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https://www.readbyqxmd.com/read/29456640/comparative-study-of-ultrasonic-elastography-and-conventional-ultrasound-in-diagnosis-of-malignant-anus-neoplasm
#1
Yicheng Zhu, Shuhao Deng, Yuan Zhang, Quan Jiang
The application value of conventional ultrasound and ultrasonic elastography (UE) in preoperative diagnosis and combined diagnosis of malignant anus neoplasms was investigated. One hundred and twenty patients, whose mass was detected by digital rectal examination, were examined using UE and conventional ultrasound before operation, and the results were compared with those of histopathological examinations after operation, so that the accuracy and imaging features of UE as well as UE combined with conventional ultrasound in diagnosing malignant anus neoplasm were analyzed...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29447025/anal-sphincter-dysfunction-in-patients-treated-with-primary-radiotherapy-for-anal-cancer-a-study-with-the-functional-lumen-imaging-probe
#2
Susanne Haas, Pia Faaborg, Donghua Liao, Søren Laurberg, Hans Gregersen, Lilly Lundby, Peter Christensen, Klaus Krogh
BACKGROUND: Sphincter-sparing radiotherapy or chemoradiation are standard treatments for patients with anal cancer. The ultimate treatment goal is full recovery from anal cancer with preserved anorectal function. Unfortunately, long-term survivors often suffer from severe anorectal symptoms. The aim of the present study was to characterize changes in anorectal physiology after radiotherapy for anal cancer. METHOD: We included 13 patients (10 women, age 63.4 ± 1...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29441419/modern-intensity-modulated-radiotherapy-with-image-guidance-allows-low-toxicity-rates-and-good-local-control-in-chemoradiotherapy-for-anal-cancer-patients
#3
Berardino De Bari, Laëtitia Lestrade, Alessandra Franzetti-Pellanda, Raphael Jumeau, Maira Biggiogero, Melpomeni Kountouri, Oscar Matzinger, Raymond Miralbell, Jean Bourhis, Mahmut Ozsahin, Thomas Zilli
PURPOSE: To report outcomes of a population of anal cancer patients treated with modern intensity-modulated radiotherapy and daily image-guided radiotherapy techniques. METHODS: We analyzed data of 155 patients consecutively treated with intensity-modulated radiotherapy +/- chemotherapy in three radiotherapy departments. One hundred twenty-two patients presented a stage II-IIIA disease. Chemotherapy was administered in 138 patients, mainly using mitomycin C and 5-fluorouracil (n = 81)...
February 13, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29432808/the-impact-of-naloxegol-on-anal-sphincter-function-using-a-human-experimental-model-of-opioid-induced-bowel-dysfunction
#4
Debbie Grønlund, Jakob L Poulsen, Klaus Krogh, Christina Brock, Donghua Liao, Hans Gregersen, Asbjørn M Drewes, Anne E Olesen
BACKGROUND AND AIMS: Opioid treatment interferes with anal sphincter function and its regulation during defecation. This may result in straining, incomplete evacuation, and contribute to opioid-induced bowel dysfunction (OIBD). Employing an experimental model of oxycodone-induced OIBD, we hypothesized that co-administration of the peripherally acting μ-opioid antagonist naloxegol would improve anal sphincter function in comparison to placebo. METHODS: In a double-blind randomized crossover trial, 24 healthy males were assigned to a six-day treatment of oral oxycodone 15 mg twice daily in combination with either oral naloxegol 25 mg once daily or placebo...
February 9, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29417869/a-biomechanical-model-of-the-human-defecatory-system-to-investigate-mechanisms-of-continence
#5
William E Stokes, David G Jayne, Ali Alazmani, Peter R Culmer
This article presents a method to fabricate, measure and control a physical simulation of the human defecatory system to investigate individual and combined effects of anorectal angle and sphincter pressure on continence. To illustrate the capabilities and clinical relevance of the work, the influence of a passive-assistive artificial anal sphincter (FENIXTM) is evaluated. A model rectum and associated soft tissues, based on geometry from an anonymised computed tomography dataset, was fabricated from silicone and showed behavioural realism to the biological system and ex vivo tissue...
February 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29411072/prospective-evaluation-of-the-safety-and-feasibility-of-a-pelvic-floor-dilator-during-active-labor
#6
Francisco J Orejuela, Rajshi Gandhi, Lauren Mack, Wesley Lee, Haleh Sangi-Haghpeykar, Hans P Dietz, Susan M Ramin
INTRODUCTION AND HYPOTHESIS: The objective was to assess the safety and feasibility of using a pelvic floor dilator during active labor to prevent injuries to the levator ani muscle (LAM) and perineum. METHODS: In a prospective pilot study, a pelvic floor dilator using soft pads was introduced into the vaginal canal to gradually expand the vagina, in 30 nulliparous women and in 10 controls. The primary outcomes were adverse events related to the device. Secondary outcomes were perineal lacerations after delivery, sonographically defined levator ani injury, hiatal area dimensions, and anal sphincter disruption, all at 12-20 weeks postpartum, and maximum pelvic floor dilation, time to achieve maximum dilation, and device retention rate...
February 6, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29400297/perianal-paget-disease-secondary-to-pagetoid-spread-of-mucinous-adenocarcinoma-of-the-anal-canal
#7
Eugénia Matos-Pires, Mário Oliveira, Alexandre João, Pedro Mendes-Bastos
No abstract text is available yet for this article.
February 1, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29394850/-multidisciplinary-treatment-for-squamous-cell-carcinoma-of-the-anal-canal
#8
Hideaki Karasawa, Shinobu Ohnuma, Kazuhiro Watanabe, Takahiro Tsuchiya, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
Chemoradiotherapy(CRT)has been recognized as a standard treatment for locoregional squamous cell carcinoma of the anal canal in Western countries. However, surgery had historically been considered as a standard treatment and there are only a few reports on CRT for anal canal cancer in Japan. In this study, we analyzed medical records of 5 anal canal cancer patients treated with CRT in our hospital between 2005 and 2015. Patients' characteristics were as follows: median age, 70 years (range 42-80 years); male/female, 1/4; and clinical Stage I / III a/ III b, 3/1/1...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394843/-a-case-of-anal-canal-cancer-with-skin-invasion-to-which-abdominoperineal-resection-and-perineum-reconstruction-were-performed-after-neoadjuvant-chemoradiotherapy
#9
Ayumi Yamaguchi, Masakazu Miyake, Sumiko Yoshitatsu, Mamoru Uemura, Masataka Ikeda, Takeshi Kato, Takuya Hamakawa, Sakae Maeda, Naoki Hama, Kazuhiro Nishikawa, Atsushi Miyamoto, Michihiko Miyazaki, Motohiro Hirao, Shoji Nakamori, Mitsugu Sekimoto
A 74-year-old man visited our hospital with an awareness of anal mass and bleeding. He was diagnosed as adenocarcino- ma of anal canal with wide spreading skin invasion. After neoadjuvant chemoradiotherapy(radiationtotal 45 Gy/25 Fr; cape- citabine 825mg/m2)was performed to reduce the mass volume, laparoscopic abdominoperineal resection with large perineum skin resection and lateral lymph node dissection was carried out. The perineal defect was repaired with a rectus abdominis musculocutaneous flap. Six days after surgery, the rectus abdominis musculocutaneous flap necrotized, and second perineum reconstruction by the bilateral gracilis musculocutaneous flaps was performed after debridement of necrotic tissue...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394724/-a-case-report-of-anal-canal-squamous-cell-carcinoma-with-poor-prognosis-that-occurred-nine-years-after-subtotal-colectomy-for-ulcerative-colitis
#10
Toshihiro Tajirika, Nobuhisa Matsuhashi, Takao Takahashi, Kazuhiro Yoshida
Ulcerative colitis(UC)is a chronic inflammatorydisease. Since it is known to be a risk factor for colorectal cancer, severe cases, refractorycases, or cases with cancer are often treated with surgery. We report a case of anal canal squamous cell carcinoma(SCC)found 9 years after subtotal colectomy for UC. A 32-year-old man underwent subtotal colectomyand ileorectum anastomosis 9 years ago for fulminant UC. Anemia was detected during treatment with infliximab, which was initiated 2 years ago. Endoscopic findings revealed a type 3 tumor at the anal canal in the anastomotic region, and he presented to our department...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394635/-abdominoperineal-resection-for-anal-metastasis-of-rectal-cancer
#11
Keishi Hakoda, Masanori Yoshimitsu, Manabu Emi, Yuya Hirai, Atsushi Kamigaichi, Manato Osawa, Norimasa Kuraoka, Toshiaki Komo, Norifumi Tsubokawa, Ichiko Yamakita, Masashi Miguchi, Yoshiro Aoki, Akira Nakashima, Mikihiro Kano, Koichi Oishi, Toshihiko Kohashi, Mayumi Kaneko, Mahito Funakoshi, Jun Hihara, Hidenori Mukaida, Naoki Hirabayashi
Anal metastasis of colorectal cancer is rare, and no standardized effective therapeutic strategy exists. We report a case of abdominoperineal resection for anal metastasis of rectal cancer. A 65-year-old man underwent laparoscopic low anterior resection for rectal cancer in August 2013. Histopathological examination revealed a moderately differentiated adenocarcinoma( tub2, pSS, ly3, v2, pN1, H0, P0, M0, Stage III a, Cur A). In February 2015, he complained of anal discomfort, and tumor markers were elevated...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394624/-a-case-report-of-adenocarcinoma-with-pagetoid-growth-secondary-paget-s-disease-of-the-anal-canal
#12
Wataru Okajima, Yoshiaki Kuriu, Tomohiro Arita, Yasutoshi Murayama, Masayoshi Nakanishi, Tokunari Okayama, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Differentiating primary Paget's disease from secondary Paget's disease, which is also known as Pagetoid growth of other cancers, in the perianal region is difficult. Given that the treatment strategies of both disease are significantly different, diagnosis of such conditions should be performed with caution. We report a case of secondary Paget's disease. A 76-year-old man previously visited a hospital because of erythematous plaque around the anus. It was diagnosed as extramammary Paget's disease based on skin biopsy results; consequently, perianal skin resection was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393674/target-volume-motion-during-anal-cancer-image-guided-radiotherapy-using-cone-beam-computed-tomography
#13
Corrinne J Brooks, Laurence Bernier, Vibeke N Hansen, Diana M Tait
OBJECTIVE: Literature regarding image-guidance and interfractional motion of the anal canal (AC) during anal cancer radiotherapy is sparse. This study investigates interfractional AC motion during anal cancer radiotherapy. METHODS: Bone matched cone-beam computed tomography (CBCT) images were acquired for 20 patients receiving anal cancer radiotherapy allowing population systematic and random error calculations. 12 were selected to investigate interfractional AC motion...
February 2, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29387509/anal-melanoma-in-an-elderly-woman-masquerading-as-hemorrhoid
#14
Gabriel O Ologun, Yuan Stevenson, Alice Shen, Navpreet K Rana, Amber Hussain, David Bertsch, Burt Cagir
Anal melanoma is a rare and aggressive neoplasm of the anal canal seen in the elderly population in the six or seventh decade of their lives. Presentation is usually nonspecific and diagnosis is often delayed or missed initially. The management is surgical and prognosis is poor. Here we present a case of anal melanoma in an elderly patient masquerading as hemorrhoid.
November 26, 2017: Curēus
https://www.readbyqxmd.com/read/29386209/when-a-wound-is-the-harbinger-of-a-serious-underlying-systemic-illness
#15
Shweta Kishore, Varun Mittal, Shradha Ahuja, Vikas Majithia
A 55-year-old woman presented with progressive enlarging and painful non-healing ulcers on her bilateral lower extremities; biopsy was consistent with pyoderma gangrenosum. Workup for an underlying illness revealed a cavitary lung nodule and an ulcerating mass in the anal canal. Patient did not have any respiratory or gastrointestinal symptoms. Differential diagnosis included inflammatory bowel disease, rectal carcinoma or infection such as tuberculosis, fungal process. Histopathology did not reveal any malignancy, inflammatory bowel disease or infection...
January 31, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29368903/-anesthesic-management-during-total-organic-separation-of-pygopagus-conjoined-twins
#16
Mayra Lizeth Nava-Martínez, Enriqueta Macias-Miranda, Karla Guadalupe Lozada-Rosete, Juan José Dosta-Herrera
BACKGROUND: Conjoined twins are among the most rare and challenging congenital malformations. The incidence varies from 1:30 000 to 1:200 000 live births. Pygopagus twins account for about 10 to 18% of all conjoined twins. CLINICAL CASE: We report the case of male conjoined pygopagus twins. They shared medullary canal, anal canal and sacrococcygeal region, without any degree of cross circulation. At the moment of the surgery, twin 1 had congenital heart disease without medical treatment...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29362310/-a-case-of-anal-canal-squamous-cell-carcinoma-detected-with-anal-stenosis-eight-years-following-resection-for-rectal-adenocarcinoma
#17
Takashi Fukao, Tomoko Matsumoto, Shiho Kuriyama, Tomohiro Toji, Yutaka Hirano, Yasuyuki Ohtawa, Toshihiko Waku, Kazuhiro Washio
An 89-year-old woman underwent low anterior resection for rectal adenocarcinoma(Ra, pT3N0M0, pStage II , Cur A)in 2008. In February 2016, she underwent an outpatient examination because of a defecation disturbance. Lower gastrointestinal endoscopy was performed and the stenotic region was biopsied. However, no malignancy was detected and the stenotic site expanded. However, the patient experienced recurrence of the same symptoms, developed severe anal stenosis, and underwent another examination in December 2016...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29345097/the-diagnostic-value-of-the-functional-lumen-imaging-probe-versus-high-resolution-anorectal-manometry-in-patients-with-fecal-incontinence
#18
A M Leroi, C Melchior, C Charpentier, V Bridoux, C Savoye-Collet, E Houivet, P Ducrotté, G Gourcerol
BACKGROUND: The functional lumen imaging probe (EndoFLIP® ) is a new technology that measures the distensibility of the anal canal represented by the anal distensibility index. The aims of this study were (i) to compare the anal distensibility index to anal pressure in a cohort of patients with fecal incontinence (FI) and (ii) to compare the diagnostic value of the EndoFLIP® to that of high-resolution anorectal manometry (HRAM) in the same cohort of patients. METHODS: Eighty-three consecutive patients with FI who underwent EndoFLIP® and HRAM assessments were enrolled...
January 18, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29340993/laparoscopic-assisted-modified-intersphincter-resection-for-ultralow-rectal-cancer
#19
Haiyang Zhou, Canping Ruan, Zhiguo Wang, Zhiqian Hu
BACKGROUND: Intersphincter resection (ISR) is considered to be a superior technique offering sphincter preservation in patients with ultralow rectal cancer.1 Because high-definition laparoscopy offers wider and clearer vision into the narrow pelvic cavity and intersphincteric space, ISR has been further refined.2 However, functional outcome after ISR has not been optimal. More than half of patients receiving ISR suffer partial or even complete anal incontinence.3 We therefore propose a laparoscopic-assisted modified ISR, with the aim of improving sphincter function following ISR...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29334527/transanal-minimally-invasive-anal-canal-polyp-resection
#20
Giovanni Dapri, Anny Cadenas Fabres, Olivier Nicod, Garces Duran Rodrigo, Vinciane Muls, Marc Van Gossum
Endoscopic mucosal resection and endoscopic submucosal dissection (ESD) are operative endoscopies that have been performed since a long time. Recently, an evolution of laparoscopy called transanal minimally invasive surgery began to be popularized, and it can be adopted in the face of difficult cases for endoscopic mucosal resection/ESD. In this video, a 36-year-old woman was submitted to transanal minimally invasive surgery resection, after unsuccessful ESD, for a 2-cm polyp located anteriorly in the anal canal, just beyond the pectineal line...
January 12, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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