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https://www.readbyqxmd.com/read/29792245/the-over-35s-early-intervention-in-psychosis-services-entering-uncharted-territory
#1
Felix Clay, Sophie Allan, Serena Lai, Siona Laverty, Grace Jagger, Cate Treise, Jesus Perez
Aims and methodFollowing the introduction of new standards for early intervention in psychosis (EIP) in England, EIP services are accepting referrals for people aged 35-65. The Cambridgeshire and Peterborough EIP service (CAMEO) aimed to explore the immediate implications for the service, especially with regards to referral numbers and sources. Data were collected from April 2016 to June 2017. RESULTS: Referrals for over-35s represented 25.7% of all new referrals. Fifty per cent of referrals for over-35s were accepted onto caseload (40...
May 24, 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29791831/the-lymph-node-and-the-metastasis
#3
Vivianne Tjan-Heijnen, Giuseppe Viale
New England Journal of Medicine, Volume 378, Issue 21, Page 2045-2046, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791830/learning-from-a-trial-stopped-by-a-data-and-safety-monitoring-board
#4
EDITORIAL
David Harrington, Jeffrey M Drazen
New England Journal of Medicine, Volume 378, Issue 21, Page 2031-2032, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791829/burosumab-therapy-in-children-with-x-linked-hypophosphatemia
#5
Thomas O Carpenter, Michael P Whyte, Erik A Imel, Annemieke M Boot, Wolfgang Högler, Agnès Linglart, Raja Padidela, William Van't Hoff, Meng Mao, Chao-Yin Chen, Alison Skrinar, Emil Kakkis, Javier San Martin, Anthony A Portale
BACKGROUND: X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities. We investigated burosumab, a monoclonal antibody that targets FGF-23, in patients with X-linked hypophosphatemia. METHODS: In an open-label, phase 2 trial, we randomly assigned 52 children with X-linked hypophosphatemia, in a 1:1 ratio, to receive subcutaneous burosumab either every 2 weeks or every 4 weeks; the dose was adjusted to achieve a serum phosphorus level at the low end of the normal range...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791828/diagnosis-and-management-of-the-antiphospholipid-syndrome
#6
David Garcia, Doruk Erkan
New England Journal of Medicine, Volume 378, Issue 21, Page 2010-2021, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791827/a-shocking-turn-of-events
#7
Ersilia M DeFilippis, Anand Vaidya, David Braun, Neal Lakdawala, Piotr Sobieszczyk
New England Journal of Medicine, Volume 378, Issue 21, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791822/extracorporeal-membrane-oxygenation-for-severe-acute-respiratory-distress-syndrome
#8
Alain Combes, David Hajage, Gilles Capellier, Alexandre Demoule, Sylvain Lavoué, Christophe Guervilly, Daniel Da Silva, Lara Zafrani, Patrice Tirot, Benoit Veber, Eric Maury, Bruno Levy, Yves Cohen, Christian Richard, Pierre Kalfon, Lila Bouadma, Hossein Mehdaoui, Gaëtan Beduneau, Guillaume Lebreton, Laurent Brochard, Niall D Ferguson, Eddy Fan, Arthur S Slutsky, Daniel Brodie, Alain Mercat
BACKGROUND: The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. METHODS: In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria - a ratio of partial pressure of arterial oxygen (Pao2 ) to the fraction of inspired oxygen (Fio2 ) of less than 50 mm Hg for more than 3 hours; a Pao2 :Fio2 of less than 80 mm Hg for more than 6 hours; or an arterial blood pH of less than 7...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791821/tinea-capitis-in-a-newborn
#9
Christian Fremerey, Pietro Nenoff
New England Journal of Medicine, Volume 378, Issue 21, Page 2022-2022, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791819/ecmo-for-severe-ards
#10
EDITORIAL
C Corey Hardin, Kathryn Hibbert
New England Journal of Medicine, Volume 378, Issue 21, Page 2032-2034, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791818/retinal-vasculitis-in-takayasu-s-arteritis
#11
Priya Bajgai, Ramandeep Singh
New England Journal of Medicine, Volume 378, Issue 21, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791817/p53-and-me
#12
Shekinah N C Elmore
New England Journal of Medicine, Volume 378, Issue 21, Page 1962-1963, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791816/fast-forward-neoadjuvant-cancer-immunotherapy
#13
EDITORIAL
Thomas F Gajewski
New England Journal of Medicine, Volume 378, Issue 21, Page 2034-2035, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791813/higher-lung-cancer-incidence-in-young-women-than-young-men-in-the-united-states
#14
Ahmedin Jemal, Kimberly D Miller, Jiemin Ma, Rebecca L Siegel, Stacey A Fedewa, Farhad Islami, Susan S Devesa, Michael J Thun
BACKGROUND: Previous studies showed a higher incidence of lung cancer among young women than among young men in the United States. Whether this pattern has continued in contemporary birth cohorts and, if so, whether it can be fully explained by sex differences in smoking behaviors are unknown. METHODS: We examined the nationwide population-based incidence of lung cancer according to sex, race or ethnic group, age group (30 to 34, 35 to 39, 40 to 44, 45 to 49, and 50 to 54 years), year of birth (1945 to 1980), and calendar period of diagnosis (1995-1999, 2000-2004, 2005-2009, and 2010-2014), and we calculated female-to-male incidence rate ratios...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29788906/influences-on-the-adoption-of-patient-safety-innovation-in-primary-care-a-qualitative-exploration-of-staff-perspectives
#15
Ian Litchfield, Paramjit Gill, Tony Avery, Stephen Campbell, Katherine Perryman, Kate Marsden, Sheila Greenfield
BACKGROUND: Primary care is changing rapidly to meet the needs of an ageing and chronically ill population. New ways of working are called for yet the introduction of innovative service interventions is complicated by organisational challenges arising from its scale and diversity and the growing complexity of patients and their care. One such intervention is the multi-strand, single platform, Patient Safety Toolkit developed to help practices provide safer care in this dynamic and pressured environment where the likelihood of adverse incidents is increasing...
May 22, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29785689/the-impact-of-hospital-costing-methods-on-cost-effectiveness-analysis-a-case-study
#16
José Leal, Stefania Manetti, James Buchanan
BACKGROUND: Several methods exist to cost hospital contacts when estimating the cost effectiveness of a new intervention. However, the implications of choosing a particular approach remain unclear. We compare the use of the three main diagnosis-related group (DRG)-based national unit costs in England to determine whether choice of approach can impact on economic evaluation results. METHODS: A cost-utility model was developed to compare secondary fracture prevention models of care for hip fracture patients, using data from large primary and hospital care administrative datasets in England...
May 22, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29783850/the-utility-of-anti-inflammatory-agents-in-cardiovascular-disease-a-novel-perspective-on-the-treatment-of-atherosclerosis
#17
Santhosh J Kottoor, Rohit R Arora
Approximately 40% of heart attack survivors remain at increased risk of recurrent cardiovascular events, despite the current treatment options showing that atherothrombosis is not exclusively a disorder of lipoprotein aggregation in the arterial wall. Clinical and experimental data suggest that inflammation plays an important role in atherothrombosis independent of the cholesterol level. Acute-phase reactants, such as C-reactive protein, increase in patients with coronary artery disease and are known to predict adverse outcomes in such patients...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29779544/prescribing-practices-of-rural-physicians-waivered-to-prescribe-buprenorphine
#18
C Holly A Andrilla, Cynthia Coulthard, Davis G Patterson
INTRODUCTION: Opioid use disorder is a serious public health burden, especially throughout rural America. Although efforts have been made to increase the availability of buprenorphine (an office-based medication-assisted treatment), more than 60% of rural counties in the U.S. lack a physician with a Drug Enforcement Administration waiver to prescribe it. METHODS: This study surveyed all rural physicians with a Drug Enforcement Administration waiver in 2016 to prescribe buprenorphine for opioid use disorder in the U...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779543/geographic-variation-in-the-supply-of-selected-behavioral-health-providers
#19
C Holly A Andrilla, Davis G Patterson, Lisa A Garberson, Cynthia Coulthard, Eric H Larson
INTRODUCTION: In 2015, an estimated 43.4 million Americans aged 18 and older suffered from a behavioral health issue. Accurate estimates of the number of psychiatrists, psychologists, and psychiatric nurse practitioners are needed as demand for behavioral health care grows. METHODS: The National Plan and Provider Enumeration System National Provider Identifier data (October 2015) was used to examine the supply of psychiatrists, psychologists, and psychiatric nurse practitioners...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29778409/extensive-periosteal-new-bone-formation-in-a-skeleton-from-post-medieval-chichester-england-a-probable-case-of-metastatic-prostatic-carcinoma
#20
Carolyn Rando, Tony Waldron
An elderly male skeleton from a site in Chichester, UK, was found with a widespread periosteal reaction, principally affecting the axial skeleton and the pelvis. Radiography showed the presence of sclerosing infiltrates, mainly involving the lumbar vertebrae and pelvis. The differential diagnosis is discussed, reaching the conclusion that hypertrophic osteo-arthopathy (HOA) is the only reasonable alternative condition likely to produce such a widespread periosteal reaction as found here. HOA does not produce secondary deposits in the skeleton, however, and we conclude that his is most likely a case of prostatic carcinoma...
July 29, 2017: International Journal of Paleopathology
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