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Severe skin and soft tissue infections

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https://www.readbyqxmd.com/read/29089730/clinical-presentation-of-soft-tissue-infections-and-its-management-a-study-of-100-cases
#1
Baldev Singh, Sukha Singh, Sudhir Khichy, Avinash Ghatge
BACKGROUND: Soft-tissue infections vary widely in their nature and severity. A clear approach to the management must allow their rapid identification and treatment as they can be life-threatening. OBJECTIVE: Clinical presentation of soft-tissue infections and its management. MATERIALS AND METHODS: A prospective study based on 100 patients presenting with soft-tissue infections was done. All the cases of soft-tissue infections were considered irrespective of age, sex, etiological factors, or systemic disorders...
July 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29082520/necrotizing-soft-tissue-infections-a-multicentre-prospective-observational-study-infect-protocol-and-statistical-analysis-plan
#2
M B Madsen, S Skrede, T Bruun, P Arnell, A Rosén, M Nekludov, Y Karlsson, F Bergey, E Saccenti, V A P Martins Dos Santos, A Perner, A Norrby-Teglund, O Hyldegaard
BACKGROUND: The INFECT project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections (NSTIs). The INFECT observational study is part of the INFECT project with the aim of studying the clinical profile of patients with NSTIs and correlating these to patient-important outcomes. With this protocol and statistical analysis plan we describe the methods used to obtain data and the details of the planned analyses. METHODS: The INFECT study is a multicentre, prospective observational cohort study...
October 29, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29069651/staphylococcus-aureus-%C3%AE-toxin-induces-inflammatory-cytokines-via-lysosomal-acid-sphingomyelinase-and-ceramides
#3
Jie Ma, Erich Gulbins, Michael J Edwards, Charles C Caldwell, Martin Fraunholz, Katrin Anne Becker
BACKGROUND/AIMS: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock syndrome. Toxins that are released from S. aureus mediate many of these effects. Here, we aimed to identify molecular mechanisms how α-toxin, a major S. aureus toxin, induces inflammation. METHODS: Macrophages were isolated from the bone marrow of wildtype and acid sphingomyelinase-deficient mice, stimulated with S...
October 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29057807/wound-healing-peptides-for-treatment-of-chronic-diabetic-foot-ulcers-and-other-infected-skin-injuries
#4
REVIEW
Ana Gomes, Cátia Teixeira, Ricardo Ferraz, Cristina Prudêncio, Paula Gomes
As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue...
October 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29054550/-mlva-analysis-and-virulence-profile-of-community-acquired-methicillin-resistant-staphylococcus-aureus-causing-infections-in-paraguayan-children
#5
Fátima Rodríguez Acosta, Wilma D Basualdo Acuña, Héctor Castro, Ana Campuzano, María L Macchi, Juana Ortellado de Canese, Patricia Almada, Mónica Rodríguez, Lorena Grau, Gladys Velázquez, Carmen Espínola, Gloria C Samudio Domínguez, Gloria Gómez, Letizia Carpinelli, Rosa M Guillén Fretes
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the first causes of skin and soft tissue infections, and can also produce severe diseases such as osteomyelitis and pneumonia. The aim of this descriptive study was to determine the SCCmec type and virulence profile and to study the genetic diversity by MLVA analysis of 21 CA-MRSA isolates that infected Paraguayan children in 2010. The SCCmec type and virulence factors were performed by PCR and genetic diversity by MLVA (multiple locus variable analysis)...
October 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29046006/-skin-and-soft-tissue-infections-due-to-corynebacterium-ulcerans-case-reports
#6
Christian Jenssen, Ilona Schwede, Volker Neumann, Cristine Pietsch, Werner Handrick
History and clinical findings We report on three patients suffering from skin and soft tissue infections of the legs due to toxigenic Corynebacterium ulcerans strains. In all three patients, there was a predisposition due to chronic diseases. Three patients had domestic animals (cat, dog) in their households. Investigations and diagnosis A mixed bacterial flora including Corynebacterium ulcerans was found in wound swab samples. Diphtheric toxin was produced by the Corynebacterium ulcerans strains in all three cases...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28978204/a-simple-novel-technique-for-fixing-penrose-drains-in-minor-surgeries-with-advantages-for-remote-outpatient-clinics-a-retrospective-comparison-with-conventional-drain-fixation-in-north-ibaraki-japan
#7
Yoichiro Shibuya, Go Matsumoto, Masahiro Sasaki, Kaoru Sasaki, Koji Adachi, Mitsuru Sekido
INTRODUCTON: In rural areas with few doctors, Penrose drains in minor surgeries for soft tissue trauma or small subcutaneous tumors are sometimes avoided, even though the drain would prevent hematoma, because of the limited availability of professional postsurgical care. The authors developed a simple fixation method for Penrose drains that can be used even in remote areas where a doctor is not present to remove the drain. A retrospective study was conducted to compare this new method of fixing Penrose drains with instances in which the Penrose drain was fixed to skin by conventional suturing...
October 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28971307/non-tuberculous-mycobacterium-bacteraemia-in-a-pregnant-systemic-lupus-erythematosus-sle-patient-a-case-review-and-pooled-case-analysis
#8
REVIEW
Syahrul Sazliyana Shaharir, Narisa Sulaiman Sahari, Zeena Mohamed Fuad, Wan Zul Haikal Wan Zukiman, Nurul Hafizah Mohd Yusof, Anita Sulong, Petrick Periasamy
Non-tuberculous mycobacteria (NTM) are recognized as an important cause of human diseases and infections. It is commonly known to cause infections of the skin, soft tissue infections, and pulmonary infection as well as bacteraemia. We report a challenging case of severe mycobacterium abscessus bacteraemia in a pregnant lady with active systemic lupus erythematous (SLE). A comprehensive literature review of NTM infection among SLE patients was also performed, and pooled analysis of the reported cases, including our case, was done to determine the clinical characteristics and factors associated with poor outcome of NTM infection...
October 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28944569/prognostic-factors-and-treatment-outcomes-for-patients-with-fournier-s-gangrene-a-retrospective-study
#9
Kyung Sook Hong, Hee Jung Yi, Ryung-Ah Lee, Kwang Ho Kim, Soon Sup Chung
Fournier's gangrene is a gas-forming, necrotising soft tissue infection affecting the perineum. It spreads rapidly along the deep fascial planes and is associated with a high mortality rate. With a growing elderly population with comorbidities, the frequency of severe cases of Fournier's gangrene is expected to increase. We retrospectively reviewed 20 patients diagnosed with Fournier's gangrene at our institution from 2003 to 2014 and analysed data. Thirteen patients had diabetes mellitus, two had been diagnosed with liver cirrhosis, and four were chronic alcoholics...
September 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28939917/use-of-a-fibrinogen-thrombin-sponge-in-rhinoplasty
#10
A Berghaus, M San Nicoló, C Jacobi
BACKGROUND: Although several methods have been described to address nasal dorsum augmentation and smoothing of irregularities in rhinoplasty, establishing the ideal method has proven controversial. OBJECTIVE: Here, we introduce a novel technique of cartilage grafting for nasal dorsum augmentation by wrapping cartilage in a fibrinogen- and thrombin-coated collagen patch called TachoSil®. MATERIAL AND METHODS: In a pilot study comprising ten cases, the use of the collagen patch was examined in various indications in rhinoplasty...
September 22, 2017: HNO
https://www.readbyqxmd.com/read/28935337/necrotizing-sweet-syndrome-of-the-upper-extremity-after-elective-hand-surgery
#11
Jason S Lipof, Lisa A Beck, Swapna C Reddy, Richard D Southgate, Kimberly Carney-Young, Warren C Hammert
Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions. A newly described entity, necrotizing Sweet syndrome, is a severe and locally aggressive dermatological condition that clinically and histopathologically resembles a necrotizing soft tissue infection. It is characterized by pathergy, a nonspecific inflammatory response to cutaneous trauma resulting in a propagation of the disease. In contrast to a necrotizing infection, this condition responds to systemic steroids...
September 19, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28932687/multifocal-ulceronecrotic-skin-lesions-a-stigmatizing-case
#12
Fanny-Emmanuelle Bernier, Simon Grandjean Lapierre, Arwa El-Housseini, Mélissa Nantel-Battista, Sapha Barkati
Mycobacterium chelonae is a rapidly growing nontuberculous mycobacteria, ubiquitous in the environment and mostly involved in skin, soft tissue and bone infections. An atypical, severe and multifocal dermatological manifestation of Mycobacterium chelonae infection in an immunocompetent patient is described here. The lesions completely resolved using a multidisciplinary approach. This case emphasizes the important aspects of diagnosis, antimicrobial and surgical management.
2017: IDCases
https://www.readbyqxmd.com/read/28931126/cutaneous-mycobacterium-gordonae-infection-in-an-elderly-diabetic-returned-traveller
#13
Ibrahim Al-Busaidi, Daniel Wong, Andrea K Boggild
Mycobacterium gordonae, a low pathogenicity organism, is rarely implicated in skin and soft tissue infections. We present a 77-year-old returned diabetic traveler from rural Sudan with cutaneous M. gordonae infection. Several months of ciprofloxacin, rifampin and ethambutol led to resolution of his plaque, without signs of recurrence at 6-month follow-up.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28918832/streptococcus-anginosus-group-bacterial-infections
#14
Tasaduq Fazili, Scott Riddell, Deanna Kiska, Tim Endy, Luca Giurgea, Calden Sharngoe, Waleed Javaid
BACKGROUND: The Streptococcus anginosus group (SAG) causes a variety of infections in adults. To better understand the burden of SAG infections and their associated morbidity and mortality, we conducted a retrospective analysis of these infections in adults at a tertiary care center. METHODS: A retrospective review of all cultures positive for SAG in adults and a corresponding review of the patients' medical records were conducted at a tertiary care facility in central New York...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28917384/serious-infections-among-a-large-cohort-of-subjects-with-systemically-treated-psoriasis
#15
COMPARATIVE STUDY
Allison S Dobry, Charles P Quesenberry, G Thomas Ray, Jamie L Geier, Maryam M Asgari
BACKGROUND: Biologic therapy is effective for treatment of moderate-to-severe psoriasis but may be associated with an increased risk for serious infection. OBJECTIVE: To estimate the serious infection rate among patients with psoriasis treated with biologic as compared with nonbiologic systemic agents within a community-based health care delivery setting. METHODS: We identified 5889 adult Kaiser Permanente Northern California health plan members with psoriasis who had ever been treated with systemic therapies and calculated the incidence rates and 95% confidence intervals (CIs) for serious infections over 29,717 person-years of follow-up...
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28904688/cellulitis-in-aged-persons-a-neglected-infection-in-the-literature
#16
Anis Mzabi, Wafa Marrakchi, Zeineb Alaya, Fatma Ben Fredj, Amel Rezgui, Elyès Bouajina, Chedia Laouani Kechrid
Cellulitis is a frequent soft tissue and skin infection. The lower limbs are affected in 70 to 80% of cases. Cellulitis in aged persons is not yet well described in literature. A retrospective descriptive study conducted in the Internal Medicine Department of Sahloul hospital in Sousse in Tunisia. It included patients whose age was up to 65 years old admitted into hospital for cellulitis of the legs, the arms or the face. One hundred fifty eight patients with a mean age of 73 years old (range: 65 to 94 years old) were included...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28900682/treatment-of-staphylococcus-aureus-infections
#17
Michael Z David, Robert S Daum
Staphylococcus aureus, although generally identified as a commensal, is also a common cause of human bacterial infections, including of the skin and other soft tissues, bones, bloodstream, and respiratory tract. The history of S. aureus treatment is marked by the development of resistance to each new class of antistaphylococcal antimicrobial drugs, including the penicillins, sulfonamides, tetracyclines, glycopeptides, and others, complicating therapy. S. aureus isolates identified in the 1960s were sometimes resistant to methicillin, a ß-lactam antimicrobial active initially against a majority S...
September 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28892995/concurrent-acute-glomerulonephritis-and-retropharyngeal-abscess-in-10-year-boy-a-case-report
#18
Sudha Yadav, Deepali Garg, Narain Das Vaswani, Jaya Shankar Kaushik, Seema Rohilla
Postinfectious Glomerulonephritis (PIGN) usually follows 1-2 weeks after respiratory tract infection and 4-6 weeks after skin infection. Acute Glomerulonephritis (AGN) is uncommon with simultaneous severe throat infections. We describe a 10-year-old boy who was presented with high grade fever, dysphagia and tender swelling over left side of neck. Examination also revealed enlarged multiple cervical lymph nodes on the same side of neck. Magnetic Resonance Imaging (MRI) of soft tissue of neck revealed evidence of retropharyngeal abscess...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28882727/newer-glycopeptide-antibiotics-for-treatment-of-complicated-skin-and-soft-tissue-infections-a-systematic-review-network-meta-analysis-and-cost-analysis
#19
REVIEW
Rajender Agarwal, Sarah M Bartsch, Brendan J Kelly, Malinda Prewitt, Yulun Liu, Yong Chen, Craig A Umscheid
OBJECTIVES: Skin and soft tissue infections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancin and oritavancin offer extended dosing intervals. METHODS: We performed a systematic review, network meta-analysis and cost analysis to compare the newer glycopeptides to standard care and each other for the treatment of complicated SSTIs (cSSTI)...
September 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28882017/utility-of-rapid-microbiological-techniques-for-the-diagnosis-of-severe-infections
#20
REVIEW
E Cercenado
Rapid diagnostic microbiological techniques and antimicrobial susceptibility testing are necessary for early and adequate treatment. The utility of old (Gram stain, antigen detection, direct antimicrobial susceptibility testing, chromogenic media) and new techniques (molecular assays, MALDI-TOF) is summarized for the rapid diagnosis of bacteraemia and fungaemia, catheter-related bloodstream infections, pneumonia, meningitis, skin and soft-tissue infections, urinary tract infection, Clostridium difficile infection, viral infections, and tuberculosis...
September 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
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