keyword
MENU ▼
Read by QxMD icon Read
search

cognitive reserve

keyword
https://www.readbyqxmd.com/read/29776014/association-of-objectively-measured-physical-activity-with-brain-structure-uk-biobank-study
#1
Mark Hamer, Nikhil Sharma, G David Batty
BACKGROUND: Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region. METHODS: We used data from UK Biobank (n=5,272; aged 55.4±7.5 yrs; 45.6% men) collected through 2013-2016. Participants wore the Axivity AX3 wrist-worn triaxial accelerometer for seven days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain...
May 18, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29776004/knowledge-and-health-beliefs-about-gestational-diabetes-and-healthy-pregnancy-s-breastfeeding-intention
#2
Seungmi Park, Jung Lim Lee, Jang In Sun, Youngji Kim
AIMS AND OBJECTIVES: If the knowledge and health beliefs relating to gestational diabetes mellitus (GDM) during pregnancy are associated with behaviours during pregnancy and lactation, this suggests potential educational interventions. BACKGROUNDS: Women with GDM are more likely to develop type 2 diabetes mellitus (T2DM), and babies with GDM incur increased risk of neonatal hypoglycaemia and childhood obesity. Breastfeeding is an effective way to improve maternal and lipid metabolism of gestational diabetes mothers, and to lower the risk of T2DM after birth, to prevent conception...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29776002/the-chaos-of-hospitalisation-for-patients-with-critical-limb-ischaemia-approaching-major-amputation
#3
Susan Monaro, Sandra West, Jana Pinkova, Janice Gullick
AIMS AND OBJECTIVES: To illuminate the hospital experience for patients and families when major amputation has been advised for critical limb ischaemia (CLI). BACKGROUND: CLI creates significant burden to the health system and the family, particularly as the person with CLI approaches amputation. Major amputation is often offered as a late intervention for CLI in response to the marked deterioration of an ischaemic limb, and functional decline from reduced mobility, intractable pain, infection and/or toxaemia...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29772378/a-task-invariant-cognitive-reserve-network
#4
Yaakov Stern, Yunglin Gazes, Qolomreza Razlighi, Jason Steffener, Christian Habeck
The concept of cognitive reserve (CR) can explain individual differences in susceptibility to cognitive or functional impairment in the presence of age or disease-related brain changes. Epidemiologic evidence indicates that CR helps maintain performance in the face of pathology across multiple cognitive domains. We therefore tried to identify a single, "task-invariant" CR network that is active during the performance of many disparate tasks. In imaging data acquired from 255 individuals age 20-80 while performing 12 different cognitive tasks, we used an iterative approach to derive a multivariate network that was expressed during the performance of all tasks, and whose degree of expression correlated with IQ, a proxy for CR...
May 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29772106/the-relationships-between-pain-catastrophizing-subcomponents-and-multiple-pain-related-outcomes-in-japanese-outpatients-with-chronic-pain-a-cross-sectional-study
#5
Tomonori Adachi, Aya Nakae, Tomoyuki Maruo, Kenrin Shi, Lynn Maeda, Youichi Saitoh, Masahiko Shibata, Jun Sasaki
OBJECTIVES: The present study sought to examine associations between the pain catastrophizing subcomponents and multiple pain-related outcomes in Japanese individuals with chronic pain. METHODS: A cross-sectional study design was employed with 213 chronic pain outpatients. The participants were recruited from three units at one university hospital and from a pain clinic at a municipal hospital. Study measures were used to assess pain catastrophizing, anxiety, depression, pain interference, and pain severity...
May 17, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29768649/selection-for-associative-learning-of-colour-stimuli-reveals-correlated-evolution-of-this-learning-ability-across-multiple-stimuli-and-rewards
#6
Maartje Liefting, Katja M Hoedjes, Cécile Le Lann, Hans M Smid, Jacintha Ellers
We are only starting to understand how variation in cognitive ability can result from local adaptations to environmental conditions. A major question in this regard is to what extent selection on cognitive ability in a specific context affects that ability in general through correlated evolution. To address this question we performed artificial selection on visual associative learning in female Nasonia vitripennis wasps. Using appetitive conditioning in which a visual stimulus was offered in association with a host reward, the ability to learn visual associations was enhanced within 10 generations of selection...
May 16, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29757481/severe-white-matter-astrocytopathy-in-cadasil
#7
Yoshiki Hase, Aiqing Chen, Letitia L Bates, Lucinda J L Craggs, Yumi Yamamoto, Elizabeth Gemmell, Arthur E Oakley, Viktor I Korolchuk, Raj N Kalaria
Objectives Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterised by strategic white matter (WM) hyperintensities on MRI. Pathological features include WM degeneration, arteriolosclerosis, lacunar infarcts and the deposition of granular osmiophilic material. Based on the hypothesis that the gliovascular unit is compromised, we assessed the nature of astrocyte damage in the deep WM of CADASIL subjects. Methods We evaluated post-mortem brains from CADASIL, cerebral small vessel disease, similar age cognitively normal and older control subjects...
May 14, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29756163/diagnostic-utility-of-18f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-in-asymptomatic-subjects-at-increased-risk-for-alzheimer-s-disease
#8
REVIEW
Alexander Drzezga, Daniele Altomare, Cristina Festari, Javier Arbizu, Stefania Orini, Karl Herholz, Peter Nestor, Federica Agosta, Femke Bouwman, Flavio Nobili, Zuzana Walker, Giovanni Battista Frisoni, Marina Boccardi
PURPOSE: To assess the clinical utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of early signs of neurodegeneration in conditions of increased risk for Alzheimer's disease (AD) as defined by: subjective cognitive decline (SCD), evidence of cerebral amyloid-pathology, apolipoprotein E (APOE) ε4-positive genotype, or autosomal dominant forms of AD (ADAD) in asymptomatic stages. METHODS: A comprehensive literature search was conducted using the PICO model to extract evidence from relevant studies...
May 13, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29754428/tapering-off-long-term-opioid-therapy-in-chronic-non-cancer-pain-patients-a-randomized-clinical-trial
#9
Geana Paula Kurita, Jette Højsted, Per Sjøgren
BACKGROUND: The indications for initiating long-term opioid treatment (L-TOT) for chronic non-cancer pain (CNCP) are often unclear and associated with problematic use. This study aimed at evaluating the efficacy of stabilizing opioid therapy followed by a sequential opioid tapering off program in CNCP patients. METHODS: A randomized clinical trial with a medications stabilization period (Phase 1) followed by a opioid tapering off program (Phase 2). In Phase 2, patients were randomized to Control Group (stable treatment) or Taper off Group (sequential opioid dose reduction) and assessed at baseline, after stabilization and up to six months...
May 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29754390/the-importance-of-contextual-relational-and-cognitive-factors-for-novice-nurses-emotional-state-and-affective-commitment-to-the-profession-a-multilevel-study
#10
Yvonne Ten Hoeve, Jasperina Brouwer, Petrie F Roodbol, Saskia Kunnen
AIM: This study explored the effects of contextual, relational and cognitive factors derived from novice nurses' work experiences on emotions and affective commitment to the profession. BACKGROUND: With an increasing demand for well-trained nurses, it is imperative to investigate which work-related factors most affect their commitment to develop effective strategies to improve work conditions, work satisfaction and emotional attachment. DESIGN: A repeated-measures within subjects design...
May 13, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29751371/status-epilepticus-associated-with-acute-encephalitis-long-term-follow-up-of-functional-and-cognitive-outcomes-in-72-patients
#11
Weibi Chen, Yingying Su, Mengdi Jiang, Gang Liu, Fei Tian, Guoping Ren
BACKGROUND: Continued care in patients with encephalitis and prolonged status epilepticus (SE) is controversial. Limited data is available on the functional and cognitive outcomes. METHODS: In a prospective cohort study from 2007 to 2016, patients with acute encephalitis and SE were reviewed. Long-term outcomes including motor disability (modified Rankin Scale, mRS), daily living skills (activities of daily living, ADL), cognitive ability (modified Telephone Interview for Cognitive Status, TICS-M) and epilepsy sequelae, were evaluated in those survivors at 12-month follow-up...
May 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29750386/saliva-in-the-omics-era-a-promising-tool-in-paediatrics
#12
Eftychia Pappa, Eleni Kousvelari, Heleni Vastardis
In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its non-invasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29750367/efficacy-of-maternal-choline-supplementation-during-pregnancy-in-mitigating-adverse-effects-of-prenatal-alcohol-exposure-on-growth-and-cognitive-function-a-randomized-double-blind-placebo-controlled-clinical-trial
#13
Sandra W Jacobson, R Colin Carter, Christopher D Molteno, Mark E Stanton, Jane Herbert, Nadine M Lindinger, Catherine E Lewis, Neil C Dodge, H Eugene Hoyme, Steven H Zeisel, Ernesta M Meintjes, Christopher P Duggan, Joseph L Jacobson
BACKGROUND: We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy. In this paper, we report our results relating to the efficacy of this intervention in mitigating adverse effects of prenatal alcohol exposure on infant growth and cognitive function. METHODS: 69 Cape Coloured (mixed ancestry) heavy drinkers in Cape Town, South Africa, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of either 2 g of choline or placebo from time of enrollment until delivery...
May 11, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29747244/nucleus-reuniens-of-the-thalamus-controls-fear-memory-intensity-specificity-and-long-term-maintenance-during-consolidation
#14
Fernanda Troyner, Maira A Bicca, Leandro J Bertoglio
The thalamic nucleus reuniens (NR) has been shown to support bidirectional medial prefrontal cortex-hippocampus communication and synchronization relevant for cognitive processing. Using non-selective or prolonged inactivation of the NR, previous studies reported its activity positively modulates aversive memory consolidation. Here we examined the NR's role in consolidating contextual fear memories with varied strength, at both recent and more remote time points, using muscimol-induced temporary inactivation in rats...
May 10, 2018: Hippocampus
https://www.readbyqxmd.com/read/29742814/optogenetic-stimulation-understanding-memory-and-treating-deficits
#15
S C Barnett, B A L Perry, J C Dalrymple-Alford, L C Parr-Brownlie
Technology allowing genetically targeted cells to be modulated by light has revolutionised neuroscience in the past decade, and given rise to the field of optogenetic stimulation. For this, non-native, light activated proteins (e.g. channelrhodopsin) are expressed in a specific cell phenotype (e.g. glutamatergic neurons) in a subset of central nervous system nuclei, and short pulses of light of a narrow wavelength (e.g. blue, 473 nm) are used to modulate cell activity. Cell activity can be increased or decreased depending on which light activated protein is used...
May 9, 2018: Hippocampus
https://www.readbyqxmd.com/read/29741714/variety-of-enriching-early-life-activities-linked-to-late-life-cognitive-functioning-in-urban-community-dwelling-african-americans
#16
Thomas Chan, Jeanine M Parisi, Kyle D Moored, Michelle C Carlson
Objectives: The early environment is thought to be a critical period in understanding the cognitive health disparities African Americans face today. Much is known about the positive role enriching environments have in mid- and late-life and the negative function adverse experiences have in childhood; however, little is known about the relationship between enriching childhood experiences and late life cognition. The current study examines the link between variety of enriching early life activities with late life cognitive functioning in a sample of sociodemographic at-risk older adults...
May 7, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29740871/the-neuropeptide-12-n-pep-12-improves-recognition-memory-and-neuronal-plasticity-of-the-limbic-system-in-old-rats
#17
Elizabeth Monserrat Hernández-Hernández, Karen Caporal Hernandez, Rubén Antonio Vázquez-Roque, Alfonso Díaz, Fidel de la Cruz, Benjamin Florán, Gonzalo Flores
Aging is a stage of life where cognitive and motor functions are impaired. This is because oxidative and inflammatory processes exacerbate neurodegeneration, which affects dendritic morphology and neuronal communication of limbic regions with memory loss. Recently, the use of trophic substances has been proposed to prevent neuronal deterioration. The neuropeptide-12 (N-PEP-12) has been evaluated in elderly patients with dementia, showing improvements in cognitive tasks due to acts as a neurotrophic factor. In the present work, we evaluated the effect of N-PEP-12 on motor activity and recognition memory, as well as its effects on dendritic morphology and the immunoreactivity of GFAP, Synaptophysin, and BDNF in neurons of the prefrontal cortex (PFC), dorsal hippocampus (DH) and nucleus accumbens (NAcc) of aged rats...
May 8, 2018: Synapse
https://www.readbyqxmd.com/read/29739655/identifying-research-priorities-around-psycho-cognitive-and-social-factors-for-recovery-from-hip-fractures-an-international-decision-making-process
#18
Mohammad Auais, Simon D French, Lauren Beaupre, Lora Giangregorio, Jay Magaziner
Hip fractures rank in the top ten disabling conditions worldwide. With an ageing population, this public health problem is expected to increase. Despite the success of surgery for hip fractures and the extensive health services utilisation, health outcomes are often poor. Considering the recovery process as multifactorial and intervening to address all relevant factors may improve recovery rates. However, we need first to fully understand the factors contributing to recovery after hip fractures, including psycho-cognitive and social factors...
April 20, 2018: Injury
https://www.readbyqxmd.com/read/29738102/validation-of-the-brief-confusion-assessment-method-for-screening-delirium-in-elderly-medical-patients-in-a-german-emergency-department
#19
Verena Baten, Hans-Jörg Busch, Caroline Busche, Bonaventura Schmid, Miriam Heupel-Reuter, Evgeniy Perlov, Jochen Brich, Stefan Klöppel
BACKGROUND: Delirium is frequent in elderly patients presenting in the emergency department (ED). Despite the severe prognosis, the majority of delirium cases remain undetected by emergency physicians (EPs). At the time of our study there was no valid delirium screening tool available for EDs in German-speaking regions. We aimed to evaluate the brief Confusion Assessment Method (bCAM) for a German ED during the daily work routine. METHODS: We implemented the bCAM into practice in a German interdisciplinary high volume ED, and evaluated the bCAM's validity in a convenience sample of medical patients aged ≥70 years...
May 8, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29736913/effects-of-caffeine-on-behavioural-and-cognitive-deficits-in-rats
#20
Melissa S Assis, Aluízio C Soares, Dircilei N de Sousa, João Eudes-Filho, Lilian Rosana F Faro, Fabiana P Carneiro, Mônica V da Silva, Andrea B Motoyama, Greice Maria R de Souza, Stéphanie Marchiori, Nadyelle T de Lima, Raphael Boëchat-Barros, Vania M Ferreira
There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the cecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity...
May 7, 2018: Basic & Clinical Pharmacology & Toxicology
keyword
keyword
38613
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"