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https://www.readbyqxmd.com/read/27935768/hypertrophic-osteoarthropathy-clinical-and-imaging-features
#1
Felix Y Yap, Matthew R Skalski, Dakshesh B Patel, Aaron J Schein, Eric A White, Anderanik Tomasian, Sulabha Masih, George R Matcuk
Hypertrophic osteoarthropathy (HOA) is a medical condition characterized by abnormal proliferation of skin and periosteal tissues involving the extremities and characterized by three clinical features: digital clubbing (also termed Hippocratic fingers), periostosis of tubular bones, and synovial effusions. HOA can be a primary entity, known as pachydermoperiostosis, or can be secondary to extraskeletal conditions, with different prognoses and management implications for each. There is a high association between secondary HOA and malignancy, especially non-small cell lung cancer...
December 9, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27922979/a-comparison-of-thermal-plasma-energy-versus-argon-beam-coagulator-induced-intestinal-injury-after-vaporization-in-a-porcine-model
#2
Edward J Tanner, Erica Dun, Yukio Sonoda, Alexander B Olawaiye, Dennis S Chi
OBJECTIVES: Complete cytoreduction of ovarian cancer often requires excision or ablation of bowel serosa implants. Both argon beam coagulator (ABC) and thermal plasma energy (TPE) (PlasmaJet; PlasmaSurgical, Roswell, Ga) have been used to ablate bowel serosa implants. Our objective was to identify comparable power settings as well as determine the rate of bowel perforation, depth of thermal injury, and extent of inflammatory response with ABC versus TPE in a porcine model. MATERIALS AND METHODS: Nine pigs underwent vaporization of small bowel and colon serosa according to assigned treatment group (TPE vs ABC) and settings (ABC: 30, 50, and 70 W; TPE: Cut 10U, 20U, and 30U and Coagulation 10U, 20U, and 30U)...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27913273/the-endocrine-vitamin-d-system-in-the-gut
#3
Antonio Barbáchano, Asunción Fernández-Barral, Gemma Ferrer-Mayorga, Alba Costales-Carrera, María Jesús Larriba, Alberto Muñoz
The active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) has important regulatory actions in the gut through endocrine and probably also intracrine, autocrine and paracrine mechanisms. By activating the vitamin D receptor (VDR), which is expressed at a high level in the small intestine and colon, 1,25(OH)2D3 regulates numerous genes that control gut physiology and homeostasis. 1,25(OH)2D3 is a major responsible for epithelial barrier function and calcium and phosphate absorption, and the host's defense against pathogens and the inflammatory response by several types of secretory and immune cells...
November 29, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27903746/intestinal-glycolysis-visualized-by-fdg-pet-ct-correlates-with-glucose-decrement-after-gastrectomy
#4
Cheol Ryong Ku, Narae Lee, Jae Won Hong, In Gyu Kwon, Woo Jin Hyung, Sung Hoon Noh, Eun Jig Lee, Mijin Yun, Arthur Cho
Gastrectomy method is known to influence glucose homeostasis. (18)F-fluorodeoxyglucose (FDG) PET/CT acquired after gastrectomy often reveals newly developed physiologic small bowel uptake. We correlated newly developed small bowel FDG uptake and glucose homeostasis in post-gastrectomy gastric cancer patients. We retrospectively analyzed 239 non-diabetic patients who underwent staging and follow-up FDG PET/CT before and after gastrectomy for gastric cancer. Post-operative small bowel glycolysis was quantified by recording intestinal total lesion glycolysis (TLG)...
November 30, 2016: Diabetes
https://www.readbyqxmd.com/read/27893174/is-there-a-relationship-between-objectively-measured-cognitive-changes-in-patients-with-solid-tumours-undergoing-chemotherapy-treatment-and-their-health-related-quality-of-life-outcomes-a-systematic-review
#5
REVIEW
Marie-Rose Dwek, Lorna Rixon, Catherine Hurt, Alice Simon, Stanton Newman
OBJECTIVE: This systematic review examines whether there is a relationship between objective measures of chemotherapy-related cognitive impairment in patients with solid cancer tumours and health related quality of life (HRQoL). METHODS: Multiple online databases were searched (including Ovid MEDLINE, EMBASE, PsycINFO, PsycARTICLES, CINAHL, PubMed and Web of Science) in order to identify articles published between 1980 and 2016 examining the extent of chemotherapy-related cognitive deficit and its relationship with HRQoL in cancer patients...
November 28, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27885681/dynamics-of-occurrence-of-refractory-coeliac-disease-and-associated-complications-over-25%C3%A2-years
#6
W Eigner, K Bashir, C Primas, L Kazemi-Shirazi, F Wrba, M Trauner, H Vogelsang
BACKGROUND: Refractory coeliac disease, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma are rare but prognostically important complications in coeliac disease. AIM: To analyse potential changes in occurrence of complicated coeliac disease over the last 25 years. METHODS: One thousand one hundred and thirty eight patients were included and evaluated based on their time of first presentation at the Medical University of Vienna, Austria...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27875518/a-national-cluster-randomised-controlled-trial-to-examine-the-effect-of-enhanced-reminders-on-the-socioeconomic-gradient-in-uptake-in-bowel-cancer-screening
#7
Rosalind Raine, Sue M Moss, Christian von Wagner, Wendy Atkin, Ines Kralj Hans, Rosemary Howe, Francesca Solmi, Stephen Morris, Nicholas Counsell, Allan Hackshaw, Stephen Halloran, Graham Handley, Richard F Logan, Sandra Rainbow, Steve Smith, Julia Snowball, Helen Seaman, Mary Thomas, Samuel G Smith, Lesley M McGregor, Gemma Vart, Jane Wardle, Stephen W Duffy
BACKGROUND: The NHS Bowel Cancer Screening Programme in England offers biennial guaiac faecal occult blood testing (gFOBt). There is a socioeconomic gradient in participation and socioeconomically disadvantaged groups have worse colorectal cancer survival than more advantaged groups. We compared the effectiveness and cost of an enhanced reminder letter with the usual reminder letter on overall uptake of gFOBt and the socioeconomic gradient in uptake. METHODS: We enhanced the usual reminder by including a heading 'A reminder to you' and a short paragraph restating the offer of screening in simple language...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27873087/key-questions-for-translation-of-ffa-receptors-from-pharmacology-to-medicines
#8
Arthur T Suckow, Celia P Briscoe
The identification of fatty acids as ligands for the G-protein coupled free fatty acid (FFA) receptor family over 10 years ago led to intensive chemistry efforts to find small-molecule ligands for this class of receptors. Identification of potent, selective modulators of the FFA receptors and their utility in medicine has proven challenging, in part due to their complex pharmacology. Nevertheless, ligands have been identified that are sufficient for exploring the therapeutic potential of this class of receptors in rodents and, in the case of FFA1, FFA2, FFA4, and GPR84, also in humans...
November 22, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27859010/bevacizumab-combined-with-capecitabine-and-oxaliplatin-in-patients-with-advanced-adenocarcinoma-of-the-small-bowel-or-ampulla-of-vater-a-single-center-open-label-phase-2-study
#9
Pat Gulhati, Kanwal Raghav, Rachna T Shroff, Gauri R Varadhachary, Scott Kopetz, Milind Javle, Wei Qiao, Huamin Wang, Jeffrey Morris, Robert A Wolff, Michael J Overman
BACKGROUND: Capecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX. METHODS: In this phase 2, single-arm, single-center, open-label study, patients aged ≥18 years with untreated, advanced SBA or AAC were recruited. Patients received capecitabine at a dose of 750 mg/m(2) orally twice daily on days 1 to 14, oxaliplatin at a dose of 130 mg/m(2) intravenously on day 1, and bevacizumab at a dose of 7...
November 14, 2016: Cancer
https://www.readbyqxmd.com/read/27833393/safety-and-efficacy-of-self-expandable-metallic-stents-in-malignant-small-bowel-obstructions
#10
Akiyoshi Tsuboi, Toshio Kuwai, Tomoyuki Nishimura, Sumio Iio, Takeshi Mori, Hiroki Imagawa, Toshiki Yamaguchi, Atsushi Yamaguchi, Hirotaka Kouno, Hiroshi Kohno
In this report, we present 3 cases of malignant small bowel obstruction, treated with palliative care using endoscopic self-expandable metallic stent (SEMS) placement, with the aim to identify the safety and efficacy of this procedure. Baseline patient characteristics, procedure methods, procedure time, technical and clinical success rates, complications, and patient outcomes were obtained. All 3 patients had pancreatic cancer with small bowel strictures. One patient received the SEMS using colonoscopy, while the other 2 patients received SEMS placement via double balloon endoscopy using the through-the-overtube technique...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27833380/indications-and-surgical-options-for-small-bowel-large-bowel-and-perianal-crohn-s-disease
#11
REVIEW
James Wt Toh, Peter Stewart, Matthew Jfx Rickard, Rupert Leong, Nelson Wang, Christopher J Young
Despite advancements in medical therapy of Crohn's disease (CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27831706/the-psychological-challenges-of-living-with-an-ileostomy-an-interpretative-phenomenological-analysis
#12
Jonathan A Smith, Johanna Spiers, Phillip Simpson, Adam R Nicholls
Objectives: Ileostomy, in which the small intestine is redirected out of an abdominal wall so that waste is collected using a bag, is used to treat conditions including inflammatory bowel disease and colorectal cancer. This article reports an in-depth idiographic analysis of the experience of living with an ileostomy. Method: Twenty-one participants took part in semistructured interviews about their lives and relationships. Those interviews were transcribed verbatim and analyzed using the experiential qualitative methodology interpretative phenomenological analysis...
November 10, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27829602/a-case-of-crohn-s-disease-complicated-with-simultaneous-double-cancers-of-the-small-bowel
#13
Nao Obara, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Hirosuke Kuroki, Kyoko Yamada, Katsuhiko Arai, Akira Sugita, Hiroyuki Hayashi, Tsuneo Fukushima
A case of Crohn's disease complicated with simultaneous double cancers of the small bowel is reported. The patient is a 66-year-old man who had suffered from Crohn's disease for 20 years. He underwent surgery to identify the source of repeated episodes of intestinal obstruction. Two short segments of strictures and proximal dilatations were found in the distal ileum. Therefore, we performed an en bloc resection of the two stenotic sections instead of strictureplasty. Histological examination of the resected specimen revealed not only Crohn's disease but also a well-differentiated adenocarcinoma within each of the two strictures...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27827303/an-hdac6-inhibitor-confers-protection-and-selectively-inhibits-b-cell-infiltration-in-dss-induced-colitis-in-mice
#14
Anh Do, Robert C Reid, Rink-Jan Lohman, Matthew J Sweet, David P Fairlie, Abishek Iyer
Small molecule histone deacetylase (HDAC) inhibitors with anti-inflammatory activity may be candidates for targeting intestinal inflammatory pathways in inflammatory bowel disease (IBD). This study investigated whether treatment with a potent HDAC6 inhibitor, BML-281, could protect against colonic inflammation and prevent inflammatory cell infiltration into the colon to drive disease pathology in a mouse model of acute DSS-colitis. Control and acute DSS-colitis mice were treated with BML-281 (1mg/kg/day s.c...
November 8, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27816300/racial-variation-in-patient-reported-outcomes-following-treatment-for-localized-prostate-cancer-results-from-the-ceasar-study
#15
Mark D Tyson, JoAnn Alvarez, Tatsuki Koyama, Karen E Hoffman, Matthew J Resnick, Xiao-Cheng Wu, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Lisa E Paddock, Antoinette Stroup, Vivien W Chen, David F Penson, Daniel A Barocas
BACKGROUND: Relatively little is known about the relationship between race/ethnicity and patient-reported outcomes after contemporary treatments for localized prostate cancer. OBJECTIVE: To test the hypothesis that treatment-related changes in urinary, bowel, sexual, and hormonal function vary by race/ethnicity. DESIGN, SETTING, AND PARTICIPANTS: The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled 3708 men diagnosed with localized prostate cancer in 2011-2012...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27811856/predictive-factors-of-antiproliferative-activity-of-octreotide-lar-as-first-line-therapy-for-advanced-neuroendocrine-tumours
#16
Faidon-Marios Laskaratos, Martin Walker, Keval Naik, Emmanouil Maragkoudakis, Nikolaos Oikonomopoulos, Lee Grant, Tim Meyer, Martyn Caplin, Christos Toumpanakis
BACKGROUND: The antiproliferative activity of octreotide LAR in neuroendocrine tumours (NETs) has been demonstrated by small retrospective studies and confirmed by a prospective phase III trial (PROMID). However, there are limited data about the duration and predictors of response. The aim of our retrospective study was to determine the time to radiological progression (TTRP) of disease and the factors that were associated with better response. METHODS: A total of 254 treatment naïve patients with advanced NETs and positive somatostatin receptor scintigraphy were included...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27790115/diagnosis-of-jejunal-metastases-from-lung-cancer-using-capsule-endoscopy
#17
Charlotte Leduc, Nathalie Prim, Bertrand Mennecier, Michel Delvaux, Afshin Gangi, Elisabeth Quoix
Gastrointestinal metastases from lung cancer are rare and usually asymptomatic. We report a case of small bowel metastases from primary lung cancer revealed by abdominal pain and severe recurrent anaemia. The diagnosis was obtained with capsule endoscopy. This non-invasive procedure thus represents a valuable method contributing to a rapid and detailed diagnosis while reducing underdiagnosis, and it should thus be considered for lung cancer patients complaining of abdominal symptoms, which may indeed be related to gastrointestinal metastases...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27785689/complications-of-feeding-jejunostomy-tubes-in-patients-with-gastroesophageal-cancer
#18
Audrey H Choi, Michael P O'Leary, Shaila J Merchant, Virginia Sun, Joseph Chao, Dan J Raz, Jae Y Kim, Joseph Kim
BACKGROUND: Feeding jejunostomy tubes (FJT) in patients undergoing resection of gastroesophageal cancers facilitate perioperative nutrition. Data regarding FJT use and complications are limited. STUDY DESIGN: A single institution review was performed for patients who underwent perioperative FJT placement for gastrectomy or esophagogastrectomy from 2007 to 2015. FJT-related and unrelated complications were evaluated. RESULTS: FJTs were inserted for total/completion gastrectomy (n = 49/117, 41...
October 26, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27784975/limited-local-extracolonic-spread-of-mucinous-appendiceal-adenocarcinoma-after-perforation-with-formation-of-a-malignant-appendix-to-sigmoid-fistula-case-report-and-literature-review
#19
Seifeldin Hakim, Mitual Amin, Mitchell S Cappell
A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum (with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27783343/outcomes-after-surgery-for-benign-and-malignant-small-bowel-obstruction
#20
Lauren M Wancata, Zaid M Abdelsattar, Pasithorn A Suwanabol, Darrell A Campbell, Samantha Hendren
BACKGROUND: Small bowel obstruction (SBO) is a common diagnosis; however, outcomes of and risk factors for SBO and malignant bowel obstruction (MBO) surgery are not well understood. We sought to characterize outcomes and risk factors for surgery for SBO and MBO. METHODS: A retrospective cohort study was performed utilizing prospectively collected data from the Michigan Surgical Quality Collaborative (7/2012-3/2015). Cases included those with ICD9 diagnosis code of bowel obstruction and CPT codes for lysis of adhesions, intestinal bypass, and small bowel resection...
October 25, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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