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Ingo Fietze, Charlotte Barthe, Matthias Hölzl, Martin Glos, Sandra Zimmermann, Ralf Bauer-Diefenbach, Thomas Penzel
INTRODUCTION: Noise is one of the factors that can seriously disturb sleep, and sound volume is an important factor in this context. One strategy involves avoiding exposure to sounds in the night, while entail the minimization of background noise in a bedroom. The goal of this study was to investigate the effect of systematic sound attenuation on nocturnal sleep by influencing sound volume and reverberation within the context of room acoustics. MATERIALS AND METHODS: On this basis, we designed a randomized, controlled crossover trial investigating 24 healthy sleepers (15 men and 9 women, aged 24...
September 2016: Noise & Health
Yoshikiyo Ono, Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Yasuhiro Igarashi, Masahiro Nezu, Yuta Tezuka, Hiromasa Ogawa, Sadayoshi Ito, Fumitoshi Stash
OBJECTIVE: Primary aldosteronism (PA) and sleep apnea syndrome (SAS) are common form of secondary hypertension. Some papers reported the group of high risk of SAS was higher rate of complication with PA than that of low risk of SAS. However, there are few reports which evaluated CPAP implementation rate of the PA patients with SAS diagnosing by Polysomnography (PSG). We aim to clarify clinical characteristics of patients of PA with SAS. DESIGN AND METHOD: We screened with Apnomonitor 284 PA patients who underwent adrenal venous sampling (AVS)...
September 2016: Journal of Hypertension
Martin Wolley, Diane Cowley, Ashraf Ahmed, Richard Gordon, Michael Stowasser
OBJECTIVE: Obstructive sleep apnoea (OSA) is known to commonly co-exist with primary aldosteronism (PA), but it is unknown if treatment via mineralocorticoid receptor blockade or adrenalectomy (for aldosterone producing adenoma, APA), improves sleep apnoea parameters in these patients. We therefore aimed to determine if specific medical or surgical treatment of PA improves OSA, as measured by the apnoea hypopnoea index (AHI). DESIGN AND METHOD: Patients undergoing diagnostic workup for PA were recruited if they had symptoms suggestive of OSA...
September 2016: Journal of Hypertension
Mitsuo Kuwabara, Satoshi Hoshide, Haruna Hamasaki, Toshikazu Shiga, Kazuomi Kario
OBJECTIVE: Obstructive sleep apnea (OSA) causes blood pressure (BP) surge while OSA episode occurs which could lead to increase the cardiovascular risk. We recently developed a triggered nocturnal BP monitoring (TNP) that initiates BP measurement when oxygen desaturation falls below a variable threshold. In this study, we evaluated the distribution of the nocturnal BP parameters measured by TNP, classification of nocturnal hypertension(HT) and its reproducibility. DESIGN AND METHOD: 147 outpatients in whom polysomnography (PSG) was planned for the diagnosis of OSA (mean age 59...
September 2016: Journal of Hypertension
Chia Lin Chang, Chia Yu Chang, Da Xian Lee, Po Jen Cheng
Pre-eclampsia is a pregnancy-specific hypertensive disorder that affects 2-8 % of pregnancies. This disorder can lead to seizure, multi-organ failure and maternal death. The best approach to prevent pre-eclampsia-associated adverse outcomes is to be able to prevent pre-eclampsia as early as possible. Unfortunately, current diagnostic methods are ineffective at predicting the risk of pre-eclampsia during early pregnancy. In humans, low levels of a group of placenta-derived Pregnancy Specific Glycoproteins (PSGs) have been associated with intrauterine growth retardation and pre-eclampsia and there is a significant enrichment of cases with deletions in the PSG gene locus in pre-eclampsia patients...
2016: Advances in Experimental Medicine and Biology
Wenjie Huang, Mahalakshmi Rangabashyam, Ying Hao, Jiaying Liu, Song Tar Toh
INTRODUCTION: This study aimed to determine the impact of obstructive sleep apnoea (OSA) on quality of life (QOL) and evaluate the utility of polysomnographic parameters in reflecting QOL. MATERIALS AND METHODS: Eighty-eight patients who underwent polysomnography (PSG) between December 2010 and November 2012 consecutively were recruited and they completed the 36-Item Short-Form Health Survey (SF-36) and Epworth Sleepiness Scale (ESS) questionnaires. Based on the apnoea-hypopnoea index (AHI), patients were classified as primary snorers (AHI <5), suffering from mild (5 ≤15), moderate (15 ≤30) or severe OSA (≥30)...
September 2016: Annals of the Academy of Medicine, Singapore
Thomas Roth, Jed Black, Raymond Cluydts, Pascal Charef, Marzia Cavallaro, Fabrice Kramer, Gary Zammit, James Walsh
OBJECTIVE: Sleep laboratory study to determine the dose-related efficacy and safety of almorexant in elderly patients with primary chronic insomnia. METHODS: Patients aged ≥65 years with primary insomnia were enrolled into a prospective, randomized, double-blind, placebo-controlled, multicenter dose-finding study with a five-period, five-way Latin square cross-over design. Patients were randomized to one of 10 unique sequences of two-night treatment with oral almorexant 25, 50, 100, or 200 mg capsules, or matching placebo...
October 10, 2016: Sleep
Jaspal Singh, R K Sharma, A K Gupta
Computers are used extensively in sleep labs for polysomnography and for assistance in sleep staging. However, the test is highly inconvenient to the patient and requires availability of specially equipped sleep labs. Alternative approaches that enable unobtrusive in-home sleep staging with ECG or other signals are highly desirable. In this paper we describe a method that can be used for distinction of REM and NREM sleep stages using spectral and non-linear features of ECG derived RR interval series. To test the accuracy of the system, we extracted the RR interval series from sleep studies of 20 young healthy individuals...
September 23, 2016: Computers in Biology and Medicine
I M Madaeva, O N Berdina, N V Semenova, L A Grebenkina, V V Madaev, L I Kolesnikova
AIM: To reveal gender characteristics of the sleep structure in obstructive sleep apnea syndrome (OSAS) during polysomnographic monitoring (PSGM). SUBJECTS AND METHODS: According to the results of a pre-survey using an apnea screening questionnaire, the investigation included 58 women (body mass index (BMI), 38.2±2.1 kg/m2) and 75 men (BMI, 34.2±1.8 kg/m2), aged 50-55 years, who complained about snoring, sleep apnea, and daytime hypersomnia. Copy-pair groups were formed and compared after objectively confirming the diagnosis by PSGM made at a specialized sleep laboratory, by applying the GRASS-TELEFACTOR Twin PSG system (Comet) with an integrated SPM-1 sleep module (USA) in accordance with the standard procedure...
2016: Terapevticheskiĭ Arkhiv
Maria Pia Villa, Hanaa Shafiek, Melania Evangelisti, Jole Rabasco, Manuela Cecili, Marilisa Montesano, Mario Barreto
The sleep clinical record (SCR) may be a valid method for detecting children with obstructive sleep apnoea (OSA). This study aimed to evaluate whether there were differences in SCR depending on age and to identify the possible risk factors for OSA development. We enrolled children with sleep disordered breathing between 2013 and 2015, and divided them according to age into preschool- and school-age groups. All patients underwent SCR and polysomnography. OSA was detected in 81.1% and 83.6% of preschool- and school-age groups, respectively...
January 2016: ERJ Open Research
K A Waters, A Lowe, P Cooper, S Vella, Hiran Selvadurai
BACKGROUND: In Cystic Fibrosis (CF), early detection and treatment of respiratory disease is considered the standard for respiratory care. Overnight polysomnography (PSG) may help identify respiratory deterioration in young patients with CF. METHODS: A prospective cohort study of 46 patients with CF, aged 8-12years, from a specialist clinic in a tertiary paediatric hospital. Daytime pulmonary function, shuttle test exercise testing and overnight PSG were studied...
October 8, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Jae Hoon Cho, Hyun Jun Kim
PURPOSE: The aim of the study was to investigate cardiopulmonary coupling (CPC) as a tool for evaluating the efficacy of continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA). METHOD: The medical records of patients who had undergone either standard polysomnography (PSG-only group, n = 62) or split-night CPAP titration (CPAP titration group, n = 115) due to habitual snoring or sleep apnea were analyzed. RESULT: The apnea-hypopnea index, CPC variables, and sleep stage (%) during the first 2 h of the sleep study did not differ between the PSG-only and CPAP titration groups...
October 8, 2016: Sleep & Breathing, Schlaf & Atmung
Gyambo Sithey, Li Ming Wen, Patrick Kelly, Mu Li
STUDY OBJECTIVES: Our aim was to identify clinical predictors associated with changes in settings for pediatric invasive and noninvasive positive airway pressure therapy, which could help inform the allocation of limited polysomnogram (PSG) resources. METHODS: A retrospective review was conducted in children who underwent one or more PSGs for technology titration. Children were included if they were using continuous positive airway pressure (CPAP) therapy, bilevel positive airway pressure (BPAP) therapy, or invasive positive pressure ventilation (IPPV) the night of the PSG...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Patrick H Finan, Jessica M Richards, Charlene E Gamaldo, Dingfen Han, Jeannie Marie Leoutsakos, Rachel Salas, Michael R Irwin, Michael T Smith
OBJECTIVE: To evaluate the validity of an ambulatory electroencephalographic (EEG) monitor for the estimation of sleep continuity and architecture in healthy adults. METHODS: Healthy, good sleeping participants (N = 14) were fit with both an ambulatory EEG monitor (Sleep Profiler) and a full polysomnography (PSG) montage. EEG recordings were gathered from both devices on the same night, during which sleep was permitted uninterrupted for eight hours. The study was set in an inpatient clinical research suite...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Bojan Gavrilovic, T Douglas Bradley, Daniel Vena, Owen D Lyons, Joseph M Gabriel, Milos R Popovic, Azadeh Yadollahi
OBJECTIVES: Obstructive sleep apnea (OSA) is highly prevalent in patients with fluid-retaining conditions. Using bioimpedance measurements, previous studies have shown that the greater the amount of fluid redistributed from the legs to the neck overnight, the greater the severity of OSA. Our objective was to investigate factors that predispose the development or worsening of OSA in response to experimental fluid overload. METHODS: Fifteen normotensive and non-obese adult men with and without OSA underwent polysomnography (PSG) during which normal saline was infused intravenously at a minimal rate to keep the vein open (control) or as a bolus of 22 ml/kg body weight (approximately 2 L) in a random order and crossed over after a week...
July 2016: Sleep Medicine
Shery Goril, Dora Zalai, Louise Scott, Colin M Shapiro
OBJECTIVES: Caregivers describe significant sleep disturbances in the vast majority of children and adolescents, which is diagnosed as fetal alcohol spectrum disorders (FASD), but objective data on sleep disorders in this population are almost completely lacking. Animal models suggest that intrauterine alcohol exposure may disrupt sleep wake patterns, cause sleep fragmentation, and specifically affect the suprachiasmatic nucleus, thus disrupting melatonin secretion. The objective of this pioneering study was to evaluate sleep and melatonin abnormalities in children with FASD using objective, gold-standard measures...
July 2016: Sleep Medicine
Abdulghani Sankari, Sukanya Pranathiageswaran, Scott Maresh, Arwa Mohammad Hosni, M Safwan Badr
RATIONALE: Current scoring criteria of non-apneic events (i.e. hypopnea) require the presence of oxyhemoglobin de-saturation and/or arousal. However, other sleep study parameters may help to identify abnormal respiratory events and assist in making more accurate diagnosis. OBJECTIVES: To investigate whether non-apneic respiratory events without de-saturation or cortical arousal are associated with respiratory and cardiac consequences. METHODS: Thirteen participants with sleep disturbances (snoring and/or excessive day time sleepiness), were screened using attended in laboratory polysomnography (PSG) while monitoring pressure and airflow via a nasal mask with an attached pneumotach...
September 26, 2016: Sleep
Sara Marelli, Paola M V Rancoita, Federica Giarrusso, Andrea Galbiati, Marco Zucconi, Alessandro Oldani, Clelia Di Serio, Luigi Ferini-Strambi
We validated the Italian version of the rapid eye movement sleep behavior disorder (RBD) screening questionnaire (RBDSQ) and calculated its cut-off value for discriminating RBD group from other sleep disorders and healthy controls (HC). 380 patients with sleep disorders and 101 HC were enrolled. RBDSQ achieved an acceptable Cronbach's α value of 0.787 and item 10 was the only one with a very low item-total biserial correlation (0.141). At ROC analysis, we obtained an AUC of 0.888, denoting a good performance of the RBDSQ total score for predicting the RBD status...
September 26, 2016: Journal of Neurology
Yuliya Boyko, Poul Jennum, Miki Nikolic, René Holst, Helle Oerding, Palle Toft
PURPOSE: To determine if improving intensive care unit (ICU) environment would enhance sleep quality, assessed by polysomnography (PSG), in critically ill mechanically ventilated patients. MATERIALS AND METHODS: Randomized controlled trial, crossover design. The night intervention "quiet routine" protocol was directed toward improving ICU environment between 10pm and 6am. Noise levels during control and intervention nights were recorded. Patients on mechanical ventilation and able to give consent were eligible for the study...
September 10, 2016: Journal of Critical Care
Süheyla Doğan Bulut, Serdar Bulut, Dicle Görkem Atalan, Rıza Gökçer Tulaci, Türker Türker, Eda Gürçay, Çiğdem Aydemir
BACKGROUND: The aim of this study was to compare the bone mineral density (BMD) of male schizophrenia patients with those of healthy controls in order to determine the relationship between BMD and hormonal changes. SUBJECTS AND METHODS: The study sample included male outpatients between 18 and 55 years old, diagnosed with schizophrenia who had used prolactin-raising antipsychotics (n=23) and prolactin-sparing antipsychotics (n=19) for at least twelve months, along with an age - matched healthy control group...
September 2016: Psychiatria Danubina
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