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alakendu ghosh

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https://www.readbyqxmd.com/read/27721549/hepatic-and-hematological-adverse-effects-of-long-term-low-dose-methotrexate-therapy-in-rheumatoid-arthritis-an-observational-study
#1
Lily Dubey, Suparna Chatterjee, Alakendu Ghosh
OBJECTIVES: Methotrexate (MTX) is the most commonly used cost-effective disease-modifying antirheumatoid drug (DMARD). Its main dose-limiting adverse effects are hepatic and hematopoietic. This cross-sectional, observational study evaluated the prevalence of hepatic and hematological adverse effects with long-term low-dose MTX therapy. MATERIALS AND METHODS: Rheumatoid arthritis (RA) patients taking ≤15 mg/week MTX for at least 2 years were enrolled from the rheumatology outpatient department...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27529533/sensitivity-and-specificity-of-ultrasonographic-features-of-gout-in-intercritical-and-chronic-phase
#2
Shyamashis Das, Alakendu Ghosh, Parasar Ghosh, Debasish Lahiri, Pradyot Sinhamahapatra, Kaushik Basu
AIM: This study aimed to assess the sensitivity and specificity of ultrasonographic features of gout in intercritical and chronic stages and compared ultrasonographic features of gout between patients with persistent high serum uric acid (SUA) and patients with low SUA. METHODS: Adult patients with gout confirmed by demonstration of monosodium urate crystals were recruited, if they were in intercritical or chronic stage clinically. Ultrasonographic examination of the first metatarsophalangeal joints (MTPJs) and the knee joints of both sides were done by a blinded rheumatologist trained in musculoskeletal ultrasound...
August 16, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27492663/temporal-evolution-of-urate-crystal-deposition-over-articular-cartilage-after-successful-urate-lowering-therapy-in-patients-with-gout-an-ultrasonographic-perspective
#3
Shyamashis Das, Rudra Prosad Goswami, Alakendu Ghosh, Parasar Ghosh, Debasish Lahiri, Kaushik Basu
OBJECTIVE: To detect evolution of ultrasonographic signs of deposition of monosodium urate crystals (MSUC) in gouty joints by serial ultrasonography after initiation of urate-lowering therapy (ULT). METHODS: Adult gout patients were examined by serial ultrasonography after initiation of ULT with target serum uric acid (SUA) < 6 mg/dL. RESULTS: Thirty-eight male patients with gout with mean age of 50 ± 11 years, median disease duration of 48 months and baseline mean SUA level of 8...
August 5, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27318361/shrinking-lung-syndrome-in-systemic-lupus-erythematosus-successfully-treated-with-rituximab
#4
R P Goswami, S Mondal, D Lahiri, K Basu, S Das, P Ghosh, A Ghosh
No abstract text is available yet for this article.
September 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/26316576/ultrasound-is-a-useful-adjunct-in-diagnosis-of-eosinophilic-fasciitis
#5
COMPARATIVE STUDY
Sumantro Mondal, Rudra Prosad Goswami, Debanjali Sinha, Alakendu Ghosh
No abstract text is available yet for this article.
November 2015: Rheumatology
https://www.readbyqxmd.com/read/26050104/itolizumab-in-combination-with-methotrexate-modulates-active-rheumatoid-arthritis-safety-and-efficacy-from-a-phase-2-randomized-open-label-parallel-group-dose-ranging-study
#6
Arvind Chopra, S Chandrashekara, Rajgopalan Iyer, Liza Rajasekhar, Naresh Shetty, Sarathchandra Mouli Veeravalli, Alakendu Ghosh, Mrugank Merchant, Jyotsna Oak, Vikram Londhey, Abhijit Barve, M S Ramakrishnan, Enrique Montero
The objective of this study was to assess the safety and efficacy of itolizumab with methotrexate in active rheumatoid arthritis (RA) patients who had inadequate response to methotrexate. In this open-label, phase 2 study, 70 patients fulfilling American College of Rheumatology (ACR) criteria and negative for latent tuberculosis were randomized to four arms: 0.2, 0.4, or 0.8 mg/kg itolizumab weekly combined with oral methotrexate, and methotrexate alone (2:2:2:1). Patients were treated for 12 weeks, followed by 12 weeks of methotrexate alone during follow-up...
April 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/25983498/a-study-of-the-prevalence-of-osteoporosis-and-hypovitaminosis-d-in-patients-with-primary-knee-osteoarthritis
#7
Biswadip Ghosh, Tanmoy Pal, Satyabrata Ganguly, Alakendu Ghosh
INTRODUCTION: Osteoarthritis and Osteoporosis are highly prevalent disease, so is hypovitaminosis D. We tried to find out prevalence of osteoporosis and hypovitaminosis D in patients suffering from primary knee Osteoarthritis. We also compared the prevalence of oseotoporosis between general population and patients of primary osteoarthritis. METHODS: Patients suffering from primary knee OA were taken from Rheumatology OPD of Medical College Hospital and SSKM Hospital Kolkata, India...
December 2014: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/25662385/a-classical-image-of-dumbbell-shaped-neurofibroma
#8
Tony Ete, Sumantro Mondal, Debanjali Sinha, Jyotirmoy Pal, Alakendu Ghosh
No abstract text is available yet for this article.
January 30, 2015: New Zealand Medical Journal
https://www.readbyqxmd.com/read/24914033/ultrasonography-as-a-useful-modality-for-documenting-sacroiliitis-in-radiographically-negative-inflammatory-back-pain-a-comparative-evaluation-with-mri
#9
COMPARATIVE STUDY
Alakendu Ghosh, Sumantro Mondal, Debanjali Sinha, Arijit Nag, Sumit Chakraborty
OBJECTIVES: The aims of this study were to identify and characterize features of sacroiliitis in patients with non-radiographic inflammatory low back pain by ultrasonography (USG) and to correlate the findings with that of MRI. METHODS: MRI and USG of SI joints were performed on 29 patients who fulfilled the definition of inflammatory low back pain according to the Assessment of SpondyloArthritis International Society 2009 criteria for axial SpA but were X-ray negative for sacroiliitis...
November 2014: Rheumatology
https://www.readbyqxmd.com/read/24818335/early-structured-disease-modifying-anti-rheumatic-drug-dmard-therapy-reduces-cardiovascular-risk-in-rheumatoid-arthritis-a-single-centre-study-using-non-biologic-drugs
#10
Sumit Chatterjee, Pankaj Sarkate, Sudip Ghosh, Monodeep Biswas, Alakendu Ghosh
BACKGROUND: Rheumatoid arthritis, being a chronic disease requires long-term management of patients with drugs. The increasing cost of biologics in this era of disease management led us to devise a treatment regime, optimal for use in a developing country like India, which was economical as well as effective in controlling disease activity. OBJECTIVE: To investigate if combination therapy with DMARDs can reduce cardiovascular risk in early Rheumatoid Arthritis, besides controlling disease activity...
August 2013: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/24778497/recurrent-subcutaneous-emphysema-in-a-treated-pulmonary-tuberculosis-patient-is-there-any-association
#11
Tony Ete, Sumantro Mondal, Debanjali Sinha, Arijit Nag, Atanu Chakraborty, Jyotirmoy Pal, Alakendu Ghosh
No abstract text is available yet for this article.
April 2014: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/24718487/correlation-of-oxidant-status-with-oxidative-tissue-damage-in-patients-with-rheumatoid-arthritis
#12
Suhana Datta, Sunanda Kundu, Parasar Ghosh, Soumita De, Alakendu Ghosh, Mitali Chatterjee
Rheumatoid arthritis (RA) is a debilitating autoimmune disease whose etiology remains unknown, but studies have consistently implicated a plethora of inflammatory mechanisms culminating in chronic symmetric and erosive synovitis. Importantly, reactive oxygen species (ROS) have been attributed to directly contribute towards the destructive, proliferative synovitis evident in RA. Accordingly, this study aimed to establish whether the degree of oxidative stress and disease activity score (DAS28) correlated with the downstream effects of oxidative damage...
November 2014: Clinical Rheumatology
https://www.readbyqxmd.com/read/24471255/a-foe-incognito-an-interesting-case-of-pleurisy
#13
R P Goswami, K Mukherjee, S Mondal, S Basu, P S Karmarkar, Alakendu Ghosh
Though pleuritis and pleural effusion are common in lupus patients they are distinctly rare as the initial manifestation of lupus. Diagnosis of lupus pleuritis is also a difficult task and often costly and lengthy immunological panels are employed to diagnose it. We report one case of systemic lupus erythematosus (SLE) presenting with lupus pleuritis as the first manifestation. We propose that demonstration LE cells have a very prominent role in differentiating lupus pleuritis from other causes of pleural effusions in SLE patients...
February 2013: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/24471254/sudden-onset-quadriparesis-after-minor-injury-to-neck-in-a-male-with-os-odontoideum
#14
P S Karmakar, P S Karmakar, Ritobrata Mitra, Subrata Basu, Alakendu Ghosh
Os odontoideum is a rare anomaly of the second cervical vertebra. Here, a young male patient with quadriparesis secondary to myelopathy associated with os odontoideum is reported. The patient was totally asymptomatic prior to this episode which was precipitated by trivial neck injury. He started recovering with conservative measures and was referred to our neurosurgery department for further evaluation and definitive surgical intervention as there is always a chance of recurrence of symptoms in these patients...
February 2013: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/24470658/cutaneous-manifestations-of-mixed-connective-tissue-disease-study-from-a-tertiary-care-hospital-in-eastern-india
#15
Sumit Sen, Pradyot Sinhamahapatra, Supriyo Choudhury, Anusree Gangopadhyay, Sanchaita Bala, Geetabali Sircar, Gobinda Chatterjee, Alakendu Ghosh
CONTEXT: Mixed connective tissue disorder is an uncommon disease. Some scientists are reluctant to recognize it as a separate entity. Some others have defined this ailment. Cutaneous features of this condition are unique. Researchers from India have described these features to relate to those described in the studies from other parts of the globe. AIMS: This study aims to delineate the skin manifestations of clearly defined mixed connective tissue disease (MCTD) patients, to compare them with those established as overlap syndrome, and to relate them with studies from other parts of the globe...
January 2014: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/24347862/unilateral-sternocostoclavicular-hyperostosis-in-a-patient-with-ankylosing-spondylitis-a-case-report-with-color-doppler-ultrasonogram-findings
#16
Sumantro Mondal, Debanjali Sinha, Arijit Nag, Alakendu Ghosh
Sternocostoclavicular hyperostosis is a chronic inflammatory disorder affecting the sternoclavicular joint and upper ribs. There is a strong association with seronegative spondyloarthropathy in which bilateral involvement is common. Ultrasonography and Color Doppler findings of this entity have not been described previously, to the best of our knowledge. We describe the findings in a patient of ankylosing spondylitis who was referred for unilateral sternoclavicular joint swelling.
July 2013: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/24326766/bedside-utility-of-clinical-scoring-systems-in-classifying-stroke
#17
COMPARATIVE STUDY
Rudra Prosad Goswami, Partha Sarathi Karmakar, Alakendu Ghosh
BACKGROUND: The study aimed to validate and compare the Siriraj score, Guy's hospital score, Greek score, and Besson score in a group of stroke patients. MATERIALS AND METHODS: We assessed the stroke scores and compared them to computed tomography (CT) scan of brain. RESULTS: Two hundred stroke patients (129 ischemic stroke) were included. For ischemic stroke, sensitivity and specificity were 71% and 92% (Siriraj score), 73% and 98% (Greek score), 59% and 87% (Guy's hospital score), and 65% and 98% (Besson score), respectively...
May 2013: Indian Journal of Medical Sciences
https://www.readbyqxmd.com/read/24220086/reversible-myelopathy-in-plasmodium-vivax-malaria-report-of-a-case-and-review-of-literature
#18
REVIEW
Rudra P Goswami, Rama P Goswami, Sumantro Mondal, Debanjali Sinha, Swati Mandal, Rajib Mondal, Animesh Dev, Jyotirmoy Pal, Alakendu Ghosh
No abstract text is available yet for this article.
September 2013: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/24014648/development-of-a-colour-doppler-ultrasound-scoring-system-in-patients-of-takayasu-s-arteritis-and-its-correlation-with-clinical-activity-score-itas-2010
#19
Debanjali Sinha, Sumantro Mondal, Arijit Nag, Alakendu Ghosh
OBJECTIVES: The objectives of this study were to develop a scoring system with colour Doppler ultrasound (CDUS) in patients with Takayasu's arteritis, to correlate the CDUS score with the Indian Takayasu's Activity Score (ITAS) and to assess the degree of agreement between CDUS and angiogram in the diagnosis of Takayasu's arteritis. METHODS: Nineteen angiographically confirmed Takayasu's arteritis patients fulfilling three or more of the 1990 ACR criteria were evaluated...
December 2013: Rheumatology
https://www.readbyqxmd.com/read/23594468/development-and-initial-validation-of-the-indian-takayasu-clinical-activity-score-itas2010
#20
MULTICENTER STUDY
Ramnath Misra, Debashish Danda, Sivakumar M Rajappa, Alakendu Ghosh, Rajiva Gupta, Kurugodu M Mahendranath, Lakshmanan Jeyaseelan, Able Lawrence, Paul A Bacon
OBJECTIVES: There are no valid instruments to measure disease activity in Takayasu arteritis (TA). We aim to provide a valid measure to assess clinical disease activity with or without incorporating acute phase reactants. METHODS: The Indian Takayasu Clinical Activity Score (ITAS) was initially derived from disease manifestations scored in the Disease Extent Index (DEI.Tak). The ITAS was validated by a group of physicians scoring both live and paper cases for inter-rater reliability (IRR), convergence with BVAS, correlation with the Physician's Global Assessment (PGA) and ESR/CRP...
October 2013: Rheumatology
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