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Stearidonic acid

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https://www.readbyqxmd.com/read/29054673/fluvial-biofilms-exposed-to-desiccation-and-pharmaceutical-pollution-new-insights-using-metabolomics
#1
Albert Serra-Compte, Natàlia Corcoll, Belinda Huerta, Sara Rodríguez-Mozaz, Sergi Sabater, Damià Barceló, Diana Álvarez-Muñoz
In many arid and semi-arid systems, biological communities in river ecosystems are submitted to flow interruption and desiccation, as well as to the impact of urban wastewaters. In this work, we studied (using a LC-LTQ-Orbitrap) the metabolomic response of biofilm communities exposed to both hydrological and chemical stressors. Fluvial biofilms were exposed to a mixture of 9 pharmaceuticals at a total concentration of 5000ng/L (mimicking concentrations and compounds found in polluted aquatic environments) and/or to seven days of desiccation, under laboratory conditions...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29048366/lipase-catalyzed-transesterification-of-egg-yolk-phophatidylcholine-with-concentrate-of-n-3-polyunsaturated-fatty-acids-from-cod-liver-oil
#2
Anna Chojnacka, Witold Gładkowski, Aleksandra Grudniewska
Phospholipids containing PUFAs are important vehicles for their delivering to the targeted tissues. In our research project we established enzymatic methods for the enrichment of natural egg-yolk PC with n-3 PUFAs. Instead of synthetic PUFA ethyl esters, the new strategy was developed using polyunsaturated fatty acids enriched fraction (PUFA-EF) from cod liver oil as the natural acyl donors. PUFA-EF was produced by urea-complexation and contained 86.9% PUFA including 8.5% stearidonic acid (SDA; 18:4(n-3)), 26...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28946872/suppression-of-adipocyte-differentiation-and-lipid-accumulation-by-stearidonic-acid-sda-in-3t3-l1-cells
#3
Yueru Li, Yinghui Rong, Lisui Bao, Ben Nie, Guang Ren, Chen Zheng, Rajesh Amin, Robert D Arnold, Ramesh B Jeganathan, Kevin W Huggins
BACKGROUND: Increased consumption of omega-3 (ω-3) fatty acids found in cold-water fish and fish oil has been reported to protect against obesity. A potential mechanism may be through reduction in adipocyte differentiation. Stearidonic acid (SDA), a plant-based ω-3 fatty acid, has been targeted as a potential surrogate for fish-based fatty acids; however, its role in adipocyte differentiation is unknown. This study was designed to evaluate the effects of SDA on adipocyte differentiation in 3T3-L1 cells...
September 25, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28874672/unravelling-a-stearidonic-acid-rich-triacylglycerol-biosynthetic-pathway-in-the-developing-seeds-of-buglossoides-arvensis-a-transcriptomic-landscape
#4
R V Sreedhar, P Prasad, L Prasanna Anjaneya Reddy, Ram Rajasekharan, Malathi Srinivasan
Buglossoides arvensis is an emerging oilseed crop that is rich in stearidonic acid (SDA) and has several potential applications in human health and nutrition. The molecular basis of SDA biosynthesis in this plant remains unknown due to lack of genomic information. To unravel key genes involved in SDA-rich triacylglycerol (TAG) biosynthesis, we performed transcriptome sequencing of pooled mRNA from five different developmental stages of B. arvensis seeds using Illumina NextSeq platform. De novo transcriptome assembly generated 102,888 clustered transcripts from 39...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762000/production-of-%C3%AF-3-fatty-acids-in-marine-cyanobacterium-synechococcus-sp-strain-nkbg-15041c-via-genetic-engineering
#5
Tomoko Yoshino, Natsumi Kakunaka, Yue Liang, Yasuhito Ito, Yoshiaki Maeda, Tatsuhiro Nomaguchi, Tadashi Matsunaga, Tsuyoshi Tanaka
Omega-3 fatty acids (ω3 FAs) have attracted attention because they have various health benefits for humans. Fish oils are currently major sources of ω3 FAs, but a sustainable supply of ω3 FAs based on fish oils is problematic because of the increasing demand. In this study, the production potential of a genetically engineered marine cyanobacterium, Synechococcus sp. strain NKBG 15041c, was examined as an alternative source of ω3 FAs. A change in fatty acid composition of this cyanobacterium was successfully induced by the expression of a heterologous Δ6-desaturase, and the transformants synthesized stearidonic acid, which the wild type cannot produce...
August 1, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28756366/structure-of-unsaturated-fatty-acids-in-2d-system
#6
J L Fidalgo Rodríguez, P Dynarowicz-Latka, J Miñones Conde
The behaviour of Langmuir monolayers corresponding to unsaturated fatty acids belonging to the omega-9 (oleic acid), omega-3 (α-linolenic and stearidonic acids) and omega-6 (linoleic, γ-linolenic and eicosadienoic acids) series was studied in order to get insight into the influence of various factors (such as subphase temperature, length, degree of unsaturation and position of the double bonds in the aliphatic chains) on the molecular conformation of these fatty acids spread at the A/W interface. The obtained results derived from the surface pressure - area isotherms, compressibility modulus and monolayer thickness prove that the lift-off and the limiting areas of investigated films increase both with the number of double bonds and length of the hydrocarbon chain...
October 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28744771/anti-inflammatory-effects-of-stearidonic-acid-mediated-by-suppression-of-nf-%C3%AE%C2%BAb-and-map-kinase-pathways-in-macrophages
#7
Jeehye Sung, Heemang Jeon, In-Hwan Kim, Heon Sang Jeong, Junsoo Lee
Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264...
July 25, 2017: Lipids
https://www.readbyqxmd.com/read/28713595/fatty-acid-profiles-of-stipe-and-blade-from-the-norwegian-brown-macroalgae-laminaria-hyperborea-with-special-reference-to-acyl-glycerides-polar-lipids-and-free-fatty-acids
#8
Lena Foseid, Hanne Devle, Yngve Stenstrøm, Carl Fredrik Naess-Andresen, Dag Ekeberg
A thorough analysis of the fatty acid profiles of stipe and blade from the kelp species Laminaria hyperborea is presented. Lipid extracts were fractionated into neutral lipids, free fatty acids, and polar lipids, prior to derivatization and GC-MS analysis. A total of 42 fatty acids were identified and quantified, including the n-3 fatty acids α-linolenic acid, stearidonic acid, and eicosapentaenoic acid. The fatty acid amounts are higher in blade than in stipe (7.42 mg/g dry weight and 2.57 mg/g dry weight, resp...
2017: Journal of Lipids
https://www.readbyqxmd.com/read/28492102/determinants-of-fluid-intelligence-in-healthy-aging-omega-3-polyunsaturated-fatty-acid-status-and-frontoparietal-cortex-structure
#9
Marta K Zamroziewicz, Erick J Paul, Chris E Zwilling, Aron K Barbey
INTRODUCTION: Accumulating evidence indicates that cognitive decline depends not only upon changes in brain health, but critically, also upon nutritional status. Decline in fluid intelligence, one of the most debilitating aspects of cognitive aging, has been linked to omega-3 polyunsaturated fatty acid (PUFA) status; however, it is not known whether this phenomenon results from specific omega-3 PUFAs acting on particular aspects of brain health. Therefore, this study aims to explore whether particular patterns of omega-3 PUFAs influence fluid intelligence by supporting specific neural structures...
May 11, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28411302/common-and-species-specific-effects-of-phosphate-on-marine-microalgae-fatty-acids-shape-their-function-in-phytoplankton-trophic-ecology
#10
José Pedro Cañavate, Isabel Armada, Ismael Hachero-Cruzado
The use of fatty acids (FA) to infer structure of phytoplankton assemblages and as indicators of microalgae nutritional value is acquiring relevance in modern phytoplankton ecology and new advances concerning factors influencing FA variability among microalgae are demanded. In this regard, the relationship between phosphorus and FA remains particularly little studied in marine phytoplankton. In the present study, we focus on phosphate effects on FA from a diversified set of marine microalgae and provide new insights into the applicability of FA in phytoplankton trophic ecology...
April 14, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28287415/dietary-buglossoides-arvensis-oil-increases-circulating-n-3-polyunsaturated-fatty-acids-in-a-dose-dependent-manner-and-enhances-lipopolysaccharide-stimulated-whole-blood-interleukin-10-a-randomized-placebo-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Natalie Lefort, Rémi LeBlanc, Marc E Surette
Buglossoides arvensis (Ahiflower) oil is a dietary oil rich in stearidonic acid (20% SDA; 18:4 n-3). The present randomized, double blind, placebo-controlled clinical trial investigated the effects of three Ahiflower oil dosages on omega-3 polyunsaturated fatty acid (PUFA) content of plasma and mononuclear cells (MCs) and of the highest Ahiflower dosage on stimulated cytokine production in blood. Healthy subjects (n = 88) consumed 9.7 mL per day for 28 days of 100% high oleic sunflower oil (HOSO); 30% Ahiflower oil (Ahi) + 70% HOSO; 60% Ahi + 40% HOSO; and 100% Ahi...
March 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28094560/systemic-metabolite-changes-in-wild-type-c57bl-6-mice-fed-black-raspberries
#12
Pan Pan, Chad W Skaer, Hsin-Tzu Wang, Michael A Kreiser, Steven M Stirdivant, Kiyoko Oshima, Yi-Wen Huang, Matthew R Young, Li-Shu Wang
INTRODUCTION: Freeze-dried black raspberries (BRBs) elicit chemopreventive effects against colorectal cancer in humans and in rodents. The objective of this study was to investigate potential BRB-caused metabolite changes using wild-type (WT) C57BL/6 mice. METHODS AND RESULTS: WT mice were fed either control diet or control diet supplemented with 5% BRBs for 8 wk. A nontargeted metabolomic analysis was conducted on colonic mucosa, liver, and fecal specimens collected from both diet groups...
February 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27981494/fall-composition-of-storage-lipids-is-associated-with-the-overwintering-strategy-of-daphnia
#13
Heather L Mariash, Mathieu Cusson, Milla Rautio
Diapause, which occurs through the production of dormant eggs, is a strategy used by some zooplankton to avoid winter months of persistent low temperatures and low food availability. However, reports of active zooplankton under the ice indicate that other strategies also exist. This study was aimed at evaluating whether the composition of storage lipids in the fall differs between diapausing and active overwintering Daphnia. We assessed the quantity of storage lipids and fatty acid (FA) composition of Daphnia species, along with FA content of seston, in six boreal, alpine and subarctic lakes at the onset of winter, and evaluated the association between storage lipids and Daphnia overwintering strategy...
January 2017: Lipids
https://www.readbyqxmd.com/read/27786470/molecular-characterization-and-anti-inflammatory-activity-of-galactosylglycerides-and-galactosylceramides-from-the-microalga-isochrysis-galbana
#14
Carolina de Los Reyes, María J Ortega, Azahara Rodríguez-Luna, Elena Talero, Virginia Motilva, Eva Zubía
Isochrysis galbana is a marine microalga rich in PUFAs that is widely used as feed in aquaculture and more recently investigated for its potential in food applications and as source of bioactive compounds. In this study, the biomass obtained from cultures of I. galbana has been investigated to determine its content in glycosylglycerides and glycosylceramides. By using NMR, UPLC-MS/MS, and fatty acid profiles, the structures of ten monogalactosyldiacylglycerols (MGDGs 1-10) and nine digalactosyldiacylglycerols (DGDGs 11-19) have been established...
November 23, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27719932/sardinian-boraginaceae-are-new-potential-sources-of-gamma-linolenic-acid
#15
José Luis Guil-Guerrero, Francisco Gómez-Mercado, Rebeca Pilar Ramos-Bueno, María José González-Fernández, Miguel Urrestarazu, Miguel Ángel Rincón-Cervera
The aim of this work was to establish the richness in γ-linolenic acid (GLA, 18:3n6) and stearidonic acid (SDA, 18:4n3) of several Sardinian Boraginaceae species. To this end, seeds of selected species were collected from their natural habitats and analysed. The highest GLA contents were found in the seed oils of two endemic Borago taxa, i.e. B. morisiana (24.4 and 24.6% GLA of total fatty acids for samples from San Pietro Island and Sardinia Island, respectively), and 22.9% GLA for B. pygmaea. Both Borago species contained more GLA than B...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27673473/effect-of-green-and-red-light-in-lipid-accumulation-and-transcriptional-profile-of-genes-implicated-in-lipid-biosynthesis-in-chlamydomonas-reinhardtii
#16
Daniel Eugenio Gaytán-Luna, Ana Erika Ochoa-Alfaro, Alejandro Rocha-Uribe, Ana Silvia Pérez-Martínez, Ángel Gabriel Alpuche-Solís, Ruth Elena Soria-Guerra
Microalgae have the potential to accumulate triacylglycerols under different light spectra. In this work, Chlamydomonas reinhardtii was grown under white (400-700 nm), red (650 nm), and green (550 nm) lights. According to our results, red light (650 nm) has a positive effect in the microalgae growth and chlorophyll concentration. About the lipid content, the control culture (white light-illuminated) reached a 4.4% of dry cell weight (dcw), whereas the culture grown at 550 nm showed an increase of 1.35-fold in the lipids accumulation (5...
November 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27496755/metabolism-and-functional-effects-of-plant-derived-omega-3-fatty-acids-in-humans
#17
REVIEW
Ella J Baker, Elizabeth A Miles, Graham C Burdge, Parveen Yaqoob, Philip C Calder
Alpha-linolenic acid (ALA) is an essential fatty acid and the substrate for the synthesis of longer-chain, more unsaturated ω-3 fatty acids, eicosapentaenoic acid (EPA), docosapentaenoic acid and docosahexaenoic acid (DHA). EPA and DHA are associated with human health benefits. The primary source of EPA and DHA is seafood. There is a need for sustainable sources of biologically active ω-3 fatty acids. Certain plants contain high concentrations of ALA and stearidonic acid (SDA). Here we review the literature on the metabolism of ALA and SDA in humans, the impact of increased ALA and SDA consumption on concentrations of EPA and DHA in blood and cell lipid pools, and the extent to which ALA and SDA might have health benefits...
October 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27496594/towards-the-development-of-a-sustainable-soya-bean-based-feedstock-for-aquaculture
#18
Hyunwoo Park, Steven Weier, Fareha Razvi, Pamela A Peña, Neil A Sims, Jennica Lowell, Cory Hungate, Karma Kissinger, Gavin Key, Paul Fraser, Johnathan A Napier, Edgar B Cahoon, Tom E Clemente
Soya bean (Glycine max (L.) Merr.) is sought after for both its oil and protein components. Genetic approaches to add value to either component are ongoing efforts in soya bean breeding and molecular biology programmes. The former is the primary vegetable oil consumed in the world. Hence, its primary usage is in direct human consumption. As a means to increase its utility in feed applications, thereby expanding the market of soya bean coproducts, we investigated the simultaneous displacement of marine ingredients in aquafeeds with soya bean-based protein and a high Omega-3 fatty acid soya bean oil, enriched with alpha-linolenic and stearidonic acids, in both steelhead trout (Oncorhynchus mykiss) and Kampachi (Seriola rivoliana)...
February 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27461155/chemotaxonomic-screening-of-seed-oils-from-the-family-saxifragaceae-and-comparison-with-data-on-seed-oils-from-grossulariaceae-obtained-from-literature
#19
COMPARATIVE STUDY
Bertrand Matthäus, Choijiljav Otgonbayar
Seeds of 25 members of the family Saxifragaceae, 1 × Astilbe, 1 × Darmera, 1 × Leptarrhena, 1 × Tellima, 3 × Mitella, and 18 × Saxifraga were investigated regarding oil content, as well as composition and content of fatty acids and vitamin E active compounds. The results were compared with results obtained from literature for members of the genus Ribes belonging to the closely related family Grossulariaceae to find chemometric differences between the different genera and between members of the family Saxifragaceae and Grossulariaceae, respectively...
November 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27425758/enantiomeric-separation-of-triacylglycerols-containing-polyunsaturated-fatty-acids-with-18-carbon-atoms
#20
Tomáš Řezanka, Linda Nedbalová, Karel Sigler
Regioisomers and enantiomers of triacylglycerols (TAGs) containing any combination of stearidonic (18:4n-3) and octadecapentaenoic (18:5n-3) acids were prepared by organic synthesis. Gradient polar organic liquid chromatography/high resolution atmospheric pressure chemical ionization-tandem mass spectrometry (NARP-LC/HRMS(2)-APCI) and chiral liquid chromatography were used for the separation and identification of molecular species of these TAGs. Further, NARP-LC and chiral LC were used to separate natural mixtures of TAGs obtained from the haptophyte alga Coccolithophora sp...
October 7, 2016: Journal of Chromatography. A
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