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Severe skin and soft tissue infections

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https://www.readbyqxmd.com/read/28735116/surgical-technique-of-percutaneous-iliosacral-screw-fixation-in-s3-level-in-unstable-pelvic-fracture-with-closed-degloving-injury-and-morrell-lavallee-lesion-two-case-reports
#1
Ismail H Dilogo, Jessica Fiolin
INTRODUCTION: Percutaneous screw fixation is considered the best option in unstable pelvic fracture with severe soft tissue injury. However, fixation technique at the level of S3 has not been well established. This paper showed the feasible surgical technique of S3 screw insertion in unstable pelvic fracture with severe soft tissue injury. METHODS: We reported 2 cases of unstable pelvic injury of an 11 years old boy with Marvin-Tile (MT) C1 pelvic fracture with sacroiliac (SI) joint disruption, skin avulsion and Morel-Lavallée lesion...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28706447/treatment-patterns-resource-utilization-and-outcomes-among-hospitalized-patients-with-methicillin-resistant-staphylococcus-aureus-complicated-skin-and-soft-tissue-infections-in-lebanon-and-saudi-arabia
#2
Madonna J Matar, Rima Moghnieh, Adel F Alothman, Abdulhakeem O Althaqafi, Thamer H Alenazi, Fayssal M Farahat, Shelby Corman, Caitlyn T Solem, Nirvana Raghubir, Cynthia Macahilig, Seema Haider, Jennifer M Stephens
OBJECTIVES: To describe treatment patterns and medical resource use for methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infections (cSSTI) in Saudi Arabia and Lebanon in terms of drug selection against the infecting pathogen as well as hospital resource utilization and clinical outcomes among patients with these infections. METHODS: This retrospective chart review study evaluated 2011-2012 data from five hospitals in Saudi Arabia and Lebanon...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28705427/invasive-disease-by-streptococcus-pyogenes-patients-hospitalized-for-6-years
#3
Vanessa Arias-Constantí, Victoria Trenchs-Sainz de la Maza, Nuria Elvira Sanz-Marcos, Carmina Guitart-Pardellans, Amadeu Gené-Giralt, Carles Luaces-Cubells
INTRODUCTION AND OBJECTIVE: The last years an increase of severe cases of invasive disease (ID) due to Streptococcus pyogenes or streptococcus b-hemolytic group A (SGA) had been detected. The aim of this study was to analyze the epidemiology and the clinical features of ID due to SGA in a tertiary Pediatric Hospital. MATERIAL AND METHODS: Retrospective study in a Pediatric hospital, of all in-patients with final diagnosis of ID due to SGA during 6 years (2009-2014)...
July 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28701438/community-associated-methicillin-resistant-staphylococcus-aureus-infection-literature-review-and-clinical-update
#4
REVIEW
Kassandra Loewen, Yoko Schreiber, Mike Kirlew, Natalie Bocking, Len Kelly
OBJECTIVE: To provide information on the prevalence and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections and the distinction between community-associated MRSA and health care-associated MRSA. QUALITY OF EVIDENCE: The MEDLINE and EMBASE databases were searched from 2005 to 2016. Epidemiologic studies were summarized and the relevant treatment literature was based on level I evidence. MAIN MESSAGE: The incidence of community-associated MRSA infection is rising...
July 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28698756/treatment-of-decubitis-ulcer-stage-iv-in-the-patient-with-polytrauma-and-vertical-share-pelvic-fracture-diagnosed-entherocollitis-and-deep-wound-infection-with-clostridium-difficile-with-combined-negative-pressure-wound-therapy-npwt-and-faecal-management-system
#5
Slavcho Stojmenski, Igor Merdzanovski, Andrej Gavrilovski, Sofija Pejkova, Gjorge Dzokic, Smilja Tudzarova
AIM: The aim of this paper was to present a case with the successful treatment of decubitis ulcer stage IV in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection with Clostridium difficile treated with combined Negative Pressure Wound Therapy (NPWT) and faecal management system. CASE REPORT: Patient D.S.1967 treated on Traumatology Clinic after tentamen suicide on 9.2.2015 with diagnosis: brain contusion; contusion of thoracal space; vertical share pelvic fracture; open fracture type II of the right calcaneus; fracture of the left calcaneus; fracture on the typical place of the left radius; fracture of the right radius with dislocation...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28682290/prolonged-allograft-survival-in-a-patient-with-chronic-immunosuppression-a-case-report-and-systematic-review
#6
Krishna S Vyas, Chase Burns, Dylan T Ryan, Lesley Wong
A 41-year-old man with past medical history of kidney-liver transplantation requiring chronic immunosuppression presented 2 years posttransplant with a necrotizing soft tissue infection of his right thigh. Serial debridement to remove necrotic tissue was performed, and a Matrix HD Allograft Fenestrated (RTI Surgical, Alachua, FL) was applied. At 5-months post grafting, the patient demonstrated fully vascularized and intact skin. Under normal circumstances, a cadaveric allograft sloughs over several weeks and is not usually considered a permanent solution for wound closure...
June 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28671898/patterns-and-outcomes-associated-with-timeliness-of-initial-crystalloid-resuscitation-in-a-prospective-sepsis-and-septic-shock-cohort
#7
Daniel E Leisman, Chananya Goldman, Martin E Doerfler, Kevin D Masick, Susan Dries, Eric Hamilton, Mangala Narasimhan, Gulrukh Zaidi, Jason A D'Amore, John K D'Angelo
OBJECTIVES: The objectives of this study were to 1) assess patterns of early crystalloid resuscitation provided to sepsis and septic shock patients at initial presentation and 2) determine the association between time to initial crystalloid resuscitation with hospital mortality, mechanical ventilation, ICU utilization, and length of stay. DESIGN: Consecutive-sample observational cohort. SETTING: Nine tertiary and community hospitals over 1...
June 30, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28658756/unusual-severe-extra-intestinal-manifestations-of-a-common-enteric-pathogen-aeromonas-spp
#8
Barnini Banerjee, Mridula Madiyal, Lingadakai Ramchandra, Chiranjay Mukhopadhyay, Rahul Garg, Kiran Chawla
INTRODUCTION: Aeromonas spp. are halophilic, Gram-negative bacilli. They are widely distributed in the soil and aquatic environment and have been associated with various extra-intestinal infections, such as skin and soft-tissue infections, meningitis, bacteraemia etc. The most common species associated with extra-intestinal infection is Aeromonas hydrophila. AIM: To get the overview of clinical presentations, underlying predisposing factors associated with the extra-intestinal infections caused by Aeromonas species and their antimicrobial susceptibility pattern...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656020/group-a-streptococcal-bacteremia-following-streptococcal-pharyngitis-in-an-older-patient-with-diabetes-a-case-report%C3%A2-%C3%A2-%C3%A2
#9
Mehida Alexandre, Ruth Wang'ondu, Leo M Cooney
Group A streptococcus (GAS) is responsible for a wide range of both invasive and noninvasive infections. Severe invasive group A streptococcal infection is associated with morbidity and mortality and has been linked to chronic medical conditions with skin and soft tissues involvement, and intravenous drug use (IVDU). Invasive diseases are, however, rare and have been recognized to affect the extremes of age (younger than 10 years of age and older than 74). We report a case of Group A streptococcus bacteremia following pharyngitis in a 76-year-old diabetic male with no history of IVDU...
June 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28642756/high-prevalence-of-macrolide-resistance-and-molecular-characterization-of-streptococcus-pyogenes-isolates-circulating-in-china-from-2009-to-2016
#10
Binghuai Lu, Yujie Fang, Yanyan Fan, Xingchun Chen, Junrui Wang, Ji Zeng, Yi Li, Zhijun Zhang, Lei Huang, Hongxia Li, Dong Li, Fengxia Zhu, Yanchao Cui, Duochun Wang
Streptococcus pyogenes, or group A Streptococcus, is a pathogen responsible for a wide range of clinical manifestations, from mild skin and soft tissue infections and pharyngitis to severe diseases. Its epidemiological characteristics should be comprehensively under surveillance for regulating the national prevention and treatment practice. Herein, a total of 140 S. pyogenes, including 38 invasive and 102 noninvasive isolates, were collected from infected patients in 10 tertiary general hospitals from 7 cities/provinces in China during the years 2009-2016...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28628457/clonal-clusters-and-virulence-factors-of-group-c-and-g-streptococcus-causing-severe-infections-manitoba-canada-2012-2014
#11
Sylvain A Lother, Walter Demczuk, Irene Martin, Michael Mulvey, Brenden Dufault, Philippe Lagacé-Wiens, Yoav Keynan
The incidence of group C and G Streptococcus (GCGS) bacteremia, which is associated with severe disease and death, is increasing. We characterized clinical features, outcomes, and genetic determinants of GCGS bacteremia for 89 patients in Winnipeg, Manitoba, Canada, who had GCGS bacteremia during 2012-2014. Of the 89 patients, 51% had bacteremia from skin and soft tissue, 70% had severe disease features, and 20% died. Whole-genome sequencing analysis was performed on isolates derived from 89 blood samples and 33 respiratory sample controls: 5 closely related genetic lineages were identified as being more likely to cause invasive disease than non-clade isolates (83% vs...
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28627952/clinical-efficacy-of-piperacillin-tazobactam-in-the-treatment-of-complicated-skin-and-soft-tissue-infections
#12
Kohei Takimoto, Qianzhi Wang, Daisuke Suzuki, Mitsuya Katayama, Yoshiro Hayashi
Complicated skin and soft tissue infections (cSSTIs) are skin and soft tissue infections (SSTIs) that involve deep soft tissue. cSSTIs often require surgical intervention and/or hospitalization. cSSTIs are associated with significant mortality and morbidity, and carry a significant burden on health care systems. Piperacillin/tazobactam has been regarded as a standard treatment for cSSTIs because of its antibiotic spectrum, safety and clinical efficacy. Several antibiotics, as compared to piperacillin/tazobactam, have been evaluated in the treatment of cSSTIs...
July 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28614442/skin-and-soft-tissue-infections-in-the-intensive-care-unit-a-retrospective-study-in-a-tertiary-care-center
#13
Luís Filipe Malheiro, Rita Magano, Alcina Ferreira, António Sarmento, Lurdes Santos
Objective: To identify factors that may influence outcomes in patients with severe skin and soft tissue infections in the intensive care unit. Methods: A retrospective observational study was conducted in a cohort of 1,123 critically ill patients admitted to an intensive care unit with a primary or secondary diagnosis of severe skin and soft tissues infection between January 2006 and December 2014. Results: Thirty patients were included, 20 (66...
June 12, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28600588/-open-reduction-and-internal-fixation-of-lateral-tibial-plateau-fractures-with-free-subchondral-2-7%C3%A2-mm-screws
#14
M Reul, F Johnscher, S Nijs, H Hoekstra
OBJECTIVES: Exact reconstruction of the depressed articular surface and stable subchondral fixation of the lateral tibial plateau (ORIF, "open reduction and internal fixation"). INDICATIONS: Tibial plateau fractures with involvement of the lateral column and depression of the articular surface. CONTRAINDICATIONS: Critical soft tissue. Severe osteoporosis. SURGICAL TECHNIQUE: Supine position, classical anterolateral approach, lateral submeniscal arthrotomy, visualisation of the fracture, osteotomy of the lateral tibial condyle...
June 9, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28592371/low-yield-of-blood-and-wound-cultures-in-patients-with-skin-and-soft-tissue-infections
#15
Jesus Torres, Nathaniel Avalos, Lamarr Echols, Jillian Mongelluzzo, Robert M Rodriguez
BACKGROUND: Current guidelines recommend blood cultures in skin and soft-tissue infection (SSTI) patients only with signs of systemic toxicity and wound cultures for severe purulent infections. Our objectives were to determine: 1) blood and wound culture yields in patients admitted with SSTIs; 2) whether injection drug users (IDUs) and febrile patients had higher blood culture yields; and 3) whether blood and wound cultures grew organisms sensitive to typical SSTI empiric antibiotics...
May 26, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28589426/clinical-condition-and-comorbidity-as-determinants-for-blood-culture-positivity-in-patients-with-skin-and-soft-tissue-infections
#16
F V van Daalen, M C Kallen, C M A van den Bosch, M E J L Hulscher, S E Geerlings, J M Prins
The utility of performing blood cultures in patients with a suspected skin infection is debated. We investigated the association between blood culture positivity rates and patients' clinical condition, including acute disease severity and comorbidity. We performed a retrospective study, including patients with cellulitis and wound infection who had been enrolled in three Dutch multicenter studies between 2011 and 2015. Patients' acute clinical condition was assessed using the Modified Early Warning Score (MEWS; severe: MEWS ≥2) and comorbidity with the Charlson Comorbidity Index (CCI; severe: CCI ≥2)...
June 7, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28569281/a-qualitative-study-of-determinants-of-patient-behaviour-leading-to-an-infection-related-hospital-admission
#17
A P Tonna, A E Weidmann, R B Laing, I Tonna, G M Macartney, V Paudyal, D Stewart
Objectives To describe and understand the determinants of patients' behaviours surrounding admission to hospital for an acute infective episode Method Patients admitted to the infection or acute medicine admission units of a major Scottish teaching hospital and commenced on antibiotic therapy after admission were included. Semi-structured face-to-face interviews were conducted using a pre-piloted interview schedule guide that focused on gathering information about patient behaviours and experiences prior to admission to hospital with an acute infection...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28559026/promotion-of-oral-surgical-wound-healing-using-autologous-mucosal-cell-sheets
#18
Jong-Lyel Roh, Hyejin Jang, Jaewang Lee, Eun Hye Kim, Daiha Shin
OBJECTIVES: Severe oral mucosal and tissue defects can lead to pain, infection, and later undesirable healing of scarring and adhesion, resulting in a poor quality of life. In vitro-engineered oral mucosal equivalents for covering such defects are an alternative to avoiding the donor site morbidity of conventional skin or tissue grafts. We examined the efficacy of our newly developed three-dimensional mucosal cell sheets in an in vivo tongue wound model mimicking the surgical extirpation of tongue cancer...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28523002/humanized-mouse-models-of-staphylococcus-aureus-infection
#19
REVIEW
Dane Parker
Staphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulence factors and host components important for pathogenesis. Although significant effort has gone toward development of an anti-staphylococcal vaccine, antibodies have proven ineffective in preventing infection in humans after successful studies in mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28499779/-treating-through-decision-and-follow-up-in-antibiotic-therapy-associated-exanthemas
#20
Axel Trautmann, Sandrine Benoit, Matthias Goebeler, Johanna Stoevesandt
BACKGROUND: Immediate discontinuation or replacement of suspected drugs is considered standard medical care in acute exanthematous skin reactions. In the treatment of bacterial infections, structurally different alternative antibiotics, however, are commonly second choice options due to a suboptimal antimicrobial activity or an unfavorable side effect profile. Nonetheless, "treating through," the continuation of antibiotic treatment despite an objective exanthema, is practiced only rarely...
May 9, 2017: Journal of Allergy and Clinical Immunology in Practice
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