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https://www.readbyqxmd.com/read/28437962/rapidly-reconfigurable-high-fidelity-optical-arbitrary-waveform-generation-in-heterogeneous-photonic-integrated-circuits
#1
Shaoqi Feng, Chuan Qin, Kuanping Shang, Shibnath Pathak, Weicheng Lai, Binbin Guan, Matthew Clements, Tiehui Su, Guangyao Liu, Hongbo Lu, Ryan P Scott, S J Ben Yoo
This paper demonstrates rapidly reconfigurable, high-fidelity optical arbitrary waveform generation (OAWG) in a heterogeneous photonic integrated circuit (PIC). The heterogeneous PIC combines advantages of high-speed indium phosphide (InP) modulators and low-loss, high-contrast silicon nitride (Si<sub>3</sub>N<sub>4</sub>) arrayed waveguide gratings (AWGs) so that high-fidelity optical waveform syntheses with rapid waveform updates are possible. The generated optical waveforms spanned a 160 GHz spectral bandwidth starting from an optical frequency comb consisting of eight comb lines separated by 20 GHz channel spacing...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28436304/the-pten-inhibitor-bpv-pic-promotes-neuroprotection-against-amyloid-%C3%AE-peptide-25-35-induced-oxidative-stress-and-neurotoxicity
#2
Xiao-Ying Liu, Li-Jing Zhang, Zhou Chen, Li-Bin Liu
OBJECTIVES: The aim of this study was to elucidate the mechanism underlying the neuroprotective effects of the phosphatase and tensin homolog (PTEN) inhibitor, bisperoxovanadium-pic [bpV(pic)]. METHODS: We determined the effects of bpV(pic) on amyloid-β-peptide-(25-35)-induced neurotoxicity, particularly intracellular reactive oxygen species (ROS) production and mitochondria-mediated apoptotic signaling, in a human neuroblastoma (SH-SY5Y) cell model. RESULTS: We found that exposure of SH-SY5Y cells to amyloid β peptides (Aβ25-35) resulted in a significant reduction in cell viability accompanied by increased lactate dehydrogenase (LDH) release, elevated levels of intracellular ROS, and decreased superoxide dismutase (SOD) activities, all of which were reversed by co-treatment with bpV(pic)...
April 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/28430186/independence-of-nutrient-limitation-and-carbon-dioxide-impacts-on-the-southern-ocean-coccolithophore-emiliania-huxleyi
#3
Marius N Müller, Thomas W Trull, Gustaaf M Hallegraeff
Future oceanic conditions induced by anthropogenic greenhouse gas emissions include warming, acidification and reduced nutrient supply due to increased stratification. Some parts of the Southern Ocean are expected to show rapid changes, especially for carbonate mineral saturation. Here we compare the physiological response of the model coccolithophore Emiliania huxleyi (strain EHSO 5.14, originating from 50(o)S, 149(o)E) with pH/CO2 gradients (mimicking ocean acidification ranging from 1 to 4 × current pCO2 levels) under nutrient-limited (nitrogen and phosphorus) and -replete conditions...
April 21, 2017: ISME Journal
https://www.readbyqxmd.com/read/28424992/intravitreal-anti-vegf-treatment-for-choroidal-neovascularization-secondary-to-punctate-inner-choroidopathy
#4
T Barth, F Zeman, H Helbig, M-A Gamulescu
PURPOSE: To assess the outcome of patients with choroidal neovascularization (CNV) secondary to punctate inner choroidopathy (PIC) receiving intravitreal anti-VEGF (vascular endothelial growth factor) injections. METHODS: Sixteen eyes of 16 patients diagnosed with CNV secondary to PIC were retrospectively assessed. RESULTS: Eleven women and five men with a mean age of 35 years (SD 11, range 16-56 years) received intravitreal anti-VEGF for PIC-related CNV...
April 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28419990/effects-of-estradiol-on-autophagy-and-nrf-2-are-signals-after-cerebral-ischemia
#5
Litao Li, Jinghong Chen, Sujuan Sun, Jingru Zhao, Xiaoli Dong, Jianhua Wang
BACKGROUND/AIMS: Estradiol (EST) reduces the risk of stroke and decreases the incidence and progression of the disease because of its neuroprotective roles in inhibiting cell death that occurs in response to a variety of neuronal stimuli such as inflammation and oxidative stress. In this study, we determined the role played by autophagy and Nrf2-ARE signal pathways in the hippocampus regions in modulating cerebral ischemia under different EST conditions. METHODS: Western blot analysis and ELISA were used to determine the protein expression of autophagy and Nrf2-ARE pathways; and the levels of pro-inflammatory cytokines (PICs) and a key marker of oxidative stress...
April 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28417226/the-repertoire-of-bitter-taste-receptor-genes-in-canids
#6
REVIEW
Shuai Shang, Xiaoyang Wu, Jun Chen, Huanxin Zhang, Huaming Zhong, Qinguo Wei, Jiakuo Yan, Haotian Li, Guangshuai Liu, Weilai Sha, Honghai Zhang
Bitter taste receptors (Tas2rs) play important roles in mammalian defense mechanisms by helping animals detect and avoid toxins in food. Although Tas2r genes have been widely studied in several mammals, minimal research has been performed in canids. To analyze the genetic basis of Tas2r genes in canids, we first identified Tas2r genes in the wolf, maned wolf, red fox, corsac fox, Tibetan fox, fennec fox, dhole and African hunting dog. A total of 183 Tas2r genes, consisting of 118 intact genes, 6 partial genes and 59 pseudogenes, were detected...
April 17, 2017: Amino Acids
https://www.readbyqxmd.com/read/28411889/factibility-and-security-study-of-the-pics-af%C3%A2-plug-for-the-treatment-of-cryptoglandular-anal-fistula
#7
Fernando de la Portilla, María Luisa Reyes-Díaz, María Victoría Maestre, Rosa María Jiménez-Rodríguez, Ana María García-Cabrera, José M Díaz-Pavón, Jorge Manuel Vázquez-Monchul, Juan Antonio Villanueva
INTRODUCTION: The PICS-AF™ (Curaseal Inc.) device is a new plug made of collagen that has a retention system in the internal orifice. This pilot study was designed to assess both the feasibility and safety of this plug in the treatment of trans-sphincteric anal fístulas. METHODS: A total of 44 patients (34 men), with a mean age of 54.68±7.3, with trans-sphincteric anal fístulas were included in the study; 34 of them were analyzed. All patients were examined according to a strict preoperative protocol and until 6 months after surgery...
April 12, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28408910/new-hypervariable-ssr-markers-for-diversity-analysis-hybrid-purity-testing-and-trait-mapping-in-pigeonpea-cajanus-cajan-l-millspaugh
#8
Abhishek Bohra, Rintu Jha, Gaurav Pandey, Prakash G Patil, Rachit K Saxena, Indra P Singh, D Singh, R K Mishra, Ankita Mishra, F Singh, Rajeev K Varshney, N P Singh
Draft genome sequence in pigeonpea offers unprecedented opportunities for genomics assisted crop improvement via enabling access to genome-wide genetic markers. In the present study, 421 hypervariable simple sequence repeat (SSR) markers from the pigeonpea genome were screened on a panel of eight pigeonpea genotypes yielding marker validation and polymorphism percentages of 95.24 and 54.11%, respectively. The SSR marker assay uncovered a total of 570 alleles with three as an average number of alleles per marker...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28391537/virulence-factors-of-shiga-toxin-producing-escherichia-coli-and-the-risk-of-developing-haemolytic-uraemic-syndrome-in-norway-1992-2013
#9
U Naseer, I Løbersli, M Hindrum, T Bruvik, L T Brandal
Shiga toxin-producing Escherichia coli (STEC) may cause haemolytic uraemic syndrome (HUS). Age ≤5 years and presence of stx2a and eae are risk factors for the development of HUS. In this study, we investigated STEC isolates for the presence of adhesins, toxins and molecular risk assessment (MRA) factors to identify virulence genes associated with HUS development. We included non-duplicate isolates from all STEC infections (n = 340, HUS = 32) reported to the Norwegian National Reference Laboratory (NRL) for Enteropathogenic Bacteria from 1992 to 2013...
April 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28380753/hybrid-laser-written-waveguides-in-fused-silica-for-low-loss-and-polarization-independence
#10
Jun Guan, Xiang Liu, Patrick S Salter, Martin J Booth
Photonic integrated circuits (PICs) written with an ultrashort pulsed laser provide advantages in a range of applications, such as photon-based quantum information processing, where low insertion loss and low polarization dependence are critical concerns. Here we demonstrate the inscription of hybrid waveguides in fused silica at a pulse repetition rate of 1MHz that fulfill both these criteria. The mechanisms for propagation and coupling losses are identified and decoupled, with separate sections of the waveguide minimizing for each and an adiabatic mode conversion between the two...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28380544/digestion-and-nitrogen-balance-using-swine-diets-containing-increasing-proportions-of-coproduct-ingredients-and-formulated-using-the-net-energy-system
#11
J A Acosta, R D Boyd, J F Patience
Rising feed expenditures demand that our industry pursues strategies to lower the cost of production. One option is the adoption of the NE system, although many producers are hesitant to proceed without proof that NE estimates are reliable. The objective of this experiment was to compare the apparent total tract digestibility (ATTD) of energy and nutrients and the N retention (NR) of diets formulated using the NE system with increasing quantities of coproduct ingredients. The 5 dietary treatments included a control corn-soybean meal diet (CTL); the CTL plus 6% each of corn distiller's dried grains with solubles (DDGS), corn germ meal, and wheat middlings and NE equal to the CTL by adding soybean oil (CONS-18); the CONS-18 diet, without oil added, with NE content lower than the CTL (DECL-18); the CTL plus 12% each of corn DDGS, corn germ meal, and wheat middlings and NE equal to the CTL by adding soybean oil (CONS-36); and the CONS-36 diet, without oil added, with NE content lower than the CTL (DECL-36)...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28380520/the-addition-of-protein-bound-amino-acids-in-low-protein-diets-improves-the-metabolic-and-immunological-characteristics-in-fifteen-to-thirty-five-kg-pigs
#12
L Q Che, X Peng, L Hu, C Wu, Q Xu, Z F Fang, Y Lin, S Y Xu, J Li, B Feng, G Tian, R N Zhang, H Sun, D Wu, D W Chen
This study was to evaluate the effects of supplementation of AA form (crystalline vs. protein bound) in low-protein diets on growth, metabolic, and immunological characteristics of pigs. A total of 80 barrows (PIC 327 × 1050; 15.57 ± 0.13 kg BW and 48 ± 2 d of age), housed in 4 pigs per pen with 5 pens per treatment, were assigned to 4 dietary treatments of 17, 15, and 13% CP and 13% CP plus casein for 28 d. The crystalline AA were supplemented to meet the requirement of indispensable AA in pigs. Results showed that pigs fed the 13% CP diet or the 13% CP plus casein diet had lower ( < 0...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28380505/sid-lysine-requirement-of-immunologically-and-physically-castrated-male-pigs-during-the-grower-early-and-late-finisher-periods
#13
A J Elsbernd, C F M de Lange, K J Stalder, L A Karriker, J F Patience
The main objective of this experiment was to determine the standardized ileal digestible (SID) Lys requirement of immunologically castrated (IC) and physically castrated (PC) male pigs during 3 growth phases. An additional objective was to compare the ADFI of PC and IC after the second anti-gonadotropin releasing factor (GnRF) injection. Three hundred male pigs (PIC 359 × C29), 150 each of IC and PC, were allotted to 1 of 5 treatments: 80, 90, 100, 110, or 120% of the estimated Lys requirement using the modeling program...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28371762/d-tagatose-production-by-permeabilized-and-immobilized-lactobacillus-plantarum-using-whey-permeate
#14
J Jayamuthunagai, G Srisowmeya, M Chakravarthy, P Gautam
The aim of the work is to produce d-Tagatose by direct addition of alginate immobilized Lactobacillus plantarum cells to lactose hydrolysed whey permeate. The cells were untreated and immobilized (UIC), permeabilized and immobilized (PIC) and the relative activities were compared with purified l-arabinose isomerase (l-AI) for d-galactose isomerization. Successive lactose hydrolysis by β-galactosidase from Escherichia coli and d-galactose isomerization using l-AI from Lactobacillus plantarum was performed to investigate the in vivo production of d-tagatose in whey permeate...
March 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28370764/conference-pics
#15
(no author information available yet)
No abstract text is available yet for this article.
April 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28362323/optimizing-sample-size-to-assess-the-genetic-diversity-in-common-vetch-vicia-sativa-l-populations-using-start-codon-targeted-scot-markers
#16
Xutian Chai, Rui Dong, Wenxian Liu, Yanrong Wang, Zhipeng Liu
Common vetch (Vicia sativa subsp. sativa L.) is a self-pollinating annual forage legume with worldwide importance. Here, we investigate the optimal number of individuals that may represent the genetic diversity of a single population, using Start Codon Targeted (SCoT) markers. Two cultivated varieties and two wild accessions were evaluated using five SCoT primers, also testing different sampling sizes: 1, 2, 3, 5, 8, 10, 20, 30, 40, 50, and 60 individuals. The results showed that the number of alleles and the Polymorphism Information Content (PIC) were different among the four accessions...
March 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28356469/pics-in-motoneurons-do-not-scale-with-the-size-of-the-animal-a-possible-mechanism-for-faster-speed-of-muscle-contraction-in-smaller-species
#17
Seoan Huh, Ramamurthy Siripuram, Robert H Lee, Vladimir V Turkin, Derek O'Neil, Thomas M Hamm, Charles J Heckman, Marin Manuel
The majority of studies on the electrical properties of neurons are carried out in rodents, and in particular in mice. However, the minute size of this animal compared to humans potentially limits the relevance of the resulting insights. To be able to extrapolate results obtained in a small animal such as a rodent, one needs to have proper knowledge of the rules governing how electrical properties of neurons scale with the size of the animal. Generally speaking, electrical resistances of neurons increase as cell size decreases and thus maintenance of equal depolarization across cells of different sizes requires the underlying currents to decrease in proportion to the size decrease...
March 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28356354/n-terminal-half-of-transportin-sr2-interacts-with-hiv-integrase
#18
Vicky G Tsirkone, Jolien Blokken, Flore De Wit, Jolien Breemans, Stéphanie De Houwer, Zeger Debyser, Frauke Christ, Sergei V Strelkov
The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus. This protein plays a key role in HIV infection by facilitating the nuclear import of the pre-integration complex (PIC) which contains the viral DNA as well as several cellular and HIV proteins including the integrase. The process of nuclear import is considered to be the bottleneck of the viral replication cycle and therefore represents a promising target for anti-HIV drug design...
March 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28352913/highly-durable-photochromic-radical-complexes-having-no-steric-protections-of-radicals
#19
Yoichi Kobayashi, Yasuhiro Mishima, Katsuya Mutoh, Jiro Abe
Steric protection groups are usually necessary for stable radicals. However, here, we developed novel photochromic radical complexes which generate sterically unprotected imidazolyl and phenoxyl radicals upon UV light irradiation based on the phenoxyl-imidazolyl radical complex (PIC) framework. These photochromic compounds show excellent durability against repeated irradiation of intense nanosecond laser pulses even in polar protic solvents, such as ethanol.
March 29, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28338010/brilliant-petawatt-gamma-ray-pulse-generation-in-quantum-electrodynamic-laser-plasma-interaction
#20
H X Chang, B Qiao, T W Huang, Z Xu, C T Zhou, Y Q Gu, X Q Yan, M Zepf, X T He
We show a new resonance acceleration scheme for generating ultradense relativistic electron bunches in helical motions and hence emitting brilliant vortical γ-ray pulses in the quantum electrodynamic (QED) regime of circularly-polarized (CP) laser-plasma interactions. Here the combined effects of the radiation reaction recoil force and the self-generated magnetic fields result in not only trapping of a great amount of electrons in laser-produced plasma channel, but also significant broadening of the resonance bandwidth between laser frequency and that of electron betatron oscillation in the channel, which eventually leads to formation of the ultradense electron bunch under resonant helical motion in CP laser fields...
March 24, 2017: Scientific Reports
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