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https://www.readbyqxmd.com/read/29150947/levels-of-serum-retinol-binding-protein-4-before-and-after-non-surgical-periodontal-treatment-in-lean-and-obese-subjects-an-interventional-study
#1
Mayte Martínez-Herrera, Francisco Javier Silvestre, Javier Silvestre-Rangil, Sandra López-Domènech, Celia Bañuls, Milagros Rocha
AIM: We aimed to evaluate serum RBP4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis (CP) in order to determine its possible association with periodontitis. MATERIALS AND METHODS: This is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with CP were evaluated before and after three months of non-surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of TNFα, IL-6, hsCRP and RBP4 were assessed...
November 18, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29146378/association-of-p-wave-duration-index-with-atrial-fibrillation-recurrence-after-cryoballoon-catheter-ablation
#2
Onur Kaypakli, Hasan Koca, Durmuş Yıldıray Şahin, Sefa Okar, Fadime Karataş, Mevlüt Koç
AIM: We aimed to investigate the relationship between the recurrence of AF and P wave duration index (PWDI) in patients with nonvalvular PAF. METHODS: We included 114 patients who underwent cryoballoon catheter ablation with the diagnosis of paroxysmal atrial fibrillation (PAF) (55 male, 59 female; mean age 55.5±10,9years). PWDI was calculated by dividing the Pwd by the PR interval in DII lead of 12‑lead ECG. Patients had regular follow-up visits with 12-lead ECG, medical history and clinical evaluation...
October 9, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29146124/relationship-of-c-reactive-protein-reduction-to-cardiovascular-event-reduction-following-treatment-with-canakinumab-a-secondary-analysis-from-the-cantos-randomised-controlled-trial
#3
Paul M Ridker, Jean G MacFadyen, Brendan M Everett, Peter Libby, Tom Thuren, Robert J Glynn
BACKGROUND: Canakinumab, a monoclonal antibody targeting interleukin-1β, reduces inflammation and cardiovascular event rates with no effect on lipid concentrations. However, it is uncertain which patient groups benefit the most from treatment and whether reductions in the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) correlate with clinical benefits for individual patients. METHODS: The Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS) used computer-generated codes to randomly allocate 10 061 men and women with a history of myocardial infarction to placebo or one of three doses of canakinumab (50 mg, 150 mg, or 300 mg) given subcutaneously once every 3 months...
November 13, 2017: Lancet
https://www.readbyqxmd.com/read/29143290/increased-free-testosterone-levels-in-men-with-uncontrolled-type-2-diabetes-five-years-after-randomization-to-bariatric-surgery
#4
Nathan H Pham, James Bena, Deepak L Bhatt, Laurence Kennedy, Philip R Schauer, Sangeeta R Kashyap
Hypogonadism frequently occurs in male patients with type 2 diabetes (T2DM) and is linked to insulin resistance and inflammation. Testosterone levels rise acutely in obese patients following bariatric surgery, though long-term changes have not been investigated in a randomized controlled trial. This study evaluated obese men with T2DM randomized to either bariatric surgery or medical therapy. Testosterone, gonadotropins, body composition, insulin sensitivity, and inflammatory markers were evaluated in 32 patients at baseline and at 5 years...
November 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29141371/-effect-of-recombinant-human-growth-hormone-therapy-on-metabolic-parameters-in-patients-with-craniopharyngioma
#5
J F Mao, X Wang, S Y Xiong, J J Zheng, B Q Yu, M Nie, X Y Wu, S T Qi
Objective: To investigate the effects of recombinant human growth hormone (rhGH) on metabolic parameters in patients with craniopharyngioma surgeries. Methods: Totallys 30 patients with craniopharyngioma were included in this retrospective study. They were divided into growth hormone (GH) group and control group according to whether they received rhGH therapy or not. The following parameters, including body mass index (BMI), weight, waist circumstance, transaminase, fasting blood glucose, lipid profile and high-sensitivity C-reactive protein (hsCRP) were compared after rhGH therapy for 4-6 months...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29131287/the-relationship-between-ischemia-modified-albumin-and-good-coronary-collateral-circulation
#6
Murat Gök, Harun Kundi, Emrullah Kızıltunç, Canan Topcuoglu, Ender Örnek
BACKGROUND: It is important to determine the grade of the coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD). AIM: In this study, we aimed to investigate the relationship between the ischemia modified albumin (IMA) level and good CCC. METHODS: A total of 95 patients with coronary angiography and at least one epicardial coronary artery obstruction were included in the study. The Rentrop classification was used with CCC grading, where 0 and 1 were defined as poor collateral, and 2 and 3 were defined as good collateral...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29130747/influence-of-storage-and-inter-and-intra-assay-variability-on-the-measurement-of-inflammatory-biomarkers-in-population-based-biobanking
#7
Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Melanie M van der Klauw, Jan Koerts, Gabriele Anton, Annette Peters, Gerlinde Trischler, Kirsti Kvaløy, Marit Naess, Vibeke Videm, Kristian Hveem, Melanie Waldenberger, Wolfgang Koenig, Bruce H R Wolffenbuttel
BACKGROUND: In the present study, we examined the effect of sample storage on the reproducibility of several inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), high-sensitivity interleukin-6 (hsIL6), and high-sensitivity tumor necrosis factor alpha (hsTNFα). In addition, we assessed inter- and intra-assay variability between collaborating biobanks. METHODS: In total, 240 fasting plasma samples were obtained from the LifeLines biobank...
November 13, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29128140/comparative-assessment-of-serum-adipokines-zinc-%C3%AE-2-glycoprotein-and-adipose-triglyceride-lipase-and-cardiovascular-risk-factors-between-normal-weight-and-obese-patients-with-hemodialysis
#8
Mohammad Javad Hosseinzadeh-Attar, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges Sadat Zahed, Elham Alipoor
BACKGROUND: Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and glucose metabolism. The aim of this study was to investigate serum concentrations of ZAG and ATGL, and the relationship of these adipokines with cardiovascular risk factors in normal weight (NW) and obese (OB) patients undergoing hemodialysis...
November 8, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29123173/effect-of-vitamin-d-supplementation-on-inflammation-and-nuclear-factor-kappa-b-activity-in-overweight-obese-adults-a-randomized-placebo-controlled-trial
#9
Aya Mousa, Negar Naderpoor, Josphin Johnson, Karly Sourris, Maximilian P J de Courten, Kirsty Wilson, Robert Scragg, Magdalena Plebanski, Barbora de Courten
In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFκB) activity. Yet, no trials have examined the effects of vitamin D supplementation on NFκB activity in-vivo in humans. We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NFκB activity in peripheral blood mononuclear cells (PBMCs). Sixty-five overweight/obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH)D] ≤ 50 nmol/L) adults were randomized to a single 100,000 IU bolus followed by 4,000 IU daily cholecalciferol or matching placebo for 16 weeks...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117621/gender-differences-in-cardiometabolic-risk-factors-in-metabolically-healthy-normal-weight-adults-with-central-obesity
#10
Katarína Šebeková, Melinda Csongová, Radana Gurecká, Zora Krivošíková, Jozef Šebek
We investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29108337/elevated-hemoglobin-glycation-index-identify-non-diabetic-individuals-at-increased-risk-of-kidney-dysfunction
#11
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether higher HGI levels are associated with impaired kidney function also among nondiabetic individuals. The study group comprised 1505 White nondiabetic individuals stratified in quartiles according to HGI levels...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105364/association-between-killer-cell-immunoglobulin-like-receptor-2ds5-gene-with-essential-hypertension-in-the-chinese-han-patients
#12
A L Wang, B Jiang, X Y Qian, Q Zhang, H Peng, Y H Zhang
Hypertension has been suggested to be mediated by immunity and inflammation. As immune system genes, killer cell immunoglobulin-like receptors (KIRs) genes play an important role in the pathogenesis of autoimmune diseases. We conducted a community population-based case-control study to analyse associations between KIR genes and hypertension. KIR genes were genotyped using sequence-specific primer polymerase chain reaction in 380 unrelated essential hypertensives and 527 normotensives. The frequencies of KIR2DS5 gene were significantly decreased in participants with high high-sensitivity C-reactive protein (hsCRP) compared with participants with low hsCRP (17...
November 3, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29104456/sports-and-hdl-quality-reflected-by-serum-amyloid-a-and-surfactant-protein-b
#13
Michael Sponder, Chantal Kopecky, Ioana-Alexandra Campean, Michael Emich, Monika Fritzer-Szekeres, Brigitte Litschauer, Senta Graf, Marcus D Säemann, Jeanette Strametz-Juranek
Background: The aim of this prospective study was to investigate the influence of long-term physical activity on HDL quality, reflected by serum amyloid A (SAA) and surfactant protein B (SPB). Methods and results: 109 healthy subjects were recruited, 98 completed the study. Participants perform within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. SAA and SPB were measured at baseline and after 4 and 8 months by ELISA...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29102596/assessment-of-novel-cardiovascular-biomarkers-in-women-with-a-history-of-recurrent-miscarriage
#14
M M Wagner, J W Jukema, W Hermes, S le Cessie, C J M de Groot, J A Bakker, J M M van Lith, K W M Bloemenkamp
OBJECTIVES: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. STUDY DESIGN: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-up study (between 2012 and 2014)...
October 28, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29097485/increased-inflammatory-response-in-association-with-the-initiation-of-hemodialysis-compared-with-peritoneal-dialysis-in-a-prospective-study-of-end-stage-kidney-disease-patients
#15
Yong Kenneth, Gursharan Dogra, Neil C Boudville, Wai H Lim
BACKGROUND: Large epidemiological studies have demonstrated an early survival advantage with the initiation of peritoneal dialysis (PD) compared to haemodialysis (HD). Chronic inflammation may contribute to atherosclerosis and cardiovascular (CVD) mortality in end-stage kidney disease (ESKD). We hypothesize that the initiation of HD in ESKD patients is associated with a greater inflammatory response compared with PD. AIMS: To examine the effects of initiating HD and PD upon inflammation and CVD risk markers in ESKD patients...
November 2, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29096833/specific-lp-a-apheresis-a-tool-to-prove-lipoprotein-a-atherogenicity
#16
S N Pokrovsky, O I Afanasieva, M S Safarova, T V Balakhonova, Yu G Matchin, I Y U Adamova, G A Konovalov, M V Ezhov
BACKGROUND: An elevated lipoprotein(a) (Lp(a)) level is observed in more than 30% of patients with stable ischemic heart disease (SIHD). We conducted an investigation of the effects of specific Lp(a) apheresis on the progression of atherosclerosis in SIHD patients with Lp(a) levels greater than 50 mg/dL. METHODS: We prospectively enrolled 15 patients diagnosed with SIHD based on symptom-driven coronary angiography findings, with Lp(a) ≥50 mg/dL and a low density lipoprotein cholesterol (LDL-C) ≤2...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29089280/the-associations-of-endotoxemia-with-systemic-inflammation-endothelial-activation-and-cardiovascular-outcome-in-kidney-transplantation
#17
Winnie Chan, Jos A Bosch, Anna C Phillips, Shui Hao Chin, Adaikala Antonysunil, Nicholas Inston, Sue Moore, Okdeep Kaur, Philip G McTernan, Richard Borrows
OBJECTIVE: Cardiovascular disease is the leading cause of death in kidney transplant recipients (KTRs), yet incompletely accountable by traditional risk factors. Inflammation is an unconventional cardiovascular risk factor, with gut-derived endotoxemia potentially driving inflammation and endothelial disease. Comparable data are lacking in kidney transplantation. This study investigated the associations of endotoxemia with inflammation, endothelial activation, and 5-year cardiovascular events in KTRs...
October 28, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29081162/-relationship-between-inflammatory-markers-and-the-risk-of-colorectal-cancer-in-kailuan-male-cohort
#18
G Wang, W G Xu, F Li, K Su, N Li, Z Y Lü, X S Feng, L P Wei, H D Chen, Y H Chen, L W Guo, H Cui, W J Yang, Z F Li, J S Ren, S L Wu, J F Shi, M Dai, J He
Objective: To investigate whether elevated levels of high sensitivity C-Reactive Protein (hsCRP) and neutrophil (NE) at baseline are associated with an increased risk of colorectal cancer in Kailuan male cohort. Methods: Since May 2006, males from Kailuan cohort were included in this study. Information on demographics, medical history, anthropometry, hsCRP and NE were collectedat baseline for all subjects. Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HR) of association between baseline hsCRP and NE and colorectal cancer risk...
October 31, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29078256/predicting-persistent-impaired-glucose-tolerance-in-gdm-women-the-role-of-hscrp-and-adiponectin
#19
Celeste P Durnwald, Katheryne Downes, Rita Leite, Michal Elovitz, Samuel Parry
BACKGROUND: To evaluate whether maternal serum adiponectin and high-sensitivity C-reactive protein (hsCRP) levels at the time of gestational diabetes (GDM) diagnosis are associated with persistent glucose intolerance in GDM women at 6-12 weeks postpartum. METHODS: This is a secondary analysis of prospective randomized trial of GDM women enrolled in a behavior education program. Women with a GDM diagnosis ≥ 20 weeks were included. At the time of randomization, serum adiponectin and hsCRP levels were drawn...
October 27, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29075862/concomitant-external-pneumatic-compression-treatment-with-consecutive-days-of-high-intensity-interval-training-reduces-markers-of-proteolysis
#20
Cody T Haun, Michael D Roberts, Matthew A Romero, Shelby C Osburn, James C Healy, Angelique N Moore, Christopher B Mobley, Paul A Roberson, Wesley C Kephart, Petey W Mumford, Michael D Goodlett, David D Pascoe, Jeffrey S Martin
PURPOSE: To compare the effects of external pneumatic compression (EPC) and sham when used concurrently with high intensity interval training (HIIT) on performance-related outcomes and recovery-related molecular measures. METHODS: Eighteen recreationally endurance-trained male participants (age: 21.6 ± 2.4 years, BMI: 25.7 ± 0.5 kg/m(2), VO2peak: 51.3 ± 0.9 mL/kg/min) were randomized to balanced sham and EPC treatment groups. Three consecutive days of HIIT followed by EPC/sham treatment (Days 2-4) and 3 consecutive days of recovery (Days 5-7) with EPC/sham only on Days 5-6 were employed...
October 26, 2017: European Journal of Applied Physiology
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