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https://www.readbyqxmd.com/read/28923188/poor-sleep-moderates-the-relationship-between-daytime-napping-and-inflammation-in-black-and-white-men
#1
Karen P Jakubowski, Jennifer M Boylan, Jenny M Cundiff, Karen A Matthews
OBJECTIVES: To test whether napping was associated with 2 inflammatory markers with known relationships to cardiovascular disease: high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). Because IL-6 is known to impact central inflammatory processes that relate to sleep regulation, including subjective fatigue, we tested whether this relationship was moderated by sleep duration, sleep efficiency, and self-reported sleep quality. DESIGN: Cross-sectional...
October 2017: Sleep Health
https://www.readbyqxmd.com/read/28922371/the-association-between-cigarette-smoking-and-inflammation-the-genetic-epidemiology-network-of-arteriopathy-genoa-study
#2
Martin Tibuakuu, Daisuke Kamimura, Sina Kianoush, Andrew P DeFilippis, Mahmoud Al Rifai, Lindsay M Reynolds, Wendy B White, Kenneth R Butler, Thomas H Mosley, Stephen T Turner, Iftikhar J Kullo, Michael E Hall, Michael J Blaha
To inform the study and regulation of emerging tobacco products, we sought to identify sensitive biomarkers of tobacco-induced subclinical cardiovascular damage by testing the cross-sectional associations of smoking with 17 biomarkers of inflammation in 2,702 GENOA study participants belonging to sibships ascertained on the basis of hypertension. Cigarette smoking was assessed by status, intensity (number of cigarettes per day), burden (pack-years of smoking), and time since quitting. We modeled biomarkers as geometric mean (GM) ratios using generalized estimating equations (GEE)...
2017: PloS One
https://www.readbyqxmd.com/read/28914081/c-reactive-protein-is-associated-with-prevalence-of-the-metabolic-syndrome-hypertension-and-diabetes-mellitus-in-us-adults
#3
Mohsen Mazidi, Peter P Toth, Maciej Banach
The prevalence of metabolic syndrome (MetS) has increased globally and is associated with an increased risk of cardiovascular diseases that may be related to its association with inflammation. We have assessed whether the prevalence of the MetS correlates with a serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of US men and women. Participants were selected from the US National Health and Nutrition Examination Survey from 2005 to 2010. Of the 17 689 participants analyzed, 8607 (48...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28913889/prevalence-and-contributors-to-low-grade-inflammation-in-three-u-s-populations-of-reproductive-age-women
#4
Lindsey A Sjaarda, Rose G Radin, Chandra Swanson, Daniel L Kuhr, Sunni L Mumford, Noya Galai, Robert M Silver, Jean Wactawski-Wende, Neil J Perkins, Enrique F Schisterman
BACKGROUND: Inflammation, measured by high-sensitivity C-reactive protein (hsCRP), is linked to adverse reproductive outcomes. However, prevalence and predictors of low-grade inflammation are poorly understood among reproductive age women. Therefore, the current aim was to characterize: (i) the prevalence of elevated hsCRP and (ii) whether the association of various demographic, anthropometric, life style, and metabolic characteristics with higher hsCRP varies across populations of reproductive age women with varying risk profiles for adverse reproductive outcomes...
September 15, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28905172/n-terminal-pro-b-type-natriuretic-peptide-and-the-risk-of-stroke-among-patients-hospitalized-with-acute-heart-failure-an-apex-trial-substudy
#5
Gerald Chi, James L Januzzi, Serge Korjian, Yazan Daaboul, Samuel Z Goldhaber, Adrian F Hernandez, Russell D Hull, Alex Gold, Alexander T Cohen, Robert A Harrington, C Michael Gibson
BACKGROUND: Among patients hospitalized with acute heart failure (HF), the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in short-term stroke prediction remains unclear. METHODS: In the APEX trial, 7513 patients hospitalized for an acute medical illness were randomized to receive either extended-duration betrixaban (80 mg once daily for 35-42 days) or standard-of-care enoxaparin (40 mg once daily for 10 ± 4 days) for venous thromboprophylaxis...
September 13, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28904431/role-of-gut-derived-uremic-toxins-on-oxidative-stress-and-inflammation-in-patients-with-chronic-kidney-disease
#6
S Gouroju, P V L N Srinivasa Rao, A R Bitla, K S Vinapamula, S M Manohar, S Vishnubhotla
Several cardiovascular disease (CVD) risk factors have been identified among patients with chronic kidney disease (CKD). Gut-derived uremic toxins (GDUT) are important modifiable contributors in this respect. There are very few Indian studies on GDUT changes in CKD. One hundred and twenty patients older than 18 years diagnosed with CKD were enrolled along with forty healthy subjects. The patients were classified into three groups of forty patients based on stage of CKD. Indoxyl sulfate (IS), para cresyl sulfate (p-CS), indole acetic acid (IAA), and phenol were estimated along with the assessment of oxidative stress (OS), inflammatory state, and bone mineral disturbance...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28903122/impact-of-ixekizumab-treatment-on-depressive-symptoms-and-systemic-inflammation-in-patients-with-moderate-to-severe-psoriasis-an-integrated-analysis-of-three-phase-3-clinical-studies
#7
Christopher E M Griffiths, Maurizio Fava, Andrew H Miller, James Russell, Susan G Ball, Wen Xu, Nayan Acharya, Mark Hyman Rapaport
BACKGROUND: Depression is a common comorbidity in psoriasis, and both conditions are associated with systemic inflammation. The efficacy of ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin (IL)-17A, was evaluated in patients with moderate-to-severe plaque psoriasis (psoriasis) and depressive symptoms that were at least moderately severe. METHODS: Data were integrated from 3 randomized, double-blind, controlled phase 3 trials. At baseline and week 12, depressive symptoms and inflammation were assessed by the 16-item Quick Inventory of Depressive Symptomology - Self-Report (QIDS-SR16) and by a high-sensitivity assay of serum C-reactive protein (hsCRP), respectively...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28895641/relationship-between-oxidative-stress-inflammation-and-dyslipidemia-with-fatty-liver-index-in-patients-with-type-2-diabetes-mellitus
#8
Aleksandra Klisic, Aleksandra Isakovic, Gordana Kocic, Nebojsa Kavaric, Milovan Jovanovic, Elvir Zvrko, Verica Skerovic, Ana Ninic
Introduction/Aim Considering the high prevalence of non-alcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9% females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained...
September 11, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28892878/role-of-anthropometric-measurements-in-development-of-cvd-and-stroke-among-t2dm-in-east-godavari-district-andhra-pradesh-india
#9
Mortha Kiran Deedi, Alavala Matta Reddy, Nelakuditi Lakshmana Kumar
INTRODUCTION: Cardiovascular morbidity and mortality have been associated with different variables of anthropometric measurements. AIM: To find out the association of anthropometric measurements in the development of Cardiovascular Disease (CVD) and stroke among Type 2 Diabetes Mellitus (T2DM). MATERIALS AND METHODS: Three hundred subjects were included in the study out of which 100 subjects were known type 2 diabetics with CVD or Stroke (Group 1), 100 subjects were type 2 diabetic patients (Group 2) and 100 subjects were normal and healthy (Group 3)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28884122/advanced-oxidation-protein-products-and-carbonylated-proteins-as-biomarkers-of-oxidative-stress-in-selected-atherosclerosis-mediated-diseases
#10
Bogna Gryszczyńska, Dorota Formanowicz, Magdalena Budzyń, Maria Wanic-Kossowska, Elżbieta Pawliczak, Piotr Formanowicz, Wacław Majewski, Krzysztof Wojciech Strzyżewski, Magdalena P Kasprzak, Maria Iskra
OBJECTIVES: The main question of this study was to evaluate the intensity of oxidative protein modification shown as advanced oxidation protein products (AOPP) and carbonylated proteins, expressed as protein carbonyl content (C=O) in abdominal aortic aneurysms (AAA), aortoiliac occlusive disease (AIOD), and chronic kidney disease (CKD). DESIGN AND METHODS: The study was carried out in a group of 35 AAA patients and 13 AIOD patients. However, CKD patients were divided into two groups: predialysis (PRE) included 50 patients or hemodialysis (HD) consisted of 34 patients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28877589/may-questionnaire-based-anti-inflammatory-diet-index-predict-low-grade-systemic-inflammation
#11
Joanna Kaluza, Holly Harris, Hakan Melhus, Karl Michaëlsson, Alicja Wolk
There is accumulating evidence that diet may be associated with markers of inflammation. We have evaluated if empirically developed questionnaire-based an Anti-Inflammatory Diet Index (AIDI) may predict low-grade systemic chronic inflammation in a Nordic population. The AIDI was developed using a 123-item food frequency questionnaire among 3,503 women (56-74 years old) with high-sensitivity C-reactive protein (hsCRP) plasma concentration <20 mg/L. Using Spearman correlations we identified 20 foods (AIDI-20) statistically significantly related to hsCRP...
September 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28876961/vitamin-d-replacement-improves-tear-osmolarity-in-patients-with-vitamin-d-deficiency
#12
Muhammed Kizilgul, Seyfullah Kan, Ozgur Ozcelik, Selvihan Beysel, Mahmut Apaydin, Bekir Ucan, Erman Cakal
BACKGROUND: Vitamin D deficiency is a common health problem worldwide. Many parts of the human eye, including the epithelium of the cornea, lens, ciliary body, and retinal pigment epithelium, as well as the corneal endothelium, ganglion cell layer, and retinal photoreceptors, contain vitamin D receptor (VDR). Dry eye is also a common health problem. An adequate tear film is required for maintaining health and function of the eye. Tear hyperosmolarity is considered to be the cause of ocular surface inflammation, symptoms, and tissue damage...
September 6, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28860735/skin-condition-and-its-relationship-to-systemic-inflammation-in-chronic-obstructive-pulmonary-disease
#13
Sebastian Majewski, Anna Pietrzak, Damian Tworek, Karolina Szewczyk, Anna Kumor-Kisielewska, Zofia Kurmanowska, Paweł Górski, Anna Zalewska-Janowska, Wojciech Jerzy Piotrowski
BACKGROUND: The systemic (extrapulmonary) effects and comorbidities of chronic obstructive pulmonary disease (COPD) contribute substantially to its burden. The supposed link between COPD and its systemic effects on distal organs could be due to the low-grade systemic inflammation. The aim of this study was to investigate whether the systemic inflammation may influence the skin condition in COPD patients. MATERIALS AND METHODS: Forty patients with confirmed diagnosis of COPD and a control group consisting of 30 healthy smokers and 20 healthy never-smokers were studied...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28855077/effect-of-interleukin-1%C3%AE-inhibition-with-canakinumab-on-incident-lung-cancer-in-patients-with-atherosclerosis-exploratory-results-from-a-randomised-double-blind-placebo-controlled-trial
#14
Paul M Ridker, Jean G MacFadyen, Tom Thuren, Brendan M Everett, Peter Libby, Robert J Glynn
BACKGROUND: Inflammation in the tumour microenvironment mediated by interleukin 1β is hypothesised to have a major role in cancer invasiveness, progression, and metastases. We did an additional analysis in the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), a randomised trial of the role of interleukin-1β inhibition in atherosclerosis, with the aim of establishing whether inhibition of a major product of the Nod-like receptor protein 3 (NLRP3) inflammasome with canakinumab might alter cancer incidence...
August 25, 2017: Lancet
https://www.readbyqxmd.com/read/28846611/high-intensity-exercise-can-it-protect-you-from-a-fast-food-diet
#15
Christian Duval, Marc-Antoine Rouillier, Rémi Rabasa-Lhoret, Antony D Karelis
The purpose of this study was to assess the ability of high intensity exercise to counteract the deleterious effects of a fast food diet on the cardiometabolic profile of young healthy men. Fifteen men were subjected to an exclusive fast food diet from a popular fast food restaurant chain (three extra value meals/day + optional snack) for 14 consecutive days. Simultaneously, participants were asked to perform each day high intensity interval training (HIIT) (15 × 60 sec sprint intervals (~90% of maximal heart rate)) on a treadmill...
August 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28835163/an-epigenome-wide-association-study-of-inflammatory-response-to-fenofibrate-in-the-genetics-of-lipid-lowering-drugs-and-diet-network
#16
Nabiha Yusuf, Bertha Hidalgo, Marguerite R Irvin, Jin Sha, Degui Zhi, Hemant K Tiwari, Devin Absher, Donna K Arnett, Stella W Aslibekyan
AIM: Fenofibrate, a PPAR-α inhibitor used for treating dyslipidemia, has well-documented anti-inflammatory effects that vary between individuals. While DNA sequence variation explains some of the observed variability in response, epigenetic patterns present another promising avenue of inquiry due to the biological links between the PPAR-α pathway, homocysteine and S-adenosylmethionine - a source of methyl groups for the DNA methylation reaction. HYPOTHESIS: DNA methylation variation at baseline is associated with the inflammatory response to a short-term fenofibrate treatment...
September 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28819125/inflammation-and-bone-mineral-density-a-mendelian-randomization-study
#17
Jian V Huang, C Mary Schooling
Osteoporosis is a common age-related disorder leading to an increase in osteoporotic fractures and resulting in significant suffering and disability. Inflammation may contribute to osteoporosis, as it does to many other chronic diseases. We examined whether inflammation is etiologically relevant to osteoporosis, assessed from bone mineral density (BMD), as a new potential target of intervention, or whether it is a symptom/biomarker of osteoporosis. We obtained genetic predictors of inflammatory markers from genome-wide association studies and applied them to a large genome wide association study of BMD...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814835/efficacy-and-tolerability-of-two-different-formulations-of-atorvastatin-in-korean-patients-with-hypercholesterolemia-a-multicenter-prospective-randomized-clinical-trial
#18
Ju-Hee Lee, Sang-Hyun Kim, Dong-Ju Choi, Seung-Jea Tahk, Jung-Han Yoon, Si Wan Choi, Taek-Jong Hong, Hyo-Soo Kim
PURPOSE: This study was designed to compare the efficacy and tolerability of the generic formulation (Atorva(®)) and the reference formulation (Lipitor(®)) of atorvastatin, both at a dosage of 20 mg once daily. METHODS: This study was a prospective open-label, randomized controlled study. Hypercholesterolemic patients who had not achieved low-density lipoprotein (LDL) cholesterol goals according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guideline were randomized to generic formulation or reference formulation of atorvastatin...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28807718/autonomic-regulation-of-systemic-inflammation-in-humans-a-multi-center-blinded-observational-cohort-study
#19
Gareth L Ackland, Gary Minto, Martin Clark, John Whittle, Robert C M Stephens, Thomas Owen, Pradeep Prabhu, Ana Gutierrez Del Arroyo
OBJECTIVE: Experimental animal models demonstrate that autonomic activity regulates systemic inflammation. By contrast, human studies are limited in number and exclusively use heart rate variability (HRV) as an index of cardiac autonomic regulation. HRV measures are primarily dependent on, and need to be corrected for, heart rate. Thus, independent autonomic measures are required to confirm HRV-based findings. Here, the authors sought to replicate the findings of preceding HRV-based studies by using HRV-independent, exercise-evoked sympathetic and parasympathetic measures of cardiac autonomic regulation to examine the relationship between autonomic function and systemic inflammation...
August 12, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28801280/-regression-analysis-of-red-cell-distribution-width-and-mean-platelet-volume-in-patients-with-acute-myocardial-infarction
#20
Qi Liang, Xin-Jun Lei, Hong-Bing Li, Yang-Rong Yin, Jie Ren, Li-Hong Fan, Xin Huang, Zu-Yi Yuan
OBJECTIVE: To investigate clinical implications of changes in red cell distribution width (RDW) and mean platelet volume (MPV) in patients with acute myocardial infarction. METHODS: A total of 127 patients (90 men and 37 women) were enrolled in this analysis, including 66 with acute myocardial infarction (AMI) and 61 with unstable angina (UA). The patients' baseline demographic and clinical data were compared between the two groups including age, hypertension, diabetes, smoking, BMI, blood biochemical profiles, cardiac functions and platelet and red blood cell parameters...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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