keyword
https://read.qxmd.com/read/38478523/spatial-resolution-of-hiv-1-post-entry-steps-in-resting-cd4-t%C3%A2-cells
#21
JOURNAL ARTICLE
Swetha Ananth, Ina Ambiel, Sandra Schifferdecker, Thorsten G Müller, Paul R Wratil, Ernesto Mejias-Perez, Hans-Georg Kräusslich, Barbara Müller, Oliver T Keppler, Oliver T Fackler
Resting CD4 T cells resist productive HIV-1 infection. The HIV-2/simian immunodeficiency virus protein viral accessory protein X (Vpx) renders these cells permissive to infection, presumably by alleviating blocks at cytoplasmic reverse transcription and subsequent nuclear import of reverse-transcription/pre-integration complexes (RTC/PICs). Here, spatial analyses using quantitative virus imaging techniques reveal that HIV-1 capsids containing RTC/PICs are readily imported into the nucleus, recruit the host dependency factor CPSF6, and translocate to nuclear speckles in resting CD4 T cells...
March 12, 2024: Cell Reports
https://read.qxmd.com/read/38476451/postintensive-care-syndrome-family-a-comprehensive-review
#22
REVIEW
Kasumi Shirasaki, Toru Hifumi, Nobuto Nakanishi, Nobuyuki Nosaka, Kyohei Miyamoto, Miyuki H Komachi, Junpei Haruna, Shigeaki Inoue, Norio Otani
Families of critically ill patients are predisposed to tremendous burdens when their relatives are admitted to the intensive care unit (ICU). Postintensive care syndrome family (PICS-F) can be described as a devastated life, encompassing psychological, physical, and socioeconomical burdens that begin with the emotional impact experienced by the family when the patient is admitted to the ICU. PICS-F was primarily proposed as a clinically significant psychological impairment, but it needs to be extended beyond the psychological impairment of the family to include physical and socioeconomical impairments in the future...
2024: Acute Medicine & Surgery
https://read.qxmd.com/read/38474468/in-silico-investigations-on-the-synergistic-binding-mechanism-of-functional-compounds-with-beta-lactoglobulin
#23
JOURNAL ARTICLE
Tong Meng, Zhiguo Wang, Hao Zhang, Zhen Zhao, Wanlin Huang, Liucheng Xu, Min Liu, Jun Li, Hui Yan
Piceatannol (PIC) and epigallocatechin gallate (EGCG) are polyphenolic compounds with applications in the treatment of various diseases such as cancer, but their stability is poor. β-lactoglobulin (β-LG) is a natural carrier that provides a protective effect to small molecule compounds and thus improves their stability. To elucidate the mechanism of action of EGCG, PIC, and palmitate (PLM) in binding to β-LG individually and jointly, this study applied molecular docking and molecular dynamics simulations combined with in-depth analyses including noncovalent interaction (NCI) and binding free energy to investigate the binding characteristics between β-LG and compounds of PIC, EGCG, and PLM...
February 22, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38473952/integrated-discriminant-evaluation-of-molecular-genetic-markers-and-genetic-diversity-parameters-of-endangered-balearic-dog-breeds
#24
JOURNAL ARTICLE
José Manuel Alanzor Puente, Águeda Laura Pons Barro, Antonio González Ariza, María Del Amparo Martínez Martínez, Juan Vicente Delgado Bermejo, Francisco Javier Navas González
The genetic diversity analysis of six dog breeds, including Ca de Bestiar (CB), Ca de Bou (CBOU), Podenco Ibicenco (PI), Ca Rater (CR), Ca Mè (CM), and Ca de Conills (CC), reveals insightful findings. CB showcases the highest mean number of alleles (6.17) and heterozygosity values, with significant deviations from Hardy-Weinberg equilibrium (HWE) observed in five markers, indicating high intra-racial genetic diversity (average observed heterozygosity (Ho ) = 0.754, expected heterozygosity (He ) = 0.761)...
February 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473051/identifying-relationships-between-glutathione-s-transferase-2-single-nucleotide-polymorphisms-and-hypoxia-tolerance-and-growth-traits-in-macrobrachium-nipponense
#25
JOURNAL ARTICLE
Xuanbin Gao, Zijian Gao, Minglei Zhang, Hui Qiao, Sufei Jiang, Wenyi Zhang, Yiwei Xiong, Shubo Jin, Hongtuo Fu
Investigating hypoxia tolerance and growth trait single nucleotide polymorphisms (SNPs) in Macrobrachium nipponense is conducive to cultivating prawns with hypoxia tolerance and good growth characteristics. The glutathione S-transferase-2 gene ( GST-2 ) has been shown to regulate hypoxia responses in M. nipponense . In this study, we identified a single GST-2 SNP in M. nipponense , and analyzed its regulatory relationship with hypoxia tolerance and growth. The GST-2 sequence was amplified with a polymerase chain reaction from 197 "Taihu Lake No...
February 20, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38472873/hermetic-bags-a-short-term-solution-to-preserve-high-moisture-maize-during-grain-drying
#26
JOURNAL ARTICLE
Nileshwari Raju Yewle, Richard L Stroshine, R P Kingsly Ambrose, Dieudonne Baributsa
Maintaining maize quality while drying during a rainy season is a major challenge for smallholder farmers in developing countries. We conducted a study to evaluate the impact of temporarily storing wet maize of 18, 21, and 24% moisture content (m.c.) in hermetic Purdue Improved Crop Storage (PICS) and polypropylene (PP) woven (control) bags for 21 days. Oxygen and carbon dioxide concentrations were monitored, and m.c., germination, and visual mold were assessed. In PICS bags, oxygen dropped below 1% within 7, 11...
February 29, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38470897/virulence-genes-antimicrobial-resistance-profile-phylotyping-and-pathotyping-of-diarrheagenic-escherichia-coli-isolated-from-children-in-southwest-mexico
#27
JOURNAL ARTICLE
Gabriela Tapia-Pastrana, Metztli Rojas-Bautista, Pilar Hernández-Pérez, Olegario Santiago-Martínez, Lucía C Gómez-Rodríguez, Víctor M Terrazas-Luna, Jacobo Montes-Yedra, Alfonso A Bautista-Avendaño, Eduardo S García-López, Nidia Leon-Sicairos, Uriel A Angulo-Zamudio, Adrian Canizalez-Roman
Diarrheagenic E. coli (DEC) strains are one of the most important etiology factors causing diarrhea in children worldwide, especially in developing countries. DEC strains have characteristic virulence factors; however, other supplemental virulence genes (SVG) may contribute to the development of diarrhea in children. Therefore, this study aimed to determine the prevalence of DEC in children with diarrhea in southwestern Mexico and to associate childhood symptoms, SVG, and pathotypes with diarrhea-causing DEC strains...
2024: PloS One
https://read.qxmd.com/read/38464115/voluntary-co-contraction-of-ankle-muscles-alters-motor-unit-discharge-characteristics-and-reduces-estimates-of-persistent-inward-currents
#28
Matheus M Gomes, Sophia T Jenz, James A Beauchamp, Francesco Negro, C J Heckman, Gregory E P Pearcey
UNLABELLED: Motoneuronal persistent inward currents (PICs) are both facilitated by neuromodulatory inputs and highly sensitive to local inhibitory circuits (e.g., Ia reciprocal inhibition). Methods aimed to increase group Ia reciprocal inhibition from the antagonistic muscle have been successful in decreasing PICs, and the diffuse actions of neuromodulators released during activation of remote muscles have increased PICs. However, it remains unknown how motoneurons function in the presence of simultaneous excitatory and inhibitory commands...
March 3, 2024: bioRxiv
https://read.qxmd.com/read/38461205/a-deep-learning-method-for-empirical-spectral-prediction-and-inverse-design-of-all-optical-nonlinear-plasmonic-ring-resonator-switches
#29
JOURNAL ARTICLE
Ehsan Adibnia, Mohammad Ali Mansouri-Birjandi, Majid Ghadrdan, Pouria Jafari
All-optical plasmonic switches (AOPSs) utilizing surface plasmon polaritons are well-suited for integration into photonic integrated circuits (PICs) and play a crucial role in advancing all-optical signal processing. The current AOPS design methods still rely on trial-and-error or empirical approaches. In contrast, recent deep learning (DL) advances have proven highly effective as computational tools, offering an alternative means to accelerate nanophotonics simulations. This paper proposes an innovative approach utilizing DL for spectrum prediction and inverse design of AOPS...
March 9, 2024: Scientific Reports
https://read.qxmd.com/read/38453468/insula-amygdala-and-insula-thalamus-pathways-are-involved-in-comorbid-chronic-pain-and-depression-like-behavior-in-mice
#30
JOURNAL ARTICLE
Jing Chen, Yuan Gao, Shu-Ting Bao, Ying-Di Wang, Tao Jia, Cui Yin, Cheng Xiao, Chunyi Zhou
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment of either one because they exacerbate each other with unknown mechanisms. As the posterior insular cortex (PIC) integrates multiple somatosensory and emotional information and is implicated in either chronic pain or depression, we hypothesize that the PIC and its projections may contribute to the pathophysiology of comorbid chronic pain and depression. We show that PIC neurons were readily activated by mechanical, thermal, aversive, and stressful and appetitive stimulation in naïve and neuropathic pain male mice subjected to spared nerve injury (SNI)...
March 7, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38450296/incidence-of-mental-health-conditions-following-pediatric-hospital-admissions-analysis-of-a-national-database
#31
JOURNAL ARTICLE
Hannah R Daughtrey, Monica O Ruiz, Nicole Felix, Olga Saynina, Lee M Sanders, Kanwaljeet J S Anand
INTRODUCTION: Despite increasing survival of children following hospitalization, hospitalization may increase iatrogenic risk for mental health (MH) disorders, including acute stress, post-traumatic stress, anxiety, or depression. Using a population-based retrospective cohort study, we assessed the rates of new MH diagnoses during the 12 months after hospitalization, including the moderating effects of ICU exposure. STUDY DESIGN/METHODS: This was a retrospective case control study using the Truven Health Analytics insurance database...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38445738/electron-impact-partial-ionization-cross-sections-r-carvone-2-butanol-imidazole-and-2-nitroimidazole
#32
JOURNAL ARTICLE
Suriyaprasanth Shanmugasundaram, Rounak Agrawal, Dhanoj Gupta
We calculate electron impact partial and total ionization cross sections of R-carvone (C10H14O), 2-butanol (C4H10O), imidazole (C3H4N2), and 2-nitroimidazole (C3H3N3O2). We have used the Binary Encounter Bethe (BEB) model to obtain total electron impact ionization cross sections (TICSs). The modified BEB method in combination with mass spectrum data of the molecules is used to calculate the partial ionization cross section (PICS) of the cationic fragments dissociating from the parent molecule. Our PICS data for R-carvone and 2-butanol are in good agreement with the experimental data for all the cation fragments along with the TICS data...
March 7, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38443245/influence-of-connected-and-nonconnected-calibrated-frameworks-on-the-accuracy-of-complete-arch-implant-scans-obtained-by-using-four-intraoral-scanners-a-desktop-scanner-and-a-photogrammetry-system
#33
JOURNAL ARTICLE
Marta Revilla-León, Abdul B Barmak, Alejandro Lanis, John C Kois
STATEMENT OF PROBLEM: Different techniques have been proposed for increasing the accuracy of complete arch implant scans obtained by using intraoral scanners (IOSs), including a calibrated metal framework (IOSFix); however, its accuracy remains uncertain. PURPOSE: The purpose of this in vitro study was to compare the accuracy of complete arch scans obtained with connecting and non-connecting the implant scan bodies (ISBs) recorded using intraoral scanners (IOSs), a laboratory scanner (LBS), and photogrammetry (PG)...
March 4, 2024: Journal of Prosthetic Dentistry
https://read.qxmd.com/read/38441134/anticipating-icu-discharge-and-long-term-follow-up
#34
JOURNAL ARTICLE
Regis Goulart Rosa, Cassiano Teixeira, Simone Piva, Alessandro Morandi
PURPOSE OF REVIEW: This review aims to summarize recent literature findings on long-term outcomes following critical illness and to highlight potential strategies for preventing and managing health deterioration in survivors of critical care. RECENT FINDINGS: A substantial number of critical care survivors experience new or exacerbated impairments in their physical, cognitive or mental health, commonly named as postintensive care syndrome (PICS). Furthermore, those who survive critical illness often face an elevated risk of adverse outcomes in the months following their hospital stay, including infections, cardiovascular events, rehospitalizations and increased mortality...
April 1, 2024: Current Opinion in Critical Care
https://read.qxmd.com/read/38439445/extracting-causal-impulse-responses-from-baseband-band-limited-s-parameters-of-passive-photonic-integrated-circuits-for-time-domain-simulations
#35
JOURNAL ARTICLE
Jiajun Feng, Fusheng Zhao, Yinghao Ye
The dispersive characteristics and wavelength-dependent behaviors of passive photonic integrated circuits (PICs) can be well described by S-parameters. However, circuit-level simulations of PICs that commonly consist of both passive and active components have to be conducted in the time domain. Thus, S-parameters need to be converted into a time-domain representation without losing accuracy and violating physical properties (e.g., causality). To address this issue, this paper proposes an approach for extracting causal impulse responses of passive PICs by extrapolating their baseband band-limited S-parameters...
February 26, 2024: Optics Express
https://read.qxmd.com/read/38439436/atom-based-optical-polarization-modulator
#36
JOURNAL ARTICLE
Ruiqi Wang, Peiyu Yang, Ding Huang, Guzhi Bao, Weiping Zhang
In this work, we employ 87 Rb atoms as rotation media to manipulate the polarization of optical fields in both magnetic and magnetic-free environments. Employing the nonlinear magneto-optical rotation mechanism, we achieve a state-of-the-art magneto-optical rotation coefficient of 1.74×108 rad⋅T-1 ⋅m-1 which is four orders of magnitude higher than commonly employed materials. Additionally, in a magnetic-free environment, we achieve all-optical cross-polarization modulation between the pump and probe light via Rb atoms...
February 26, 2024: Optics Express
https://read.qxmd.com/read/38439290/absorption-and-scattering-limits-of-silicon-nitride-integrated-photonics-in-the-visible-spectrum
#37
JOURNAL ARTICLE
Mateus Corato-Zanarella, Xingchen Ji, Aseema Mohanty, Michal Lipson
Visible-light photonic integrated circuits (PICs) promise scalability for technologies such as quantum information, biosensing, and scanning displays, yet extending large-scale silicon photonics to shorter wavelengths has been challenging due to the higher losses. Silicon nitride (SiN) has stood out as the leading platform for visible photonics, but the propagation losses strongly depend on the film's deposition and fabrication processes. Current loss measurement techniques cannot accurately distinguish between absorption and surface scattering, making it difficult to identify the dominant loss source and reach the platform's fundamental limit...
February 12, 2024: Optics Express
https://read.qxmd.com/read/38439249/generation-of-ultra-intense-vortex-laser-from-a-binary-phase-square-spiral-zone-plate
#38
JOURNAL ARTICLE
Lingyu Zhang, Hao Zhang, Hongtao Huang, Jingyi Wang, Hongyu Zhou, Tongpu Yu
With the development of ultra-intense laser technology, the manipulation of relativistic laser pulses has become progressively challenging due to the limitations of damage thresholds for traditional optical devices. In recent years, the generation and manipulation of ultra-intense vortex laser pulses by plasma has attracted a great deal of attention. Here, we propose a new scheme to produce a relativistic vortex laser. This is achieved by using a relativistic Gaussian drive laser to irradiate a plasma binary phase square spiral zone plate (BPSSZP)...
February 12, 2024: Optics Express
https://read.qxmd.com/read/38434252/post-intensive-cardiac-care-outpatient-long-term-outreach-clinic-piccolo-clinic-defining-health-care-needs-and-outcomes-among-coronary-care-unit-survivors
#39
JOURNAL ARTICLE
Christopher K Mason, Sara K Adie, Michael J Shea, Matthew C Konerman, Michael P Thomas, Jakob I McSparron, Theodore J Iwashyna, Hallie C Prescott, Andrea D Thompson
OBJECTIVE: Patients who survive critical illness endure complex physical and mental health conditions, referred to as post-intensive care syndrome (PICS). The University of Michigan's post-intensive cardiac care outpatient long-term outreach (PICCOLO) clinic is designed for patients recently admitted to the coronary care unit (CCU). The long-term goal of this clinic is to understand post-CCU patients' needs and design targeted interventions to reduce their morbidity and mortality post-discharge...
February 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38431628/influence-of-alveolar-bone-thickness-and-bucco-palatal-inclination-on-root-resorption-of-lateral-incisors-in-unilateral-maxillary-impacted-canines-a-retrospective-observational-study
#40
JOURNAL ARTICLE
Weiman Sun, Yuanyuan Yang, Chenghuan Liu, Houxuan Li, Lang Lei
BACKGROUND: This study aimed to investigate the potential associations between alveolar bone thickness, bucco-palatal inclination of maxillary lateral incisors, and lateral incisor root resorption in patients with unilateral maxillary impacted canines (UMICs). METHODS: A total of three hundred and five subjects (120 males, 185 females; mean age, 16.39 years; standard deviation, 4.04) with UMICs were included. Canine position and root resorption were assessed using CBCT...
March 2, 2024: BMC Oral Health
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