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https://www.readbyqxmd.com/read/28109039/nkx2-5-regulates-endothelin-converting-enzyme-1-during-pharyngeal-arch-patterning
#1
Jennifer M Iklé, Andre L P Tavares, Marisol King, Hailei Ding, Sophie Colombo, Beth A Firulli, Anthony B Fiulli, Kimara L Targoff, Deborah Yelon, David E Clouthier
In gnathostomes, dorsoventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches is crucial for the development of hinged jaws. One of the key signals that mediates this process is Endothelin-1 (EDN1). Loss of EDN1 binding to the Endothelin-A receptor (EDNRA) results in loss of EDNRA signaling and subsequent facial birth defects in humans, mice and zebrafish. A rate-limiting step in this crucial signaling pathway is the conversion of immature EDN1 into a mature active form by Endothelin converting enzyme-1 (ECE1)...
January 20, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28107797/emotional-capture-by-fearful-expressions-varies-with-psychopathic-traits
#2
Saz P Ahmed, Sara Hodsoll, Polly Dalton, Catherine L Sebastian
Task-irrelevant emotional expressions are known to capture attention, with the extent of "emotional capture" varying with psychopathic traits in antisocial samples. We investigated whether this variation extends throughout the continuum of psychopathic traits (and co-occurring trait anxiety) in a community sample. Participants (N = 85) searched for a target face among facial distractors. As predicted, angry and fearful faces interfered with search, indicated by slower reaction times relative to neutral faces...
January 20, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28101324/oxytocin-for-frontotemporal-dementia-a-systematic-review
#3
REVIEW
Rajesh R Tampi, Michael Maksimowski, Mohsina Ahmed, Deena J Tampi
BACKGROUND: The aim of this systematic review is to identify published randomized controlled trials (RCTs) that evaluated the use of oxytocin in individuals with frontotemporal dementia (FTD). METHODS: A literature search was conducted of PubMed, MEDLINE, EMBASE, PsycINFO and Cochrane collaboration databases for RCTs in any language that evaluated the use of oxytocin in individuals with FTD. Bibliographic databases of published articles were also searched for additional studies...
January 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28099136/alexithymia-and-automatic-processing-of-emotional-stimuli-a-systematic-review
#4
Uta-Susan Donges, Thomas Suslow
Alexithymia is a personality trait characterized by difficulties in recognizing and verbalizing emotions and the utilization of a cognitive style that is oriented toward external events, rather than intrapsychic experiences. Alexithymia is considered a vulnerability factor influencing onset and course of many psychiatric disorders. Even though emotions are, in general, elicited involuntarily and emerge without conscious effort, it is surprising that little attention in etiological considerations concerning alexithymia has been given to deficits in automatic emotion processing and their neurobiological bases...
January 18, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28098859/dna-damage-response-defect-in-williams-beuren-syndrome
#5
David Guenat, Giuseppe Merla, Eric Deconinck, Christophe Borg, Pierre-Simon Rohrlich
Williams-Beuren syndrome (WBS, no. OMIM 194050) is a rare multisystem genetic disorder caused by a microdeletion on chromosome 7q11.23 and characterized by cardiovascular malformations, mental retardation, and a specific facial dysmorphism. Recently, we reported that a series of non‑Hodgkin's lymphoma occurs in children with WBS and thus hypothesized that a predisposition to cancer may be associated with this genetic disorder. The aim of the present study was to ascertain the role played by three genes hemizygously deleted in WBS (RFC2, GTF2I and BAZ1B) in DNA damage response pathways...
January 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28098494/constant-and-variable-time-delays-of-synchrony-of-facial-expressions-in-dyadic-conversations
#6
M Joseph Meyer
No abstract text is available yet for this article.
January 18, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28097516/are-event-related-potentials-to-dynamic-facial-expressions-of-emotion-related-to-individual-differences-in-the-accuracy-of-processing-facial-expressions-and-identity
#7
Guillermo Recio, Oliver Wilhelm, Werner Sommer, Andrea Hildebrandt
Despite a wealth of knowledge about the neural mechanisms behind emotional facial expression processing, little is known about how they relate to individual differences in social cognition abilities. We studied individual differences in the event-related potentials (ERPs) elicited by dynamic facial expressions. First, we assessed the latent structure of the ERPs, reflecting structural face processing in the N170, and the allocation of processing resources and reflexive attention to emotionally salient stimuli, in the early posterior negativity (EPN) and the late positive complex (LPC)...
January 17, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28097286/-pain-therapy-in-small-pets
#8
Sabine Tacke, Andrea Gollwitzer, Lukas Grammel, Julia Henke
Although many advances in pain therapy have been made in recent years, pain therapy is more difficult in the small domestic animal than in cats and dogs. However, there is the ethical obligation that these animals also receive adequate pain therapy. An analgesic is rarely authorized for use in small pets, with pharmacological investigations often lacking and dosages frequently only determined empirically. The small size of the animals often requires a higher dose per kilogram bodyweight compared to cats and dogs...
January 17, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28095998/the-feasibility-and-clinical-benefits-of-improving-facial-affect-recognition-impairments-in-schizophrenia-systematic-review-and-meta-analysis
#9
REVIEW
Natalie Bordon, Suzanne O'Rourke, Paul Hutton
BACKGROUND: People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psychotic symptoms and reduced social functioning. It remains unclear whether this impairment is responsive to non-pharmacological intervention, or what the effect of modifying it is. METHODS: We did a systematic review and meta-analysis to examine whether and to what extent facial affect recognition impairments can be improved by psychological intervention and, if so, whether this leads to improvements in psychotic symptoms and social functioning...
January 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28093475/hippocampal-contribution-to-context-encoding-across-development-is-disrupted-following-early-life-adversity
#10
Hilary K Lambert, Margaret A Sheridan, Kelly Sambrook, Maya Rosen, Mary K Askren, Katie A McLaughlin
: Context can drastically influence responses to environmental stimuli. For example, a gunshot should provoke a different response at a public park than a shooting range. Little is known about how contextual processing and neural correlates change across human development or about individual differences related to early environmental experiences. Children (N=60; 8-19 years, 24 exposed to interpersonal violence) completed a context encoding task during fMRI scanning using a delayed match-to-sample design with neutral, happy, and angry facial cues embedded in realistic background scenes...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28092789/facial-emotion-recognition-among-typically-developing-young-children-a-psychometric-validation-of-a-subset-of-nimstim-stimuli
#11
Lucy Barnard-Brak, Layla Abby, David M Richman, Steven Chesnut
We evaluated the psychometric properties of NimStim taking into account the effects of chronological age on the ability of typically developing young children (aged 2-6 years old) to recognize basic facial expressions (i.e., happy, sad, angry, and fearful). We also examined the psychometric sufficiency of NimStim under race-matched and -mismatched facial emotion stimuli. In the current study, race-matched stimuli referred to when children with African American backgrounds received African American faces to rate their emotions and vice versa for race-mismatched stimuli...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28092781/social-consequences-of-subclinical-negative-symptoms-an-emg-study-of-facial-expressions-within-a-social-interaction
#12
Marcel Riehle, Tania M Lincoln
BACKGROUND AND OBJECTIVES: The negative symptoms of schizophrenia are related to lower social functioning even in non-clinical samples, but little is known about the distinct social consequences of motivational and expressive negative symptoms. In this study we focused on expressive negative symptoms and examined how these symptoms and varying degrees of pro-social facial expressiveness (smiling and mimicry of smiling) relate to the social evaluations by face-to-face interaction partners and to social support...
January 10, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28091349/intranasal-oxytocin-increases-facial-expressivity-but-not-ratings-of-trustworthiness-in-patients-with-schizophrenia-and-healthy-controls
#13
J D Woolley, B Chuang, C Fussell, S Scherer, B Biagianti, D Fulford, D H Mathalon, S Vinogradov
BACKGROUND: Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial effects when administered intranasally to healthy individuals and shows promise in decreasing negative symptoms and enhancing social cognition in schizophrenia...
January 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28090698/presentation-and-validation-of-the-duckees-child-and-adolescent-dynamic-facial-expressions-stimulus-set
#14
Nicole R Giuliani, John C Flournoy, Elizabeth J Ivie, Arielle Von Hippel, Jennifer H Pfeifer
The stimulus sets presently used to study emotion processing are primarily static pictures of individuals (primarily adults) making emotional facial expressions. However, the dynamic, stereotyped movements associated with emotional expressions contain rich information missing from static pictures, such as the difference between happiness and pride. We created a set of 1.1 s dynamic emotional facial stimuli representing boys and girls aged 8-18. A separate group of 36 individuals (mean [M] age = 19.5 years, standard deviation [SD] = 1...
January 16, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28089714/effects-of-touch-on-emotional-face-processing-a-study-of-event-related-potentials-facial-emg-and-cardiac-activity
#15
M M Spapé, Ville Harjunen, N Ravaja
Being touched is known to affect emotion, and even a casual touch can elicit positive feelings and affinity. Psychophysiological studies have recently shown that tactile primes affect visual evoked potentials to emotional stimuli, suggesting altered affective stimulus processing. As, however, these studies approached emotion from a purely unidimensional perspective, it remains unclear whether touch biases emotional evaluation or a more general feature such as salience. Here, we investigated how simple tactile primes modulate event related potentials (ERPs), facial EMG and cardiac response to pictures of facial expressions of emotion...
January 12, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28089707/understanding-infant-eating-behaviour-lessons-learned-from-observation
#16
REVIEW
Marion M Hetherington
Observations of human infants during feeding presents a rich source of data to identify the ways in which hunger, appetite and satiety are communicated in early life. Infants signal appetite through their interest or disinterest in food using a series of communication cues from rapid and transient facial expressions to subtle or potent gestures and bodily movements through to vocalisations and eventually speech. Even in the first days of life facial expressions in response to basic tastes are clearly demonstrated and shared between human infants, other primates and the rat...
January 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28089432/daily-living-pain-assessment-in-children-with-autism-exploratory-study
#17
A Dubois, C Michelon, C Rattaz, M Zabalia, A Baghdadli
This study aims to broaden knowledge about pain expression and assessment in daily life situations in children with Autism Spectrum Disorder (ASD). The goals are to provide a description of the responses of the GED-DI, the French version of the NCCPC, and to test the internal structure validity of this scale. Thirty five children with ASD were included in this study (mean age=58months; mean developmental age=32months). The French version of the NCCPC was filled in by parents. Descriptive analysis of responses shows that children with ASD express pain through varied and common behaviours, related to different expressive markers (vocal, facial, activity, etc...
January 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28086757/a-combination-of-genetic-and-biochemical-analyses-for-the-diagnosis-of-pi3k-akt-mtor-pathway-associated-megalencephaly
#18
Yutaka Negishi, Fuyuki Miya, Ayako Hattori, Yoshikazu Johmura, Motoo Nakagawa, Naoki Ando, Ikumi Hori, Takao Togawa, Kohei Aoyama, Kei Ohashi, Shinobu Fukumura, Seiji Mizuno, Ayako Umemura, Yoko Kishimoto, Nobuhiko Okamoto, Mitsuhiro Kato, Tatsuhiko Tsunoda, Mami Yamasaki, Yonehiro Kanemura, Kenjiro Kosaki, Makoto Nakanishi, Shinji Saitoh
BACKGROUND: Constitutive activation of the PI3K-AKT-mTOR pathway (mTOR pathway) underlies megalencephaly in many patients. Yet, prevalence of the involvement of the PI3K-AKT-mTOR pathway in patients with megalencephaly remains to be elucidated, and molecular diagnosis is challenging. Here, we have successfully established a combination of genetic and biochemical methods for diagnosis of mTOR pathway-associated megalencephaly, and have attempted to delineate the clinical characteristics of the disorder...
January 13, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28080090/we-are-sorry-they-don-t-care-misinterpretation-of-facial-embarrassment-displays-in-arab-white-intergroup-contexts
#19
Pum Kommattam, Kai J Jonas, Agneta H Fischer
Embarrassment displays show others that one is aware of one's own misbehavior and willing to make up for it. The facial actions of embarrassment, however, are partly similar to those of disinterest, which has an opposite function, signaling that one is not concerned about one's self in relation to others. In the context of negative intergroup relations, embarrassment displays of outgroup members may therefore be misinterpreted as disinterest. In the present research, the authors predicted that Whites would perceive Arab expressions of embarrassment more as disinterest, but embarrassment displays of Whites more as embarrassment...
January 12, 2017: Emotion
https://www.readbyqxmd.com/read/28079852/ichthyosiform-sarcoidosis-report-of-three-cases-from-japan-and-literature-review
#20
Takako Miura, Yasunobu Kato, Toshiyuki Yamamoto
Cutaneous lesions of sarcoidosis present with various manifestations including specific and non-specific cutaneous lesions. Ichthyosiform sarcoidosis is a rare form of cutaneous sarcoidosis, presenting with asymptomatic, adherent, polygonal scales, mainly appearing on the lower limbs.  Ichthyosiform sarcoidosis has a predilection for dark-skinned races, and cases affecting Japanese patients have rarely been reported in English literature.  We herein describe three Japanese cases of ichthyosiform sarcoidosis on the lower limbs...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
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