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https://www.readbyqxmd.com/read/29791566/cytidine-phosphate-guanosine-oligodeoxynucleotides-in-combination-with-cd40-ligand-decrease-periodontal-inflammation-and-alveolar-bone-loss-in-a-tlr9-independent-manner
#1
Qian Zhao, Yang Hu, Shu Deng, Pei Yu, Bowen Chen, Zuomin Wang, Xiaozhe Han
Local administration of toll-like receptor 9 (TLR9), agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG ODNs), and CD40 ligand (CD40L) can decrease ligature-induced periodontal inflammation and bone loss in wild type (WT) mouse. OBJECTIVE: This study aimed to explore whether such effect is dependent on TLR9 signaling. MATERIAL AND METHODS: Purified spleen B cells isolated from WT C57BL/6J mice and TLR9 knockout (KO) mice were cultured for 48 hours under the following conditions: CD40L, CpG+CD40L, CpG at low, medium and high doses...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29790498/rooibos-tea-extracts-inhibit-osteoclast-formation-and-activity-through-the-attenuation-of-nf-%C3%AE%C2%BAb-activity-in-raw264-7-murine-macrophages
#2
Shaakirah Moosa, Abe E Kasonga, Vishwa Deepak, Sumari Marais, Innocentia B Magoshi, Megan J Bester, Marlena C Kruger, Magdalena Coetzee
Rooibos tea is a naturally sweet and aromatic tea that is native to the Western Cape province of South Africa. Rooibos is usually fermented to produce the traditional reddish brown colour and has been found to have numerous health benefits. These include beneficial effects on osteoblasts; however, its effects on osteoclast formation and activity are unknown. Osteoclasts are large, multinucleated cells responsible for bone resorption. Binding of RANKL to its receptor on osteoclast precursors triggers the NF-κB signalling pathway leading to the formation of osteoclasts...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29787635/abnormal-bone-remodeling-activity-of-dental-follicle-cells-from-a-cleidocranial-dysplasia-patient
#3
Yang Liu, Xianli Zhang, Xiangyu Sun, Xiaozhe Wang, Chenying Zhang, Shuguo Zheng
OBJECTIVES: To explore the role of dental follicle cells (DFCs) with a novel cleidocranial dysplasia (CCD) causative gene RUNX2 mutation (DFCsRUNX 2+/m ) in delayed permanent tooth eruption. MATERIALS AND METHODS: A CCD patient with typical clinical features was involved in this study. DFCsRUNX 2+/m were cultured and DNA was extracted for RUNX2 mutation screening. Measurements of cell proliferation, alkaline phosphatase (ALP) activity, alizarin red staining and osteoblast-specific genes expression were performed to assess osteogenesis of DFCsRUNX 2+/m ...
May 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29787542/hemorrhagic-shock-alters-fracture-callus-composition-and-activates-the-il6-and-rankl-opg-pathway-in-mice
#4
Katrin Bundkirchen, Christian Macke, Nina Angrisani, Luisa M Schäck, Sandra Noack, Michael Fehr, Christian Krettek, Claudia Neunaber
BACKGROUND: Fracture and hemorrhagic shock often lead to impaired fracture healing. To elucidate underlying pathogenesis this study aims to analyze histological properties during fracture healing after hemorrhagic shock and involved signaling pathways in mice. METHODS: Male C57BL/6NCrl mice were assigned into five groups. Control group underwent no interventions. Sham group got a catheter and external fixator but neither blood loss nor osteotomy. Trauma-hemorrhage (TH) group received a pressure controlled hemorrhagic shock, osteotomy (Fx) group an osteotomy and fixator, and combined trauma (THFx) group both hemorrhagic shock and externally fixed osteotomy...
April 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29786751/inhibition-of-osteoclastogenesis-for-periprosthetic-osteolysis-therapy-through-the-suppression-of-p38-signaling-by-fraxetin
#5
Jia-Cheng Liao, Zhao-Xia Wei, Chang Zhao, Zhong-Ping Ma, Dao-Zhang Cai
Periprosthetic osteolysis belongs to osteolytic diseases, which often occur due to an imbalance between osteoclast and osteoblast number or activity. Fraxetin, a natural plant extract, inhibits osteoblast apoptosis and has therapeutic potential for treating osteolytic diseases. However, data pertaining to the effects of fraxetin on osteoclasts are limited. In the present study, it was demonstrated that the inhibition of osteoclastogenesis by fraxetin had an important role on the therapy of titanium particle‑induced osteolysis in vivo...
May 21, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29786151/time-dependent-loss-of-trabecular-bone-in-human-tibial-plateau-fractures
#6
Lucian Bogdan Solomon, David Kitchen, Paul Hamill Anderson, Dongqing Yang, Yolandi Starczak, Masakazu Kogawa, Egon Perilli, Peter Jonathan Smitham, Mark Sean Rickman, Dominic Thewlis, Gerald James Atkins
We investigated if time between injury and surgery affects cancellous bone properties in patients suffering tibial plateau fractures (TPF), in terms of structural integrity and gene expression controlling bone loss. A cohort of 29 TPF, operated 1-17 days post-injury, had biopsies from the fracture and an equivalent contralateral limb site, at surgery. Samples were assessed using micro-computed tomography and real-time RT-PCR analysis for the expression of genes known to be involved in bone remodeling and fracture healing...
May 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29782859/a-paeonol-derivative-yph-pa3-promotes-the-differentiation-of-monocyte-macrophage-lineage-precursor-cells-into-osteoblasts-and-enhances-their-autophagy
#7
Chun-Hao Tsai, Ming-Hua Hsu, Po-Hao Huang, Chin-Tung Hsieh, Ying-Ming Chiu, Dong-Chen Shieh, Yi-Ju Lee, Gregory J Tsay, Yi-Ying Wu
Previous studies have indicated that paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting the ERK, p38, and NF-κB pathway. We modified paeonol to form a new compound, YPH-PA3, and found that it promoted osteoclastogenesis rather than inhibited it the way paeonol does. The aim of this study is to investigate the mechanisms involved in YPH-PA3-promoted osteoclastogenesis. YPH-PA3-promoted differentiation of RAW264.7 cells (human monocytes) into osteoclasts is activated through ERK/p38/JNK phosphorylation, affecting c-FOS, NF-κB, and NFATc2...
May 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29782843/role-of-nutritional-vitamin-d-in-osteoporosis-treatment
#8
REVIEW
Yi-Chou Hou, Chia-Chao Wu, Min-Tser Liao, Jia-Fwu Shyu, Chi-Feng Hung, Tzung-Hai Yen, Chien-Lin Lu, Kuo-Cheng Lu
Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and microarchitectural deterioration of bone tissue. The World Health Organization has defined osteoporosis as a decrease in bone mass (50%) and bony quality (50%). Vitamin D, a steroid hormone, is crucial for skeletal health and in mineral metabolism. Its direct action on osteoblasts and osteoclasts and interaction with nonskeletal tissues help in maintaining a balance between bone turnover and bone growth. Vitamin D affects the activity of osteoblasts, osteoclasts, and osteocytes, suggesting that it affects bone formation, bone resorption, and bone quality...
May 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29781148/improved-osteogenesis-of-boron-incorporated-calcium-silicate-coatings-via-immunomodulatory-effects
#9
Xiang Lu, Kai Li, Youtao Xie, Shengcai Qi, Qingyi Shen, Jiangming Yu, Liping Huang, Xuebin Zheng
Osteoimmunology has revealed the importance of a favorable immune response for successful biomaterial-mediated osteogenesis. Boron-incorporated calcium silicate (Ca11 Si4 B2 O22 , B-CS) coating has been reported as a potential candidate for improving osteogenesis in orthopedic applications in vitro. However, relatively little is known about its effects on the immune response and subsequent osteogenesis. In this work, the immunomodulatory properties of the B-CS coating and its specific mechanism of action were explored...
May 20, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29777507/rankl-expression-is-increased-in-circulating-mononuclear-cells-of-patients-with-calcific-aortic-stenosis
#10
Marcello Rattazzi, Elisabetta Faggin, Elisa Bertacco, Roberta Buso, Massimo Puato, Mario Plebani, Martina Zaninotto, Davide Condotta, Giacomo Zoppellaro, Leopoldo Pagliani, Giuseppe Tarantini, Sabino Iliceto, Elisa Covolo, Giuseppe Faggian, Francesco Onorati, Mikhail Dodonov, Alessandro Daniotti, Paola Pantano, Zoran Olivari, Giovanni Benfari, Paolo Pauletto
We aimed to investigate whether the expression of the OPG/RANK/RANKL triad in peripheral blood mononuclear cells (PBMC) and circulating levels of markers of ectopic mineralization (OPG, FGF-23, PPi) are modified in patients with calcific aortic valve disease (CAVD). We found that patients affected by CAVD (n = 50) had significantly higher circulating levels of OPG as compared to control individuals (p = 0.003). No differences between the two groups were found in FGF-23 and PPi levels. RANKL expression was higher in the PBMC from CAVD patients (p = 0...
May 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29774992/interleukin-17a-promotes-osteogenic-differentiation-by-increasing-opg-rankl-ratio-in-stem-cells-from-human-exfoliated-deciduous-teeth-shed
#11
Alphonsa-Sebastian Alphy, Thirumulu-Ponnuraj Kannan, Mohd-Nor Norazmi, Asma-Abdullah Nurul
Stem cells derived from human exfoliated deciduous teeth (SHED) represent a promising cell source for bone tissue regeneration. The present study evaluated the effects of interleukin 17A (IL-17A) on the osteogenic differentiation of SHED. SHED were cultured in complete alpha minimum essential medium supplemented with osteoinducing reagents and treated with recombinant IL-17A. The cells were quantitatively analyzed for proliferative activity by MTS assay, cell markers expression as well as apoptotic activity by flow cytometry...
May 18, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29774578/the-immunobiology-of-rankl-and-myeloid-derived-suppressor-cell-activation-in-igg4-related-sclerosing-cholangitis
#12
Min Lian, Qixia Wang, Xiang Jiang, Jun Zhang, Yiran Wei, Yanmei Li, Bo Li, Weihua Chen, Haiyan Zhang, Qi Miao, Yanshen Peng, Xiao Xiao, Li Sheng, Weici Zhang, Jingyuan Fang, Ruqi Tang, M Eric Gershwin, Xiong Ma
The primary function of myeloid derived suppressor cells (MDSCs) is reflected in their immune modulatory role in several immune-mediated diseases. In IgG4-related disease (IgG4-RD), it has been hypothesized that there are selective regulatory defects that lead to a Th2 bias immune response. Herein we have taken advantage of a large cohort of patients with IgG4-related sclerosing cholangitis (IgG4-SC), the most common extra-pancreatic involvement of IgG4-RD, as well as controls consisting of primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) and healthy volunteers, to study MDSC...
May 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29773986/flavopiridol-protects-bone-tissue-by-attenuating-rankl-induced-osteoclast-formation
#13
Zi'ang Hu, Yilei Chen, Lijiang Song, Jasper H N Yik, Dominik R Haudenschild, Shunwu Fan
Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyclin-dependent kinase 9 (CDK9) is the major regulator of inflammation, as CDK9 inhibitor flavopiridol effectively suppress injury-induced inflammatory response. The objective of this study was to investigate the underlying mechanism through which flavopiridol regulates bone resorption...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29773595/therapeutic-effects-of-the-novel-subtype-selective-histone-deacetylase-hdac-inhibitor-chidamide-on-myeloma-associated-bone-disease
#14
Jingsong He, Qingxiao Chen, Huiyao Gu, Jing Chen, Enfan Zhang, Xing Guo, Xi Huang, Haimeng Yan, DongHua He, Yang Yang, Yi Zhao, Gang Wang, Huang He, Qing Yi, Zhen Cai
Histone deacetylases are promising therapeutic targets in hematological malignancies. In the present work, we investigated the effect of chidamide, a new subtype-selective histone deacetylase inhibitor that was independently produced in China, on multiple myeloma and its associated bone diseases using different models. The cytotoxicity of chidamide toward myeloma is due to its induction of cell apoptosis and cell cycle arrest by increasing the levels of caspase family proteins, including p21 and p27, among others...
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29772836/soybean-hop-alleviates-estrogen-deficiency-related-bone-loss-and-metabolic-dysfunction-in-ovariectomized-rats-fed-a-high-fat-diet
#15
Dasom Noh, Yeni Lim, Hansol Lee, Hyejin Kim, Oran Kwon
Soybeans and hops have been traditionally used as a natural estrogen replacement therapy and their major active ingredients, isoflavones and prenylflavanones, are known to have estrogenic/antiestrogenic effects depending on the target organ. However, their potential benefits are still subject to controversies. The present study investigated the dual effect of soy isoflavones plus hop prenylflavanones (Soy-Hop) on bone loss and metabolic dysfunction under estrogen deficient condition. Rats were sham-operated ( n = 10) or ovariectomized (OVX; n = 40) and then fed a high-fat diet (HFD) to develop hyperlipidemia in OVX rats within the experimental period of 8 weeks...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29763384/the-effects-of-dihydroartemisinin-on-inflammatory-bowel-disease-related-bone-loss-in-a-rat-model
#16
Xingtao Ge, Zhijian Chen, Zhenjie Xu, Fang Lv, Kewei Zhang, Yu Yang
Bone loss is one of the important extra-intestinal manifestations in patients with inflammatory bowel diseases (IBDs). Compounds derived from natural products have been used to treat IBDs. However, the role of natural products on IBD-induced bone loss is not completely clarified. In the present study, we observed the effects of dihydroartemisinin (DHA), an antimalaria drug, on IBD and IBD-induced bone loss in a rat model. Chronic IBD model was established in Sprague-Dawley rats by giving them 2.5% dextran sodium sulfate in drinking water...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29761933/th1-th17-th22-immune-response-and-their-association-with-joint-pain-imagenological-bone-loss-rankl-expression-and-osteoclast-activity-in-temporomandibular-joint-osteoarthritis-a-preliminary-report
#17
Gustavo Monasterio, Francisca Castillo, Leticia Rojas, Emilio A Cafferata, Carla Alvarez, Paola Carvajal, Cristián Núñez, Guillermo Flores, Walter Díaz, Rolando Vernal
It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17, and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22-response in the TMJ-OA pathophysiology has not been established...
May 15, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29761497/vibration-enhances-pge-2-il-6-and-il-8-expression-in-compressed-hpdl-cells-via-cyclooxygenase-pathway
#18
Pussadee Phusuntornsakul, Suwanna Jitpukdeebodintra, Prasit Pavasant, Chidchanok Leethanakul
BACKGROUND: Although vibration combined with orthodontic force may accelerate orthodontic tooth movement, little is known about the mechanisms that regulate the associated cellular responses. The propose of this study was to investigate whether mechanical vibration combined with compressive force regulates COX-2/PGE2 , IL-6 and IL-8 mRNA and protein expression in human periodontal ligament (hPDL) cells via the cyclooxygenase pathway. METHODS: The primary cultured hPDL cells were exposed to mechanical vibration, compressive force or a combination of both mechanical vibration and compressive force at 24, 48, 72 h...
May 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29760402/roles-of-enhancer-rnas-in-rankl-induced-osteoclast-differentiation-identified-by-genome-wide-cap-analysis-of-gene-expression-using-crispr-cas9
#19
Yukako Sakaguchi, Keizo Nishikawa, Shigeto Seno, Hideo Matsuda, Hiroshi Takayanagi, Masaru Ishii
Bidirectional transcription has been proposed to play a role associated with enhancer activity. Transcripts called enhancer RNAs (eRNAs) play important roles in gene regulation; however, their roles in osteoclasts are unknown. To analyse eRNAs in osteoclasts comprehensively, we used cap-analysis of gene expression (CAGE) to detect adjacent transcription start sites (TSSs) that were distant from promoters for protein-coding gene expression. When comparing bidirectional TSSs between osteoclast precursors and osteoclasts, we found that bidirectional TSSs were located in the 5'-flanking regions of the Nrp2 and Dcstamp genes...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29758362/the-anti-epileptic-drugs-valproate-carbamazepine-and-levetiracetam-cause-bone-loss-and-modulate-wnt-inhibitors-in-normal-and-ovariectomised-rats
#20
Bushra Parveen, Ambrish Kumar Tiwari, Moon Jain, Subhashis Pal, Naibedya Chattopadhyay, Manjari Tripathi, Divya Vohora
Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs). Women are the vulnerable targets owing to post-menopausal bone loss. In the present work, we evaluated the effect of 10 weeks of treatment with AED therapy (carbamazepine, CBZ, 75 mg/kg; sodium valproate, SVP, 300 mg/kg; levetiracetam, LTM, 150 mg/kg) on bone mineral density and microarchitecture at femoral epiphysis, lumbar vertebrae and proximal tibia of normal and ovariectomised Wistar rats...
May 11, 2018: Bone
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