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https://www.readbyqxmd.com/read/29156800/comparative-molecular-analyses-of-left-sided-colon-right-sided-colon-and-rectal-cancers
#1
Mohamed E Salem, Benjamin A Weinberg, Joanne Xiu, Wafik S El-Deiry, Jimmy J Hwang, Zoran Gatalica, Philip A Philip, Anthony F Shields, Heinz-Josef Lenz, John L Marshall
Tumor sidedness has emerged as an important prognostic and predictive factor in the treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right-sided colon cancers have a worse prognosis than those with left-sided colon or rectal cancers, and these patient subgroups respond differently to biological therapies. Historically, management of patients with metastatic colon and rectal cancers has been similar, and colon and rectal cancer patients have been grouped together in large clinical trials...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156731/mir-21-modulates-the-effect-of-ezh2-on-the-biological-behavior-of-human-lung-cancer-stem-cells-in-vitro
#2
Hui Xia, Wen Zhang, Baoshi Zhang, Yingnan Zhao, Yunlong Zhao, Shaojun Li, Yang Liu
Non-small-cell lung cancer has a high mortality rate and poor prognosis. Therefore, novel therapeutic approaches are urgently needed to enhance patient survival rates. In this study, we investigated the effects of miR-21 and EZH2 on the biological behavior of human lung cancer stem cells in vitro. We found increased expression of EZH2 and miR-21 in LCSCs, and miR-21 overexpression increased EZH2 levels in LCSCs. In addition, EZH2 and miR-21 knockdown increased the sensitivity of LCSCs to chemo- and radiation therapy, and exogenous EZH2 expression rescued the effects of anti-miR-21...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156291/engineering-the-next-generation-tin-containing-%C3%AE-titanium-alloys-with-high-strength-and-low-modulus-for-orthopedic-applications
#3
Sumit Bahl, Suvam Das, Satyam Suwas, Kaushik Chatterjee
Metastable β Ti alloys are the new emerging class of biomaterial for load bearing orthopedic applications. However, these alloys in the single β phase microstructure have insufficient strength for use in load bearing applications. It is imperative to strengthen these alloys by carefully designed thermo-mechanical processing routes that typically involve aging treatment. In this investigation two newly designed Sn based β Ti alloys of composition Ti-32Nb-(2, 4) Sn are evaluated. The effects of Sn content on the mechanical properties and biological performance of these alloys processed through designed thermo-mechanical processing route are investigated...
November 11, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29156185/maintenance-of-lost-weight-and-long-term-management-of-obesity
#4
REVIEW
Kevin D Hall, Scott Kahan
Weight loss can be achieved through a variety of modalities, but long-term maintenance of lost weight is much more challenging. Obesity interventions typically result in early weight loss followed by a weight plateau and progressive regain. This review describes current understanding of the biological, behavioral, and environmental factors driving this near-ubiquitous body weight trajectory and the implications for long-term weight management. Treatment of obesity requires ongoing clinical attention and weight maintenance-specific counseling to support sustainable healthful behaviors and positive weight regulation...
January 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29155786/isolation-and-cultivation-of-adult-rat-cardiomyocytes
#5
Franziska Nippert, Rolf Schreckenberg, Klaus-Dieter Schlüter
In an intact heart, adjacent cells influence adult cardiomyocytes. With the method of isolation and cultivation of adult cardiomyocytes, a precise investigation of the behavior of these cells under specific treatments and environments is possible. This manuscript presents a protocol for successful isolation and cultivation of adult rat ventricular cardiomyocytes (ARVC). The rat is sacrificed by cervical dislocation under deep anesthesia. Then, the heart is extracted and the aorta is uncovered. Subsequently, perfusion on the Langendorff perfusion system with calcium depletion and collagenase treatment is performed...
October 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155754/a-method-for-growing-bio-memristors-from-slime-mold
#6
Eduardo Reck Miranda, Edward Braund
Our research is aimed at gaining a better understanding of the electronic properties of organisms in order to engineer novel bioelectronic systems and computing architectures based on biology. This specific paper focuses on harnessing the unicellular slime mold Physarum polycephalum to develop bio-memristors (or biological memristors) and bio-computing devices. The memristor is a resistor that possesses memory. It is the 4th fundamental passive circuit element (the other three are the resistor, the capacitor, and the inductor), which is paving the way for the design of new kinds of computing systems; e...
November 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155562/quantification-of-nanomaterial-nanomedicine-trafficking-in-vivo
#7
Liming Wang, Liang Yan, Jing Liu, Chunying Chen, Yuliang Zhao
Absorption, distribution, metabolism and excretion (ADME) of nanomaterials (NMs) or nanomedicines (NMs), are fundamental biological processes that dominate their nanomedical functions or nanotoxicities. Mostly, NMs exist in biological systems as a form of nanoparticles (NPs). However, to determine the composition, spatial distribution, and states of existence of NMs/NPs in vivo, upon entry into the body, as well as to monitor the dynamic changes of these information over time remain a challenge for the current analytical methodology due to their limited efficiently in characterizing interactions between these complex(nano)-complex(bio) systems...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29155401/reconstructing-phylogenetic-tree-using-a-protein-protein-interaction-technique
#8
Shamita Malik, Dolly Sharma, Sunil Kumar Khatri
In this study, a novel substitution method for finding potential protein-protein interactions (PPIs) has been discussed. This newly designed method for analyzing PPI also aids in the comparison of evolutionary distances. The method deals with various data sets, and additionally performs measurable assessment to determine PPIs is introduced. PPIs are biologically relevant and aid in better conceptual framework of phylogenetic profiling. The newly designed framework gives vision to relate the topological properties of the system with evolutionary behavior of datasets...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29155028/chitosan-oligosaccharides-with-degree-of-polymerization-2-6-induces-apoptosis-in-human-colon-carcinoma-hct116%C3%A2-cells
#9
Pan Zou, Shoujun Yuan, Xin Yang, Xingchen Zhai, Jing Wang
Colon cancer is the third most common cancer, and yet there is a lack of effective therapeutic methods with low side effects. Chitosan oligosaccharides (COS) is derived from chitosan after chitin deacetylation, and attracts more interests due to smaller molecular weight and soluble property. Previously, COS, mainly absorbed through intestinal epithelia, has been reported to exhibit many bioactivities, especially its anti-tumor effect. Recent references pay little attention to molecular weight distribution which is crucial for understanding its biological behavior...
November 16, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29154930/suicide-attempts-in-children-and-adolescents-the-place-of-clock-genes-and-early-rhythm-dysfunction
#10
Bertrand Olliac, Lisa Ouss, Annaëlle Charrier
Suicide remains one of the leading causes of death among young people, and suicidal ideation and behavior are relatively common in healthy and clinical populations. Suicide risk in childhood and adolescence is often approached from the perspective of nosographic categories to which predictive variables for suicidal acts are often linked. The cascading effects resulting from altered clock genes in a pediatric population could participate in biological rhythm abnormalities and the emergence of suicide attempts through impaired regulation of circadian rhythms and emotional states with neurodevelopmental effects...
November 14, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/29154655/cognitive-functioning-in-toddlerhood-the-role-of-gestational-age-attention-capacities-and-maternal-stimulation
#11
Marjanneke de Jong, Marjolein Verhoeven, Ignace T C Hooge, Arnoldina P G F Maingay-Visser, Louise Spanjerberg, Anneloes L van Baar
Why do many preterm children show delays in development? An integrated model of biological risk, children's capacities, and maternal stimulation was investigated in relation to cognitive functioning at toddler age. Participants were 200 Dutch children (gestational age = 32-41 weeks); 51% boys, 96% Dutch nationality, 71.5% highly educated mothers. At 18 months, attention capacities were measured using eye-tracking, and maternal attention-directing behavior was observed. Cognitive functioning was measured at 24 months using the Bayley-III-NL...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29154622/how-does-not-left-become-right-electrophysiological-evidence-for-a-dynamic-conflict-bound-negation-processing-account
#12
Carolin Dudschig, Barbara Kaup
Human thought and language is traditionally considered as abstract, amodal, and symbolic. However, recent theories propose that high-level human cognition is directly linked to basic, modal biological systems such as sensorimotor areas. Despite this influential representational debate very little is known regarding whether the mechanisms involved in sensorimotor control are also shared with higher-level cognitive processes, such as language comprehension. We investigated negation as a universal of human language, addressing two key questions: (a) Does negation result in a conflict-like representation? (b) Does negation trigger executive control adjustments in a similar manner as standard information processing conflicts do (e...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154206/a-new-approach-in-separating-microplastics-from-environmental-samples-based-on-their-electrostatic-behavior
#13
Stefanie Felsing, Christian Kochleus, Sebastian Buchinger, Nicole Brennholt, Friederike Stock, Georg Reifferscheid
Numerous studies on microplastics (MPs; Ø < 5 mm) in the aquatic environment have been published, but knowledge about the occurrence and ecological risks of MPs is limited. This is in part because current data on the distribution of MPs are comparable only to a limited extent, due to the many different methods of investigation. In addition, sample preparation is often difficult such that standard procedures are lacking. The aim of this work was to simplify the preparation of different kinds of MP samples...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29153875/the-role-of-operating-parameters-and-oxidative-damage-mechanisms-of-advanced-chemical-oxidation-processes-in-the-combat-against-antibiotic-resistant-bacteria-and-resistance-genes-present-in-urban-wastewater
#14
REVIEW
I Michael-Kordatou, P Karaolia, D Fatta-Kassinos
An upsurge in the study of antibiotic resistance in the environment has been observed in the last decade. Nowadays, it is becoming increasingly clear that urban wastewater is a key source of antibiotic resistance determinants, i.e. antibiotic-resistant bacteria and antibiotic resistance genes (ARB&ARGs). Urban wastewater reuse has arisen as an important component of water resources management in the European Union and worldwide to address prolonged water scarcity issues. Especially, biological wastewater treatment processes (i...
October 27, 2017: Water Research
https://www.readbyqxmd.com/read/29153315/what-are-the-keys-to-a-longer-happier-life-answers-from-five-decades-of-health-psychology-research
#15
Blair T Johnson, Rebecca L Acabchuk
RATIONALE: It has long been known that factors of the mind and of interpersonal relationships influence health, but it is only in the last 50 years that an independent scientific field of health psychology appeared, dedicated to understanding psychological and behavioral processes in health, illness, and healthcare. OBJECTIVE AND METHOD: This article (a) reviews important research that answers the question of how human beings can have longer, happier lives; and (b) highlights trends in health psychology featuring articles in Social Science & Medicine as well as other related literature...
November 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29153180/a-100-year-review-progress-on-the-chemistry-of-milk-and-its-components
#16
John A Lucey, Don Otter, David S Horne
Understanding the chemistry of milk and its components is critical to the production of consistent, high-quality dairy products as well as the development of new dairy ingredients. Over the past 100 yr we have gone from believing that milk has only 3 protein fractions to identifying all the major and minor types of milk proteins as well as discovering that they have genetic variants. The structure and physical properties of most of the milk proteins have been extensively studied. The structure of the casein micelle has been the subject of many studies, and the initial views on submicelles have given way to the current model of the micelle as being assembled as a result of the concerted action of several types of interactions (including hydrophobic and the formation of calcium phosphate nanoclusters)...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153174/a-100-year-review-animal-welfare-in-the-journal-of-dairy-science-the-first-100-years
#17
Marina A G von Keyserlingk, Daniel M Weary
This paper outlines the history and development of research in the area of animal welfare as reflected in the 100 yr that the Journal of Dairy Science has been published. The first paper using the term "animal welfare" was published in 1983; since then (to May 2017), 244 papers that reflect growing interest regarding how farm animals are cared for have been published. Much of the scientific work to date has focused on issues related to cow health, such as lameness, and methodologically many papers use behavioral measures...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153165/a-100-year-review-historical-development-of-female-reproductive-physiology-in-dairy-cattle
#18
William W Thatcher
The objective of this historical review in female reproductive physiology is to encapsulate major advancements since the founding of the American Dairy Science Association in 1906. The emphasis is on landmark publications in the Journal of Dairy Science since its first volume in 1917. A historical perspective and inferences are made in forecasting evolution of female reproduction and links between physiology of reproduction and the mammary gland. Subsequent sections are focused into main physiological categories and the temporal advancements within these physiological windows...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29152631/mask-free-fabrication-of-a-versatile-microwell-chip-for-multidimensional-cellular-analysis-and-drug-screening
#19
Wenguang Yang, Haibo Yu, Gongxin Li, Fanan Wei, Yuechao Wang, Lianqing Liu
Cells are frequently studied because they are basic structural, functional, and biological units of living organisms. Extracting features from cellular behaviors can facilitate decision making in medical diagnoses and represents an important aspect in the development of biomedical engineering. Previous studies have just focused on either the individual cell or cell clusters separately, which leads to a great lack of information. Microwell technologies could address the challenges of in vitro cellular studies, from individual cell studies to 3D functional assays, by providing more information from smaller sample volumes and enabling the incorporation of low-cost high-throughput assays in the drug discovery process...
November 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29152050/consequences-of-depsipeptide-substitution-on-the-clpp-activation-activity-of-antibacterial-acyldepsipeptides
#20
Yangxiong Li, Nathan P Lavey, Jesse A Coker, Jessica E Knobbe, Dat C Truong, Hongtao Yu, Yu-Shan Lin, Susan L Nimmo, Adam S Duerfeldt
The acyldepsipeptide (ADEP) antibiotics operate through a clinically unexploited mechanism of action and thus have attracted attention from several antibacterial development groups. The ADEP scaffold is synthetically tractable, and deep-seated modifications have produced extremely potent antibacterial leads against Gram-positive pathogens. Although newly identified ADEP analogs demonstrate remarkable antibacterial activity against bacterial isolates and in mouse models of bacterial infections, stability issues pertaining to the depsipeptide core remain...
November 9, 2017: ACS Medicinal Chemistry Letters
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