new england

BACKGROUND: Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Portal hypertension is the primary sequelae of cirrhosis and is associated with the development of variceal haemorrhage, ascites, hepatic encephalopathy and infection, collectively termed hepatic decompensation, which leads to hospitalisation and mortality. It remains uncertain whether administering a non-selective beta-blocker (NSBB), specifically carvedilol, at an earlier stage, i...

No abstract text is available yet for this article.

New England Journal of Medicine, Volume 390, Issue 15, Page 1356-1357, April 2024.

New England Journal of Medicine, Volume 390, Issue 15, Page 1349-1351, April 2024.

New England Journal of Medicine, Volume 390, Issue 15, April 2024.

New England Journal of Medicine, Volume 390, Issue 15, Page 1354-1356, April 2024.

New England Journal of Medicine, Volume 390, Issue 15, Page 1352-1353, April 2024.

Genetic drift in infectious disease transmission results from randomness of transmission and host recovery or death. The strength of genetic drift for SARS-CoV-2 transmission is expected to be high due to high levels of superspreading, and this is expected to substantially impact disease epidemiology and evolution. However, we don't yet have an understanding of how genetic drift changes over time or across locations. Furthermore, noise that results from data collection can potentially confound estimates of genetic drift...

BACKGROUND: Chronic subdural haematoma (cSDH) is a common neurosurgical pathology affecting older patients with other health conditions. A significant proportion (up-to 90%) of referrals for surgery in neurosciences units (NSU) come from secondary care. However, the organisation of this care and the experience of patients repatriated to non-specialist centres are currently unclear. OBJECTIVES: This study aimed to clarify patient outcome in non-specialist centres following NSU discharge for cSDH surgery and to understand key system challenges...

BACKGROUND: Kawasaki disease is a systemic vascular disease with an unclear pathophysiology that primarily affects children under the age of five. Research on immune control in Kawasaki disease has been gaining attention. This study aims to apply a bibliometric analysis to examine the present and future directions of immune control in Kawasaki disease. METHODS: By utilizing the themes "Kawasaki disease," "Kawasaki syndrome," and "immune control," the Web of Science Core Collection database was searched for publications on immune control in Kawasaki disease...

OBJECTIVE: Most surgeons employ an endovascular first approach to the treatment of peripheral arterial disease (PAD), but controversy remains regarding the ideal interventions for the management of isolated popliteal artery disease (IPAD). Indeed, there are a paucity of data that compare outcomes of popliteal stents versus other peripheral vascular interventions (PVI). The goal of this study was to evaluate outcomes of PVI in IPAD. METHODS: The Vascular Study Group of New England database was queried for all IPAD PVI performed for atherosclerotic occlusive disease from 2010-2021...

This paper explores news media discourse about care.data: an NHS England programme of work for amalgamating and sharing patient data from primary care for planning and research. It was scrapped in 2016 after three years of public outcry, delays and around 1.5 million opt-outs. I examine UK news media coverage of this programme through the 'fire object' metaphor, focusing upon the visions of purpose and value it inspired, the abrupt discontinuities, juxtapositions and transformations it performed, and the matters of concern that went unheeded...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

New England Journal of Medicine, Volume 390, Issue 14, Page 1333-1338, April 2024.

New England Journal of Medicine, Volume 390, Issue 14, Page 1329-1332, April 2024.

New England Journal of Medicine, Volume 390, Issue 14, Page 1328-1329, April 2024.

New England Journal of Medicine, Volume 390, Issue 14, Page 1325-1327, April 2024.

New England Journal of Medicine, Volume 390, Issue 14, Page 1324-1325, April 2024.

New England Journal of Medicine, Volume 390, Issue 14, Page 1312-1322, April 2024.