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https://www.readbyqxmd.com/read/29456968/alternative-splicing-of-differentiated-myeloid-cell-transcripts-after-infection-by-anaplasma-phagocytophilum-impacts-a-selective-group-of-cellular-programs
#1
J Stephen Dumler, Sara H Sinclair, Amol C Shetty
Eukaryotic proteome diversity exceeds that encoded within individual genes, and results in part from alternative splicing events of pre-messenger RNA. The diversity of these splicing events can shape the outcome in development and differentiation of normal tissues, and is important in pathogenic circumstances such as cancer and some heritable conditions. A role for alternative splicing of eukaryotic genes in response to viral and intracellular bacterial infections has only recently been recognized, and plays an important role in providing fitness for microbial survival, while potentially enhancing pathogenicity...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29456149/impact-of-a-universal-medication-schedule-on-rationalising-and-understanding-of-medication-a-randomised-controlled-trial
#2
Eimear McManus, Suzanne McCarthy, Raymond Carson, Laura J Sahm
BACKGROUND: Patients frequently encounter difficulty understanding their prescription drug labels. This problem is more common in patients with limited health literacy (HL). Patients are not always counselled on their medicines by their doctor or pharmacist, therefore this label can be an important source of information. OBJECTIVE: To assess the impact of a Universal Medication Schedule (UMS) on the knowledge and consolidation of a prescription drug regimen compared to standard pharmacy labelling...
February 10, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29454918/design-synthesis-and-biological-evaluation-of-novel-amide-and-hydrazide-based-thioether-analogs-targeting-histone-deacteylase-hdac-enzymes
#3
Ayman B Farag, Heba A Ewida, Mahmoud Salama Ahmed
Development of HDAC inhibitors have become an ultimate need targeting different types of cancer. In silico virtual screening was applied to screen novel scaffolds via scaffold hopping strategy to develop different acrylamide and aryl/heteroaryl hydrazide based analogs merged with thioether moiety. The acrylamide based analogs showed significant hydrophobic interaction within binding pocket in addition to co-ordination with Zn+2 via carbonyl group, however the aryl/heteroaryl hydrazide based analogs showed binding towards Zn+2 via thiol moiety...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29454914/substituting-one-paris-for-another-in-vitro-cytotoxic-and-in-vivo-antitumor-activities-of-paris-forrestii-a-substitute-of-paris-polyphylla-var-yunnanensis
#4
Yue-Hu Wang, Min Shi, Hong-Mei Niu, Jun Yang, Meng-Yuan Xia, Ji-Feng Luo, Ying-Jie Chen, Yi-Ping Zhou, Heng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Chong-lou (Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis) is traditionally used as an anticancer medicine in China. It is also the material basis of some Chinese patent anticancer medicines, such as Gan-Fu-Le capsules, Bo-Er-Ning capsules, Lou-Lian capsules, Ruan-Jian oral liquid, and Qi-Zhen capsules. P. forrestii, a substitute for Chong-lou, is planted at a large scale in the Yunnan Province of China. AIM OF THE STUDY: To clarify the active chemical constituents of P...
February 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29451393/cleaning-at-home-and-at-work-in-relation-to-lung-function-decline-and-airway-obstruction
#5
Øistein Svanes, Randi J Bertelsen, Stein Hl Lygre, Anne E Carsin, Josep M Antó, Bertil Forsberg, José M García-García, José A Gullón, Joachim Heinrich, Mathias Holm, Manolis Kogevinas, Isabel Urrutia, Bénédicte Leynaert, Jesús M Moratalla, Nicole Le Moual, Theodore Lytras, Dan Norbäck, Dennis Nowak, Mario Olivieri, Isabelle Pin, Nicole Probst-Hensch, Vivi Schlünssen, Torben Sigsgaard, Trude D Skorge, Simona Villani, Debbie Jarvis, Jan P Zock, Cecilie Svanes
RATIONALE: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. The long-term consequences of cleaning agents on respiratory health are, however, not well described. OBJECTIVES: This paper aims to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and chronic airway obstruction...
February 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29451107/bilaterally-combined-electric-and-acoustic-hearing-in-mandarin-speaking-listeners-the-population-with-poor-residual-hearing
#6
Duo-Duo Tao, Ji-Sheng Liu, Zhen-Dong Yang, Blake S Wilson, Ning Zhou
The hearing loss criterion for cochlear implant candidacy in mainland China is extremely stringent (bilateral severe to profound hearing loss), resulting in few patients with substantial residual hearing in the nonimplanted ear. The main objective of the current study was to examine the benefit of bimodal hearing in typical Mandarin-speaking implant users who have poorer residual hearing in the nonimplanted ear relative to those used in the English-speaking studies. Seventeen Mandarin-speaking bimodal users with pure-tone averages of ∼80 dB HL participated in the study...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29449298/clinical-validation-of-a-public-health-policy-making-platform-for-hearing-loss-evotion-protocol-for-a-big-data-study
#7
Giorgos Dritsakis, Dimitris Kikidis, Nina Koloutsou, Louisa Murdin, Athanasios Bibas, Katherine Ploumidou, Ariane Laplante-Lévesque, Niels Henrik Pontoppidan, Doris-Eva Bamiou
INTRODUCTION: The holistic management of hearing loss (HL) requires an understanding of factors that predict hearing aid (HA) use and benefit beyond the acoustics of listening environments. Although several predictors have been identified, no study has explored the role of audiological, cognitive, behavioural and physiological data nor has any study collected real-time HA data. This study will collect 'big data', including retrospective HA logging data, prospective clinical data and real-time data via smart HAs, a mobile application and biosensors...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29448858/long-term-results-of-the-aieop-mh-96-childhood-hodgkin-s-lymphoma-trial-and-focus-on-significance-of-response-to-chemotherapy-and-its-implication-in-low-risk-patients-to-avoid-radiotherapy
#8
Roberta Burnelli, Simona Rinieri, Roberto Rondelli, Alessandra Todesco, Maurizio Bianchi, Alberto Garaventa, Marco Zecca, Paolo Indolfi, Valentino Conter, Nicola Santoro, Maurizio Aricò, Simone Cesaro, Salvatore D'amico, Piero Farruggia, Raffaela De Santis, Franco Locatelli, Stefano A Pileri, Giovanni Scarzello, Maurizio Mascarin, Vico Vecchi
Identify a subset of early-stage HL children (GR1) curable with limited chemotherapy+/-radiotherapy; improve outcome of intermediate (GR2) and high-risk (GR3) patients; establish impact of response to chemotherapy evaluated with conventional imaging (CI). One hundred and sixty GR1-patients received 3ABVD + involved-field (IF) low-dose (LD) (20 Gy) irradiation if mediastinal mass or partial response (PR) after chemotherapy. Eighty-five GR2- and 315 GR3-patients received 4 and 6 COPP/ABV + IFRT, respectively...
February 16, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29448383/microscopic-processes-controlling-the-herschel-bulkley-exponent
#9
Jie Lin, Matthieu Wyart
The flow curve of various yield stress materials is singular as the strain rate vanishes and can be characterized by the so-called Herschel-Bulkley exponent n=1/β. A mean-field approximation due to Hebraud and Lequeux (HL) assumes mechanical noise to be Gaussian and leads to β=2 in rather good agreement with observations. Here we prove that the improved mean-field model where the mechanical noise has fat tails instead leads to β=1 with logarithmic correction. This result supports that HL is not a suitable explanation for the value of β, which is instead significantly affected by finite-dimensional effects...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447896/bony-cochlear-nerve-canal-stenosis-in-pediatric-unilateral-sensorineural-hearing-loss
#10
Chae-Hyun Lim, Ji Hyung Lim, Doyoun Kim, Ho Sung Choi, Dong-Hee Lee, Dong-Kee Kim
OBJECTIVES: This study was performed to evaluate the frequency of bony cochlear nerve canal (BCNC) stenosis and its clinical significance in pediatric patients with unilateral sensorineural hearing loss (SNHL) of unknown etiology. MATERIALS AND METHODS: We analyzed the medical records and temporal bone computed tomography (CT) results of patients less than 13 years of age with a diagnosis of unilateral SNHL of unknown etiology between July 2007 and July 2017. We compared the BCNC diameter between both sides and analyzed the age at diagnosis, degree of hearing loss, and accompanying inner ear anomalies...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447274/health-literacy-of-hospital-patients-using-a-linguistically-validated-croatian-version-of-the-newest-vital-sign-screening-test-nvs-hr
#11
Sanja Brangan, Martina Ivanišić, Goranka Rafaj, Gill Rowlands
The Newest Vital Sign (NVS) is a simple, quick and accurate screening test for health literacy (HL). It has been validated for different languages but, to date, not for the Croatian language. The aim of this study was to develop a linguistically validated Croatian version of the NVS and to use it at a later stage in a pilot study of health literacy assessment of hospital patients in Croatia. A full linguistic validation procedure was applied, including forward and backward translation, expert panel review, cognitive interview with 10 respondents from general population, and full involvement in the procedure of one of the screening test developers, the lead author of the NVS-UK version...
2018: PloS One
https://www.readbyqxmd.com/read/29443738/hodgkin-lymphoma-involving-the-tonsil-misdiagnosed-as-tonsillar-carcinoma-a-case-report-and-review-of-the-literature
#12
You Qin, Lijuan Lu, Yanwei Lu, Kunyu Yang
RATIONALE: Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. Only about 20 such cases with verification of biopsy and immunohistochemistry have been reported. Because of its rarity and unremarkable clinical presentation, a timely correct diagnosis is very challenging. PATIENT CONCERNS: A 43-year-old man complained left tonsillar enlargement and painless masses in left neck, with night sweat. The clinical examination found a marked tonsillar asymmetry, with an enlarged left tonsil and ipsilateral cervical lymphadenopathy and a normal right tonsil...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442770/analysis-of-colchicine-induced-effects-on-hepatoma-and-hepatocyte-cells-by-atomic-force-microscopy
#13
Lanjiao Liu, Zuobin Wang, Wenxiao Zhang, Xinyao Zhu, Li Li, Zhankun Weng
Biomechanical properties of cells are altered by many diseases. Cancer cell metastasis is related to the properties such as the cell stiffness that influences cell proliferation, differentiation and migration. In this paper, we used an atomic force microscope to analyze the colchicine-induced effects on the mechanical properties of hepatocyte (HL-7702 cells) and hepatoma cells (SMCC-7721 cells) in culture at the nanoscale. The cells were exposed to a solution with a normal dose of colchicine for two, four and six hours...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442453/transcriptomic-analysis-of-the-pi3k-akt-signaling-pathway-reveals-the-dual-role-of-the-c-jun-oncogene-in-cytotoxicity-and-the-development-of-resistance-in-hl-60-leukemia-cells-in-response-to-arsenic-trioxide
#14
Joanna Roszak, Anna Smok-Pieniążek, Maciej Stępnik
BACKGROUND: Arsenic trioxide (ATO) is a well-recognized antileukemic drug used for the treatment of newly diagnosed and relapsed acute promyelocytic leukemia (APL). A major drawback of therapy with ATO is the development of APL cell resistance, the mechanisms of which are still not clear. OBJECTIVES: The aim of this study was to investigate the role of the PI3K/Akt signaling pathway in ATOtreated human acute myeloid leukemia (HL-60) cells and in ATO-resistant clones...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442212/spatial-clustering-of-childhood-cancers-in-switzerland-a-nationwide-study
#15
Garyfallos Konstantinoudis, Christian Kreis, Roland A Ammann, Felix Niggli, Claudia E Kuehni, Ben D Spycher
PURPOSE: Childhood cancers are rare and little is known about their etiology. Potential risk factors include environmental exposures that might implicate spatial variation of cancer risk. Previous studies of spatial clustering have mainly focused on childhood leukemia. We investigated spatial clustering of different childhood cancers in Switzerland using exact geocodes of place of residence. METHODS: We included 6,034 cancer cases diagnosed at age 0-15 years during 1985-2015 from the Swiss Childhood Cancer Registry...
February 13, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29442162/prognostic-meaning-of-neutrophil-to-lymphocyte-ratio-nlr-and-lymphocyte-to-monocyte-ration-lmr-in-newly-diagnosed-hodgkin-lymphoma-patients-treated-upfront-with-a-pet-2-based-strategy
#16
Alessandra Romano, Nunziatina Laura Parrinello, Calogero Vetro, Annalisa Chiarenza, Claudio Cerchione, Massimo Ippolito, Giuseppe Alberto Palumbo, Francesco Di Raimondo
Recent reports identify NLR (the ratio between absolute neutrophils counts, ANC, and absolute lymphocyte count, ALC), as predictor of progression-free survival (PFS) and overall survival (OS) in cancer patients. We retrospectively tested NLR and LMR (the ratio between absolute lymphocyte and monocyte counts) in newly diagnosed Hodgkin lymphoma (HL) patients treated upfront with a PET-2 risk-adapted strategy. NLR and LMR were calculated using records obtained from the complete blood count (CBC) from 180 newly diagnosed HL patients...
February 14, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29441835/current-profile-of-adults-presenting-for-preoperative-cochlear-implant-evaluation
#17
Jourdan T Holder, Susan M Reynolds, Linsey W Sunderhaus, René H Gifford
Considerable advancements in cochlear implant technology (e.g., electric acoustic stimulation) and assessment materials have yielded expanded criteria. Despite this, it is unclear whether individuals with better audiometric thresholds and speech understanding are being referred for cochlear implant workup and pursuing cochlear implantation. The purpose of this study was to characterize the mean auditory and demographic profile of adults presenting for preoperative cochlear implant workup. Data were collected prospectively for all adult preoperative workups at Vanderbilt from 2013 to 2015...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29439276/mannose-binding-lectin2-gene-polymorphism-and-igg4-in-membranous-nephropathy
#18
Denise Maria do Nascimento Costa, Lucila Maria Valente, Gisele Vajgel Fernandes, Paula Sandrin-Garcia, Heidi Lacerda Alves da Cruz, Sergio Crovella, Antônio Henrique Santana Cavalcante, Maria Alina Gomes de Mattos Cavalcante, Camila Barbosa Lyra de Oliveira, Carolina de Andrade Jordão de Vasconcelos, Emanuel Sávio Cavalcante Sarinho
BACKGROUND: Idiopathic membranous nephropathy (IMN) has been linked to the lectin pathway, IgG4 and genetic susceptibility. We investigated the frequency of mannose-binding lectin2 (MBL2) gene polymorphisms and the serum ratio of IgG4 in patients with membranous nephropathy (MN). METHODS: Polymorphisms in the exon 1 of the MBL2 gene (codons 52, 54, and 57) and single base polymorphisms at positions -550 (HL) and -221 (XY) in the promoter region were evaluated in 60 patients compared to a control group (CG) of 101 blood donors...
February 13, 2018: Nephron
https://www.readbyqxmd.com/read/29435404/magnetic-nature-of-the-criii-lniii-interactions-in-criii2lniii3-clusters-with-slow-magnetic-relaxation
#19
Xiao-Qing Zhao, Shuo Xiang, Jin Wang, Dong-Xu Bao, Yun-Chun Li
Two 3d-4f hetero-metal pentanuclear complexes with the formula {[CrIII2LnIII3L10(OH)6(H2O)2]Et3NH} [Ln=Tb (1), Dy (2); HL=pivalic acid, Et3N=triethylamine] have been produced. The metal core of each cluster is made up of a trigonal bipyramid with three LnIII ions (plane) and two CrIII ions (above and below) held together by six μ3-OH bridges. Also reported with this series is the diamagnetic CrIII-YIII analogue (3). Fortunately, we successfully prepared AlIII-LnIII analogues with the formula {[AlIII2LnIII3L10(OH)6(H2O)2]Et3NH⋅H2O} [Ln=Tb (4), Dy (5)], containing diamagnetic AlIII ions, which can be used to evaluate the CrIII-LnIII magnetic nature through a diamagnetic substitution method...
February 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29435156/cis-trimethoxy-resveratrol-induces-intrinsic-apoptosis-via-prometaphase-arrest-and-prolonged-cdk1-activation-pathway-in-human-jurkat-t-cells
#20
Chae Eun Kim, Do Youn Jun, Jong-Sik Kim, Young Ho Kim
Cis-trimethoxy resveratrol (cis-3M-RES) induced dose-dependent cytotoxicity and apoptotic DNA fragmentation in Jurkat T cell clones (JT/Neo); however, it induced only cytostasis in BCL-2-overexpressing cells (JT/BCL-2). Treatment with 0.25 μM cis-3M-RES induced G2/M arrest, BAK activation, Δψm loss, caspase-9 and caspase-3 activation, and poly (ADP-ribose) polymerase (PARP) cleavage in JT/Neo cells time-dependently but did not induce these events, except G2/M arrest, in JT/BCL-2 cells. Moreover, cis-3M-RES induced CDK1 activation, BCL-2 phosphorylation at Ser-70, MCL-1 phosphorylation at Ser-159/Thr-163, and BIM (BIMEL and BIML) phosphorylation irrespective of BCL-2 overexpression...
January 12, 2018: Oncotarget
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