keyword
https://read.qxmd.com/read/38492634/notoginsenoside-r1-targets-ppar-%C3%AE-to-inhibit-hepatic-stellate-cell-activation-and-ameliorates-liver-fibrosis
#21
JOURNAL ARTICLE
Cheng Guo, Linying Lai, Boyu Ma, Qian Huang, Zhirong Wang
BACKGROUND: Hepatic fibrosis, a common pathological process that occurs in end-stage liver diseases, is a serious public health problem and lacks effective therapy. Notoginsenoside R1 (NR1) is a small molecule derived from the traditional Chinese medicine Sanqi, exhibiting great potential in treating diverse metabolie disorders. Here we aimed to enquired the role of NR1 in liver fibrosis and its underlying mechanism in hepatoprotective effects. METHODS: We investigated the anti-fibrosis effects of NR1 using CCl4 -induced mouse mode of liver fibrosis as well as TGF-β1-activated JS-1, LX-2 cells and primary hepatic stellate cells...
March 14, 2024: Experimental Cell Research
https://read.qxmd.com/read/38491114/plasma-extracellular-vesicle-micrornas-reflecting-the-therapeutic-effect-of-the-cbp-%C3%AE-catenin-inhibitor-pri-724-in-patients-with-liver-cirrhosis
#22
JOURNAL ARTICLE
Mayu Yoshida, Juntaro Matsuzaki, Koji Fujita, Masamichi Kimura, Tomohiro Umezu, Noi Tokuda, Tomoko Yamaguchi, Masahiko Kuroda, Takahiro Ochiya, Yoshimasa Saito, Kiminori Kimura
There is an unmet need for antifibrotic therapies to prevent the progression of liver cirrhosis. Previously, we conducted an exploratory trial to assess the safety and antifibrotic efficacy of PRI-724, a selective CBP/β-catenin inhibitor, in patients with liver cirrhosis. PRI-724 was well tolerated and exerted a potential antifibrotic effect. Here, we investigated whether the profiles of circulating microRNAs packaged in extracellular vesicles (EV-miRNAs) are associated with responses to liver fibrosis treatments...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38489890/paeoniflorin-promotes-ppar%C3%AE-expression-to-suppress-hscs-activation-by-inhibiting-ezh2-mediated-histone-h3k27-trimethylation
#23
JOURNAL ARTICLE
Tian Lan, Ping Li, Si-Jia Zhang, Shi-Yu Liu, Xi-Xi Zeng, Fang Chai, Yu-Hua Tong, Zhu-Jun Mao, Si-Wei Wang
BACKGROUND: The alleviating effect of paeoniflorin (Pae) on liver fibrosis has been established; however, the molecular mechanism and specific target(s) underlying this effect remain elusive. PURPOSE: This study was to investigate the molecular mechanism underlying the regulatory effect of Pae on hepatic stellate cells (HSCs) activation in liver fibrosis, with a specific focus on the role of Pae in modulating histone methylation modifications. METHODS: The therapeutic effect of Pae was evaluated by establishing in vivo and in vitro models of carbon tetrachloride (CCl4 )-induced mice and transforming growth factor β1 (TGF-β1 )-induced LX-2 cells, respectively...
February 24, 2024: Phytomedicine
https://read.qxmd.com/read/38489889/jaceosidin-attenuates-the-progression-of-hepatic-fibrosis-by-inhibiting-the-vgll3-hmgb1-tlr4-signaling-pathway
#24
JOURNAL ARTICLE
Youli Yao, Xiaoling Zuo, Feng Shao, Kexin Yu, Quanquan Liang
BACKGROUND: Jaceosidin (JA) is a natural flavone extracted from Artemisia that is used as a food and traditional medicinal herb. It has been reported to possess numerous biological activities. However, the regulatory mechanisms underlying amelioration of hepatic fibrosis remain unclear. HYPOTHESIS/PURPOSE: We hypothesized that jaceosidin acid (JA) modulates hepatic fibrosis and inflammation. METHODS: Thioacetamide (TAA) was used to establish an HF mouse model...
March 10, 2024: Phytomedicine
https://read.qxmd.com/read/38485281/lx-2-stellate-cells-are-a-model-system-for-investigating-the-regulation-of-hepatic-vitamin-a-metabolism-and-respond-to-tumor-necrosis-factor-alpha-and-interleukin-1-beta
#25
JOURNAL ARTICLE
Lindsay C Czuba, Nina Isoherranen
Hepatic stellate cells (HSC) are the major site of vitamin A (retinol) esterification and subsequent storage as retinyl esters within lipid droplets. However, retinyl esters become depleted in many pathophysiological states, including acute and chronic liver injuries. Recently, using a liver slice culture system as a model of acute liver injury and fibrogenesis, a time-dependent increase and decrease in the apparent formation of the bioactive retinoid all- trans -retinoic acid ( at RA) and retinyl palmitate was measured, respectively...
March 14, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/38484149/cd44-expression-on-murine-hepatic-stellate-cells-promotes-the-induction-of-monocytic-and-polymorphonuclear-myeloid-derived-suppressor-cells
#26
JOURNAL ARTICLE
Julia Hagenstein, Simon Burkhardt, Paulina Sprezyna, Elena Tasika, Gisa Tiegs, Linda Diehl
In chronic inflammation regulatory immune cells, such as regulatory T cells and myeloid-derived suppressor cells (MDCS) can develop. Local signals in the inflamed tissue, such as cytokines and eicosanoids, but also contact dependent signals, can promote MDSC development. In the liver, hepatic stellate cells (HSC) may provide such signals via the expression of CD44. MDSC generated in the presence of HSC and anti-CD44 antibodies were functionally and phenotypically analyzed. We found that both monocytic (M-) and polymorphonuclear (PMN-) MDSC generated in the presence of αCD44 antibodies were less suppressive towards T cells as measured by T cell proliferation and cytokine production...
March 14, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38481992/machine-learning-and-experimental-validation-identified-autophagy-signature-in-hepatic-fibrosis
#27
JOURNAL ARTICLE
Yushen Huang, Wen Luo, Zhijie Yang, Tian Lan, Xiaomou Wei, Hongwen Wu
BACKGROUND: The molecular mechanisms of hepatic fibrosis (HF), closely related to autophagy, remain unclear. This study aimed to investigate autophagy characteristics in HF. METHODS: Gene expression profiles (GSE6764, GSE49541 and GSE84044) were downloaded, normalized, and merged. Autophagy-related differentially expressed genes (ARDEGs) were determined using the limma R package and the Wilcoxon rank sum test and then analyzed by GO, KEGG, GSEA and GSVA. The infiltration of immune cells, molecular subtypes and immune types of healthy control (HC) and HF were analyzed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38479138/impact-of-fine-particulate-matter-on-liver-injury-evidence-from-human-mice-and-cells
#28
JOURNAL ARTICLE
Yalan Xiao, Jialu Hu, Renjie Chen, Yanyi Xu, Bin Pan, Ya Gao, Yiran Deng, Wenshu Li, Haidong Kan, She Chen
BACKGROUND: A recently discovered risk factor for chronic liver disease is ambient fine particulate matter (PM2.5 ). Our research aims to elucidate the effects of PM2.5 on liver injury and the potential molecular mechanisms. METHODS AND RESULTS: A population-based longitudinal study involving 102,918 participants from 15 Chinese cities, using linear mixed-effect models, found that abnormal alterations in liver function were significantly associated with long-term exposure to PM2...
March 4, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38477077/lysine-specific-demethylase-1-inhibits-sodium-arsenite-activation-of-hscs-by-regulating-sesn2-ampk-ulk1-signaling-pathway-activity
#29
JOURNAL ARTICLE
Yingwan Zhang, Tian Tian, Cai Liang, Junli Wang, Jiayuan Zhang, Shanshan Tian, Rujia Xie, Ting Yang, Bing Han
Lysine specific demethylase 1 (LSD1) is a histone demethylase that specifically catalyzes the demethylation of histone H3K4 (H3K4me1/2) and regulates gene expression. In addition, it can mediate the process of autophagy through its demethylase activity. Sestrin2 (SESN2) is a stress-induced protein and a positive regulator of autophagy. In NaAsO2 -induced mouse fibrotic livers and activated hepatic stellate cells (HSCs), LSD1 expression is decreased, SESN2 expression is increased, and autophagy levels are also increased...
March 13, 2024: Environmental Toxicology
https://read.qxmd.com/read/38474368/synergistic-hepatoprotective-effects-of-mesenchymal-stem-cells-and-platelet-rich-plasma-in-a-rat-model-of-bile-duct-ligation-induced-liver-cirrhosis
#30
JOURNAL ARTICLE
Shivaraju Shivaramu, Swapan Kumar Maiti, Shajahan Amitha Banu, Elangovan Kalaiselvan, Khan Sharun, Mamta Mishra, Divya Mohan, Sangeetha Palakkara, Sunil Kumar, Monalisa Sahoo, Jürgen Hescheler
Liver cirrhosis poses a global health challenge marked by significant prevalence and mortality. Current therapeutic options are limited by high costs and immune-mediated rejection, necessitating the exploration of innovative strategies to enhance hepatic self-rehabilitation, and counteract the underlying pathological mechanisms. We evaluated the hepatoprotective activity of rat adipose-derived mesenchymal stem cells (ADMSCs) in combination with platelet-rich plasma (PRP) and recombinant human hepatocyte growth factor (rh-HGF) on a rat model of liver fibrosis/cirrhosis induced by bile duct ligation (BDL)...
February 26, 2024: Cells
https://read.qxmd.com/read/38473980/the-upregulation-of-leucine-rich-repeat-containing-1-expression-activates-hepatic-stellate-cells-and-promotes-liver-fibrosis-by-stabilizing-phosphorylated-smad2-3
#31
JOURNAL ARTICLE
Yake Wang, Xiaolong Li, Xiaowen Guan, Zhe Song, Huanfei Liu, Zhenzhen Guan, Jianwei Wang, Lina Zhu, Di Zhang, Liang Zhao, Peitong Xie, Xiaoyi Wei, Ning Shang, Ying Liu, Zhongzhen Jin, Zhili Ji, Guifu Dai
Liver fibrosis poses a significant global health risk due to its association with hepatocellular carcinoma (HCC) and the lack of effective treatments. Thus, the need to discover additional novel therapeutic targets to attenuate liver diseases is urgent. Leucine-rich repeat containing 1 (LRRC1) reportedly promotes HCC development. Previously, we found that LRRC1 was significantly upregulated in rat fibrotic liver according to the transcriptome sequencing data. Herein, in the current work, we aimed to explore the role of LRRC1 in liver fibrosis and the underlying mechanisms involved...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472011/danhongqing-formula-alleviates-cholestatic-liver-fibrosis-by-downregulating-long-non-coding-rna-h19-derived-from-cholangiocytes-and-inhibiting-hepatic-stellate-cell-activation
#32
JOURNAL ARTICLE
Meng Li, Yang Zhou, Hui Zhu, Lie-Ming Xu, Jian Ping
OBJECTIVE: This study explores the mechanism of action of Danhongqing formula (DHQ), a compound-based Chinese medicine formula, in the treatment of cholestatic liver fibrosis. METHODS: In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout (Mdr2-/- ) mice as an animal model of cholestatic liver fibrosis. DHQ was administered orally for 8 weeks, and its impact on cholestatic liver fibrosis was evaluated by assessing liver function, liver histopathology, and the expression of liver fibrosis-related proteins...
March 9, 2024: Journal of Integrative Medicine
https://read.qxmd.com/read/38471602/lichen-pectin-containing-polysaccharide-from-xanthoria-elegans-and-its-ability-to-effectively-protect-lx-2-cells-from-h-2-o-2-induced-oxidative-damage
#33
JOURNAL ARTICLE
Zheng Zhou, Guoqiang Li, Liang Gao, Yubi Zhou, Yuancan Xiao, Hongtao Bi, Hongxia Yang
Xanthoria elegans, a drought-tolerant lichen, is the original plant of the traditional Chinese medicine "Shihua" and effectively treats a variety of liver diseases. However, thus far, the hepatoprotective effects of polysaccharides, the most important chemical constituents of X. elegans, have not been determined. The aim of this study was to screen the polysaccharide fraction for hepatoprotective activity by using free radical scavenging assays and a H2 O2 -induced Lieming Xu-2 cell (LX-2) oxidative damage model and to elucidate the chemical composition of the bioactive polysaccharide fraction...
March 10, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38471319/esculin-inhibits-hepatic-stellate-cell-activation-and-ccl-4-induced-liver-fibrosis-by-activating-the-nrf2-gpx4-signaling-pathway
#34
JOURNAL ARTICLE
Shuoxi Xu, Yonger Chen, Jindian Miao, Yuhua Li, Jiaying Liu, Jing Zhang, Jian Liang, Shuxian Chen, Shaozhen Hou
BACKGROUND: Liver fibrosis (LF) is a pathological process of the liver that threatens human health. Currently, effective treatments are still lacking. Esculin, a prominent constituent found in the Fraxinus rhynchophylla. (bark), Aesculus hippocastanum. (bark), and Cichorium intybus. (herb), has been shown to possess significant anti-inflammatory, antioxidant, and antibacterial properties. However, to date, there have been no studies investigating its potential efficacy in the treatment of LF...
February 17, 2024: Phytomedicine
https://read.qxmd.com/read/38471267/stub1-increases-adiponectin-expression-by-inducing-ubiquitination-and-degradation-of-nr2f2-thereby-reducing-hepatic-stellate-cell-activation-and-alleviating-non-alcoholic-fatty-liver-disease
#35
JOURNAL ARTICLE
Zheng Mao, Jindong Zhao, Fan Cui, Zhen Li, Jinjin Cao, Jingjing Zhou, Mingliang Hou, Zengkun Qian
BACKGROUND: Adiponectin (APN) has exhibited ameliorating effects on non-alcoholic fatty liver disease (NAFLD). This study investigates the roles of APN and its regulatory molecules in hepatic stellate cell (HSC) activation and the progression of NAFLD. METHODS: Mice were subjected to a high-fat diet (HFD) to establish NAFLD models. Liver tissue was examined for lipid metabolism, fibrosis, and inflammation. Mouse 3T3-L1 adipocytes were exposed to palmitic acid (PA) to mimic a high-fat environment...
March 2, 2024: Tissue & Cell
https://read.qxmd.com/read/38471114/neutrophil-based-bionic-delivery-system-breaks-through-the-capillary-barrier-of-liver-sinusoidal-endothelial-cells-and-inhibits-the-activation-of-hepatic-stellate-cells
#36
JOURNAL ARTICLE
Dan Sun, Xiao Du, Xinyu Cao, Bingyu Wu, Shanshan Li, Yongmei Zhao, Tianqing Liu, Lixing Xu, Haiqin Huang
The capillarization of hepatic sinusoids resulting from the activation of hepatic stellate cells poses a significant challenge, impeding the effective delivery of therapeutic agents to the Disse space for liver fibrosis treatment. Therefore, overcoming these barriers and achieving efficient drug delivery to activated hepatic stellate cells (aHSCs) are pressing challenge. In this study, we developed a synergistic sequential drug delivery approach utilizing neutrophil membrane hybrid liposome@atorvastatin/amlisentan (NCM@AtAm) and vitamin A-neutrophil membrane hybrid liposome @albumin (VNCM@Bai) nanoparticles (NPs) to breach the capillary barrier for targeted HSC cell delivery...
March 12, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38470497/infiltrative-vessel-co-optive-growth-pattern-induced-by-iqgap3-overexpression-promotes-microvascular-invasion-in-hepatocellular-carcinoma
#37
JOURNAL ARTICLE
Miaoling Tang, Shuxia Zhang, Meisongzhu Yang, Rongni Feng, Jinbin Lin, Xiaohong Chen, Yingru Xu, Ruyuan Yu, Xinyi Liao, Ziwen Li, Xincheng Li, Man Li, Qiliang Zhang, Suwen Chen, Wanying Qian, Yuanji Liu, Libing Song, Jun Li
PURPOSE: Microvascular invasion (MVI) is a major unfavorable prognostic factor for intrahepatic metastasis and postoperative recurrence of hepatocellular carcinoma (HCC). However, the intervention and preoperative prediction for MVI remain clinical challenges due to the absent precise mechanism and molecular marker(s). Herein, we aimed to investigate the mechanisms underlying vascular invasion that can be applied to clinical intervention for MVI in HCC. EXPERIMENTAL DESIGN: The histopathological characteristics of clinical MVI+/HCC specimens were analyzed using multiplex immunofluorescence staining...
March 12, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38469403/quantitative-proteomics-reveals-the-protective-effects-of-yinchenzhufu-decoction-against-cholestatic-liver-fibrosis-in-mice-by-inhibiting-the-pdgfr%C3%AE-pi3k-akt-pathway
#38
JOURNAL ARTICLE
Qian Meng, Hongwen Zhu, Yuanyuan Li, Xiaotian Peng, Tianming Wang, Hui Huang, Hu Zhou, Yuejia Liu, Sujie Ru, Jiasheng Wu, Yueming Ma
Introduction: Yinchenzhufu decoction (YCZFD) is a traditional Chinese medicine formula with hepatoprotective effects. In this study, the protective effects of YCZFD against cholestatic liver fibrosis (CLF) and its underlying mechanisms were evaluated. Methods: A 3, 5-diethoxycarbonyl-1, 4-dihydro-collidine (DDC)-induced cholestatic mouse model was used to investigate the amelioration of YCZFD on CLF. Data-independent acquisition-based mass spectrometry was performed to investigate proteomic changes in the livers of mice in three groups: control, model, and model treated with high-dose YCZFD...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38468370/curcumin-modulates-nox-gene-expression-and-ros-production-via-p-smad3c-in-tgf-%C3%AE-activated-hepatic-stellate-cells
#39
JOURNAL ARTICLE
Samaneh Salehipour Bavarsad, Shahla Asadizade, Mahdi Hatami, Mojtaba Rashidi, Benyamin Kabizade, Elham Elham
BACKGROUND: Liver fibrosis, linked to HSCs, occurs when a healthy liver sustains damage, impairing its function. NOXs (1, 2, and 4) generate ROS during injuries, leading to fibrosis. The present study aimed to investigate the effects of curcumin in reducing NOX and ROS levels. This compound was also studied for its effects on NOXs, ROS production, and Smad3 phosphorylation in TGF-β-activated human HSCs. METHODS: MTT assay was employed to investigate the cytotoxic effects of curcumin on HSCs...
October 28, 2023: Iranian Biomedical Journal
https://read.qxmd.com/read/38465509/high-level-of-c3-is-associated-with-th2-immune-response-and-liver-fibrosis-in-patients-with-schistosomiasis
#40
JOURNAL ARTICLE
Xianmo Wang, Quan Gong, Hao Nie, Jiancheng Tu, Wen Fan, Xiaoping Tan
Long-term infection of schistosomiasis will seriously affect the liver health of patients. The serum of 334 chronic Schistosoma japonicum patients and 149 healthy volunteers was collected. Compared with heathy people, the level of C4 (complement 4) was increased, and the level of C3 (complement 3) was in an obvious skewed distribution. ELISA was performed to detect the serum cytokines, the results showed that the levels of IFN-γ (interferon-γ), IL (interleukin)-2 and TNF-α (tumour necrosis factor-α) were reduced, while the levels of Th2 cytokines (IL-4, IL-6 and IL-10) were increased...
March 2024: Parasite Immunology
keyword
keyword
38577
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.