Asif Ahmed Bhat, Gaurav Gupta, Obaid Afzal, Imran Kazmi, Fahad A Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I Alzarea, Sachin Kumar Singh, Kamal Dua
As the second-oldest atypical antipsychotic, risperidone has a long history of off-label usage for treating behavioural and psychological signs and symptoms of dementia (BPSD), such as agitation, aggressiveness, and psychosis. Risperidone has been shown in several trials to have a statistically significant benefit when used in a therapeutic context. Several lines of evidence suggest a possible role of risperidone via the antagonistic effect of Dopamine D2 and 5HT-receptor in different neurological diseases like cognitive dysfunction of schizophrenia, neuroinflammation, Huntington's disease, and sleep cycle management...
December 7, 2022: Chemico-biological Interactions