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https://www.readbyqxmd.com/read/28721804/-it-s-change-like-never-before
#1
Erin Dean
With Brexit, new roles and routes into nursing, changes to the student bursary in England, and draft standards for nursing education, there is a lot happening to affect nursing schools.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28720618/interpretation-of-cis-in-clinical-trials-with-non-significant-results-systematic-review-and-recommendations
#2
Jennifer S Gewandter, Michael P McDermott, Rachel A Kitt, Jenna Chaudari, James G Koch, Scott R Evans, Robert A Gross, John D Markman, Dennis C Turk, Robert H Dworkin
OBJECTIVES: Interpretation of CIs in randomised clinical trials (RCTs) with treatment effects that are not statistically significant can distinguish between results that are 'negative' (the data are not consistent with a clinically meaningful treatment effect) or 'inconclusive' (the data remain consistent with the possibility of a clinically meaningful treatment effect). This interpretation is important to ensure that potentially beneficial treatments are not prematurely abandoned in future research or clinical practice based on invalid conclusions...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28720613/retrospective-analysis-of-newly-recorded-certifications-of-visual-impairment-due-to-diabetic-retinopathy-in-wales-during-2007-2015
#3
Rebecca L Thomas, Stephen D Luzio, Rachel V North, Sanjiv Banerjee, Antra Zekite, Catey Bunce, David R Owens
OBJECTIVE: The aim of this study was to analyse the changes in new certifications for both sight impairment (SI) and severe sight impairment (SSI, blindness) in Wales due to diabetic retinopathy (DR)/maculopathy between 2007 and 2015. RESEARCH DESIGN AND METHODS: This is a retrospective analysis of annual data of new certifications for visual impairment and blindness (Certificate of Vision Impairment) for England and Wales derived from the national database provided by the Certifications Office, Moorfields Eye Hospital, over a period of 8 years from 2007...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28720578/systematic-longitudinal-survey-of-invasive-escherichia-coli-in-england-demonstrates-a-stable-population-structure-only-transiently-disturbed-by-the-emergence-of-st131
#4
Teemu Kallonen, Hayley J Brodrick, Simon R Harris, Jukka Corander, Nicholas M Brown, Veronique Martin, Sharon J Peacock, Julian Parkhill
Escherichia coli associated with urinary tract infections and bacteremia has been intensively investigated, including recent work focusing on the virulent, globally disseminated, multidrug-resistant lineage ST131. To contextualize ST131 within the broader E. coli population associated with disease, we used genomics to analyze a systematic 11-yr hospital-based survey of E. coli associated with bacteremia using isolates collected from across England by the British Society for Antimicrobial Chemotherapy and from the Cambridge University Hospitals NHS Foundation Trust...
July 18, 2017: Genome Research
https://www.readbyqxmd.com/read/28720560/increase-in-life-expectancy-in-england-has-halted-new-figures-show
#5
Gareth Iacobucci
No abstract text is available yet for this article.
July 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28718304/the-role-of-surgery-in-low-grade-gliomas-do-timing-and-extent-of-resection-matter
#6
Hugues Duffau
Hugues Duffau is a Professor and Chairman of the Neurosurgery Department in the Montpellier University Medical Center and Head of the INSERM 1051 Team "plasticity of the central nervous system, human stem cells and glial tumors" at the Institute for Neurosciences of Montpellier (France). He is an expert in the awake cognitive neurosurgery of slow-growing brain tumors, such as low-grade gliomas, a routine which he has developed since 20 years. His fundamental approach is centered on the concepts of the brain connectomics and neuroplasticity, breaking with the traditional localizationist view of cerebral processing...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28711522/engaging-with-primary-schools-supporting-the-delivery-of-the-new-curriculum-in-evolution-and-inheritance
#7
REVIEW
Paula X Kover, Emily S Hogge
The official school regulator in England (OFSTED) recently reported that the delivery of science lessons has been significantly diminished in many primary schools. There is concern that the lack of good quality science in school can reduce the recruitment of young scientists, and the level of science literacy among the general public. We believe university scientists and undergraduate students can have a significant impact in the delivery of science in primary schools. However, a relatively small proportion of scientists engage with young children to improve curricular primary school science education...
July 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28710216/lag-time-for-retinoblastoma-in-the-uk-revisited-a-retrospective-analysis
#8
Marcus Posner, Adil Jaulim, Marina Vasalaki, Khadija Rantell, Mandeep S Sagoo, M Ashwin Reddy
OBJECTIVES: To explore current delays in diagnosis of retinoblastoma (Rb) and effect on outcome with comparison to a study from the 1990s. SETTING: Primary, secondary, tertiary care: majority from South of England. PARTICIPANTS: A retrospective analysis of 93 new referrals of sporadic (non-familial) Rb to a specialist Rb unit in London, UK from January 2006 to February 2014. PRIMARY AND SECONDARY OUTCOMES: International Intraocular Retinoblastoma Classification, lag times including parental delay and healthcare professional delay, patients requiring enucleation and requirement of adjuvant chemotherapy postenucleation (high-risk Rb)...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28709785/implementing-and-evaluating-a-telephone-based-centralized-maternity-care-coordination-program-for-pregnant-veterans-in%C3%A2-the-department-of-veterans-affairs
#9
Kristin M Mattocks, Judy Kuzdeba, Rebecca Baldor, Jose Casares, Lisa Lombardini, Megan R Gerber
PURPOSE: The purpose of this study was to develop and evaluate a comprehensive, telephonic maternity care coordination (MCC) program for all pregnant veterans enrolled for care at New England Department of Veterans Affairs (VA) facilities that comprise the Veterans Integrated Service Network 1. RESEARCH DESIGN: Telephone interviews were conducted with postpartum women veterans who had participated in the MCC program during their pregnancies. The program evaluation instrument assessed satisfaction and use of MCC services, prenatal education classes, and infant and maternal outcomes (e...
July 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28708324/ferrichrome-has-found-its-match-biomimetic-analogs-with-diversified-activity-map-discrete-microbial-targets
#10
Jenny Besserglick, Evgenia Olshvang, Agnieszka Szebesczyk, Joseph Englander, Dana Levinson, Yitzhak Hadar, Elzbieta Gumienna-Kontecka, Abraham Shanzer
Siderophores provide an established platform for studying molecular recognition principles in biological systems. Herein we describe the preparation of ferrichrome biomimetic analogs varying in length and polarity of the amino acid chain separating between the tripodal scaffold and the pendent FeIII chelating hydroxamic acid groups. Spectroscopic and potentiometric titrations determined their iron affinity to be within the range of efficient chelators. Microbial growth promotion and iron uptake studies were conducted on E...
July 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28698337/protocol-for-a-multicentre-randomised-feasibility-study-evaluating-the-impact-of-a-prognostic-model-for-management-of-blunt-chest-wall-trauma-patients-stumbl-trial
#11
Ceri Battle, Zoe Abbott, Hayley A Hutchings, Claire Oâ Neill, Sam Groves, Alan Watkins, Fiona E Lecky, Sally Jones, James Gagg, Richard Body, Philip A Evans
INTRODUCTION: A new prognostic model has been developed and externally validated, the aim of which is to assist in the management of the blunt chest wall trauma patient in the emergency department (ED). A definitive randomised controlled trial (impact trial) is required to assess the clinical and cost effectiveness of the new model before it can be accepted in clinical practice. The purpose of this trial is to assess the feasibility and acceptability of such a definitive trial and inform its design...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28697940/characterization-of-perioperative-contralateral-stroke-after-carotid-endarterectomy
#12
W Darrin Clouse, Emel A Ergul, Virendra I Patel, R Todd Lancaster, Glenn M LaMuraglia, Richard P Cambria, Mark F Conrad
OBJECTIVE: Contralateral stroke is an infrequent cause of perioperative stroke after carotid endarterectomy (CEA). Whereas the risks of ipsilateral stroke complicating CEA have been discriminated, factors that lead to contralateral stroke are poorly defined. The purpose of this study was to identify the risk of perioperative (30-day) contralateral stroke after CEA as well as predisposing preoperative and operative factors. Its specific effect on long-term survival was interrogated. METHODS: The Vascular Study Group of New England (VSGNE) was queried from April 1, 2003, to February 29, 2016, for all CEAs...
July 8, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28697372/history-politics-and-vulnerability-explaining-excess-mortality-in-scotland-and-glasgow
#13
D Walsh, G McCartney, C Collins, M Taulbut, G David Batty
OBJECTIVES: High levels of excess mortality (i.e. that not explained by deprivation) have been observed for Scotland compared with England & Wales, and especially for Glasgow in comparison with similar post-industrial cities such as Liverpool and Manchester. Many potential explanations have been suggested. Based on an assessment of these, the aim was to develop an understanding of the most likely underlying causes. Note that this paper distils a larger research report, with the aim of reaching wider audiences beyond Scotland, as the important lessons learnt are relevant to other populations...
July 8, 2017: Public Health
https://www.readbyqxmd.com/read/28697343/redefining-hormonal-therapy-for-advanced-prostate-cancer-results-from-the-latitude-and-chaarted-studies
#14
Eric J Small
Two papers published recently in the New England Journal of Medicine describe the utility of abiraterone acetate, an androgen biosynthesis inhibitor, in the early treatment of metastatic prostate cancer. In addition to establishing a new standard of care, these two articles pose a number of important questions for future investigation.
July 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28695187/infection-burden-in-total-hip-and-knee-arthroplasties-an-international-registry-based-perspective
#15
Bryan D Springer, September Cahue, Caryn D Etkin, David G Lewallen, Brian J McGrory
BACKGROUND: Infection remains a leading cause of failure of hip and knee replacements. Infection burden is the ratio of implants revised for infection to the total number of arthroplasties in a specific period, measuring the steady state of infection in a registry. We hypothesized infection burden would be similar among arthroplasty registries. METHODS: We evaluated publicly reported data from 6 arthroplasty registries (Australian Orthopaedic Association National Joint Replacement Registry [AOANJRR], New Zealand Joint Registry, Swedish Hip Arthroplasty Register, Swedish Knee Arthroplasty Register, National Joint Registry of England, Wales, Northern Ireland, and the Isle of Man, and the American Joint Replacement Registry) for revisions performed with an infection diagnosis over the last 6 years...
June 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28689764/wula-voices-of-aboriginal-women-on-barriers-to-accepting-smoking-cessation-support-during-pregnancy-findings-from-a-qualitative-study
#16
M Bovill, M Gruppetta, Y Cadet-James, M Clarke, B Bonevski, G S Gould
AIM: To gather Aboriginal women's stories of smoking and becoming pregnant to identify the barriers in accepting smoking cessation support during pregnancy. METHODS: Qualitative data were collected through use of yarning methodology between August 2015 and January 2016 by an Aboriginal Researcher with experience in social and community services. A short on-line survey was used to collect quantitative data. Interviews only recorded the therapeutic yarning process, which ranged from 9 to 45min duration, averaging 30min...
July 6, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28688539/us-regional-and-demographic-differences-in-prescription-opioid-and-heroin-related-overdose-hospitalizations
#17
George Jay Unick, Daniel Ciccarone
BACKGROUND: US opioid overdose death rates have increased between 2000 and 2014. While, the increase in prescription opioid use has been linked to the increase in heroin use, there are reasons to view this relationship as a partial explanation for the recent increase in heroin-related harms. This study documents the differences in trends in prescription opioid overdose-related (POD) and heroin overdose-related (HOD) hospitalizations. METHODS: Data come from the National Inpatient Sample (NIS) for the years 2000 through 2014...
July 5, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28682130/the-front-line-general-surgery-consultant-as-a-new-model-of-emergency-care
#18
A P Navarro, Ejo Hardy, B Oakley, E Mohamed, N T Welch, S L Parsons
INTRODUCTION Emergency general surgery services in England are undergoing rapid structural change with the aim of improving care. In our centre, the key issues identified were high numbers of admissions, inappropriate referrals, prolonged waiting times, delayed senior input and poor patient satisfaction. A new model was launched in January 2015 to address these issues: the surgical triage unit (STU). This study assesses the success of the new service. METHODS All emergency general surgical admissions during a five-month period before introduction of the STU were compared with those of a comparable five-month period after its introduction...
July 6, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28679538/the-intervention-effect-of-local-alcohol-licensing-policies-on-hospital-admission-and-crime-a-natural-experiment-using-a-novel-bayesian-synthetic-time-series-method
#19
Frank de Vocht, Kate Tilling, Triantafyllos Pliakas, Colin Angus, Matt Egan, Alan Brennan, Rona Campbell, Matthew Hickman
BACKGROUND: Control of alcohol licensing at local government level is a key component of alcohol policy in England. There is, however, only weak evidence of any public health improvement. We used a novel natural experiment design to estimate the impact of new local alcohol licensing policies on hospital admissions and crime. METHODS: We used Home Office licensing data (2007-2012) to identify (1) interventions: local areas where both a cumulative impact zone and increased licensing enforcement were introduced in 2011; and (2) controls: local areas with neither...
July 5, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28678600/discussing-the-predictive-prognostic-and-therapeutic-value-of-germline-dna-repair-gene-mutations-in-metastatic-prostate-cancer-patients
#20
Ralph J Hauke, Tristan M Sissung, William D Figg
Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the New England Journal of Medicine found that patients with metastatic prostate cancer presented germline mutations in DNA-repair genes at a significantly higher incidence than those with localized prostate cancer...
July 5, 2017: Cancer Biology & Therapy
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