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https://www.readbyqxmd.com/read/29338582/a-human-pericardium-biopolymeric-scaffold-for-autologous-heart-valve-tissue-engineering-cellular-and-extracellular-matrix-structure-and-biomechanical-properties-in-comparison-with-a-normal-aortic-heart-valve
#1
Frantisek Straka, David Schornik, Jaroslav Masin, Elena Filova, Tomas Mirejovsky, Zuzana Burdikova, Zdenek Svindrych, Hynek Chlup, Lukas Horny, Matej Daniel, Jiri Machac, Jelena Skibová, Jan Pirk, Lucie Bacakova
The objective of our study was to compare the cellular and extracellular matrix (ECM) structure and the biomechanical properties of human pericardium (HP) with the normal human aortic heart valve (NAV). HP tissues (from 12 patients) and NAV samples (from 5 patients) were harvested during heart surgery. The main cells in HP were pericardial interstitial cells (PICs), which are fibroblast-like cells of mesenchymal origin similar to the valvular interstitial cells (VICs) in NAV tissue. The extracellular matrix (ECM) of HP had a statistically significantly (p ≤ 0...
January 17, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29334809/accidental-pharmacological-poisonings-in-young-children-population-based-study-in-three-settings
#2
Jane C Bell, Jason P Bentley, Catriona Downie, Rose Cairns, Nicholas A Buckley, Annette Katelaris, Sallie-Anne Pearson, Natasha Nassar
INTRODUCTION: Pharmacological poisonings in young children are avoidable. Previous studies report calls to poisons centres, presentations to emergency departments (ED) or hospital admissions. There are limited data assessing concurrent management of poisonings across all three settings. We aimed to describe accidental pharmacological poisonings in young children across our Poisons Information Centre (PIC), EDs and hospitals. METHODS: A population-based study in New South Wales, Australia, of PIC calls, ED presentations and hospital admissions for accidental pharmacological poisoning in children aged <5 years, 2007-2013...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29328202/inclined-emitting-slotted-single-mode-laser-with-1-7%C3%A2-vertical-divergence-angle-for-pic-applications
#3
Yejin Zhang, Yanmei Su, Yu Bi, Jiaoqing Pan, Hongyan Yu, Yang Zhang, Jie Sun, Xiuyan Sun, Ming Chong
In this Letter, a new type of single-mode slotted laser used for an on-chip light source in photonic integrated circuits is proposed. An inclined light beam with a low vertical divergence angle can be directly coupled into the surface grating of the silicon to form an integrated light source. Experimentally, a III-V laser with a 54.6° inclined angle and a vertical divergence angle of 1.7° is achieved by introducing a kind of specially distributed microstructure. The side mode suppression ratio is better than 45 dB, and the continuous wave output power reaches 6...
January 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29326330/program-of-integrated-care-for-patients-with-chronic-obstructive-pulmonary-disease-and-multiple-comorbidities-pic-copd-a-randomised-controlled-trial
#4
Louise Rose, Laura Istanboulian, Lise Carriere, Anna Thomas, Han-Byul Lee, Shaghayegh Rezaie, Roshan Shafai, Ian Fraser
We sought to evaluate the effectiveness of a multi-component, case manager-led exacerbation prevention/management model for reducing emergency department visits. Secondary outcomes included hospitalisation, mortality, health-related quality of life, chronic obstructive pulmonary disease (COPD) severity, COPD self-efficacy, anxiety and depression.Two-centre randomised controlled trial recruiting patients with ≥2 prognostically important COPD-associated comorbidities. We compared our multi-component intervention including individualised care/action plans and telephone consults (12-weekly then 9-monthly) with usual care (both groups)...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29325832/the-pics-technique-a-novel-approach-for-residual-curvature-correction-during-penile-prosthesis-implantation-in-patients-with-severe-peyronie-s-disease-using-the-collagen-fleece-tachosil
#5
Georgios Hatzichristodoulou
BACKGROUND: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach. AIM: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA). METHODS: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally...
January 8, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29323761/chronic-critical-illness-application-of-what-we-know
#6
REVIEW
Martin D Rosenthal, Amir Y Kamel, Cameron M Rosenthal, Scott Brakenridge, Chasen A Croft, Frederick A Moore
Over the last decade, chronic critical illness (CCI) has emerged as an epidemic in intensive care unit (ICU) survivors worldwide. Advances in ICU technology and implementation of evidence-based care bundles have significantly decreased early deaths and have allowed patients to survive previously lethal multiple organ failure (MOF). Many MOF survivors, however, experience a persistent dysregulated immune response that is causing an increasingly predominant clinical phenotype called the persistent inflammation, immunosuppression, and catabolism syndrome (PICS)...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29319222/availability-of-paracetamol-sold-over-the-counter-in-europe-a-descriptive-cross-sectional-international-survey-of-pack-size-restriction
#7
Britt Reuter Morthorst, Annette Erlangsen, Merete Nordentoft, Keith Hawton, Lotte Christine Groth Hoegberg, Kim Peder Dalhoff
Due to the risk of hepatotoxicity when excessive amounts of paracetamol are consumed, Poisons Information Centers (PICs) frequently receive paracetamol-related enquiries. This study examined how widely pack size restrictions of paracetamol sold over-the-counter have been implemented in Europe and also availability of paracetamol through non-pharmacy outlets and their possible associations with frequency of poisoning enquiries. A cross-sectional European multicentre questionnaire study was performed using a questionnaire to identify the extent and nature of paracetamol pack size restrictions, non-pharmacy outlet sales and the frequency of paracetamol-related enquiries to PICs...
January 10, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29318469/numerical-simulation-of-ion-transport-in-a-nano-electrospray-ion-source-at-atmospheric-pressure
#8
Wei Wang, Steve Bajic, Benzi John, David R Emerson
Understanding ion transport properties from the ion source to the mass spectrometer (MS) is essential for optimizing device performance. Numerical simulation helps in understanding of ion transport properties and, furthermore, facilitates instrument design. In contrast to previously reported numerical studies, ion transport simulations in a continuous injection mode whilst considering realistic space-charge effects have been carried out. The flow field was solved using Reynolds-averaged Navier-Stokes (RANS) equations, and a particle-in-cell (PIC) method was applied to solve a time-dependent electric field with local charge density...
January 9, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29317284/just-a-quick-pic-ethics-of-medical-photography
#9
Tiana Kazemi, Kachiu C Lee, Lionel Bercovitch
No abstract text is available yet for this article.
January 6, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29316314/an-integrated-tool-for-microsatellite-isolation-and-validation-from-the-reference-genome-and-their-application-in-the-study-of-breeding-turnover-in-an-endangered-avian-population
#10
Xian Hou, Pengwei Xu, Zhenzhen Lin, Josephine d'URBAN-Jackson, Andrew Dixon, Batbayar Bold, Jiliang Xu, Xiangjiang Zhan
Accurate individual identification is required to estimate survival rates in avian populations. For endangered species, non-invasive methods of obtaining individual identification, such as using molted feathers as a source of DNA for microsatellite markers, are preferred because of less disturbance, easy sample preparation and high efficiency. With the availability of many avian genomes, a few pipelines isolating genome-wide microsatellites have been published, but it is still a challenge to isolate microsatellites from the reference genome efficiently...
January 9, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29312538/genome-wide-gene-expression-analysis-in-the-amphioxus-branchiostoma-belcheri-after-poly-i-c-challenge-using-strand-specific-rna-seq
#11
Qi-Lin Zhang, Zheng-Qing Xie, Ming-Zhong Liang, Bang Luo, Xiu-Qiang Wang, Jun-Yuan Chen
The gene expression associated with immune response to bacteria/bacterial mimic has been extensively analyzed in amphioxus, but remains largely unknown about how gene are involved in the immune response to viral invasion at expression level. Here, we analyze the rRNA-depleted transcriptomes of Branchiostoma belcheri using strand-specific RNA-seq in response to the viral mimic, poly (I:C) (pIC). A total of 5,317 differentially expressed genes were detected at treatment group by comparing with control. The gene with the most significant expression changes (top 15) after pIC challenge and 7 immune-related categories involving 58 differently expressed genes were scrutinized...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29304053/prior-exposure-to-corticosterone-markedly-enhances-and-prolongs-the-neuroinflammatory-response-to-systemic-challenge-with-lps
#12
Kimberly A Kelly, Lindsay T Michalovicz, Julie V Miller, Vincent Castranova, Diane B Miller, James P O'Callaghan
Systemic exposure to the inflammagen and bacterial endotoxin lipopolysaccharide (LPS) has been widely used to evaluate inflammation and sickness behavior. While many inflammatory conditions occur in the periphery, it is well established that peripheral inflammation can affect the brain. Neuroinflammation, the elaboration of proinflammatory mediators in the CNS, commonly is associated with behavioral symptoms (e.g., lethargy, anhedonia, anorexia, depression, etc.) termed sickness behavior. Stressors have been shown to interact with and alter neuroinflammatory responses and associated behaviors...
2018: PloS One
https://www.readbyqxmd.com/read/29301276/rosiglitazone-as-a-modulator-of-tlr4-and-tlr3-signaling-pathways-in-rat-primary-neurons-and-astrocytes
#13
Dmitry V Chistyakov, Nadezda V Azbukina, Alexandr V Lopachev, Ksenia N Kulichenkova, Alina A Astakhova, Marina G Sergeeva
An antidiabetic drug of the thiazolidinedione class, rosiglitazone (RG) demonstrates anti-inflammatory properties in various brain pathologies. The mechanism of RG action in brain cells is not fully known. To unravel mechanisms of RG modulation of toll-like receptor (TLR) signaling pathways, we compare primary rat neuron and astrocyte cultures stimulated with the TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist poly I:C (PIC). Both TLR agonists induced tumor necrosis factor (TNFα) release in astrocytes, but not in neurons...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29298541/chitosan-poly-lactic-acid-coated-piceatannol-nanoparticles-exert-an-in-vitro-apoptosis-activity-on-liver-lung-and-breast-cancer-cell-lines
#14
Jeevitha Dhanapal, Malathy Balaraman Ravindrran
The aim of the study was to synthesize nanoparticles (NPs) with chitosan (CS), and poly (lactic acid) (PLA) as a carrier for the drug piceatannol (PIC). The synthesized nanoparticles form the composite of polymeric-drug nanoparticles (CS/PLA-PIC NPs) by dropping method. The preliminary and stability studies were determined for the polymers drug-loading capacity and encapsulation efficiencies. The in vitro drug release study showed that NPs provided a continuous release of the entrapped PIC. The NPs found to be a good scavenger for DPPH, SOD and NO radicals...
January 3, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29296883/innate-transcriptional-effects-by-adjuvants-on-the-magnitude-quality-and-durability-of-hiv-envelope-responses-in-nhps
#15
Joseph R Francica, Daniel E Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L Yates, Bronwyn Gunn, Ennio De Gregorio, Barbara J Flynn, Nicholas M Valiante, Padma Malyala, Susan W Barnett, Pampi Sarkar, Manmohan Singh, Siddhartha Jain, Margaret Ackerman, Munir Alam, Guido Ferrari, Georgia D Tomaras, Derek T O'Hagan, Alan Aderem, Galit Alter, Robert A Seder
Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems serology, we assessed how distinct innate pathways altered HIV-specific antibody responses in nonhuman primates (NHPs) using 8 clinically based adjuvants. NHPs were immunized with a glycoprotein 140 HIV envelope protein (Env) and insoluble aluminum salts (alum), MF59, or adjuvant nanoemulsion (ANE) coformulated with or without Toll-like receptor 4 (TLR4) and 7 agonists...
November 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29288425/polymorphisms-of-caprine-gnrhr-gene-and-their-association-with-litter-size-in-west-african-dwarf-goats
#16
M N Bemji, A M Isa, E M Ibeagha-Awemu, M Wheto
Gonadotropin-releasing hormone receptor (GnRHR) gene is considered a candidate gene for litter size due to its critical role in regulating the activities of hypothalamo-pituitary-gonadal axis which synthesizes and releases gonadotropins. This study was designed to identify mutations within the caprine GnRHR gene and investigate their association with litter size at various parities. Polymorphisms scanning and genotyping of GnRHR gene in West African Dwarf (WAD) goats (n = 226) revealed three single nucleotide polymorphisms (SNPs), one mutation (g...
December 29, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/29280129/-preliminary-discussion-of-therapeutic-strategies-in-persistent-inflammation-immunosuppression-catabolism-syndrome
#17
Heyi Su, Zhenhui Guo
So far, there is still lack of effective treatment to control persistent inflammation immunosuppression catabolism syndrome (PICS) appeared generally in those chronic critical illnesses (CCI) patients, restricted by the development of medicine and scientific research nowadays. Because the uncontrolled PICS aggravates continuously, ICU stay of the CCI patients has been obviously prolonging and the late mortality elevates greatly. So exploring effective therapeutic strategies is obviously pressing. With the characteristics in PICS such as that elderly with sepsis or severe trauma tops the list of morbidity, progressing illness is difficult to intervent and various pathology changes occur simultaneously, the fundamental principle of treatment, "Focal screening, early control, joint intervention" must be followed...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29277171/post-intensive-care-syndrome-symptoms-and-health-related-quality-of-life-in-family-decision-makers-of-critically-ill-patients
#18
Amy B Petrinec, Bradley R Martin
OBJECTIVE: Family members of critically ill patients can suffer symptoms of post-intensive care syndrome-family (PICS-F), including anxiety, depression, and posttraumatic stress disorder (PTSD) with a diminished quality of life. Our aim was to examine the relationship between coping strategies used by family decision-makers (FDMs) of critically ill patients and the severity of PICS-F symptoms and to examine the relationship between FDM PICS-F symptoms and health-related quality of life (HRQOL)...
December 26, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29275088/genetic-analysis-of-southern-brazil-subjects-using-the-powerseq%C3%A2-auto-y-system-for-short-tandem-repeat-sequencing
#19
Deborah S B S Silva, Fernanda R Sawitzki, Melissa K R Scheible, Sarah F Bailey, Clarice S Alho, Seth A Faith
With the advent of Next-Generation Sequencing technology, sequencing of short tandem repeats (STRs) allows for a more detailed analysis when compared to size-based fragment methods (capillary electrophoresis-CE). The implementation of high-throughput sequencing can help uncover deeper genetic diversities of different populations. Subjects from the South region of Brazil present a particular and more homogeneous ancestry background when compared to other regions of the country. Both autosomal and Y- STRs have been analyzed in these individuals; however, all analyses published to date encompass data from CE-based fragment analysis...
December 16, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29273553/association-between-fasn-gene-polymorphisms-ultrasound-carcass-traits-and-intramuscular-fat-in-qinchuan-cattle
#20
Sayed Haidar Abbas Raza, Linsheng Gui, Rajwali Khan, Nicola M Schreurs, Wang Xiaoyu, Sen Wu, Chugang Mei, Li Wang, Xueyao Ma, Dawei Wei, Hongfang Guo, Song Zhang, Xingping Wang, Hubdar Ali Kaleri, Linsen Zan
Fatty acid synthase (FASN) is an enzyme involved with fat deposition and fatty acid composition in cattle. This study was conducted to detect single nucleotide polymorphisms (SNPs) of the FASN gene and explore their relationships with ultrasound carcass traits in order to assess the potential use of the FASN gene for the breeding selection of Qinchuan cattle for desirable carcass traits. The frequencies of SNP g.12740C>T, g.13192T>C and g.13232C>T were identified in 525 individual Qinchuan cattle which were also assessed for backfat depth, eye muscle area and intramuscular fat by ultrasound...
December 19, 2017: Gene
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