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ground glass nodule

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https://www.readbyqxmd.com/read/29791543/rapidly-growing-pulmonary-ground-glass-nodule-caused-by-metastatic-melanoma-lacking-uptake-on-18f-fdg-pet-ct
#1
Giorgia Dalpiaz, Sofia Asioli, Stefano Fanti, Gaetano Rea, Edson Marchiori
No abstract text is available yet for this article.
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29783802/-clinicopathologic-and-molecular-features-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma
#2
X J Cui, H O Zhao, P Su, J Chen, R Y Zhang, Y Pan, X M Ouyang, J Liu, J Q Zhang, Y Yang, R Yang, L Ding, Z Y Liu
Objective: To investigate the clinicopathologic and molecular features of the rare cribriform morular variant of papillary thyroid carcinoma (CMV-PTC). Methods: The clinicopathologic data of 10 patients with CMV-PTC were retrospectively reviewed. Immunohistochemical (IHC) staining was done using LSAB method. DNA sequencing for APC were applied using Sanger method. BRAF V600E mutation was examined using ARMS method. The cytological, morphological, IHC and molecular features were analyzed. Results: All patients were female at an average age of 27 years old...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29782588/ground-glass-pulmonary-nodules-their-significance-in-oncology-patients-and-the-role-of-computer-tomography-and-18f-fluorodeoxyglucose-positron-emission-tomography
#3
Laura Evangelista, Annalori Panunzio, Elena Scagliori, Paolo Sartori
Objective: to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancies and to evaluate the role of computed tomography (CT) and positron emission tomography (PET)/CT in their diagnosis and follow-up. Methods: A total of 130 nodules in 68 patients were revealed: 119 GGNs and 11 MPNs. GGN lesions were found in 58 patients, MPNs in eight, and in two cases, both...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29780626/malignant-solitary-pulmonary-nodules-assessment-of-mass-growth-rate-and-doubling-time-at-follow-up-ct
#4
Jingxu Li, Tingting Xia, Xinguan Yang, Xiao Dong, Jiamin Liang, Nanshan Zhong, Yubao Guan
Background: The differentiation of benign and malignant solitary pulmonary nodules (SPNs), especially subsolid nodules, is still challenging because of the small size, slow growth, and atypical imaging characteristics of these nodules. We aimed to determine the significance of mass growth rate (MGR) and mass doubling time (MDT) at follow-up CT of malignant SPNs. Methods: This retrospective study included 167 patients (169 SPNs, diameter 8-30 mm). Among the 169 SPNs, 114 malignant SPNs were classified into three types: pure ground-glass nodules (pGGNs), part-solid nodules (pSNs), and solid nodules (SNs)...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780625/is-a-5-mm-diameter-an-appropriate-cut-off-value-for-the-diagnosis-of-atypical-adenomatous-hyperplasia-and-adenocarcinoma-in-situ-on-chest-computed-tomography-and-pathological-examination
#5
Xiaohuan Pan, Xinguan Yang, Jingxu Li, Xiao Dong, Jianxing He, Yubao Guan
Background: Preinvasive lesions, such as atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS), usually appear as pure ground-glass nodules (pGGNs) on thin-section computed tomography (TSCT). AAH is usually less than 5 mm wide on imaging and pathological examinations. We aimed to determine whether a 5-mm cut-off value was appropriate for the diagnosis of AAH and AIS. Methods: We retrospectively analyzed the performance of TSCT in evaluating 80 pathologically confirmed preinvasive lesions (33 AAH lesions in 31 patients and 47 AIS lesions in 45 patients)...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29740120/the-clinical-characteristics-and-outcomes-of-follicular-bronchiolitis-in-chinese-adult-patients
#6
Ju Lu, Miao Ma, Qi Zhao, Fanqing Meng, Dongmei Wang, Hourong Cai, Mengshu Cao
Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31-55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736852/thoracic-involvement-in-erdheim-chester-disease-computed-tomography-imaging-findings-and-their-association-with-the-braf-v600e-mutation
#7
S Mojdeh Mirmomen, Arlene Sirajuddin, Moozhan Nikpanah, Rolf Symons, Anna K Paschall, Ioannis Papageorgiou, William A Gahl, Kevin O'Brien, Juvianee I Estrada-Veras, Ashkan A Malayeri
OBJECTIVES: To investigate the computed tomography (CT) thoracic findings in Erdheim-Chester disease (ECD) and evaluate the association of these findings with the BRAFV600E mutation. METHODS: This was a prospective study of patients with ECD (n=61, men=46) who underwent thoracic CT imaging. CT examinations were independently interpreted by two experienced radiologists. Association of imaging findings with BRAFV600E was achieved via the Chi-square or Fisher's exact test and odds ratios (OR) with 95% confidence intervals (CI), as appropriate...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29735498/diffuse-alveolar-haemorrhage-and-libman-sacks-endocarditis-a-rare-presentation-of-antiphospholipid-syndrome
#8
Brianna Bielski, Nikhil H Shah, Donevan Westerveld, Carolyn Stalvey
A 26-year-old woman with a history of idiopathic thrombocytopaenic purpura and a 1-year history of blood-streaked sputum presented after a severe episode of haemoptysis with dyspnoea. Chest imaging revealed diffuse ground glass and bronchovascular nodules. Bronchoscopy revealed bilateral diffuse alveolar haemorrhage (DAH). Sputum and bronchoalveolar lavage studies were negative for infectious aetiologies. A transthoracic echocardiogram revealed Libman-Sacks endocarditis with severe mitral regurgitation and physical examination revealed retinal artery occlusion and Osler's nodes...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29713766/evaluation-of-t-categories-for-pure-ground-glass-nodules-with-semi-automatic-volumetry-is-mass-a-better-predictor-of-invasive-part-size-than-other-volumetric-parameters
#9
Hyungjin Kim, Jin Mo Goo, Chang Min Park
OBJECTIVES: This study aimed to investigate the diagnostic advantage of nodule mass in differentiating invasive pulmonary adenocarcinomas (IPAs) among pure ground-glass nodules (pGGNs) over other volumetric measurements. Another aim of this study was to analyse the correlation between volumetric measurements on computed tomography (CT) scans and the pathological invasive component size. METHODS: This Institutional Review Board-approved retrospective study included 117 patients (men:women = 53:64; mean age, 57...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29701373/uniportal-vats-lobectomy-subxiphoid-approach
#10
Catarina Carvalheiro, Javier Gallego-Poveda, Diego Gonzalez-Rivas, Jorge Cruz
INTRODUCTION: Interest in uniportal video-assisted thoracic surgery (VATS) is rapidly growing worldwide because it represents the surgical approach to the lung with the least possible trauma and in recent years the subxiphoid approach has been used in the field of thoracic surgery as it is associated with lesser pain because there is no intercostal nerve damage and it provides excellent cosmetic outcomes. This technique was recently introduced for major pulmonary resections and even bilateral approaches in selected patients...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29696225/logis-localization-of-ground-glass-opacity-and-pulmonary-lesions-for-minimal-surgery-registry-design-and-rationale
#11
Chul Hwan Park, Dong Jin Im, Sang Min Lee, Ji Won Lee, Sung Ho Hwang, Semin Chong, Min Jae Cha, Kye Ho Lee, Woocheol Kwon, Hwan Seok Yong, Jae Wook Lee, Gong Yong Jin, Sang Hyun Paik, Kyunghwa Han, Jin Hur
Background and purpose: An optimal pulmonary localization technique for video-assisted thoracic surgery (VATS) of small lung nodules has not yet been established. The LOcalization of Ground-glass-opacity and pulmonary lesions for mInimal Surgery (LOGIS) registry aims to establish a multicenter database and investigate the usefulness and safety of localization techniques for small pulmonary lesions in individuals undergoing VATS. Methods/Design: The LOGIS registry is a large-scale, multicenter cohort study, aiming to enroll 825 patients at 10 institutions...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29652577/lung-cancers-associated-with-cystic-airspaces-underrecognized-features-of-early-disease
#12
Sarah Sheard, Joanna Moser, Charlie Sayer, Konstantinos Stefanidis, Anand Devaraj, Ioannis Vlahos
Early lung cancers associated with cystic airspaces are increasingly being recognized as a cause of delayed diagnoses-owing to data gathered from screening trials and encounters in routine clinical practice as more patients undergo serial imaging. Several morphologic subtypes of cancers associated with cystic airspaces exist and can exhibit variable patterns of progression as the solid elements of the tumor grow. Current understanding of the pathogenesis of these malignancies is limited, and the numbers of cases reported in the literature are small...
April 13, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29651817/two-cases-of-chloromethylisothiazolinone-and-methylisothiazolinone-associated-toxic-lung-injury
#13
Eun Lee, Seung Kook Son, Jisun Yoon, Hyun Ju Cho, Song I Yang, Sungsu Jung, Kyung Hyun Do, Young Ah Cho, So Yeon Lee, Dong Uk Park, Soo Jong Hong
Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH)...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29600078/predicting-malignancy-of-pulmonary-ground-glass-nodules-and-their-invasiveness-by-random-forest
#14
Xueyan Mei, Rui Wang, Wenjia Yang, Fangfei Qian, Xiaodan Ye, Li Zhu, Qunhui Chen, Baohui Han, Timothy Deyer, Jingyi Zeng, Xiaomeng Dong, Wen Gao, Wentao Fang
Background: The purpose of this study was to develop a predictive model that could accurately predict the malignancy of the pulmonary ground-glass nodules (GGNs) and the invasiveness of the malignant GGNs. Methods: The authors built two binary classification models that could predict the malignancy of the pulmonary GGNs and the invasiveness of the malignant GGNs. Results: Results of our developed model showed random forest could achieve 95...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29600072/aberrant-status-and-clinicopathologic-characteristic-associations-of-11-target-genes-in-1-321-chinese-patients-with-lung-adenocarcinoma
#15
Mengnan Zhao, Cheng Zhan, Ming Li, Xiaodong Yang, Xinyu Yang, Yong Zhang, Miao Lin, Yifeng Xia, Mingxiang Feng, Qun Wang
Background: The aberrant status of target genes and their associations with clinicopathologic characteristics are still unclear in primary lung adenocarcinoma. Methods: The common mutations and translocations of nine target genes were evaluated in 1,247 specimens of surgically-resected primary lung adenocarcinoma. Immunohistochemistry was used to analyze the expressions of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) in 731 specimens. The frequency of the aberrations and their associations with clinicopathologic characteristics were analyzed...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29587931/-management-strategies-of-pulmonary-ground-galss-nodule
#16
Qun Wang
Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. The management for pulmonary GGN remains controversial. Both Fleischner society and National Comprehensive Cancer Network (NCCN) panel updated the guideline for the management of GGN in 2017. Compared with previous versions, the indication for surgery or biopsy is stricter, and the recommended follow-up interval is prolonged. In clinical practice, the size of GGN component, the size of consolidation component, dynamic change during follow-up and computed tomography (CT) value are the four factors that help surgeons to decide the timing of surgery...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29587930/-shanghai-pulmonary-hospital-experts-consensus-on-the-management-of-ground-glass-nodules-suspected-as-lung-adenocarcinoma-version-1
#17
Gening Jiang, Chang Chen, Yuming Zhu, Dong Xie, Jie Dai, Kaiqi Jin, Yingran Shen, Haifeng Wang, Hui Li, Lanjun Zhang, Shugeng Gao, Keneng Chen, Lei Zhang, Xiao Zhou, Jingyun Shi, Hao Wang, Boxiong Xie, Lei Jiang, Jiang Fan, Deping Zhao, Qiankun Chen, Liang Duan, Wenxin He, Yiming Zhou, Hongcheng Liu, Xiaogang Zhao, Peng Zhang, Xiong Qin
Background and objective As computed tomography (CT) screening for lung cancer becomes more common in China, so too does detection of pulmonary ground-glass nodules (GGNs). Although anumber of national or international guidelines about pulmonary GGNs have been published,most of these guidelines are produced by respiratory, oncology or radiology physicians, who might not fully understand the progress of modern minimal invasive thoracic surgery, and these current guidelines may overlook or underestimate the value of thoracic surgery in the management of pulmonary GGNs...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29577613/molecular-biological-analysis-in-a-patient-with-multiple-lung-adenocarcinomas
#18
Tomoshige Wakayama, Hirokuni Hirata, Shunsuke Suka, Kozo Sato, Masamitsu Tatewaki, Ryosuke Souma, Hideyuki Satoh, Motohiko Tamura, Yuji Matsumura, Hiroki Imada, Kumiya Sugiyama, Masafumi Arima, Kazuhiro Kurasawa, Takeshi Fukuda, Yasutsugu Fukushima
The utility of molecular biological analysis in lung adenocarcinoma has been demonstrated. Herein we report a rare case presenting as multiple lung adenocarcinomas with four different EGFR gene mutations detected in three lung tumors. After opacification was detected by routine chest X-ray, the patient, a 64-year-old woman, underwent chest computed tomography which revealed a right lung segment S4 ground-glass nodule (GGN). Follow-up computed tomography revealed a 42 mm GGN nodule with a 26 mm nodule (S6) and a 20 mm GGN (S10)...
March 26, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29572008/what-ct-characteristics-of-lepidic-predominant-pattern-lung-adenocarcinomas-correlate-with-invasiveness-on-pathology
#19
Emily A Aherne, Andrew J Plodkowski, Joseph Montecalvo, Sumar Hayan, Junting Zheng, Marinela Capanu, Prasad S Adusumilli, William D Travis, Michelle S Ginsberg
OBJECTIVES: The International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society lung adenocarcinoma classification in 2011 defined three lepidic predominant patterns including adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma. We sought to correlate the radiology and pathology findings and identify any computed tomography (CT) features which can be associated with invasive growth. MATERIALS AND METHODS: An institutional review board approved, retrospective study was conducted evaluating 63 patients with resected, pathologically confirmed, adenocarcinomas with predominant lepidic patterns...
April 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29530486/qualitative-ct-criterion-for-subsolid-nodule-subclassification-improving-interobserver-agreement-and-pathologic-correlation-in-the-adenocarcinoma-spectrum
#20
Po An Chen, Eric P Huang, Lu Yang Shih, En Kuei Tang, Chu Chun Chien, Ming Ting Wu, Fu Zong Wu
RATIONALE AND OBJECTIVES: The main aim of this study was to evaluate the clinical validity and correlation with pathologic invasiveness in the pulmonary adenocarcinoma spectrum based on the novel qualitative computed tomography criterion for subsolid nodule (SSN) classification, which classified SSN into pure ground-glass nodule, heterogeneous ground-glass nodule, and part-solid nodule. In addition, we compared the performance of the conventional and novel classifications. MATERIALS AND METHODS: The computed tomography images of 41 SSN nodules were interpreted by six observers independently, and the SSN characteristics were classified according to both the conventional and the novel classification systems...
March 9, 2018: Academic Radiology
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