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https://www.readbyqxmd.com/read/28303507/laparoscopic-conversion-of-one-anastomosis-gastric-bypass-to-a-standard-roux-en-y-gastric-bypass
#1
Imed Ben Amor, Niccolo Petrucciani, Radwan Kassir, Abdullah Al Munifi, Thierry Piche, Tarek Debs, Jean Gugenheim
INTRODUCTION: One anastomosis gastric bypass (OAGB) demonstrated results similar to traditional Roux-en-Y procedures [1-3], in terms of weight loss and resolution of obesity-related comorbidities. The main controversy regarding OAGB is the concern for an association between biliary alkaline gastritis and esophageal or gastric cancer raised by some studies [4]. METHODS: We present the case of a 51-year-old woman with a BMI of 41 kg/m2 who underwent a laparoscopic OAGB in 2014...
March 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28303455/duodenal-cancer-in-a-young-patient-with-peuts-jeghers-syndrome-harboring-an-entire-deletion-of-the-stk11-gene
#2
Satoshi Teramae, Koichi Okamoto, Kumiko Tanaka, Reika Matsumoto, Shinji Kitamura, Tetsuo Kimura, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Yoshimi Bando, Mitsuo Shimada, Tetsuji Takayama
A 21-year-old woman with Peuts-Jeghers syndrome (PJS) was referred to our hospital for gastrointestinal surveillance. She had been diagnosed as having PJS from a young age based on her family history and the presence of mucocutaneous pigmentation on her lips and oral mucosa. Her mother and brother had PJS harboring an entire deletion of the STK11 gene. She had tetralogy of Fallot, atrial tachycardia, sick sinus syndrome, and mental retardation in her past history. Esophagogastroduodenoscopy identified a protruded lesion with a depressed area that occupied the lumen half-circumferentially in the duodenal second portion and also showed a 10-mm protruded lesion on the anterior wall of the lower gastric body...
March 16, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28300658/effect-of-particle-size-on-the-biodistribution-toxicity-and-efficacy-of-drug-loaded-polymeric-nanoparticles-in-chemoradiotherapy
#3
Joseph M Caster, Stephanie K Yu, Artish N Patel, Nicole J Newman, Zachary J Lee, Samuel B Warner, Kyle T Wagner, Kyle C Roche, Xi Tian, Yuanzeng Min, Andrew Z Wang
Nanoparticle (NP) therapeutics can improve the therapeutic index of chemoradiotherapy (CRT). However, the effect of NP physical properties, such particle size, on CRT is unknown. To address this, we examined the effects of NP size on biodistribution, efficacy and toxicity in CRT. PEG-PLGA NPs (50, 100, 150nm mean diameters) encapsulating wotrmannin (wtmn) or KU50019 were formulated. These NP formulations were potent radiosensitizers in vitro in HT29, SW480, and lovo rectal cancer lines. In vivo, the smallest particles avoided hepatic and splenic accumulation while more homogeneously penetrating tumor xenografts than larger particles...
March 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28297436/simultaneously-integrated-boost-sib-spares-oar-and-reduces-treatment-time-in-locally-advanced-cervical-cancer
#4
Christine H Feng, Yasmin Hasan, Malgorzata Kopec, Hania A Al-Hallaq
We performed a dosimetric comparison of sequential IMRT (sIMRT) and simultaneously integrated boost (SIB) IMRT to boost PET-avid lymph nodes while concurrently treating pelvic targets to determine the potential of SIB IMRT to reduce overall treatment duration in locally advanced cervical cancer. Ten patients receiving definitive radiation therapy were identified retrospectively. RTOG consensus guidelines were followed to delineate the clinical target volume and organs at risk (OAR), which were then expanded per IMRT consortium guidelines to yield the planning target volume (PTV)...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28292663/ileal-strangulation-by-a-secondary-perineal-hernia-after-laparoscopic-abdominoperineal-rectal-resection-a-case-report
#5
Kurokawa Tomohiro, Giichiro Tsurita, Kentaro Yazawa, Masaru Shinozaki
INTRODUCITON: We report a recent case of strangulated bowel obstruction due to an incarcerated secondary perineal hernia that developed after laparoscopic rectal resection. PRESENTATION OF CASE: A 75-year-old man undergoing treatment for alcoholic cirrhosis underwent laparoscopic abdominoperineal resection of the rectum (APR) for lower rectal cancer after preoperative chemoradiotherapy. Lung metastases were diagnosed 2 months postoperatively. Ten days after chemotherapy initiation, the patient was hospitalized on an emergency basis due to hepatic encephalopathy...
February 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28291936/dosimetric-benefits-of-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy-in-the-treatment-of-postoperative-cervical-cancer-patients
#6
Xia Deng, Ce Han, Shan Chen, Congying Xie, Jinling Yi, Yongqiang Zhou, Xiaomin Zheng, Zhenxiang Deng, Xiance Jin
As the advantage of using complex volumetric-modulated arc therapy (VMAT) in the treatment of gynecologic cancer has not yet been fully determined, the purpose of this study was to investigate the dosimetric advantages of VMAT by comparing directly with whole pelvic conformal radiotherapy (CRT) and intensity-modulated radiotherapy (IMRT) in the treatment of 15 postoperative cervical cancer patients. Four-field CRT, seven-field IMRT, and two-arc VMAT plans were generated for each patient with identical objective functions to achieve clinically acceptable dose distribution...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28287935/heterotopic-pancreas-histopathologic-features-imaging-findings-and-complications
#7
Maryam Rezvani, Christine Menias, Kumaresan Sandrasegaran, Jeffrey D Olpin, Khaled M Elsayes, Akram M Shaaban
Heterotopic pancreas is a congenital anomaly in which pancreatic tissue is anatomically separate from the main gland. The most common locations of this displacement include the upper gastrointestinal tract-specifically, the stomach, duodenum, and proximal jejunum. Less common sites are the esophagus, ileum, Meckel diverticulum, biliary tree, mesentery, and spleen. Uncomplicated heterotopic pancreas is typically asymptomatic, with the lesion being discovered incidentally during an unrelated surgery, during an imaging examination, or at autopsy...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28271639/first-australian-experience-of-treating-localised-prostate-cancer-patients-with-cyberknife-stereotactic-radiotherapy-early-psa-response-acute-toxicity-and-quality-of-life
#8
Ashutosh Dixit, Colin Tang, Sean Bydder, Mary-Anne Kedda, Eva Vosikova, Chrianna Bharat, Suki Gill
INTRODUCTION: This study is to evaluate biochemical response, acute toxicity and health-related quality-of-life (QOL) outcomes among prostate cancer patients following stereotactic body radiation therapy (SBRT) in the first Australian CyberKnife facility. METHODS: Forty-five consecutive patients with clinically localised prostate cancer were treated with SBRT using CyberKnife technology and enrolled in this study. Protocol treatment consisted of 36.25 Gy in five fractions...
March 8, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28261835/systematic-review-with-meta-analysis-use-of-5-aminosalicylates-and-risk-of-colorectal-neoplasia-in-patients-with-inflammatory-bowel-disease
#9
REVIEW
S Bonovas, G Fiorino, T Lytras, G Nikolopoulos, L Peyrin-Biroulet, S Danese
BACKGROUND: The relationship of 5-aminosalicylates' use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. AIM: To investigate this association through an updated meta-analysis of observational studies. METHODS: PubMed, Scopus and major conference proceedings were searched up to December 2016. The identified studies were evaluated for publication bias and heterogeneity...
March 6, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28252278/bifunctional-succinylated-%C3%AE%C2%B5-polylysine-coated-mesoporous-silica-nanoparticles-for-ph-responsive-and-intracellular-drug-delivery-targeting-the-colon
#10
Chau T H Nguyen, Richard I Webb, Lynette K Lambert, Ekaterina Strounina, Edward C Lee, Marie-Odile Parat, Michael A McGuckin, Amirali Popat, Peter J Cabot, Benjamin P Ross
Conventional oral drug formulations for colonic diseases require the administration of high doses of drug to achieve effective drug concentrations at the target site. However, this exposes patients to serious systemic toxicity in order to achieve efficacy. To overcome this problem, an oral drug delivery system was developed by loading a large amount (ca. 34% w/w) of prednisolone into 3-aminopropyl-functionalized mesoporous silica nanoparticles (MCM-NH2) and targeting prednisolone release to the colon by coating the nanoparticle with succinylated ε-polylysine (SPL)...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28248632/faecal-occult-blood-testing-fobt-based-colorectal-cancer-screening-trends-and-predictors-of-non-use-findings-from-the-south-australian-setting-and-implications-for-increasing-fobt-uptake
#11
Kamelia Todorov, Carlene Wilson, Greg Sharplin, Nadia Corsini
Objective The present study used data from three South Australian population health surveys to examine trends in knowledge, recent use and reasons for use or non-use of faecal occult blood testing (FOBT) for colorectal cancer (CRC) screening from 2011 to 2014. Screening awareness and demographic factors related to non-use were also examined.Methods FOBT trends were examined for respondents aged 50-75 years across survey years (n ~ 1000). Logistic regression analyses were undertaken to determine predictors of non-use and reasons for non-use of FOBT based on latest data...
March 2, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28244408/tolerability-of-concurrent-chemoradiation-therapy-with-gemcitabine-gemx-with-and-without-prior-neoadjuvant-chemotherapy-in-muscle-invasive-bladder-cancer
#12
Catherine Thompson, Nuradh Joseph, Benjamin Sanderson, John Logue, James Wylie, Tony Elliott, Jeanette Lyons, Carmel Anandadas, Ananya Choudhury
PURPOSE: The aim of this study is to assess the tolerability of concurrent chemoradiation therapy with gemcitabine (GemX) in muscle invasive bladder cancer following neoadjuvant chemotherapy (neoGemX) by use of patient- and provider-reported outcomes. METHODS AND MATERIALS: Seventy-eight patients were treated with GemX. Thirty-eight received prior neoadjuvant chemotherapy (NAC). Patients were prospectively assessed during treatment and at 6 weeks and 12 months after treatment completion...
March 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28243822/robotic-repair-of-vaginal-evisceration-after-hysterectomy-and-the-role-of-intraoperative-near-infrared-fluorescence-imaging
#13
Melis Canturk, Volkan Ozben, Mehmet Faruk Kose, Bilgi Baca
Vaginal evisceration of the small bowel is a rare and potentially life-threatening complication after hysterectomy. This complication requires prompt surgical management and methods of surgical repair include abdominal, vaginal or laparoscopic approaches. We report the first case of robotic approach for repair of vaginal evisceration and intraoperative use of near-infrared fluorescence imaging for the assessment of bowel perfusion in a 63-year-old postmenopausal woman with a history of robotic hysterectomy for cervix cancer...
February 27, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28239324/capsule-retention-caused-by-duodenal-metastases-from-primary-appendiceal-adenocarcinoma
#14
Jen-Wei Chou, Ken-Sheng Cheng
Metastatic small bowel cancers are extremely rare in clinical practice. Primary appendiceal adenocarcinoma with gastrointestinal metastasis is seldom reported in the literature. Here, we describe the case of an 80-year-old male patient with primary appendiceal adenocarcinoma, who presented to China Medical University Hospital with mid-gastrointestinal tract bleeding. Capsule endoscopy revealed stenotic bowel lumen, but the capsule was retained in the distal duodenum. Double-balloon enteroscopy demonstrated erosive and erythematous mucosa in the region of capsule retention...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28237283/ablative-therapies-for-renal-tumors-patient-selection-treatment-planning-and-follow-up
#15
Jean-Michel Correas, Christophe Delavaud, Jules Gregory, Thomas Le Guilchet, Lionel Lamhaut, Marc-Olivier Timsit, Arnaud Méjean, Olivier Hélénon
The increased use of abdominal imaging has led to a major increase in small renal tumors incidence particularly in the elderly population. Their management is evolving with the development of percutaneous ablation, particularly radiofrequency ablation, cryoablation, and microwave ablation. The typical indications that must be validated by a multidisciplinary committee include solid tumors less than 3cm in patients with multiple comorbidity factors (including age), contraindications to surgery, hereditary renal cancer, bilateral renal tumors, solitary kidney, pre-existing chronic kidney disease, or at high risk of predialysis renal function after partial nephrectomy...
February 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28220185/small-bowel-protection-in-imrt-for-rectal-cancer-a%C3%A2-dosimetric-study-on-supine-vs-prone-position
#16
Julia Koeck, Katharina Kromer, Frank Lohr, Tobias Baack, Kerstin Siebenlist, Sabine Mai, Sylvia Büttner, Jens Fleckenstein, Frederik Wenz
BACKGROUND: This treatment planning study analyzes dose coverage and dose to organs at risk (OAR) in intensity-modulated radiotherapy (IMRT) of rectal cancer and compares prone vs. supine positioning as well as the effect of dose optimization for the small bowel (SB) by additional dose constraints in the inverse planning process. PATIENTS AND METHODS: Based on the CT datasets of ten male patients in both prone and supine position, a total of four different IMRT plans were created for each patient...
February 20, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28219849/surgical-management-of-malignant-bowel-obstruction-in-recurrent-pancreatic-cancer
#17
Hyung Sun Kim, Joon Seong Park, Jin Hong Lim, Ja Hoon Back, Dong Sup Yoon
INTRODUCTION: Malignant bowel obstruction (MBO) is harrowing complication of gastrointestinal cancers. Only a few studies have reported on the surgical roles of bowel obstruction from recurrent pancreatic cancer. We report successfully management for malignant bowel obstruction by palliative surgery for relief of symptoms. PRESENTATION OF CASE: A 43 year old man was diagnosed with pancreatic tail cancer. After distal pancreatectomy, he underwent six cycle of adjuvant chemotherapy...
January 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28219690/factors-associated-with-shorter-colonoscopy-surveillance-intervals-for-patients-with-low-risk-colorectal-adenomas-and-effects-on-outcome
#18
Joseph C Anderson, John A Baron, Dennis J Ahnen, Elizabeth L Barry, Roberd M Bostick, Carol A Burke, Robert S Bresalier, Timothy R Church, Bernard F Cole, Marcia Cruz-Correa, Adam S Kim, Leila A Mott, Robert S Sandler, Douglas J Robertson
BACKGROUND & AIMS: Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs, 1-2 small tubular adenomas, less than 1 cm) every 5-10 years for colorectal cancer (CRC)-many endoscopists recommend shorter surveillance intervals for these individuals. We aimed to identify reasons that endoscopists recommend shorter surveillance intervals for some individuals with LRAs and determine whether timing affects outcomes at follow-up examinations. METHODS: We collected data from 1560 individuals (45-75 years old) who participated in a prospective chemoprevention trial (of vitamin D and calcium) from 2004 through 2008...
February 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28218383/stereotactic-ablative-radiation-therapy-as-a-potential-curative-treatment-in-duodenal-adenocarcinoma-a-case-report
#19
Francesco Maria Aquilanti, Maria Cristina Barba, Federico Bianciardi, Barbara Tolu, Barbara Nardiello, Giorgio Hamid Raza, Randa El Gawhary, Chiara D'Ambrosio, PierCarlo Gentile
PURPOSE: One of the rarest gastrointestinal neoplasm is small bowel cancer. Experience with its treatment modalities is limited. Stereotactic ablative radiation therapy (SABR) has improved, with image-guided radiation therapy becoming a curative option in many tumors. Especially when surgery cannot be performed due to comorbidities, SABR provides a good toxicity profile and an excellent tumor control rate owing to its specific schedule: high dose on a limited and well-defined area. METHODS: An 83-year-old man had arterial hypertension and congestive cardiomyopathy, with recent history of upper abdominal pain, weight loss over 10 kg, and progressive severe fatigue...
February 11, 2017: Tumori
https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#20
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
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