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Fractional flow reserve

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https://www.readbyqxmd.com/read/29222822/coronary-microvascular-dysfunction-and-myocardial-contractile-reserve-in-women-with-angina-and-no-obstructive-coronary-artery-disease
#1
Marie M Michelsen, Adam Pena, Naja D Mygind, Jan Bech, Ida Gustafsson, Jens Kastrup, Henrik S Hansen, Nis Høst, Peter R Hansen, Eva Prescott
BACKGROUND: Coronary microvascular dysfunction (CMD) is a potential cause of myocardial ischemia and may affect myocardial function at rest and during stress. We investigated whether CMD was associated with left ventricular diastolic and systolic function at rest and during pharmacologically induced hyperemic stress. METHODS: In a prospective cohort study, we included 963 women with angina, left ventricular ejection fraction (LVEF) >45%, and an invasive coronary angiogram without significant stenosis (<50%)...
December 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29209950/spect-myocardial-ischemia-in-the-absence-of-obstructive-cad-contribution-of-the-invasive-assessment-of-microvascular-dysfunction
#2
Loïc Djaïleb, Laurent Riou, Nicolas Piliero, Adrien Carabelli, Estelle Vautrin, Alexis Broisat, Julien Leenhardt, Jacques Machecourt, Daniel Fagret, Gerald Vanzetto, Gilles Barone-Rochette, Catherine Ghezzi
Coronary microvascular dysfunction has recently emerged as a major independent prognostic factor and can be invasively assessed by coronary flow reserve (CFR) and the index of microvascular resistance (IMR). The incremental prognostic value of myocardial ischemia from SPECT myocardial perfusion imaging (MPI) over clinical characteristics, cardiac risk factors, and stress test data for the prediction of hard cardiac events (myocardial infarction and cardiac death) has been well demonstrated over the last two decades regardless of the absence or presence of epicardial CAD...
December 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29198458/clinical-outcomes-according-to-fractional%C3%A2-flow-reserve-or-instantaneous-wave-free-ratio%C3%A2-in%C3%A2-deferred-lesions
#3
Joo Myung Lee, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Jonghanne Park, Kyung-Jin Kim, Jinlong Zhang, Chul Ahn, Bon-Kwon Koo
OBJECTIVES: The authors investigated 2-year clinical outcomes according to fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) values in deferred lesions. BACKGROUND: Invasive physiological indices such as FFR or iFR are used in clinical practice to select ischemia-causing stenosis and to guide the treatment strategy for patients with coronary artery disease. METHODS: From the 3V FFR-FRIENDS (3-Vessel Fractional Flow Reserve for the Assessment of Total Stenosis Burden and Its Clinical Impact in Patients With Coronary Artery Disease) study, 821 deferred lesions (374 patients) with both FFR and iFR available were included in this study...
November 20, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29197253/deep-learning-analysis-of-the-myocardium-in-coronary-ct-angiography-for-identification-of-patients-with-functionally-significant-coronary-artery-stenosis
#4
Majd Zreik, Nikolas Lessmann, Robbert W van Hamersvelt, Jelmer M Wolterink, Michiel Voskuil, Max A Viergever, Tim Leiner, Ivana Išgum
In patients with coronary artery stenoses of intermediate severity, the functional significance needs to be determined. Fractional flow reserve (FFR) measurement, performed during invasive coronary angiography (ICA), is most often used in clinical practice. To reduce the number of ICA procedures, we present a method for automatic identification of patients with functionally significant coronary artery stenoses, employing deep learning analysis of the left ventricle (LV) myocardium in rest coronary CT angiography (CCTA)...
November 26, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29196090/diagnostic-performance-of-stress-perfusion-cardiac-magnetic-resonance-for-the-detection-of-coronary-artery-disease-a-systematic-review-and-meta-analysis
#5
Apostolos Kiaos, Ioannis Tziatzios, Stavros Hadjimiltiades, Charalambos Karvounis, Theodoros D Karamitsos
INTRODUCTION: The purpose of this study was to investigate the accuracy of qualitative stress perfusion cardiac magnetic resonance (CMR) to diagnose ischemia-causing lesions according to different definitions of significant coronary artery disease (CAD), and magnetic field strength. METHODS: We searched PubMed, Web of Science, and the Cochrane Library for studies evaluating diagnostic performance of qualitative stress perfusion CMR for diagnosis of CAD versus coronary angiography or fractional flow reserve (FFR) from inception to 10 September 2017...
November 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29194596/truncated-isoform-vav3-1-is-highly-expressed-in-ovarian-cancer-stem-cells-and-clinically-relevant-in-predicting-prognosis-and-platinum-response
#6
Daniel Reimer, Maximilian Boesch, Dominik Wolf, Christian Marth, Sieghart Sopper, Jiri Hatina, Peter Altevogt, Walther Parson, Hubert Hackl, Alain G Zeimet
Vav3 is a key modulator of GTP-hydrolases of the Rho/Rac family, which are crucially involved in cell proliferation. Vav3 is alternatively spliced in full-length Vav3-alpha and N-terminal truncated Vav3.1 lacking its self-regulatory domains. The aim of this study was to estimate the clinical impact of Vav3 and all other Vav family members in ovarian cancer. Purification of a stem-cell like side-population (SP) from ovarian cancer cell lines was performed by flow cytometry/FACS. Differences in gene expression between SP and NSP were assessed by Gene Array analysis and confirmed by RT-PCR and immunoblot...
December 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29191506/a-practical-guide-for-fractional-flow-reserve-guided-revascularisation
#7
REVIEW
Abdul Rahman Ihdayhid, Andy Yong, Richard Harper, Jamie Rankin, Christopher Wong, Adam J Brown, Michael Leung, Brian Ko
The presence and extent of myocardial ischaemia is a major determinant of prognosis and benefit from revascularisation in patients with stable coronary artery disease. Fractional Flow Reserve (FFR) is accepted as the reference standard for invasive assessment of ischaemia. Its ability to detect lesion specific ischaemia makes it a useful test in a wide range of patient and lesion subsets, with FFR guided intervention improving clinical outcomes and reducing health care costs compared to assessment with coronary angiography alone...
October 20, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29184539/effects-on-subclinical-heart-failure-in-type-2-diabetic-subjects-on-liraglutide-treatment-vs-glimepiride-both-in-combination-with-metformin-a-randomized-open-parallel-group-study
#8
Thomas Nyström, Irene Padro Santos, Fredric Hedberg, Johan Wardell, Nils Witt, Yang Cao, Leif Bojö, Bo Nilsson, Johan Jendle
Objective: We aimed to investigate the effect of liraglutide treatment on heart function in type 2 diabetes (T2D) patients with subclinical heart failure. Methods: Randomized open parallel-group trial. 62 T2D patients (45 male) with subclinical heart failure were randomized to either once daily liraglutide 1.8 mg, or glimepiride 4 mg, both add on to metformin 1 g twice a day. Mitral annular systolic (s') and early diastolic (e') velocities were measured at rest and during bicycle ergometer exercise, using tissue Doppler echocardiography...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29183566/application-of-pressure-derived-myocardial-fractional-flow-reserve-in-chronic-hemodialysis-patients
#9
Kimihiko Hirose, Taishiro Chikamori, Satoshi Hida, Nobuhiro Tanaka, Jun Yamashita, Yuko Igarashi, Tetsushi Saitoh, Hirokazu Tanaka, Akira Yamashina
BACKGROUND: Although fractional flow reserve (FFR) measurements during coronary angiography are performed in routine clinical practice, few studies have evaluated FFR measurements in dialysis patients. METHODS: We retrospectively studied 42 hemodialysis patients with suspected or known coronary artery disease (CAD) who underwent stress myocardial perfusion imaging and coronary angiography with FFR measurements for 61 coronary lesions. The cut-off value for FFR to detect myocardial ischemia was determined by receiver operating characteristic (ROC) curve analysis...
January 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29180265/corrigendum-to-physiologic-mechanism-of-discordance-between-instantaneous-wave-free-ratio-and-fractional-flow-reserve-insight-from-13n-ammonium-positron-emission-tomography-int-j-cardiol-243-2017-91-94
#10
Joo Myung Lee, Doyeon Hwang, Jonghanne Park, Yaliang Tong, Bon-Kwon Koo
No abstract text is available yet for this article.
November 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29171198/ischemia-based-coronary-revascularization-beyond-anatomy-and-fractional-flow-reserve
#11
REVIEW
Hong Seok Lim, Kyoung Woo Seo, Myeong Ho Yoon, Hyoung Mo Yang, Seung Jea Tahk
Treatment strategies for patients with coronary artery disease (CAD) should be based on objective evidence of inducible ischemia in the subtended myocardium to improve clinical outcomes, symptoms, and cost-effectiveness. Fractional flow reserve (FFR) is the most verified index to-date for invasively evaluating lesion-specific myocardial ischemia. Favorable results from large clinical trials that applied FFR-guided percutaneous coronary intervention (PCI) prompted changes in coronary revascularization guidelines to emphasize the importance of this ischemia-based strategy using invasive coronary physiology...
November 6, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29168014/myocardial-perfusion-reserve-quantified-by-cardiac-magnetic-resonance-imaging-is-associated-with-late-gadolinium-enhancement-in-hypertrophic-cardiomyopathy
#12
Daisuke Tezuka, Hisanori Kosuge, Masahiro Terashima, Nozomu Koyama, Tadashi Kishida, Yuko Tada, Jun-Ichi Suzuki, Tetsuo Sasano, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe
Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging has demonstrated the capability of stratifying hypertrophic cardiomyopathy (HCM). Stress perfusion test of CMR can quantify myocardial perfusion reserve (MPR), but its clinical role is not determined. The purpose of this study was to investigate the relationship between MPR and LGE in patients with HCM. A total of 61 consecutive cases underwent complete evaluation with electrocardiography and CMR [cine imaging, coronary MR angiography (MRA), and stress perfusion testing with LGE]...
November 22, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29167881/coronary-computed-tomography-based-fractional-flow-reserve-a-rapidly-developing-field
#13
Stefan Baumann, Matthias Renker, U Joseph Schoepf
No abstract text is available yet for this article.
November 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29167862/coronary-computed-tomography-based-fractional-flow-reserve-reply
#14
Christopher M Cook, Ricardo Petraco, Justin E Davies
No abstract text is available yet for this article.
November 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29162610/angiography-versus-hemodynamics-to-predict-the-natural-history-of-coronary-stenoses-a-fame-2-substudy
#15
Giovanni Ciccarelli, Emanuele Barbato, Gabor G Toth, Brigitta Gahl, Panagiotis Xaplanteris, Stephane Fournier, Anastasios Milkas, Jozef Bartunek, Marc Vanderheyden, Nico Pijls, Pim Tonino, William F Fearon, Peter Jüni, Bernard De Bruyne
Background -Among patients with documented stable coronary artery disease (CAD) and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and of fractional flow reserve (FFR) in predicting natural history. Methods -The present analysis included the 607 patients from the Fractional flow reserve versus angiography in multivessel evaluation 2 (FAME 2) trial in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74 ± 0...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29156145/fractional-flow-reserve-estimated-at-coronary-ct-angiography-in-intermediate-lesions-comparison-of-diagnostic-accuracy-of-different-methods-to-determine-coronary-flow-distribution
#16
Satoru Kishi, Andreas A Giannopoulos, Anji Tang, Nahoko Kato, Yiannis S Chatzizisis, Carole Dennie, Yu Horiuchi, Kengo Tanabe, João A C Lima, Frank J Rybicki, Dimitris Mitsouras
Purpose To compare the diagnostic accuracy of different computed tomographic (CT) fractional flow reserve (FFR) algorithms for vessels with intermediate stenosis. Materials and Methods This cross-sectional HIPAA-compliant and human research committee-approved study applied a four-step CT FFR algorithm in 61 patients (mean age, 69 years ± 10; age range, 29-89 years) with a lesion of intermediate-diameter stenosis (25%-69%) at CT angiography who underwent FFR measurement within 90 days. The per-lesion diagnostic performance of CT FFR was tested for three different approaches to estimate blood flow distribution for CT FFR calculation...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29155383/efficacy-of-optical-coherence-tomography-derived-morphometric-assessment-in-predicting-the-physiological-significance-of-coronary-stenosis-head-to-head-comparison-with-intravascular-ultrasound
#17
Eisuke Usui, Taishi Yonetsu, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
AIMS: This study aimed to investigate the diagnostic efficacy of optical coherence tomography (OCT) in identifying functional significance via fractional flow reserve (FFR) compared with that of intravascular ultrasound (IVUS). METHODS AND RESULTS: We investigated 203 de novo intermediate coronary lesions of 186 patients who underwent frequency-domain OCT, IVUS and FFR measurements. Diagnostic efficacy of the minimal lumen area (MLA) obtained by OCT (OCT-MLA) and IVUS (IVUS-MLA) in predicting an FFR<0...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29154426/microvascular-dysfunction-and-cardiac-fibrosis-in-heart-failure-with-preserved-ejection-fraction-a-case-report
#18
Nikhil Narang, Diego Medvedofsky, Kathryn Dryer, Sanjiv J Shah, Charles J Davidson, Amit R Patel, John E A Blair
We report the case of a 55-year-old woman with heart failure with preserved ejection fraction (HFpEF), who presented with hypertensive urgency and pulmonary oedema. The patient was medically optimized and underwent cardiac catheterization revealing pulmonary hypertension, elevated pulmonary capillary wedge pressure, normal cardiac index, and non-obstructive coronary disease. Invasive evaluation of coronary flow revealed blunted coronary flow reserve and increased index of microvascular resistance. Cardiac magnetic resonance imaging demonstrated reduced global myocardial perfusion and diffuse interstitial fibrosis...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153499/assessment-of-serial-coronary-stenoses-with-noninvasive-ct-derived-fractional-flow-reserve-and-treatment-planning-using-a-novel-virtual-stenting-application
#19
Abdul Rahman Ihdayhid, Anthony White, Brian Ko
No abstract text is available yet for this article.
November 10, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29151547/-the-effect-of-reconstruction-method-on-the-ability-to-analyze-of-ffr-using-ct
#20
Hidekazu Inage, Yosuke Kogure, Kanako Kumamaru, Shinichiro Fujimoto, Kazuhisa Takamura, Yuko Kawaguchi, Htun Han Ni, Haruyoshi Hoshito
BACKGROUND: Invasive-fractional flow reserve (FFR) is the reference standard to evaluate functional ischemia of coronary arteries, and is used to decide if percutaneous transluminal coronary angioplasty is necessary. Recently, computed tomography-derived FFR (CT-FFR) is emerged as an alternative non-invasive method. OBJECTIVES: To evaluate the effect of reconstruction methods and image parameters on the accuracy of CT-FFR calculation. METHODS: A total of 26 segments in the consecutive 10 coronary CT angiography (CCTA) studies were evaluated...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
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