Carlo Briguori, Cristina Quintavalle, Enrica Mariano, Alessandro D'Agostino, Mario Scarpelli, Amelia Focaccio, Giuseppe Biondi Zoccai, Salvatore Evola, Giovanni Esposito, Giuseppe Massimo Sangiorgi, Gerolama Condorelli
BACKGROUND: Acute kidney injury (AKI) is common in patients with acute coronary syndromes (ACS) treated by percutaneous coronary intervention. OBJECTIVES: Contrast media (CM) volume minimization has been advocated for prevention of AKI. The DyeVert CM diversion system (Osprey Medical, Inc) is designed to reduce CM volume during coronary procedures. METHODS: In this randomized, single-blind, investigator-driven clinical trial conducted in 4 Italian centers from February 4, 2020 to September 13, 2022, 550 participants with ACS were randomly assigned in a 1:1 ratio to the following: 1) the contrast volume reduction (CVR) group (n = 276), in which CM injection was handled by the CM diversion system; and 2) the control group (n = 274), in which a conventional manual or automatic injection syringe was used...
March 19, 2024: Journal of the American College of Cardiology