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https://www.readbyqxmd.com/read/29676667/evaluating-the-clinical-value-of-the-hypoxia-burden-index-in-patients-with-obstructive-sleep-apnea
#1
Fengwei Chen, Kun Chen, Cheng Zhang, Xue Chen, Junjun Huang, Peng Jia, Jing Ma, Jue Zhang, Jing Fang, Guangfa Wang
PURPOSE: We aimed to develop a novel index, the hypoxia burden index (HBI), that reflects the degree and duration of oxygen desaturation, and to determine whether this index is better than the apnea hypopnea-index (AHI) for evaluating obstructive sleep apnea (OSA) and cardiovascular diseases morbidities. METHODS: We retrospectively analyzed 459 adult subjects who underwent overnight polysomnography (PSG) in this study. The HBI was calculated by dividing the total desaturation area of SpO2 below 90% by the TST measured in seconds...
April 20, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29664672/primary-care-physicians-can-comprehensively-manage-sleep-apnea-patients-a-non-inferiority-randomized-controlled-trial
#2
M Ángeles Sánchez-Quiroga, Jaime Corral, Francisco J Gómez-de-Terreros, Carmen Carmona-Bernal, M Isabel Asensio-Cruz, Marta Cabello, M Ángeles Martínez-Martínez, Carlos J Egea, Estrella Ordax, Ferran Barbe, Javier Barca, Juan F Masa
RATIONALE: General practitioners play a passive role in obstructive sleep apnea (OSA) management. Simplification of the diagnosis and use of a semi-automatic algorithm for treatment can facilitate the integration of general practitioners, which has cost advantages. OBJECTIVE: To determine differences in effectiveness between primary healthcare area (PHA) and in-hospital specialized management protocols during six months of follow-up. METHOD: A multicenter, non-inferiority, randomized, controlled trial with two open parallel arms and a cost-effectiveness analysis was performed in six tertiary hospitals in Spain...
April 17, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29664048/effect-of-rapid-eye-movement-sleep-behavior-disorder-on-obstructive-sleep-apnea-severity-and-cognition-of-parkinson-s-disease-patients
#3
Jun-Ying Huang, Jin-Ru Zhang, Yun Shen, Hui-Jun Zhang, Yu-Lan Cao, Cheng-Jie Mao, Ya-Ping Yang, Jing Chen, Chun-Feng Liu, Jie Li
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG)...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29656058/engaging-vulnerable-populations-in-parent-led-support-groups-testing-a-recruitment-strategy
#4
Louis D Brown, Adeniyi A Adeboye, Rafeek A Yusuf, Pooja Chaudhary
Despite the proven benefits of parenting interventions, parent engagement in such interventions remains low and is particularly challenging among vulnerable populations. This theoretically grounded study tested the effectiveness of a recruitment strategy - a simulated parent-led support group (PSG) - to increase intentions to attend a PSG in a predominantly low income, minority sample. The study also examined sociodemographic characteristics that may influence the effectiveness of the recruitment strategy and engagement in PSGs...
April 5, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29649379/decrease-of-plasma-soluble-pro-renin-receptor-by-bariatric-surgery-in-patients-with-obstructive-sleep-apnea-and-morbid-obesity
#5
Tsuguo Nishijima, Koji Ohba, Shigeaki Baba, Testuya Kizawa, Keisuke Hosokawa, Fumiyo Endo, Yoshihiro Yamashiro, Akira Suwabe, Akira Sasaki, Kazuhiro Takahashi, Shigeru Sakurai
BACKGROUND: Plasma concentrations of soluble (pro)renin receptor [s(P)RR], which are elevated in patients with obstructive sleep apnea (OSA), have not been studied in morbid obesity. The aim of this study is to clarify effects of bariatric surgery on plasma s(P)RR concentrations and identify associated factors for their changes in OSA patients with morbid obesity. METHODS: Twenty-three patients with OSA complicated by morbid obesity (10 men and 13 women; body mass index, 40...
March 20, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29648642/a-novel-forehead-temperature-regulating-device-for-insomnia-a-randomized-clinical-trial
#6
Thomas Roth, David Mayleben, Neil Feldman, Alan Lankford, Timothy Grant, Eric Nofzinger
Study Objectives: Insomnia is one of the most common disorders in the general population. Hypnotic medications are efficacious, but their use is limited by adverse events (AEs). This study evaluated the safety and efficacy of a novel forehead temperature-regulating device that delivers frontal cerebral thermal therapy (maintained at 14-16°C, equivalent to 57-61°F) for the treatment of insomnia. Methods: This was a prospective, randomized controlled trial involving two nights of therapy in 106 adults diagnosed with insomnia...
April 10, 2018: Sleep
https://www.readbyqxmd.com/read/29645353/discovering-genes-responsible-for-silk-synthesis-in-bombyx-mori-by-piggybac-based-random-insertional-mutagenesis
#7
Xing-Bao Feng, Zi-Wen Zheng, Xian Zhang, Jun Gu, Qi-Li Feng, Li-Hua Huang
Silkworm mutants are valuable resources for both transgenic breeding and gene discovery. PiggyBac-based random insertional mutagenesis has been widely used in gene functional studies. In order to discover genes involved in silk synthesis, a piggyBac-based random insertional library was constructed using Bombyx mori, and the mutants with abnormal cocoon were particularly screened. By this mean, a "thin cocoon" mutant was identified. This mutant revealed thinner cocoon shell and shorter posterior silk gland (PSG) comparing with the wild type...
April 12, 2018: Insect Science
https://www.readbyqxmd.com/read/29626602/protective-properties-of-combined-fungal-polysaccharides-from-cordyceps-sinensis-and-ganoderma-atrum-on-colon-immune-dysfunction
#8
Song-Tao Fan, Shao-Ping Nie, Xiao-Jun Huang, Sunan Wang, Jie-Lun Hu, Jun-Hua Xie, Qi-Xing Nie, Ming-Yong Xie
In vivo an ecological network of polysaccharides utilization by gut microbiota is not only an intense competition but also an impressive cooperation pattern. The present study evaluated the in vivo protective effect of combined fungal polysaccharides (CFP) from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction, induced by 150 mg/kg cyclophosphamide (CP). The results showed that C. sinensis polysaccharides (CSP) significantly promoted microbial-derived butyrate to improve histone h3 acetylation mediating regulatory T (Treg) cell specific Foxp3, as well as significantly restored CP-induced elevation of interleukin (IL)-17 and IL-21...
April 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29624601/sleep-apnea-detection-by-a-cardiac-resynchronization-device-integrated-thoracic-impedance-sensor-a-validation-study-against-the-gold-standard-polysomnography
#9
Fabian Barbieri, Wolfgang Dichtl, Anna Heidbreder, Elisabeth Brandauer, Ambra Stefani, Agne Adukauskaite, Thomas Senoner, Wilfried Schgör, Florian Hintringer, Birgit Högl
BACKGROUND: Sleep disordered breathing is a common but often undiagnosed comorbidity in heart failure patients. Cardiac implantable electronic devices used for cardiac resynchronization therapy (CRT) may detect sleep apnea by use of a transthoracic impedance sensor. Validation of the AP scan® algorithm (Boston Scientific®) was performed by using the diagnostic gold standard polysomnography (PSG). METHODS: Forty-one patients with impaired left ventricular ejection fraction, frequent right ventricular pacing due to atrioventricular block and heart failure symptoms despite optimal medical therapy underwent upgrading to biventricular pacing...
2018: PloS One
https://www.readbyqxmd.com/read/29624167/proteasome-storage-granules-protect-proteasomes-from-autophagic-degradation-upon-carbon-starvation
#10
Richard Scott Marshall, Richard David Vierstra
26S proteasome abundance is tightly regulated at multiple levels, including the elimination of excess or inactive particles by autophagy. In yeast, this proteaphagy occurs upon nitrogen starvation but not carbon starvation, which instead stimulates the rapid sequestration of proteasomes into cytoplasmic puncta termed proteasome storage granules (PSGs). Here, we show that PSGs help protect proteasomes from autophagic degradation. Both the core protease and regulatory particle sub-complexes are sequestered separately into PSGs via pathways dependent on the accessory proteins Blm10 and Spg5, respectively...
April 6, 2018: ELife
https://www.readbyqxmd.com/read/29623407/adding-sleep-restriction-to-the-equation-impact-on-wildland-firefighters-work-performance-and-physiology-in-hot-conditions
#11
Grace E Vincent, Sally Ferguson, Brianna Larsen, Nicola D Ridgers, Rod Snow, Brad Aisbett
PURPOSE: To examine the effects of sleep restriction on firefighters' physical task performance, physical activity, and physiological and perceived exertion during simulated hot wildfire conditions. METHODS: 31 firefighters were randomly allocated to either the hot (n = 18, HOT; 33 °C, 8-h sleep opportunity) or hot and sleep restricted (n = 13, HOT + SR; 33 °C, 4-h sleep opportunity) condition. Intermittent, self-paced work circuits of six firefighting tasks were performed for 3 days...
April 6, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29620019/a-comparison-of-probabilistic-classifiers-for-sleep-stage-classification
#12
Pedro Fonseca, Niek den Teuling, Xi Long, Ronald M Aarts
To compare conditional random fields (CRF), hidden Markov models (HMMs) and Bayesian linear discriminants (LDs) for cardiorespiratory sleep stage classification on a five-class sleep staging task (Wake/N1/N2/N3/REM), to explore the benefit of incorporating time information in the classification and to evaluate the feasibility of sleep staging on obstructive sleep apnea (OSA) patients.
 Approach: The classifiers with and without time information were evaluated with 10-fold cross-validation on five-, four- (Wake/N1+N2/N3/REM) and three-class (Wake/NREM/REM) classification tasks using a data set comprising 443 night-time polysomnography (PSG) recordings of 231 participants (180 healthy participants, 100 of which with a 'regular' sleep architecture, and 51 participants previously diagnosed with OSA)...
April 5, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29619152/comparison-of-berlin-questionnaire-stop-bang-and-epworth-sleepiness-scale-for-diagnosing-obstructive-sleep-apnea-in-persian-patients
#13
Babak Amra, Maedeh Javani, Forogh Soltaninejad, Thomas Penzel, Ingo Fietze, Christoph Schoebel, Ziba Farajzadegan
Background: Obstructive sleep apnea (OSA) is a common disorder characterized by snoring, daytime sleepiness, fatigue, and repeated termination of airflow (apnea). Standard polysomnography (PSG) is diagnostic gold standard for OSA. PSG is expensive and not available everywhere. To identify the best OSA questionnaire for screening in Persian population, we compared Berlin, STOP-BANG, and Epworth Sleepiness Scale (ESS). Methods: In a cross-sectional study conducted on 400 adult patients suspected of OSA in Bamdad Respiratory Research Center, patients completed three questionnaires...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29609722/the-validity-of-a-new-consumer-targeted-wrist-device-in-sleep-measurement-an-overnight-comparison-against-polysomnography-in-children-and-adolescents
#14
Anu-Katriina Pesonen, Liisa Kuula
STUDY OBJECTIVES: The validity of consumer-targeted wrist-worn sleep measurement systems has been little studied in children and adolescents. We examined the validity of a new fitness tracker (PFT) manufactured by Polar Electro Oy and the previously validated Actiwatch 2 (AW2) from Philips Respironics against polysomnography (PSG) in children and adolescents. METHODS: Seventeen children (age 11.0 ± 0.8 years) and 17 adolescents (age 17.8 ± 1.8 years) wore the PFT and AW2 concurrently with an ambulatory PSG in their own home for 1 night...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29609704/role-of-positive-airway-pressure-therapy-for-obstructive-sleep-apnea-in-patients-with-stroke-a-randomized-controlled-trial
#15
Anupama Gupta, Garima Shukla, Mohammed Afsar, Shivani Poornima, Ravindra M Pandey, Vinay Goyal, Achal Srivastava, Deepti Vibha, Madhuri Behari
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is an independent risk factor for stroke. The objective of this study was to assess the effect of continuous positive airway pressure (CPAP) treatment on prevention of new vascular events among patients with stroke and OSA. METHODS: Consecutive conscious patients presenting with first imaging-confirmed arterial stroke were included, 6 weeks or more after ictus. All patients underwent clinical and polysomnography (PSG) testing...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29603712/a-retrospective-study-to-compare-the-use-of-the-mean-apnea-hypopnea-duration-and-the-apnea-hypopnea-index-with-blood-oxygenation-and-sleep-patterns-in-patients-with-obstructive-sleep-apnea-diagnosed-by-polysomnography
#16
Xiaojun Zhan, Fang Fang, Chan Wu, Jayant M Pinto, Yongxiang Wei
BACKGROUND The apnea-hypopnea index (AHI) and the mean apnea-hypopnea duration (MAD) are used to measure the severity of the symptoms of obstructive sleep apnea (OSA). The aim of this study was to compare the use of the MAD with the AHI as indicators of clinical and demographic parameters, blood oxygenation, and sleep parameters in patients diagnosed with OSA by polysomnography (PSG). MATERIAL AND METHODS A retrospective study included 511 patients with OSA diagnosed by PSG and who had the AHI and the MAD measured according to the guidelines from the American Academy of Sleep Medicine (AASM)...
March 31, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29602814/polysomnography-versus-limited-respiratory-monitoring-and-nurse-led-titration-to-optimise-non-invasive-ventilation-set-up-a-pilot-randomised-clinical-trial
#17
Maxime Patout, Gill Arbane, Antoine Cuvelier, Jean Francois Muir, Nicholas Hart, Patrick Brian Murphy
Polysomnography (PSG) is recommended for non-invasive ventilation (NIV) set-up in patients with chronic respiratory failure. In this pilot randomised clinical trial, we compared the physiological effectiveness of NIV set-up guided by PSG to limited respiratory monitoring (LRM) and nurse-led titration in patients with COPD-obstructive sleep apnoea (OSA) overlap. The principal outcome of interest was change in daytime arterial PaO2 of carbon dioxide (PaCO2 ) at 3 months. Fourteen patients with daytime PaCO2 >6 kPa and body mass index >30 kg/m2 were recruited...
March 30, 2018: Thorax
https://www.readbyqxmd.com/read/29580211/new-insight-into-the-mechanism-underlying-the-silk-gland-biological-process-by-knocking-out-fibroin-heavy-chain-in-the-silkworm
#18
Yong Cui, Yanan Zhu, Yongjian Lin, Lei Chen, Qili Feng, Wen Wang, Hui Xiang
BACKGROUND: Exploring whether and how mutation of silk protein contributes to subsequent re-allocation of nitrogen, and impacts on the timing of silk gland degradation, is important to understand silk gland biology. Rapid development and wide application of genome editing approach in the silkworm provide us an opportunity to address these issues. RESULTS: Using CRISPR/Cas9 system, we successfully performed genome editing of Bmfib-H. The loss-of-function mutations caused naked pupa and thin cocoon mutant phenotypes...
March 26, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29580072/bright-light-exposure-before-bedtime-impairs-response-inhibition-the-following-morning-a-non-randomized-crossover-study
#19
Jung-Ick Byun, Byeong Uk Lee, Yong Seo Koo, Jun-Sang Sunwoo, Jung-Ah Lim, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Manho Kim, Jong-Min Lim, Heon-Jeong Lee, Eunil Lee, Sang Kun Lee, Ki-Young Jung
INTRODUCTION: Bright light exposure in the late evening can affect cognitive function the following morning either by changing the biological clock and/or disturbing sleep, but the evidence for this effect is scarce, and the underlying mechanism remains unknown. In this study, we first aimed to evaluate the effect of bright light exposure before bedtime on frontal lobe activity the following morning using near-infrared spectroscopy (NIRS) during a Go/NoGo task. Second, we aimed to evaluate the effects of bright light exposure before bedtime on polysomnographic measures and on a frontal lobe function test the following morning...
March 26, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29569252/the-clinical-features-in-chinese-patients-with-prnp-d178n-mutation
#20
S Chen, S He, X-H Shi, X-J Shen, K-K Liang, J-H Zhao, B-C Yan, J-W Zhang
BACKGROUND AND PURPOSE: Fatal familial insomnia (FFI) is an autosomal dominant disease due to the D178N mutation of PRNP gene coupling with homozygous methionine (Met) at codon 129. It is generally considered that D178N mutation cases with 129 M/M homozygotes present as FFI, and 129 V/V as genetic CJD. However, the frequency of 129 Met alleles in Chinese population is much higher than that in Caucasians. This study aims to investigate the clinical features and genetic characteristics of Chinese D178N mutants in this genetic context...
March 22, 2018: Acta Neurologica Scandinavica
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