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https://www.readbyqxmd.com/read/28429893/significant-associations-between-c-reactive-protein-levels-body-adiposity-distribution-and-peripheral-blood-cells-in-school-age-children
#1
Aralia Berenice Salgado-Bernabé, Luz Elena Ramos-Arellanol, Iris Paola Guzmán-Guzmán, José Francisco Muñoz-Valle, Natividad Castro-Alarcón, Amalia Vences-Velázquez, Lorenzo Salga-do-Goytia, Isela Parra-Rojas
Obesity is associated with a state of chronic low-grade inflammation. Ge- nerally, there are significant correlations between body mass index and increased C-reactive protein levels. We investigated the relationship of high sensitivity C-reactive protein (hsCRP) levels with body adiposity distribution and blood cell count in obese children. A cross-sec- tional study was performed in 225 Mexican children. In the study were included 106 obese and 119 normal-weight children, aged 6-13 years old. The body composition was evaluated by BMI, body circumferences and skinfold thickness...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28421814/elevated-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-endothelial-dysfunction-in-beh%C3%A3-et-disease
#2
Nusret Acikgoz, Ertuğrul Kurtoğlu, Julide Yagmur, Yelda Kapicioglu, Mehmet Cansel, Necip Ermis
Behçet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28421328/association-of-adiponectin-leptin-and-resistin-with-inflammatory-markers-and-obesity-in-dementia
#3
Małgorzata Bednarska-Makaruk, Ałła Graban, Anna Wiśniewska, Wanda Łojkowska, Anna Bochyńska, Magdalena Gugała-Iwaniuk, Ksenia Sławińska, Agnieszka Ługowska, Danuta Ryglewicz, Hanna Wehr
The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined...
April 18, 2017: Biogerontology
https://www.readbyqxmd.com/read/28415730/a-polymorphism-at-igf1-locus-is-associated-with-anemia
#4
Maria Adelaide Marini, Gaia Chiara Mannino, Teresa Vanessa Fiorentino, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti
In vitro and in vivo studies suggest that IGF-1 has a role in erythropoiesis. There is evidence that the rs35767 C/T polymorphism near IGF1 is associated with plasma IGF-1 levels. We investigated the effect of this polymorphism on hemoglobin (Hb) concentration and anemia. The study group comprised 3286 adult Whites. The rs35767 polymorphism was screened using a TaqMan allelic discrimination assay. The rs35767 polymorphism was not associated with age, gender, BMI, waist circumference, smoking, blood pressure, plasma glucose, HbA1c, type 2 diabetes, HOMA-IR, hsCRP, eGFR, and lipid profile...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412650/comparative-effects-of-cholesteryl-ester-transfer-protein-inhibition-statin-or-ezetimibe-on-lipid-factors-the-accentuate-trial
#5
Stephen J Nicholls, Kausik K Ray, Christie M Ballantyne, Lauren A Beacham, Debra L Miller, Giacomo Ruotolo, Steven E Nissen, Jeffrey S Riesmeyer
BACKGROUND AND AIMS: The optimal approaches to management of patients treated with moderate statin doses on lipid parameters are unknown. The ACCENTUATE study aimed to compare the effects of adding the cholesteryl ester transfer protein inhibitor (CETP) evacetrapib, ezetimibe or increasing statin dose in atorvastatin-treated high-vascular risk patients on lipid parameters. METHODS: 366 patients with atherosclerotic cardiovascular disease (ASCVD) and/or diabetes were treated with atorvastatin 40 mg/day for 28 days prior to randomization to atorvastatin 40 mg plus evacetrapib 130 mg, atorvastatin 80 mg, atorvastatin 40 mg plus ezetimibe 10 mg or atorvastatin 40 mg plus placebo, daily for 90 days at 64 centers in the United States...
April 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28410617/treatment-with-high-dose-n-3-pufas-has-no-effect-on-platelet-function-coagulation-metabolic-status-or-inflammation-in-patients-with-atherosclerosis-and-type-2-diabetes
#6
Malgorzata Poreba, Magdalena Mostowik, Aleksander Siniarski, Renata Golebiowska-Wiatrak, Krzysztof Piotr Malinowski, Maciej Haberka, Ewa Konduracka, Jadwiga Nessler, Anetta Undas, Grzegorz Gajos
BACKGROUND: Despite numerous studies on cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), there is limited evidence for n-3 PUFA-mediated effects, especially at its higher dose, on cardiovascular risk in patients with type 2 diabetes (DM2) and established atherosclerosis. PURPOSE: To investigate the effect of daily treatment with a higher dose (2 g) of n-3 PUFAs on platelet function, coagulation parameters, fibrin clot properties, markers of systemic inflammation and metabolic status, in patients with atherosclerotic vascular disease and DM2 who receive optimal medical therapy...
April 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28407807/subclinical-inflammation-associated-with-prolonged-timp-1-upregulation-and-arterial-stiffness-after-gestational-diabetes-mellitus-a-hospital-based-cohort-study
#7
Tiina Vilmi-Kerälä, Anneli Lauhio, Taina Tervahartiala, Outi Palomäki, Jukka Uotila, Timo Sorsa, Ari Palomäki
BACKGROUND: Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery...
April 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28406764/the-efficacy-of-tocilizumab-for-the-treatment-of-chinese-takayasu-s-arteritis
#8
Jiaxin Zhou, Zhe Chen, Jing Li, Yunjiao Yang, Jiuliang Zhao, Hu Chen, Min Liu, Fei Sun, Mengtao Li, Xinping Tian, Xiaofeng Zeng
OBJECTIVES: The aim of this study was to evaluate the efficacy and safety of tocilizumab (TCZ) in Chinese Takayasu's arteritis (TA) patients. METHODS: This was a single centre prospective study. Sixteen consecutive TA patients were included. Patients were treated with tocilizumab infusions with a dosage of 8mg/kg. Serum inflammation markers, including erythrocyte sedimentation rate (ESR) and hypersensitivity C reactive protein (hsCRP), were recorded at baseline and before each TCZ infusion...
April 10, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28406704/pro-inflammatory-gene-expression-in-adipose-tissue-of-patients-with-atherosclerosis
#9
S Čejková, I Králová Lesná, J Froněk, L Janoušek, A Králová, J Ždychová, R Poledne
Inflammatory changes, both in the arterial wall and adipose tissue, play a crucial role in the development of atherosclerosis. We measured the gene expression of tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and interleukin 6 (IL-6) in adipose tissue (AT) of living kidney donors (LKD) and patients with peripheral arterial disease (PAD). Quantitative polymerase chain reaction (qPCR) and flow cytometry analyses were performed in subcutaneous (SAT), visceral (VAT), and perivascular adipose tissue (PVAT)...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28403945/xanthine-oxidoreductase-activity-is-correlated-with-insulin-resistance-and-subclinical-inflammation-in-young-humans
#10
Kahori Watanabe Washio, Yoshiki Kusunoki, Takayo Murase, Takashi Nakamura, Keiko Osugi, Mana Ohigashi, Tadahiko Sukenaga, Fumihiro Ochi, Toshihiro Matsuo, Tomoyuki Katsuno, Yuji Moriwaki, Tetsuya Yamamoto, Mitsuyoshi Namba, Hidenori Koyama
BACKGROUND AND AIMS: The enzyme xanthine oxidoreductase (XOR) catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate. Besides the synthesis of UA, basic research has suggested that XOR is involved in the regulation of reactive oxygen species, adipogenesis, and peroxisome proliferator-activated receptor-γ (PPAR-γ). XOR activity has shown to be much lower in humans than in rodents, which makes its accurate measurement difficult...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28395210/low-serum-thyroid-stimulating-hormone-levels-are-associated-with-lipid-profile-in-depressive-patients-with-long-symptom-duration
#11
Rui Peng, Yan Li
OBJECTIVE: The current study was designed to investigate the association between serum thyroid hormones and thyroid-stimulating hormone (TSH) levels with lipid profile in depressive disorder. METHODS: A total of 370 depressive individuals aged 18 years and above were recruited in this cross-section study. All participants underwent a Structured Clinical Interview for DSM-IV (SCID) and recorded the duration of their symptoms. The serum levels of total cholesterol (TCH), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein A (Lp(a)), high-sensitivity C-reactive protein (hsCRP), free thyroxine (FT4), free triiodothyronine (FT3) and TSH levels were determined and the ratios of TCH/HDL-C were assessed...
March 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28394956/-being-physically-active-modifies-the-detrimental-effect-of-sedentary-behavior-on-obesity-and-cardiometabolic-markers-in-adults
#12
Carlos Salas, Carlos Cristi-Montero, Yu Fan, Eliana Durán, Ana María Labraña, María Adela Martínez, Ana María Leiva, Cristian Alvarez, Nicolás Aguilar-Farías, Rodrigo Ramírez-Campillo, Ximena Díaz Martínez, Ruth Sanzana-Inzunza, Carlos Celis-Morales
BACKGROUND: Sedentary behavior is a major risk factor for cardiovascular disease and mortality. AIM: To investigate whether the associations between sedentary behavior and cardiometabolic markers differs across physical activity levels. MATERIALS AND METHODS: Cross sectional study of 314 participants aged 18 to 65 years. Body mass index (BMI) and waist circumference were measured, and body fat was derived from the sum of four skinfolds. Physical activity was measured objectively using accelerometers (Actigraph GT1M, USA®)...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28394002/supplementation-with-omega-3-acids-after-myocardial-infarction-and-modification-of-inflammatory-markers-in-light-of-the-patients-diet-a-preliminary-study
#13
Magdalena Makarewicz-Wujec, Gabriela Parol, Andrzej Parzonko, Małgorzata Kozłowska-Wojciechowska
BACKGROUND: Neuroendocrine activation, activation of proinflammatory cytokines and platelets, and endothelial dysfunction play a significant role in development of heart failure. AIM: The aim of the work was to assess the effect of supplementation with EPA and DHA in adaily dose of 1g on selected inflammatory markers and platelet activation in patients with heart failure after recent myocardial infarction in light of their diet. M ETHODS: This preliminary study was arandomised, double-blind trial involving 30patients with post-infarction heart failure...
April 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28393707/relationship-of-high-sensitivity-c-reactive-protein-concentrations-and-systolic-heart-failure
#14
Sheng Kang, Lie-Ying Fan, Ming Chen, Jue Li, Zhong-Min Liu
Objective Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF. Methods In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed...
April 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28384560/very-low-dose-fluvastatin-valsartan-combination-decreases-parameters-of-inflammation-and-oxidative-stress-in-patients-with-type-1-diabetes-mellitus
#15
Mojca Lunder, Miodrag Janić, Vedran Savić, Andrej Janež, Karin Kanc, Mišo Šabovič
AIMS: Previously we revealed the effectiveness of a new therapeutic approach with a short-term, very-low dose fluvastatin-valsartan combination on the improvement of arterial function in type 1 diabetes mellitus patients (T1DM). In this study we explored whether this approach influences inflammation and oxidative stress and explored any association of these effects with arterial function improvement. METHODS: This was a supplementary analysis of the two previous double blind randomized studies (included 44 T1DM patients)...
March 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28384165/ramadan-fasting-in-saudi-arabia-is-associated-with-altered-expression-of-clock-dusp-and-il-1alpha-genes-as-well-as-changes-in-cardiometabolic-risk-factors
#16
Ghada M A Ajabnoor, Suhad Bahijri, Noor Ahmad Shaik, Anwar Borai, Aliaa A Alamoudi, Jumana Y Al-Aama, George P Chrousos
BACKGROUND: During the fasting month of Ramadan, practicing Saudis develop severe disturbances in sleeping and feeding patterns. Concomitantly, cortisol circadian rhythm is abolished, diurnal cortisol levels are elevated and circulating levels of several adipokines are altered favouring insulin resistance. AIM: To examine changes in the expression of CLOCK and glucocorticoid-controlled genes, such as DUSP1 and IL-1α in Saudi adults before and during Ramadan, and to investigate possible associations with selected cardiometabolic risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28381225/pregnancy-associated-plasma-protein-a-is-a-stronger-predictor-for-adverse-cardiovascular-outcomes-after-acute-coronary-syndrome-in-type-2-diabetes-mellitus
#17
Wei-Ping Li, Moni B Neradilek, Fu-Sheng Gu, Daniel A Isquith, Zhi-Jun Sun, Xing Wu, Hong-Wei Li, Xue-Qiao Zhao
BACKGROUND: The risk prediction of pregnancy-associated plasma protein-A (PAPP-A) for future cardiovascular (CV) events post acute coronary syndrome (ACS) in patients with type-2 diabetes mellitus (T2DM) was investigated in comparison to other risk factors. METHODS: PAPP-A was measured at hospital admission in 320 consecutive ACS patients (136 with T2DM and 184 without). All patients were followed for 2 years for occurrence of CV death, non-fatal MI or stroke. Effect of PAPP-A on the CV event risk was estimated using Cox regression models...
April 5, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28378522/plasminogen-activator-inhibitor-1-is-associated-with-leukocyte-telomere-length-in-american-indians-findings-from-the-strong-heart-family-study
#18
Hao Peng, Fawn Yeh, Jue Lin, Lyle G Best, Shelley A Cole, Elisa T Lee, Barbara V Howard, Jinying Zhao
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) promotes cellular aging both in vitro and in vivo. Telomere length is a marker of biological aging. OBJECTIVES: To examine the cross-sectional and longitudinal associations between plasma PAI-1 and leukocyte telomere length in a large-scale epidemiological study of American Indians. METHODS: We measured leukocyte telomere length (LTL) and plasma PAI-1 in 2,560 American Indians who were free of overt CVD and participated in the Strong Heart Family Study (SHFS) clinical exam in 2001-2003...
April 5, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28377558/pentraxin-3-as-a-new-indicator-of-cardiovascular%C3%A2-related-death-in-patients-with-advanced-chronic-kidney-disease
#19
Marcin Krzanowski, Katarzyna Krzanowska, Mariusz Gajda, Paulina Dumnicka, Artur Dziewierz, Karolina Woziwodzka, Jan A Litwin, Władysław Sułowicz
INTRODUCTION    Pentraxin3 (PTX3) play an important role in the inflammatory response, taking part in recognizing pathogens and damaged tissues. OBJECTIVES    The aim of the study was to assess the relationship between PTX3 levels and all-cause and cardiovascular (CV) mortality in chronic kidney disease (CKD) patients during five-year observation period.  PATIENTS AND METHODS    The study comprised 78 patients (51 hemodialyzed, 27 predialysis). The examined parameters included PTX3, calcium, phosphate, iPTH, interleukin-6 (IL-6), fibroblast growth factor 23 (FGF-23), osteopontin (OPN), osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), osteoprotegerin (OPG), osteocalcin, tumor necrosis factor receptor II (TNF-R II), transforming growth factor-β (TGF-β), hepatocyte growth factor (HGF), stromal cell-derived factor α (SDF1α), and thrombomodulin (TM)...
February 27, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28376792/dietary-inflammatory-index-and-risk-of-first-myocardial-infarction-a-prospective-population-based-study
#20
Stina Bodén, Maria Wennberg, Bethany Van Guelpen, Ingegerd Johansson, Bernt Lindahl, Jonas Andersson, Nitin Shivappa, James R Hebert, Lena Maria Nilsson
BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up...
April 4, 2017: Nutrition Journal
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