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https://www.readbyqxmd.com/read/29049547/management-of-stage-i-squamous-cell-carcinoma-of-the-anal-canal
#1
Christy Y Chai, Hop Tran Cao, Samir Awad, Nader N Massarweh
Importance: The incidence of squamous cell carcinoma of the anal canal (SCCAC) is increasing. Although standard management of SCCAC includes the use of concurrent chemotherapy and radiotherapy (chemoradiotherapy), data are lacking on potentially less morbid, alternative management strategies, such as local excision, among patients with node-negative T1 disease. Objectives: To examine the use of local excision among patients with T1 SCCAC and to compare overall survival relative to those who received standard treatment with chemoradiotherapy...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29034437/management-of-early-anal-cancer-need-for-guidelines-and-standardisation
#2
Michael P Jones, Susan Carroll, Jarad Martin, Richard Hillman, Andrew Grulich, Dianne O'Connell, Christopher Young, Isobel Mary Poynten
PURPOSE: The optimal management of early squamous cell carcinoma of the anal canal (AC) is yet to be determined. This study investigated current practice in the management of early AC. METHODS: A patterns of care survey was completed by Australian surgeons and radiation oncologists. Specific topics addressed were as follows: geographical location of practice, staging of disease, treatment approaches to T1N0 tumours and grade 3 anal intra-epithelial neoplasia (AIN3) lesions, radiotherapy planning, toxicities, follow-up and clinical trial involvement...
October 15, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28994873/anal-imperforation-in-adults-diagnostic-difficulties-and-therapeutic-options
#3
Houcine Maghrebi, Rachid Ksantini, Amin Makni, Helmi Slama, Meriem Jrad, Amine Daghfous, Wael Rebai, Fadhel Fteriche, Faouzi Chebbi, Mohamed Jouini, Kacem Montassar, Zoubeir Ben Safta
Anorectal malformations are congenital anomalies ranging from simple perineal fistulas to complex malformations. They are usually treated inchildhood, and exceptionally in adult. We herein report the case of a 22 years aged patient and relate the diagnosis difficulties and therapeuticoptions. She consulted for anal imperforation discovered since birth. Initially, His parents refused the surgical management. It was an analimperforation with a vestibular fistula. The patient was operated by a low approach. She had a disconnection of the recto-vestibular fistula,dissection of the anal canal and a perineal posterior transposition...
November 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28986667/prolonged-release-oxycodone-naloxone-improves-anal-sphincter-relaxation-compared-to-oxycodone-plus-macrogol-3350
#4
Jakob Lykke Poulsen, Christina Brock, Debbie Grønlund, Donghua Liao, Hans Gregersen, Klaus Krogh, Asbjørn Mohr Drewes
BACKGROUND: Opioid analgesics inhibit anal sphincter function and contribute to opioid-induced bowel dysfunction (OIBD). However, it is unknown whether the inhibition can be reduced by opioid antagonism with prolonged-release (PR) naloxone and how this compares to laxative treatment. AIMS: To compare the effects of combined PR oxycodone/naloxone or PR oxycodone plus macrogol 3350 on anal sphincter function and gastrointestinal symptoms. METHODS: A randomized, double-blind, crossover trial was conducted in 20 healthy men...
November 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28982899/transanal-assisted-resection-with-closure-of-anal-canal-for-lower-rectal-diseases
#5
Hidejiro Kawahara, Tadashi Akiba, Katsuhiko Yanaga
BACKGROUND/AIM: Abdominoperineal resection (APR) has been performed for lower rectal cancer, anal cancer and inflammatory diseases, but is associated with postoperative complications such as inflammation of pelvic dead space or perineal wound infection. We are performing a novel procedure (transanal assisted resection with closure of anal canal, TARC) that resects the intestine by using transanal assist and close the anal canal for patients who do not require resection of the anus and anal canal...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28978604/oxaliplatin-induced-posterior-reversible-encephalopathy-syndrome-pres
#6
Taimoor Khalid Janjua, Muhammad Hassan, Hira Khan Afridi, Naila Anjum Zahid
Posterior reversible encephalopathy syndrome (PRES), first introduced in 1996, is a neurotoxic state characterised by seizures, headache, vision change, paresis, nausea and altered mental status. Risk factors include hypertension, eclampsia/pre-eclampsia, infection/sepsis and cancer chemotherapy. Although exposure to toxic agents is a common occurrence in patients who develop PRES, oxaliplatin has rarely been associated with it, with only 10 cases reported worldwide. We present the case of an oxaliplatin-induced PRES in a 23-year-old male patient who was started on oxaliplatin/capecitabine as adjuvant chemotherapy for anal canal adenocarcinoma...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28976027/underwater-endoscopic-mucosal-resection-of-an-intramucosal-carcinoma-located-from-the-lower-rectum-to-the-anal-canal
#7
Kenta Hamada, Noriya Uedo, Hitoshi Tanishita
A 62-year-old man with chronic renal failure was referred to our hospital for rectal polyp removal. Colonoscopy showed a 12-mm 0-Is+IIa lesion located from the lower rectum to the anal canal (Fig. 1a, b). The lesion looked small (<2 cm) and mostly benign. This article is protected by copyright. All rights reserved.
October 4, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28972796/pet-imaging-in-anal-canal-cancer-a-systematic-review-and-meta-analysis
#8
Aamer Mahmud, Raymond Poon, Derek Jonker
OBJECTIVE: The aim of this study was to systematically review the literature to synthesize and summarize the evidence surrounding the clinical utility of positron emission tomography (PET) imaging in patients with anal canal cancer. METHODS: The literature was searched using MEDLINE, EMBASE and Cochrane Database of Systematic Reviews databases. Studies comparing PET or PET/CT with conventional imaging in the staging, response evaluation, and follow-up of anal canal cancer were deemed eligible for inclusion...
October 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28959428/coincidence-or-not-a-rare-case-of-rectal-leiomyosarcoma-amidst-incidental-findings-of-anal-squamous-cell-carcinoma-case-presentation-and-literature-review
#9
Gosta Iwasiuk, Jason Nealy
Leiomyosarcoma accounts for only a small percentage of colorectal malignancies and remains a difficult disease to diagnose and treat. Here, we describe a case of leiomyosarcoma in a middle-age female first identified on colonoscopy. The cancer had invaded the posterior vaginal wall necessitating an abdominoperineal resection with partial vaginectomy and pelvic floor reconstruction with neovagina creation. Final pathologic analysis revealed invasion into the posterior vaginal wall without direct involvement of the vaginal squamous mucosa...
September 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28950040/fecal-incontinence-in-patients-with-spina-bifida-the-target-is-the-rectum
#10
Charlène Brochard, Alain Ropert, Benoît Peyronnet, Hélène Ménard, Andréa Manunta, Michel Neunlist, Guillaume Bouguen, Laurent Siproudhis
AIMS: The prevalence rate of severe fecal incontinence (FI) in adults with spina bifida (SB) is high. The physiological basis of FI in SB has not been clearly established, which contributes to inadequate care. The aim was to better characterize a large cohort of adults with special consideration of anorectal physiology. METHODS: A multidisciplinary team from a French referral centre for SB prospectively collected data on patients who had an anorectal manometry. Factors associated with severe FI (Cleveland clinical incontinence score ≥ 9) were assessed in a multivariate analysis model...
September 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28948325/prognostic-and-predictive-clinicopathologic-factors-of-squamous-anal-canal-cancer-in-hiv-positive-and-hiv-negative-patients-does-haart-influence-outcomes
#11
Emmanouil P Pappou, Jonathan T Magruder, Tao Fu, Caitlin W Hicks, Joseph M Herman, Sandy Fang, Elizabeth C Wick, Bashar Safar, Susan L Gearhart, Jonathan E Efron
BACKGROUND: The incidence of squamous cell carcinoma (SCC) of the anal canal has been rising over the past decades, especially in patients infected with human immunodeficiency virus (HIV). Despite the advent of potent multidrug regimens to treat HIV-termed highly active antiretroviral therapy (HAART), anal SCC rates have not declined, and the impact of HAART on anal SCC remains controversial. AIM: The purpose of this study was to define outcomes of anal SCC treatment in HIV-positive and HIV-negative patients...
September 25, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28945890/treatment-of-squamous-cell-carcinoma-of-the-anal-canal-scca-a-new-era
#12
A Casadei Gardini, M Valgiusti, A Passardi, G L Frassineti
No abstract text is available yet for this article.
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28941931/the-anal-canal-is-the-fine-line-between-fecal-incontinence-and-colitis-after-a-pull-through-for-hirschsprung-disease
#13
Luis De la Torre, Kimberly Cogley, Karla Santos, Otto Morales, Juan Calisto
BACKGROUND/PURPOSE: Fecal incontinence after a pull-through is associated with different factors, although damage to the anal canal seems to be the most important. The objective of this article is to identify the variables related to the presence of fecal control and colitis in a homogeneous group of children after pull-through. METHODS: A retrospective cross-sectional study was performed in patients with HD for evaluation of post-operative problems from May 2014 to November 2016...
September 4, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28936381/anal-canal-gas-gangrene-in-aplastic-anaemia-rare-yet-lethal-entity-a-caveat
#14
Sundaramurthi Sudharsanan, Chellappa Vijayakumar, Kumar Manish, T P Elamurugan, Ali S Manwar
Gas gangrene is one of the most serious infections of traumatic and surgical wounds. The importance lies in the fact that, if not managed at the right time, the condition is fatal. Though perianal cellulitis and gangrene are commonly reported in immunocompromised patients, we report the case of a patient with gas gangrene involving only the anal canal extending to the rectum, a rare presentation to be reported in literature.  An 18-year-old lady, a patient of aplastic anaemia - immunodeficiency, developed gas gangrene of the anal canal possibly due to faecal contamination of anal fissures...
July 13, 2017: Curēus
https://www.readbyqxmd.com/read/28922462/vaginal-mesh-repair-systems-for-pelvic-organ-prolapse-anatomical-study-comparing-transobturator-trangluteal-versus-single-incision-techniques
#15
Giuseppe Campagna, Giovanni Panico, Andrea Morciano, Pierre Gadonneix, Vincent Delmas, Mauro Cervigni, Alfredo Ercoli, Giovanni Scambia
INTRODUCTION: The present study aim to compare the anatomic landmarks of two pelvic floor repair systems, in order to identify the potential neurovascular lesions related to different mesh fixation techniques. METHODS: Abdominal and perineal dissections of 10 fresh cadavers after prolapse surgery using transobturator/transgluteal versus single incision techniques. Neuro-vascular structures of obturator region and perineum were isolated. Distances between needles and anatomical structures were measured...
September 18, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28906006/prevalence-of-anal-oral-penile-and-urethral-human-papillomavirus-in-hiv-infected-and-hiv-uninfected-men-who-have-sex-with-men
#16
Claudio Ucciferri, Manuela Tamburro, Katia Falasca, Michela Lucia Sammarco, Giancarlo Ripabelli, Jacopo Vecchiet
Aims of the study were to evaluate Human Papillomavirus (HPV) and type-specific prevalence in four anatomical sites in HIV infected men who have sex with men (MSM) compared with HIV uninfected MSM. Participants were recruited among the attendees of Infectious Diseases Clinics in Central Italy. A trained medical practitioner collected by interview sociodemographic data and information on medical history, sexual behavior and drug use. Swabs from anal canal, oral cavity, urethral mucosa and coronal sulcus were tested for HPV DNA and genotyping...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28905805/a-novel-model-of-acellular-dermal-matrix-plug-for-anal-fistula-treatment-report-of-a-case-and-surgical-consideration-based-on-first-utility-in-poland
#17
Adam Bobkiewicz, Łukasz Krokowicz, Maciej Borejsza-Wysocki, Tomasz Banasiewicz
Anal fistula (AF) is a pathological connection between anus and skin in its surroundings. The main reason for the formation of anal fistula is a bacterial infection of the glands within the anal crypts. One of the modern techniques for the treatment of fistulas that do not interfere with the sphincters consists in implantation of a plug made from collagen material. We are presenting the first Polish experience with a new model of biomaterial plug for the treatment of anal fistula. We also point out key elements of the procedure (both preoperative and intraoperative) associated with this method...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28883698/hypothesized-summative-anal-physiology-score-correlates-but-poorly-predicts-incontinence-severity
#18
Christopher J Young, Assad Zahid, Cherry E Koh, Jane M Young
AIM: To explore the relationship between such a construct and an existing continence score. METHODS: A retrospective study of incontinent patients who underwent anal physiology (AP) was performed. AP results and Cleveland Clinic Continence Scores (CCCS) were extracted. An anal physiology score (APS) was developed using maximum resting pressures (MRP), anal canal length (ACL), internal and external sphincter defects and pudendal terminal motor latency. Univariate associations between each variable, APS and CCCS were assessed...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28882511/-doses-to-organs-at-risk-for-conformational-and-stereotactic-radiotherapy-bladder
#19
REVIEW
L Duvergé, J Castelli, T Lizée, R de Crevoisier, D Azria
Bladder dose constraints in case of conformational radiotherapy/intensity-modulated radiotherapy and stereotactic radiotherapy are reported from the literature, in particular from the French radiotherapy society RECORAD recommendations, according to the treated pelvic tumor sites. The dose-volume effect on urinary toxicity is not clearly demonstrated, making difficult to establish absolute dose constraints for the bladder. In case of high-dose prostate cancer radiotherapy, the bladder dose constraints are: V60Gy<50% and maximum dose<80Gy for standard fractionation and V60Gy<5%, V48Gy<25% and V41Gy<50% for moderate hypofractionation (20 fractions of 3Gy)...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28871380/mri-of-anal-canal-common-anal-and-perianal-disorders-beyond-fistulas-part-2
#20
REVIEW
Ayşe Erden
A broad spectrum of disease, from benign processes to life-threatening pathologies, can cause anal pain. MR imaging (MRI) has become increasingly widely used method over the past two decades for the evaluation of individuals with anorectal symptoms. Although imaging is rarely necessary to determine the etiology of the majority of cases, MRI is particularly useful as a noninvasive method of excluding severe neoplastic conditions. In this article, MRI findings of a number of pathologies such as anal and perianal neoplasms, hemorrhoidal disease, arteriovenous malformation of the perianal region, and anal sphincter lesions (defects, scarring, atrophy) which may lead to fecal incontinence are presented...
September 4, 2017: Abdominal Radiology
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