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https://www.readbyqxmd.com/read/27901601/activation-of-estrogen-response-element-independent-er%C3%AE-signaling-protects-female-mice-from-diet-induced-obesity
#1
Ali Yasrebi, Janelle A Rivera, Elizabeth A Krumm, Jennifer A Yang, Troy A Roepke
17β-estradiol (E2) regulates central and peripheral mechanisms that control energy and glucose homeostasis predominantly through estrogen receptor α (ERα) acting via receptor binding to estrogen response elements (ERE). ERα signaling is also involved in mediating the effects of E2 on diet-induced obesity (DIO), although the roles of ERE-dependent and -independent ERα signaling in ameliorating the effects of DIO remain largely unknown. We hypothesize that ERE-dependent ERα signaling is necessary to ameliorate the effects of DIO...
November 30, 2016: Endocrinology
https://www.readbyqxmd.com/read/27589337/the-impact-of-sulfatase-2-on-cancer-progression-and-prognosis-in-patients-with-renal-cell-carcinoma
#2
Shin Kumagai, Kei Ishibashi, Masao Kataoka, Toshiki Oguro, Yuichirou Kiko, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima
Heparan sulfate-specific endosulfatase-2, SULF-2, can modulate the signaling of HSPG-binding proteins. The involvement of SULF-2 in cancer growth varies by cancer type. The roles of SULF-2 expression in the progression and prognosis of renal cell carcinomas (RCCs) have not yet been fully clarified. In the present study, the expression levels of SULF-2 mRNA and protein in 49 clinical RCC samples were determined by RT-PCR and immunostaining. The existence of RCCs with higher SULF-2 expression and lower SULF-2 expression compared to the adjacent normal kidney tissues was suggested...
September 2, 2016: Cancer Science
https://www.readbyqxmd.com/read/27575947/neurobehavioral-deficits-in-the-kiko-mouse-model-of-friedreich-s-ataxia
#3
Marissa Z McMackin, Chelsea K Henderson, Gino A Cortopassi
Friedreich's Ataxia (FA) is a pediatric neurodegenerative disease whose clinical presentation includes ataxia, muscle weakness, and peripheral sensory neuropathy. The KIKO mouse is an animal model of FA with frataxin deficiency first described in 2002, but neurobehavioral deficits have never been described in this model. The identification of robust neurobehavioral deficits in KIKO mice could support the testing of drugs for FA, which currently has no approved therapy. We tested 13 neurobehavioral tasks to identify a robust KIKO phenotype: Open Field, Grip Strength Test(s), Cylinder, Skilled Forelimb Grasp Task(s), Treadmill Endurance, Locotronic Motor Coordination, Inverted Screen, Treadscan, and Von Frey...
January 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27160240/familial-hypertrophic-obstructive-cardiomyopathy-with-the-gla-e66q-mutation-and-zebra-body
#4
Masayoshi Oikawa, Nobuo Sakamoto, Atsushi Kobayashi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Yuichirou Kiko, Hajime Nakano, Takeharu Hayashi, Akinori Kimura, Yasuchika Takeishi
BACKGROUND: Fabry disease is caused by mutations in the α-galactosidase A (GLA) gene, which is located in X-chromosome coding for the lysosomal enzyme of GLA. Among many gene mutations, E66Q mutation is under discussion for its pathogenicity because there is no clinical report showing pathological evidence of Fabry disease with E66Q mutation. CASE PRESENTATION: A 65-year-old Japanese female was referred to our hospital for chest discomfort on effort. Transthoracic echocardiography showed severe left ventricular (LV) hypertrophy with LV outflow obstruction...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27096373/in-situ-imaging-reveals-the-biomass-of-giant-protists-in-the-global-ocean
#5
Tristan Biard, Lars Stemmann, Marc Picheral, Nicolas Mayot, Pieter Vandromme, Helena Hauss, Gabriel Gorsky, Lionel Guidi, Rainer Kiko, Fabrice Not
Planktonic organisms play crucial roles in oceanic food webs and global biogeochemical cycles. Most of our knowledge about the ecological impact of large zooplankton stems from research on abundant and robust crustaceans, and in particular copepods. A number of the other organisms that comprise planktonic communities are fragile, and therefore hard to sample and quantify, meaning that their abundances and effects on oceanic ecosystems are poorly understood. Here, using data from a worldwide in situ imaging survey of plankton larger than 600 μm, we show that a substantial part of the biomass of this size fraction consists of giant protists belonging to the Rhizaria, a super-group of mostly fragile unicellular marine organisms that includes the taxa Phaeodaria and Radiolaria (for example, orders Collodaria and Acantharia)...
April 28, 2016: Nature
https://www.readbyqxmd.com/read/27081970/measurement-of-the-transverse-single-spin-asymmetry-in-p-%C3%A2-p%C3%A2-w-%C3%A2-z-0-at-rhic
#6
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, A Aparin, D Arkhipkin, E C Aschenauer, A Attri, G S Averichev, X Bai, V Bairathi, A Banerjee, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, S Chattopadhyay, X Chen, J H Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, B di Ruzza, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, J Engelage, G Eppley, R Esha, O Evdokimov, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, A Gupta, S Gupta, W Guryn, A Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, D J Hofman, S Horvat, X Huang, H Z Huang, B Huang, T Huang, P Huck, T J Humanic, G Igo, W W Jacobs, H Jang, A Jentsch, J Jia, K Jiang, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z H Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, L Kumar, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, C Li, Y Li, W Li, X Li, X Li, T Lin, M A Lisa, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, R Ma, L Ma, G L Ma, Y G Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, D McDonald, K Meehan, J C Mei, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, B K Nandi, Md Nasim, T K Nayak, G Nigmatkulov, T Niida, L V Nogach, S Y Noh, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, J Putschke, H Qiu, A Quintero, S Ramachandran, R Raniwala, S Raniwala, R L Ray, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, A Roy, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, A Sarkar, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, M K Sharma, B Sharma, W Q Shen, Z Shi, S S Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, D Smirnov, N Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, M Sumbera, B Summa, Y Sun, Z Sun, X M Sun, B Surrow, D N Svirida, A H Tang, Z Tang, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, M Vandenbroucke, R Varma, A N Vasiliev, R Vertesi, F Videbæk, S Vokal, S A Voloshin, A Vossen, J S Wang, Y Wang, F Wang, Y Wang, H Wang, G Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, X Xie, W Xie, K Xin, N Xu, Y F Xu, Z Xu, Q H Xu, J Xu, H Xu, Q Yang, Y Yang, S Yang, Y Yang, C Yang, Y Yang, Z Ye, Z Ye, P Yepes, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, S Zhang, Z Zhang, S Zhang, J B Zhang, Y Zhang, J Zhang, J Zhang, X P Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We present the measurement of the transverse single-spin asymmetry of weak boson production in transversely polarized proton-proton collisions at sqrt[s]=500  GeV by the STAR experiment at RHIC. The measured observable is sensitive to the Sivers function, one of the transverse-momentum-dependent parton distribution functions, which is predicted to have the opposite sign in proton-proton collisions from that observed in deep inelastic lepton-proton scattering. These data provide the first experimental investigation of the nonuniversality of the Sivers function, fundamental to our understanding of QCD...
April 1, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27035295/beam-energy-dependence-of-the-third-harmonic-of-azimuthal-correlations-in-au-au-collisions-at-rhic
#7
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, A Aparin, D Arkhipkin, E C Aschenauer, A Attri, G S Averichev, X Bai, V Bairathi, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, A Chatterjee, S Chattopadhyay, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, B di Ruzza, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, J Engelage, G Eppley, R Esha, O Evdokimov, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, S Gupta, A Gupta, W Guryn, A I Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, T Huang, X Huang, B Huang, H Z Huang, P Huck, T J Humanic, G Igo, W W Jacobs, H Jang, A Jentsch, J Jia, K Jiang, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z H Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, L Kumar, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, X Li, C Li, X Li, Y Li, W Li, T Lin, M A Lisa, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, R Ma, G L Ma, Y G Ma, L Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, H S Matis, D McDonald, S McKinzie, K Meehan, J C Mei, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, B K Nandi, Md Nasim, T K Nayak, G Nigmatkulov, T Niida, L V Nogach, S Y Noh, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, J Putschke, H Qiu, A Quintero, S Ramachandran, S Raniwala, R Raniwala, R L Ray, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, A Sarkar, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, B Sharma, M K Sharma, W Q Shen, Z Shi, S S Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, N Smirnov, D Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, M Sumbera, B Summa, Z Sun, X M Sun, Y Sun, B Surrow, D N Svirida, Z Tang, A H Tang, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, M Vandenbroucke, R Varma, A N Vasiliev, R Vertesi, F Videbæk, S Vokal, S A Voloshin, A Vossen, F Wang, G Wang, J S Wang, H Wang, Y Wang, Y Wang, G Webb, J C Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, W Xie, G Xie, K Xin, Y F Xu, Q H Xu, N Xu, H Xu, Z Xu, J Xu, S Yang, Y Yang, Y Yang, C Yang, Y Yang, Q Yang, Z Ye, Z Ye, P Yepes, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, X P Zhang, Y Zhang, J Zhang, J Zhang, S Zhang, S Zhang, Z Zhang, J B Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We present results from a harmonic decomposition of two-particle azimuthal correlations measured with the STAR detector in Au+Au collisions for energies ranging from sqrt[s_{NN}]=7.7 to 200 GeV. The third harmonic v_{3}^{2}{2}=⟨cos3(ϕ_{1}-ϕ_{2})⟩, where ϕ_{1}-ϕ_{2} is the angular difference in azimuth, is studied as a function of the pseudorapidity difference between particle pairs Δη=η_{1}-η_{2}. Nonzero v_{3}^{2}{2} is directly related to the previously observed large-Δη narrow-Δϕ ridge correlations and has been shown in models to be sensitive to the existence of a low viscosity quark gluon plasma phase...
March 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27008326/retrospective-study-of-122-dogs-that-were-treated-with-the-antifibrinolytic-drug-aminocaproic-acid-2010-2012
#8
Megan Davis, Kiko Bracker
Antifibrinolytic drugs are used to promote hemostasis and decrease the need for red blood cell transfusion. Medical records of 122 dogs that were prescribed either oral or intravenous aminocaproic acid between 2010 and 2012 were evaluated retrospectively. Of the 122 dogs, three experienced possible drug-related adverse effects. No significant differences were identified between dogs that experienced adverse effects and those that did not and the possible adverse effects noted were all minor. All dogs that received packed red blood cell transfusions were evaluated for correlations between baseline packed cell volume or dose of red blood cells and aminocaproic acid dose and no correlation was identified...
May 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/26918982/centrality-and-transverse-momentum-dependence-of-elliptic-flow-of-multistrange-hadrons-and-%C3%AF-meson-in-au-au-collisions-at-%C3%A2-snn-200%C3%A2-%C3%A2-gev
#9
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, A Aparin, D Arkhipkin, E C Aschenauer, G S Averichev, V Bairathi, A Banerjee, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, A V Brandin, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, M C Cervantes, I Chakaberia, P Chaloupka, Z Chang, S Chattopadhyay, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, B di Ruzza, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, J Engelage, G Eppley, R Esha, O Evdokimov, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, S Gupta, A Gupta, W Guryn, A Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, D J Hofman, S Horvat, X Huang, B Huang, H Z Huang, P Huck, T J Humanic, G Igo, W W Jacobs, H Jang, K Jiang, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z H Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, T Kollegger, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, I Kulakov, L Kumar, R A Kycia, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, Z M Li, W Li, X Li, X Li, C Li, Y Li, M A Lisa, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, Y G Ma, G L Ma, L Ma, R Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, H Masui, H S Matis, D McDonald, K Meehan, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, B K Nandi, Md Nasim, T K Nayak, G Nigmatkulov, L V Nogach, S Y Noh, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, A Peterson, P Pile, M Planinic, J Pluta, N Poljak, K Poniatowska, J Porter, M Posik, A M Poskanzer, J Putschke, H Qiu, A Quintero, S Ramachandran, R Raniwala, S Raniwala, R L Ray, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, A Roy, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, A Sarkar, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, B Sharma, M K Sharma, W Q Shen, S S Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, D Smirnov, N Smirnov, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, M Sumbera, B Summa, X Sun, X M Sun, Y Sun, Z Sun, B Surrow, N Svirida, M A Szelezniak, A H Tang, Z Tang, T Tarnowsky, A Tawfik, J H Thomas, A R Timmins, D Tlusty, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, B A Trzeciak, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, M Vandenbroucke, R Varma, A N Vasiliev, R Vertesi, F Videbæk, Y P Viyogi, S Vokal, S A Voloshin, A Vossen, Y Wang, G Wang, J S Wang, H Wang, Y Wang, F Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y F Wu, Y Wu, Z G Xiao, W Xie, K Xin, N Xu, Z Xu, Q H Xu, Y F Xu, H Xu, Q Yang, Y Yang, Y Yang, S Yang, C Yang, Z Ye, P Yepes, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, Z Zhang, Y Zhang, J B Zhang, J Zhang, S Zhang, J Zhang, X P Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We present high precision measurements of elliptic flow near midrapidity (|y|<1.0) for multistrange hadrons and ϕ meson as a function of centrality and transverse momentum in Au+Au collisions at center of mass energy √[sNN]=200  GeV. We observe that the transverse momentum dependence of ϕ and Ω v2 is similar to that of π and p, respectively, which may indicate that the heavier strange quark flows as strongly as the lighter up and down quarks. This observation constitutes a clear piece of evidence for the development of partonic collectivity in heavy-ion collisions at the top RHIC energy...
February 12, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/26852864/interaction-of-peptide-transporter-1-with-d-glucose-and-l-glutamic-acid-possible-involvement-of-taste-receptors
#10
Hiroshi Arakawa, Taichi Ohmachi, Kiko Ichiba, Hiroki Kamioka, Takumi Tomono, Masahiko Kanagawa, Yoko Idota, Yasuko Hatano, Kentaro Yano, Kaori Morimoto, Takuo Ogihara
We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. After oral administration of glucose or mannitol to rats, CEX was administered together with a second dose of glucose or mannitol. Western blot analysis indicated that expression of PEPT1 in rat jejunum membrane was decreased by glucose, compared to mannitol. Furthermore, the maximum plasma concentration (Cmax) of orally administered CEX was reduced by glucose compared to mannitol...
January 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26778666/evaluation-of-conjunctival-bacterial-flora-in-a-herd-of-goats-in-the-midwestern-united-states
#11
Jessica M Meekins, Michael D Apley, Brian Lubbers, Lalitha Peddireddi, Amy J Rankin
OBJECTIVE: To identify conjunctival bacterial flora in healthy adult and newborn kid goats in the Midwestern United States and to compare vaginal and ocular surface flora in dam-kid pairs. ANIMALS STUDIED: Thirty mixed-breed (crosses between Boer, Kiko, and Syfan Spanish) goats, 20 adult does and 10 newborn kids. PROCEDURES: One eye of 15 adult goats (n = 15 eyes) and 5 kids (n = 5 eyes) was randomly selected. A subset of 5 adults (n = 10 eyes) and 5 kids (n = 10 eyes) underwent bilateral sampling...
January 18, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/26682681/alterations-in-the-levels-of-amyloid-%C3%AE-phospholipid-hydroperoxide-and-plasmalogen-in-the-blood-of-patients-with-alzheimer-s-disease-possible-interactions-between-amyloid-%C3%AE-and-these-lipids
#12
Shinji Yamashita, Takehiro Kiko, Hironori Fujiwara, Michio Hashimoto, Kiyotaka Nakagawa, Mikio Kinoshita, Katsutoshi Furukawa, Hiroyuki Arai, Teruo Miyazawa
Aside from accumulation of amyloid-β (Aβ) peptide in the brain, Alzheimer's disease (AD) has been reported as being associated with peroxidation of major phospholipids (e.g., phosphatidylcholine (PtdCho)) and degradation of antioxidative phospholipids (e.g., ethanolamine plasmalogen (PlsEtn)). In addition to its presence in the brain, Aβ is also found in blood; however, there is still little information about the levels of PtdCho hydroperoxide (PCOOH) and PlsEtn in the blood of patients with AD. In this study, by assuming a possible interaction among Aβ, PCOOH, and PlsEtn in blood circulation, we evaluated the levels of these molecules and correlations in blood samples that had been obtained from our former AD study for PCOOH measurement (Kiko et al...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26642040/a-new-family-of-anionic-fe-iii-spin-crossover-complexes-featuring-a-weak-field-n2o4-coordination-octahedron
#13
Kazuyuki Takahashi, Kiko Kawamukai, Mitsunobu Okai, Tomoyuki Mochida, Takahiro Sakurai, Hitoshi Ohta, Takashi Yamamoto, Yasuaki Einaga, Yoshihito Shiota, Kazunari Yoshizawa
Unprecedented anionic Fe(III) spin crossover (SCO) complexes involving a weak-field O,N,O-tridentate ligand were discovered. The SCO transition was evidenced by the temperature variations in magnetic susceptibility, Mössbauer spectrum, and coordination structure. The DFT calculations suggested that larger coefficients on the azo group in the HOMO-1 of a ligand might contribute to the enhancement of a ligand-field splitting energy. The present anionic SCO complex also exhibited the light- induced excited-spin-state trapping effect...
January 22, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26512629/evolution-and-function-of-dinosaur-teeth-at-ultramicrostructural-level-revealed-using-synchrotron-transmission-x-ray-microscopy
#14
Chun-Chieh Wang, Yen-Fang Song, Sheng-Rong Song, Qiang Ji, Cheng-Cheng Chiang, Qingjin Meng, Haibing Li, Kiko Hsiao, Yi-Chia Lu, Bor-Yuan Shew, Timothy Huang, Robert R Reisz
The relationship between tooth form and dietary preference is a crucial issue in vertebrate evolution. However, the mechanical properties of a tooth are influenced not only by its shape but also by its internal structure. Here, we use synchrotron transmission X-ray microscopy to examine the internal microstructures of multiple dinosaur teeth within a phylogenetic framework. We found that the internal microstructures of saurischian teeth are very different from advanced ornithischian teeth, reflecting differences in dental developmental strategies...
October 29, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26192623/aerobic-microbial-respiration-in-oceanic-oxygen-minimum-zones
#15
Tim Kalvelage, Gaute Lavik, Marlene M Jensen, Niels Peter Revsbech, Carolin Löscher, Harald Schunck, Dhwani K Desai, Helena Hauss, Rainer Kiko, Moritz Holtappels, Julie LaRoche, Ruth A Schmitz, Michelle I Graco, Marcel M M Kuypers
Oxygen minimum zones are major sites of fixed nitrogen loss in the ocean. Recent studies have highlighted the importance of anaerobic ammonium oxidation, anammox, in pelagic nitrogen removal. Sources of ammonium for the anammox reaction, however, remain controversial, as heterotrophic denitrification and alternative anaerobic pathways of organic matter remineralization cannot account for the ammonium requirements of reported anammox rates. Here, we explore the significance of microaerobic respiration as a source of ammonium during organic matter degradation in the oxygen-deficient waters off Namibia and Peru...
2015: PloS One
https://www.readbyqxmd.com/read/26141703/targeting-lipid-peroxidation-and-mitochondrial-imbalance-in-friedreich-s-ataxia
#16
Rosella Abeti, Ebru Uzun, Indhushri Renganathan, Tadashi Honda, Mark A Pook, Paola Giunti
Friedreich's ataxia (FRDA) is an autosomal recessive disorder, caused by reduced levels of the protein frataxin. This protein is located in the mitochondria, where it functions in the biogenesis of iron-sulphur clusters (ISCs), which are important for the function of the mitochondrial respiratory chain complexes. Moreover, disruption in iron biogenesis may lead to oxidative stress. Oxidative stress can be the cause and/or the consequence of mitochondrial energy imbalance, leading to cell death. Fibroblasts from two FRDA mouse models, YG8R and KIKO, were used to analyse two different categories of protective compounds: deuterised poly-unsaturated fatty acids (dPUFAs) and Nrf2-inducers...
September 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26098917/nitrogen-fuelling-of-the-pelagic-food-web-of-the-tropical-atlantic
#17
Vera Sandel, Rainer Kiko, Peter Brandt, Marcus Dengler, Lars Stemmann, Pieter Vandromme, Ulrich Sommer, Helena Hauss
We estimated the relative contribution of atmosphere (ic Nitrogen (N) input (wet and dry deposition and N fixation) to the epipelagic food web by measuring N isotopes of different functional groups of epipelagic zooplankton along 23°W (17°N-4°S) and 18°N (20-24°W) in the Eastern Tropical Atlantic. Results were related to water column observations of nutrient distribution and vertical diffusive flux as well as colony abundance of Trichodesmium obtained with an Underwater Vision Profiler (UVP5). The thickness and depth of the nitracline and phosphocline proved to be significant predictors of zooplankton stable N isotope values...
2015: PloS One
https://www.readbyqxmd.com/read/26090105/the-effects-of-tannins-containing-ground-pine-bark-diet-upon-nutrient-digestion-nitrogen-balance-and-mineral-retention-in-meat-goats
#18
Byeng Ryel Min, Sandra Solaiman, Thomas Terrill, Aina Ramsay, Irene Mueller-Harvey
BACKGROUND: Pine bark is a rich source of phytochemical compounds including tannins, phenolic acids, anthocyanins, and fatty acids. These phytochemicals have potential to significantly impact on animal health and animal production. The goal of this work is to measure the effects of tannins in ground pine bark as a partial feed replacement on feed intake, dietary apparent digestibility, nitrogen balance, and mineral retention in meat goats. RESULTS: Eighteen Kiko cross goats (initial BW = 31...
2015: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/25854861/administration-of-fenoldopam-in-critically-ill-small-animal-patients-with-acute-kidney-injury-28-dogs-and-34-cats-2008-2012
#19
Lindsey K Nielsen, Kiko Bracker, Lori Lyn Price
OBJECTIVE: To describe the clinical features and outcomes of critically ill dogs and cats with acute kidney injury (AKI) receiving fenoldopam infusions compared to patients with AKI that did not receive fenoldopam. DESIGN: Retrospective clinical study from May 1, 2008 until June 1, 2012. SETTING: Private emergency and specialty referral hospital. ANIMALS: Client-owned dogs (28) and cats (34) with AKI that received fenoldopam compared with similar patients with AKI (30 dogs and 30 cats) that did not...
May 2015: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/25343027/preslaughter-diet-management-in-sheep-and-goats-effects-on-physiological-responses-and-microbial-loads-on-skin-and-carcass
#20
Govind Kannan, Venkat R Gutta, Jung Hoon Lee, Brou Kouakou, Will R Getz, George W McCommon
Sixteen crossbred buck goats (Kiko x Spanish; BW = 32.8 kg) and wether sheep (Dorset x Suffolk; BW = 39.9 kg) were used to determine the effect of preslaughter diet and feed deprivation time (FDT) on physiological responses and microbial loads on skin and carcasses. Experimental animals were fed either a concentrate (CD) or a hay diet (HD) for 4 d and then deprived of feed for either 12-h or 24-h before slaughter. Blood samples were collected for plasma cortisol and blood metabolite analyses. Longisimus muscle (LM) pH was measured...
2014: Journal of Animal Science and Biotechnology
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