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https://www.readbyqxmd.com/read/28228557/surfactant-protein-a-inhibits-growth-and-adherence-of-uropathogenic-escherichia-coli-to-protect-the-bladder-from-infection
#1
Jiro Hashimoto, Motoko Takahashi, Atsushi Saito, Masaki Murata, Yuichiro Kurimura, Chiaki Nishitani, Rina Takamiya, Yasuaki Uehara, Yoshihiro Hasegawa, Yoshiki Hiyama, Norimasa Sawada, Satoshi Takahashi, Naoya Masumori, Yoshio Kuroki, Shigeru Ariki
Surfactant protein A (SP-A) is a multifunctional host defense collectin that was first identified as a component of pulmonary surfactant. Although SP-A is also expressed in various tissues, including the urinary tract, its innate immune functions in nonpulmonary tissues are poorly understood. In this study, we demonstrated that adherence of uropathogenic Escherichia coli (UPEC) to the bladder was enhanced in SP-A-deficient mice, which suggests that SP-A plays an important role in innate immunity against UPEC...
February 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28217700/the-multiple-antibacterial-activities-of-the-bladder-epithelium
#2
REVIEW
Jianxuan Wu, Yuxuan Miao, Soman N Abraham
The urinary tract is subject to frequent challenges from the gut microflora. Indeed, up to 40% of women will experience at least one urinary tract infection (UTI) during their lifetime. Uropathogenic Escherichia coli (UPEC) contribute to an overwhelming majority of these cases and they typically initiate UTIs by invading the superficial epithelium that lines the bladder lumen. In addition to serving as an effective barrier to noxious agents found in urine, bladder epithelial cells (BECs) play a key physiological role in regulating bladder volume to accommodate urine flow...
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28217123/virulence-markers-and-phylogenetic-analysis-of-escherichia-coli-strains-with-hybrid-eaec-upec-genotypes-recovered-from-sporadic-cases-of-extraintestinal-infections
#3
Flaviane B M Lara, Danielly R Nery, Pâmela M de Oliveira, Mayana L Araujo, Fabiana R Q Carvalho, Lorena C F Messias-Silva, Leonardo B Ferreira, Celio Faria-Junior, Alex L Pereira
Virulence genes from different E. coli pathotypes are blended in hybrid strains. E. coli strains with hybrid enteroaggregative/uropathogenic (EAEC/UPEC) genotypes have sporadically emerged causing outbreaks of extraintestinal infections, however their association with routine infections is yet underappreciated. We assessed 258 isolates of E. coli recovered from 86 consecutive cases of extraintestinal infections seeking EAEC and hybrid genotype (EAEC/UPEC) strains. Extensive virulence genotyping was carried out to detect 21 virulence genes, including molecular predictors of EAEC and UPEC strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28208853/genotypic-characterization-of-virulence-factors-in-escherichia-coli-isolated-from-patients-with-acute-cystitis-pyelonephritis-and-asymptomatic-bacteriuria
#4
Mohsen Tabasi, Mohammad Reza Asadi Karam, Mehri Habibi, Ehsan Mostafavi, Saeid Bouzari
INTRODUCTION: Urinary Tract Infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC) are among the most common infections worldwide. It is well-documented that the pathogenesis of UPEC is mediated by the production of a wide variety of Virulence Factors (VFs). Thus, detection of these VFs and evaluation of their association with different clinical types of UTIs could help to understand the role of these factors in pathogenesis of UPEC isolates. AIM: To investigate the genotypic characteristics of UPEC isolates and to examine the relationship between VFs and different clinical symptoms of UTI...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28142108/homeopathic-medicine-cantharis-modulates-uropathogenic-e-coli-upec-induced-cystitis-in-susceptible-mice
#5
Cidéli de Paula Coelho, Priscilla Dias Motta, Mariana Petrillo, Renata de Oliveira Iovine, Luciane Costa Dalboni, Fabiana Rodrigues Santana, Michelle Sanchez Freitas Correia, Renato Corrêa Viana Casarin, Vania Maria Carvalho, Leoni Villano Bonamin
OBJECTIVE: This is a random blinded placebo controlled murine experimental model to study the effects of Cantharis 6 CH, a homeopathic medicine, on E coli-induced cystitis. METHODS: 24 adult susceptible female BALB/c mice were inoculated with E coli - UPEC O4:K-:H5 by a transurethral catheter. Cantharis 6cH or vehicle (placebo) was offered to mice by free access into the drinking water (1:100), during 24 h after infection. Spleen, bladder and kidneys were processed for quantitative histopathology after immunohistochemistry, using anti-CD3, CD79, MIF, NK and VEGF antibodies; the cytokines present in the bladder washing fluid were measured using a LUMINEX-Magpix KIT...
January 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28141590/detection-of-virulence-genes-phylogenetic-group-and-antibiotic-resistance-of-uropathogenic-escherichia-coli-in-mongolia
#6
Yandag Munkhdelger, Nyamaa Gunregjav, Altantsetseg Dorjpurev, Nishi Juniichiro, Jav Sarantuya
INTRODUCTION: The severity of urinary tract infection (UTI) produced by uropathogenic Escherichia coli (UPEC) is due to the expression of a wide spectrum of virulence genes. E. coli strains were divided into four phylogenetic groups (A, B1, B2 and D) based on their virulence genes. The present study aimed to assess the relationship between virulence genes, phylogenetic groups, and antibiotic resistance of UPEC. METHODOLOGY: A total of 148 E. coli were tested for antimicrobial resistance against 10 drugs using the disk diffusion method...
January 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28122589/escherichia-coli-o78-isolated-from-septicemic-lambs-shows-high-pathogenicity-in-a-zebrafish-model
#7
Cecilie K Kjelstrup, Amelia E Barber, J Paul Norton, Matthew A Mulvey, Trine M L'Abée-Lund
The pathogenicity of Escherichia coli O78 strain K46, originally isolated from an outbreak of septicemia in neonatal lambs, was investigated in zebrafish embryo and murine models of infection. Its biofilm potential, cellulose production, and the expression of type 1 pili and curli fimbriae were measured by in vitro assays. The strain was highly pathogenic in the zebrafish embryo model of infection, where it killed all embryos within 24 h post inoculation (hpi) at doses as low as 1000 colony forming units. Zebrafish embryos inoculated with similar doses of commensal E...
January 25, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28119486/repeated-treatments-with-chitosan-in-combination-with-antibiotics-completely-eradicate-uropathogenic-escherichia-coli-from-infected-mouse-urinary-bladders
#8
Andreja Erman, Veronika Križan Hergouth, Matthew G Blango, Mojca Kerec Kos, Matthew A Mulvey, Peter Veranič
Uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tract infections, colonize and invade the epithelial cells of the bladder urothelium. Infection of immature urothelial cells can result in the formation of persistent intracellular reservoirs that are refractory to antibiotic treatments. Previously, we defined a novel therapeutic strategy utilizing the bladder cell exfoliant chitosan to deplete UPEC reservoirs. However, though a single treatment of chitosan followed by ciprofloxacin administration had a marked effect on reducing UPEC titers within the bladder, this treatment failed to prevent relapsing bacteriuria...
January 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28104383/virulence-traits-and-pathogenicity-of-uropathogenic-escherichia-coli-isolates-with-common-and-uncommon-o-serotypes
#9
Qingqing Gao, Debao Zhang, Zhengqin Ye, Xiaoping Zhu, Weixia Yang, Lanmei Dong, Song Gao, Xiufan Liu
Urinary tract infections (UTIs) are among the most common human diseases worldwide. This study aimed to collect uropathogenic Escherichia coli (UPEC) isolates from Jiangsu Province and obtain insights into the molecular epidemiology of UPEC in this region. The O serotypes, phylogenetic groups, and virulence factors of 183 UPEC isolates were determined. In this study, we isolated 51 UPEC isolates with common O serotypes including O1, O2, O4, O6, O7, O16, O18 and O75, as well as 35 of those with uncommonly encountered O serotypes including O8, O12, O15, O26, and O74...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28087472/extract-of-clinopodium-bolivianum-protects-against-e-coli-invasion-of-uroepithelial-cells
#10
Soumitra Mohanty, Witchuda Kamolvit, Silvia Zambrana, Corine Sandström, Eduardo Gonzales, Claes-Göran Östenson, Annelie Braunerf
ETHNOPHARMACOLOGICAL RELEVANCE: Clinopodium bolivianum is a South American plant with anti-inflammatory and anti-infective activities. The increasing antibiotic resistance urges for alternative therapy. Based on its use in traditional medicine, we investigated the effect of C. bolivianum on the ability to defend bladder epithelial cells from E. coli infection. MATERIALS AND METHODS: The extract was analysed by LC-MS. Bladder epithelial cell lines T24 and 5637 and uropathogenic E...
January 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28074004/signaling-by-two-component-system-noncognate-partners-promotes-intrinsic-tolerance-to-polymyxin-b-in-uropathogenic-escherichia-coli
#11
Kirsten R Guckes, Erin J Breland, Ellisa W Zhang, Sarah C Hanks, Navleen K Gill, Holly M S Algood, Jonathan E Schmitz, Charles W Stratton, Maria Hadjifrangiskou
Bacteria use two-component systems (TCSs) to react appropriately to environmental stimuli. Typical TCSs comprise a sensor histidine kinase that acts as a receptor coupled to a partner response regulator that coordinates changes in bacterial behavior, often through its activity as a transcriptional regulator. TCS interactions are typically confined to cognate pairs of histidine kinases and response regulators. We describe two distinct TCSs in uropathogenic Escherichia coli (UPEC) that interact to mediate a response to ferric iron...
January 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28063174/oral-supplementation-of-trans-cinnamaldehyde-reduces-uropathogenic-escherichia-coli-colonization-in-a-mouse-model
#12
A Narayanan, M S Muyyarikkandy, S Mooyottu, K Venkitanarayanan, M A R Amalaradjou
: Urinary tract infections (UTIs) in the United States result in more than 7 million hospital visits per year. Uropathogenic Escherichia coli (UPEC) is responsible for more than 80% of UTIs. Although antibiotics are the drug of choice to control UTIs, their repeated use has resulted in the emergence of antibiotic-resistant UPEC. Thus, there is a need for effective alternate strategies to control UPEC infections. This study investigated the efficacy of trans-cinnamaldehyde (TC), a food-grade molecule present in cinnamon, in reducing UPEC colonization and pathogenesis in the lower UTI...
January 7, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28040531/traditionally-used-medicinal-plants-against-uncomplicated-urinary-tract-infections-hexadecyl-coumaric-acid-ester-from-the-rhizomes-of-agropyron-repens-l-p-beauv-with-antiadhesive-activity-against-uropathogenic-e-coli
#13
Shabnam Sarshar Beydokthi, Jandirk Sendker, Simone Brandt, Andreas Hensel
The rhizomes from Agropyron repens are traditionally used for the treatment of uncomplicated urinary tract infections. Extracts prepared with solvents of different polarity did not show any cytotoxic effects against different strains of uropathogenic E. coli (UPEC) and human T24 bladder cells under in vitro conditions. Significant antiadhesive activity against the bacterial attachment to human T24 bladder cells was found for an acetone extract (AAE) at concentrations >250μg/mL. More hydrophilic extracts did not influence the bacterial attachment to the eukaryotic host cells...
December 29, 2016: Fitoterapia
https://www.readbyqxmd.com/read/28031261/copper-is-a-host-effector-mobilized-to-urine-during-urinary-tract-infection-to-impair-bacterial-colonization
#14
Amanda N Hyre, Kylie Kavanagh, Nancy D Kock, George L Donati, Sargurunathan Subashchandrabose
Urinary tract infection (UTI) is a major global infectious disease affecting millions of people annually. Human urinary copper (Cu) content is elevated during UTI caused by uropathogenic E. coli (UPEC). UPEC upregulate the expression of Cu efflux genes during clinical UTI in patients as an adaptive response to host-derived Cu. Whether Cu is mobilized to urine as a host response to UTI and its role in protection against UTI remain unresolved. To address these questions, we tested the hypothesis that Cu is a host effector mobilized to urine during UTI to limit bacterial growth...
December 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/28028717/multi-drug-resistant-uropathogenic-escherichia-coli-and-its-treatment-by-chinese-medicine
#15
Shi-Wei Liu, Xiao-Yang Xu, Jie Xu, Jiu-Yun Yuan, Wei-Kang Wu, Ning Zhang, Ze-Liang Chen
OBJECTIVES: To investigate the resistance and virulence profiles of uropathogenic Escherichia coli (UPEC) and its treatment by Chinese medicine (CM) Fuzheng Qingre Lishi Formula (, FQLF). METHODS: UPEC strains were isolated from recurrent urinary tract infections (UTIs) patients. Patient sensitivities to 17 antibiotics were tested by the disk diffusion method. Virulence genes were screened by plolymerase chain reaction. A mouse model was constructed using a multi-drug resistant and virulent UPEC strain and treated with FQLF or the antibiotic imipenem...
December 27, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27993701/comprehensive-expression-analysis-of-pathogenicity-genes-in-uropathogenic-escherichia-coli-strains
#16
Gloria Luz Paniagua-Contreras, Tania Hernández-Jaimes, Eric Monroy-Pérez, Felipe Vaca-Paniagua, Clara Díaz-Velásquez, Alina Uribe-García, Sergio Vaca
In this study, we investigated distinct expression patterns of genes encoding iron-acquisition systems, adhesins, protectins, and toxins in human uroepithelial cells infected with 194 uropathogenic Escherichia coli (UPEC) strains in vitro. We assessed the association of these genes with antibiotic resistance genes in this group of UPEC strains, previously characterised by polymerase chain reaction (PCR). Strains were isolated from patients with urinary tract infections (UTIs) from Unidad Médica Familiar de Salud Pública, located in Estado de México, México...
December 18, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27980776/macrophagic-control-of-the-response-to-uropathogenic-e-coli-infection-by-regulation-of-iron-retention-in-an-il-6-dependent-manner
#17
Nana Owusu-Boaitey, Kyle A Bauckman, Tingxuan Zhang, Indira U Mysorekar
INTRODUCTION: Uropathogenic Escherichia coli (UPEC), the causative agent of over 85% of urinary tract infections (UTIs), elaborate a number of siderophores to chelate iron from the host. On the other hand, the host immune imperative is to limit the availability of iron to the bacteria. Little is known regarding the mechanisms underlying this host-iron-UPEC interaction. Our objective was to determine whether macrophages, in response to UPEC infection, retain extracellular siderophore-bound and free iron, thus limiting the ability of UPEC to access iron...
December 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27934822/distribution-of-virulence-determinants-among-antimicrobial-resistant-and-antimicrobial-susceptible-escherichia-coli-implicated-in-urinary-tract-infections
#18
Sam Stephenson, P D Brown
INTRODUCTION: Uropathogenic Escherichia coli (UPEC) rely on the correlation of virulence expression with antimicrobial resistance to persist and cause severe urinary tract infections (UTIs). OBJECTIVES: We assessed the virulence pattern and prevalence among UPEC strains susceptible and resistant to multiple antimicrobial classes. METHODS: A total of 174 non-duplicate UPEC strains from patients with clinically significant UTIs were analysed for susceptibility to aminoglycoside, antifolate, cephalosporin, nitrofuran and quinolone antibiotics for the production of extended-spectrum β-lactamases and for the presence of six virulence determinants encoding adhesins (afimbrial, Type 1 fimbriae, P and S-fimbriae) and toxins (cytotoxic necrotising factor and haemolysin)...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27916544/characterization-of-escherichia-coli-causing-community-acquired-urinary-tract-infections-in-mexico-city
#19
Laura Belmont-Monroy, Rosa María Ribas-Aparicio, Armando Navarro-Ocaña, H Ángel Manjarrez-Hernández, Sandra Gavilanes-Parra, Gerardo Aparicio-Ozores, Patricia Isidra Cauich-Sánchez, Ulises Garza-Ramos, José Molina-López
The O25-ST131 clone was identified within 169 uropathogenic Escherichia coli (UPEC) strains. The 44.8% of the 29 O25-ST131 clones detected were positive to least to one extended-spectrum β-lactamase gene. The phylogroup D was mainly found. The O25-ST131 clone appeared to be associated with community-acquired UTI in Mexico City.
February 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27902433/escherichia-coli-clonal-group-a-among-uropathogenic-infections-in-mexico-city
#20
Angel Manjarrez-Hernandez, José Molina-López, Sandra Gavilanes-Parra, Rigoberto Hernandez-Castro
Escherichia coli clonal group A (CGA) causes urinary tract and other extra-intestinal infections in humans. CGA is an important cause of trimethoprim/sulfamethoxazole (SXT) resistance in extra-intestinal pathogens. We examined the extent to which resistance in this area is related to CGA dissemination of E. coli from urinary tract infections (UTIs) in Mexico City. The virulence backgrounds of the isolates were also characterized. In this study, the frequency of resistance to SXT used for UTI treatment was high (56-65 %), and CGA isolates accounted for 9 of the 78 SXT-resistant isolates (11...
December 2016: Journal of Medical Microbiology
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