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Fractional flow reserve

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https://www.readbyqxmd.com/read/28724126/comparative-outcomes-after-percutaneous-coronary-intervention-among-black-and-white-patients-treated-at-us-veterans-affairs-hospitals
#1
Taisei Kobayashi, Thomas J Glorioso, Ehrin J Armstrong, Thomas M Maddox, Mary E Plomondon, Gary K Grunwald, Steven M Bradley, Thomas T Tsai, Stephen W Waldo, Sunil V Rao, Subhash Banerjee, Brahmajee K Nallamothu, Deepak L Bhatt, A Garvey Rene, Robert L Wilensky, Peter W Groeneveld, Jay Giri
Importance: Current comparative outcomes among black and white patients treated with percutaneous coronary intervention (PCI) in the Veterans Affairs (VA) health system are not known. Objective: To compare outcomes between black and white patients undergoing PCI in the VA health system. Design, Setting, and Participants: This study compared black and white patients who underwent PCI between October 1, 2007, and September 30, 2013, at 63 VA hospitals using data recorded in the VA Clinical Assessment, Reporting, and Tracking System for Cardiac Catheterization Laboratories (CART-CL) program...
July 19, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28714527/multimodality-imaging-of-intermediate-lesions-data-from-ffr-oct-nirs-ivus
#2
Dariusz Biały, Magdalena Wawrzyńska, Jacek Arkowski, Marcin Rogała, Klaudia Proniewska, Wojciech Wańha, Wojciech Wojakowski, Tomasz Roleder
BACKGROUND: Fractional flow reserve (FFR) assesses a functional impact of the atheroma on the myocardial ischemia, but it does not take into account the morphology of the lesion. Previous optical coherence tomography (OCT), intravascular ultrasound (IVUS) and near infrared spectroscopy (NIRS) studies presented their potential to detect vulnerable plaque, which is not possible by FFR assessment. With the following study, the intermediate lesions were assessed by FFR, OCT and combined NIRS-IVUS imaging to identify plaque vulnerability...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28706598/a-fractional-flow-reserve-guidewire-causing-longitudinal-stent-compression-and-successful-recovery
#3
Metzdorf Pierre-Adrien, Maigrat Charles-Henri, Popovic Batric, Camenzind Edoardo
Longitudinal stent deformation (LSD) is a rare complication but can occur during coronary intervention. We report a case with LSD of the distal edge, documented by an optical coherence tomography investigation and successfully recovered.
April 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28699019/the-diagnostic-performance-of-spect-mpi-to-predict-functional-significant-coronary-artery-disease-by-fractional-flow-reserve-derived-from-ccta-ffrct-sub-analysis-from-accuracy-and-vct001-studies
#4
Rine Nakanishi, Kazuhiro Osawa, Indre Ceponiene, Glenn Huth, Jason Cole, Michael Kim, Negin Nezarat, Sina Rahmani, Dong Li, Souma Gupta, Campbell Rogers, Christopher Dailing, Matthew J Budoff
Although single photon emission computed tomography-myocardial perfusion image (SPECT-MPI) and fractional flow reserve (FFR) derived from coronary computed tomographic angiography (CCTA) (FFRCT) have permitted functional assessment of coronary artery disease (CAD), the concordance between these modalities has not been well described. The aim of this study is to compare SPECT-MPI and anatomical stenosis by CCTA and invasive coronary angiography to FFRCT for assessing functional significance of CAD. We identified 62 patients with suspected CAD who underwent ≥64 slice coronary CTA and SPECT-MPI within 3 months...
July 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28691907/prognosis-of-deferred-non-culprit-lesions-according-to-fractional-flow-reserve-in-patients-with-acute-coronary-syndrome
#5
Joo Myung Lee, Ki Hong Choi, Bon-Kwon Koo, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Hong-Seok Lim, Myeong-Ho Yoon, Seung-Jea Tahk
AIMS: There are limited data on the prognosis of deferred non-culprit lesions in patients with acute coronary syndrome (ACS) based on fractional flow reserve (FFR). We investigated the prognosis of deferred non-culprit lesions in ACS patients, compared with deferred lesions in patients with stable coronary artery disease (SCAD), on the basis of FFR. METHODS AND RESULTS: The clinical outcomes of 449 non-culprit lesions (301 patients with ACS) were compared with 2,484 lesions (1,295 patients with SCAD) in which revascularization was deferred on the basis of a high FFR (>0...
July 11, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28690285/myocardial-bridges-on-coronary-computed-tomography-angiography%C3%A3-correlation-with-intravascular-ultrasound-and-fractional-flow-reserve
#6
Signe Helene Forsdahl, Ian S Rogers, Ingela Schnittger, Shigemitsu Tanaka, Takumi Kimura, Vedant S Pargaonkar, Frandics P Chan, Dominik Fleischmann, Jennifer A Tremmel, Hans-Christoph Becker
BACKGROUND: Myocardial bridges (MB) are commonly seen on coronary CT angiography (CCTA) in asymptomatic individuals, but in patients with recurrent typical angina symptoms, yet no obstructive coronary artery disease (CAD), evaluation of their potential hemodynamic significance is clinically relevant. The aim of this study was to compare CCTA to invasive coronary angiography (ICA), including intravascular ultrasound (IVUS), to confirm MB morphology and estimate their functional significance in symptomatic patients...
July 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28687539/visual-and-quantitative-assessment-of-coronary-stenoses-at-angiography-versus-fractional-flow-reserve-the-impact-of-risk-factors
#7
COMPARATIVE STUDY
Julien Adjedj, Panagiotis Xaplanteris, Gabor Toth, Angela Ferrara, Mariano Pellicano, Giovanni Ciccarelli, Vincent Floré, Emanuele Barbato, Bernard De Bruyne
BACKGROUND: The correlation between angiographic assessment of coronary stenoses and fractional flow reserve (FFR) is weak. Whether and how risk factors impact the diagnostic accuracy of angiography is unknown. We sought to evaluate the diagnostic accuracy of angiography by visual estimate and by quantitative coronary angiography when compared with FFR and evaluate the influence of risk factors (RF) on this accuracy. METHODS AND RESULTS: In 1382 coronary stenoses (1104 patients), percent diameter stenosis by visual estimation (DSVE) and by quantitative coronary angiography (DSQCA) was compared with FFR...
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28685228/relationship-between-coronary-contrast-flow-quantitative-flow-ratio-and-myocardial-ischemia-assessed-by-spect-mpi
#8
Jeff M Smit, Gerhard Koning, Alexander R van Rosendael, Petra Dibbets-Schneider, Bart J Mertens, J Wouter Jukema, Victoria Delgado, Johan H C Reiber, Jeroen J Bax, Arthur J Scholte
PURPOSE: A new method has been developed to calculate fractional flow reserve (FFR) from invasive coronary angiography, the so-called "contrast-flow quantitative flow ratio (cQFR)". Recently, cQFR was compared to invasive FFR in intermediate coronary lesions showing an overall diagnostic accuracy of 85%. The purpose of this study was to investigate the relationship between cQFR and myocardial ischemia assessed by single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)...
July 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28674929/frequency-of-a-large-drift-caused-by-pressure-wire-using-optical-fibers
#9
Yoshiaki Kawase, Toru Tanigaki, Akihiro Hirakawa, Hiroyuki Omori, Tetsuo Hirata, Syuuichi Okamoto, Hideaki Ota, Jun Kikuchi, Munenori Okubo, Hiroki Kamiya, Masanori Kawasaki, Takahiko Suzuki, Hitoshi Matsuo
The frequency of a large pressure signal drift (PDs) caused by pressure wire using optical fibers and its effect on fractional flow reserve (FFR)-based decision-making is not clear. We used pressure wires using optical fibers as "workhorse wires" for 95 consecutive lesions. The wire was normalized at the tip of the guiding catheter just before performing the percutaneous coronary intervention (PCI) and was used without re-normalization until the end of the PCI. The drift value at the end of the procedures was evaluated...
July 3, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28674617/an-ffrct-diagnostic-strategy-versus-usual-care-in-patients-with-suspected-coronary-artery-disease-planned-for-invasive-coronary-angiography-at-german-sites-one-year-results-of-a-subgroup-analysis-of-the-platform-prospective-longitudinal-trial-of-ffrct-outcome
#10
Roisin Colleran, Pamela S Douglas, Martin Hadamitzky, Matthias Gutberlet, Lukas Lehmkuhl, Borek Foldyna, Michael Woinke, Ulrich Hink, Jonathan Nadjiri, Alan Wilk, Furong Wang, Gianluca Pontone, Mark A Hlatky, Campbell Rogers, Robert A Byrne
AIM: Diagnostic evaluation practices for suspected coronary artery disease (CAD) may vary between countries. Our objective was to compare a CT-derived fractional flow reserve (FFRCT) diagnostic strategy with usual care in patients with planned invasive coronary angiography (ICA) enrolled in the PLATFORM (Prospective Longitudinal Trial of FFRCT: Outcome and Resource Impacts) study at German sites. METHODS: Patients were divided into two consecutive observational cohorts, receiving either usual care or CT angiography (CTA)/FFRCT...
2017: Open Heart
https://www.readbyqxmd.com/read/28674091/nitroglycerine-and-angina-evolving-clinical-coronary-physiology-beyond-fractional-flow-reserve-and-coronary-flow-reserve
#11
EDITORIAL
K Lance Gould, Nils P Johnson
No abstract text is available yet for this article.
July 4, 2017: Circulation
https://www.readbyqxmd.com/read/28667757/intracellular-characterization-of-gag-vlp-production-by-transient-transfection-of-hek-293-cells
#12
Laura Cervera, Irene González-Domínguez, Maria Mercedes Segura, Francesc Gòdia
Transient transfection is a fast, flexible, and cost-effective approach to produce biological products. Despite the continued interest in transient transfection, little is known regarding the transfection process at the intracellular level, particularly for complex products, such as virus-like particles (VLPs). The kinetics of PEI-mediated transfection following an established in-house protocol is reported in this work with the aim of characterizing and understanding the complete process leading to VLP generation and identifying important events driving process improvement...
July 1, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28666791/assessing-the-left-main-stem-in-the-cardiac-catheterization-laboratory-what-is-significant-function-imaging-or-both
#13
REVIEW
George Kassimis, Giovanni Luigi de Maria, Niket Patel, Raina Tushar, Peter Scott, Rajesh K Kharbanda, Adrian P Banning
Revascularization of significant Left Main Stem (LMS) disease improves clinical outcomes. This can be achieved through either Coronary Artery Bypass Grafting or Percutaneous coronary intervention. Defining a significant stenosis of the LMS can be challenging and debatable, as most data have been derived using angiographic assessment alone, with a threshold of 50% luminal stenosis used as a marker of functional significance. The use of adjunctive technologies like Intravascular Ultrasound and Fractional Flow Reserve has improved our ability to accurately assess the anatomical severity and physiological significance of coronary artery stenoses, much more so, than can be achieved through conventional angiography alone...
June 20, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28666784/interpreting-results-of-coronary-computed-tomography-angiography-derived-fractional-flow-reserve-in-clinical-practice
#14
REVIEW
Mark G Rabbat, Daniel S Berman, Morton Kern, Gilbert Raff, Kavitha Chinnaiyan, Lynne Koweek, Leslee J Shaw, Philipp Blanke, Markus Scherer, Jesper M Jensen, John Lesser, Bjarne L Nørgaard, Gianluca Pontone, Bernard De Bruyne, Jeroen J Bax, Jonathon Leipsic
The application of computational fluid dynamics to coronary computed tomography angiography allows Fractional Flow Reserve (FFR) to be calculated non-invasively (FFRCT), enabling computation of FFR from coronary computed tomography angiography acquired at rest both for individual lesions as well as along the entire course of a coronary artery. FFRCT, validated in a number of accuracy studies and a large clinical utility trial, is beginning to penetrate clinical practice. Importantly, while accuracy trials compared FFRCT to invasively measured FFR at a single point in the coronary tree, clinical reports of FFRCT provide information regarding a patient's entire coronary vasculature...
June 23, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28653314/fractional-flow-reserve-based-therapy-in-patients-presenting-with-acute-coronary-syndrome-current-data-and-everyday-practice
#15
Grzegorz Zuk, Dariusz Ciecwierz, Natalia Cwalina, Marcin Gruchala, Florim Cuculi
Fractional flow reserve (FFR) is an evidence-based diagnostic tool of physiological significance of coronary artery stenosis in patients with stable coronary artery disease (CAD). Due to microvascular dysfunction in acute coronary syndrome (ACS), information obtained from FFR assessment could be less reliable and, thus, its clinical role remains controversial. Indeed, results of currently published studies are essentially discrepant. Only a few randomized clinical trials have been performed showing the efficacy of FFR-guided percutaneous coronary intervention (PCI) in ACS...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28653312/link-of-renal-microcirculatory-dysfunction-to-increased-coronary-microcirculatory-resistance-in-hypertensive-patients
#16
Cong Lin, Pu Zhang, Yangjing Xue, Yinqing Huang, Kangting Ji
BACKGROUND: This study investigated the correlation between renal microcirculation and coronary microcirculation in hypertensive patients. METHODS: Participants consisted of 231 consecutive candidates who were referred to the Second Affiliated Hospital of Wenzhou Medical University from March 2014 to May 2016 for elective coronary angiography due to suspected myocardial ischemia. All participants were evaluated for the index of microvascular resistance (IMR), coronary flow reserve (CFR), and fractional flow reserve (FFR) using a pressure wire...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28652031/the-utility-of-contrast-medium-fractional-flow-reserve-in-functional-assessment-of-coronary-disease-in-daily-practice
#17
Pieter Van Wyk, Aniket Puri, James Blake, John Michael Elliott, Dougal McClean, Muhammad Arshad, Jacalin Sutherland, Olivia Thacker, Tina Bailey, Ma Yi, David Smyth
BACKGROUND: Adenosine induced hyperaemic fractional flow reserve (aFFR) is a validated predictor of clinical outcome and part of routine interventional practice. Protocol issues associated with the adenosine infusion limit the use of aFFR in clinical practice. Contrast medium induced hyperaemic FFR (cFFR) is a simpler procedure from a practical standpoint. We compared the two in a real world setting. METHODS: We analysed 76 patients that had both cFFR and aFFR assessment of 100 angiographically indeterminate coronary stenosis...
April 22, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28651939/competitive-flow-in-coronary-bypass-surgery-the-roles-of-fractional-flow-reserve-and-arterial-graft-configuration
#18
EDITORIAL
Hugh S Paterson, Paul G Bannon, David P Taggart
No abstract text is available yet for this article.
June 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28651849/meta-analysis-of-head-to-head-comparison-of-intracoronary-versus-intravenous-adenosine-for-the-assessment-of-fractional-flow-reserve
#19
Stefano Rigattieri, Giuseppe Biondi Zoccai, Alessandro Sciahbasi, Cristian Di Russo, Maria Cera, Roberto Patrizi, Silvio Fedele, Andrea Berni, Francesco Rocco Pugliese
Intravenous (IV) infusion of adenosine represents the gold standard for measuring fractional flow reserve (FFR). However, IV adenosine is more expensive and time-consuming compared with intracoronary (IC) boluses of adenosine. We conducted a meta-analysis of studies comparing IC with IV adenosine for FFR assessment in the same coronary lesions. We searched for studies comparing IC with IV adenosine and reporting absolute FFR values or rate of abnormal FFR for both routes. Prespecified subgroup analysis was performed to appraise studies using low-dose (<100 μg) or high-dose IC adenosine (≥100 μg)...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28651585/a-vessel-length-based-method-to-compute-coronary-fractional-flow-reserve-from-optical-coherence-tomography-images
#20
Kyung Eun Lee, Seo Ho Lee, Eun-Seok Shin, Eun Bo Shim
BACKGROUND: Hemodynamic simulation for quantifying fractional flow reserve (FFR) is often performed in a patient-specific geometry of coronary arteries reconstructed from the images from various imaging modalities. Because optical coherence tomography (OCT) images can provide more precise vascular lumen geometry, regardless of stenotic severity, hemodynamic simulation based on OCT images may be effective. The aim of this study is to perform OCT-FFR simulations by coupling a 3D CFD model from geometrically correct OCT images with a LPM based on vessel lengths extracted from CAG data with clinical validations for the present method...
June 26, 2017: Biomedical Engineering Online
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