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https://www.readbyqxmd.com/read/28819895/optimal-lymphadenectomy-in-small-bowel-neuroendocrine-tumors-analysis-of-the-ncdb
#1
Benjamin M Motz, Patrick D Lorimer, Danielle Boselli, Joshua S Hill, Jonathan C Salo
BACKGROUND: Current National Comprehensive Cancer Network guidelines for resectable small bowel neuroendocrine tumors (NETs) recommend regional lymphadenectomy. However, no consensus exists on the optimal nodal harvest. METHODS: The National Cancer Database was queried for patients with resectable small bowel NETs (1998-2013). Patients with metastatic disease and missing lymph node harvest data were excluded. We performed logistic regression of factors determining nodal positivity and multivariable survival analyses...
August 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28819783/factors-associated-with-hospital-readmission-following-diverting-ileostomy-creation
#2
W Li, L Stocchi, D Cherla, G Liu, A Agostinelli, C P Delaney, S R Steele, E Gorgun
BACKGROUND: The creation of a diverting loop ileostomy is associated with the risk of readmission due to stoma-related complications. We hypothesized that the assessment of our institution-specific readmissions following ileostomy creation would help identifying at-risk groups which should be the focus of future preventative strategies. METHODS: Patients who underwent loop ileostomy formation from 2009 to 2013 were reviewed. We evaluated readmissions within 30 days after discharge following loop ileostomy construction...
August 17, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28818187/ileus-in-adults
#3
Tim O Vilz, Burkhard Stoffels, Christian Strassburg, Hans H Schild, Jörg C Kalff
BACKGROUND: Ileus is one of the more common suspected diagnoses in everyday clinical practice. The term can refer either to mechanical or to functional ileus. Any physician who takes care of patients can be confronted with these entities; thus, all should be familiar with them and competent in their management. METHODS: Recommendations are summarized for the diagnostic evaluation and treatment of ileus of various causes on the basis of a selective literature review...
July 24, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28807841/racial-disparity-in-gastrointestinal-cancer-risk
#4
REVIEW
Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers
Cancer from the gastrointestinal tract and its associated excretory organs will occur in over 300,000 Americans in 2017, with colorectal cancer responsible for over forty percent of that burden; there will be over 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to these cancers' incidence and mortality exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in Non-Hispanic Whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among Blacks...
August 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28807748/dosimetric-analysis-and-preliminary-clinical-result-of-image-guided-brachytherapy-with-or-without-hybrid-technique-for-cervical-cancer-using-varisource-titanium-ring-applicator-with-siriraj-ring-cap
#5
Pittaya Dankulchai, Suphalerk Lohasammakul, Janjira Petsuksiri, Pitchayut Nakkrasae, Lalida Tuntipumiamorn, Chumpot Kakanaporn, Yaowalak Chansilpa
PURPOSE: Titanium ring cap applicator (VariSource) was applied in treating cervical cancer patients by using image-guided brachytherapy (IGBT). However, its sizes appeared to be relatively large for most of our patients. Thus, we have developed a specific applicator "Siriraj Ring Cap," which is slightly smaller and more suitable for our patients. This study was to evaluate effectiveness of this equipment. METHODS AND MATERIALS: Locally advanced cervical cancer patients were treated with external beam radiation therapy with or without concomitant chemotherapy...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28802831/validation-of-a-targeted-rna-sequencing-assay-for-kinase-fusion-detection-in-solid-tumors
#6
Julie W Reeser, Dorrelyn Martin, Jharna Miya, Esko A Kautto, Ezra Lyon, Eliot Zhu, Michele R Wing, Amy Smith, Matthew Reeder, Eric Samorodnitsky, Hannah Parks, Karan R Naik, Joseph Gozgit, Nicholas Nowacki, Kurtis D Davies, Marileila Varella-Garcia, Lianbo Yu, Aharon G Freud, Joshua Coleman, Dara L Aisner, Sameek Roychowdhury
Kinase gene fusions are important drivers of oncogenic transformation and can be inhibited with targeted therapies. Clinical grade diagnostics using RNA sequencing to detect gene rearrangements in solid tumors are limited, and the few that are available require prior knowledge of fusion break points. To address this, we have analytically validated a targeted RNA sequencing assay (OSU-SpARKFuse) for fusion detection that interrogates complete transcripts from 93 kinase and transcription factor genes. From a total of 74 positive and 36 negative control samples, OSU-SpARKFuse had 93...
August 8, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28799796/immune-modulation-by-curcumin-the-role-of-interleukin-10
#7
Hamid Mollazadeh, Arrigo F G Cicero, Christopher N Blesso, Matteo Pirro, Muhammed Majeed, Amirhossein Sahebkar
Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8(+) T cells, and TH1, TH2, and TH17 and regulatory T cells...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28767610/clinicopathological-features-surgical-treatments-and-survival-outcomes-of-patients-with-small-bowel-adenocarcinoma
#8
Shuisheng Zhang, Wei Yuan, Jianwei Zhang, Yingtai Chen, Cuiling Zheng, Jie Ma, Qinglong Jiang, Yajie Zhao, Quan Xu, Chengfeng Wang
To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) examined patients with SBA treated surgically at the China National Cancer Center/Cancer Hospital. Clinicopathological features, preoperative evaluation, surgical treatment, and outcome parameters were reviewed and analyzed...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28765854/psa-testing-for-men-at-average-risk-of-prostate-cancer
#9
Bruce K Armstrong, Michael J Barry, Mark Frydenberg, Robert A Gardiner, Ian Haines, Stacy M Carter
Prostate-specific antigen (PSA) testing of men at normal risk of prostate cancer is one of the most contested issues in cancer screening. There is no formal screening program, but testing is common - arguably a practice that ran ahead of the evidence. Public and professional communication about PSA screening has been highly varied and potentially confusing for practitioners and patients alike. There has been much research and policy activity relating to PSA testing in recent years. Landmark randomised controlled trials have been reported; authorities - including the 2013 Prostate Cancer World Congress, the Prostate Cancer Foundation of Australia, Cancer Council Australia, and the National Health and Medical Research Council - have made or endorsed public statements and/or issued clinical practice guidelines; and the US Preventive Services Task Force is revising its recommendations...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28760506/a-comparison-of-treatment-plan-quality-between-tri-co-60-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy-for-cervical-cancer
#10
Jong Min Park, So-Yeon Park, Jung-In Kim, Hyun-Cheol Kang, Chang Heon Choi
PURPOSE: To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) for cervical cancer. METHODS: A total of 20 patients who received postoperative radiotherapy for cervical cancer were selected. For each patient, a tri-Co-60 IMRT plan for which the target volume was the planning target volume (PTV) generated by adding 1mm isotropic margins from the clinical target volume (CTV) and a VMAT plan for which the target volume was the PTV generated by adding 7mm and 10mm margins from the CTV were generated...
July 28, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28757301/quality-of-life-outcomes-after-primary-treatment-for-clinically-localised-prostate-cancer-a-systematic-review
#11
REVIEW
Michael Lardas, Matthew Liew, Roderick C van den Bergh, Maria De Santis, Joaquim Bellmunt, Thomas Van den Broeck, Philip Cornford, Marcus G Cumberbatch, Nicola Fossati, Tobias Gross, Ann M Henry, Michel Bolla, Erik Briers, Steven Joniau, Thomas B Lam, Malcolm D Mason, Nicolas Mottet, Henk G van der Poel, Olivier Rouvière, Ivo G Schoots, Thomas Wiegel, Peter-Paul M Willemse, Cathy Yuhong Yuan, Liam Bourke
CONTEXT: Current evidence-based management for clinically localised prostate cancer includes active surveillance, surgery, external beam radiotherapy (EBRT) and brachytherapy. The impact of these treatment modalities on quality of life (QoL) is uncertain. OBJECTIVE: To systematically review comparative studies investigating disease-specific QoL outcomes as assessed by validated cancer-specific patient-reported outcome measures with at least 1 yr of follow-up after primary treatment for clinically localised prostate cancer...
July 27, 2017: European Urology
https://www.readbyqxmd.com/read/28748420/risk-factors-for-early-postoperative-small-bowel-obstruction-after-anterior-resection-for-rectal-cancer
#12
Katsuhito Suwa, Takuro Ushigome, Masamichi Ohtsu, Satoshi Narihiro, Shunjin Ryu, Yuya Shimoyama, Tomoyoshi Okamoto, Katsuhiko Yanaga
PURPOSE: The aim of the study was to evaluate risk factors for small bowel obstruction (SBO) in early postoperative period after anterior resection for rectal cancer. METHODS: Patients who underwent anterior resection (AR) [high AR (HAR) or low AR (LAR)] for rectal cancer between January 2009 and April 2016 were enrolled into the study after fulfilling selection criteria. In included patients, risk factors for early postoperative SBO (EPSBO) were analyzed by means of univariate and multivariate analysis...
July 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28743097/less-is-more-an-outcome-assessment-of-patients-operated-for-gallstone-ileus-without-fistula-treatment
#13
Dario Tartaglia, Sohail Bakkar, Lorenzo Piccini, Jessica Bronzoni, Luigi Cobuccio, Andrea Bertolucci, Christian Galatioto, Massimo Chiarugi
BACKGROUND: The treatment of gallstone ileus (GI) consists of surgical removal of the impacted bilestone with or without cholecystectomy and repair of the biliodigestive fistula. The objective of this study was to assess whether sparing patients a definitive biliary procedure adversely influenced the outcome. MATERIALS AND METHODS: Patients with a diagnosis of GI were reviewed. Two groups were identified: patients who underwent a definitive biliary procedure with relieving the intestinal obstruction (group 1/G1) and those who did not have a definitive biliary procedure (group 2/G2)...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28741494/evolutionary-ecology-of-organs-a-missing-link-in-cancer-development
#14
REVIEW
Frédéric Thomas, Randolph M Nesse, Robert Gatenby, Cindy Gidoin, François Renaud, Benjamin Roche, Beata Ujvari
There is striking variation in the incidence of cancer in human organs. Malignant tumors are common in the colon and breast but rare in the heart and small bowel. The uterus frequently develops benign fibroid tumors but uterine cancers are relatively rare. The organ-specific difference in cancer prevalence has been explained primarily by the relative roles of intrinsic and extrinsic risk factors. In this opinion article, we propose also considering organs as distinct but connected ecosystems whose different vulnerabilities to malignant transformation may be partially explained by how essential each organ is for survival through the age of reproduction...
August 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28738955/primary-site-predicts-grade-for-gastroenteropancreatic-neuroendocrine-tumors
#15
Timothy L Fitzgerald, Catalina Mosquera, C Suzanne Lea, Matthew McMullen
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and abstruse neoplasms with increasing incidence and clinical relevance. The National Cancer Data Base was examined to identify GEP-NET cases from 2004 to 2013. In total, 39,454 patients diagnosed with GEP-NET were identified. Median age was 61 years. Majority was female (50.13%), white (79.49%), and had low-grade neoplasms (84.39%). On univariate analysis, age, sex, race, primary site, tumor size, and regional lymph node involvement were associated with tumor grade (P < 0...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28720378/a-novel-technique-carbon-dioxide-gas-assisted-total-peritonectomy-diaphragm-and-intestinal-meso-stripping-in-open-surgery-for-advanced-ovarian-cancer-%C3%A3-ukurova-technique
#16
Ghanim Khatib, Ahmet Baris Guzel, Umran Kucukgoz Gulec, Mehmet Ali Vardar
OBJECTIVE: Most of the ovarian cancers are diagnosed at advanced stages. As peritoneal carcinomatosis increases, especially when it extends to the diaphragm and intestinal mesos, probability of obtaining complete cytoreduction is reduced. Complete cytoreduction (residue zero: R0) is one of the main factors affecting survival [1-3]. Here we present a novel technique of stripping the peritoneal surfaces as a part of cytoreductive surgery in such cases. METHODS: A 55year-old woman diagnosed with peritoneal carcinomatosis was considered appropriate for primary cytoreduction after assessment of her thorax-abdominopelvic tomography, which revealed resectable intra-abdominal disease...
July 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28720359/functional-outcomes-following-radical-cystectomy-in-women-with-bladder-cancer-a-systematic-review
#17
REVIEW
Angela B Smith, Karen Crowell, Michael E Woods, Eric M Wallen, Raj S Pruthi, Matthew E Nielsen, Cheryl T Lee
CONTEXT: Gender-specific functional and health-related quality of life (HRQOL) outcomes following radical cystectomy (RC) for bladder cancer (BCa) remain unclear, with many studies excluding women from the study population. OBJECTIVE: To better characterize female-specific functional outcomes following RC and urinary diversion for BCa. EVIDENCE ACQUISITION: We performed a critical review of PubMed/Medline and Embase in August 2015 according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28717395/brain-imaging-before-primary-lung-cancer-resection-a-controversial-topic
#18
Zoe Hudson, Eveline Internullo, Anthony Edey, Isabel Laurence, Davide Bianchi, Alfredo Addeo
OBJECTIVE: International and national recommendations for brain imaging in patients planned to undergo potentially curative resection of non-small-cell lung cancer (NSCLC) are variably implemented throughout the United Kingdom [Hudson BJ, Crawford MB, and Curtin J et al (2015) Brain imaging in lung cancer patients without symptoms of brain metastases: a national survey of current practice in EnglandClin Radiol https://doi.org/10.1016/j.crad.2015.02.007]. However, the recommendations are not based on high-quality evidence and do not take into account cost implications and local resources...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28694132/inflammatory-bowel-disease-and-small-bowel-cancer-risk-%C3%A2-clinical-characteristics-and-histopathology-a%C3%A2-population-based-study
#19
Rasmus Dahlin Bojesen, Lene Buhl Riis, Estrid Høgdall, Ole Haagen Nielsen, Tine Jess
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) may increase risk of small bowel cancer (SBC). However, little is known of the characteristics and features of IBD-SBC, due to a low number of cases worldwide. We performed a population-based study of IBD and SBC to calculate risk and increase our understanding of clinical characteristics and histopathological and molecular features. METHODS: The study population consisted of all individuals aged 16 years or older living in Denmark during 1978-2010...
July 8, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28694116/effect-of-bladder-distension-on-doses-to-organs-at-risk-in-pulsed-dose-rate-3d-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#20
Jean Philippe Nesseler, Claire Charra-Brunaud, Julia Salleron, Jean François Py, Andres Huertas, Emilie Meknaci, Florent Courrech, Didier Peiffert, Sophie Renard-Oldrini
PURPOSE: To evaluate the impact of bladder distension on doses to organs at risk in patients treated with 3D image-guided adaptive pulsed-dose-rate (PDR) brachytherapy (BT) for locally advanced cervical cancer. METHODS AND MATERIALS: Twenty-two patients who had previously been treated by external beam radiation therapy (EBRT), underwent BT treatment planning to a pelvic MRI (or a CT scan in case of contraindication) after their bladder was filled with 100 cc of physiological saline (full bladder)...
July 7, 2017: Brachytherapy
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