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https://www.readbyqxmd.com/read/29156589/genome-wide-development-of-microrna-based-ssr-markers-in-medicago-truncatula-with-their-transferability-analysis-and-utilization-in-related-legume-species
#1
Xueyang Min, Zhengshe Zhang, Yisong Liu, Xingyi Wei, Zhipeng Liu, Yanrong Wang, Wenxian Liu
Microsatellite (simple sequence repeats, SSRs) marker is one of the most widely used markers in marker-assisted breeding. As one type of functional markers, MicroRNA-based SSR (miRNA-SSR) markers have been exploited mainly in animals, but the development and characterization of miRNA-SSR markers in plants are still limited. In the present study, miRNA-SSR markers for Medicago truncatula (M. truncatula) were developed and their cross-species transferability in six leguminous species was evaluated. A total of 169 primer pairs were successfully designed from 130 M...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29147775/dft-tddft-computational-study-of-the-structural-electronic-and-optical-properties-of-rhodium-iii-and-iridium-iii-complexes-based-on-tris-picolinate-bidentate-ligands
#2
Houari Brahim, Boumediene Haddad, Sefia Brahim, Abdelkrim Guendouzi
The electronic structures and spectroscopic properties of two complexes [M(pic)3] (M = Ir, Rh) containing picolinate as bidentate ligands have been calculated by means density functional theory (DFT) and time-dependent DFT/TD-DFT using three hybrid functionals B3LYP, PBE0 and mPW1PW91. The PBE0 and mPW1PW91 functionals, which have the same HF exchange fraction (25%), give similar results and do not differ drastically from B3LYP results. Calculated geometric parameters of the complexes are in good agreement with the available experimental data...
November 17, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29147098/purification-and-anti-pathogenic-properties-of-immunoglobulin-concentrates-from-porcine-blood
#3
Tae-Hwan Jung, Jae-Hwan Choi, Kyung-Chul Koh, Woo-Min Jeon, Kyoung-Sik Han
During slaughtering, animal blood is typically discarded, resulting in water pollution. However, this discarded blood has valuable components, such as immunoglobulin (Ig). Although several studies have been conducted to develop methods for effective recycling of slaughterhouse blood, they have not been commercially utilized in Korea. Here, we extracted an Ig-rich fraction from porcine blood that was then subjected to various in vitro tests, including pathogen growth inhibition, antigenic cross-reactivity, and anti-toxin activity...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29144136/photophysics-of-j-aggregate-mediated-energy-transfer-on-dna
#4
James L Banal, Toru Kondo, Rémi Veneziano, Mark Bathe, Gabriela S Schlau-Cohen
Achieving nanoscale spatial and electronic control over the formation of dye aggregates is a major synthetic challenge due to their typically inhomogeneous self-assembly, which limits control over their higher-order organization. To address these challenges, synthetic DNA-templated pseudoisocyanine (PIC) J-aggregates were recently introduced. However, the dependence of the photophysics of the superradiant exciton on the underlying DNA template length and the impact of static disorder on energy transfer through these PIC J-aggregates remain unknown...
November 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29143938/short-hairpin-rna-interference-targeting-interleukin-1-receptor-type-i-in-the-paraventricular-nucleus-attenuates-hypertension-in-rats
#5
Peng Lu, Shu-Jun Jiang, Hong Pan, Ai-Li Xu, Gui-Hua Wang, Chun-Lei Ma, Zhen Shi
Blood pressure is controlled by tonic sympathetic activities, excessive activation of which contributes to the pathogenesis and progression of hypertension. Interleukin (IL)-1β in the paraventricular nucleus (PVN) is involved in sympathetic overdrive and hypertension. Here, we investigated the therapeutic effects of IL-1 receptor type I (IL-1R1) gene silencing in the PVN on hypertension. Recombinant lentivirus vectors expressing a short hairpin RNA (shRNA) targeting IL-1R1 (Lv-shR-IL-1R1) or a control shRNA were microinjected into PVN of spontaneously hypertensive rats (SHRs) and normotensive WKY rats...
November 16, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29143703/dose-response-evaluation-of-the-standardized-ileal-digestible-tryptophan-lysine-ratio-to-maximize-growth-performance-of-growing-finishing-gilts-under-commercial-conditions
#6
M A D Gonçalves, M D Tokach, N M Bello, K J Touchette, R D Goodband, J M DeRouchey, J C Woodworth, S S Dritz
Environmental regulations as well as economic incentives have resulted in greater use of synthetic amino acids in swine diets. Tryptophan is typically the second limiting amino acid in corn-soybean meal-based diets. However, using corn-based co-products emphasizes the need to evaluate the pig's response to increasing Trp concentrations. Therefore, the objective of these studies was to evaluate the dose-response to increasing standardized ileal digestible (SID) Trp : Lys on growth performance of growing-finishing gilts housed under large-scale commercial conditions...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29143602/molecular-and-agro-morphological-characterization-of-ancient-wheat-landraces-of-turkey
#7
Kahraman Gurcan, Fatih Demirel, Mehmet Tekin, Serap Demirel, Taner Akar
BACKGROUND: Turkey is one of the important gene centers for many crop species. In this research, some ancient wheats such as tetraploid and diploid hulled wheats together with hexaploid tir wheats (Triticum aestivum ssp. leucospermum Korn.) landraces mainly adapted to harsh winter conditions of Eastern Anatolian region of Turkey were characterized at agro-morphological and molecular level. Totally 50 hulled wheat population from Kastamonu, Konya and Kayseri provinces and 15 tir wheats from Kars provinces of Turkey were in-situ collected for characterization in 2013...
November 14, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29141908/two-distinct-regulatory-mechanisms-of-transcriptional-initiation-in-response-to-nutrient-signaling
#8
Jannatul Ferdoush, Rwik Sen, Amala Kaja, Priyanka Barman, Sukesh R Bhaumik
SAGA (Spt-Ada-Gcn5-Acetyltransferase) and TFIID (transcription factor IID) have been previously shown to facilitate the PIC (pre-initiation complex) formation at the promoters of two distinct sets of genes. Here, we demonstrate that TFIID and SAGA differentially participate in stimulation of the PIC formation (and hence transcriptional initiation) at the promoter of PHO84, a gene for high affinity inorganic phosphate (Pi) transporter for crucial cellular functions, in response to nutrient signaling. We show that transcriptional initiation of PHO84 occurs predominantly in the TFIID-dependent manner in the absence of Pi in the growth medium...
November 15, 2017: Genetics
https://www.readbyqxmd.com/read/29141219/preventive-inhibition-of-liver-tumorigenesis-by-systemic-activation-of-innate-immune-functions
#9
Jin Lee, Rui Liao, Gaowei Wang, Bi-Huei Yang, Xiaolin Luo, Nissi M Varki, Shuang-Jian Qiu, Bing Ren, Wenxian Fu, Gen-Sheng Feng
Liver cancer has become the second most deadly malignant disease, with no efficient targeted or immune therapeutic agents available yet. While dissecting the roles of cytoplasmic signaling molecules in hepatocarcinogenesis using an inducible mouse gene targeting system, Mx1-cre, we identified a potent liver tumor-inhibitory effect of synthetic double-stranded RNA (dsRNA), polyinosinic-polycytidylic acid (pIC), an inducer of the Mx1-cre system. Injection of pIC at the pre-cancer stage robustly suppressed liver tumorigenesis either induced by chemical carcinogens or by Pten loss and associated hepatosteatosis...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29140713/direct-observation-of-plasmon-induced-interfacial-charge-separation-in-metal-semiconductor-hybrid-nanostructures-by-measuring-surface-potentials
#10
Seung-Hoon Lee, Seung Woo Lee, Taegon Oh, Sarah Hurst Petrosko, Chad A Mirkin, Jae-Won Jang
Plasmon-induced interfacial charge separation (PICS) is one of the key processes responsible for the improved conversion efficiencies of energy-harvesting devices that incorporate metal nanostructures. In this letter, we reveal a mechanism of PICS by visualizing (with nanometer-scale resolution) and characterizing plasmon-exciton coupling between p-type poly(pyrrole) (PPy) nanowires (NWs) and Ag nanoparticles (NPs) using light-irradiated Kelvin probe force microscopy (KPFM). Under blue-light irradiation, the Ag NPs are expected to donate electrons to the PPy NWs via a hot electron injection process...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29138206/monitor-ic-study-a-mixed-methods-prospective-multicentre-controlled-cohort-study-assessing-5-year-outcomes-of-icu-survivors-and-related-healthcare-costs-a-study-protocol
#11
Wytske Geense, Marieke Zegers, Hester Vermeulen, Mark van den Boogaard, Johannes van der Hoeven
INTRODUCTION: Due to advances in critical care medicine, more patients survive their critical illness. However, intensive care unit (ICU) survivors often experience long-term physical, cognitive and mental problems, summarised as post-intensive care syndrome (PICS), impacting their health-related quality of life (HRQoL). In what frequency PICS occurs, and to what extent this influences ICU survivors' HRQoL, is mostly unknown. The aims of this study are therefore to study the: (1) 5-year patient outcomes, (2) predictors for PICS, (3) ratio between HRQoL of ICU survivors and healthcare-related costs, and (4) care and support needs...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137161/constructing-asymmetric-polyion-complex-vesicles-via-template-assembling-strategy-formulation-control-and-tunable-permeability
#12
Junbo Li, Lijuan Liang, Ju Liang, Wenlan Wu, Huiyun Zhou, Jinwu Guo
A strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b-PNIPAm-@-Au NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2-methacryloyloxy propylimidazolium bromine)] (PEG-b-PMMPImB) via polyion complex of PMMA and PMMPImB. After removing the Au NPs template, asymmetric PICsomes composed of a PNIPAm inner-shell, PIC wall, and PEG outer-corona were obtained...
November 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29120386/high-quality-unigenes-and-microsatellite-markers-from-tissue-specific-transcriptome-and-development-of-a-database-in-clusterbean-cyamopsis-tetragonoloba-l-taub
#13
Hukam C Rawal, Shrawan Kumar, Amitha Mithra S V, Amolkumar U Solanke, Deepti Nigam, Swati Saxena, Anshika Tyagi, Sureshkumar V, Neelam R Yadav, Pritam Kalia, Narendra Pratap Singh, Nagendra Kumar Singh, Tilak Raj Sharma, Kishor Gaikwad
Clusterbean (Cyamopsis tetragonoloba L. Taub), is an important industrial, vegetable and forage crop. This crop owes its commercial importance to the presence of guar gum (galactomannans) in its endosperm which is used as a lubricant in a range of industries. Despite its relevance to agriculture and industry, genomic resources available in this crop are limited. Therefore, the present study was undertaken to generate RNA-Seq based transcriptome from leaf, shoot, and flower tissues. A total of 145 million high quality Illumina reads were assembled using Trinity into 127,706 transcripts and 48,007 non-redundant high quality (HQ) unigenes...
November 9, 2017: Genes
https://www.readbyqxmd.com/read/29116449/comparative-pulvinar-organization-across-different-primate-species
#14
Ricardo Gattass, Juliana G M Soares, Bruss Lima
In this chapter, we compare the pattern of pulvinar immunohistochemical staining for the calcium-binding proteins calbindin and parvalbumin and for the neurofilament protein SMI-32 in macaque, capuchin, and squirrel monkeys. This group of New and Old World primates shares five similar pulvinar subdivisions: PIP, PIM, PIC, PIL, and PILS. In the Old World macaque monkey, the inferior-lateral pulvinar can be subdivided into the P1 and P2 fields based on its connectivity with visual area V1. On the other hand, only the P1 field and no P2 was found in the New World capuchin monkey...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29115917/the-complete-chloroplast-genome-of-primulina-and-two-novel-strategies-for-development-of-high-polymorphic-loci-for-population-genetic-and-phylogenetic-studies
#15
Chao Feng, Meizhen Xu, Chen Feng, Eric J B von Wettberg, Ming Kang
BACKGROUND: Primulina Hance is an emerging model for studying evolutionary divergence, adaptation and speciation of the karst flora. However, phylogenetic relationships within the genus have not been resolved due to low variation detected in the cpDNA regions. Chloroplast genomes can provide important information for phylogenetic and population genetic studies. Recent advances in next-generation sequencing (NGS) techniques greatly facilitate sequencing whole chloroplast genomes for multiple individuals...
November 7, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29115911/leveraging-social-media-in-the-stem-cell-sector-exploring-twitter-s-potential-as-a-vehicle-for-public-information-campaigns
#16
Kathleen McNutt, Amy Zarzeczny
AIM: Our aim in this project was to explore Twitter's potential as a vehicle for an online public information campaign (PIC) focused on providing evidence-based information about stem cell therapies and the market for unproven stem cell-based interventions. METHODS: We designed an online, Twitter-based PIC using classic design principles and identified a set of target intermediaries (organizations with online influence) using a network governance approach. We tracked the PIC's dissemination over a 2-month period, and evaluated it using metrics from the #SMMStandards Conclave...
November 8, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29112375/gold-polar-intermetallics-structural-versatility-through-exclusive-bonding-motifs
#17
Volodymyr Smetana, Melissa Rhodehouse, Gerd Meyer, Anja-Verena Mudring
The design of new materials with desired chemical and physical characteristics requires thorough understanding of the underlying composition-structure-property relationships and the experimental possibility of their modification through the controlled involvement of new components. From this point of view, intermetallic phases, a class of compounds formed by two or more metals, present an endless field of combinations that produce several chemical compound classes ranging from simple alloys to true ionic compounds...
November 7, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29110988/resveratrol-analogues-like-piceatannol-are-potent-antioxidants-as-quantitatively-demonstrated-through-the-high-scavenging-ability-against-reactive-oxygen-species-and-methyl-radical
#18
Yoshimi Sueishi, Risako Nii, Naru Kakizaki
Resveratrol (RSV) analogues have attracted much attention because of the expected health functions including antioxidant activities. We have carried out a quantitative determination of the scavenging abilities of six trans-RSV analogues against various reactive oxygen species and methyl radical (hydroxyl radical, superoxide, alkoxyl radical, peroxyl radical, methyl radical, and singlet oxygen). RSV analogues are in general more potent scavenger than the parent RSV. Furthermore, piceatannol (PIC) having two OH groups in the ortho position of resveratrol was found to show 11 times higher scavenging ability against peroxyl radical than parent resveratrol...
October 20, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29109520/a-perfusion-incubator-liver-chip-for-3d-cell-culture-with-application-on-chronic-hepatotoxicity-testing
#19
Fang Yu, Rensheng Deng, Wen Hao Tong, Li Huan, Ng Chan Way, Anik IslamBadhan, Ciprian Iliescu, Hanry Yu
Liver chips have been developed to recapitulate in vivo physiological conditions to enhance hepatocyte functions for assessing acute responses to drugs. To develop liver chips that can assess repeated dosing chronic hepatotoxicity, we need to ensure that hepatocyte functions be maintained at constant values over two weeks in stable culture conditions of sterility, temperature, pH, fluidic-flow of culture media and drugs. We have designed a perfusion-incubator-liver-chip (PIC) for 3D cell culture, that assures a tangential flow of the media over the spheroids culture...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108536/-post-intensive-care-syndrome
#20
EDITORIAL
Tilde Skovkær Withen Olesen, Mary Kruse, Malgorzata Pawlowicz-Dworzanska, Kirsten Klostergaard, Peter Derek Christian Leutscher
Patients surviving severe critical illness commonly develop post intensive care syndrome (PICS). The syndrome consists of a constellation of cognitive dysfunction, depression, anxiety and post-traumatic stress disorder combined with physical weakness. Different contributing risk factors for development of PICS have been identified. Furthermore, close family members of the patient are at risk of developing similar psychiatric manifestations. Focus should be on early preventive measures during hospitalization and post-ICU follow-up with a multidisciplinary approach...
November 6, 2017: Ugeskrift for Laeger
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