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Stearidonic acid

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https://www.readbyqxmd.com/read/29537611/structural-determination-and-occurrence-in-ahiflower-oil-of-stearidonic-acid-trans-fatty-acids
#1
Pierluigi Delmonte, Andrea Milani, Shivani Bhangley
Several marine oils and seed oils on the market contain relevant quantities of stearidonic acid (18:4n-3, SDA). The formation of 18:4n-3 trans fatty acids (tFA) during the refining of these oils necessitates the development of a method for their quantification. In this study, 18:4n-3 was isolated from Ahiflower and isomerized to obtain its 16 geometric isomers. The geometric isomers of 18:4n-3 were isolated by silver ion HPLC (Ag+ -HPLC) and characterized by partial reduction with hydrazine followed by gas chromatography analysis...
March 14, 2018: Lipids
https://www.readbyqxmd.com/read/29495107/enhancing-total-lipid-and-stearidonic-acid-yields-in-buglossoides-arvensis-through-pgpr-inoculation
#2
A Novinscak, M Filion
AIM: This study was performed to identify bacterial isolates capable of enhancing total lipid and stearidonic acid (SDA) yields in Buglossoides arvensis. METHODS AND RESULTS: Pot experiments were conducted to screen the effects of 40 bacterial isolates on different B. arvensis growth parameters. Five isolates increased total lipid and SDA yields by at least 20%. These isolates were tested in a second pot experiment and in field trials. The second pot experiment confirmed that all isolates significantly increased total lipid and SDA yields over controls...
March 1, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29492405/biofortified-crops-generated-by-breeding-agronomy-and-transgenic-approaches-are-improving-lives-of-millions-of-people-around-the-world
#3
REVIEW
Monika Garg, Natasha Sharma, Saloni Sharma, Payal Kapoor, Aman Kumar, Venkatesh Chunduri, Priya Arora
Biofortification is an upcoming, promising, cost-effective, and sustainable technique of delivering micronutrients to a population that has limited access to diverse diets and other micronutrient interventions. Unfortunately, major food crops are poor sources of micronutrients required for normal human growth. The manuscript deals in all aspects of crop biofortification which includes-breeding, agronomy, and genetic modification. It tries to summarize all the biofortification research that has been conducted on different crops...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29478542/enhancing-stability-of-echium-seed-oil-and-beta-sitosterol-by-their-coencapsulation-by-complex-coacervation-using-different-combinations-of-wall-materials-and-crosslinkers
#4
Talita A Comunian, Marina Nogueira, Bianca Scolaro, Marcelo Thomazini, Roselayne Ferro-Furtado, Inar Alves de Castro, Carmen S Favaro-Trindade
Intake of omega-3 fatty acids and phytosterols aids in the reduction of cholesterol and serum triglycerides. However, both fatty acids and phytosterols are susceptible to oxidation. This work coencapsulated echium oil (source of stearidonic and alpha-linolenic fatty acids) and beta-sitosterol (phytosterol) by complex coacervation using different combinations of wall materials, and sinapic acid (SA) and transglutaminase as crosslinkers. High encapsulation yields were obtained (29-93% for SA; 68-100% for the mixture of oil and phytosterols) and retention of 49-99% and 16% for encapsulated and free SA, at 30 days-storage...
June 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29350557/omega-3-polyunsaturated-fatty-acids-and-their-health-benefits
#5
Fereidoon Shahidi, Priyatharini Ambigaipalan
Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18:3 ω-3), stearidonic acid (SDA; 18:4 ω-3), eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3). In the past few decades, many epidemiological studies have been conducted on the myriad health benefits of omega-3 PUFAs. In this review, we summarized the structural features, properties, dietary sources, metabolism, and bioavailability of omega-3 PUFAs and their effects on cardiovascular disease, diabetes, cancer, Alzheimer's disease, dementia, depression, visual and neurological development, and maternal and child health...
March 25, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29288354/functional-characterization-and-substrate-specificity-analysis-of-%C3%AE-6-desaturase-from-marine-microalga-isochrysis-sp
#6
S Thiyagarajan, M Arumugam, N Senthil, S Vellaikumar, S Kathiresan
OBJECTIVES: To express a Δ6-desaturase gene and produce gamma-linolenic acid (GLA) and stearidonic acid (SDA) in prokaryotic expression system (Escherichia coli), and analyze its substrate specificity in the omega-3 fatty acid biosynthetic pathway. RESULTS: Full-length ORF (1448 bp) of Δ6Des-Iso was isolated from Isochrysis sp. and characterized using multiple sequence alignment, phylogenetic analysis, transmembrane domain, and protein tertiary structure. Δ6Des-Iso is a front-end desaturase consisting of three conserved histidine domains and a cytochrome b5 domain...
March 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29278384/marine-cryptophytes-are-great-sources-of-epa-and-dha
#7
Elina Peltomaa, Matthew D Johnson, Sami J Taipale
Microalgae have the ability to synthetize many compounds, some of which have been recognized as a source of functional ingredients for nutraceuticals with positive health effects. One well-known example is the long-chain polyunsaturated fatty acids (PUFAs), which are essential for human nutrition. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the two most important long-chain omega-3 (ω-3) PUFAs involved in human physiology, and both industries are almost exclusively based on microalgae. In addition, algae produce phytosterols that reduce serum cholesterol...
December 26, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29054673/fluvial-biofilms-exposed-to-desiccation-and-pharmaceutical-pollution-new-insights-using-metabolomics
#8
Albert Serra-Compte, Natàlia Corcoll, Belinda Huerta, Sara Rodríguez-Mozaz, Sergi Sabater, Damià Barceló, Diana Álvarez-Muñoz
In many arid and semi-arid systems, biological communities in river ecosystems are submitted to flow interruption and desiccation, as well as to the impact of urban wastewaters. In this work, we studied (using a LC-LTQ-Orbitrap) the metabolomic response of biofilm communities exposed to both hydrological and chemical stressors. Fluvial biofilms were exposed to a mixture of 9 pharmaceuticals at a total concentration of 5000ng/L (mimicking concentrations and compounds found in polluted aquatic environments) and/or to seven days of desiccation, under laboratory conditions...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29048366/lipase-catalyzed-transesterification-of-egg-yolk-phophatidylcholine-with-concentrate-of-n-3-polyunsaturated-fatty-acids-from-cod-liver-oil
#9
Anna Chojnacka, Witold Gładkowski, Aleksandra Grudniewska
Phospholipids containing PUFAs are important vehicles for their delivering to the targeted tissues. In our research project we established enzymatic methods for the enrichment of natural egg-yolk PC with n-3 PUFAs. Instead of synthetic PUFA ethyl esters, the new strategy was developed using polyunsaturated fatty acids enriched fraction (PUFA-EF) from cod liver oil as the natural acyl donors. PUFA-EF was produced by urea-complexation and contained 86.9% PUFA including 8.5% stearidonic acid (SDA; 18:4(n-3)), 26...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28946872/suppression-of-adipocyte-differentiation-and-lipid-accumulation-by-stearidonic-acid-sda-in-3t3-l1-cells
#10
Yueru Li, Yinghui Rong, Lisui Bao, Ben Nie, Guang Ren, Chen Zheng, Rajesh Amin, Robert D Arnold, Ramesh B Jeganathan, Kevin W Huggins
BACKGROUND: Increased consumption of omega-3 (ω-3) fatty acids found in cold-water fish and fish oil has been reported to protect against obesity. A potential mechanism may be through reduction in adipocyte differentiation. Stearidonic acid (SDA), a plant-based ω-3 fatty acid, has been targeted as a potential surrogate for fish-based fatty acids; however, its role in adipocyte differentiation is unknown. This study was designed to evaluate the effects of SDA on adipocyte differentiation in 3T3-L1 cells...
September 25, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28874672/unravelling-a-stearidonic-acid-rich-triacylglycerol-biosynthetic-pathway-in-the-developing-seeds-of-buglossoides-arvensis-a-transcriptomic-landscape
#11
R V Sreedhar, P Prasad, L Prasanna Anjaneya Reddy, Ram Rajasekharan, Malathi Srinivasan
Buglossoides arvensis is an emerging oilseed crop that is rich in stearidonic acid (SDA) and has several potential applications in human health and nutrition. The molecular basis of SDA biosynthesis in this plant remains unknown due to lack of genomic information. To unravel key genes involved in SDA-rich triacylglycerol (TAG) biosynthesis, we performed transcriptome sequencing of pooled mRNA from five different developmental stages of B. arvensis seeds using Illumina NextSeq platform. De novo transcriptome assembly generated 102,888 clustered transcripts from 39...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762000/production-of-%C3%AF-3-fatty-acids-in-marine-cyanobacterium-synechococcus-sp-strain-nkbg-15041c-via-genetic-engineering
#12
Tomoko Yoshino, Natsumi Kakunaka, Yue Liang, Yasuhito Ito, Yoshiaki Maeda, Tatsuhiro Nomaguchi, Tadashi Matsunaga, Tsuyoshi Tanaka
Omega-3 fatty acids (ω3 FAs) have attracted attention because they have various health benefits for humans. Fish oils are currently major sources of ω3 FAs, but a sustainable supply of ω3 FAs based on fish oils is problematic because of the increasing demand. In this study, the production potential of a genetically engineered marine cyanobacterium, Synechococcus sp. strain NKBG 15041c, was examined as an alternative source of ω3 FAs. A change in fatty acid composition of this cyanobacterium was successfully induced by the expression of a heterologous Δ6-desaturase, and the transformants synthesized stearidonic acid, which the wild type cannot produce...
September 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28756366/structure-of-unsaturated-fatty-acids-in-2d-system
#13
J L Fidalgo Rodríguez, P Dynarowicz-Latka, J Miñones Conde
The behaviour of Langmuir monolayers corresponding to unsaturated fatty acids belonging to the omega-9 (oleic acid), omega-3 (α-linolenic and stearidonic acids) and omega-6 (linoleic, γ-linolenic and eicosadienoic acids) series was studied in order to get insight into the influence of various factors (such as subphase temperature, length, degree of unsaturation and position of the double bonds in the aliphatic chains) on the molecular conformation of these fatty acids spread at the A/W interface. The obtained results derived from the surface pressure - area isotherms, compressibility modulus and monolayer thickness prove that the lift-off and the limiting areas of investigated films increase both with the number of double bonds and length of the hydrocarbon chain...
October 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28744771/anti-inflammatory-effects-of-stearidonic-acid-mediated-by-suppression-of-nf-%C3%AE%C2%BAb-and-map-kinase-pathways-in-macrophages
#14
Jeehye Sung, Heemang Jeon, In-Hwan Kim, Heon Sang Jeong, Junsoo Lee
Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264...
July 25, 2017: Lipids
https://www.readbyqxmd.com/read/28713595/fatty-acid-profiles-of-stipe-and-blade-from-the-norwegian-brown-macroalgae-laminaria-hyperborea-with-special-reference-to-acyl-glycerides-polar-lipids-and-free-fatty-acids
#15
Lena Foseid, Hanne Devle, Yngve Stenstrøm, Carl Fredrik Naess-Andresen, Dag Ekeberg
A thorough analysis of the fatty acid profiles of stipe and blade from the kelp species Laminaria hyperborea is presented. Lipid extracts were fractionated into neutral lipids, free fatty acids, and polar lipids, prior to derivatization and GC-MS analysis. A total of 42 fatty acids were identified and quantified, including the n-3 fatty acids α-linolenic acid, stearidonic acid, and eicosapentaenoic acid. The fatty acid amounts are higher in blade than in stipe (7.42 mg/g dry weight and 2.57 mg/g dry weight, resp...
2017: Journal of Lipids
https://www.readbyqxmd.com/read/28492102/determinants-of-fluid-intelligence-in-healthy-aging-omega-3-polyunsaturated-fatty-acid-status-and-frontoparietal-cortex-structure
#16
Marta K Zamroziewicz, Erick J Paul, Chris E Zwilling, Aron K Barbey
INTRODUCTION: Accumulating evidence indicates that cognitive decline depends not only upon changes in brain health, but critically, also upon nutritional status. Decline in fluid intelligence, one of the most debilitating aspects of cognitive aging, has been linked to omega-3 polyunsaturated fatty acid (PUFA) status; however, it is not known whether this phenomenon results from specific omega-3 PUFAs acting on particular aspects of brain health. Therefore, this study aims to explore whether particular patterns of omega-3 PUFAs influence fluid intelligence by supporting specific neural structures...
May 11, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28411302/common-and-species-specific-effects-of-phosphate-on-marine-microalgae-fatty-acids-shape-their-function-in-phytoplankton-trophic-ecology
#17
José Pedro Cañavate, Isabel Armada, Ismael Hachero-Cruzado
The use of fatty acids (FA) to infer structure of phytoplankton assemblages and as indicators of microalgae nutritional value is acquiring relevance in modern phytoplankton ecology and new advances concerning factors influencing FA variability among microalgae are demanded. In this regard, the relationship between phosphorus and FA remains particularly little studied in marine phytoplankton. In the present study, we focus on phosphate effects on FA from a diversified set of marine microalgae and provide new insights into the applicability of FA in phytoplankton trophic ecology...
October 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28287415/dietary-buglossoides-arvensis-oil-increases-circulating-n-3-polyunsaturated-fatty-acids-in-a-dose-dependent-manner-and-enhances-lipopolysaccharide-stimulated-whole-blood-interleukin-10-a-randomized-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Natalie Lefort, Rémi LeBlanc, Marc E Surette
Buglossoides arvensis (Ahiflower) oil is a dietary oil rich in stearidonic acid (20% SDA; 18:4 n-3). The present randomized, double blind, placebo-controlled clinical trial investigated the effects of three Ahiflower oil dosages on omega-3 polyunsaturated fatty acid (PUFA) content of plasma and mononuclear cells (MCs) and of the highest Ahiflower dosage on stimulated cytokine production in blood. Healthy subjects (n = 88) consumed 9.7 mL per day for 28 days of 100% high oleic sunflower oil (HOSO); 30% Ahiflower oil (Ahi) + 70% HOSO; 60% Ahi + 40% HOSO; and 100% Ahi...
March 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28094560/systemic-metabolite-changes-in-wild-type-c57bl-6-mice-fed-black-raspberries
#19
Pan Pan, Chad W Skaer, Hsin-Tzu Wang, Michael A Kreiser, Steven M Stirdivant, Kiyoko Oshima, Yi-Wen Huang, Matthew R Young, Li-Shu Wang
INTRODUCTION: Freeze-dried black raspberries (BRBs) elicit chemopreventive effects against colorectal cancer in humans and in rodents. The objective of this study was to investigate potential BRB-caused metabolite changes using wild-type (WT) C57BL/6 mice. METHODS AND RESULTS: WT mice were fed either control diet or control diet supplemented with 5% BRBs for 8 wk. A nontargeted metabolomic analysis was conducted on colonic mucosa, liver, and fecal specimens collected from both diet groups...
February 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27981494/fall-composition-of-storage-lipids-is-associated-with-the-overwintering-strategy-of-daphnia
#20
Heather L Mariash, Mathieu Cusson, Milla Rautio
Diapause, which occurs through the production of dormant eggs, is a strategy used by some zooplankton to avoid winter months of persistent low temperatures and low food availability. However, reports of active zooplankton under the ice indicate that other strategies also exist. This study was aimed at evaluating whether the composition of storage lipids in the fall differs between diapausing and active overwintering Daphnia. We assessed the quantity of storage lipids and fatty acid (FA) composition of Daphnia species, along with FA content of seston, in six boreal, alpine and subarctic lakes at the onset of winter, and evaluated the association between storage lipids and Daphnia overwintering strategy...
January 2017: Lipids
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