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Behavioral Biology

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https://www.readbyqxmd.com/read/28934847/participation-of-ccl1-in-snail-positive-fibroblasts-in-colorectal-cancer-contribute-to-5-fluorouracil-paclitaxel-chemoresistance
#1
Ziqian Li, Kaying Chan, Yifei Qi, Linlin Lu, Fen Ning, Mengling Wu, Yuan Wang, Shaohui Cai, Jun Du
Purpose: Cancer-associated fibroblasts (CAFs) activated by cancer cells has a central role in development and malignant biological behavior in colorectal cancer (CRC). Adult fibroblasts do not express Snail, but Snail-positive fibroblasts are discovered in the stroma of malignant CRC and reported to be the key role to chemoresistance. However, the reciprocal effect of CAFs expressed Snail to chemoresistance on CRC cells and the underlying molecular mechanisms are not fully characterized...
September 18, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28934609/quantitative-measurement-of-sodium-polystyrene-sulfonate-adsorption-onto-ctab-capped-gold-nanoparticles-reveals-hard-and-soft-coronas
#2
Celina M Harris, Savannah G Miller, Kurt Andresen, Lucas B Thompson
Accumulated evidence indicates that nanoparticle behavior in complex biological environments strongly depends on the nanoparticles' surface chemistry. A common way to modify nanoparticles is to deposit oppositely charged molecules on the surfaces in a Layer-by-Layer fashion to build up thin films of polymers. While this polymer coating is a well-developed technique, the quantification of polymers deposited and physical mechanism of polymer deposition remain relatively unstudied. In this work CTAB capped gold nanoparticles, synthesized in a flow reactor, are coated with sodium polystyrene sulfonate and purified through a series of equilibrium dialysis steps...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28934501/model-based-design-of-rna-hybridization-networks-implemented-in-living-cells
#3
Guillermo Rodrigo, Satya Prakash, Shensi Shen, Eszter Majer, José-Antonio Daròs, Alfonso Jaramillo
Synthetic gene circuits allow the behavior of living cells to be reprogrammed, and non-coding small RNAs (sRNAs) are increasingly being used as programmable regulators of gene expression. However, sRNAs (natural or synthetic) are generally used to regulate single target genes, while complex dynamic behaviors would require networks of sRNAs regulating each other. Here, we report a strategy for implementing such networks that exploits hybridization reactions carried out exclusively by multifaceted sRNAs that are both targets of and triggers for other sRNAs...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28933288/stem-cell-differentiation-stage-factors-and-their-role-in-triggering-symmetry-breaking-processes-during-cancer-development-a-quantum-field-theory-model-for-reprogramming-cancer-cells-to-healthy-phenotypes
#4
Pier Mario Biava, Fabio Burigana, Roberto Germano, Philip Kurian, Claudio Verzegnassi, Giuseppe Vitiello
A long history of research has pursued the use of embryonic factors isolated during cell differentiation processes for the express purpose of transforming cancer cells back to healthy phenotypes. Recent results have clarified that the substances present at different stages of cell differentiation-which we call stem cell differentiation stage factors (SCDSFs)-are proteins with low molecular weight and nucleic acids that regulate genomic expression. The present review summarizes how these substances, taken at different stages of cellular maturation, are able to retard proliferation of many human tumor cell lines and thereby reprogram cancer cells to healthy phenotypes...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933001/redefining-aging-in-hiv-infection-using-phenotypes
#5
REVIEW
David M Stoff, Karl Goodkin, Dilip Jeste, Maria Marquine
PURPOSE OF REVIEW: This article critically reviews the utility of "phenotypes" as behavioral descriptors in aging/HIV research that inform biological underpinnings and treatment development. We adopt a phenotypic redefinition of aging conceptualized within a broader context of HIV infection and of aging. Phenotypes are defined as dimensions of behavior, closely related to fundamental mechanisms, and, thus, may be more informative than chronological age. Primary emphasis in this review is given to comorbid aging and cognitive aging, though other phenotypes (i...
September 20, 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/28932213/petri-net-based-model-of-helicobacter-pylori-mediated-disruption-of-tight-junction-proteins-in-stomach-lining-during-gastric-carcinoma
#6
Anam Naz, Ayesha Obaid, Faryal M Awan, Aqsa Ikram, Jamil Ahmad, Amjad Ali
Tight junctions help prevent the passage of digestive enzymes and microorganisms through the space between adjacent epithelial cells lining. However, Helicobacter pylori encoded virulence factors negatively regulate these tight junctions and contribute to dysfunction of gastric mucosa. Here, we have predicted the regulation of important tight junction proteins, such as Zonula occludens-1, Claudin-2 and Connexin32 in the presence of pathogenic proteins. Molecular events such as post translational modifications and crosstalk between phosphorylation, O-glycosylation, palmitoylation and methylation are explored which may compromise the integrity of these tight junction proteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28932042/small-cell-neuroendocrine-carcinoma-of-the-paranasal-sinus-with-intraoral-involvement-report-of-a-rare-case-and-review-of-the-literature
#7
Anita Spadigam, Anita Dhupar, Shaheen Syed, Shruti U Nagvekar
The diffuse neuroendocrine system continues to be an enigmatic topic of study in pathology due to its controversial embryologic origins, biology and a variety of tumors engendered. Originally thought to be localized to the classic neuroendocrine organs (pituitary, thyroid, pancreas and adrenal medulla), the neuroendocrine cells are now known to be distributed in every organ system of the body. A number of human diseases have been linked to aberrations in the functioning of the neuroendocrine cells. Neoplasms of the neuroendocrine system can thus occur in myriad primary sites and range in behavior from benign to lethal...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28931937/high-accuracy-label-free-classification-of-single-cell-kinetic-states-from-holographic-cytometry-of-human-melanoma-cells
#8
Miroslav Hejna, Aparna Jorapur, Jun S Song, Robert L Judson
Digital holographic cytometry (DHC) permits label-free visualization of adherent cells. Dozens of cellular features can be derived from segmentation of hologram-derived images. However, the accuracy of single cell classification by these features remains limited for most applications, and lack of standardization metrics has hindered independent experimental comparison and validation. Here we identify twenty-six DHC-derived features that provide biologically independent information across a variety of mammalian cell state transitions...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931782/tumor-necrosis-factor-%C3%AE-gene-expression-in-epicardial-adipose-tissue-is-related-to-coronary-atherosclerosis-assessed-by-computed-tomography
#9
Toshiro Kitagawa, Hideya Yamamoto, Takuya Hattori, Kazuhiro Sentani, Shinya Takahashi, Atsuhiro Senoo, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
AIMS: Tumor necrosis factor (TNF)-α reportedly has key pro-inflammatory properties in both atherosclerosis and adipocytes. To further investigate the biologic impact of epicardial adipose tissue (EAT) on coronary atherosclerosis, we evaluated the relationship between TNF-α gene expression in EAT and clinically-assessed coronary atherosclerosis on computed tomography (CT). METHODS: We studied 47 patients before cardiac surgery (coronary artery bypass grafting [CABG], n=26; non-CABG, n=21), assessing visceral adipose tissue (VAT) area, EAT volume, coronary calcium score (CCS), and the presence of non- and/or partially-calcified coronary plaque (NCP) on CT angiography...
September 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28931447/psychopathology-of-terrorists
#10
Armando Piccinni, Donatella Marazziti, Antonello Veltri
Terrorist behavior represents a subtype of human aggression probably determined by a combination of biological, psychological, and social factors, as well as by peculiar environmental influences and group dynamics. As regards terrorists' psychological characteristics, the available studies (mostly carried out with no sound scientific design) have failed to identify the common or typical pathological personality traits of modern terrorists. The popular opinion that terrorists must be insane or psychopathic is still widespread; however, no evidence exists that terrorist behavior may be caused either by prior or current psychiatric disorders or psychopathy...
September 21, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28930614/inter-species-functional-interactome-of-nuclear-steroid-receptors-r1
#11
Styliani A Geronikolou, Athanasia Pavlopoulou, Christina Kanaka-Gantenbein, George Chrousos
Steroids exert their actions by binding to the glucocorticoid, mineralocorticoid, androgen, estrogen and progesterone classes of receptors. Despite an exponential increase in our knowledge of steroid receptors, their interactions with other molecules, subcellular location and functions still need further elucidation. To unravel the mechanism(s) of action of the steroid hormones, as well as the function of their cognate nuclear receptors, an interaction network was created (henceforth referred to as "R1 Interactome")- illustrating that robust interactions have been preserved in rodents, frog, zebra fish and drosophila...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930355/conformations-and-membrane-driven-self-organization-of-rodlike-fd-virus-particles-on-freestanding-lipid-membranes
#12
Anastasiia B Petrova, Christoph Herold, Eugene P Petrov
Membrane-mediated interactions and aggregation of colloidal particles adsorbed to responsive elastic membranes are challenging problems relevant for understanding the microscopic organization and dynamics of biological membranes. We experimentally study the behavior of rodlike semiflexible fd virus particles electrostatically adsorbed to freestanding cationic lipid membranes and find that their behavior can be controlled by tuning the membrane charge and ionic strength of the surrounding medium. Three distinct interaction regimes of rodlike virus particles with responsive elastic membranes can be observed...
September 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28930163/zebrafish-in-translational-cancer-research-insight-into-leukemia-melanoma-glioma-and-endocrine-tumor-biology
#13
REVIEW
Aurora Irene Idilli, Francesca Precazzini, Maria Caterina Mione, Viviana Anelli
Over the past 15 years, zebrafish have emerged as a powerful tool for studying human cancers. Transgenic techniques have been employed to model different types of tumors, including leukemia, melanoma, glioblastoma and endocrine tumors. These models present histopathological and molecular conservation with their human cancer counterparts and have been fundamental for understanding mechanisms of tumor initiation and progression. Moreover, xenotransplantation of human cancer cells in embryos or adult zebrafish offers the advantage of studying the behavior of human cancer cells in a live organism...
September 20, 2017: Genes
https://www.readbyqxmd.com/read/28929788/the-familial-and-the-familiar-locating-relatedness-in-colombian-donor-conception
#14
Malissa Kay Shaw
In this article, I explore how women undergoing in-vitro fertilization with familial or anonymous egg donors located relatedness with a donor-conceived child through familial and social identities. Recognizing gametes as substances that contain biological and sociocultural/behavioral traits, shaped women's narratives around interconnected notions of the familial and familiar, or the social understanding of biological and social inheritance, and knowledge of the genetic materials involved. Women's narratives of relatedness reflect their relationships with family and society and their desire to reproduce these relationships in their child(ren), a process that reproduces prevailing Colombian social values and notions of ideal citizens...
September 20, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28929496/a-methylome-wide-association-study-of-trajectories-of-oppositional-defiant-behaviors-and-biological-overlap-with-attention-deficit-hyperactivity-disorder
#15
Edward D Barker, Esther Walton, Charlotte A M Cecil, Richard Rowe, Sara R Jaffee, Barbara Maughan, Thomas G O'Connor, Argyris Stringaris, Alan J Meehan, Wendy McArdle, Caroline L Relton, Tom R Gaunt
In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable...
September 20, 2017: Child Development
https://www.readbyqxmd.com/read/28929407/gibbs-free-energy-as-a-measure-of-complexity-correlates-with-time-within-c-elegans-embryonic-development
#16
Samuel H McGuire, Edward A Rietman, Hava Siegelmann, Jack A Tuszynski
We investigate free energy behavior in the nematode Caenorhabditis elegans during embryonic development. Our approach utilizes publicly available gene expression data, which gives us a picture of developmental changes in protein concentration and, resultantly, chemical potential and free energy. Our results indicate a clear global relationship between Gibbs free energy and time spent in development and provide thermodynamic indicators of the large-scale biological events of cell division and differentiation...
September 19, 2017: Journal of Biological Physics
https://www.readbyqxmd.com/read/28929304/embryonic-body-culturing-in-an-all-glass-microfluidic-device-with-laser-processed-4%C3%A2-%C3%AE-m-thick-ultra-thin-glass-sheet-filter
#17
Y Yalikun, N Tanaka, Y Hosokawa, T Iino, Y Tanaka
In this paper, we report the development and demonstration of a method to fabricate an all-glass microfluidic cell culturing device without circulation flow. On-chip microfluidic cell culturing is an indispensable technique for cellular replacement therapies and experimental cell biology. Polydimethylsiloxane (PDMS) have become a popular material for fabricating microfluidic cell culture devices because it is a transparent, biocompatible, deformable, easy-to-mold, and gas-permeable. However, PDMS is also a chemically and physically unstable material...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28928785/a-unique-case-of-clear-cell-variant-of-calcifying-epithelial-odontogenic-tumor-involving-the-maxilla
#18
Rudra Prasad Chatterjee, Swagata Gayen, Sanchita Kundu, Moumita Chattaraj, Mousumi Pal, Sanjeet Das
Calcifying epithelial odontogenic tumor (CEOT) is a rare, benign, odontogenic tumor arising from the odontogenic epithelium and accounts for approximately 1% of all odontogenic tumors. Clear cell variant of CEOT is a distinct entity and has more aggressive biological behavior and higher chances of recurrence. Here, we present a unique case of clear cell variant of CEOT involving the left side of the maxillary alveolus in a 73-year-old female patient with thorough clinical, radiological, and histological details...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28928667/thirty-five-day-fluoxetine-treatment-limits-sensory-motor-deficit-and-biochemical-disorders-in-a-rat-model-of-decompression-sickness
#19
Caroline Cosnard, Sébastien De Maistre, Jacques H Abraini, Laurent Chazalviel, Jean-Eric Blatteau, Jean-Jacques Risso, Nicolas Vallée
According to the OECD statistical base for 2014, anti-depressants will, on average, be distributed at a rate of 62 daily doses per 1,000 inhabitants for the 25 countries surveyed (Health at a glance: Europe 2014; OECD Health Statistics; World Health Organization and OECD Health Statistics, 2014). Divers must be concerned. On another hand, divers are potentially exposed to decompression sickness including coagulation inflammation and ischemia, which can result in neurological lesions or even death. The purpose of this study is to assess whether chronic treatment with anti-depressants may represent a contraindication to the practice of an at-risk activity, such as, scuba diving, or even presents a benefit by attenuating the severity of the symptoms...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28928019/benzoylecgonine-exposure-induced-oxidative-stress-and-altered-swimming-behavior-and-reproduction-in-daphnia-magna
#20
Marco Parolini, Beatrice De Felice, Claudia Ferrario, Noelia Salgueiro-González, Sara Castiglioni, Antonio Finizio, Paolo Tremolada
Several monitoring studies have shown that benzoylecgonine (BE) is the main illicit drug residue commonly measured in the aquatic system worldwide. Few studies have investigated the potential toxicity of this molecule towards invertebrate and vertebrate aquatic non-target organisms focusing on effects at low levels of the biological organization, but no one has assessed the consequences at higher ones. Thus, the present study was aimed at investigating the toxicity of a 48-h exposure to two concentrations of BE, similar to those found in aquatic ecosystems (0...
September 16, 2017: Environmental Pollution
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