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JOURNAL ARTICLE
D P Knobles, Tracianne B Neilsen, William S Hodgkiss, John A Goff
An ocean acoustics experiment in 2017 near a shipping lane on the New England continental shelf in about 75 m of water provided an opportunity to evaluate a methodology to extract source signatures of merchant ships in a bottom-limited environment. The data of interest are the received acoustic levels during approximately 20 min time intervals centered at the closest position of approach (CPA) time for each channel on two 16-element vertical line arrays. At the CPA ranges, the received levels exhibit a frequency-dependent peak and null structure, which possesses information about the geophysical properties of the seabed, such as the porosity and sediment thickness, and the characterization of the source, such as an effective source depth...
May 1, 2024: Journal of the Acoustical Society of America
#2
JOURNAL ARTICLE
Matthew Fell, Ginette Phippen, Stephanie van Eeden, David Chong, Marc C Swan, Simon van Eeden, John B Carlin
The Timing of Primary Surgery (TOPS) trial was published August 2023 in the New England Journal of Medicine and is a milestone achievement for a study focused on cleft palate. Due to the complexity of outcome reporting in cleft and the rarity of such comparative trials, TOPS presents a useful opportunity to critically review the design, analysis and reporting strategies utilised. This perspective article focused on the inclusion of participants, the choice of the primary outcome measure and the analysis of ordinal data within the trial...
May 9, 2024: Cleft Palate-craniofacial Journal
#3
JOURNAL ARTICLE
Emma Rezel-Potts, Catherine Bowen, Kate M Dunn, Christopher I Jones, Martin C Gulliford, Stewart C Morrison
The aim of this research was to describe the epidemiology, presentation and healthcare use in primary care for foot and ankle problems in children and young people (CYP) across England. We undertook a population-based cohort study using data from the Clinical Practice Research Datalink Aurum database, a database of anonymised electronic health records from general practices across England. Data was accessed for all CYP aged 0-18 years presenting to their general practitioner between January 2015 and December 2021 with a foot and/or ankle problem...
May 9, 2024: European Journal of Pediatrics
#4
JOURNAL ARTICLE
Christine Andrews, Michael Herzlinger, Muhammad Riaz, Enju Liu, Christina Chan, Silvana Bonilla
OBJECTIVES: Helicobacter pylori rates of eradication to common first-line regimens continue to decline globally. Prescription of the appropriate medication dosage is an important consideration, particularly in the pediatric population due to medication weight-based dosing. Limited data is available on the impact of guideline-recommended weight-based dosing on the successful eradication of H. pylori in children. METHODS: Retrospective study of patients with histologic evidence of H...
May 8, 2024: Journal of Pediatric Gastroenterology and Nutrition
#5
JOURNAL ARTICLE
Thomas Beaney, Sneha Jha, Asem Alaa, Alexander Smith, Jonathan Clarke, Thomas Woodcock, Azeem Majeed, Paul Aylin, Mauricio Barahona
OBJECTIVE: Natural language processing (NLP) algorithms are increasingly being applied to obtain unsupervised representations of electronic health record (EHR) data, but their comparative performance at predicting clinical endpoints remains unclear. Our objective was to compare the performance of unsupervised representations of sequences of disease codes generated by bag-of-words versus sequence-based NLP algorithms at predicting clinically relevant outcomes. MATERIALS AND METHODS: This cohort study used primary care EHRs from 6 286 233 people with Multiple Long-Term Conditions in England...
May 8, 2024: Journal of the American Medical Informatics Association: JAMIA
#6
JOURNAL ARTICLE
Sam Halabi, Lawrence O Gostin, Olohikhuae Egbokhare, Matthew M Kavanagh
No abstract text is available yet for this article.
May 8, 2024: New England Journal of Medicine
#7
JOURNAL ARTICLE
Christopher T Doughty, Pamela W Schaefer, Kate Brizzi, Jenny J Linnoila
New England Journal of Medicine, Volume 390, Issue 18, Page 1712-1719, May 9, 2024.
May 9, 2024: New England Journal of Medicine
#8
JOURNAL ARTICLE
Kaito Aoki, Marenori Kojima
New England Journal of Medicine, Volume 390, Issue 18, Page 1711-1711, May 9, 2024.
May 9, 2024: New England Journal of Medicine
#9
REVIEW
Josephine M Egan
New England Journal of Medicine, Volume 390, Issue 18, Page 1699-1710, May 9, 2024.
May 9, 2024: New England Journal of Medicine
#10
JOURNAL ARTICLE
Pavan K Bendapudi, Brody H Foy, Sarah B Mueller, Jun Liu, Louis M Feingold, Kristen E Burke, Wendy Cruz, Maria Y Chen, Emily S Lau, Rachel L Goldberg, Ishan Tatake, Shelby C Wilkinson, Brian J Carney, James R Stone, Doyun Park, Alzira R Avelino, Sajjad Hassan, Chester Andrzejewski, Kristen N Ruby, Kenneth D Friedman, Patricia A R Brunker, Rebecca K Leaf, John Higgins, Walter H Dzik, Jonathan A Stefely, Robert S Makar
In patients with immune thrombotic thrombocytopenic purpura (iTTP), autoantibodies against the metalloprotease ADAMTS13 lead to catastrophic microvascular thrombosis. However, the potential benefits of recombinant human ADAMTS13 (rADAMTS13) in patients with iTTP remain unknown. Here, we report the clinical use of rADAMTS13, which resulted in the rapid suppression of disease activity and complete recovery in a critically ill patient whose condition had proved to be refractory to all available treatments. We also show that rADAMTS13 causes immune complex formation, which saturates the autoantibody and may promote its clearance...
May 9, 2024: New England Journal of Medicine
#11
RANDOMIZED CONTROLLED TRIAL
Vincent Costalat, Tudor G Jovin, J F Albucher, Christophe Cognard, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sebastien Richard, Gaultier Marnat, Igor Sibon, Federico Di Maria, Mariam Annan, Grégoire Boulouis, Pere Cardona, Michael Obadia, Michel Piotin, Romain Bourcier, Benoit Guillon, Sophie Godard, Anne Pasco-Papon, Omer F Eker, Tae-Hee Cho, Guillaume Turc, Olivier Naggara, Stéphane Velasco, Matthias Lamy, Frédéric Clarençon, Sonia Alamowitch, Arturo Renu, Laurent Suissa, Hervé Brunel, Jean-Christophe Gentric, Serge Timsit, Chantal Lamy, Cyril Chivot, Francisco Macian-Montoro, Charbel Mounayer, Ozlem Ozkul-Wermester, Chrysanthi Papagiannaki, Valérie Wolff, Raoul Pop, Anna Ferrier, Emmanuel Chabert, Frédéric Ricolfi, Yannick Béjot, Elena Lopez-Cancio, Pedro Vega, Laurent Spelle, Christian Denier, Mònica Millán, Juan F Arenillas, Mikael Mazighi, Emmanuel Houdart, Maria Del Mar Freijo, Alain Duhamel, Nerses Sanossian, David S Liebeskind, Julien Labreuche, Bertrand Lapergue, Caroline Arquizan
BACKGROUND: The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied. METHODS: We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusion in the anterior circulation and a large infarct (as defined by an Alberta Stroke Program Early Computed Tomographic Score of ≤5; values range from 0 to 10) detected on magnetic resonance imaging or computed tomography within 6.5 hours after symptom onset to undergo endovascular thrombectomy and receive medical care (thrombectomy group) or to receive medical care alone (control group)...
May 9, 2024: New England Journal of Medicine
#12
JOURNAL ARTICLE
Jane Pritchard, Ruth Bartlett
Hope is an important but overlooked phenomenon in dementia studies. Few studies have examined how people with dementia experience or perceive hope, possibly because it is seen as a diagnosis without hope. In this article, we report on a doctoral study, the aim of which was to examine the phenomenon of hope from the perspective of younger people with dementia to generate new understanding and enable community-based healthcare professionals to support well-being. The study was conducted in the Midlands, England, and used a modified diary-interview method...
May 7, 2024: Dementia
#13
JOURNAL ARTICLE
Eric A Pierce, Tomas S Aleman, Kanishka T Jayasundera, Bright S Ashimatey, Keunpyo Kim, Alia Rashid, Michael C Jaskolka, Rene L Myers, Byron L Lam, Steven T Bailey, Jason I Comander, Andreas K Lauer, Albert M Maguire, Mark E Pennesi
BACKGROUND: CEP290 -associated inherited retinal degeneration causes severe early-onset vision loss due to pathogenic variants in CEP290 . EDIT-101 is a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) gene-editing complex designed to treat inherited retinal degeneration caused by a specific damaging variant in intron 26 of CEP290 (IVS26 variant). METHODS: We performed a phase 1-2, open-label, single-ascending-dose study in which persons 3 years of age or older with CEP290 -associated inherited retinal degeneration caused by a homozygous or compound heterozygous IVS26 variant received a subretinal injection of EDIT-101 in the worse (study) eye...
May 6, 2024: New England Journal of Medicine
#14
JOURNAL ARTICLE
Lucy E Geraghty, Emma A Dunne, Caitríona M Ní Chathasaigh, Akke Vellinga, Niamh C Adams, Eoin M O'Currain, Lisa K McCarthy, Colm P F O'Donnell
BACKGROUND: Repeated attempts at endotracheal intubation are associated with increased adverse events in neonates. When clinicians view the airway directly with a laryngoscope, fewer than half of first attempts are successful. The use of a video laryngoscope, which has a camera at the tip of the blade that displays a view of the airway on a screen, has been associated with a greater percentage of successful intubations on the first attempt than the use of direct laryngoscopy in adults and children...
May 5, 2024: New England Journal of Medicine
#15
REVIEW
Rose Smith, Molly Davey
The anaesthetic training programme in the United Kingdom (UK) spans over seven years and is overseen by the Royal College of Anaesthetists (RCOA). Junior doctors in England are currently striking amid ongoing pay negotiations with the government, and almost all junior doctors are worried about the cost of living. This article provides an overview of the average financial cost of training for doctors in the anaesthetic training programme. The cost incurred by anaesthetic trainees illustrates the level of financial burden faced by trainees across multiple specialities...
April 30, 2024: British Journal of Hospital Medicine
#16
JOURNAL ARTICLE
Matiar Madanchi, Peter Itin
New England Journal of Medicine, Volume 390, Issue 18, May 9, 2024.
May 4, 2024: New England Journal of Medicine
#17
JOURNAL ARTICLE
Tessa Adžemović
New England Journal of Medicine, Volume 390, Issue 18, Page 1645-1647, May 9, 2024.
May 4, 2024: New England Journal of Medicine
#18
JOURNAL ARTICLE
Ahmad El-Hellani, Theodore L Wagener, Marielle C Brinkman
New England Journal of Medicine, Volume 390, Issue 18, Page 1639-1641, May 9, 2024.
May 4, 2024: New England Journal of Medicine
#19
JOURNAL ARTICLE
Anna Seeley, Margaret Glogowska, Gail Hayward
BACKGROUND: Around 15% of adults aged over 65 live with moderate or severe frailty. Contractual requirements for management of frailty are minimal and neither incentivised nor reinforced. Previous research has shown frailty identification in primary care is ad hoc and opportunistic, but there has been little focus on the challenges of frailty management, particularly within the context of recent introduction of primary care networks and an expanding allied health professional workforce...
May 1, 2024: Age and Ageing
#20
JOURNAL ARTICLE
Oleg A Godin, Tsu Wei Tan, John E Joseph, Matthew W Walters
Knowledge of near-bottom ocean current velocities and especially their extreme values is necessary to understand geomorphology of the seafloor and composition of benthic biological communities and quantify mechanical energy dissipation by bottom drag. Direct measurements of near-bottom currents in deep ocean remain scarce because of logistical challenges. Here, we report the results of flow velocity and pressure fluctuation measurements at three sites with depths of 2573-4443 m in the area where the Gulf Stream interacts with the New England Seamounts...
May 5, 2024: Scientific Reports
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