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Hydrogen sulphide

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https://www.readbyqxmd.com/read/28433660/redox-regulation-of-gasotransmission-in-the-vascular-system-a-focus-on-angiogenesis
#1
REVIEW
Rajesh K Mistry, Alison C Brewer
Reactive oxygen species have emerged as key participants in a broad range of physiological and pathophysiological processes, not least within the vascular system. Diverse cellular functions which have been attributed to some of these pro-oxidants within the vasculature include the regulation of blood pressure, neovascularisation and vascular inflammation. We here highlight the emerging roles of the enzymatically-generated reaction oxygen species, O2(-) and H2O2, in the regulation of the functions of the gaseous signalling molecules: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H2S)...
April 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28423592/protective-effect-of-hydrogen-sulphide-against-myocardial-hypertrophy-in-mice
#2
Mingjing Shao, Chuanjun Zhuo, Ronghuan Jiang, Guangdong Chen, Jianmin Shan, Jing Ping, Hongjun Tian, Lina Wang, Chongguang Lin, Lirong Hu
Cardiac hypertrophy is a critical component of phenotype in the failing heart. Recently, increasing evidence has demonstrated that oxidative stress plays an important role in the pathogenesis of myocardial hypertrophy. In the present study, we generated a mouse model of transverse aortic constriction (TAC) to investigate whether hydrogen sulfide (H2S) has protective effects against cardiac hypertrophy. Left ventricular structure was analyzed by two-dimensional echocardiography. Oxidative stress was evaluated by measuring malondialdehyde, superoxide dismutase, glutathione peroxidase and reactive oxygen specie in the myocardium...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387464/a-novel-ph-controlled-hydrogen-sulfide-donor-protects-gastric-mucosa-from-aspirin-induced-injury
#3
Chun-Tao Yang, Zhen-Zhen Lai, Ze-Hang Zheng, Jian-Ming Kang, Ming Xian, Rui-Yu Wang, Kun Shi, Fu-Hui Meng, Xiang Li, Li Chen, Hui Zhang
Hydrogen sulphide (H2 S) serves as a vital gastric mucosal defence under acid condition. Non-steroidal anti-inflammatory drugs (NSAIDs) are among widely prescribed medications with effects of antipyresis, analgesia and anti-inflammation. However, their inappropriate use causes gastric lesions and endogenous H2 S deficiency. In this work, we reported the roles of a novel pH-controlled H2 S donor (JK-1) in NSAID-related gastric lesions. We found that JK-1 could release H2 S under mild acidic pH and increase solution pH value...
April 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28383289/effect-of-the-amount-of-nickel-sulphide-molybdenum-disulphide-and-carbon-nanosupport-towards-tafel-slope-and-overpotential-optimization
#4
Maria Sarno, Eleonora Ponticorvo
A Tafel slope of 40 mV/dec and a very small overpotential were measured for our NiSMoS2G nanocatalyst prepared by a scalable approach and consisting of: NiS nanoparticles covered by a stabilizing coating of MoS2 nanosheets on unsophisticated and easy to be obtained physical exfoliated graphite (PHG). A careful study proves that it is possible to improve the Tafel Slope and the overpotential through the optimization of the amounts of the different components. The conductive nanocarbons network, the highly active to charge accumulation NiS nanoparticles and the coupling with MoS2 nanosheets exposing a large number of edges, result in a very high hydrogen production rate of 1...
April 6, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28366002/side-by-side-comparison-of-hydroperoxide-and-corresponding-alcohol-as-hydrogen-bond-donors
#5
Kristian H Møller, Camilla Mia Tram, Henrik G Kjaergaard
Hydroperoxides are formed in significant amounts in the atmosphere by oxidation of volatile organic compounds and are key in aerosol formation. In a room-temperature experiment, we detected the formation of bimolecular complexes of tert-butyl hydroperoxide (t-BuOOH) and the corresponding alcohol tert-butanol (t-BuOH), with dimethyl ether (DME) as the hydrogen-bond acceptor. Using a combination of Fourier-transform infrared spectroscopy and quantum chemical calculations, we compare the strength of the OH-O hydrogen bond and the total strength of complexation...
April 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28346391/hydrogen-sulphide-production-in-healthy-and-ulcerated-gastric-mucosa-of-rats
#6
Patrycja Bronowicka-Adamska, Maria Wróbel, Marcin Magierowski, Katarzyna Magierowska, Sławomir Kwiecień, Tomasz Brzozowski
Hydrogen sulphide (H₂S) is produced endogenously via two enzymes dependent on pyridoxal phosphate (PLP): cystathionine beta-synthase (CBS, EC 4.2.1.22), cystathionase γ-liase (CTH, EC 4.4.1.1), and a third, 3-mercaptopyruvate sulfurtransferase (MPST, EC 2.8.1.2). H₂S strengthens the defence mechanisms of the gastric mucosal barrier, and plays an important role in gastroprotection, including the increased resistance to damage caused by various irritants and non-steroidal anti-inflammatory drugs. The study was conducted to determine the role of H₂S in ulcerated gastric mucosa of rats caused by immobilization in cold water (WRS)...
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28251989/silver-nanoparticles-reduce-brain-inflammation-and-related-neurotoxicity-through-induction-of-h2s-synthesizing-enzymes
#7
Daniel A Gonzalez-Carter, Bey Fen Leo, Pakatip Ruenraroengsak, Shu Chen, Angela E Goode, Ioannis G Theodorou, Kian Fan Chung, Raffaella Carzaniga, Milo S P Shaffer, David T Dexter, Mary P Ryan, Alexandra E Porter
Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Given microglia are implicated in neurodegenerative disorders such as Parkinson's disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess AgNP neurotoxicity. In addition, understanding AgNP processing by microglia will allow better prediction of their long term bioreactivity...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28244881/oral-or-nasal-breathing-real-time-effects-of-switching-sampling-route-onto-exhaled-voc-concentrations
#8
Pritam Sukul, Peter Oertel, Svend Kamysek, Phillip Trefz
There is a need for standardisation in sampling and analysis of breath volatile organic compounds (VOCs) in order to minimise ubiquitous confounding effects. Physiological factors may mask concentration changes induced by pathophysiological effects. In humans, unconscious switching of oral and nasal breathing can occur during breath sampling, which may affect VOC patterns. Here, we investigated exhaled VOC concentrations in real-time while switching breathing routes. Breath from 15 healthy volunteers was analysed continuously by proton transfer reaction time-of-flight mass spectrometry during paced breathing (12 breaths min(-1))...
March 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28185540/medicinal-chemistry-approaches-of-controlling-gastrointestinal-side-effects-of-non-steroidal-anti-inflammatory-drugs-endogenous-protective-mechanisms-and-drug-design
#9
Paraskevi Tziona, Panagiotis Theodosis-Nobelos, Eleni A Rekka
BACKGROUND: Non steroidal anti-inflammatory drugs are of the oldest and most widely used medicines. However, their untoward effects, especially gastrointestinal toxicity, remain the main obstacle to their application. Because of their mechanism of action, cycloxygenase (COX) inhibition, in combination with the weekly acidic character of most of them, major protective mechanisms of the gastrointestinal system are suppressed and deregulated. OBJECTIVE: In this review, several compounds designed to retain anti-inflammatory activity, but devoid of gastrointestinal side effects, are presented...
February 9, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28150299/role-of-pvat-in-coronary-atherosclerosis-and-vein-graft-patency-friend-or-foe
#10
REVIEW
M S Fernández-Alfonso, M Gil-Ortega, I Aranguez, D Souza, M Dreifaldt, B Somoza, M R Dashwood
Perivascular adipose tissue (PVAT) releases numerous factors and adipokines with paracrine effects on both vascular structure and function. These effects are variable as they depend on regional differences in PVAT among blood vessels and vary with changes in adiposity. There is considerable evidence demonstrating an association between coronary PVAT and the development and progression of coronary artery disease, which is associated with inflammation, oxidative stress, angiogenesis, vascular remodelling and blood clotting...
February 1, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28070795/td-dft-study-of-absorption-and-emission-spectra-of-2-2-aminophenyl-benzothiazole-derivatives-in-water
#11
Natthaporn Manojai, Rathawat Daengngern, Khanittha Kerdpol, Nawee Kungwan, Chanisorn Ngaojampa
Reduction of aromatic azides to amines is an important property of hydrogen sulphide (H2S) which is useful in fluorescence microscopy and H2S probing in cells. The aim of this work is to study the substituent effect on the absorption and emission spectra of 2-(2'-aminophenyl)benzothiazole (APBT) in order to design APBT derivatives for the use of H2S detection. Absorption and emission spectra of APBT derivatives in aqueous environment were calculated using density functional theory (DFT) and time-dependent DFT (TD-DFT) at B3LYP/6-311+G(d,p) level...
January 9, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/27983540/plasma-nitric-oxide-level-is-correlated-with-microvascular-functions-in-the-peripheral-arterial-disease
#12
Muzaffer Akkoca, Suzan Emel Usanmaz, Cuneyt Koksoy, Ugur Bengisun, Emine Demirel-Yilmaz
At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising a control group of healthy individuals, and patients with PAD caused by either atherosclerosis or Buerger's disease. Microvascular perfusion was examined using laser Doppler imaging of cutaneous erythrocyte flux after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP)...
2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27929450/disposable-paper-based-inkjet-printed-humidity-and-h%C3%A2-s-gas-sensor-for-passive-sensing-applications
#13
Abdul Quddious, Shuai Yang, Munawar M Khan, Farooq A Tahir, Atif Shamim, Khaled N Salama, Hammad M Cheema
An inkjet-printed, fully passive sensor capable of either humidity or gas sensing is presented herein. The sensor is composed of an interdigitated electrode, a customized printable gas sensitive ink and a specialized dipole antenna for wireless sensing. The interdigitated electrode printed on a paper substrate provides the base conductivity that varies during the sensing process. Aided by the porous nature of the substrate, a change in relative humidity from 18% to 88% decreases the electrode resistance from a few Mega-ohms to the kilo-ohm range...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27910968/designing-hierarchical-hollow-nanostructures-of-cu2mos4-for-improved-hydrogen-evolution-reaction
#14
Ke Zhang, Yongli Zheng, Yunxiang Lin, Changda Wang, Hengjie Liu, Daobin Liu, Chuanqiang Wu, Shuangming Chen, Yanxia Chen, Li Song
Layered Cu2MoS4, consisting of earth-abundant elements, is regarded as a potential catalyst for the hydrogen evolution reaction (HER). Herein, we demonstrate a Cu2O-based template strategy to synthesise hierarchical hollow nanostructures of Cu2MoS4. The characterizations reveal that the electrochemically active surface of the hollow Cu2MoS4 is largely enhanced, in contrast to the nanosheet or nanoparticle structures. As the direct outcome, the designed hierarchical hollow structures display excellent HER activities with a low overvoltage and small Tafel slope...
December 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27873232/evidence-based-revised-view-of-the-pathophysiology-of-preeclampsia
#15
Asif Ahmed, Homira Rezai, Sophie Broadway-Stringer
Preeclampsia is a life-threatening vascular disorder of pregnancy due to a failing stressed placenta. Millions of women risk death to give birth each year and globally each year, almost 300,000 lose their life in this process and over 500,000 babies die as a consequence of preeclampsia. Despite decades of research, we lack pharmacological agents to treat it. Maternal endothelial oxidative stress is a central phenomenon responsible for the preeclampsia phenotype of high maternal blood pressure and proteinuria...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27796938/plasma-hydrogen-sulphide-does-not-predict-severity-of-acute-pancreatitis-in-humans
#16
Iqbal N Qureshi, Deepu David, Kavitha R Thangaraj, Reuben T Kurien, Sudipta D Chowdhury, Ashish Goel, Amit K Dutta, Ebby G Simon, Anup Ramachandran, Kunissery A Balasubramanian, Anjilivelil J Joseph
The primary aim of this study was to assess the usefulness of plasma hydrogen sulphide (H2S) level at admission as a predictor of severity of acute pancreatitis. The secondary aims were to examine whether the level of H2S after 48 h correlated with severity and whether level of H2S correlated with pulmonary, renal or infectious complications. Plasma hydrogen sulphide was measured within 24 h of admission and 48 h later, in patients with acute pancreatitis. Patients were classified as having mild or severe pancreatitis, and H2S levels in the two groups were compared...
November 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27779471/the-adaptive-role-of-nitric-oxide-and-hydrogen-sulphide-in-vasoactive-responses-of-thoracic-aorta-is-triggered-already-in-young-spontaneously-hypertensive-rats
#17
S Cacanyiova, A Berenyiova, F Kristek, M Drobna, K Ondrias, M Grman
The aorta plays an important role in blood pressure control so the early determination of its vasoactive properties could predict pathological changes in hypertension. The aim of study was to compare vasoactive properties and geometry of thoracic aorta (TA) and the participation of two vasoactive transmitters, nitric oxide (NO) and hydrogen sulphide (H2S), in TA tone regulation in young Wistar rats (WR) and spontaneously hypertensive rats (SHR). Four-weeks-old WR and SHR were used. Systolic blood pressure (sBP) was measured by plethysmography...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27775418/cardiovascular-effects-of-gasotransmitter-donors
#18
REVIEW
M Cebová, M Košútová, O Pecháňová
Gasotransmitters represent a subfamily of the endogenous gaseous signaling molecules that include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H(2)S). These particular gases share many common features in their production and function, but they fulfill their physiological tasks in unique ways that differ from those of classical signaling molecules found in tissues and organs. These gasotransmitters may antagonize or potentiate each other's cellular effects at the level of their production, their downstream molecular targets and their direct interactions...
October 24, 2016: Physiological Research
https://www.readbyqxmd.com/read/27775417/the-role-of-hydrogen-sulphide-in-blood-pressure-regulation
#19
REVIEW
S Cacanyiova, A Berenyiova, F Kristek
Cardiovascular studies have confirmed that hydrogen sulphide (H(2)S) is involved in various signaling pathways in both physiological and pathological conditions, including hypertension. In contrast to nitric oxide (NO), which has a clear vasorelaxant action, H(2)S has both vasorelaxing and vasoconstricting effects on the cardiovascular system. H(2)S is an important antihypertensive agent, and the reduced production of H(2)S and the alterations in its functions are involved in the initiation of spontaneous hypertension...
October 24, 2016: Physiological Research
https://www.readbyqxmd.com/read/27704382/cleaner-processing-a-sulphide-free-approach-for-depilation-of-skins
#20
Ammasi Ranjithkumar, Jayanthi Durga, Ramakrishnan Ramesh, Chellan Rose, Chellappa Muralidharan
The conventional unhairing process in leather making utilises large amount of lime and sodium sulphide which is hazardous and poses serious waste disposal concerns. Under acidic conditions, sodium sulphide liberates significant quantities of hydrogen sulphide which causes frequent fatal accidents. Further, the conventional unhairing process involves destruction of the hair leading to increased levels of biological oxygen demand (BOD), chemical oxygen demand (COD), total dissolved solids (TDS) and total suspended solids (TSS) in the effluent...
January 2017: Environmental Science and Pollution Research International
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