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Fractional flow reserve

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https://www.readbyqxmd.com/read/28437577/high-gene-flow-despite-opposite-chirality-in-hybrid-zones-between-enantiomorphic-door-snails
#1
Eva L Koch, Marco T Neiber, Frank Walther, Bernhard Hausdorf
We studied differentiation and gene flow patterns between enantiomorphic door-snail species in two hybrid zones in the Bucegi Mountains (Romania) to investigate the effects of intrinsic barriers (complications in copulation) and extrinsic selection by environmental factors. A mitochondrial gene tree confirmed the historical separation of the examined populations into the dextral Alopia livida and the sinistral Alopia straminicollis in accordance with the morphological classification, but also indicated gene flow between the species...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28436268/collateral-circulation-alters-downstream-hemodynamic-stress-caused-by-intracranial-atherosclerotic-stenosis
#2
Xin Liu, David Dornbos, Yuehua Pu, Xinyi Leng, Ligang Song, Baixue Jia, Yuesong Pan, David Wang, Zhongrong Miao, Yilong Wang, Liping Liu, Yongjun Wang
OBJECTIVES: Fractional flow reserve (FFR) accurately predicts the degree of stenosis and is now widely used to identify clinically significant severe coronary artery lesions. In the current study, we utilized a similar indicator, fractional flow (FF), to determine the hemodynamic impact of symptomatic intracranial atherosclerotic stenosis (ICAS) and to assess the correlation of FF with the severity of stenosis and collateral circulation. METHODS: Patients with symptomatic ICAS (70-99% stenosis) confirmed on digital subtraction angiography (DSA) were consecutively recruited...
April 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/28429699/quantitative-assessment-of-the-effect-of-subclavian-steal-syndrome-on-left-anterior-descending-artery-flow
#3
Hasan Arı, Selma Arı, Sencer Camcı, Alper Karakuş, Mehmet Melek
We presented a case of subclavian steal syndrome which has been evaluated and treated quantitatively by using fractional flow reserve technique. Treatment strategy to resolve symptoms of angina in patients with steal syndrome is controversial. Quantitative evaluation should direct choice of treatment strategy.
April 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28420802/clinical-decision-making-for-the-hemodynamic-gray-zone-ffr-0-75-0-80-and-long-term-outcomes
#4
Shiv Kumar Agarwal, Srikanth Kasula, Mohan M Edupuganti, Sameer Raina, Fnu Shailesh, Ahmed Almomani, Jason J Payne, Naga V Pothineni, Barry F Uretsky, Abdul Hakeem
BACKGROUND: Fractional flow reserve (FFR) value between 0.75 and 0.80 is considered the "gray zone" and outcomes data relative to treatment strategy (revascularization vs medical therapy alone [deferral]) are limited for this group. METHODS AND RESULTS: A total of 238 patients (64.3 ± 8.6 years; 97% male; 45% diabetic) with gray-zone FFR were followed for the primary endpoint of major adverse cardiovascular event (MACE), defined as a composite of death, myocardial infarction (MI), and target-vessel revascularization...
April 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28419280/fractional-flow-reserve-and-pressure-bounded-coronary-flow-reserve-to-predict-outcomes-in-coronary-artery-disease
#5
Jung-Min Ahn, Frederik M Zimmermann, Nils P Johnson, Eun-Seok Shin, Bon-Kwon Koo, Pil Hyung Lee, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Nico H J Pijls, Seung-Jung Park
Aims: Fractional flow reserve (FFR) has proven to its prognostic and therapeutic value. However, the additive prognostic value of coronary flow reserve (CFR) remains unclear. This study sought to investigate the clinical utility of combined FFR and CFR measurements to predict outcomes. Methods and results: Using the prospective, multicentre Interventional Cardiology Research Incooperation Society-FFR registry, a total of 2088 lesions from 1837 patients were included in this substudy...
April 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28413187/noninvasive-fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography%C3%A3-is-this-just-another-new-diagnostic-test-or-the-long-awaited-game-changer
#6
Hiromasa Otake, Charles A Taylor, Hitoshi Matsuo, Nobuhiro Tanaka, Takashi Akasaka
Despite the clinical importance of ischemia evaluation, obtaining fractional flow reserve (FFR) value has, heretofore, only been available during invasive cardiac catheterization. Although there is a clear linkage between morphology and physiology, a significant gap still exists. FFR derived from coronary computed tomography angiography (FFRCT) is a novel method of quantifying the hemodynamic significance of coronary artery stenoses by translating morphological information into hemodynamic data. Improved diagnostic performance of FFRCThas been repeatedly demonstrated in comparison with coronary computed tomography angiography alone with an invasive FFR reference standard...
April 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28413112/the-effect-of-negative-remodeling-on-fractional-flow-reserve-after-cardiac-transplantation
#7
William F Fearon, Robert Felix, Atsushi Hirohata, Ryota Sakurai, Powell O Jose, Masao Yamasaki, Mamoo Nakamura, Peter J Fitzgerald, Hannah A Valantine, Paul G Yock, Alan C Yeung
BACKGROUND: Negative remodeling is a common occurrence early after cardiac transplantation. Its impact on the development of myocardial ischemia is not well documented. The aim of this study is to investigate the impact of negative remodeling on fractional flow reserve after cardiac transplantation. METHODS: Thirty-four cardiac transplant recipients underwent intravascular ultrasound (IVUS) and fractional flow reserve (FFR) assessment soon after transplantation and one year later...
April 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28412436/noninvasive-ffr-derived-from-coronary-ct-angiography-management-and-outcomes-in-the-promise-trial
#8
Michael T Lu, Maros Ferencik, Rhonda S Roberts, Kerry L Lee, Alexander Ivanov, Elizabeth Adami, Daniel B Mark, Farouc A Jaffer, Jonathon A Leipsic, Pamela S Douglas, Udo Hoffmann
OBJECTIVES: The purpose of this study was to determine whether noninvasive fractional flow reserve derived from computed tomography (FFRCT) predicts coronary revascularization and outcomes and whether its addition improves efficiency of referral to invasive coronary angiography (ICA) after coronary computed tomography angiography (CTA). BACKGROUND: FFRCT may improve the efficiency of an anatomic CTA strategy for stable chest pain. METHODS: This observational cohort study included patients with stable chest pain in the PROMISE trial (PROspective Multicenter Imaging Study for Evaluation of Chest Pain) referred to ICA within 90 days after CTA...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28407768/a-study-of-noninvasive-fractional-flow-reserve-derived-from-a-simplified-method-based-on-coronary-computed-tomography-angiography-in-suspected-coronary-artery-disease
#9
Changzheng Shi, Dong Zhang, Kunlin Cao, Tao Zhang, Liangping Luo, Xin Liu, Heye Zhang
BACKGROUND: The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of FFRCTA requires further evaluation. OBJECTIVES: The aim of this study was to investigate the diagnostic performance of FFRCTA calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making...
April 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28404623/fractional-flow-reserve-guided-complete-revascularization-improves-the-prognosis-in-patients-with-st-segment-elevation-myocardial-infarction-and-severe-nonculprit-disease-a-danami-3-primulti-substudy-primary-pci-in-patients-with-st-elevation-myocardial-infarction
#10
Jacob Lønborg, Thomas Engstrøm, Henning Kelbæk, Steffen Helqvist, Lene Kløvgaard, Lene Holmvang, Frants Pedersen, Erik Jørgensen, Kari Saunamäki, Peter Clemmensen, Ole De Backer, Jan Ravkilde, Hans-Henrik Tilsted, Anton Boel Villadsen, Jens Aarøe, Svend Eggert Jensen, Bent Raungaard, Lars Køber, Dan Eik Høfsten
BACKGROUND: The impact of disease severity on the outcome after complete revascularization in patients with ST-segment-elevation myocardial infarction and multivessel disease is uncertain. The objective of this post hoc study was to evaluate the impact of number of diseased vessel, lesion location, and severity of the noninfarct-related stenosis on the effect of fractional flow reserve-guided complete revascularization. METHODS AND RESULTS: In the DANAMI-3-PRIMULTI study (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization), we randomized 627 ST-segment-elevation myocardial infarction patients to fractional flow reserve-guided complete revascularization or infarct-related percutaneous coronary intervention only...
April 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28389506/dynamic-computed-tomography-myocardial-perfusion-imaging-comparison-of-clinical-analysis-methods-for-the-detection-of-vessel-specific-ischemia
#11
Alexia Rossi, Andrew Wragg, Ernst Klotz, Federica Pirro, James C Moon, Koen Nieman, Francesca Pugliese
BACKGROUND: The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization. The objective of this prospective study was to compare different analysis approaches to diagnose ischemia in patients with stable angina referred for invasive coronary angiography. METHODS AND RESULTS: Patients referred for evaluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial perfusion imaging with a second-generation dual-source scanner...
April 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28383763/upregulated-mir-132-in-lgr5-gastric-cancer-stem-cell-like-cells-contributes-to-cisplatin-resistance-via-sirt1-creb-abcg2-signaling-pathway
#12
Lanfang Zhang, Xiaohe Guo, Dezhong Zhang, Yingying Fan, Lei Qin, Shuping Dong, Lanfang Zhang
Cisplatin resistance has long been a major problem that restricts its use. A novel paradigm in tumor biology suggests that gastric tumor chemo-resistance is driven by gastric cancer stem cell-like (GCSCs). Growing evidence has indicated that microRNAs (miRNAs) contributes to chemo-resistance in gastric cancer (GC). Here, Lgr5(+) cells derived from gastric cancer cell lines displayed stem cell-like features. Flow cytometry demonstrated the presence of a variable fraction of Lgr5 in 19 out of 20 GC specimens...
April 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28381739/a-comparison-between-the-instantaneous-wave-free-ratio-and-resting-distal-coronary-artery-pressure-aortic-pressure-and-the-fractional-flow-reserve-the-diagnostic-accuracy-can-be-improved-by-the-use-of-both-indices
#13
Nobuo Shiode, Tomokazu Okimoto, Hiromichi Tamekiyo, Tomoharu Kawase, Kenichi Yamane, Yuzo Kagawa, Yuto Fujii, Yusuke Ueda, Naoya Hironobe, Yasuko Kato, Yasuhiko Hayashi
Objectives The fractional flow reserve (FFR) is an index of the severity of coronary stenosis that has been clinically validated in several studies. The instantaneous wave-free ratio (iFR) and the resting distal coronary artery pressure/aortic pressure (Pd/Pa) are nonhyperemic pressure-derived indices of the severity of stenosis. This study sought to examine the diagnostic accuracy of the iFR and resting Pd/Pa with respect to hyperemic FFR. Methods Following an intracoronary injection of papaverine, the iFR, resting Pd/Pa, and FFR were continuously measured in 123 lesions in 103 patients with stable coronary disease...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28365268/diagnostic-performance-of-resting-and-hyperemic-invasive-physiological-indices-to-define-myocardial-ischemia-validation-with-13-n-ammonia-positron-emission-tomography
#14
Doyeon Hwang, Ki-Hyun Jeon, Joo Myung Lee, Jonghanne Park, Chee Hae Kim, Yaliang Tong, Jinlong Zhang, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Sang-Hoon Na, Gi Jeong Cheon, Christopher M Cook, Justin E Davies, Bon-Kwon Koo
OBJECTIVES: The authors sought to compare the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and resting distal coronary artery pressure/aortic pressure (Pd/Pa) using (13)N-ammonia positron emission tomography (PET). BACKGROUND: The diagnostic performance of invasive physiological indices was reported to be different according to the reference to define the presence of myocardial ischemia. METHODS: A total of 115 consecutive patients with left anterior descending artery stenosis who underwent both (13)N-ammonia PET and invasive physiological measurement were included...
March 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28365266/effect-of-coronary-anatomy-and-hydrostatic-pressure-on-intracoronary-indices-of-stenosis%C3%A2-severity
#15
Tobias Härle, Mareike Luz, Sven Meyer, Kay Kronberg, Britta Nickau, Javier Escaned, Justin Davies, Albrecht Elsässer
OBJECTIVES: The authors sought to analyze height differences within the coronary artery tree in patients in a supine position and to quantify the impact of hydrostatic pressure on intracoronary pressure measurements in vitro. BACKGROUND: Although pressure equalization of the pressure sensor and the systemic pressure at the catheter tip is mandatory in intracoronary pressure measurements, subsequent measurements may be influenced by hydrostatic pressure related to the coronary anatomy in the supine position...
March 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28356440/fractional-flow-reserve-and-cardiac-events-in-coronary-artery-disease-data-from-a-prospective-registry
#16
Jung-Min Ahn, Duk-Woo Park, Eun-Seok Shin, Bon-Kwon Koo, Chang-Wook Nam, Joon-Hyung Doh, June Hong Kim, In-Ho Chae, Jung-Han Yoon, Sung-Ho Her, Ki-Bae Seung, Woo-Young Chung, Sang-Yong Yoo, Jin Bae Lee, Si Wan Choi, Kyungil Park, Taek Jong Hong, Sang Yeub Lee, Minkyu Han, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Background -We evaluated the prognosis of deferred and revascularized coronary stenoses after FFR measurement to assess its revascularization threshold in clinical practice. Methods -The IRIS-FFR registry prospectively enrolled 5846 patients with at least one coronary lesion with FFR measurement. Revascularization was deferred in 6468 lesions and performed in 2165 lesions after FFR assessment. The primary endpoint was major adverse cardiac events (MACE; cardiac death, myocardial infarction, and repeat revascularization) at a median follow-up of 1...
March 29, 2017: Circulation
https://www.readbyqxmd.com/read/28353154/physiome-approach-for-the-analysis-of-vascular-flow-reserve-in-the-heart-and-brain
#17
REVIEW
Kyung Eun Lee, Ah-Jin Ryu, Eun-Seok Shin, Eun Bo Shim
This work reviews the key aspects of coronary and neurovascular flow reserves with an emphasis on physiomic modeling characteristics by the use of a variety of numerical approaches. First, we explain the definition of fractional flow reserve (FFR) in coronary artery and introduce its clinical significance. Then, computational researches for obtaining FFR are reviewed, and their clinical outcomes are compared. In the case of cerebrovascular reserve (CVR), in spite of substantial progress in the simulation of cerebral hemodynamics, only a few computational studies exist...
March 28, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28344614/do-we-need-invasive-confirmation-of-cardiac-magnetic-resonance-results
#18
Paweł Siastała, Jacek Kądziela, Łukasz A Małek, Mateusz Śpiewak, Katarzyna Lech, Adam Witkowski
INTRODUCTION: Coronary artery revascularization is indicated in patients with documented significant obstruction of coronary blood flow associated with a large area of myocardial ischemia and/or untreatable symptoms. There are a few invasive or noninvasive methods that can provide information about the functional results of coronary artery narrowing. The application of more than one method of ischemia detection in one patient to reevaluate the indications for revascularization is used in case of atypical or no symptoms and/or borderline stenosis...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28335895/coronary-collaterals-function-and-clinical-outcome-between-patients-with-acute-and-chronic-total-occlusion
#19
Jang Hoon Lee, Chang-Yeon Kim, Namkyun Kim, Se Yong Jang, Myung Hwan Bae, Dong Heon Yang, Yongkeun Cho, Shung Chull Chae, Hun Sik Park
OBJECTIVES: This study sought to demonstrate how changes in the collateral function and its clinical significance before and after percutaneous coronary interventions (PCIs) are compared between patients with acute coronary syndrome and total or nearly total occlusions (ATOs) and chronic total occlusions (CTOs). BACKGROUND: The functional relevance of the collateral circulation in patients with ATOs and CTOs has not been fully investigated. METHODS: The pressure-derived collateral pressure index (CPI), myocardial fractional flow reserve (FFRmyo), and coronary fractional flow reserve (FFRcor) at maximum hyperemia induced by intravenous adenosine were evaluated in occluded vessels at baseline, after the PCI, and at 1 year in 23 ATO and 74 CTO patients...
March 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28331135/applicability-of-3-dimensional-quantitative-coronary-angiography-derived-computed-fractional-flow-reserve-for-intermediate-coronary-stenosis
#20
Kyoichiro Yazaki, Masato Otsuka, Shohei Kataoka, Mitsuru Kahata, Asako Kumagai, Koji Inoue, Hiroshi Koganei, Kenji Enta, Yasuhiro Ishii
BACKGROUND: Quantitative flow ratio (QFR) is a newly developed image-based index for estimating fractional flow reserve (FFR).Methods and Results:We analyzed 151 coronary arteries with intermediate stenosis in 142 patients undergoing wire-based FFR measurement using dedicated software. Predefined contrast flow QFR, which was derived from 3-dimensional quantitative coronary angiography (3-D QCA) withThrombolysis in Myocardial Infarction (TIMI) frame counts, was compared with FFR as a reference...
March 22, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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