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https://www.readbyqxmd.com/read/29051760/interplay-of-gtpases-and-cytoskeleton-in-cellular-barrier-defects-during-gut-inflammation
#1
REVIEW
Rocío López-Posadas, Michael Stürzl, Imke Atreya, Markus F Neurath, Nathalie Britzen-Laurent
An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune responses or the systemic dissemination of microbial agents, and preserve tissue homeostasis. Accordingly, alterations of epithelial and endothelial barrier functions have been associated with gut inflammation, for example during inflammatory bowel disease (IBD)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29050997/transient-elastography-to-assess-liver-stiffness-in-patients-with-inflammatory-bowel-disease
#2
Berrie Meijer, Charlotte K van Everdingen, Dewkoemar Ramsoekh, Catherine Stedman, Christopher M A Frampton, Chris J J Mulder, Gerd Bouma, Nanne K H de Boer, Richard B Gearry
BACKGROUND: Liver injury during inflammatory bowel disease (IBD) is primarily diagnosed by liver biopsy, which has a small but serious risk of severe complications. The aim of this study was to assess liver stiffness, and subsequently the prevalence and associations of liver fibrosis in IBD patients with thiopurine therapy and other clinical factors, by using transient elastography (TE). METHODS: In this prospective, international two-center study, included IBD-patients underwent TE measurements...
October 6, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29050458/endoscopic-treatment-of-jejunal-heterotopic-gastric-mucosa-that-caused-recurrent-intussusception
#3
Ke Ryun Ahn, Ja Seol Koo, Hwan Il Kim, Ji Hye Kim, Jee Hyun Lee, Seung Young Kim, Sung Woo Jung, Sang Woo Lee
Heterotopic gastric mucosa (HGM) is a rare anomaly in the small bowel and may be the cause of intussusception when it gets a lead point in the jejunum. All cases of intussusception due to intestinal HGM have been treated with surgical resection. A 5-year-old girl presented with chief complaints of vomiting and abdominal pain for 2 weeks. A computed tomography scan of the abdomen showed intussusception at the proximal jejunal loops. Three air reductions and one saline reduction were attempted without success...
October 18, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29049425/comparison-of-internal-medicine-and-general-surgery-residents-assessments-of-risk-of-postsurgical-complications-in-surgically-complex-patients
#4
James M Healy, Kimberly A Davis, Kevin Y Pei
Importance: Anticipating postsurgical complications is a vital physician skill, particularly when counseling surgically complex patients on their risks of intervention. Although internists and surgeons both counsel patients on surgical risks, it is uncertain who is better equipped to accurately anticipate surgical complications. Objective: To examine how internal medicine and general surgery trainees compare in their assessment of risk of surgically complex patients...
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049404/low-complexity-microbiota-in-the-duodenum-of-children-with-newly-diagnosed-ulcerative-colitis
#5
Fei Sjöberg, Cecilia Barkman, Intawat Nookaew, Sofia Östman, Ingegerd Adlerberth, Robert Saalman, Agnes E Wold
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by gut dysbiosis. To date, the large bowel microbiota has been in focus. However, the microbiota of the small intestine may also be of importance, as the small bowel is a site for the induction and control of mucosal immune responses, which can be modulated by constituents of the local microbiota. METHODS: Duodenal fluids were collected during diagnostic work-up of treatment-naïve children who were suspected of having IBD...
2017: PloS One
https://www.readbyqxmd.com/read/29049340/pressurized-intra-peritoneal-aerosol-chemotherapy-in-patients-suffering-from-peritoneal-carcinomatosis-of-pancreatic-adenocarcinoma
#6
Tanja Khosrawipour, Veria Khosrawipour, Urs Giger-Pabst
BACKGROUND: Patients suffering from peritoneal carcinomatosis of pancreatic adenocarcinoma were treated with Pressurized Intra Peritoneal Aerosol Chemotherapy (PIPAC), initial clinical findings are presented. METHODS: Single institution, tertiary referral center certified for therapy of peritoneal disease. Prospective data collection of PIPAC therapy with doxorubicin 1.5 mg/m2 and cisplatin 7.5 mg/m2 of body surface delivered at intervals of six weeks. The outcome criteria were microscopic pathological response, survival and adverse events (v4...
2017: PloS One
https://www.readbyqxmd.com/read/29049187/a-myeloid-sarcoma-involving-the-small-intestine-kidneys-mesentery-and-mesenteric-lymph-nodes-a-case-report-and-literature-review
#7
Ping Wang, Quan Li, Li Zhang, Hong Ji, Cheng-Zhou Zhang, Bin Wang
RATIONALE: Myeloid sarcomas (MSs) are rare malignant hematological tumors. They most commonly occur in patients with acute or chronic myeloid leukemia. A de novo MS with no evidence of blood system disease is rare, but may represent the first sign of a systemic illness that precedes a full-blown disease. Herein, we report the computed tomography (CT) findings of an extremely rare case of a nonleukemic MS that progressed to acute myelogenous leukemia (AML) and simultaneously involved the small intestine, kidneys, mesentery, and mesenteric lymph nodes...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046790/intraluminal-rectal-cancer-metastasis-to-the-small-bowel-an-extremely-rare-case-report
#8
Paraskevas Stamopoulos, Nikolaos Machairas, Stylianos Kykalos, Afrodite Nonni, Gregory Kouraklis, Georgios C Sotiropoulos
Prolonged survival in patients suffering from colorectal cancer (CRC) may lead to the emergence of rare metastatic sites that are not well-documented in the literature. We herein describe a very rare case of an intraluminal small intestinal metastasis in a patient with previously resected CRC. A 71-year-old Caucasian male patient with a history of rectosigmoid junction cancer was initially treated with anterior resection. The tumor was classified as pT3pN0 (0/26) M0, stage II. Eighteen months after the primary surgery, local recurrence was detected in the presacral region, and the patient received combined image-guided radiotherapy and chemotherapy...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046035/-laboratorial-alteration-preceding-staphylococcal-infection-clinical-manifestations-after-intestinal-transplantation
#9
Wilma Carvalho Neves Forte, Alliny Oliveira Carvalho Galvan, Pedro Salem Molino, Thais Roque, Tainá Mosca, Wangles Soler
BACKGROUND: Hospital-acquired infection, often with Staphylococcus aureus, is an important complication in intestinal transplant. CLINICAL CASE: A 2-year-old girl underwent small bowel transplantation owing to a small bowel volvulus. On the first postoperative day, lymphocyte phenotypes, serum immunoglobulins and chemotactic and phagocytic activity of neutrophils were assessed in peripheral blood. A decrease in the ingestion phase of phagocytosis by neutrophils was identified, in comparison with the results of 20 healthy children...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045179/clinical-relevance-of-the-feces-sign-in-small-bowel-obstruction-due-to-adhesions-depends-on-its-location
#10
Wassef Khaled, Ingrid Millet, Lucie Corno, Isabelle Bouley-Coletta, Mohamed Amine Benadjaoud, Patrice Taourel, Marc Zins
OBJECTIVE: The objective of our study was to evaluate if the feces sign can be used to predict successful nonoperative treatment or progression to ischemia in patients with small-bowel obstruction (SBO) due to adhesions. MATERIALS AND METHODS: For this single-center retrospective observational study involving a blinded independent review by two radiologists of 237 consecutive CT examinations of 216 patients with SBO due to adhesions (age: mean, 70.9 years; median, 74 years; interquartile range, 62-84 years), the location of the transition zone (TZ), number of TZs, and presence and location of the feces sign relative to the TZ were recorded...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29044591/duodenal-localization-is-a-negative-predictor-of-survival-after-small-bowel-adenocarcinoma-resection-a-population-based-propensity-score-matched-analysis
#11
Alexander Wilhelm, Christian Galata, Ulrich Beutner, Bruno M Schmied, Rene Warschkow, Thomas Steffen, Walter Brunner, Stefan Post, Lukas Marti
BACKGROUND AND OBJECTIVES: This study assessed the influence of tumor localization of small bowel adenocarcinoma on survival after surgical resection. METHODS: Patients with resected small bowel adenocarcinoma, ACJJ stage I-III, were identified from the Surveillance, Epidemiology, and End Results database from 2004 to 2013. The impact of tumor localization on overall and cancer-specific survival was assessed using Cox proportional hazard regression models with and without risk-adjustment and propensity score methods...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29043867/risk-factors-for-surgery-in-patients-with-retention-of-endoscopic-capsule
#12
Zemin Han, Weiguang Qiao, Xiuyun Ai, Aimin Li, Zhenyu Chen, Jie Zhang, Tianmo Wan, Xicheng Feng, Side Liu, Fachao Zhi
OBJECTIVES: Surgery is still the main means for removing retained endoscopic capsules. This study intended to evaluate risk factors for surgery in patients with capsule retention. MATERIALS AND METHODS: The data of 5348 consecutive capsule endoscopy examinations were retrospectively analyzed. Cox regression analysis was used to evaluate risk factors. RESULTS: Seventy-seven patients (1.4%) had capsule retention. Spontaneous passage occurred in 16 patients, of which 14 were asymptomatic...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043862/the-potential-role-of-fdg-pet-ct-in-the-characterization-of-the-activity-of-crohn-s-disease-staging-follow-up-and-prognosis-estimation-a-pilot-study
#13
Károly Palatka, Sándor Kacska, Szilvia Lovas, Ildikó Garai, József Varga, László Galuska
OBJECTIVES: FDG PET-CT is a global, noninvasive, sensitive method to determine the location and activity of inflammatory lesions. Segmental FDG uptake is proportional with immune cell infiltration of bowel. Our aim was to evaluate prospectively the role of PET in patients with active Crohn's disease (CD) before and after one year's biological therapy, and to compare simple endoscopic score for CD (SES-CD), CD activity index (CDAI) and global PET scores. We also analyzed the prognostic value of initial PET scores...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043859/gastrointestinal-bleeding-associated-with-chronic-excessive-use-overdosing-with-topical-ketoprofen-patch-in-elderly-patient
#14
Sakiko Hirose, Kana Matsuura, Hiroko Kato-Hayashi, Akio Suzuki, Koichi Ohata, Ryo Kobayashi, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu, Yoshinori Itoh
PURPOSE: Topical ketoprofen patch has been developed to reduce the risk of systemic adverse effects such as gastrointestinal injury and renal toxicity. MATERIALS AND METHODS: We reported here a case of lower intestinal bleeding associated with chronic excessive use of topical ketoprofen patch in an elderly patient. RESULTS: A 74-year-old female visited to the outpatient clinic of the Gifu University Hospital and admitted thereafter. She had fecal occult blood and anemia...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043711/the-many-guises-of-endometriosis-giant-abdominal-wall-endometriosis-masquerading-as-an-incisional-hernia
#15
Chiara Petrosellini, Sala Abdalla, Tayo Oke
Endometriosis is defined by the presence of ectopic endometrial tissue outside the uterine cavity. Although it is a leading cause of chronic pelvic pain and infertility, its clinical presentation can vary, resulting in diagnostic and therapeutic challenges. Extrapelvic endometriosis is particularly difficult to diagnose owing to its ability to mimic other conditions. Endometrial tissue in a surgical scar is uncommon and often misdiagnosed as a granuloma, abscess, or malignancy. Cyclical hemorrhagic ascites due to peritoneal endometriosis is exceptionally rare...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29043689/-mesenteric-edema-as-a-prenatal-ultrasound-sign-of-poor-prognosis-in-gastroschisis
#16
M Dore Reyes, P Triana Junco, J L Encinas Hernández, E Alvarado Antolín, J L Bartha Rasero, V Núñez Cerezo, M Romo Muñoz, M Gómez Cervantes, A Sánchez Galán, L Martínez Martínez, M López Santamaría
INTRODUCTION/AIM OF THE STUDY: Gastroschisis is a congenital malformation with an easy and early prenatal diagnosis, however, it has a variable post-natal outcome. Our aim was to determine if certain ultrasound markers or early delivery were related with a worse postnatal outcome. PATIENTS AND METHODS: Retrospective study of a cohort of patients with gastroschisis diagnosed between 2005-2014, with emphasis on prenatal ultrasounds, gestational age at delivery and post-natal outcome...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29043445/the-role-of-intermediate-filaments-in-maintaining-integrity-and-function-of-intestinal-epithelial-cells-after-massive-bowel-resection-in-a-rat
#17
I Sukhotnik, Y Ben Shahar, Y Pollak, T Dorfman, H Kreizman Shefer, Z E Assi, N Mor-Vaknin, A G Coran
PURPOSE: Intermediate filaments (IFs) are a part of the cytoskeleton that extend throughout the cytoplasm of all cells and function in the maintenance of cell-shape by bearing tension and serving as structural components of the nuclear lamina. In normal intestine, IFs provide a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features. The purpose of this study was to evaluate the role of IFs during intestinal adaptation in a rat model of short bowel syndrome (SBS)...
October 17, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29043404/epiploic-appendagitis-7-year-experience-and-relationship-with-visceral-obesity
#18
James P Nugent, Hugue A Ouellette, D Peter O'Leary, Faisal Khosa, Savvas Nicolaou, Patrick D McLaughlin
PURPOSE: Location, size, and local inflammatory findings in primary epiploic appendagitis (EA) have not been reported outside of small studies. The association between EA and increased adiposity is controversial. The goals of this project are to compare demographics and imaging-based measurements of adiposity between patients with EA and patients with acute abdomen without EA, and to identify CT features of EA. METHODS: A consecutive sample of acute, primary EA (n = 100), and control (acute abdomen; n = 100) was selected retrospectively...
October 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29039050/the-protective-effect-of-fish-oil-lipid-emulsions-on-intestinal-failure-associated-liver-disease-in-a-rat-model-of-short-bowel-syndrome
#19
Seiro Machigashira, Tatsuru Kaji, Shun Onishi, Waka Yamada, Keisuke Yano, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri
PURPOSE: Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis. METHODS: Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group)...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29035975/breath-hydrogen-testing-in-east-and-southeast-asia
#20
Chu Kion Yao, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Breath hydrogen tests are popular, noninvasive tests for the assessment of carbohydrate fermentation in patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). There is limited information regarding the utility of breath hydrogen and methane tests in IBS and FD patients in East and Southeast Asia. This review aims to summarize current literature about common indications of breath testing in this region, the genesis of functional gastrointestinal symptoms by provocative breath testing and provide suggestions for correct use...
October 13, 2017: Journal of Clinical Gastroenterology
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