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Hepatic stellate cell

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https://www.readbyqxmd.com/read/29333048/astaxanthin-ameliorates-hepatic-damage-and-oxidative-stress-in-carbon-tetrachloride-administered-rats
#1
Md Ariful Islam, Md Abdullah Al Mamun, Md Faruk, Md Tauhid Ul Islam, Md Mizanur Rahman, Mohammad Nazmul Alam, A F M Towheedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Background: Astaxanthin is of carotenoids group which possess strong antioxidant properties. The present study was conducted to evaluate the hepatoprotective effects of astaxanthin in carbon tetrachloride (CCl4)-treated rats. Materials and Methods: Female Long-Evans rats were administered with CCl4 orally (1 ml/kg) twice a week for 2 weeks and were treated with astaxanthin (10 mg/kg) every day for 2 weeks. Blood plasma samples were isolated from each group and were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase activities...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29330728/analysis-of-plasma-tenascin-c-in-post-hcv-cirrhosis-a-prospective-study
#2
Jennifer H Benbow, April D Elam, Krista L Bossi, Danae L Massengill, Elizabeth Brandon-Warner, William E Anderson, Catherine R Culberson, Mark W Russo, Andrew S deLemos, Laura W Schrum
BACKGROUND AND AIM: Hepatitis C virus (HCV)-related cirrhosis, one of the most common etiologies of liver cirrhosis in the Western world, is a risk factor for hepatocellular carcinoma. To confirm and improve current effectiveness of screening and prognosis of patients with established cirrhosis, a credible, simple plasma biomarker is needed. Hepatic stellate cell activation, a pivotal event in cirrhosis development, results in increased secretion of extracellular matrix proteins, including tenascin-C (TnC)...
January 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29329619/hepatic-fibropoiesis-in-dogs-naturally-infected-with-leishmania-leishmania-infantum-treated-with-liposome-encapsulated-meglumine-antimoniate-and-allopurinol
#3
R S Castro, I F G de Amorim, R A Pereira, S M Silva, L J Pinheiro, A J W Pinto, E G Azevedo, C Demicheli, M M V Caliari, D M Mosser, M S M Michalick, Frédéric J G Frezard, Wagner L Tafuri
Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum treated with liposome-encapsulated meglumine antimoniate and allopurinol separately and in combination. Six treatment groups were defined: meglumine antimoniate encapsulated in nanometric liposomes (LMA), allopurinol (ALLOP); liposome-encapsulated meglumine antomoniate combined with allopurinol (LMA+ALLOP); empty liposomes (LEMP); empty liposomes combined with allopurinol (LEMP+ALLOP) and saline...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29328499/mait-cells-are-chronically-activated-in-patients-with-autoimmune-liver-disease-and-promote-pro-fibrogenic-hepatic-stellate-cell-activation
#4
Katrin Böttcher, Krista Rombouts, Francesca Saffioti, Davide Roccarina, Matteo Rosselli, Andrew Hall, TuVinh Luong, Emmanuel A Tsochatzis, Douglas Thorburn, Massimo Pinzani
Autoimmune liver diseases (AILD) are chronic liver pathologies characterised by fibrosis and cirrhosis due to immune-mediated liver damage. In this study, we addressed the question whether mucosal-associated invariant T (MAIT) cells, innate-like T cells, are functionally altered in patients with AILD and whether MAIT cells can promote liver fibrosis through activation of hepatic stellate cells. We analysed the phenotype and function of MAIT cells from AILD patients and healthy controls by multi-colour flow cytometry and investigated the interaction between human MAIT cells and primary human hepatic stellate cells (hHSCs)...
January 12, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29327938/glaucocalyxin-a-attenuates-the-activation-of-hepatic-stellate-cells-through-the-tgf-%C3%AE-1-smad-signaling-pathway
#5
Zhichao Dong, Qi Gao, Hao Guo
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx. A large number of studies have shown that GLA possesses important pharmacological activities, such as anti-inflammatory, antitumor, antifibrosis, and antiplatelet activities. However, the role of GLA in the pathogenesis of liver fibrosis remains undefined. Therefore, the aim of this study was to investigate the effects of GLA on hepatic stellate cells (HSCs) activation/proliferation and migration in vitro and its possible mechanism in liver fibrosis...
January 12, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29325017/cell-type-resolved-alternative-splicing-patterns-in-mouse-liver
#6
Peng Wu, Donghu Zhou, Weiran Lin, Yanyan Li, Handong Wei, Xiaohong Qian, Ying Jiang, Fuchu He
Alternative splicing (AS) is an important post-transcriptional regulatory mechanism to generate transcription diversity. However, the functional roles of AS in multiple cell types from one organ have not been reported. Here, we provide the most comprehensive profile for cell-type-resolved AS patterns in mouse liver. A total of 13,637 AS events are detected, representing 81.5% of all known AS events in the database. About 46.2% of multi-exon genes undergo AS from the four cell types of mouse liver: hepatocyte, liver sinusoidal endothelial cell, Kupffer cell and hepatic stellate cell, which regulates cell-specific functions and maintains cell characteristics...
January 8, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29324755/hiv-1-co-receptor-tropism-and-liver-fibrosis-in-hiv-infected-patients
#7
Annalisa Saracino, Alessandro Cozzi-Lepri, Milensu Shanyinde, Francesca Ceccherini Silberstein, Silvia Nozza, Antonio Di Biagio, Giovanni Cassola, Giuseppe Bruno, Maria Capobianchi, Massimo Puoti, Laura Monno, Antonella d'Arminio Monforte
BACKGROUND: In vitro, gp120 of both X4 and R5 HIV-1 strains activates human hepatic stellate cells, but if it can promote liver fibrosis in vivo is unknown. We aimed to evaluate if patients carrying X4 or R5 strains have a different liver fibrosis (LF) progression over time. METHODS: A total of 1,137 HIV-infected patients in ICONA cohort (21% females, 7% HCV co-infected) with an available determination of HIV-1 co-receptor tropism (CRT), a Fibrosis-4 Index for Liver Fibrosis (FIB-4) <3...
2018: PloS One
https://www.readbyqxmd.com/read/29322133/anti-fibrotic-activity-of-polyphenol-enriched-sugarcane-extract-in-rats-via-inhibition-of-p38-and-jnk-phosphorylation
#8
Liwen Wang, Min-Hsiung Pan, Chih-Yu Lo, Hui Zhao, Shiming Li, Chi-Tang Ho, Guliang Yang
Sugarcane (Saccharum officinarum L.), which is one of the most important sources of sugar, is also rich in polyphenolic compounds. In this study, polyphenols from sugarcane were extracted, and the dominant component was characterized quantitatively via HPLC to be (-)-epicatechin. Fibrosis occurs in many organs and is associated with severe tissue damage. Liver fibrosis is the excessive accumulation of extracellular matrix proteins and advanced liver fibrosis, resulting in cirrhosis, liver failure and portal hypertension...
January 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29318378/mac-2-binding-protein-glycan-isomer-m2bpgi-is-a-new-serum-biomarker-for-assessing-liver-fibrosis-more-than-a-biomarker-of-liver-fibrosis
#9
REVIEW
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu, Masashi Mizokami
Assessing liver fibrosis is important for predicting the efficacy of antiviral therapy and patient prognosis. Liver biopsy is the gold standard for diagnosing liver fibrosis, despite its invasiveness and problematic diagnostic accuracy. Although noninvasive techniques to assess liver fibrosis are becoming important, reliable serum surrogate markers are not available. A glycoproteomics study aimed at identifying such markers discovered Mac 2-Binding Protein Gylcan Isomer (M2BPGi), which is a reliable marker for assessing liver fibrosis in patients with viral hepatitis and other fibrotic liver diseases such as primary biliary cholangitis, biliary atresia, autoimmune hepatitis, and nonalcoholic fatty liver disease...
January 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29317465/perilipin-5-and-liver-fatty-acid-binding-protein-function-to-restore-quiescence-in-mouse-hepatic-stellate-cells
#10
Jianguo Lin, Shizhong Zheng, Alan D Attie, Mark P Keller, David A Bernlohr, William S Blaner, Elizabeth P Newberry, Nicholas O Davidson, Anping Chen
Hepatic stellate cell (HSC) activation occurs along with decreased Perilipin5 (Plin5) and liver fatty acid-binding protein (L-Fabp) expression and coincident lipid droplet (LD) depletion. Conversely, the activated phenotype is reversible in wild type (wt) HSCs upon forced expression of Plin5. Here we asked if L-Fabp expression is required for Plin5-mediated rescue of the quiescent phenotype. Lentiviral Plin5 transduction of passaged L-Fabp-/- HSCs failed to reverse activation markers or to restore lipogenic gene expression and LD formation...
January 9, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29315209/the-bioactive-extract-of-pinnigorgia-sp-induces-apoptosis-of-hepatic-stellate-cells-via-ros-erk-jnk-caspase-3-signaling
#11
Liang-Mou Kuo, Po-Jen Chen, Ping-Jyun Sung, Yu-Chia Chang, Chun-Ting Ho, Yi-Hsiu Wu, Tsong-Long Hwang
The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the viability of HSC-T6 cells and increased their subG1 population, DNA fragmentation, caspase-3 activation, and reactive oxygen species (ROS) production in a concentration-dependent manner. The Pin-induced ROS generation and apoptotic effects were significantly reversed by a thiol antioxidant, N-acetylcysteine (NAC)...
January 9, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29312560/ultrasound-molecular-imaging-with-crgd-plga-pfob-nanoparticles-for-liver-fibrosis-staging-in-a-rat-model
#12
Jiqing Xuan, Yuli Chen, Leilei Zhu, Yuan Guo, Liming Deng, Yuanyi Zheng, Zhaoxia Wang, Zhigang Wang, Meng Ao
Hepatic fibrosis is the only chronic liver disease process that can be reversed. Developing non-invasive and effective methods to quantitatively assess the degree of liver fibrosis is of great clinical significance and remains a major challenge. The key factors in hepatic fibrosis pathogenesis are the activation and proliferation of hepatic stellate cells that subsequently express integrin αvβ3. An ultrasound (US) agent combined with a targeting peptide may be used for the early and non-invasive diagnosis of hepatic fibrosis...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29312539/regulatory-t-cells-with-a-defect-in-inhibition-on-co-stimulation-deteriorated-primary-biliary-cholangitis
#13
Jianing Chen, Xianliang Hou, Hongyu Jia, Guangying Cui, Zhongwen Wu, Lin Wang, Chong Lu, Wei Wu, Yingfeng Wei, Toshimitsu Uede, Lanjuan Li, Zhexiong Lian, Hongyan Diao
Regulatory T cells (Tregs) play an indispensable role in the progression of primary biliary cholangitis (PBC). Although Tregs could normalize costimulation in in vivo and in vitro models, it is obscure whether and how Tregs mediate these effects in PBC. Herein we focused on the quantitative and functional characteristics of Tregs in PBC. The number and proportion of Tregs, and the production of interleukin (IL)-10 were all significantly less in the PBC patients than in the healthy controls (HCs). In addition, compared to the HCs, the costimulatory CD86 of the circulation and liver were significantly higher in the patients with PBC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29305935/hedgehog-yap-signaling-pathway-regulates-glutaminolysis-to-control-hepatic-stellate-cell-activation
#14
Kuo Du, Jeongeun Hyun, Richard T Premont, Steve S Choi, Gregory A Michelotti, Marzena Swiderska-Syn, George D Dalton, Eric Thelen, Bahar Salimian Rizi, Youngmi Jung, Anna Mae Diehl
BACKGROUND & AIMS: Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activating Yes-associated protein 1 (YAP1 or YAP) and inducing aerobic glycolysis. However, increased aerobic glycolysis alone cannot meet the high metabolic demands of myofibroblastic HSCs. Determining the metabolic processes of these cells could lead to strategies to prevent progressive liver fibrosis, so we investigated whether glutaminolysis (conversion of glutamine to alpha-ketoglutarate) sustains energy metabolism and permits anabolism when Q-HSCs become myofibroblastic, and whether this is controlled by hedgehog signaling to YAP...
January 3, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29305319/role-of-a-kinase-anchoring-protein-phosphorylation-in-alcohol-induced-liver-injury-and-hepatic-stellate-cell-activation
#15
Komal Ramani, Maria Lauda Tomasi, Joshua Berlind, Nirmala Mavila, Zhaoli Sun
Alcoholic liver injury is associated with hepatic stellate cell (HSC) activation. A-kinase anchoring protein 12 (AKAP12) scaffolds protein kinase C (PKC-α) and cyclin-D1, which is regulated by its phosphorylation, and spatiotemporally controls cell proliferation, invasiveness, and chemotaxis. HSC activation induces AKAP12 expression but the role of AKAP12's scaffolding activity in liver function is unknown. Since AKAP12 phosphorylation is enhanced in ethanol-treated HSCs, we examined AKAP12's scaffolding functions in alcohol-mediated HSC activation and liver injury...
January 2, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29305174/inhibition-of-autophagy-reverses-alcohol-induced-hepatic-stellate-cells-activation-through-activation-of-nrf2-keap1-are-signaling-pathway
#16
Zheng-Yuan Xie, Zhi-Hua Xiao, Fen-Fen Wang
BACKGROUND: Numerous documents have indicated a critical role of autophagy in alcoholic liver fibrosis (ALF), but few papers have reported its function in hepatic stellate cells (HSCs) activation. The current study aimed to investigate the regulation effect of autophagy in HSCs activation, in further to explore the underlying mechanism involved. METHODS: HSC-T6 cells were treated with ethanol, 3-MA (autophagy inhibitor) or rapamycin (autophagy inducer), and cells were also transfected with si-Nrf2 or si-Keap1...
January 2, 2018: Biochimie
https://www.readbyqxmd.com/read/29299986/significance-of-hepatoprotective-liver-specific-targeted-drug-delivery-a-review-on-novel-herbal-and-formulation-approaches-in-management-of-hepatotoxicity
#17
Surbhi Rohilla, D C Bhatt
BACKGROUND: The liver is the largest and vital organ present in all vertebrates. It performs various major functions such as detoxification, metabolism, protein synthesis, excretion and so on. Liver cells are divided into parenchymal cells and non-parenchymal cells. Hepatocytes, Kupffer cells, hepatic stellate cells and sinusoidal endothelial cells, etc are found in liver having different receptors present on their surface which can be used for liver targeting by binding to different ligands...
January 3, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29299120/hif-1%C3%AE-contributes-to-hypoxia-adaptation-of-the-naked-mole-rat
#18
Bang Xiao, Shiyong Wang, Guoshi Yang, Xiaoxi Sun, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Wei Sun, Guanghan Kan, Shufang Cui
Background/Aims: Naked mole rats (NMRs) spend their lives in burrow systems containing very low levels of oxygen, indicating long-term hypoxic exposure, and suggesting that pathological changes caused by hypoxia are attenuated or absent in this hypoxia-tolerant species. The mechanisms underlying NMRs hypoxia tolerance remain poorly understood. In this study, we explored whether hypoxia inducible factor 1α (HIF-1α), and vascular endothelial growth factor A (VEGFA) play a role in NMRs adaption to hypoxia...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29296191/3-methyladenine-ameliorates-liver-fibrosis-through-autophagy-regulated-by-the-nf-%C3%AE%C2%BAb-signaling-pathways-on-hepatic-stellate-cell
#19
Bingying Wang, Huan Yang, Yinyin Fan, Yong Yang, Wei Cao, Yanwei Jia, Ying Cao, Kangyun Sun, Zhi Pang, Hong Du
3-Methyladenine (3-MA) is a selective type III phosphatidylinositol 3-kinase (PI3K) inhibitor and also blocks autophagosome formation. However, the effect of 3-MA in liver fibrosis has yet to be determined. Recent studies have demonstrated that autophagy is closely related to activation of hepatic stellate cells (HSC), a process critical in the pathogenesis of liver fibrosis. And the transcription factor nuclear factor-kappaB (NF-κB) is proved to play an important role in autophagy-induced signaling pathways...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290652/in-vivo-hepatic-differentiation-potential-of-human-umbilical-cord-derived-mesenchymal-stem-cells-therapeutic-effect-on-liver-fibrosis-cirrhosis
#20
Guo-Zun Zhang, Hui-Cong Sun, Li-Bo Zheng, Jin-Bo Guo, Xiao-Lan Zhang
AIM: To investigate the hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and to evaluate their therapeutic effect on liver fibrosis/cirrhosis. METHODS: A CCl4-induced liver fibrotic/cirrhotic rat model was used to assess the effect of hUC-MSCs. Histopathology was assessed by hematoxylin and eosin (H&E), Masson trichrome and Sirius red staining. The liver biochemical profile was measured using a Beckman Coulter analyzer...
December 14, 2017: World Journal of Gastroenterology: WJG
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