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Health economic modeling

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https://www.readbyqxmd.com/read/29453841/beyond-cost-benefit-analysis-in-the-governance-of-synthetic-biology
#1
Wendell Wallach, Marc Saner, Gary Marchant
For many innovations, oversight fits nicely within existing governance mechanisms; nevertheless, others pose unique public health, environmental, and ethical challenges. Synthetic artemisinin, for example, has many precursors in laboratory-developed drugs that emulate natural forms of the same drug. The policy challenges posed by synthetic artemisinin do not differ significantly in kind from other laboratory-formulated drugs. Synthetic biofuels and gene drives, however, fit less clearly into existing governance structures...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29453763/testing-the-grossman-model-of-medical-spending-determinants-with-macroeconomic-panel-data
#2
Jochen Hartwig, Jan-Egbert Sturm
Michael Grossman's human capital model of the demand for health has been argued to be one of the major achievements in theoretical health economics. Attempts to test this model empirically have been sparse, however, and with mixed results. These attempts so far relied on using-mostly cross-sectional-micro data from household surveys. For the first time in the literature, we bring in macroeconomic panel data for 29 OECD countries over the period 1970-2010 to test the model. To check the robustness of the results for the determinants of medical spending identified by the model, we include additional covariates in an extreme bounds analysis (EBA) framework...
February 16, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29452560/health-care-efficiencies-consolidation-and-alternative-models-vs-health-care-and-antitrust-regulation-irreconcilable-differences
#3
Michael W King
Despite the U.S. substantially outspending peer high income nations with almost 18% of GDP dedicated to health care, on any number of statistical measurements from life expectancy to birth rates to chronic disease, 1 the U.S. achieves inferior health outcomes. In short, Americans receive a very disappointing return on investment on their health care dollars, causing economic and social strain. 2 Accordingly, the debates rage on: what is the top driver of health care spending? Among the culprits: poor communication and coordination among disparate providers, paperwork required by payors and regulations, well-intentioned physicians overprescribing treatments, drugs and devices, outright fraud and abuse, and medical malpractice litigation...
November 2017: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/29451660/economic-assessment-of-postoperative-pain-control-strategies-for-treatment-of-adult-patients-with-cancer
#4
Rafael Freitas Dos Santos, Fernando Bliacheriene, Flavia Mori Sarti
OBJECTIVE: The authors performed an economic assessment of opioids currently being used for control of postoperative pain relating to the surgical treatment of cancer (fentanyl and sufentanil) within the Brazilian Unified Health System (SUS, in the Portuguese acronym). METHOD: The assessment was based on the perspective of the government, in order to collaborate with the promotion of effectiveness in public policies of health, and to optimize the allocation of public resources into health...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451200/modulation-of-mitochondrial-bioenergetics-as-a-therapeutic-strategy-in-alzheimer-s-disease
#5
REVIEW
Isaac G Onyango
Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have not translated into any effective disease-modifying therapies. This could be because interventions are being tested too late in the disease process. While existing therapies provide symptomatic and clinical benefit, they do not fully address the molecular abnormalities that occur in AD neurons...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450599/a-typology-of-satisfaction-with-mental-health-services-based-on-andersen-s-behavioral-model
#6
Marilyn Fortin, Zhirong Cao, Marie-Josée Fleury
OBJECTIVE: Patients with mental disorders (MDs) form a highly heterogeneous group, whose satisfaction with mental health services (MHS) may vary according to different variables. Identifying patient subgroups with similar levels of satisfaction may help identify variables that contribute to satisfaction or dissatisfaction with services. This study established a typology of patient satisfaction with MHS that revealed variables specific to each group. METHODS: The study included 325 patients with MDs across four health service networks offering integrated and diversified services...
February 15, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29449500/the-cost-effectiveness-of-biannual-serum-urate-su-monitoring-after-reaching-target-in-gout-a-health-economic-analysis-comparing-su-monitoring
#7
Philip C Robinson, Nicola Dalbeth, Peter Donovan
OBJECTIVE: The 2012 American College of Rheumatology gout management guidelines recommend monitoring serum urate (SU) every 6 months after target SU has been achieved. Our objective was to determine through modeling whether this testing would be cost-effective, considering financial cost, quality of life, and estimated change in adherence. METHODS: A cost-utility analysis was completed with a 3-arm model: (1) no regular urate monitoring; (2) annual urate monitoring; and (3) biannual urate monitoring...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29446857/infectious-risk-of-biological-drugs-versus-traditional-systemic-treatments-in-moderate-to-severe-psoriasis-a-cohort-analysis-in-the-french-insurance-database
#8
Sylvain Couderc, Maryse Lapeyre-Mestre, Robert Bourrel, Paul Carle, Jean-Louis Montastruc, Agnès Sommet
The aim of this study was to compare the infectious risk between a group of psoriasis patients treated by Biological Drugs (BD) and a group treated by Traditional Systemic Treatments (TST). We built a retrospective observational cohort study from the French health insurance database in the Midi-Pyrénées area (2.9 million inhabitants, South West of France) using data from 01/01/2010 to 12/31/2013. We compared the infectious risk between 'exposed' patients treated with BD (adalimumab, etanercept, infliximab or ustekinumab) and 'unexposed' patients treated by TST (phototherapy, acitretin, methotrexate or cyclosporine)...
February 15, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29446343/cost-utility-analysis-of-antiviral-use-under-pandemic-influenza-using-a-novel-approach-linking-pharmacology-epidemiology-and-heath-economics
#9
D B C Wu, N Chaiyakunapruk, C Pratoomsoot, K K C Lee, H Y Chong, R E Nelson, P F Smith, C M Kirkpatrick, M A Kamal, K Nieforth, G Dall, S Toovey, D C M Kong, A Kamauu, C R Rayner
Simulation models are used widely in pharmacology, epidemiology and health economics (HEs). However, there have been no attempts to incorporate models from these disciplines into a single integrated model. Accordingly, we explored this linkage to evaluate the epidemiological and economic impact of oseltamivir dose optimisation in supporting pandemic influenza planning in the USA. An HE decision analytic model was linked to a pharmacokinetic/pharmacodynamics (PK/PD) - dynamic transmission model simulating the impact of pandemic influenza with low virulence and low transmissibility and, high virulence and high transmissibility...
February 15, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29445979/hispanic-immigrant-father-involvement-with-young-children-in-the-united-states-a-comparison-with-us-born-hispanic-and-white-non-hispanic-fathers
#10
Sylvia Guendelman, Juliet Nussbaum, Ann Soliday, Maureen Lahiff
Objectives Fathering is known to foster child development and health, yet evidence on Hispanic immigrant fathers' involvement with their young children is sparse. This study assessed disparities in pregnancy intendedness and father involvement with children ages 0-4 among Hispanic immigrant co-resident fathers versus two reference groups: US-born Hispanic and US-born White fathers. We hypothesized that differentials in involvement were associated with socioeconomic and cultural factors. Methods Using 2011-2013 data from the National Survey of Family Growth (N = 598), we performed bivariate, logistic and linear regression analyses to assess disparities in pregnancy intendedness and five father involvement outcomes (physical care, warmth, outings, reading and discipline)...
February 14, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29445964/different-methods-for-modelling-severe-hypoglycaemic-events-implications-for-effectiveness-costs-and-health-utilities
#11
Edna Keeney, Dalia Dawoud, Sofia Dias
BACKGROUND: Clinical trials report severe hypoglycaemic events as the number of patients with at least one event out of the total randomised or number of events for a given total exposure. Different network meta-analysis models have been used to analyse these different data types. OBJECTIVE: This aim of this article was to establish the impact of using the different models on effectiveness, costs and health utility estimates. METHODS: We analysed a dataset used in a recent network meta-analysis of severe hypoglycaemic events conducted to inform National Institute for Health and Care Excellence recommendations regarding basal insulin choice for patients with type 1 diabetes mellitus...
February 14, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29445850/factors-associated-with-household-food-insecurity-and-depression-in-pregnant-south-african-women-from-a-low-socio-economic-setting-a-cross-sectional-study
#12
Zulfa Abrahams, Crick Lund, Sally Field, Simone Honikman
PURPOSE: Food insecurity has been linked with maternal depression in low-income settings. Few studies have looked at factors associated with both food insecurity and maternal depression as outcomes. This study aimed to assess factors associated with food insecurity and depression in a sample of pregnant South African women. METHODS: We conducted a cross-sectional study at a Midwife Obstetric Unit in a low-income suburb in Cape Town. Pregnant women attending the clinic for their first antenatal visit were invited to participate...
February 14, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29444788/assessment-of-the-societal-and-individual-preferences-for-fertility-treatment-in-australia-study-protocol-for-stated-preference-discrete-choice-experiments
#13
Willings Botha, Natasha Donnolley, Marian Shanahan, Georgina M Chambers
INTRODUCTION: In Australia, societal and individual preferences for funding fertility treatment remain largely unknown. This has resulted in a lack of evidence about willingness to pay (WTP) for fertility treatment by either the general population (the funders) or infertile individuals (who directly benefit). Using a stated preference discrete choice experiment (SPDCE) approach has been suggested as a more appropriate method to inform economic evaluations of fertility treatment. We outline the protocol for an ongoing study which aims to assess fertility treatment preferences of both the general population and infertile individuals, and indirectly estimate their WTP for fertility treatment...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29444705/health-economic-evaluation-of-moist-wound-care-in-chronic-cutaneous-leishmaniasis-ulcers-in-afghanistan
#14
Hans-Christian Stahl, Faridullah Ahmadi, Sami Mohammad Nahzat, Heng-Jin Dong, Kurt-Wilhelm Stahl, Rainer Sauerborn
BACKGROUND: The present health economic evaluation in Afghanistan aims to support public health decision makers and health care managers to allocate resources efficiently to appropriate treatments for cutaneous leishmaniasis (CL) elicited by Leishmania tropica or Leishmania major. METHODS: A decision tree was used to analyse the cost and the effectiveness of two wound care regimens versus intra-lesional antimony in CL patients in Afghanistan. Costs were collected from a societal perspective...
February 14, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29444679/understanding-perceived-availability-and-importance-of-tobacco-control-interventions-to-inform-european-adoption-of-a-uk-economic-model-a-cross-sectional-study
#15
Puttarin Kulchaitanaroaj, Zoltán Kaló, Robert West, Kei Long Cheung, Silvia Evers, Zoltán Vokó, Mickael Hiligsmann, Hein de Vries, Lesley Owen, Marta Trapero-Bertran, Reiner Leidl, Subhash Pokhrel
BACKGROUND: The evidence on the extent to which stakeholders in different European countries agree with availability and importance of tobacco-control interventions is limited. This study assessed and compared stakeholders' views from five European countries and compared the perceived ranking of interventions with evidence-based ranking using cost-effectiveness data. METHODS: An interview survey (face-to-face, by phone or Skype) was conducted between April and July 2014 with five categories of stakeholders - decision makers, service purchasers, service providers, evidence generators and health promotion advocates - from Germany, Hungary, the Netherlands, Spain, and the United Kingdom...
February 14, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29444304/devolution-and-the-regional-health-divide-a-longitudinal-ecological-study-of-14-countries-in-europe
#16
R du Plessis, B S Milton, B Barr
Background: Greater regional devolution can reduce economic inequalities between regions; however, the impact on health inequalities is not clear. We investigated the association between changes over time in the level of devolution in European countries and regional economic and health inequalities. Methods: We used the proportion of government expenditure controlled by subnational levels of government as our measure of devolution in 14 European countries between 1995 and 2011...
February 1, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29444257/comparison-of-strategies-and-incidence-thresholds-for-vi-conjugate-vaccines-against-typhoid-fever-a-cost-effectiveness-modeling-study
#17
Nathan C Lo, Ribhav Gupta, Jeffrey D Stanaway, Denise O Garrett, Isaac I Bogoch, Stephen P Luby, Jason R Andrews
Background: Typhoid fever remains a major public health problem globally. While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear. We aimed to identify the strategies and associated epidemiologic conditions under which Vi conjugate vaccines would be cost-effective. Methods: We developed a dynamic, age-structured transmission and cost-effectiveness model that simulated multiple vaccination strategies with a typhoid Vi conjugate vaccine from a societal perspective...
February 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29442300/population-screening-for-hereditary-haemochromatosis-in-australia-construction-and-validation-of-a-state-transition-cost-effectiveness-model
#18
Barbara de Graaff, Lei Si, Amanda L Neil, Kwang Chien Yee, Kristy Sanderson, Lyle C Gurrin, Andrew J Palmer
INTRODUCTION: HFE-associated haemochromatosis, the most common monogenic disorder amongst populations of northern European ancestry, is characterised by iron overload. Excess iron is stored in parenchymal tissues, leading to morbidity and mortality. Population screening programmes are likely to improve early diagnosis, thereby decreasing associated disease. Our aim was to develop and validate a health economics model of screening using utilities and costs from a haemochromatosis cohort...
March 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29441504/statistical-alchemy-conceptual-validity-and-mapping-to-generate-health-state-utility-values
#19
Jeff Round, Annie Hawton
Mapping between non-preference- and preference-based health-related quality-of-life instruments has become a common technique for estimating health state utility values for use in economic evaluations. Despite the increased use of mapped health state utility estimates in health technology assessment and economic evaluation, the methods for deriving them have not been fully justified. Recent guidelines aim to standardise reporting of the methods used to map between instruments but do not address fundamental concerns in the underlying conceptual model...
December 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29441501/choosing-between-unicompartmental-and-total-knee-replacement-what-can-economic-evaluations-tell-us-a-systematic-review
#20
REVIEW
Edward Burn, Alexander D Liddle, Thomas W Hamilton, Sunil Pai, Hemant G Pandit, David W Murray, Rafael Pinedo-Villanueva
BACKGROUND AND OBJECTIVE: Patients with anteromedial arthritis who require a knee replacement could receive either a unicompartmental knee replacement (UKR) or a total knee replacement (TKR). This review has been undertaken to identify economic evaluations comparing UKR and TKR, evaluate the approaches that were taken in the studies, assess the quality of reporting of these evaluations, and consider what they can tell us about the relative value for money of the procedures. METHODS: A search of MEDLINE, EMBASE and the Centre for Reviews and Dissemination National Health Service Economic Evaluation Database was undertaken in January 2016 to identify relevant studies...
December 2017: PharmacoEconomics Open
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