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https://www.readbyqxmd.com/read/29452875/use-of-expanders-for-bowel-protection-in-pediatric-pelvic-tumor-radiation-therapy-15-years-of-tolerance-results
#1
Fernand Missohou
PURPOSE: Bowel is often the dose-limiting organ in curative pelvic irradiation because of radiation enteritis when dose exceeds 40 to 45 Gy. To limit radiation enteritis, a silicone tissue-expander prothesis (STEP) connected to a subcutaneous self-sealing valve was prospectively used in children undergoing pelvic or abdominal radiation therapy. This study reports the 15-year long-term outcomes of this prospective series. METHODS AND MATERIALS: Between 1987 and 2008, 29 children from 3 Paris institutions received pelvic radiation therapy after surgical placement of a STEP in the pelvis...
December 14, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29451701/phase-1b-study-of-pasireotide-everolimus-and-selective-internal-radioembolization-therapy-for-unresectable-neuroendocrine-tumors-with-hepatic-metastases
#2
Hyun S Kim, Walid L Shaib, Chao Zhang, Ganji Purnachandra Nagaraju, Christina Wu, Olatunji B Alese, Zhengjia Chen, Edith Brutcher, Meredith Renfroe, Bassel F El-Rayes
BACKGROUND: Neuroendocrine tumors (NETs) metastasize to the liver. Everolimus and selective internal radioembolization (SIRT) are approved treatments. Pasireotide is a somatostatin analogue with an affinity for somatostatin receptors 1, 2, 3, and 5. Everolimus and pasireotide may potentiate SIRT radiosensitization and inhibit rebound angiogenesis. This study evaluated the safety of pasireotide, everolimus, and SIRT. METHODS: This 3 + 3 phase 1 trial evaluated 3 dose levels of everolimus (2...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29441340/small-bowel-obstruction-from-distant-metastasis-of-primary-breast-cancer-a-case-report
#3
Seung Jae Oh, Seon Young Park, Ji Young Kim, Hyunee Yim, Yongsik Jung, Sae Hwan Han
Gastrointestinal (GI) tract metastasis of primary breast cancer is very rare. We present a patient with small bowel obstruction from distant metastasis of primary breast cancer. Each characteristic features of concern of GI tract distant metastasis from many pervious studies has been reported differently. We should remember that GI tract metastasis may coexist when patients with breast cancer have intermittent or recurrent abdominal pain with or without obstructive symptoms.
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29435757/defining-minimal-clearances-for-adequate-lymphatic-resection-relevant-to-right-colectomy-for-cancer-a-post-mortem-study
#4
Jens Marius Nesgaard, Bojan V Stimec, Pricilla Soulie, Bjørn Edwin, Arne Bakka, Dejan Ignjatovic
BACKGROUND: There has been a lengthy discussion on the extent of lymphatic resection for right-sided colon cancer and the central borders of the mesentery that are not yet defined. The objectives of this study are to define minimal clearances for adequate lymphatic resection in regard to colic artery origins and the superior mesenteric artery (SMA) and vein (SMV) relevant to right colectomy. METHODS: Central mesenteric lymph vessels, nodes, and blood vessels were dissected in 16 cadavers...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29434183/plasmacytoid-urothelial-carcinoma-of-ureter-with-retroperitoneal-metastasis-a-case-report
#5
Alexis Jibril, Andrew C Stevens
BACKGROUND Plasmacytoid is a rare histological variant of urothelial carcinoma (UC). Since the first reported case of plasmacytoid urothelial carcinoma (PUC), in 1991, only about 100 cases have since been reported, with most cases involving the bladder. Urothelial carcinomas of the upper urinary tract represent only 5% of urothelial cancers. To the best of our knowledge, there has only been 1 reported case of PUC of the ureter. PUC is a highly aggressive disease, with a poor prognosis. We present a rare biopsy-proven case of PUC of the ureter with retroperitoneal metastasis...
February 13, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29429965/mast-cells-promote-small-bowel-cancer-in-a-tumor-stage-specific-and-cytokine-dependent-manner
#6
Abdulrahman M Saadalla, Abu Osman, Michael F Gurish, Kristen L Dennis, Nichole R Blatner, Abdulmohammad Pezeshki, Kelly M McNagny, Hilde Cheroutre, Fotini Gounari, Khashayarsha Khazaie
Mast cells (MCs) are tissue resident sentinels that mature and orchestrate inflammation in response to infection and allergy. While they are also frequently observed in tumors, the contribution of MCs to carcinogenesis remains unclear. Here, we show that sequential oncogenic events in gut epithelia expand different types of MCs in a temporal-, spatial-, and cytokine-dependent manner. The first wave of MCs expands focally in benign adenomatous polyps, which have elevated levels of IL-10, IL-13, and IL-33, and are rich in type-2 innate lymphoid cells (ILC2s)...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29427732/risk-of-oral-and-upper-gastrointestinal-cancers-in-persons-with-positive-results-from-a-fecal-immunochemical-test-in-a-colorectal-cancer-screening-program
#7
Manon van der Vlugt, Esmée J Grobbee, Patrick M Bossuyt, Amanda C R K Bos, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: European guidelines recommend screening for colorectal cancer (CRC) using the fecal immunochemical test (FIT), with follow-up colonoscopies for individuals with positive test results. However, more than half of participants with positive results from the FIT are not found to have advanced neoplasia in the colonoscopy examination. Fecal occult blood might also come from the upper gastrointestinal (GI) tract, so perhaps we should consider esophagogastroduodenoscopy (EGD), to detect upper GI cancers...
February 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29413211/gastrointestinal-traumatic-injuries-gastrointestinal-perforation
#8
REVIEW
Maria A Revell, Marcia A Pugh, Melanie McGhee
The abdomen is a big place even in a small person. Gastrointestinal trauma can result in injury to the stomach, small bowel, colon, or rectum. Traumatic causes include blunt or penetrating trauma, such as gunshot wounds, stabbings, motor vehicle collisions, and crush injuries. Nontraumatic causes include appendicitis, Crohn disease, cancer, diverticulitis, ulcerative colitis, blockage of the bowel, and chemotherapy. The mechanism of injury will affect both the nature and severity of any resulting injuries. Treatment must address the critical and emergent nature of these injuries as well as issues that affect all trauma situations, which include management of hemodynamic instability...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29402880/adenocarcinoma-in-a-blind-loop-of-the-ileum-53-years-after-an-ileotransversostomy-procedure
#9
Ryohei Takei, Ichiro Onishi, Ryosuke Zaimoku, Naoki Makita, Yasumichi Yagi, Masato Kayahara
BACKGROUND Primary small bowel cancer is a rare malignancy; the common histopathological types are carcinoid and adenocarcinoma. Inflammatory bowel diseases and familial adenomatous polyposis are known risk factors for small bowel cancer. Additionally, cases of surgery-induced small bowel adenocarcinoma are sometimes reported after ileostomy. CASE REPORT A 84-year-old woman, who had undergone ileotransversostomy for intestinal obstruction due to postoperative adhesion following appendectomy at the age of 31 years, was referred to our hospital for further examination after experiencing abdominal pain in the right lower quadrant for 2 weeks...
February 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29402168/could-stool-collection-devices-help-increase-uptake-in-bowel-cancer-screening-programmes
#10
J R Morling, A N Barke, C J Chapman, R F Logan
Objective To understand the usage and acceptability of a faecal collection device amongst participants in the National Health Service Bowel Cancer Screening Programme, with the aim of influencing future uptake. Setting Participants completing faecal occult blood test retests as part of the routine Bowel Cancer Screening Programme in Eastern England. Methods A faecal collection device and questionnaire were sent to all potential retest participants during a one-month period to collect information on prior stool collection methods and ease of use and usefulness of the enclosed faecal collection device...
January 1, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29399614/high-complete-resection-rate-for-pre-lift-and-cold-biopsy-of-diminutive-colorectal-polyps
#11
Sam A O'Connor, Trevor N Brooklyn, Paul D Dunckley, Roland M Valori, Ruth Carr, Chris Foy, Thusitha Somarathna, Lukasz A Adamczyk, Neil A Shepherd, John T Anderson
Background and study aims:  The majority of polyps removed at colonoscopy are diminutive (≤ 5 mm) to small (< 10 mm) and there are few guidelines for the best way for these polyps to be removed. We aimed to assess the feasibility and effectiveness of cold biopsy forceps polypectomy with pre-lift (CBPP) for polyps ≤ 7 mm. Our aims were to assess completeness of histological resection of this technique, to identify factors contributing to this and assess secondary considerations such as timing, retrieval and complication rates...
February 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29398400/micrornas-link-chronic-inflammation-in-childhood-to-growth-impairment-and-insulin-resistance
#12
REVIEW
Francesca Cirillo, Pietro Lazzeroni, Cecilia Catellani, Chiara Sartori, Sergio Amarri, Maria Elisabeth Street
MicroRNAs are involved in multiple pathophysiological networks and in the pathogenesis of a broad spectrum of human disorders, including cancer and inflammatory diseases. Impaired linear growth is encountered in children with chronic inflammatory conditions such as cystic fibrosis, inflammatory bowel diseases, juvenile idiopathic arthritis, celiac disease and in subjects born intrauterine growth restricted/small for gestational age. Children with inflammatory conditions may also be at risk of developing insulin resistance as a result of the inflammatory process and concurrent therapy...
February 2, 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29394827/comprehensive-treatment-using-cytoreductive-surgery-combined-with-perioperative-chemotherapy-improved-outcome-of-colorectal-cancer-patients-with-metachronous-peritoneal-metastasis
#13
Yutaka Yonemura, Emel Canbay, Shouzou Sako, Satoshi Wakama, Haruaki Ishibashi, Masamitsu Hirano, Akiyoshi Mizumoto, Nobuyuki Takao, Masumi Ichinose, Kousuke Noguchi, Shunsuke Motoi, Yang Liu, Yan Li, Keizou Taniguchi
To analyze the role of cytoreductive surgery(CRS)plus perioperative chemotherapy on the survival of colorectal cancer(CRC)patients with metachronous peritoneal metastasis(PM). A comprehensive treatment consisting of neoadjuvant chemotherapy plus CRS was performed in 291 CRC patients. Among the 291, 142 and 149 patients had synchronous and metachronous PM, respectively. The results showed no survival difference between the 2 groups. Median survival time(MST)of patients with metachronous PM with complete cytoreduction(CCR-0), small bowel(SB)-PCIC2, PCIC14 and differentiated histologic type ranged from 3...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394790/-a-case-of-jejunal-ectopic-pancreatic-cancer-with-small-bowel-obstruction
#14
Norikazu Yogi, Takashi Kaiho, Shinji Yanagisawa, Masaaki Kataoka, Masaki Nishimura, Soichi Kobayashi, Akira Okaniwa, Ryuichiro Suda, Takuya Yoichi, Nobumitsu Shiina, Mitsuhiko Yoshida, Naoko Mise, Shunichi Tsuchiya
Were port a caseof an 82-year-old man who presented with vomiting. Computed tomography(CT)revealed a jejunum tumor and small bowel obstruction. Enteroscopy revealed a protruded lesion and biopsy indicated adenocarcinoma. PET-CT revealed nothing without jejunal tumor. Therefore, with a preoperative diagnosis of primary small bowel cancer, we performed operation. Surgery indicated peritoneal disseminations and a jejunal tumor 40 cm distal from the ligament of Treitz, and we performed small bowel partial resection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29388275/a-randomized-dose-response-trial-of-aerobic-exercise-and-health-related-quality-of-life-in-colon-cancer-survivors
#15
Justin C Brown, Nevena Damjanov, Kerry S Courneya, Andrea B Troxel, Babette S Zemel, Michael R Rickels, Bonnie Ky, Andrew D Rhim, Anil K Rustgi, Kathryn H Schmitz
OBJECTIVE: To examine the dose-response effects of aerobic exercise on health-related quality of life (HRQoL) among colon cancer survivors. METHODS: Thirty-nine stage I-III colon cancer survivors were randomized to one of three groups: usual-care control, 150 min·wk-1 of aerobic exercise (low-dose), and 300 min·wk-1 of aerobic exercise (high-dose) for six months. HRQoL outcomes included the Short Form (SF)-36 physical and mental component summary, Functional Assessment of Cancer Therapy-Colorectal (FACT-C), Pittsburgh Sleep Quality Index (PSQI), Fear of Cancer Recurrence Inventory (FCRI), Fatigue Symptom Inventory (FSI), and North Central Cancer Treatment Group bowel function questionnaire, assessed at baseline and post intervention...
February 1, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29383159/role-of-ddx3-in-the-pathogenesis-of-inflammatory-bowel-disease
#16
Saritha Tantravedi, Farhad Vesuna, Paul T Winnard, Marise R Heerma Van Voss, Paul J Van Diest, Venu Raman
When crypt stem cells of the gastrointestinal tract become injured, the result is increased synthesis of pro-inflammatory cytokines and matrix metalloproteinases by their progeny - the colonic epithelium. Chronic inflammation of the gastrointestinal tract is a characteristic of inflammatory bowel disease, which includes Crohn's Disease and Ulcerative Colitis. In our ongoing investigation to decipher the characteristic functions of a RNA helicase gene, DDX3, we identified high DDX3 expression by immunohistochemistry of colon biopsy samples, which included chronic/mild Morbus Crohn, active Morbus Crohn, Chronic/mild Colitis Ulcerosa and active Colitis Ulcerosa in epithelium and stromal compartments...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382460/management-of-iatrogenic-urorectal-fistulae-in-men-with-pelvic-cancer
#17
Francisco E Martins, Natália M Martins, Luís Campos Pinheiro, Luís Ferraz, Luís Xambre, Tomé M Lopes
INTRODUCTION: Urorectal fistula (URF) is a devastating complication of pelvic cancer treatments and a surgical challenge for the reconstructive surgeon. We report a series of male patients with URF resulting from pelvic cancer treatments, specifically prostate (PCa), bladder (BCa), and rectal cancer (RCa), and explore the differences and impact on outcomes between purely surgical and non-surgical treatment modalities. METHODS: Between October 2008 and June 2015, 15 male patients, aged 59-78 years (mean 67), with URF induced by pelvic cancer treatments were identified in our institutions...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29381126/the-evolving-management-of-small-bowel-adenocarcinoma
#18
Eelco de Bree, Koen P Rovers, Dimitris Stamatiou, John Souglakos, Dimosthenis Michelakis, Ignace H de Hingh
BACKGROUND: Small bowel adenocarcinoma (SBA) is rare despite the fact that the small bowel represents the longest part and has the largest surface of all alimentary tract sections. Its incidence is 50-fold lower than that of colorectal carcinoma. It is often diagnosed at an advanced stage due to atypical and late symptoms, its low index of suspicion, difficult endoscopic access and poor detection by radiological imaging, resulting in impaired outcome. Due to its rarity and being molecularly a unique intestinal cancer, data regarding its optimal management are relatively sparse...
January 30, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29379738/management-of-advanced-adenocarcinoma-in-indiana-pouch-urinary-diversion
#19
Michael A Bell, Edward J Wright, Sandy H Fang, Michael H Johnson, Nikolai A Sopko
Adenocarcinoma is a rare finding following urinary diversion with gastrointestinal segments. This report describes an 80-year-old woman with a history of bladder cancer who subsequently developed a pT4 adenocarcinoma 8 years following her radical cystectomy and Indiana Pouch continent urinary diversion. An en bloc resection of the pouch and affected small bowel was performed and the patient underwent conversion to an ileal conduit diversion. We use this case to highlight a mechanism for possible pathogenesis and the management of adenocarcinoma in urinary diversions including the need for regular surveillance and the surgical approach...
March 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29377871/symptom-severity-and-quality-of-life-among-long-term-colorectal-cancer-survivors-compared-with-matched-control-subjects-a-population-based-study
#20
Tae L Hart, Susan T Charles, Mekhala Gunaratne, Nancy N Baxter, Michelle Cotterchio, Zane Cohen, Steven Gallinger
BACKGROUND: Data are lacking regarding physical functioning, psychological well-being, and quality of life among colorectal cancer survivors >10 years postdiagnosis. OBJECTIVE: The purpose of this study was to examine self-reported physical functioning, quality of life, and psychological well-being in long-term colorectal cancer survivors compared with age- and sex-matched unaffected control subjects. DESIGN: Participants completed a cross-sectional survey...
March 2018: Diseases of the Colon and Rectum
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