Louise Roer, Søren Overballe-Petersen, Frank Hansen, Kristian Schønning, Mikala Wang, Bent L Røder, Dennis S Hansen, Ulrik S Justesen, Leif P Andersen, David Fulgsang-Damgaard, Katie L Hopkins, Neil Woodford, Linda Falgenhauer, Trinad Chakraborty, Ørjan Samuelsen, Karin Sjöström, Thor B Johannesen, Kim Ng, Jens Nielsen, Steen Ethelberg, Marc Stegger, Anette M Hammerum, Henrik Hasman
Escherichia coli sequence type 410 (ST410) has been reported worldwide as an extraintestinal pathogen associated with resistance to fluoroquinolones, third-generation cephalosporins, and carbapenems. In the present study, we investigated national epidemiology of ST410 E. coli isolates from Danish patients. Furthermore, E. coli ST410 was investigated in a global context to provide further insight into the acquisition of the carbapenemase genes bla OXA-181 and bla NDM-5 of this successful lineage. From 127 whole-genome-sequenced isolates, we reconstructed an evolutionary framework of E...
July 18, 2018: MSphere