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https://www.readbyqxmd.com/read/28728615/success-of-tonsillectomy-for-obstructive-sleep-apnea-in-children-with-down-syndrome
#1
David G Ingram, Amanda G Ruiz, Dexiang Gao, Norman R Friedman
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS) and associated with significant morbidity. In the current study we examined polysomnographic outcomes of children with DS who underwent tonsillectomy. METHODS: A retrospective chart review of children with DS who underwent a tonsillectomy between 2009-2015 was performed. All children had either a concurrent adenoidectomy or had previously underwent an adenoidectomy. Children with preoperative and postoperative polysomnograms within 6 months of surgery were included in the analysis...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28709511/erectile-dysfunction-is-independently-associated-with-apnea-hypopnea-index-and-oxygen-desaturation-index-in-elderly-but-not-younger-community-dwelling-men
#2
Sean A Martin, Sarah L Appleton, Robert J Adams, Anne W Taylor, Andrew Vincent, Nicholas R Brook, Peter G Catcheside, Andrew Vakulin, R Douglas McEvoy, Nick A Antic, Gary A Wittert
OBJECTIVE(S): To examine the association between obstructive sleep apnea (OSA) and other sleep indices using polysomnography (PSG) data and erectile dysfunction (ED) in a representative cohort of men. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: Aged 40+ years (n=734; mean age [SD], 60.8 [10.9]). MEASUREMENTS: Men with no prior OSA diagnosis who underwent in-home PSG (Embletta X100; 2010-11) and ED assessment (Global Impotence Rating) were selected...
August 2017: Sleep Health
https://www.readbyqxmd.com/read/28707162/pulmonary-surfactant-associated-proteins-and-inflammatory-factors-in-obstructive-sleep-apnea
#3
Dongmei Lu, Ayiniger Abulimiti, Ting Wu, Ailigen Abudureyim, Nanfang Li
PURPOSE: Pulmonary surfactant (PS) plays roles in promoting the removal of the liquid, host defense, and immune regulation in the tracheal, bronchial, and alveoli epithelium. PS protein expression level can be regulated by oxygen levels and related free radicals. Obstructive sleep apnea (OSA) is featured with oxygen free radical production for damaging epithelial tissues and thus may affect PS production. The study was to explore the relationship between PS protein and OSA severity. METHODS: We collected serum and bronchoalveolar lavage fluid (BALF) samples from 35 OSA patients and 22 healthy subjects...
July 13, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28704743/sleep-abnormalities-in-juvenile-myoclonic-epilepsy-a-sleep-questionnaire-and-polysomnography-based-study
#4
Sujata Roshan, Vinod Puri, Neera Chaudhry, Anu Gupta, Sumit Kumar Rabi
PURPOSE: To evaluate the quality of sleep, its architecture and occurrence of epileptiform discharges with their distribution across various stages of sleep in patients of Juvenile myoclonic epilepsy (JME), both drug naïve as well as those already on treatment. METHODS: 99 patients of JME [36 drug naïve, 63 on antiepileptic drug(s) (AED)], and 30 healthy controls were recruited. Sleep quality and daytime sleepiness were evaluated with Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), respectively...
June 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28704370/insights-into-the-sand-fly-saliva-blood-feeding-and-immune-interactions-between-sand-flies-hosts-and-leishmania
#5
REVIEW
Tereza Lestinova, Iva Rohousova, Michal Sima, Camila I de Oliveira, Petr Volf
BACKGROUND: Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is composed of a diverse group of molecules with pharmacological and immunomodulatory properties. METHODS AND FINDINGS: In this review, we focus on 3 main aspects of sand fly salivary molecules: (1) structure and composition of salivary glands, including the properties of salivary molecules related to hemostasis and blood feeding, (2) immunomodulatory properties of salivary molecules and the diverse impacts of these molecules on leishmaniasis, ranging from disease exacerbation to vaccine development, and (3) use of salivary molecules for field applications, including monitoring host exposure to sand flies and the risk of Leishmania transmission...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28701993/no-impaired-glucose-tolerance-in-primary-insomnia-patients-with-normal-results-of-polysomnography
#6
Johanna Tschepp, Christoph J Lauer, Johanna Wilde-Frenz, Thomas Pollmächer
BACKGROUND: According to recent studies, sleep restriction and disruption both have a prominent negative influence on glucose metabolism. This could also be shown in sleep disorders, such as sleep apnea and the restless legs syndrome. However, similar studies regarding insomnia have not been that consistent, yet. Moreover, most previous studies did not include objective polysomnography (PSG) data. METHODS: Patients with primary insomnia (N = 17) and healthy controls (N = 15) were investigated using psychometric tests such as the Epworth Sleepiness Scale and the Pittsburgh sleep quality index (PSQI)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28694611/depression-as-a-manifestation-of-obstructive-sleep-apnea
#7
Sheikh Shoib, Javid A Malik, Shariq Masoodi
BACKGROUND: Obstructive sleep apnea (OSA) often results in a wide range of comorbid conditions, predominantly of the cardiovascular/respiratory, endocrine/metabolic, and neuropsychiatric symptoms. In view of the ambiguity of literature regarding the association between OSA and depression, we conducted this study to show any association between the two disorders. OBJECTIVE: The aim of the study was to see the association between OSA and depression and to study the prevalence of OSA in patients suffering from depression...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28691719/narcolepsy-type-1-and-hypersomnia-associated-with-a-psychiatric-disorder-show-different-slow-wave-activity-dynamics
#8
Ewa Walacik-Ufnal, Anna Justyna Piotrowska, Dorota Wołyńczyk-Gmaj, Piotr Januszko, Bartłomiej Gmaj, Marcin Ufnal, Marek Kabat, Marcin Wojnar
The aim of the study was to compare electrophysiological parameters of night sleep in narcolepsy type 1 and hypersomnia associated with a psychiatric disorder. Fortyfour patients: 15 with narcolepsy type 1, 14 with hypersomnia associated with a psychiatric disorder and 15 age- and sex-matched controls participated in the study. The study subjects filled in the Athens Insomnia Scale (AIS) and the Beck Depression Inventory (BDI). The severity of daytime sleepiness was quantified subjectively using the Epworth Sleepiness Scale (ESS) and the Stanford Sleepiness Scale (SSS), and objectively using the Multiple Sleep Latency Test (MSLT)...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28687968/associations-between-obstructive-sleep-apnea-severity-and-endoscopically-proven-gastroesophageal-reflux-disease
#9
Youlim Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Se Joong Kim
PURPOSE: Obstructive sleep apnea (OSA) is believed to be an important risk factor for gastroesophageal reflux disease (GERD). However, the association between OSA and GERD is not straightforward and has been incompletely characterized. The aim of this study was to assess the relationship between OSA and GERD by performing both polysomnography (PSG) and esophagogastroduodenoscopy (EGD). METHODS: The enrolled patients underwent both PSG and EGD from October 2003 to July 2015 at Seoul National University Bundang Hospital...
July 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28672085/structural-and-functional-ventilatory-impairment-in-infants-with-severe-bronchopulmonary-dysplasia
#10
Esther van Mastrigt, Ellaha Kakar, Pierluigi Ciet, Herman T den Dekker, Koen F Joosten, Patricia Kalkman, Renate Swarte, André A Kroon, Harm A W M Tiddens, Johan C de Jongste, Irwin Reiss, Liesbeth Duijts, Mariëlle W Pijnenburg
BACKGROUND: Bronchopulmonary dysplasia (BPD) is the most frequent serious complication in preterm infants. We aimed to describe lung structure and ventilatory function of preterm infants with severe BPD and explored the association between early postnatal growth and these outcomes. METHODS: We included preterm infants born ≤32 weeks gestational age (GA) with severe BPD. Lung structure was assessed on chest CT with the PRAGMA-BPD scoring system and ventilatory function by polysomnography (PSG) at 6 months corrected age...
July 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28669116/validation-of-apnealink%C3%A2-plus-for-the-diagnosis-of-sleep-apnea
#11
Jae Hoon Cho, Hyun Jun Kim
PURPOSE: The aim of this study is to evaluate the validation of ApneaLink™ Plus (ALP) based on a large number of subjects in a prospective design. METHOD: We recommended enrolling of 200 consecutive patients who had been referred because of habitual snoring or witnessed apnea during sleep. If consent was obtained, patients underwent standard polysomnography (PSG) and ALP evaluation simultaneously at the hospital (ALPlab), and repeated ALP at home (ALPhome) within 1 month...
July 1, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28667353/the-use-of-handheld-nasal-spirometry-to-predict-the-presence-of-obstructive-sleep-apnea
#12
Judd H Fastenberg, Christina H Fang, Viraj M Patel, Juan Lin, Howard D Stupak
OBJECTIVE: Nasal obstruction and oral breathing may play an important role in the pathophysiology of obstructive sleep apnea (OSA). This study aims to better understand the link between oral breathing, nasal obstruction, and the spectrum of sleep-disordered breathing. STUDY DESIGN: Prospective study. METHODS AND MATERIALS: Prospective study of patients who presented to the Otolaryngology clinic and underwent polysomnogram (PSG) from 2015 to 2016...
June 30, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28665356/sleep-apnea-and-hypoventilation-in-patients-with-down-syndrome-analysis-of-144-polysomnogram-studies
#13
Zheng Fan, Mihye Ahn, Heidi L Roth, Leping Li, Bradley V Vaughn
Patients with Down syndrome (DS) are at risk for both obstructive sleep apnea (OSA) and central sleep apnea (CSA); however, it is unclear how these components evolve as patients age and whether patients are also at risk for hypoventilation. A retrospective review of 144 diagnostic polysomnograms (PSG) in a tertiary care facility over 10 years was conducted. Descriptive data and exploratory correlation analyses were performed. Sleep disordered breathing was common (seen in 78% of patients) with an average apnea-hypopnea index (AHI) = 10...
June 30, 2017: Children
https://www.readbyqxmd.com/read/28663598/cost-effectiveness-strategies-in-osas-management-a-short-review
#14
D M Toraldo, D Passali, A Sanna, F De Nuccio, L Conte, M De Benedetto
Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objective testing. OSAS patients with any clinical evidence of comorbidities must be studied using simplified and less expensive systems such as Home Sleep Testing (HST)...
June 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28652835/a-randomized-controlled-trial-to-validate-the-alice-pdx-ambulatory-device
#15
Georg Nilius, Ulrike Domanski, Maik Schroeder, Karl-Josef Franke, Anke Hogrebe, Laurent Margarit, Maria Stoica, Marie-Pia d'Ortho
BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent condition; however, the majority of patients remain undiagnosed. There is a potential to expand the diagnostic capacity of sleep laboratories. The study objective was to validate a portable respiratory monitoring device (Alice PDX) against polysomnography (PSG) in the laboratory and to assess its reliability at home. METHODS: A total of 85 patients with suspected OSA (80% male, mean age 49.1±13.5 years, body mass index 29...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28649589/data-supporting-the-anticancer-activity-of-posterior-salivary-gland-psg-toxin-from-the-cuttlefish-sepia-pharaonis-ehrenberg-1831
#16
Ramachandran Karthik, Venkatesan Manigandan, Kumar Ebenezar, Raghavan Vijayashree, Ramachandran Saravanan
The data presented illustrated the in vitro anti-proliferative effect of the PSG toxin from the cuttlefish, Sepia pharaonis. The cytostatic potentials of the PSG toxin were determined by the lymphocyte migration inhibition assay. The PSG toxin (50 μg/ml) exhibited commendable inhibition of the migration of lymphocytes across the agarose gel matrix under the presence of lipopolysaccharide mitogen, with a mean migration index of 0.625. The cytotoxicity of the PSG toxin against selected cancer cell lines was determined using the MTT assay...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28647854/the-influence-of-head-of-bed-elevation-in-patients-with-obstructive-sleep-apnea
#17
Fábio José Fabrício de Barros Souza, Pedro Rodrigues Genta, Albino José de Souza Filho, Andrew Wellman, Geraldo Lorenzi-Filho
PURPOSE: The purpose of this study is to test the effects of a mild degree of head-of-bed elevation (HOBE) (7.5°) on obstructive sleep apnea (OSA) severity and sleep quality. METHODS: OSA patients were recruited from a single sleep clinic (Criciúma, Santa Catarina, Brazil). Following a baseline polysomnography (PSG), all patients underwent a PSG with HOBE (within 2 weeks). In addition, a subset of patients performed a third PSG without HOBE. RESULTS: Fifty-two patients were included in the study (age 53...
June 24, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28645471/association-of-obstructive-sleep-apnea-with-subclinical-cardiovascular-disease-predicted-by-coronary-artery-calcium-score-in-asymptomatic-subjects
#18
Min Young Seo, Jin-Young Lee, Joo-Yong Hahn, Gwanghui Ryu, Sang Duk Hong, Hun-Jong Dhong, Seung-Kyu Chung, Hyo Yeol Kim
The aim of this study is to determine the association among various sleep parameters for obstructive sleep apnea (OSA) and subclinical cardiovascular disease measured by coronary artery calcium (CAC) score. A cross-sectional study was conducted among 461 patients who underwent both polysomnography (PSG) and coronary artery computed tomography to evaluate CAC score. For each participant, coronary artery computed tomography was conducted within 12 months of PSG. We evaluated the possible association among various PSG parameters by evaluating overnight-attended PSG and CAC...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28633722/characterization-of-patients-who-present-with-insomnia-is-there-room-for-a-symptom-cluster-based-approach
#19
Megan R Crawford, Diana A Chirinos, Toni Iurcotta, Jack D Edinger, James K Wyatt, Rachel Manber, Jason C Ong
STUDY OBJECTIVES: This study examined empirically derived symptom cluster profiles among patients who present with insomnia using clinical data and polysomnography. METHODS: Latent profile analysis was used to identify symptom cluster profiles of 175 individuals (63% female) with insomnia disorder based on total scores on validated self-report instruments of daytime and nighttime symptoms (Insomnia Severity Index, Glasgow Sleep Effort Scale, Fatigue Severity Scale, Beliefs and Attitudes about Sleep, Epworth Sleepiness Scale, Pre-Sleep Arousal Scale), mean values from a 7-day sleep diary (sleep onset latency, wake after sleep onset, and sleep efficiency), and total sleep time derived from an in-laboratory PSG...
July 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28633091/cyclic-alternating-pattern-and-interictal-epileptiform-discharges-during-morning-sleep-after-sleep-deprivation-in-temporal-lobe-epilepsy
#20
Filippo Sean Giorgi, Michelangelo Maestri, Melania Guida, Luca Carnicelli, Lorenzo Caciagli, Raffaele Ferri, Ubaldo Bonuccelli, Enrica Bonanni
PURPOSE: Sleep deprivation (SD) increases the occurrence of interictal epileptiform discharges (IED) compared to basal EEG in temporal lobe epilepsy (TLE). In adults, EEG after SD is usually performed in the morning after SD. We aimed to evaluate whether morning sleep after SD bears additional IED-inducing effects compared with nocturnal physiological sleep, and whether changes in sleep stability (described by the cyclic alternating pattern-CAP) play a significant role. METHODS: Adult patients with TLE underwent in-lab night polysomnography (n-PSG) and, within 7days from n-PSG, they underwent also a morning EEG after night SD (SD-EEG)...
June 17, 2017: Epilepsy & Behavior: E&B
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