Yake Wang, Xiaolong Li, Xiaowen Guan, Zhe Song, Huanfei Liu, Zhenzhen Guan, Jianwei Wang, Lina Zhu, Di Zhang, Liang Zhao, Peitong Xie, Xiaoyi Wei, Ning Shang, Ying Liu, Zhongzhen Jin, Zhili Ji, Guifu Dai
Liver fibrosis poses a significant global health risk due to its association with hepatocellular carcinoma (HCC) and the lack of effective treatments. Thus, the need to discover additional novel therapeutic targets to attenuate liver diseases is urgent. Leucine-rich repeat containing 1 (LRRC1) reportedly promotes HCC development. Previously, we found that LRRC1 was significantly upregulated in rat fibrotic liver according to the transcriptome sequencing data. Herein, in the current work, we aimed to explore the role of LRRC1 in liver fibrosis and the underlying mechanisms involved...
February 27, 2024: International Journal of Molecular Sciences