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https://www.readbyqxmd.com/read/29693447/chronic-kidney-disease-uremic-milieu-and-its-effects-on-gut-bacterial-microbiota-dysbiosis
#1
Lee D Chaves, Daniel I McSkimming, Mark A Bryniarski, Amanda M Honan, Sham Abyad, Shruthi A Thomas, Steven Wells, Michael J Buck, Yijun Sun, Robert J Genco, Richard J Quigg, Rabi Yacoub
Several lines of evidence suggest that gut bacterial microbiota is altered in patients with chronic kidney disease (CKD), though the mechanism of which this dysbiosis takes place is not well understood. Recent studies delineated changes in gut microbiota in both CKD patients and experimental animal models using microarray chips. We present 16S ribosomal RNA gene sequencing of both stool pellets and small bowel contents of C57Bl/6J mice that underwent a remnant kidney model, and establish that changes in microbiota take place in the early gastrointestinal track...
April 25, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29693127/association-between-gastrointestinal-motility-and-macrophage-mast-cell-distribution-in-mice-during-the-healing-stage-after-dss%C3%A2-induced-colitis
#2
Mio Kodani, Hirokazu Fukui, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroto Miwa
Irritable bowel syndrome (IBS) frequently occurs after infectious colitis or inflammatory bowel disease in patients with complete remission. This suggests that post‑inflammation‑associated factors may serve a role in the pathophysiology of IBS; however, the mechanism responsible remains unclear. In the present study, the involvement of macrophages and mast cells in alteration of gastrointestinal (GI) motility was investigated in mice in the remission stage after acute colitis. C57BL/6 mice were administered 2% dextran sulfate sodium in drinking water for 5 days and their intestinal tissues were investigated at intervals for up to 24 weeks...
April 24, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29692603/inflammatory-bowel-disease-patients-prioritize-mucosal-healing-symptom-control-and-pain-when-choosing-therapies-results-of-a-prospective-cross-sectional-willingness-to-pay-study
#3
James C Gregor, Martin Williamson, Dorota Dajnowiec, Bernie Sattin, Erik Sabot, Baljinder Salh
Background: Given the large armamentarium of therapies for inflammatory bowel disease (IBD), physicians cannot fully describe all treatments to patients and, therefore, make assumptions regarding treatment attributes communicated to patients. This study aimed to assess out-of-pocket willingness-to-pay that IBD patients allocate to treatment attributes. Methods: Adult patients receiving therapy for IBD were invited to access a cross-sectional web-based discrete-choice experiment (May 22-August 31, 2015) that presented paired medication scenarios with varying efficacy, safety, and administration parameters...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29688470/diagnostic-accuracy-of-ultrasonography-in-the-detection-of-postsurgical-recurrence-in-crohn-s-disease-a-systematic-review-with-meta-analysis
#4
Antonio Rispo, Nicola Imperatore, Anna Testa, Olga Maria Nardone, Gaetano Luglio, Nicola Caporaso, Fabiana Castiglione
Background and aims: The postoperative course of Crohn's disease (CD) is best predicted by ileocolonoscopy. Ultrasonography (US) has been proposed as indicator for postsurgical recurrence (PSR), but further confirmation is needed. We performed a systemic review with meta-analysis to assess the pooled diagnostic accuracy of US in the evaluation of PSR. Methods: The systematic review was performed in PubMed/MEDLINE, EMBASE, SCOPUS, and Cochrane databases to identify studies assessing the US accuracy in PSR diagnosis...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688413/sex-related-differences-in-patients-with-inflammatory-bowel-disease-results-of-2-prospective-cohort-studies
#5
Mirjam Severs, Lieke M Spekhorst, Marie-Josée J Mangen, Gerard Dijkstra, Mark Löwenberg, Frank Hoentjen, Andrea E van der Meulen-de Jong, Marieke Pierik, Cyriel Y Ponsioen, Gerd Bouma, Janneke C van der Woude, Mirthe E van der Valk, Marielle J L Romberg-Camps, Cees H M Clemens, Paul van de Meeberg, Nofel Mahmmod, Jeroen Jansen, Bindia Jharap, Rinse K Weersma, Bas Oldenburg, Eleonora A M Festen, Herma H Fidder
Background: The understanding of gender differences in inflammatory bowel disease (IBD) patients is an important step towards tailored treatment for the individual patient. The aim of this study was to compare disease phenotype, clinical manifestations, disease activity, and healthcare utilization between men and women with Crohn's disease (CD) and ulcerative colitis (UC). Methods: Two multicenter observational cohort studies with a prospective design were used to explore the differences between men and women regarding demographic and phenotypic characteristics and healthcare utilization...
April 21, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29687907/proton-coupled-oligopeptide-transporter-1-pept1-function-regulation-and-influence-on-the-intestinal-homeostasis
#6
Britta Spanier, Florian Rohm
As the organ with one of the largest surface areas facing the environment and responsible for nutrient uptake, the small intestine expresses numerous transport proteins in its brush-border membrane for efficient absorption and supply of dietary macro- and micronutrients. The understanding of regulation and functional interplay of these nutrient transporters is of emerging interest in nutrition and medical physiology research in respect to development of diabetes, obesity, and inflammatory bowel disease worldwide...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29686835/atypical-presentation-of-meckel-s-diverticulum-in-a-hispanic-man-a-case-report
#7
Yohanis O'Neill, Hiram M Soler
The incidence of Meckel's diverticulum is 2% in the general population. Although most commonly found in children as painless rectal bleeding, in adults, obstruction, inflammation, and perforation are the usual manifestations. We present the case of a 32 year old man who arrived at our institution with hematochezia and symptomatic anemia. A large Meckel's diverticulum was encountered during work-up and treated by segmental small bowel resection. A literature review, including disease presentation, pathology findings, and treatment options is discussed...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29686795/rare-cause-of-gastric-outlet-obstruction
#8
Sonal Gandhi, Niraj Jani
Bouveret's syndrome is a rare cause of gastric outlet obstruction. The stones enter the small bowel via cholecysto-enteric fistula. The most common presenting symptoms are abdominal pain, nausea and vomiting. The gold standard diagnostic test isesophagogastroduodenoscopy (EGD). Rigler's triad on abdominal x-ray is classic. CT scan findings are pneumobilia, cholecystoduodenal fistula and a gallstone in the duodenum. We present a case of a 75-year-old female who presents with 3 week history of nausea, vomiting, and diffuse abdominal pain...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29686230/nomogram-based-prediction-of-rebleeding-in-small-bowel-bleeding-patients-the-prsbb-score
#9
Genta Uchida, Yoshiki Hirooka, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Masanobu Matsushita, Hiroki Suhara, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto
Small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE) have revolutionized the diagnosis and treatment of small bowel bleeding (SBB), allowing access to the small bowel and identification of specific bleeding lesions. However, some patients experience rebleeding after small bowel investigation, and there are no definitive algorithms for determining the most appropriate follow-up strategy in SBB patients. We developed and validated a nomogram that can predict rebleeding risk and be used to develop a risk-stratified follow-up strategy in SBB patients...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685785/validation-of-a-low-cost-do-it-yourself-model-for-neonatal-thoracoscopic-congenital-diaphragmatic-hernia-repair
#10
Pedro Reino-Pires, Manuel Lopez
OBJECTIVE: We aimed to develop and validate a low cost, do-it-yourself model for neonatal thoracoscopic congenital diaphragmatic hernia (CDH). DESIGN: Volunteers with varying skills in neonatal minimally invasive surgery tested and evaluated the model simulating a neonatal thoracoscopic CDH repair. The model was built from ordinary materials purchased in a dime store: a small food container, a neoprene band simulating a diaphragm, an inflated balloon simulating a spleen, a tissue chord simulating intestine, and a body wash sponge simulating a collapsed lung...
April 20, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29685526/paediatric-magnetic-resonance-enterography-in-inflammatory-bowel-disease
#11
Mary-Louise C Greer
Paediatric magnetic resonance enterography (MRE) has been increasingly employed in the evaluation of inflammatory bowel disease (IBD) in the past decade. This is in parallel with a global rise in paediatric-onset IBD, greater recognition of the hazards of ionizing radiation, especially in children, and improved treatment options. MRE is now the reference standard for assessing the small bowel in suspected or proven paediatric IBD, and is central to the diagnosis of Crohn's disease (CD), helping distinguish it from ulcerative colitis...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29685508/superior-mesenteric-artery-stenting-using-embolic-protection-device-for-treatment-of-acute-or-chronic-mesenteric-ischemia
#12
Bernardo C Mendes, Gustavo S Oderich, Tiziano Tallarita, Karina S Kanamori, Manju Kalra, Randall R DeMartino, Fahad Shuja, Jill K Johnstone
OBJECTIVE: The objective of the study was to report the feasibility and results of superior mesenteric artery (SMA) stenting using embolic protection devices (EPDs) to treat acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). METHODS: A retrospective review was conducted of consecutive patients who underwent SMA stenting with EPDs from 2007 to 2016. EPDs were used selectively in patients with occlusions, severe calcification, or acute thrombus...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29685344/bladder-scan-accuracy-in-pediatric-patients-does-patient-position-matter
#13
J M Zillioux, S T Corbett, E Hunter, N G Kern
INTRODUCTION: Despite its widespread use in pediatric urology clinics, portable bladder scanning is an insufficiently studied tool that lacks standardized protocols. Workflow at the present clinic can be impeded by scanning in the supine position, due to multiple trips to the restroom and back to the exam room. OBJECTIVE: The current study sought to test accuracy of bladder scanning, and hypothesized that it would be equally accurate in the standing versus traditional supine position in children, given the intra-abdominal location of their bladders...
March 31, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29684865/the-effect-of-fecal-microbiota-transplantation-on-psychiatric-symptoms-among-patients-with-irritable-bowel-syndrome-functional-diarrhea-and-functional-constipation-an-open-label-observational-study
#14
Shunya Kurokawa, Taishiro Kishimoto, Shinta Mizuno, Tatsuhiro Masaoka, Makoto Naganuma, Kuo-Ching Liang, Momoko Kitazawa, Moeko Nakashima, Chie Shindo, Wataru Suda, Masahira Hattori, Takanori Kanai, Masaru Mimura
BACKGROUNDS: The intestinal microbiota is considered as a potential common underpinning pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and psychiatric disorders such as depression and anxiety. Fecal Microbiota Transplantation (FMT) has been reported to have therapeutic effects on diseases related to dysbiosis, but few studies have evaluated its effect on psychiatric symptoms. METHODS: We followed 17 patients with either Irritable Bowel Syndrome (IBS), Functional Diarrhea (FDr) or Functional Constipation (FC) who underwent FMT for the treatment of gastrointestinal symptoms and observation of psychiatric symptoms...
April 12, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29684805/detecting-a-rare-composite-small-bowel-lymphoma-by-magnetic-resonance-imaging-coincidentally-a-case-report-with-radiological-surgical-and-histopathological-features
#15
M Pezzella, B Brogna, A Romano, F Torelli, G Esposito, M Petrillo, F M Romano, N Di Martino, A Reginelli, R Grassi
INTRODUCTION: Diagnosing lymphoma continues to prove challenging in the clinical practice. Composite lymphoma (CL) is defined by the coexistence of different lymphoma subtypes in the same anatomical location. This condition has seldom been witnessed in the gastrointestinal (GI) tract. We weren't able to find previous cases in the literature about small bowel CL with follicular lymphoma (FL) and classical Hodgkin lymphoma (CHL). Surgery is the treatment of choice to obtain accurate histology, to manage and prevent acute complications...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29683235/a-study-of-clinicopathologic-factors-as-indicators-for-early-prediction-of-suboptimal-debulking-surgery-after-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer
#16
Joo-Hyuk Son, Kyoungjin Chang, Tae-Wook Kong, Jiheum Paek, Suk-Joon Chang, Hee-Sug Ryu
AIM: This study aimed to evaluate early clinicopathologic factors predicting gross residual disease after neoadjuvant chemotherapy in patients with advanced epithelial ovarian cancer. METHODS: We analyzed clinicopathologic data of 68 patients with ovarian cancer who were treated with neoadjuvant chemotherapy followed by interval debulking surgery (NAC-IDS) between March 2006 and December 2016. All the patients received three cycles of NAC followed IDS. We evaluated all possible clinicopathologic characteristics, including reduction rates of serum CA-125 after each NAC and seven initial abdominopelvic computed tomography (CT) findings related to disease severity...
April 23, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29682720/-research-progress-of-sacral-neuromodulation-procedure-in-the-treatment-of-chronic-constipation-and-fecal-incontinence
#17
Chenxiang He, Shaoqing Liu, Shisen Li, Bo Zhang, Jianyong Zheng
Sacral neuromodulation(SNM) procedure has become a new therapy to treat chronic constipation and fecal incontinence. The surgical procedure is easy and safe. It has a small incision compared with traditional surgery and is mainly used in patients whose traditional treatment was unsuccessful. Chronic constipation is one of the most common digestive symptoms. The quality of life in patients with severe constipation has decreased greatly. Although the incidence of fecal incontinence in China is not as high as that of constipation, it also seriously affects the life of the patients, resulting in a decline in the quality of life...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682620/a-prospective-cohort-study-of-patient-reported-vomiting-retching-nausea-and-antiemetic-use-during-neoadjuvant-long-course-radiation-therapy-and-concurrent-5-fluorouracil-based-chemotherapy-for-rectal-adenocarcinoma
#18
Kristopher Dennis, Liang Zeng, Carlo De Angelis, Hans Chung, Natalie Coburn, Edward Chow, C Shun Wong
Background and purpose: Antiemetic guidelines suggest daily prophylaxis with a serotonin3 receptor antagonist (5-HT3 RA) as an option for patients receiving long-course neoadjuvant radiation therapy and concurrent 5-fluorouracil-based chemotherapy for rectal cancer, despite the risks that 5-HT3 RA-induced constipation may pose. We explored the incidence of patient-reported vomiting, retching, nausea and antiemetic intake among patients in this setting to determine if these risks are justified...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29682387/surgical-management-of-encapsulating-peritoneal-sclerosis-a-case-report-in-kidney-transplant-patient
#19
R Shahbazov, M Talanian, J L Alejo, F Azari, A Agarwal, K L Brayman
Introduction: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome of progressive fibrotic change in response to prolonged, repetitive, and typically severe insult to the peritoneal mesothelium, often occurring in the setting of peritoneal dialysis (PD). Clear guidelines for successful management remain elusive. We describe the successful surgical management of EPS in a 28-year-old male s/p deceased donor kidney transplant for end-stage renal disease (ESRD) secondary to focal segmental glomerulosclerosis (FSGS)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29681874/alexithymia-in-gastroenterology-and-hepatology-a-systematic-review
#20
Danilo Carrozzino, Piero Porcelli
Background: Alexithymia is a multifaceted personality construct that represents a deficit in the cognitive processing of emotions and is currently understood to be related to a variety of medical and psychiatric conditions. The present review aims to investigate the relationship of alexithymia with gastrointestinal (GI) disorders as functional gastrointestinal disorders (FGID, as irritable bowel syndrome (IBS) and functional dyspepsia) and inflammatory bowel disease (IBD) [ulcerative colitis (UC) and Crohn's disease (CD)] and liver diseases as chronic hepatitis C (CHC), cirrhosis, and liver transplantation...
2018: Frontiers in Psychology
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