keyword
MENU ▼
Read by QxMD icon Read
search

HL

keyword
https://www.readbyqxmd.com/read/29241162/in-vitro-and-in-vivo-activity-of-fomitopsis-pinicola-sw-ex-fr-karst-chloroform-fpkc-extract-against-s180-tumor-cells
#1
Ye Gao, Pan Wang, Yaqin Wang, Lijie Wu, Xiaobing Wang, Kun Zhang, Quanhong Liu
BACKGROUND/AIMS: Non-toxic fomitopsis is has been traditionally used in folk medicine in many countries for its anti-inflammatory and anti-vascular disease activities. The present study investigates the antitumor effect of Fomitopsis pinicola (Sw. Ex Fr.) Karst chloroform extract (FPKc) on S180 tumor cells in vitro and in vivo and we determined the underlying mechanisms. METHODS: HPLC was employed to analyze the constituents of FPKc. In-vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to quantify the growth inhibition of FPKc; Propidium iodide (PI) exclusion assay and scanning electron microscopy (SEM) were used to observe the damage on the cell membrane and the changes of the cell morphology; Staining with Hoechst 33342/propidium iodide (HO/PI) and the application of the Annexin V-FITC/PI analysis permitted to observe the cell death triggered by FPKc; DNA damage and cell cycle arrest were detected by flow cytometry; Rhodamine 123 (RH123) and Cytochrome C were used as dyes to investigate the alterations of the mitochondria...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29240303/discovery-of-novel-negletein-derivatives-as-potent-anticancer-agents-for-acute-myeloid-leukemia
#2
Jianlei Wu, Yingyu Chen, Xuanping Liu, Yu Gao, Jianda Hu, Haijun Chen
Baicalin and its aglycone baicalein derived from Scutellaria baicalensis exhibited potent anticancer effects in various types of cancer cell lines. However, the unfavorable pharmaceutical properties became the main obstacle for their potential clinical development. With the aim of development of novel anticancer agents based on the skeleton of baicalin, a series of novel negletein derivatives were designed and synthesized. Among them, compound 8 (FZU-02,006) with an N,N-dimethylamino ethoxyl moitey at the C6 position exhibited significant enhanced antiproliferative effect against HL-60 cells in vitro through regulating multi-signaling pathways...
December 14, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29239464/cd20-role-in-pathophysiology-of-hodgkin-s-disease
#3
Marcelo Antônio Oliveira Santos, Marinus de Moraes Lima
Hodgkin's lymphoma (HL) is a tumor comprising non-malignant and malignant B-cells. Classical HL expresses CD15+ and CD30+ antigens, and 20 to 40% of patients are CD20+. This antigen is a ligand free protein present in B lymphocyte cells and its function is not well known. Some studies suggest that expression of CD20 may play a major role in Hodgkin's disease pathophysiology and may affect the patients' treatment prognosis, as well as relapse and refractory response. In the past few years, development of monoclonal anti-CD20 antibodies changed drastically the treatment for non-Hodgkin lymphomas in which CD20 is expressed...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238738/sociodemographic-characteristics-health-literacy-and-care-compliance-in-families-with-spina-bifida
#4
Jennifer Cooper, Deena Chisolm, Daryl J McLeod
Children with spina bifida experience varying rates of disease complications and health system overutilization. Data on sociodemographics, urinary tract infection, clean intermittent catheterization, and health system utilization were collected from caregiver-patient dyads. Newest Vital Sign (NVS) and Brief Health Literacy Screen (BRIEF) were administered to evaluate health literacy (HL). In total, 105 dyads completed enrolment with 24.8% versus 12.4% of caregivers scoring poor/marginal on the NVS and BRIEF, respectively...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29237899/role-of-surgical-treatment-for-hepatolithiasis-associated-intrahepatic-cholangiocarcinoma-a-retrospective-study-in-a-single-institution
#5
Jian Xiao, Jisheng Zhu, Zhanying Liu, Renhua Wan, Yong Li, Weidong Xiao
CONTEXT: The extent of hepatectomy and lymph node dissection (LND) in the treatment of hepatolithiasis-associated intrahepatic cholangiocarcinoma (HL-iCCA) is still controversial. AIMS: The aim of this retrospective study was to evaluate the role of surgical treatment for HL-iCCA. METHODS: The clinical data of 63 patients with HL-iCCA who undergoing surgery between January 2005 and December 2015 were analyzed retrospectively. STATISTICAL ANALYSIS USED: All data were analyzed by the SPSS 17...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29236751/lysophosphatidic-acid-receptor-mrna-levels-in-heart-and-white-adipose-tissue-are-associated-with-obesity-in-mice-and-humans
#6
Amy Brown, Intekhab Hossain, Lester J Perez, Carine Nzirorera, Kathleen Tozer, Kenneth D'Souza, Purvi C Trivedi, Christie Aguiar, Alexandra M Yip, Jennifer Shea, Keith R Brunt, Jean-Francois Legare, Ansar Hassan, Thomas Pulinilkunnil, Petra C Kienesberger
BACKGROUND: Lysophosphatidic acid (LPA) receptor signaling has been implicated in cardiovascular and obesity-related metabolic disease. However, the distribution and regulation of LPA receptors in the myocardium and adipose tissue remain unclear. OBJECTIVES: This study aimed to characterize the mRNA expression of LPA receptors (LPA1-6) in the murine and human myocardium and adipose tissue, and its regulation in response to obesity. METHODS: LPA receptor mRNA levels were determined by qPCR in i) heart ventricles, isolated cardiomyocytes, and perigonadal adipose tissue from chow or high fat-high sucrose (HFHS)-fed male C57BL/6 mice, ii) 3T3-L1 adipocytes and HL-1 cardiomyocytes under conditions mimicking gluco/lipotoxicity, and iii) human atrial and subcutaneous adipose tissue from non-obese, pre-obese, and obese cardiac surgery patients...
2017: PloS One
https://www.readbyqxmd.com/read/29236744/multilayer-perceptron-architecture-optimization-using-parallel-computing-techniques
#7
Wilson Castro, Jimy Oblitas, Roberto Santa-Cruz, Himer Avila-George
The objective of this research was to develop a methodology for optimizing multilayer-perceptron-type neural networks by evaluating the effects of three neural architecture parameters, namely, number of hidden layers (HL), neurons per hidden layer (NHL), and activation function type (AF), on the sum of squares error (SSE). The data for the study were obtained from quality parameters (physicochemical and microbiological) of milk samples. Architectures or combinations were organized in groups (G1, G2, and G3) generated upon interspersing one, two, and three layers...
2017: PloS One
https://www.readbyqxmd.com/read/29236095/health-literacy-and-hospital-length-of-stay-an-inpatient-cohort-study
#8
Ethan G Jaffee, Vineet M Arora, Madeleine I Matthiesen, David O Meltzer, Valerie G Press
BACKGROUND: Associations between low health literacy (HL) and adverse health outcomes have been well documented in the outpatient setting; however, few studies have examined associations between low HL and in-hospital outcomes. OBJECTIVE: To compare hospital length of stay (LOS) among patients with low HL and those with adequate HL. DESIGN: Hospital-based cohort study. SETTING: Academic urban tertiary-care hospital. PATIENTS: Hospitalized general medicine patients...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29234114/probing-the-requirement-for-cd38-in-retinoic-acid-induced-hl-60-cell-differentiation-with-a-small-molecule-dimerizer-and-genetic-knockout
#9
Robert J MacDonald, Jonathan H Shrimp, Hong Jiang, Lu Zhang, Hening Lin, Andrew Yen
CD38 is an ectoenzyme and receptor with key physiological roles. It metabolizes NAD+ to adenosine diphosphate ribose (ADPR) and cyclic ADPR, regulating several processes including calcium signalling. CD38 is both a positive and negative prognostic indicator in leukaemia. In all-trans retinoic acid (RA)-induced differentiation of acute promyelocytic leukaemia and HL-60 cells, CD38 is one of the earliest and most prominently upregulated proteins known. CD38 overexpression enhances differentiation, while morpholino- and siRNA-induced knockdown diminishes it...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233742/how-to-approach-a-hodgkin-lymphoma-patient-with-relapse-after-autologous-sct-allogeneic-sct
#10
REVIEW
Matthew Mei, Robert Chen
Hodgkin lymphoma (HL) is a highly curable B-cell lymphoma, and ∼90% of patients who present with early-stage (stage I-II) disease and 70% of patients who present with late-stage disease will be cured with standard frontline treatment. For patients with relapsed or refractory (r/r) disease after initial therapy, the standard of care is salvage chemotherapy, followed by autologous transplantation (autoSCT). Although this approach will cure a significant proportion of patients, upto 50% of patients will experience disease progression after autoSCT, and this population has historically had a very poor prognosis...
December 9, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29233497/early-and-late-survival-of-on-pump-cardiac-surgery-patients-formerly-affected-by-lymphoma
#11
Giuseppe Gatti, Oscar Maraldo, Bernardo Benussi, Rossana Bussani, Gianluca Castaldi, Gianfranco Sinagra, Aniello Pappalardo
BACKGROUND: Survival after cardiac surgery of patients formerly affected by lymphoma has not been well defined. METHODS: Forty-five consecutive patients having prior Hodgkin's (HL patients, n=26) or non-Hodgkin's lymphoma (non-HL patients, n=19) underwent on-pump cardiac surgery at the authors' institution (2001-2016). Ischaemic, valvular, and ischaemic plus valvular heart disease were present in 14, 13, and 18 patients, respectively. Concomitant aortic disease was treated in three cases...
November 28, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29233221/lysozyme-s-lectin-like-characteristics-facilitates-its-immune-defense-function
#12
Ruiyan Zhang, Lisha Wu, Thomas Eckert, Monika Burg-Roderfeld, Miguel A Rojas-Macias, Thomas Lütteke, Vadim B Krylov, Dmitry A Argunov, Aritreyee Datta, Philipp Markart, Andreas Guenther, Bengt Norden, Roland Schauer, Anirban Bhunia, Mushira Abdelaziz Enani, Martin Billeter, Axel J Scheidig, Nikolay E Nifantiev, Hans-Christian Siebert
Interactions between human lysozyme (HL) and the lipopolysaccharide (LPS) of Klebsiella pneumoniae O1, a causative agent of lung infection, were identified by surface plasmon resonance. To characterize the molecular mechanism of this interaction, HL binding to synthetic disaccharides and tetrasaccharides representing one and two repeating units, respectively, of the O-chain of this LPS were studied. pH-dependent structural rearrangements of HL after interaction with the disaccharide were observed through nuclear magnetic resonance...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/29232633/carbazole-alkaloids-from-clausena-hainanensis-with-their-potential-antiproliferative-activities
#13
Yan-Lei Ma, Yan-Ping Liu, Chao Zhang, Wan-Hui Zhao, Shi Shi, Dan-Nv He, Pan Zhang, Xiao-Hong Liu, Ting-Ting Han, Yan-Hui Fu
Five new carbazole alkaloids, clausehainanines A-E (1-5), together with seven known analogues (6-12) were isolated from the stems and leaves of C. hainanensis. Their structures were elucidated by extensive spectroscopic methods. Among them, compounds 1-5 were an unusual type of carbazole alkaloids, possessing diverse isopentenyl derivatives as substituents at C-2. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29232190/the-effects-of-curcuma-longa-and-curcumin-on-reproductive-systems
#14
R Mohebbati, A Anaeigoudari, M R Khazdair
OBJECTIVE: Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-inflammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an effort on a detailed literature survey concentrated on the protective effects of C...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29230892/stable-zn-i-containing-mofs-with-large-zn70-nanocages-from-assembly-of-zn-ii-ions-and-aromatic-zni8-clusters
#15
Bin Zhao, Huan-Cheng Hu, Ping Cui, Han-Shi Hu, Peng Cheng, Jun Li
Two unique Zn(I)-containing MOFs {[ZnI8ZnII3(H2O)x(HL)12](OH)2∙13H2O}n (x=6, 1; x=2, 2) (HL = tetrazole monoanion) with highnuclear Zn-cages were prepared successfully. These Zn-cages constructed from [ZnI8] clusters with multicentered Zn(I)-Zn(I) bonds and Zn(II) ions. [ZnI8] clusters in 1 and 2 display Oh and D4h symmetry, respectively. Importantly, eight [ZnI8] clusters and six Zn(II) ions form a large [Zn70] nanocage in 1. To our knowledge, this is the first MOFs based on polynuclear Zn-cage consisted of Zn(I) and Zn(II) ions...
December 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29229883/in-vitro-leishmanicidal-antibacterial-and-antitumour-potential-of-anhydrocochlioquinone-a-obtained-from-the-fungus-cochliobolus-sp
#16
Fernanda F Campos, Jonas P Ramos, Djalma M DE Oliveira, Tania M A Alves, Elaine M DE Souza-Fagundes, Carlos L Zani, Fabio C Sampaio, Attilio Converti, Betania B Cota
The bioassay-guided fractionation of the ethyl acetate extract of the fungus Cochliobolus sp. highlighted leishmanicidal activity and allowed for anhydrocochlioquinone A (ANDC-A) isolation. MS, 1D and 2D NMR spectra of this compound were in agreement with those published in the literature. ANDC-A exhibited leishmanicidal activity with EC 50 value of 22.4 microgram/mL (44 mu M) and, when submitted to the microdilution assay against Gram-ositive and Gram-negative bacteria, showed a minimal inhibitory concentration against Staphylococcus aureus ATCC 25295 of 128 microgram/mL (248...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29229594/interim-results-of-brentuximab-vedotin-in-combination-with-nivolumab-in-patients-with-relapsed-or-refractory-hodgkin-lymphoma
#17
Alex F Herrera, Alison J Moskowitz, Nancy L Bartlett, Julie M Vose, Radhakrishnan Ramchandren, Tatyana A Feldman, Ann S LaCasce, Stephen M Ansell, Craig H Moskowitz, Keenan Fenton, Carol Anne Ogden, David Taft, Qu Zhang, Kazunobu Kato, Mary Campbell, Ranjana H Advani
In this phase 1/2 study, brentuximab vedotin (BV) and nivolumab (Nivo) administered in combination were evaluated as initial salvage therapy in patients with relapsed or refractory (R/R) classical Hodgkin lymphoma (HL) (ClinicalTrials.gov #NCT02572167). Patients received up to 4 cycles of combination treatment, with BV administered on Day 1 and Nivo on Day 8 of the first cycle. For Cycles 2-4, BV and Nivo were both administered on Day 1. Following study treatment, responses were evaluated by investigators per the 2014 Lugano classification, and patients could proceed to autologous stem cell transplantation (ASCT)...
December 11, 2017: Blood
https://www.readbyqxmd.com/read/29229324/comparison-of-36%C3%A2-gy-20%C3%A2-gy-or-no-radiation-therapy-after-6-cycles-of-ebvp-chemotherapy-and-complete-remission-in-early-stage-hodgkin-lymphoma-without-risk-factors-results-of-the-eort-gela-h9-f-intergroup-randomized-trial
#18
José Thomas, Christophe Fermé, Evert M Noordijk, Franck Morschhauser, Théodore Girinsky, Isabelle Gaillard, Pieternella J Lugtenburg, Marc André, Marnix L M Lybeert, Aspasia Stamatoullas, Max Beijert, Philippe Hélias, Houchingue Eghbali, Jean Gabarre, Richard W M van der Maazen, Jérôme Jaubert, Krimo Bouabdallah, Olivier Boulat, Judith M Roesink, Bernard Christian, Francisca Ong, Dominique Bordessoule, Gérard Tertian, Hugo Gonzalez, Andrej Vranovsky, Philippe Quittet, Umberto Tirelli, Daphne de Jong, Josée Audouin, Berthe M P Aleman, Michel Henry-Amar
PURPOSE: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy. METHODS AND MATERIALS: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0...
October 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29228840/investigational-pd-1-inhibitors-in-hl-and-nhl-and-biomarkers-for-predictors-of-response-and-outcome
#19
Andres Chang, Danielle Schlafer, Christopher R Flowers, Pamela B Allen
Inhibitors against the PD-1/PD-L1 pathway are revolutionizing the treatment and management of malignancies. Areas covered: We summarize our current understanding of the function of PD-1, its role in immune evasion, the clinical data available that support the use of PD-1 antagonist in Hodgkin and non-Hodgkin lymphomas, and potential predictors of response. Expert opinion: We anticipate that in the next 10 years, agents that modulate the immune system such as PD-1 antagonists will be increasingly used in favor over traditional cytotoxic chemotherapeutic agents...
December 12, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29228452/establishment-and-analysis-of-the-prediction-model-for-cervical-squamous-cell-carcinoma
#20
Y-H Zhou, W-F Fan, J Deng, H-L Xi
OBJECTIVE: This study aimed to construct a prediction model for cervical squamous cell carcinoma and evaluate its accuracy in diagnosing cervical squamous cell carcinoma. PATIENTS AND METHODS: Fifty patients with initially histopathologically confirmed cervical squamous cell carcinoma and 150 patients with initially histopathologically confirmed cervical intraepithelial neoplasia (CIN) were enrolled. The high-risk human papillomavirus (HR-HPV) infection, human telomerase mRNA component (hTERC) gene and cell-myc (c-myc) gene amplification, and minichromosome maintenance protein 5 (MCM5) protein expression were detected...
November 2017: European Review for Medical and Pharmacological Sciences
keyword
keyword
38537
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"