass opacity...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29068976/diagnostic-value-of-contrast-enhanced-ct-scans-in-identifying-lung-adenocarcinomas-manifesting-as-ggns-ground-glass-nodules
#12
Feng Gao, Ming Li, Yingli Sun, Li Xiao, Yanqing Hua
This study aimed to explore the value of contrast-enhanced computed tomography (CT) scans in the differential diagnosis of atypical adenomatous hyperplasia, adenocarcinoma in situ, minimal invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC), which manifested as ground glass nodules (GGNs) or mixed GGNs.Unenhanced and contrast-enhanced presurgical CT images of 136 cases of GGNs were compared. The nodules were diagnosed based on their solid portions and maximum dimensions, and the findings obtained using both contrast-enhanced and unenhanced CT images were analyzed in corroboration with the pathological diagnosis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29063257/detection-of-lung-carcinoma-with-predominant-ground-glass-opacity-on-ct-using-temporal-subtraction-method
#13
Takashi Terasawa, Takatoshi Aoki, Seiichi Murakami, Hyoungseop Kim, Masami Fujii, Michiko Kobayashi, Chihiro Chihara, Yoshiko Hayashida, Yukunori Korogi
PURPOSE: To evaluate the usefulness of the CT temporal subtraction (TS) method for the detection of the lung cancer with predominant ground-glass opacity (LC-pGGO). MATERIALS AND METHODS: Twenty-five pairs of CT and their TS images in patients with LC-pGGO (31 lesions) and 25 pairs of those in patients without nodules were used for an observer performance study. Eight radiologists participated and the statistical significance of differences with and without the CT-TS was assessed by JAFROC analysis...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29052576/a-tuberous-sclerosis-family-with-tsc1-c-1030-1g-a-mutation-found-through-a-female-presenting-as-multiple-ground-glass-nodules-in-chest-computed-tomography-incidentally
#14
Ting-Ting Zhao, Yong-Sheng Wang, Yan Li, Miao Ma, Ai-Mei Li, Hou-Rong Cai, Xiang-Shan Fan, Fan-Qing Meng, Li-Yun Miao
No abstract text is available yet for this article.
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29050127/-immune-related-pneumonitis-caused-by-programmed-death-1-inhibitor-pembrolizumab-a-case-report-and-literature-review
#15
Y L Chen, J Zhao, R Jia, H Y Wang, J Zheng, C Q Bai, M Z Wang, J M Xu
Objective: To investigate the risk factors, clinical manifestations, radiological features, diagnosis, treatment and prognosis of immune-related pneumonitis caused by programmed death-1(PD-1)/PD-L1 inhibitors. Methods: The clinical data of immune-related pneumonitis caused by PD-1 inhibitor Pembrolizumab in a patient with advanced esophageal carcinoma admitted to the 307(th) Hospital of Chinese People's Liberation Army was retrospectively analyzed and the related literatures were reviewed. We searched Medline database using the keywords"PD-1 inhibitor","PD-L1 inhibitor","Pembrolizumab","Nivolumab","Atezolizumab"combined with"Pneumonitis"by Mar 31, 2017...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29045176/computer-aided-diagnosis-of-ground-glass-opacity-nodules-using-open-source-software-for-quantifying-tumor-heterogeneity
#16
Ming Li, Vivek Narayan, Ritu R Gill, Jyothi P Jagannathan, Maria F Barile, Feng Gao, Raphael Bueno, Jagadeesan Jayender
OBJECTIVE: The purposes of this study are to develop quantitative imaging biomarkers obtained from high-resolution CTs for classifying ground-glass nodules (GGNs) into atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC); to evaluate the utility of contrast enhancement for differential diagnosis; and to develop and validate a support vector machine (SVM) to predict the GGN type. MATERIALS AND METHODS: The heterogeneity of 248 GGNs was quantified using custom software...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29037300/high-resolution-computed-tomography-findings-in-chronic-eosinophilic-vs-cryptogenic-organising-pneumonia
#17
P Mehrian, A Doroudinia, A Rashti, O Aloosh, A Dorudinia
BACKGROUND: The similar clinical and computed tomography (CT) characteristics of cryptogenic organising pneumonia (COP) and chronic eosinophilic pneumonia (CEP) make precise diagnosis challenging. OBJECTIVES: To help differentiate between COP and CEP using high-resolution CT (HRCT). DESIGN: Clinical data and HRCT images of COP and CEP patients referred to Masih Daneshvari Hospital, Tehran, Iran, from 2007 to 2015 were reviewed. Diagnosis of COP or CEP was confirmed using open lung biopsy or a combination of transbronchial biopsy, bronchoalveolar lavage fluid (BALF) analysis, peripheral eosinophilia and a favourable response to corticosteroids...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29028090/a-comparative-study-on-inflammatory-factors-and-immune-functions-of-lung-cancer-and-pulmonary-ground-glass-attenuation
#18
C-Y Liu, W-G Xie, S Wu, J-W Tian, J Li
OBJECTIVE: To compare the inflammatory factors and immune functions of patients with lung cancer and pulmonary ground-glass attenuation. PATIENTS AND METHODS: A total of 108 patients with pulmonary sarcoidosis treated in our hospital were selected and randomly divided into lung cancer group (Group A, n=32), diffuse ground-glass nodule group (Group B, n=35) and solitary ground-glass nodule group (Group C, n=41) according to the diagnosis results. Levels of inflammatory factors, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10), in serum were detected via enzyme-linked immunosorbent assay (ELISA); the T-lymphocyte subset levels (CD3+, CD4+, CD8+ and CD4+/CD8+) in the immune system of patients in the three groups were detected using the flow cytometer; the levels of immunoglobulins, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM), were detected via immunoturbidimetric assay...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28980178/a-typical-carcinoid-tumor-of-the-lung-presenting-with-pure-persistent-ground-glass-opacity-on-high-resolution-computed-tomography-a-case-report
#19
Masafumi Yamaguchi, Fumihiko Hirai, Kenichi Taguchi, Ryo Toyozawa, Makoto Edagawa, Shinichiro Shimamatsu, Kaname Nosaki, Takashi Seto, Mitsuhiro Takenoyama, Yukito Ichinose
Pure ground-glass opacity nodules (p-GGN) on high-resolution computed tomography (HRCT) generally have been considering typically associated with adenocarcinoma with less invasive nature. We herein reported a patient presenting focal p-GGN on middle lobe of the right lung who underwent surgical resection with its pathological diagnosis turned out to be typical carcinoid tumor.
October 4, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28963659/squamous-cell-carcinoma-of-the-lung-showing-a-ground-glass-nodule-on-high-resolution-computed-tomography-associated-with-pneumoconiosis-a-case-report
#20
Yuriko Terada, Masaaki Sato, Hiroyuki Abe, Hideki Kuwano, Kazuhiro Nagayama, Jun-Ichi Nitadori, Masaki Anraku, Jun Nakajima
BACKGROUND: Adenocarcinoma with lepidic growth pattern presents as a ground glass nodule (GGN) on high resolution computed tomography (CT), whereas peripheral pulmonary squamous cell carcinoma (SCC) usually presents as a solid nodule. We herein report a rare case of pulmonary SCC extending along the alveolar lumen representing as a GGN on a CT scan in a patient with pneumoconiosis. CASE PRESENTATION: A 77-year-old man with pneumoconiosis was found to have a gradually enlarging GGN in the right lower lobe of the lung on CT...
September 29, 2017: Surgical Case Reports
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