keyword
MENU ▼
Read by QxMD icon Read
search

miRNA diabetes

keyword
https://www.readbyqxmd.com/read/28101643/polymorphisms-in-genes-encoding-mir-155-and-mir-146a-are-associated-with-protection-to-type-1-diabetes-mellitus
#1
Taís S Assmann, Guilherme C K Duarte, Letícia A Brondani, Pedro H O de Freitas, Égina M Martins, Luís H Canani, Daisy Crispim
AIMS: Type 1 diabetes mellitus (T1DM) is characterized by severe autoimmune destruction of pancreatic beta-cells. The triggering of autoimmunity against beta-cells is probably caused by a combination of environmental and genetic risk factors. Even though much is known about the genetic of T1DM, more information is needed to completely unravel this tangled disease. MicroRNAs (miRNAs) are a class of small noncoding RNAs molecules that negatively regulate gene expression by inducing target mRNA cleavage or by inhibiting protein translation...
January 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28097875/mirna-profiling-for-the-early-detection-and-clinical-monitoring-of-diabetic-kidney-disease
#2
Johanna K DiStefano
No abstract text is available yet for this article.
January 18, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28070856/mir-29c-prkci-regulates-axonal-growth-of-dorsal-root-ganglia-neurons-under-hyperglycemia
#3
Longfei Jia, Lei Wang, Michael Chopp, Chao Li, Yi Zhang, Alexandra Szalad, Zheng Gang Zhang
Diabetes initially induces distal axonal damage of peripheral nerves, but molecular mechanisms that mediate axonal injury are not fully understood. MircoRNAs (miRNAs) regulate axonal growth. We found that diabetic db/db mice exhibited substantial upregulation of miR-29c in dorsal root ganglia (DRG) neurons, sciatic nerve, and foot pad tissues. Bioinformatic analysis revealed PRKCI, a gene that encodes a member of the protein kinase C (PKC) iota, as a putative target for miR-29c. Western blot analysis showed that diabetic mice exhibited a considerable reduction of PRKCI protein levels in sciatic nerve tissues and DRG neurons...
January 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28060535/circulating-micrornas-promising-biomarkers-involved-in-several-cancers-and-other-diseases
#4
Yicheng Zhao, Yuanyuan Song, Li Yao, Guangqi Song, Chunbo Teng
Recently, many studies indicated that microRNAs (miRNAs) stably existed in various body fluids, including serum, plasma, saliva, and urine. Such miRNAs that exist in mammalian body fluids are known as circulating miRNAs, and they can transmit signals between cells and regulate intracellular gene expression. Currently, we barely understand the characteristics, sources, secretion, uptake, and functions of newly generated miRNAs. Particularly, it has been shown that certain types of circulating miRNAs can provide effective clinical data, suggesting their roles as novel biomarkers for the early detection of diseases such as cancers, cardiovascular diseases, and diabetes...
January 6, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28057086/diagnostic-value-of-microrna-143-in-predicting-in-stent-restenosis-for-patients-with-lower-extremity-arterial-occlusive-disease
#5
Zhi-Hai Yu, Hai-Tao Wang, Can Tu
PURPOSE: This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting in-stent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD). METHODS: From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography...
January 5, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28053239/microrna-378-reduces-mesangial-hypertrophy-and-kidney-tubular-fibrosis-via-mapk-signaling
#6
Bo Wang, Kevin Yao, Andrea F Wise, Ricky Lau, Hsin-Hui Shen, Greg H Tesch, Sharon D Ricardo
AIMS: To determine the regulatory role of a novel miRNA, miR-378, in the development of fibrosis through repression of the MAPK1 (ERK2) pathway. METHODS: miR-378 and fibrotic gene expression was examined in streptozotocin (STZ)-induced diabetic mice at 18 weeks or in unilateral ureteral obstruction (UUO) mice at 7 days. miR-378 transfection of proximal tubular epithelial cells, NRK52E, and mesangial cells was assessed with/without endogenous miR-378 knockdown using the locked nucleic acid (LNA) inhibitor...
January 4, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28045889/metformin-induces-growth-inhibition-and-cell-cycle-arrest-by-upregulating-microrna34a-in-renal-cancer-cells
#7
Wei Xie, Lei Wang, Halei Sheng, Jing Qiu, Di Zhang, Le Zhang, Fan Yang, Dahai Tang, Kebin Zhang
BACKGROUND Metformin is a widely used biguanide drug for the treatment of type 2 diabetes. It has been revaluated as a potential anti-cancer drug with promising activity in various tumors. However, the precise mechanisms underlying the suppression of cancer cells by metformin remain not well understood. MATERIAL AND METHODS In this study, human renal cell carcinoma cell line ACHN was used to investigate the anti-proliferation effect of metformin. A cell counting kit-8 assay was used to detect the cell viability...
January 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28044409/macro-and-microvascular-endothelial-dysfunction-in-diabetes
#8
REVIEW
Yi Shi, Paul M Vanhoutte
Endothelial cells, as well as their major products nitric oxide and prostacyclin, play a key role in the regulation of vascular homeostasis. Diabetes mellitus is an important risk factor for cardiovascular disease. Diabetes-induced endothelial dysfunction is a critical and initiating factor in the genesis of diabetic vascular complications. The present review focuses on both large blood vessels and the microvasculature. The endothelial dysfunction in diabetic macrovascular complications is characterized by a reduced nitric oxide bioavailability, poorly compensated for by increased production of prostacyclin and/or endothelium-dependent hyperpolarizations, and increased production /action of endothelium-derived vasoconstrictors...
January 3, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28040802/dysregulated-long-intergenic-non-coding-rna-modules-contribute-to-heart-failure
#9
Lin Pang, Jing Hu, Guanxiong Zhang, Xiang Li, Xinxin Zhang, Fulong Yu, Yujia Lan, Jinyuan Xu, Bo Pang, Dong Han, Yun Xiao, Xia Li
Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulatory molecules involved in diseases including heart failure. However, little is known about how the lincRNAs work together with protein-coding genes (PCGs) contributing to the pathogenesis of heart failure. In this study, we constructed a comprehensive transcriptome profile of lincRNAs, PCGs and miRNAs using RNA-seq and miRNA-seq data of 16 heart failure patients (HFs) and 8 non-failing individuals (NFs). Through integrating lincRNA and PCG expression profiles, we identified HF-associated lincRNA modules...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/28017719/repression-of-mir-217-protects-against-high-glucose-induced-podocyte-injury-and-insulin-resistance-by-restoring-pten-mediated-autophagy-pathway
#10
Juan Sun, Zhao Pin Li, Rui Qin Zhang, Hui Min Zhang
Podocyte damage is the initial hallmark of diabetic nephropathy (DN), leading to the increasing morbidity and mortality in diabetic patients. Recent researches have corroborated the critical roles of miRNAs in the pathological progression of DN. Here, elevation of miR-217 was verified in high glucose (HG)-stimulated podocytes. Moreover, blocking miR-217 expression antagonized HG-induced cell injury by attenuating the adverse role of HG on cell viability and inhibiting ROS levels and cell apoptosis. Simultaneously, miR-217 repression restored HG-disrupted insulin resistance by elevating glucose uptake and nephrin expression, an essential component for insulin-induced glucose uptake...
December 23, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28008641/effects-of-mirnas-on-myocardial-apoptosis-by-modulating-mitochondria-related-proteins
#11
REVIEW
Yanfang Zhao, Murugavel Ponnusamy, Yanhan Dong, Lei Zhang, Kun Wang, Peifeng Li
Myocardial apoptosis play a vital role in pathogenesis of cardiovascular diseases. The intrinsic pathway of apoptosis (mitochondrial apoptosis pathway) and abnormal mitochondrial fission and fusion have a detrimental effect on cells under a variety of intracellular stresses including hypoxia, oxidative stress, drug toxicity or DNA damage and contributes to the development of heart failure (HF), myocardial infarction (MI), diabetic cardiomyopathy and ischemia/reperfusion injury (I/R). MicroRNAs (miRNAs) are endogenous short noncoding RNAs, which target 3'-untranslated region of mRNA to switch off gene expression...
December 23, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28003969/expression-and-regulation-of-microrna-29a-and-microrna-29c-in-early-diabetic-rat-cataract-formation
#12
Ying Sun, Chun-Mei Lu, Zhen Song, Ke-Ke Xu, Shu-Bin Wu, Zhi-Jian Li
AIM: To determine the role of microRNA (miRNA)-29a and miRNA-29c in the regulation of apoptosis in early rat diabetic cataract formation. METHODS: Streptozotocin (STZ)-induced diabetic Sprague-Dawley (SD) rats were used in the study. The expression level of miRNA-29a, miRNA-29c, and BCL2-modifying factor (BMF) in lens epithelial cells (LECs) samples were measured using quantitative real-time polymerase chain reaction. Prediction algorithms of miRanda, TargetScan 6...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28000458/relationship-between-social-support-networks-and-diabetes-control-and-its-impact-on-the-quality-of-life-in-older-community-dwelling-mexicans
#13
Víctor Manuel Mendoza-Núñez, Cristina Flores-Bello, Elsa Correa-Muñoz, Raquel Retana-U Galde, Mirna Ruiz-Ramos
OBJECTIVE: To determine the relationship between social support networks and diabetes control and its impact on quality of life in older community-dwelling Mexicans. METHODS: A cross-sectional study was carried out on a convenience sample of 182 older diabetic people who were active participants in community self-care and mutual help groups in Mexico City for more than one year. All were independents and had medical diagnostics determining that they had diabetes without complications for one year or more...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28000044/dysregulation-between-trim63-fbxo32-expression-and-soleus-muscle-wasting-in-diabetic-rats-potential-role-of-mir-1-3p-29a-b-3p-and-133a-b-3p
#14
Frederico Gerlinger-Romero, Caio Yogi Yonamine, Danilo Correa Pinto Junior, João Victor DelConti Esteves, Ubiratan Fabres Machado
Diabetes mellitus (DM) induces a variable degree of muscle sarcopenia, which may be related to protein degradation and to the expression of both E3 ubiquitin ligases and some specific microRNAs (miRNAs). The present study investigated the effect of diabetes and acute muscle contraction upon the TRIM63 and FBXO32 expression as well as the potential involvement of some miRNAs. Diabetes was induced by streptozotocin and studied after 30 days. Soleus muscles were harvested, stimulated to contract in vitro for twitch tension analysis (0...
December 20, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27998767/maternal-exosomes-in-diabetes-contribute-to-the-cardiac-development-deficiency
#15
Ruijing Shi, Lianbi Zhao, Wenbin Cai, Mengying Wei, Xueying Zhou, Guodong Yang, Lijun Yuan
Maternal diabetes mellitus induces an increased risk of congenital heart defects (CHD), however, the exact mechanisms are still not fully illustrated. In this study, diabetic pregnant C57BL/6 mice were induced by injection of streptozotocin before mating. Compared with the control normal mice, diabetic pregnant mice displayed significant changes of the exosomal miRNA contents in the blood, as revealed by RNA-seq analysis. Multiple of these miRNAs were found involved in cardiac development regulation. Moreover, fluorescence labeled exosomes and gold nanoparticles could cross the placenta barrier and infiltrated into the embryonic organs/tissues, including the heart, during embryonic development...
December 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27995171/microrna-expression-analysis-in-the-liver-of-high-fat-diet-induced-obese-mice
#16
Won-Mo Yang, Kyung-Ho Min, Wan Lee
A previous study indicated a causal link between certain miRNAs induced by obesity and the development of hepatic insulin resistance and type 2 diabetes. Here we provide accompanying data collected using Affymetrix GeneChip miRNAs microarrays to identify the changes in miRNAs expression in the liver of mice fed a high fat diet (HFD). Differentially expressed microRNA analyses in the liver of the HFD-fed mice revealed a range of upregulated (>1.5-fold) or downregulated (<0.5-fold) miRNAs. Among those upregulated miRNAs, in silico target analysis, such as TargetScan, PicTar, and miRWalk, identified miRNAs with the putative binding sites on the 3'UTRs of INSR and/or IRS-1...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27994634/serum-microrna-profiling-and-bioinformatics-of-patients-with-spleen-deficiency-syndrome
#17
Ze-Min Yang, Long-Hui Chen, Min Hong, Ying-Yu Chen, Xiao-Rong Yang, Si-Meng Tang, Qian-Fa Yuan, Zhen-Yu He, Wei-Wen Chen
To investigate serum microRNA (miRNA) profile and bioinformatics of patients with spleen-deficiency syndrome (SDS) and explore pathogenesis of SDS patients from miRNA levels, 10 patients with type 2 diabetes mellitus (T2DM), within which 5 patients were with SDS and the remaining were with blood stasis syndrome (BSS), and 5 healthy volunteers were recruited. Serum miRNA profiles of SDS patients were identified by quantitative PCR array. Target prediction and functional annotation for miRNAs were performed by miRSystem database...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27993686/microrna-126-suppresses-inflammation-in-endothelial-cells-under-hyperglycemic-condition-by-targeting-hmgb1
#18
Song-Tao Tang, Feng Wang, Min Shao, Yuan Wang, Hua-Qing Zhu
MicroRNA-126(miR-126) targets involved in inflammation need to be identified. In this study, we aim to investigate whether high-mobility group box 1(HMGB1), an inflammation-related gene, is the target of miR-126 in diabetic vascular endothelium. The diabetic apoE(-/-) mice model, a classical diabetic atherosclerosis model, was established. The aorta of diabetic apoE(-/-) mice showed decrease of miR-126 and elevation of HMGB1 and inflammation. Next, we employed several in vitro experiments to address the role of miRNA-126 on the regulation of HMGB1 in endothelial cells under hyperglycemic and inflammatory conditions...
December 18, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27989505/endothelial-mirnas-as-cellular-messengers-in-cardiometabolic-diseases
#19
REVIEW
Makon-Sébastien Njock, Jason E Fish
Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the underlying mechanisms will advance the development of diagnostic and therapeutic approaches. A prominent feature of cardiometabolic diseases is endothelial dysfunction. Endothelial cell (EC) homeostasis and response to pathological stimuli are controlled by gene regulatory networks in which miRNAs play a critical role...
December 15, 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27987357/micrornas-in-lipoprotein-and-lipid-metabolism-from-biological-function-to-clinical-application
#20
Véronique Desgagné, Luigi Bouchard, Renée Guérin
microRNAs (miRNAs) are short (~22 nucleotides), non-coding, single-stranded RNA molecules that regulate the expression of target genes by partial sequence-specific base-pairing to the targeted mRNA 3'UTR, blocking its translation, and promoting its degradation or its sequestration into processing bodies. miRNAs are important regulators of several physiological processes including developmental and metabolic functions, but their concentration in circulation has also been reported to be altered in many pathological conditions such as familial hypercholesterolemia, cardiovascular diseases, obesity, type 2 diabetes, and cancers...
December 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
keyword
keyword
3857
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"