keyword
MENU ▼
Read by QxMD icon Read
search

HL

keyword
https://www.readbyqxmd.com/read/29031074/synthesis-antiproliferative-anti-tubulin-activity-and-docking-study-of-new-1-2-4-triazoles-as-potential-combretastatin-analogues
#1
Muhamad Mustafa, Dalia Abdelhamid, ElShimaa M N Abdelhafez, Mahmoud A A Ibrahim, Amira M Gamal-Eldeen, Omar M Aly
Combretastatin A4 (CA4) is a natural product characterized by a powerful inhibition of tubulin polymerization and a potential anticancer activity. However, therapeutic application of CA4 is substantially hindered due to geometric isomerization. In the current study, new cis-restricted Combretastatin A4 analogues containing 1,2,4-triazle in place of the olefinic bond were designed and synthesized. The synthesized compounds were evaluated for their in vitro antiproliferative activity in human hepatocellular carcinoma HepG2 and leukemia HL-60 cell lines using MTT assay...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29028392/application-of-selected-reaction-monitoring-and-parallel-reaction-monitoring-for-investigation-of-hl-60-cell-line-differentiation
#2
Svetlana E Novikova, Olga V Tikhonova, Leonid K Kurbatov, Tatiana E Farafonova, Igor V Vakhrushev, Victor G Zgoda
Targeted mass spectrometry represents a powerful tool for investigation of biological processes. The convenient approach of selected reaction monitoring using stable isotope-labeled peptide standard (SIS) is widely applied for protein quantification. Along with this method, high-resolution parallel reaction monitoring has been increasingly used for protein targeted analysis. Here we applied two targeted approaches (selected reaction monitoring with SIS and label-free parallel reaction monitoring) to investigate expression of 11 proteins during all-trans retinoic acid-induced differentiation of HL-60 cells...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29027959/radiation-induced-changes-of-microrna-expression-profiles-in-radiosensitive-and-radioresistant-leukemia-cell-lines-with-different-levels-of-chromosome-abnormalities
#3
Daria Liamina, Wladimir Sibirnyj, Anna Khokhlova, Viacheslav Saenko, Eugenia Rastorgueva, Aleksandr Fomin, Yury Saenko
In our study, we estimate an effect from chromosome aberrations and genome mutations on changes in microRNA expression profiles in cancer cell lines demonstrating different radiosensitivity. Here, cell viability and microRNA spectrum have been estimated 1, 4, and 24 h after irradiation. MiSeq high-throughput sequencing system (Illumina, San Diego, CA, USA) is employed to perform microRNA spectrum estimation. In the K562 cell line, the number of expressed microRNAs in chromosomes demonstrates a more pronounced variation...
October 13, 2017: Cancers
https://www.readbyqxmd.com/read/29026537/negative-effects-of-long-term-feeding-of-high-grain-diets-to-lactating-goats-on-milk-fat-production-and-composition-by-regulating-gene-expression-and-dna-methylation-in-the-mammary-gland
#4
Ping Tian, Yanwen Luo, Xian Li, Jing Tian, Shiyu Tao, Canfeng Hua, Yali Geng, Yingdong Ni, Ruqian Zhao
BACKGROUND: It is well known that feeding a high concentrate (HC) diet to lactating ruminants likely induces subacute ruminal acidosis (SARA) and leads to a decrease in milk fat production. However, the effects of feeding a HC diet for long periods on milk fatty acids composition and the mechanism behind the decline of milk fat still remains poorly understood. The aim of this study was to investigate the impact of feeding a HC diet to lactating dairy goats on milk fat yield and fatty acids composition with an emphasis on the mechanisms underlying the milk fat depression...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29026263/effects-of-recreational-noise-on-threshold-and-suprathreshold-measures-of-auditory-function
#5
REVIEW
Angela N C Fulbright, Colleen G Le Prell, Scott K Griffiths, Edward Lobarinas
Noise exposure that causes a temporary threshold shift but no permanent threshold shift can cause degeneration of synaptic ribbons and afferent nerve fibers, with a corresponding reduction in wave I amplitude of the auditory brainstem response (ABR) in animals. This form of underlying damage, hypothesized to also occur in humans, has been termed synaptopathy , and it has been hypothesized that there will be a hidden hearing loss consisting of functional deficits at suprathreshold stimulus levels. This study assessed whether recreational noise exposure history was associated with smaller ABR wave I amplitude and poorer performance on suprathreshold auditory test measures...
November 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/29026057/pathological-outcome-for-chinese-patients-with-low-risk-prostate-cancer-eligible-for-active-surveillance-and-undergoing-radical-prostatectomy-comparison-of-six-different-active-surveillance-protocols
#6
C F Tsang, J Hl Tsu, T Ct Lai, K W Wong, B Sh Ho, A Tl Ng, W K Ma, M K Yiu
INTRODUCTION: Active surveillance is one of the therapeutic options for the management of patients with low-risk prostate cancer. This study compared the performance of six different active surveillance protocols for prostate cancer in the Chinese population. METHODS: Patients who underwent radical prostatectomy for prostate cancer from January 1998 to December 2012 at a university teaching hospital in Hong Kong were reviewed. Six active surveillance protocols were applied to the cohort...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025293/berberine-induces-apoptotic-cell-death-via-activation-of-caspase-3-and-8-in-hl-60-human-leukemia-cells-nuclear-localization-and-structure-activity-relationships
#7
Shinya Okubo, Takuhiro Uto, Aya Goto, Hiroyuki Tanaka, Tsuyoshi Nishioku, Katsushi Yamada, Yukihiro Shoyama
Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproliferative activity and promptly localized to the nucleus from 5[Formula: see text]min to 15[Formula: see text]min after BBR treatment in HL-60 human promyelocytic leukemia cells...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29024210/a-case-of-anaplastic-lymphoma-kinase-positive-renal-cell-carcinoma-coincident-with-hodgkin-lymphoma
#8
Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Tsutomu Daa, Dai Watanabe, Yasuyuki Akita, Fuminori Sato, Hiromitsu Mimata, Shigeo Yokoyama
We report a case of ALK-positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was a 19 year-old-girl without sickle cell trait. The right renal tumor was discovered concomitantly with Hodgkin lymphoma (HL). After chemotherapy for HL, right nephrectomy was performed. Microscopically, the tumor showed a solid and focally pseudo-papillary growth pattern studded with tubular structures. Most tumor cells were small bland eosinophilic cells, but rhabdoid cells, vacuolated cells, pleomorphic multinucleated giant cells were also admixed...
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29023692/lower-socioeconomic-status-is-independently-associated-with-shorter-survival-in-hodgkin-lymphoma-patients-an-analysis-from-the-brazilian-hodgkin-lymphoma-registry
#9
Irene Biasoli, Nelson Castro, Marcia Delamain, Talita Silveira, James Farley, Belinda Pinto Simões, Cristiana Solza, Monica Praxedes, Otávio Baiocchi, Rafael Gaiolla, Fernanda Franceschi, Caroline Bonamin Sola, Carla Boquimpani, Nelma Clementino, Guilherme Fleury Perini, Kátia Pagnano, Giovana Steffenello, Jacques Tabacof, Gilberto de Freitas Colli, Andrea Soares, Carmino de Souza, Carlos Sérgio Chiattone, Ronir Raggio Luiz, Cristiane Milito, José Carlos Morais, Nelson Spector
Socioeconomic status (SES) is a well-known determinant of outcomes in cancer. The purpose of this study was to analyze the impact of the SES on the outcomes of Hodgkin lymphoma (HL) patients from the Brazilian Prospective HL Registry. SES stratification was done using an individual asset/education-based household index. A total of 624 classical HL patients with diagnosis from January/2009 to December/2014, and treated with ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine), were analyzed. The median follow-up was 35...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29019717/adding-vfa-to-dxa-identifies-fracture-risk-in-a-way-not-duplicated-by-other-measures
#10
Jay P Ginther, Ann W Ginther, Lisa D Brodersen
OBJECTIVE: Published studies have demonstrated that adding Vertebral Fracture Assessment (VFA) to Dual-energy X-ray Absorptiometry (DXA) identifies more patients with increased fracture risk than DXA alone. But who needs VFA? This study attempts to determine if some test, other than VFA, could duplicate the additional information obtained by performing VFA on ALL first-time patients. This study looked at FRAX, Height Loss, Age, documented back pain, and Non-vertebral Fragility Fractures (FFs)...
October 11, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29018498/cortical-auditory-evoked-potentials-with-simple-tone-burst-and-complex-speech-stimuli-in-children-with-cochlear-implant
#11
Kelly Vasconcelos Chaves Martins, Daniela Gil
Introduction  The registry of the component P1 of the cortical auditory evoked potential has been widely used to analyze the behavior of auditory pathways in response to cochlear implant stimulation. Objective  To determine the influence of aural rehabilitation in the parameters of latency and amplitude of the P1 cortical auditory evoked potential component elicited by simple auditory stimuli (tone burst) and complex stimuli (speech) in children with cochlear implants. Method  The study included six individuals of both genders aged 5 to 10 years old who have been cochlear implant users for at least 12 months, and who attended auditory rehabilitation with an aural rehabilitation therapy approach...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29018493/variation-in-the-hearing-threshold-in-women-during-the-menstrual-cycle
#12
Dayse da Silva Souza, Brunna Luckwu, Wagner Teobaldo Lopes de Andrade, Luciane Spinelli de Figueiredo Pessoa, João Agnaldo do Nascimento, Marine Raquel Diniz da Rosa
Introduction  The hormonal changes that occur during the menstrual cycle and their relationship with hearing problems have been studied. However, they have not been well explained. Objective  The objective of our study is to investigate the variation in hearing thresholds in women during the menstrual cycle. Method  We conducted a cohort and longitudinal study. It was composed of 30 volunteers, aged 18-39 years old, of which 20 were women during the phases of the menstrual cycle and 10 were men (control group) who underwent audiometry and impedance exams, to correlate the possible audiological changes in each phase of the menstrual cycle...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29017675/familial-hodgkin-lymphoma
#13
Mahwish Faizan, Rahat Ul Ain Kashif, Saadia Anwar, Mansoor Safdar
Hodgkin Lymphoma (HL) is a lymphoid tumour that represents about 1% of all neoplasms occurring worldwide. HLis the most treatable of childhood malignancies. The etiology of HLis unknown. However, increase risk has been reported in males, with autoimmune diseases, poor socioeconomic status, increased family size, Ebstein Barr Virus (EBV) exposure, congenital or acquired immunodeficiency and those with a family history of HL. Familial HLis rare. The risk of developing HLis increased six times in the siblings of the affected patients...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28994864/tunisian-adult-s-hodgkin-lymphoma-study-group
#14
Raihane Ben Lakhal, Sondos Hdiji, Yosra Ben Youssef, Mohamed Adnène Laariri, Sami Zriba, Nabil Toumi, Amina Mokrani, Faten Ezzaier, Salwa Ladb, Hatem Frikha, Taha Mesai, Hanen Ben Salah, Sameh Tebra, Jamel Daoued, Noureddine Bouaouina, Monji Maalej, Mounir Frikha, Slim Ben Ahmed, Amel Mezlini, Tarek Ben Othmen, Fehmi Msaddek, Abderrahim Khelif, Moez Elloumi, Balkis Meddeb
The Tunisian adult's Hodgkin lymphoma (HL) Study Group was created in 1999. It aimed to improve the management of this curable hematologic malignancy by standardizing the diagnosis, assessment of disease, treatment management and therapeutic evaluation in different Tunisian centers (Hematology, oncology and radiotherapy).Since 1998, four versions of the prospective national protocol for treating adult Hodgkin lymphoma have succeeded (MDH99, MDH2002, MDH2008, MDH2015). Each version was based on the results of the previous version and analyzed according to new data from the literature...
November 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28993980/characterization-cytotoxicity-and-genotoxicity-of-tio2-and-folate-coupled-chitosan-nanoparticles-loading-polyprenol-based-nanoemulsion
#15
Ran Tao, Chengzhang Wang, Changwei Zhang, WenJun Li, Hao Zhou, Hongxia Chen, Jianzhong Ye
The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving polyprenol in nanoemulsion of sodium tripolyphosphate (TPP)/TiO2 solution, Triton X-100, and 1-octanol by inversed-phase emulsification (EIP) and ultrasonic emulsification (UE) method. Folic acid (FA)-coupled chitosan (CS) nanoparticles (NPs), GBP-FA-CS-NPs and GBP-TiO2-FA-CS-NPs, were fabricated by ionic cross-linking of positively charged FA-CS conjugates and negatively charged nanoemulsion with TPP/TiO2...
October 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28992524/early-reduction-of-serum-tarc-levels-may-predict-for-success-of-abvd-as-frontline-treatment-in-patients-with-hodgkin-lymphoma
#16
A Guidetti, A Mazzocchi, R Miceli, E Paterno', F Taverna, F Spina, F Crippa, L Farina, P Corradini, A M Gianni, S Viviani
BACKGROUND: Many efforts have been made to predict prognosis of newly diagnosed Hodgkin Lymphoma (HL) patients. Objective of this study was to investigate the association between early reduction of Thymus and Activation-Regulated Chemokine after the first ABVD cycle (TARC-1) and prognosis of HL patients. METHODS: Serum samples of 116 HL patients were collected at baseline, after every ABVD cycle and during follow-up. The 99th centile of TARC distribution in a group of 156 independent healthy subjects (800pg/ml) was considered as cut-off for discriminating between abnormal and normal TARC values...
September 25, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28990778/benzo-a-pyrene-induces-autophagic-and-pyroptotic-death-simultaneously-in-hl-7702-human-normal-liver-cells
#17
Li Yuan, Junyi Liu, Hong Deng, Chunxia Gao
As a common polycyclic aromatic hydrocarbon compound, benzo(α)pyrene (BaP) is readily produced in processing of oil and fatty foods. It is not only a strong carcinogen, but also a substance with strong immunotoxicity and reproduction toxicity. Autophagy and pyroptosis are two types of programmed cell death. Whether or not BaP damages body tissues via autophagy or pyroptosis remains unknown. The present study investigated the effects of BaP on autophagy and pyroptosis in HL-7702 cells. The results showed that BaP induced cell death in HL-7702 cells, enhanced the intracellular levels of ROS, arrested cell cycle at the S phase...
October 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28988670/treatment-patterns-and-outcomes-in-early-stage-hodgkin-lymphoma-in-the-elderly-a-national-cancer-database-analysis
#18
Gaurav Goyal, Edward B Maldonado, Tiffany J Fan, Arun Kanmanthareddy, Peter T Silberstein, Ronald S Go, James O Armitage
BACKGROUND: The outcome for early-stage (I/II) Hodgkin lymphoma (HL) has improved significantly during the past few decades. However, older age (≥ 60 years) has continued to be associated with poor outcomes, and a paucity of data is available defining the optimal treatment regimens. In the present study, we sought to identify the practice patterns and outcomes in elderly patients with early-stage HL using the National Cancer Database. MATERIALS AND METHODS: We performed a retrospective study of patients aged 60 years with early-stage classic HL diagnosed from 2004 to 2012...
September 20, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28988553/color-temperature-of-light-emitting-diode-lighting-matters-for-optimum-growth-and-welfare-of-broiler-chickens
#19
G S Archer
Light-emitting diode (LED) light bulbs are becoming more prevalent in broiler production as they are dimmable and more energy efficient than compact fluorescent lamps. Although there is some research on how spectrum of light can affect production, little has been conducted on how it may affect stress, and behavior. To determine how different spectrum of light produced by LED lights could affect production, stress and behavior we raised broilers under either 2700 K (WARM) or 5000 K (COOL) color temperature LED bulbs...
October 9, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28988325/advances-in-understanding-the-molecular-mechanisms-of-cytoplasmic-male-sterility-and-restoration-in-rice
#20
Huiwu Tang, Yongyao Xie, Yao-Guang Liu, Letian Chen
Cytoplasmic male sterility (CMS) in plants is a male reproductive defect determined by mitochondrial genes and inherited maternally. CMS can be suppressed by nuclear restorer of fertility (Rf) genes. Therefore, CMS/Rf systems provide a classic model for the study of mitochondrial-nuclear interactions in plants. Moreover, CMS/Rf systems are economical, effective tools for the production of hybrid seeds. For example, CMS/Rf systems have been applied in over forty countries to breed hybrid rice (Oryza sativa L...
October 7, 2017: Plant Reproduction
keyword
keyword
38537
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"