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https://www.readbyqxmd.com/read/28738456/-cost-effectiveness-of-community-based-treatment-of-chronic-hepatitis-b-in-china
#1
S X Zhang, P C Yang, Y L Cai, Y Lin, Y H Zou
Objective: Since eliminating hepatitis B in China would need considerable public health resources, the economics problem of the strategy of community-based antiviral treatment for chronic hepatitis B (CHB) has become an important issue. The cost-effectiveness and affordability of the strategy were evaluated in this study. Methods: According to the advocacy on eliminating hepatitis B by WHO and the comprehensive protocol of community based prevention of major infectious diseases and the guideline for CHB prevention and treatment in China, the decision analytic Markov model was constructed with the parameters from national surveys or Meta-analysis...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738455/-cost-effectiveness-and-affordability-of-strategy-for-preventing-mother-to-child-transmission-of-hepatitis-b-in-china
#2
Y Lin, S X Zhang, P C Yang, Y L Cai, Y H Zou
Objective: To evaluate the cost effectiveness of nationwide prevention of mother to child transmission (PMTCT) strategy for hepatitis B, and estimate the willing to pay and budget impacts on the PMTCT. Methods: The decision analytic Markov model for the PMTCT was constructed and a birth cohort of Chinese infants born in 2013 was used to calculate the cost-effectiveness of the PMTCT among them compared with those receiving no intervention. The parameters in the model were obtained from literatures of national surveys or Meta-analysis...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738454/-development-of-markov-models-for-economics-evaluation-of-strategies-on-hepatitis-b-vaccination-and-population-based-antiviral-treatment-in-china
#3
P C Yang, S X Zhang, P P Sun, Y L Cai, Y Lin, Y H Zou
Objective: To construct the Markov models to reflect the reality of prevention and treatment interventions against hepatitis B virus (HBV) infection, simulate the natural history of HBV infection in different age groups and provide evidence for the economics evaluations of hepatitis B vaccination and population-based antiviral treatment in China. Methods: According to the theory and techniques of Markov chain, the Markov models of Chinese HBV epidemic were developed based on the national data and related literature both at home and abroad, including the settings of Markov model states, allowable transitions and initial and transition probabilities...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28737384/physicochemical-parameters-affecting-the-electrospray-ionization-efficiency-of-amino-acids-after-acylation
#4
Jos Hermans, Sara Ongay, Vadym Markov, Rainer Bischoff
Electrospray ionization (ESI) is widely used in liquid chromatography coupled to mass spectrometry (LC-MS) for the analysis of biomolecules. However, the ESI process is still not completely understood and it is often a matter of trial and error to enhance ESI efficiency and hence the response of a given set of compounds. In this work we performed a systematic study of the ESI response of 14 amino acids that were acylated with organic acid anhydrides of increasing chain length and with polyethylene glycol (PEG) changing certain physicochemical properties in a predictable manner...
July 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28736505/estimating-the-cost-effectiveness-of-daclatasvir%C3%A2-%C3%A2-sofosbuvir-versus-sofosbuvir%C3%A2-%C3%A2-ribavirin-for-patients-with-genotype-3-hepatitis-c-virus
#5
Phil McEwan, Samantha Webster, Thomas Ward, Michael Brenner, Anupama Kalsekar, Yong Yuan
BACKGROUND: As treatments for chronic hepatitis C are moving away from interferon-containing regimens, the most appropriate allocation of resources to higher cost, interferon-free, direct-acting antiviral (DAA) regimens needs to be assessed. Hepatitis C virus (HCV) genotype 3 is associated with faster disease progression and has fewer treatment options, historically, than other HCV genotypes. This analysis aims to estimate the comparative cost-effectiveness of two recently licenced interferon-free regimens for the treatment of HCV genotype 3...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28734305/exploring-the-free-energy-gain-of-phase-separation-via-markov-state-modeling
#6
Myra Biedermann, Andreas Heuer
The gain of free energy upon unmixing is determined via application of Markov state modeling (MSM), using an Ising model with a fixed number of up- and down-spins. MSM yields reasonable estimates of the free energies. However, a closer look reveals significant differences that point to residual non-Markovian effects. These non-Markovian effects are rather unexpected since the typical criteria to study the quality of Markovianity indicate complete Markovian behavior. We identify the sparse connectivity between different Markov states as a likely reason for the observed bias...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734126/german-estsmoke-estimating-adult-smoking-related-costs-and-consequences-of-smoking-cessation-for-germany
#7
Diana Sonntag, Simon Gilbody, Winkler Volker, Shehzad Ali
AIMS: We compared predicted lifetime health care costs for current, never and ex-smokers in Germany under the current set of tobacco control polices. We compared these economic consequences of the current situation with an alternative in which Germany were to implement more comprehensive tobacco control policies consistent with the WHO Framework Convention for Tobacco Control (FCTC) guidelines. DESIGN: German EstSmoke, an adapted version of the UK EstSmoke simulation model, applies the Markov modelling approach...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28734092/disentangling-the-role-of-seed-bank-and-dispersal-in-plant-metapopulation-dynamics-using-patch-occupancy-surveys
#8
F Manna, R Pradel, R Choquet, H Fréville, P-O Cheptou
In plants, the presence of a seed bank challenges the application of classical metapopulation models to above-ground presence surveys; ignoring seed bank leads to overestimated extinction and colonization rates. In this article, we explore the possibility to detect seed bank using hidden Markov models in the analysis of above-ground patch occupancy surveys of an annual plant with limited dispersal. Patch occupancy data were generated by simulation under two metapopulation sizes (N = 200 and N = 1000 patches) and different metapopulation scenarios, each scenario being a combination of the presence/absence of a one-year seed bank and the presence/absence of limited dispersal in a circular 1-dimension configuration of patches...
July 22, 2017: Ecology
https://www.readbyqxmd.com/read/28733120/employing-decomposable-partially-observable-markov-decision-processes-to-control-gene-regulatory-networks
#9
Utku Erdogdu, Faruk Polat, Reda Alhajj
OBJECTIVE: Formulate the induction and control of gene regulatory networks (GRNs) from gene expression data using Partially Observable Markov Decision Processes (POMDPs). METHODS AND MATERIAL: Different approaches exist to model GRNs; they are mostly simulated as mathematical models that represent relationships between genes. Actually, it has been realized that biological functions at the cellular level are controlled by genes; thus, by controlling the behavior of genes, it is possible to regulate these biological functions...
July 18, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28732231/kernel-dynamic-policy-programming-applicable-reinforcement-learning-to-robot-systems-with-high-dimensional-states
#10
Yunduan Cui, Takamitsu Matsubara, Kenji Sugimoto
We propose a new value function approach for model-free reinforcement learning in Markov decision processes involving high dimensional states that addresses the issues of brittleness and intractable computational complexity, therefore rendering the value function approach based reinforcement learning algorithms applicable to high dimensional systems. Our new algorithm, Kernel Dynamic Policy Programming (KDPP) smoothly updates the value function in accordance to the Kullback-Leibler divergence between current and updated policies...
June 29, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28730802/sensing-single-molecule-penetration-into-nanopores-pushing-the-time-resolution-to-the-diffusion-limit
#11
Igor Bodrenko, Jiajun Wang, Samuele Salis, Mathias Winterhalter, Matteo Ceccarelli
To quantify small molecule penetration into and eventually permeation through nanopores, we applied an improved excess-noise analysis of the ion current fluctuation caused by entering molecules. The kinetic parameters of substrate entry and leave are derived from a two-state Markov model, analyzing the substrate concentration depen- dence of the average ion current and its variance. Including filter corrections allows one to detect the transition rates beyond the cutoff frequency, fc, of the instrumental ion-current filter...
July 21, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28729321/economic-evaluation-of-a-brief-counselling-for-smoking-cessation-in-dentistry-a-case-study-comparing-two-health-economic-models
#12
Suvi Erika Virtanen, Maria R Galanti, Pia M Johansson, Inna Feldman
OBJECTIVES: This study aimed to compare the cost-effectiveness estimates of a brief counselling of smoking cessation in dentistry by using two different health economic models. DESIGN AND OUTCOME MEASURES: Intervention effectiveness was estimated in a cluster randomised controlled trial. The number of quitters was estimated based on 7-day abstinence and on smoking reduction at follow-up. Health economic evaluation was performed using two models: (1) a population-based model employing potential impact fractions and (2) a Markov model estimating the cost-effectiveness of the intervention for the actual participants...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28728094/modelling-a-budgetary-impact-analysis-for-funding-drug-based-smoking-cessation-therapies-for-patients-with-major-depressive-disorder-in-spain
#13
J Rejas-Gutiérrez, E Bruguera, S Cedillo
BACKGROUND: Smoking is associated with high healthcare resource utilisation and cost to society. Patients with major depressive disorder (MDD) exhibit high susceptibility to nicotine dependence. Varenicline, bupropion and nicotine replacement therapy are all indicated for smoking cessation; however funding by the Spanish national health system (SNHS) is limited. We modelled a budgetary impact analysis (BIA) to estimate the impact of the SNHS funding drug-based therapies for smoking cessation in smokers with MDD...
June 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28726751/an-adaptive-feature-learning-model-for-sequential-radar-high-resolution-range-profile-recognition
#14
Xuan Peng, Xunzhang Gao, Yifan Zhang, Xiang Li
This paper proposes a new feature learning method for the recognition of radar high resolution range profile (HRRP) sequences. HRRPs from a period of continuous changing aspect angles are jointly modeled and discriminated by a single model named the discriminative infinite restricted Boltzmann machine (Dis-iRBM). Compared with the commonly used hidden Markov model (HMM)-based recognition method for HRRP sequences, which requires efficient preprocessing of the HRRP signal, the proposed method is an end-to-end method of which the input is the raw HRRP sequence, and the output is the label of the target...
July 20, 2017: Sensors
https://www.readbyqxmd.com/read/28726530/incremental-net-monetary-benefit-of-ocrelizumab-relative-to-subcutaneous-interferon-%C3%AE-1a
#15
Melissa A Frasco, Tiffany Shih, Devin Incerti, Oliver Diaz Espinosa, Diana K Vania, Nina Thomas
AIM: Disease-modifying therapies (DMTs) impact the natural history of relapsing forms of multiple sclerosis (RRMS) by reducing annual relapse rates and slowing disability progression. The effect of DMTs on indirect costs has not been consistently explored in cost-effectiveness studies thus far. The value to patients of an emerging DMT, ocrelizumab, was quantified in comparison to subcutaneous interferon beta-1a (IFNβSC) for the prevalent RRMS population with mild to moderate disability in the United States based on two Phase 3 trials, OPERA I and OPERA II, of ocrelizumab versus IFNβSC in RRMS...
July 20, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28726404/predicting-optimal-deer-label-positions-to-study-protein-conformational-heterogeneity
#16
Shriyaa Mittal, Diwakar Shukla
Double electron-electron resonance (DEER) spectroscopy is a powerful experimental technique for understanding the conformational heterogeneity of proteins. It involves attaching nitroxide spin labels to two residues in the protein to obtain a distance distribution between them. However, the choice of residue pairs to label in the protein, requires cautious thought and experimentalists are required to pick label positions from a large set of all possible residue pair combinations in the protein. In this paper, we address the problem of the choice of DEER spin label positions in a protein...
July 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28725164/cost-effectiveness-of-cervical-cancer-screening-and-preventative-cryotherapy-at-an-hiv-treatment-clinic-in-kenya
#17
Marita R Zimmermann, Elisabeth Vodicka, Joseph B Babigumira, Timothy Okech, Nelly Mugo, Samah Sakr, Louis P Garrison, Michael H Chung
OBJECTIVE: This study evaluated the potential cost-effectiveness of cervical cancer screening in HIV treatment clinics in Nairobi, Kenya. METHODS: A Markov model was used to project health outcomes and costs of cervical cancer screening and cryotherapy at an HIV clinic in Kenya using cryotherapy without screening, visual inspection with acetic acid (VIA), Papanicolaou smear (Pap), and testing for human papillomavirus (HPV). Direct and indirect medical and non-medical costs were examined from societal and clinic perspectives...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28723943/stress-enhances-model-free-reinforcement-learning-only-after-negative-outcome
#18
Heyeon Park, Daeyeol Lee, Jeanyung Chey
Previous studies found that stress shifts behavioral control by promoting habits while decreasing goal-directed behaviors during reward-based decision-making. It is, however, unclear how stress disrupts the relative contribution of the two systems controlling reward-seeking behavior, i.e. model-free (or habit) and model-based (or goal-directed). Here, we investigated whether stress biases the contribution of model-free and model-based reinforcement learning processes differently depending on the valence of outcome, and whether stress alters the learning rate, i...
2017: PloS One
https://www.readbyqxmd.com/read/28723857/the-clinical-and-economic-effects-of-targeted-bowel-preparation-results-of-a-decision-analysis
#19
Jacob E Kurlander, Shahnaz Sultan, Sameer D Saini
BACKGROUND: Colonoscopy bowel preparation failure is common, costly, and clinically harmful. Prediction models can identify patients at high risk for preparation failure, but they are rarely used. GOALS: To investigate the clinical and economic effects of using a more intensive preparation upfront (a "targeted" strategy) for patients identified as high risk for preparation failure. STUDY: We developed a Markov decision analytic model to compare usual care with a targeted strategy...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723754/an-economic-analysis-of-high-dose-imatinib-dasatinib-and-nilotinib-for-imatinib-resistant-chronic-phase-chronic-myeloid-leukemia-in-china-a-cheers-compliant-article
#20
Bin Wu, Maobai Liu, Te Li, Houwen Lin, Hua Zhong
BACKGROUND: The aim of the study was to test the cost-effectiveness of dasatinib compared to high-dose imatinib and nilotinib in Chinese patients who were diagnosed with imatinib-resistant chronic myeloid leukemia in the chronic phase (CML-CP). METHODS: A Markov model combined with clinical effectiveness, utility, and cost data was used. The sensitivity analyses were conducted to determine the robustness of the model outcomes. The impact of patient assistance programs (PAPs) was assessed...
July 2017: Medicine (Baltimore)
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