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https://www.readbyqxmd.com/read/29683235/a-study-of-clinicopathologic-factors-as-indicators-for-early-prediction-of-suboptimal-debulking-surgery-after-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer
#1
Joo-Hyuk Son, Kyoungjin Chang, Tae-Wook Kong, Jiheum Paek, Suk-Joon Chang, Hee-Sug Ryu
AIM: This study aimed to evaluate early clinicopathologic factors predicting gross residual disease after neoadjuvant chemotherapy in patients with advanced epithelial ovarian cancer. METHODS: We analyzed clinicopathologic data of 68 patients with ovarian cancer who were treated with neoadjuvant chemotherapy followed by interval debulking surgery (NAC-IDS) between March 2006 and December 2016. All the patients received three cycles of NAC followed IDS. We evaluated all possible clinicopathologic characteristics, including reduction rates of serum CA-125 after each NAC and seven initial abdominopelvic computed tomography (CT) findings related to disease severity...
April 23, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29682620/a-prospective-cohort-study-of-patient-reported-vomiting-retching-nausea-and-antiemetic-use-during-neoadjuvant-long-course-radiation-therapy-and-concurrent-5-fluorouracil-based-chemotherapy-for-rectal-adenocarcinoma
#2
Kristopher Dennis, Liang Zeng, Carlo De Angelis, Hans Chung, Natalie Coburn, Edward Chow, C Shun Wong
Background and purpose: Antiemetic guidelines suggest daily prophylaxis with a serotonin3 receptor antagonist (5-HT3 RA) as an option for patients receiving long-course neoadjuvant radiation therapy and concurrent 5-fluorouracil-based chemotherapy for rectal cancer, despite the risks that 5-HT3 RA-induced constipation may pose. We explored the incidence of patient-reported vomiting, retching, nausea and antiemetic intake among patients in this setting to determine if these risks are justified...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29678273/preoperative-ct-based-predictive-factors-for-resectability-and-medium-term-overall-survival-in-patients-with-peritoneal-carcinomatosis-from-colorectal-cancer
#3
C Suzuki, H Wallgren, M Abraham-Nordling, G Palmer
AIM: To determine preoperative radiological findings that may correlate with resectability and medium-term overall survival (OS) in patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC). MATERIALS AND METHODS: The study included 81 consecutive patients with PC scheduled for cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). PCI scores from preoperative computed tomography (CT) were compared with Peritoneal Cancer Index (PCI) scores at laparotomy...
April 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29673922/patient-reported-outcomes-after-treatment-for-clinically-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Mónica Ávila, Laila Patel, Silvia López, Laura Cortés-Sanabria, Olatz Garin, Àngels Pont, Ferran Ferrer, Ana Boladeras, Victor Zamora, Sophie Fosså, Anne H Storås, Martin Sanda, Vicky Serra-Sutton, Montse Ferrer
BACKGROUND: The aim of this systematic review is to assess the impact of primary treatments with curative intention in patients with localized prostate cancer, measured with Patient-Reported Outcomes (PROs), and to examine differences among modalities within treatments. METHODS: We conducted a systematic literature search for January 2005-March 2017 following PRISMA guidelines, including longitudinal studies measuring disease-specific PROs in localized prostate cancer patients with a follow-up from pre- to post-treatment (≥1 year)...
April 3, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29666744/transvaginal-small-bowel-evisceration-following-abdominoperineal-resection
#5
Enver Kunduz, Huseyin Bektasoglu, Samet Yigman, Huseyin Akbulut
Abdominoperineal resection (APR) is one of the surgical techniques performed for the distal rectal cancer. The perineal herniation is one of the complications of APR surgery. In this report, we aim to demonstrate a rare case of small bowel evisceration and strangulation secondary to the transvaginal herniation evolved in the late stage after perineal hernia repair following laparoscopic APR.
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29662560/impact-of-68-ga-dota-peptide-pet-ct-on-the-management-of-gastrointestinal-neuroendocrine-tumour-gi-net-malaysian-national-referral-centre-experience
#6
Teik Hin Tan, Ching Yeen Boey, Boon Nang Lee
Purpose: The National Cancer Institute is the only referral centre in Malaysia that provides 68 Ga-DOTA-peptide imaging. The purpose of this study is to determine the impact of 68 Ga-DOTA-peptide PET/CT on the management of gastrointestinal neuroendocrine tumours (GI-NET). Materials and Methods: A cross-sectional study was performed to review the impact of 68 Ga-DOTA-peptide (68 Ga-DOTATATE or 68 Ga-DOTATOC) PET/CT on patients with biopsy-proven GI-NET between January 2011 and December 2015...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29653092/cd10-inhibits-cell-motility-but-expression-is-associated-with-advanced-stage-disease-in-colorectal-cancer
#7
Teresa P Raposo, Mireia Sueca Comes, Adeyemi Idowu, Bora Agit, James Hassall, Wakkas Fadhil, Robert Nica, Rupert Ecker, Takashi Yao, Mohammad Ilyas
INTRODUCTION: CD10 is a cell membrane-bound endopeptidase which is expressed in normal small bowel but not in normal colon. It is aberrantly expressed in a small proportion of colorectal cancers (CRC) and this has been associated with liver metastasis and poor prognosis. We sought to investigate the mechanism of CD10 activity and its association with clinicopathological features. MATERIAL AND METHODS: CD10 was stably knocked down by lentiviral shRNA transduction in the CRC cell lines SW480 and SW620 which are derived from a primary tumour and its corresponding metastasis respectively...
April 10, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29651671/are-endometrial-cancer-radiotherapy-results-age-related
#8
Á Rovirosa, K S Cortés, C Ascaso, A Glickman, S Valdés, A Herreros, C Camacho, J Sánchez, Y Zhang, Y Li, S Sabater, M Arenas, A Torne
OBJECTIVE: To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis. MATERIALS AND METHODS: From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups: Group-1: 202 patients < 65 years; Group-2: 210 patients ≥ 65 and < 80 years; Group-3: 26 patients ≥ 80 years...
April 12, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29650827/-a-case-report-of-complete-resection-of-the-recurrence-small-intestinal-carcinoma-with-abdominal-wall-repair-using-femoral-fascia
#9
Tadafumi Fukata, Taishi Hata, Tateki Kubo, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Chu Matsuda, Tsunekazu Mizushima, Kou Hosokawa, Yuichiro Doki, Masaki Mori
The patients had Hartmann's operation for rectal cancer when she was 61 years old. After that, she underwent the operation for small bowel cancer when she was 68 years old. After 5 months, the only metastatic lesion was detected near the Scolon stoma. For the first therapy, She received chemotherapy(mFOLFOX6 plus bevacizumab)and had a reducing effect. She was introduced to our hospital for the purpose of resection of the recurrent lesion. CT scan detected a nodule near the Scolon stoma with FDG uptake for PET-CT scan...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650418/inflammatory-bowel-disease-drastically-affects-the-prognosis-of-patients-treated-for-peritoneal-metastases-with-combined-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-multicenter-study
#10
Nassim Hammoudi, Clarisse Eveno, Jérôme Lambert, Marianne Maillet, Olivier Glehen, Diane Goere, Nelson Lourenco, Matthieu Allez, Thomas Aparicio, Marc Pocard, Jean-Marc Gornet
BACKGROUND: Complete cytoreductive surgery (CCRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a validated treatment in selected patients with peritoneal metastases (PM) of intestinal origin. There is an increased risk of Colorectal Cancer (CRC) and Small Bowel Adenocarcinoma (SBA) in Inflammatory Bowel Disease (IBD). The feasibility and benefit of that surgical approach in IBD patients is unknown. METHODS: IBD patients with operated PM complicating CRC or SBA were extracted from a French national multicenter prospective database of patients who underwent surgery for PM in HIPEC expert centers from 1995 to 2016...
March 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29615974/presence-and-effects-of-pituitary-adenylate-cyclase-activating-polypeptide-under-physiological-and-pathological-conditions-in-the-stomach
#11
REVIEW
Dora Reglodi, Anita Illes, Balazs Opper, Eszter Schafer, Andrea Tamas, Gabriella Horvath
Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide with widespread occurrence throughout the body including the gastrointestinal system. In the small and large intestine, effects of PACAP on cell proliferation, secretion, motility, gut immunology and blood flow, as well as its importance in bowel inflammatory reactions and cancer development have been shown and reviewed earlier. However, no current review is available on the actions of PACAP in the stomach in spite of numerous data published on the gastric presence and actions of the peptide...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29607805/intestinal-ostomy
#12
Peter C Ambe, Nadja Rebecca Kurz, Claudia Nitschke, Siad F Odeh, Gabriela Möslein, Hubert Zirngibl
BACKGROUND: About 100 000 ostomy carriers are estimated to live in Germany today. The creation of an ostomy represents a major life event that can be associated with impaired quality of life. Optimal ostomy creation and proper ostomy care are crucially important determinants of the success of treatment and of the patients' quality of life. METHODS: This article is based on pertinent publications retrieved by a selective search in PubMed, GoogleScholar, and Scopus, and on the authors' experience...
March 16, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29595689/single-port-surgery-sps-strategy-for-small-bowel-obstruction-sbo-caused-by-postoperative-internal-hernia-a-series-case-report
#13
Kohei Taniguchi, Ryo Iida, Koshi Ota, Mitsuhiro Asakuma, Kazuhisa Uchiyama, Akira Takasu
RATIONALE: Internal hernia due to postoperative adhesions sometimes causes small bowel obstruction (SBO) and requires emergency surgery. The difficulties in the management of SBO with internal hernia include accurate diagnosis and estimation of its ischemic degree and of the risk of SBO recurrences following the surgical procedure. Laparoscopic surgery is a noninvasive to reduce postoperative adhesions and therefore has been widely used recently. However, surgeons often tend to hesitate in applying laparoscopic surgery for SBO because of some situational disadvantages such as poor operating space or iatrogenic bowel injury...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29589108/chronic-diarrhoea-following-surgery-for-colon-cancer-frequency-causes-and-treatment-options
#14
REVIEW
Jonathan Yde, Helene M Larsen, Søren Laurberg, Klaus Krogh, Hanne B Moeller
PURPOSE: The growing population of survivors after colon cancer warrants increased attention to the long-term outcome of surgical treatment. The change in bowel anatomy after resection disrupts normal gastrointestinal function and may cause symptoms. Thus, many patients surviving colon cancer have to cope with bowel dysfunction for the rest of their lives. We here aim to provide an overview of the literature on this topic. METHODS: We review long-term functional outcomes of surgical treatment for colon cancer, the underlying pathology, and treatment options...
March 27, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29581814/a-rare-case-of-colonic-metastases-from-tonsillar-carcinoma-case-report-and-review-of-literature
#15
Hassan Tariq, Muhammad Umar Kamal, Shehriyar Mehershahi, Muhammad Saad, Sara Azam, Kishore Kumar, Masooma Niazi, Jasbir Makker, Myrta Daniel
The incidence of tonsillar cancer has increased by four times in the United States over the last few decades likely due to recent increase in human papilloma virus (HPV) infections. The stage of the tumor predicts likelihood of metastasis, with advanced stages associated with higher chances of metastasis. The squamous cell carcinomas (SCCs) of the head and neck commonly metastasize to the lung, bone and liver in descending order. Tonsillar cancer rarely involves the small bowel and our review of the literature did not reveal any reported case of metastasis to the colon/large bowel...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29578161/incidence-of-radiation-enteritis-in-cervical-cancer-patients-treated-with-definitive-radiotherapy-versus-adjuvant-radiotherapy
#16
Yinuo Wang, Weimin Kong, Nanan Lv, Fengshuang Li, Jiao Chen, Simeng Jiao, Ding Ding, Hui Zhao, Dan Song
Objective: The study aimed to evaluate the incidence of early and late radiation enteritis in cervical cancer patients receiving definitive or adjuvant radiotherapy (RT). Materials and Methods: Three hundred and twenty-four cervical cancer patients receiving definite or adjuvant RT in our hospital from January 2010 to December 2012 were divided into definitive (132 patients) or adjuvant RT (192 patients) and performed detailed analysis. Results: Early radiation enteritis was found in 54...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29573921/the-impact-of-daily-bladder-filling-on-small-bowel-dose-for-intensity-modulated-radiation-therapy-for-cervical-cancer
#17
Victor E Chen, Erin F Gillespie, Ryan P Manger, Lauren A Skerritt, Josephine H Tran, James A Proudfoot, Michael V Sherer, John P Einck, Loren K Mell, Kevin L Moore, Catheryn M Yashar
Research demonstrates that instructing patients to have a full bladder for pelvic radiotherapy results in highly variable bladder volumes at daily treatment. We aimed to determine bladder volume variation in patients with intact cervical cancer treated with intensity-modulated radiotherapy (IMRT) on an empty bladder and estimate the difference in radiation dose to the small bowel compared to treating on a full bladder. We identified 29 patients treated with IMRT from 2010 to 2013 who underwent 2 planning computed tomography (CT) scans, 1 with a full bladder followed by 1 with an empty bladder...
March 21, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29573744/optimization-of-treatment-planning-workflow-and-tumor-coverage-during-daily-adaptive-magnetic-resonance-image-guided-radiation-therapy-mr-igrt-of-pancreatic-cancer
#18
Sven Olberg, Olga Green, Bin Cai, Deshan Yang, Vivian Rodriguez, Hao Zhang, Jin Sung Kim, Parag J Parikh, Sasa Mutic, Justin C Park
BACKGROUND: To simplify the adaptive treatment planning workflow while achieving the optimal tumor-dose coverage in pancreatic cancer patients undergoing daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT). METHODS: In daily adaptive MR-IGRT, the plan objective function constructed during simulation is used for plan re-optimization throughout the course of treatment. In this study, we have constructed the initial objective functions using two methods for 16 pancreatic cancer patients treated with the ViewRay™ MR-IGRT system: 1) the conventional method that handles the stomach, duodenum, small bowel, and large bowel as separate organs at risk (OARs) and 2) the OAR grouping method...
March 24, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29566385/a-comprehensive-assessment-of-the-role-of-mirnas-as-biomarkers-in-gastroenteropancreatic-neuroendocrine-tumors
#19
Anna Malczewska, Mark Kidd, Somer Matar, Beata Kos-Kudla, Irvin M Modlin
BACKGROUND/AIMS: A key issue in neuroendocrine neoplasia management is the identification of blood signatures that specifically define the activity of a cancer or local tumor microenvironment. MicroRNAs (miRNAs) may represent such a candidate. To evaluate their clinical utility as biomarkers in gastroenteropancreatic neuroendocrine tumors (GEP-NETs), we assessed their expression in tissue and blood. METHODS: A systematic review of PubMed was undertaken to identify studies investigating miRNAs in GEP-NETs and their utility as blood or tissue biomarkers...
March 22, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/29562381/when-perforation-is-not-the-culprit-case-report-and-systematic-review-of-mechanical-small-bowel-obstruction-complicating-colonoscopy
#20
V Papastergiou, N Mathou, K Manes, P Maniatis, K Paraskeva, A Evgenidi, A Giannakopoulos, J A Karagiannis
Colonoscopy is generally safe, although expansion of colorectal cancer prevention programs is likely to increase the number of post-colonoscopy complications. We report the case of a 42-year old woman with a prior history of 2 cesarean section deliveries who developed abdominal pain after an otherwise uneventful screening colonoscopy. Urgent exploration revealed closed-loop obstruction involving the terminal ileum, caused by an adhesive band close to the site of her previous Pfannenstiel incision. A systematic review of the literature revealed 11 reports (1985-2008) describing a total of 13 cases of mechanical small bowel obstruction (MSBO) after colonoscopy, 9 of which were confirmed by laparotomy...
January 2018: Acta Gastro-enterologica Belgica
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