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miRNA diabetes

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https://www.readbyqxmd.com/read/29773082/no-detectable-differential-microrna-expression-between-non-atherosclerotic-arteries-of-type-2-diabetic-patients-treated-or-untreated-with-metformin-and-non-diabetic-patients
#1
Lasse Bach Steffensen, Søren Feddersen, Simone Rørdam Preil, Lars Melholt Rasmussen
BACKGROUND: Type 2 diabetes mellitus (T2DM) is an independent risk factor of cardiovascular disease (CVD), however, the underlying mechanisms are largely unknown. Using non-atherosclerotic internal thoracic arteries (ITAs) obtained from coronary artery bypass grafting, we previously identified a distinct elevation in the level of proteins comprising the arterial basement membrane in T2DM patients not treated with metformin. Altered transcription of genes encoding these proteins has not been observed, indicating alternative mechanisms of dysregulation...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29770126/crosstalk-between-the-unfolded-protein-response-micrornas-and-insulin-signaling-pathways-in-search-of-biomarkers-for-the-diagnosis-and-treatment-of-type-2-diabetes
#2
REVIEW
Chinar Berry, Megha Lal, B K Binukumar
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by functional defects in glucose metabolism and insulin secretion. Its complex etiology and multifaceted nature have made it difficult to design effective therapies for early diagnosis and treatment. Several lines of evidence indicate that aberrant activation of the unfolded protein response (UPR) in response to endoplasmic reticulum (ER) stress impairs the β cell's ability to respond to glucose and promotes apoptosis. Elucidating the molecular mechanisms that govern β cell dysfunction and cell death can help investigators design therapies to halt or prevent the development of T2DM...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29765562/a-myriad-of-roles-of-mir-25-in-health-and-disease
#3
REVIEW
Márta Sárközy, Zsuzsanna Kahán, Tamás Csont
Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in different predicted target mRNAs...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754174/targeting-mirna-for-therapy-of-juvenile-and-adult-diabetic-cardiomyopathy
#4
Shyam Sundar Nandi, Paras Kumar Mishra
Prevalence of diabetes mellitus (DM), a multifactorial disease often diagnosed with high blood glucose levels, is rapidly increasing in the world. Association of DM with multi-organ dysfunction including cardiomyopathy makes it a leading cause of morbidity and mortality. There are two major types of DM: type 1 DM (T1D) and type 2 DM (T2D). T1D is diagnosed by reduced levels of insulin and high levels of glucose in the blood. It is caused due to pancreatic beta cell destruction/loss, and mostly found in juveniles (juvenile DM)...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29752466/mir-5591-5p-regulates-the-effect-of-adscs-in-repairing-diabetic-wound-via-targeting-ages-ager-jnk-signaling-axis
#5
Qiang Li, Sizhan Xia, Yating Yin, Yanping Guo, Feifei Chen, Peisheng Jin
Advanced glycation end products/advanced glycation end products receptor (AGEs/AGER) interaction triggers reactive oxygen species (ROS) generation and activates downstream signal pathways and induces apoptosis in endothelial progenitor cells. A number of studies have revealed the involvement of microRNAs (miRNAs) in regulating intracellular ROS production and apoptosis. However, few studies explore the role of miRNAs in regulating the effect of adipose tissue-derived stem cells (ADSCs) in repairing diabetic wound and the associated cellular mechanisms remain unclear...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29749515/significant-role-of-microrna%C3%A2-219%C3%A2-5p-in-diabetic-retinopathy-and-its-mechanism-of-action
#6
Junying Zhao, Sha Gao, Yanji Zhu, Xi Shen
Diabetic retinopathy (DR) is the leading cause of blindness and visual impairment. The role of microRNA (miRNA) in DR remains largely unknown. The present study aimed to investigate the role of miR‑219‑5p in the progression of DR. Human retinal pigment epithelial (RPE) cells were treated with a high concentration of glucose (50 mM D‑glucose) for 24 h and the miR‑219‑5p level was detected using reverse transcription‑quantitative polymerase chain reaction. The results revealed that miR‑219‑5p was significantly upregulated by high glucose (HG) treatment...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748291/microrna-129-and-335-promote-diabetic-wound-healing-by-inhibiting-sp1-mediated-mmp-9-expression
#7
Wei Wang, Chuan Yang, Xiao Yi Wang, Li Yan Zhou, Guo Juan Lao, Dan Liu, Chuan Wang, Meng Die Hu, Ting Ting Zeng, Li Yan, Meng Ren
Diabetic wounds are recalcitrant to healing. However, the mechanism causing this dysfunction is not fully understood. High expression of matrix metalloproteinase-9 (MMP-9) is indicative of poor wound healing. Here, we show that specificity protein-1 (Sp1), a regulator of MMP-9, binds directly to its promoter and enhances its expression. Additionally, we demonstrated that Sp1 is the direct target of two miRNAs, miR-129 and -335, which are significantly downregulated in diabetic skin tissues. In vitro experiments confirmed that miR-129 or -335 overexpression inhibits MMP-9 promoter activity and protein expression by targeting Sp1, whereas the inhibition of these miRNAs has the opposite effect...
May 10, 2018: Diabetes
https://www.readbyqxmd.com/read/29739042/potential-value-of-urinary-exosome-derived-let-7c-5p-in-the-diagnosis-and-progression-of-type-ii-diabetic-nephropathy
#8
Weite Li, Shuo Yang, Rui Qiao, Jie Zhang
BACKGROUND: Diabetic nephropathy (DN) is a leading cause of death worldwide. Reliable biomarkers are demanded for the non-invasive diagnosis of DN. This study aims to investigate whether miRNA in urinary exosomes could serve as a potential biomarker in the diagnosis and progression of DN. METHODS: Urine samples were collected from fifteen healthy controls, twenty type II diabetes without DN and twenty-eight type II patients with DN who underwent kidney biopsy. Differential centrifugation was used to isolate exosomes from urine samples and exosomes were confirmed by electron microscopy, nanoparticle tracking analysis (NTA), and western blot...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29732466/novel-insights-into-the-regulation-of-mirna-transcriptional-control-implications-for-t2d-and-related-complications
#9
Lucia La Sala, Stefano Micheloni, Valeria De Nigris, Francesco Prattichizzo, Antonio Ceriello
In recent years, epigenetics has emerged as an important form of biological regulation involving chromatin control of gene expression. The mechanisms of this fine-tuned regulation are susceptible to changes forced by environmental stimuli and nutritional factors and may be potentially reversible. Dysregulation of epigenetic processes has important consequences for the pathogenesis of complex and multifactorial diseases such as type 2 diabetes (T2D) and vascular complications. Along with DNA methylation (DNA-me), histone modifications and RNA-based mechanisms as the major epigenetic controllers, small non-coding RNAs known as microRNAs (miRNAs) have their own important implications for the pathogenesis of diabetes...
May 7, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29725042/reduced-autophagy-by-a-microrna-mediated-signaling-cascade-in-diabetes-induced-renal-glomerular-hypertrophy
#10
Supriya Deshpande, Maryam Abdollahi, Mei Wang, Linda Lanting, Mitsuo Kato, Rama Natarajan
Autophagy plays a key role in the pathogenesis of kidney diseases, however its role in diabetic nephropathy (DN), and particularly in kidney glomerular mesangial cells (MCs) is not very clear. Transforming Growth Factor- β1 (TGF-β), a key player in the pathogenesis of DN, regulates expression of various microRNAs (miRNAs), some of which are known to regulate the expression of autophagy genes. Here we demonstrate that miR-192, induced by TGF-β signaling, plays an important role in regulating autophagy in DN...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29721017/elevated-and-correlated-expressions-of-mir-24-mir-30d-mir-146a-and-sfrp-4-in-human-abdominal-adipose-tissue-play-a-role-in-adiposity-and-insulin-resistance
#11
Yury O Nunez Lopez, Gabriella Garufi, Magdalena Pasarica, Attila A Seyhan
Objective: We explored the relationships among microRNAs (miRNAs) and SFRP4, as they relate to adipose tissue functions including lipolysis, glucose and glycerol turnover, and insulin sensitivity. Methods: Abdominal adipose tissue (AbdAT) levels of thirteen microRNAs (miRNAs), SFRP4, and VEGF in lean nondiabetic subjects ( n = 7), subjects with obesity ( n = 5), and subjects with obesity and type 2 diabetes (T2DM) ( n = 5) were measured by qPCR. Insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29720943/microrna-200a-200b-modulate-high-glucose-induced-endothelial-inflammation-by-targeting-o-linked-n-acetylglucosamine-transferase-expression
#12
Wan-Yu Lo, Wen-Kai Yang, Ching-Tien Peng, Wan-Yu Pai, Huang-Joe Wang
Background and Aims: Increased O -linked N -acetylglucosamine ( O -GlcNAc) modification of proteins by O -GlcNAc transferase (OGT) is associated with diabetic complications. Furthermore, oxidative stress promotes endothelial inflammation during diabetes. A previous study reported that microRNA-200 (miR-200) family members are sensitive to oxidative stress. In this study, we examined whether miR-200a and miR-200b regulate high-glucose (HG)-induced OGT expression in human aortic endothelial cells (HAECs) and whether miRNA-200a/200b downregulate OGT expression to control HG-induced endothelial inflammation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29717195/author-correction-mirna-29c-regulates-the-expression-of-inflammatory-cytokines-in-diabetic-nephropathy-by-targeting-tristetraprolin
#13
Jia Guo, Jing Li, Jing Zhao, Shuguang Yang, Luyao Wang, Genyang Cheng, Dong Liu, Jing Xiao, Zhangsuo Liu, Zhanzheng Zhao
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29717107/exendin-4-ameliorates-high-glucose-induced-fibrosis-by-inhibiting-the-secretion-of-mir-192-from-injured-renal-tubular-epithelial-cells
#14
Yijie Jia, Zongji Zheng, Meiping Guan, Qian Zhang, Yang Li, Ling Wang, Yaoming Xue
Extracellular vesicles (EVs), which contain microRNA (miRNA), constitute a novel means of cell communication that may contribute to the inevitable expansion of renal fibrosis during diabetic kidney disease (DKD). Exendin-4 is effective for treating DKD through its action on GLP1R. However, the effect of exendin-4 on EV miRNA expression and renal cell communication during the development of DKD remains unknown. In this study, we found that EVs derived from HK-2 cells pre-treated with exendin-4 and high glucose (Ex-HG), which were taken up by normal HK-2 cells, resulted in decreased levels of FN and Col-I compared with EVs from HK-2 cells pre-treated with HG alone...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29707000/microrna-and-microvascular-complications-of-diabetes
#15
REVIEW
F Barutta, S Bellini, R Mastrocola, G Bruno, G Gruden
In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29705125/systematically-analyses-of-the-common-dysregulated-networks-to-understand-the-common-pathologies-between-t2d-and-atherosclerosis
#16
Zijing Lin, Fan Yang, Lijie Sun, Jie Gao, Yan Cao, Hui Qiu, Xiaorong Zhan
BACKGROUND: Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus, causes cerebro-cardiovascular diseases (CVD), which increase the risk of death in patients with DM and significantly reduce their quality of life. Therefore, mechanisms underlying the common shared pathologies between type 2 diabetes (T2D) and atherosclerosis are key to prevention and treatment of diabetic macroangiopathy. However, the common shared pathological links between T2D and atherosclerosis are not fully understood...
April 26, 2018: Gene
https://www.readbyqxmd.com/read/29704494/metformin-a-first-line-drug-for-type-2-diabetes-mellitus-disrupts-the-malat1-mir-142-3p-sponge-to-decrease-invasion-and-migration-in-cervical-cancer-cells
#17
Chenglai Xia, Shaofeng Liang, Zhihong He, Xiaolan Zhu, Ruihong Chen, Jinman Chen
The molecular mechanisms underlying the anti-neoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive. To explore the novel anti-neoplastic mechanisms of metformin, the transwell chamber and wound-healing assays were used to evaluate its effects on the migration and invasion of human cervical cancer cells. Real-time PCR and Western blotting were used to measure the gene and protein expression, respectively, of microRNA (miRNA) miR-142-3p, long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript-1 (MALAT1), and high-mobility group AT-hook 2 (HMGA2)...
April 25, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29689688/swimming-exercise-induced-reversed-expression-of-mir-96-and-its-target-gene-nav1-3-in-diabetic-peripheral-neuropathy-in-rats
#18
Amir Mahmoudi Aghdam, Parviz Shahabi, Elham Karimi-Sales, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Mohammad Reza Alipour
Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy. Recently, the role of microRNA-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Peripheral nerve injuries result in NaV1.3 elevation. Exercise has beneficial role in diabetes management and peripheral neuropathy. However, the effects of exercise on miR-96 and its target gene NaV1.3 in diabetic rats are unknown. Therefore, the present study investigated the effects of exercise training on the expression of miR-96 and NaV1...
April 25, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29680463/a-novel-regulator-of-type-ii-diabetes-microrna-143
#19
REVIEW
Biao Li, Jingjing Fan, Ning Chen
MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143...
April 18, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29679626/microrna-expression-profile-in-plasma-from-type-1-diabetic-patients-case-control-study-and-bioinformatic-analysis
#20
Taís S Assmann, Mariana Recamonde-Mendoza, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Daisy Crispim
AIMS: To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. METHODS: Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR...
April 19, 2018: Diabetes Research and Clinical Practice
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