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https://www.readbyqxmd.com/read/29684086/frequency-of-appearance-of-transverse-harris-lines-reflects-living-conditions-of-the-pleistocene-bear-ursus-ingressus-sudety-mts-poland
#1
Dariusz Nowakowski
Transverse lines, called Harris Lines (HL), osteological markers of recovery from growth arrest episodes, are visible in radiograms of recent and Pleistocene fossil bones. Since on the one hand they mark stressful episodes in life, and on the other are mainly used to trace health fluctuations in prehistoric human communities, I used a cave bear population to check if the processes that could affect the specie' condition were in any way reflected in the bone structure. 392 bear bones from Bear Cave in Kletno (collection: Department of Palaeozoology, University of Wrocław), dated as 32 100 ±1300 to >49 000 years BP, were radiologically examined...
2018: PloS One
https://www.readbyqxmd.com/read/29683096/novel-anthraquinone-derivatives-as-dual-inhibitors-of-topoisomerase-2-and-casein-kinase-2-in-silico-studies-synthesis-and-biological-evaluation-on-leukemic-cell-lines
#2
Abbas Kabir, Kalpana Tilekar, Neha Upadhyay, C S Ramaa
Background - Cancer being a complex disease, single targeting agents remains unsuccessful. This calls for "multiple targeting", wherein a single drug is so designed that it will modulate the activity of multiple protein targets. Topoisomerase 2 (Top2) helps in removing DNA tangles and super-coiling during cellular replication, Casein Kinase 2 (CK2) is involved in the phosphorylation of multitude of protein targets. Thus, in the present work, we have tried to develop dual inhibitors of Top2 and CK2...
April 22, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29681481/predictors-of-hypothyroidism-in-hodgkin-lymphoma-survivors-after-intensity-modulated-versus-3-dimensional-radiation-therapy
#3
Chelsea C Pinnix, Laura Cella, Therese Y Andraos, Zeina Ayoub, Sarah A Milgrom, Jillian Gunther, Sonali Thosani, Christine Wogan, Manuel Conson, Vittoria D'Avino, Yasuhiro Oki, Michelle Fanale, Hun J Lee, Sattva Neelapu, Luis Fayad, Frederick Hagemeister, M Alma Rodriguez, Loretta J Nastoupil, Yago Nieto, Wei Qiao, Roberto Pacelli, Bouthaina Dabaja
PURPOSE: To identify predictors of hypothyroidism after chemoradiation therapy for Hodgkin lymphoma (HL) and to compare outcomes after intensity modulated radiation therapy (IMRT) with those after 3-dimensional (3D) conformal radiation therapy (CRT). METHODS AND MATERIALS: Ninety patients who underwent involved-site IMRT in 2009 through 2014 were evaluated for treatment-induced hypothyroidism, defined as elevated thyroid-stimulating hormone or decreased free thyroxine levels (or both)...
March 14, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29679536/curcumin-formulated-in-solid-lipid-nanoparticles-has-enhanced-efficacy-in-hodgkin-s-lymphoma-in-mice
#4
Jacob Guorgui, Ruixue Wang, George Mattheolabakis, Gerardo G Mackenzie
Curcumin reduces Hodgkin's lymphoma (HL) cell growth in vitro, but its unfavorable pharmacokinetics highlight the need for novel in vivo delivery systems. Thus, we explored whether formulation of curcumin in solid lipid nanoparticles (SLN-curc) or d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoparticles (TPGS-curc) could enhance its efficacy in mice. Curcumin formulated in SLN and in TPGS resulted in higher curcumin plasma levels in mice. Compared to vehicle-treated controls, SLN-curc and TPGS-curc reduced HL xenograft growth by 50...
April 18, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29678410/health-literacy-in-children-with-asthma-a-systematic-review
#5
REVIEW
Yu-Fen Tzeng, Bor-Luen Chiang, Yu-Hsia Chen, Bih-Shya Gau
Health literacy (HL) is a key factor influencing asthma management outcomes and has primarily been focused on adult patients. The relationship between children's HL and asthma is unclear, and several research gaps are present in the direct assessment of children's HL. In this study, a systematic review of the relevant literature was conducted to elucidate the relationship between HL and asthma among children. An electronic database search was performed to obtain studies published between January 2005-August 2016...
December 8, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29677913/implementation-of-fast-healthcare-interoperability-resources-for-an-integration-of-laboratory-and-hospital-information-systems
#6
Georgy Kopanitsa, Alexandr Ivanov
Electronic exchange of medical data between clinics and test centers makes the testing process more efficient, enables continuity of care record and reuse of medical data. The presented project employs HL 7 FHIR approach to model clinical concepts for the medical data exchange between a test center and different hospitals. Using a standard FHIR editor we have modeled 1226 observation profiles, 2396 commercial tests profiles that are mapped to 3249 production tests profiles. We have also defined a concept of an order and developed RESTfull API protocol to facilitate the ordering process...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29675840/outcome-of-children-with-newly-diagnosed-acute-lymphoblastic-leukemia-treated-with-cclg-all-2008-the-first-nation-wide-prospective-multicenter-study-in-china
#7
Lei Cui, Zhi-Gang Li, Yi-Huan Chai, Jie Yu, Ju Gao, Xiao-Fan Zhu, Run-Ming Jin, Xiao-Dong Shi, Le-Ping Zhang, Yi-Jin Gao, Rui-Dong Zhang, Hu-Yong Zheng, Shao-Yan Hu, Ying-Hui Cui, Yi-Ping Zhu, Yao Zou, Margaret Hl Ng, Yan Xiao, Jun-Hui Li, Yong-Hong Zhang, Hai-Long He, Ying Xian, Tian-You Wang, Chi-Kong Li, Min-Yuan Wu
Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recruited from ten tertiary hospitals in eight cities. The patients were stratified according to clinical-biological characteristics and early treatment response. Standard risk (SR) and intermediate risk (IR) groups were treated with a modified BFM based protocol, and there was 25-50% dose reduction during intensification phases in the SR group...
April 20, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29675740/identification-of-poly-n-acetyllactosamine-carrying-glycoproteins-from-hl-60-human-promyelocytic-leukemia-cells-using-a-site-specific-glycome-analysis-method-glyco-ridge
#8
Akira Togayachi, Azusa Tomioka, Mika Fujita, Masako Sukegawa, Erika Noro, Daisuke Takakura, Michiyo Miyazaki, Toshihide Shikanai, Hisashi Narimatsu, Hiroyuki Kaji
To elucidate the relationship between the protein function and the diversity and heterogeneity of glycans conjugated to the protein, glycosylation sites, glycan variation, and glycan proportions at each site of the glycoprotein must be analyzed. Glycopeptide-based structural analysis technology using mass spectrometry has been developed; however, complicated analyses of complex spectra obtained by multistage fragmentation are necessary, and sensitivity and throughput of the analyses are low. Therefore, we developed a liquid chromatography/mass spectrometry (MS)-based glycopeptide analysis method to reveal the site-specific glycome (Glycan heterogeneity-based Relational IDentification of Glycopeptide signals on Elution profile, Glyco-RIDGE)...
April 19, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29671791/the-antecedents-and-consequences-of-health-literacy-in-an-ecological-perspective-results-from-an-experimental-analysis
#9
Chiara Lorini, Francesca Ierardi, Letizia Bachini, Martina Donzellini, Fabrizio Gemmi, Guglielmo Bonaccorsi
This study analyses the relationship between the antecedents and consequences of health literacy (HL) at the ecological level among the nations involved in the European Health Literacy Survey (HLS-EU). The antecedents and consequences were investigated by means of proxy indicators. The HL was measured using the 47-item HLS-EU questionnaire (HLS-EUQ47) and the Newest Vital Sign (NVS). The two measures stood in significant correlation to the outcomes of the sub-discipline of the Euro Health Consumer Index (r = 0...
April 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29670243/nivolumab-effective-in-treatment-resistant-hl
#10
(no author information available yet)
No abstract text is available yet for this article.
April 18, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29668300/magnitude-of-cone-beam-computed-tomography-image-artifacts-related-to-zirconium-and-titanium-implants-impact-on-image-quality
#11
Rocharles C Fontenele, Eduarda Hl Nascimento, Taruska V Vasconcelos, Marcel Noujeim, Deborah Q Freitas
OBJECTIVES: To evaluate the magnitude of artifacts related to titanium and zirconium implants at different distances and angulations and their impact on cone beam computed tomography (CBCT) image quality. METHODS: CBCT images were obtained before and after the insertion of titanium and zirconium implants in a mandible on different CBCT units: Picasso Trio, ProMax 3D and 3D Accuitomo 80. Artefact was assessed by measuring the standard deviation of gray values (SD) and contrast-to-noise ratio (CNR) of 11 regions of interest (ROI) at different distances (1...
April 18, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29667419/furanocoumarins-with-potential-antiproliferative-activities-from-clausena-lenis
#12
Yan-Ping Liu, Qing Wen, Shi Hu, Yan-Lei Ma, Zhi-Hua Jiang, Jin-Ying Tang, Yan-Hui Fu, Shen-Xiang Qiu
A phytochemical investigation on the stems and leaves of Clausena lenis led to the isolation of a new furanocoumarin, clauselenisin A (1), together with five known analogues (2-6). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2-6) were isolated from C. lenis for the first time. All isolated compounds were evaluated for their their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29664890/health-literacy-and-quality-of-physician-trauma-patient-communication-opportunity-for-improvement
#13
Jonathan L Dameworth, Jordan A Weinberg, Pamela W Goslar, Dana J Stout, Sharjeel Israr, Jordan V Jacobs, Thomas L Gillespie, Terrell M Thompson, Scott R Petersen
BACKGROUND: Although physician-patient communication and health literacy (HL) have been studied in diverse patient groups, there has been little focus on trauma patients. A quality improvement project was undertaken at our level 1 trauma center to improve patient perception of physician-patient communication, with consideration of the effect of HL. We report the first phase of this project, namely the reference level of satisfaction with physician-patient communication as measured by levels of interpersonal care among patients at an urban level 1 trauma center...
April 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29664867/short-and-long-term-outcomes-of-titanium-clip-ossiculoplasty
#14
Charissa N Kahue, Brendan P O'Connnell, Matthew M Dedmon, David S Haynes, Alejandro Rivas
OBJECTIVE: To report short (∼4 mo) and long-term (>12 mo) audiometric outcomes following ossiculoplasty using a titanium clip partial ossicular reconstruction prosthesis. METHODS: Case series at a single tertiary referral center reviewing 130 pediatric and adult patients with conductive hearing loss (CHL) secondary to chronic otitis media (n = 121, 93%) or traumatic ossicular disruption (n = 9, 7%) who underwent partial ossiculoplasty from January 2005 to December 2015 with the CliP prosthesis...
April 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29664150/conductive-hearing-loss-in-four-dogs-associated-with-the-use-of-ointment-based-otic-medications
#15
Lynette K Cole, Päivi J Rajala-Schultz, Gwendolen Lorch
BACKGROUND: Hearing loss (HL) is classified as conductive when sound transmission is compromised in the ear canal or middle ear, or sensorineural when there is an abnormality of the receptor cells of the cochlea or auditory pathway. Hearing in dogs is evaluated using the brainstem auditory evoked response (BAER) test. HYPOTHESIS/OBJECTIVES: Our objective was to characterize BAER findings pre- and post-ear flushing in four dogs with acute HL following application of an ointment-based otic medication containing betamethasone, clotrimazole and gentamicin in a mineral oil-based system containing a plasticized hydrocarbon gel...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29663358/a-case-control-study-of-hiv-infection-and-cancer-in-the-era-of-antiretroviral-therapy-in-rwanda
#16
Tharcisse Mpunga, Ariana Znaor, F Regis Uwizeye, Aline Uwase, Cyprien Munyanshongore, Silvia Franceschi, Gary M Clifford
The aim of our study was to assess the association between HIV infection and cancer risk in Rwanda approximately a decade after the introduction of antiretroviral therapy (cART). All persons seeking cancer care at Butaro Cancer Center of Excellence (BCCOE) in Rwanda from 2012 to 2016 were routinely screened for HIV, prior to being confirmed with or without cancer (cases and controls, respectively). Cases were coded according to ICD-O-3 and converted to ICD10. Associations between individual cancer types and HIV were estimated using adjusted unconditional logistic regression...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29663100/quinazoline-clubbed-1-3-5-triazine-derivatives-as-vegfr2-kinase-inhibitors-design-synthesis-docking-in-vitro-cytotoxicity-and-in-ovo-antiangiogenic-activity
#17
Prateek Pathak, Parjanya Kumar Shukla, Vikas Kumar, Ankit Kumar, Amita Verma
A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line HFF (human foreskin fibroblasts). In vitro assay result encouraged to further move towards in ovo anticancer evaluation using chick embryo. The series of QCT derivatives showed higher anticancer and antiangiogenic activity against HeLa and MCF-7 cell lines...
April 16, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29663099/feasibility-study-of-stain-free-classification-of-cell-apoptosis-based-on-diffraction-imaging-flow-cytometry-and-supervised-machine-learning-techniques
#18
Jingwen Feng, Tong Feng, Chengwen Yang, Wei Wang, Yu Sa, Yuanming Feng
This study was to explore the feasibility of prediction and classification of cells in different stages of apoptosis with a stain-free method based on diffraction images and supervised machine learning. Apoptosis was induced in human chronic myelogenous leukemia K562 cells by cis-platinum (DDP). A newly developed technique of polarization diffraction imaging flow cytometry (p-DIFC) was performed to acquire diffraction images of the cells in three different statuses (viable, early apoptotic and late apoptotic/necrotic) after cell separation through fluorescence activated cell sorting with Annexin V-PE and SYTOX® Green double staining...
April 16, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29662618/ectopic-expression-of-transcription-factor-batf3-induces-b-cell-lymphomas-in-a-murine-b-cell-transplantation-model
#19
Christian Weiser, Mina V Petkova, Benjamin Rengstl, Claudia Döring, Dorothee von Laer, Sylvia Hartmann, Ralf Küppers, Martin-Leo Hansmann, Sebastian Newrzela
The mechanisms involved in malignant transformation of mature B and T lymphocytes are still poorly understood. In a previous study, we compared gene expression profiles of the tumor cells of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) to their normal cellular counterparts and found the basic leucine zipper protein ATF-like 3 (BATF3) to be significantly upregulated in the tumor cells of both entities. To assess the oncogenic potential of BATF3 in lymphomagenesis and to dissect the molecular interactions of BATF3 in lymphoma cells, we retrovirally transduced murine mature T and B cells with a BATF3-encoding viral vector and transplanted each population into Rag1-deficient recipients...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661730/distribution-of-lymphoid-neoplasms-in-northwest-china-analysis-of-3244-cases-according-to-who-classification-in-a-single-institution
#20
Chun Cao, Juan Feng, Hongtao Gu, Hailong Tang, Li Xu, Hongjuan Dong, Baoxia Dong, Mimi Shu, Qingxian Bai, Rong Liang, Tao Zhang, Lan Yang, Zhe Wang, Xiequn Chen, Guangxun Gao
To explore the distribution of lymphoid neoplasms in Northwest China, the clinical and pathological data of lymphoma patients from 2006 to 2014 were analyzed according to the WHO classification in Xijing Hospital. Of the 3244 cases, mature B-cell neoplasms occupied 60.7%, while mature T/NK-cell neoplasms and Hodgkin's lymphomas (HL) occupied 26.2% and 8.1%, respectively. The most common subtype of lymphoma was diffuse large B-cell lymphoma (35.0%), followed by extranodal NK/T-cell lymphoma, nasal type (ENKTCL) (12...
May 12, 2017: Annals of Diagnostic Pathology
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