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https://www.readbyqxmd.com/read/28220184/cxcl12a-cxcr4b-acts-to-retain-neutrophils-in-caudal-hematopoietic-tissue-and-to-antagonize-recruitment-to-an-injury-site-in-the-zebrafish-larva
#1
Susana Paredes-Zúñiga, Rodrigo A Morales, Salomé Muñoz-Sánchez, Carlos Muñoz-Montecinos, Margarita Parada, Karina Tapia, Carlos Rubilar, Miguel L Allende, Oscar A Peña
Neutrophils are a major component of the innate immune response and the most abundant circulating cell type in humans and zebrafish. The CXCL12/CXCR4 ligand receptor pair plays a key role in neutrophil homeostasis, controlling definitive hematopoiesis and neutrophil release into circulation. Neutrophils overexpressing CXCR4 respond by migrating towards sources of CXCL12, which is abundant in hematopoietic tissues. However, the physiological role of CXCL12/CXCR4 signaling during inflammatory responses remains unknown...
February 20, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28216769/the-insanity-defense-related-issues
#2
REVIEW
T V Asokan
For the past 150 years, there is no change in the understanding and knowledge other than autonomy and capacity to choose the right and wrong for criminal liability. The alternative concept that human behavior is the result of an interaction between biological and environmental factors other than free choice failed to impress the criminal justice system because of a direct threat to a society's deep seated need to blame someone than themselves for criminal harms that occur. The insanity defense has a long history, and is evolved after many tests that have been tried and tested...
December 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28215240/morningness-eveningness-correlates-with-sleep-time-quality-and-hygiene-in-secondary-school-students-a-multilevel-analysis
#3
Christian Vollmer, Konrad S Jankowski, Juan F Díaz-Morales, Heike Itzek-Greulich, Peter Wüst-Ackermann, Christoph Randler
At the onset of puberty, students shift their sleep to later hours, but school starts early. It is suggested that evening orientation and early school start times do not go well together. Therefore, the aim of this study was to investigate sleep problems in adolescence, and it was expected that the adolescents' eveningness orientation is associated with many sleep-related problems. Students of secondary education (n = 3201; mean = 13.8 ± 1.8 years) filled out a self-report questionnaire containing measures of morningness-eveningness, sleep time (midpoint of sleep, social "jetlag"), sleep length (on schooldays and on weekends), sleep quality, and sleep hygiene as well as questions on electronic screen media use...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28211503/the-enforcement-of-moral-boundaries-promotes-cooperation-and-prosocial-behavior-in-groups
#4
Brent Simpson, Robb Willer, Ashley Harrell
The threat of free-riding makes the marshalling of cooperation from group members a fundamental challenge of social life. Where classical social science theory saw the enforcement of moral boundaries as a critical way by which group members regulate one another's self-interest and build cooperation, moral judgments have most often been studied as processes internal to individuals. Here we investigate how the interpersonal expression of positive and negative moral judgments encourages cooperation in groups and prosocial behavior between group members...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210230/acute-mental-discomfort-associated-with-suicide-behavior-in-a-clinical-sample-of-patients-with-affective-disorders-ascertaining-critical-variables-using-artificial-intelligence-tools
#5
Susana Morales, Jorge Barros, Orietta Echávarri, Fabián García, Alex Osses, Claudia Moya, María Paz Maino, Ronit Fischman, Catalina Núñez, Tita Szmulewicz, Alemka Tomicic
AIM: In efforts to develop reliable methods to detect the likelihood of impending suicidal behaviors, we have proposed the following. OBJECTIVE: To gain a deeper understanding of the state of suicide risk by determining the combination of variables that distinguishes between groups with and without suicide risk. METHOD: A study involving 707 patients consulting for mental health issues in three health centers in Greater Santiago, Chile. Using 345 variables, an analysis was carried out with artificial intelligence tools, Cross Industry Standard Process for Data Mining processes, and decision tree techniques...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28206845/changes-in-affective-and-cognitive-empathy-among-veterinary-practitioners
#6
Regina M Schoenfeld-Tacher, Jane R Shaw, Beatrice Meyer-Parsons, Lori R Kogan
Clinical empathy is a multi-dimensional concept characterized by four dimensions: (1) affective-the ability to experience patients' or clients' emotions and perspectives, (2) moral-the internal motivation to empathize, (3) cognitive-the intellectual ability to identify and comprehend others' perspective and emotions, and (4) behavioral-the ability to convey understanding of those emotions and perspectives back to the patient or client. The Davis Interpersonal Reactivity Index (IRI) was used to examine the affective and cognitive facets of empathy in veterinary practitioners...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28191999/chronic-and-episodic-anger-and-gratitude-toward-the-organization-relationships-with-organizational-and-supervisor-supportiveness-and-extrarole-behavior
#7
Michael T Ford, Yanxia Wang, Jiafei Jin, Robert Eisenberger
Gratitude and anger represent 2 fundamental moral emotions in response to help or harm. Research suggests that individuals perceive organizations to have humanlike qualities and thus hold them responsible for helpful or harmful treatment. Given this line of reasoning, we hypothesized that workers direct gratitude toward their organizations in response to supportive treatment and anger toward their organizations in response to unsupportive treatment. Gratitude and anger, in turn, were expected to influence daily extrarole behavior...
February 13, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28191027/is-moral-elevation-an-approach-oriented-emotion
#8
Julie Van de Vyver, Dominic Abrams
Two studies were designed to test whether moral elevation should be conceptualized as an approach-oriented emotion. The studies examined the relationship between moral elevation and the behavioral activation and inhibition systems. Study 1 (N = 80) showed that individual differences in moral elevation were associated with individual differences in behavioral activation but not inhibition. Study 2 (N = 78) showed that an elevation-inducing video promoted equally high levels of approach orientation as an anger-inducing video and significantly higher levels of approach orientation than a control video...
March 4, 2017: Journal of Positive Psychology
https://www.readbyqxmd.com/read/28190696/ethical-issues-in-research
#9
REVIEW
Raul Artal, Sheldon Rubenfeld
Biomedical research is currently guided by ethical standards that have evolved over many centuries. Historical and political events, social and legal considerations, and continuous medical and technological advances have led to the prevailing research ethics and practice. Currently, patients and research subjects have complete autonomy while under medical care or when volunteering as research subjects. Enrolling volunteers in human subjects research includes a detailed and meaningful informed consent process that follows the cardinal principles of ethics: autonomy, beneficence, nonmaleficence, and justice...
January 23, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28188691/zebrafish-transgenic-constructs-label-specific-neurons-in-xenopus-laevis-spinal-cord-and-identify-frog-v0v-spinal-neurons
#10
José L Juárez-Morales, Reyna I Martinez-De Luna, Michael E Zuber, Alan Roberts, Katharine E Lewis
A correctly functioning spinal cord is crucial for locomotion and communication between body and brain but there are fundamental gaps in our knowledge of how spinal neuronal circuitry is established and functions. To understand the genetic program that regulates specification and functions of this circuitry, we need to connect neuronal molecular phenotypes with physiological analyses. Studies using Xenopus laevis tadpoles have increased our understanding of spinal cord neuronal physiology and function, particularly in locomotor circuitry...
February 11, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28185749/workplace-bullying-in-radiology-and-radiation-oncology
#11
Jay R Parikh, Jay A Harolds, Edward I Bluth
Workplace bullying is common in health care and has recently been reported in both radiology and radiation oncology. The purpose of this article is to increase awareness of bullying and its potential consequences in radiology and radiation oncology. Bullying behavior may involve abuse, humiliation, intimidation, or insults; is usually repetitive; and causes distress in victims. Workplace bullying is more common in health care than in other industries. Surveys of radiation therapists in the United States, student radiographers in England, and physicians-in-training showed that substantial proportions of respondents had been subjected to workplace bullying...
February 6, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28166248/characterization-of-three-dimensional-cancer-cell-migration-in-mixed-collagen-matrigel-scaffolds-using-microfluidics-and-image-analysis
#12
María Anguiano, Carlos Castilla, Martin Maška, Cristina Ederra, Rafael Peláez, Xabier Morales, Gorka Muñoz-Arrieta, Maite Mujika, Michal Kozubek, Arrate Muñoz-Barrutia, Ana Rouzaut, Sergio Arana, José Manuel Garcia-Aznar, Carlos Ortiz-de-Solorzano
Microfluidic devices are becoming mainstream tools to recapitulate in vitro the behavior of cells and tissues. In this study, we use microfluidic devices filled with hydrogels of mixed collagen-Matrigel composition to study the migration of lung cancer cells under different cancer invasion microenvironments. We present the design of the microfluidic device, characterize the hydrogels morphologically and mechanically and use quantitative image analysis to measure the migration of H1299 lung adenocarcinoma cancer cells in different experimental conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28165276/climate-change-helplessness-and-the-de-moralization-of-individual-energy-behavior
#13
Erika Salomon, Jesse L Preston, Melanie B Tannenbaum
Although most people understand the threat of climate change, they do little to modify their own energy conservation behavior. One reason for this gap between belief and behavior may be that individual actions seem unimpactful and therefore are not morally relevant. This research investigates how climate change helplessness-belief that one's actions cannot affect climate change-can undermine the moralization of climate change and personal energy conservation. In Study 1, climate change efficacy predicted both moralization of energy use and energy conservation intentions beyond individual belief in climate change...
February 6, 2017: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/28164463/impact-of-the-feedback-provided-by-a-gastric-electrical-stimulation-system-on-eating-behavior-and-physical-activity-levels
#14
Luca Busetto, Antonio J Torres, Salvador Morales-Conde, Isaias Alarcón Del Agua, Carlo Moretto, Paola Fierabracci, Giuseppe Rovera, Gianni Segato, Miguel A Rubio, Franco Favretti
OBJECTIVE: The closed-loop gastric electrical stimulation (CLGES) abiliti(®) system provides tailored gastric electrical stimulation activated by food entry into the stomach and sensor-based data to medical professionals. The aim of this study was to analyze behavior changes using sensor-based food intake and activity data in participants treated with the CLGES system. METHODS: Food intake and activity data (3D accelerometer) were downloaded at baseline and monthly/bimonthly for 12 months in a subset of patients with obesity (N = 45) participating in a multicenter trial with CLGES...
February 6, 2017: Obesity
https://www.readbyqxmd.com/read/28161388/estrogen-dependent-estrous-behavior-in-rabbits-is-antagonized-by-the-antiprogestin-ru486
#15
Gabriela González-Mariscal, José Antonio Gallegos, Rafael I Rueda Morales, Kurt Hoffman
Estrogen receptor-alpha (ERα) dimerizes with unliganded progesterone receptor (PR) in target tissues to trigger genomic and non-genomic effects. In ovariectomized rats the antiprogestin RU486 or antisense nucleotides against PR antagonize estradiol-induced sexual receptivity. We determined the relevance of unliganded PR for the expression of estrogen-dependent scent-marking (chinning) and sexual receptivity by injecting RU486 to: a) ovariectomized (ovx) rabbits given estradiol benzoate (EB; 5μg/day); b) intact rabbits...
February 1, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28155201/dad-s-snoring-may-have-left-molecular-scars-in-your-dna-the-emerging-role-of-epigenetics-in-sleep-disorders
#16
REVIEW
Daniela Morales-Lara, Clelia De-la-Peña, Eric Murillo-Rodríguez
The sleep-wake cycle is a biological phenomena under the orchestration of neurophysiological, neurochemical, neuroanatomical, and genetical mechanisms. Moreover, homeostatic and circadian processes participate in the regulation of sleep across the light-dark period. Further complexity of the understanding of the genesis of sleep engages disturbances which have been characterized and classified in a variety of sleep-wake cycle disorders. The most prominent sleep alterations include insomnia as well as excessive daytime sleepiness...
February 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28144228/the-influence-of-dis-belief-in-free-will-on-immoral-behavior
#17
Emilie A Caspar, Laurène Vuillaume, Pedro A Magalhães De Saldanha da Gama, Axel Cleeremans
One of the hallmarks of human existence is that we all hold beliefs that determine how we act. Amongst such beliefs, the idea that we are endowed with free will appears to be linked to prosocial behaviors, probably by enhancing the feeling of responsibility of individuals over their own actions. However, such effects appear to be more complex that one might have initially thought. Here, we aimed at exploring how induced disbeliefs in free will impact the sense of agency over the consequences of one's own actions in a paradigm that engages morality...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28131889/a-neural-network-that-links-brain-function-white-matter-structure-and-risky-behavior
#18
Milky Kohno, Angelica M Morales, Zoe Guttman, Edythe D London
The ability to evaluate the balance between risk and reward and to adjust behavior accordingly is fundamental to adaptive decision-making. Although brain-imaging studies consistently have shown involvement of the dorsolateral prefrontal cortex, anterior insula and striatum during risky decision-making, activation in a neural network formed by these regions has not been linked to structural connectivity. Therefore, in this study, white-matter connectivity was measured with diffusion-weighted imaging in 40 healthy research participants who performed the Balloon Analogue Risk Task, a test of risky decision-making, during fMRI...
January 25, 2017: NeuroImage
https://www.readbyqxmd.com/read/28129259/rationale-for-spiritually-oriented-cognitive-processing-therapy-for-moral-injury-in-active-duty-military-and-veterans-with-posttraumatic-stress-disorder
#19
Harold G Koenig, Nathan A Boucher, Rev John P Oliver, Nagy Youssef, Scott R Mooney, Joseph M Currier, Michelle Pearce
Wartime experiences have long been known to cause ethical conflict, guilt, self-condemnation, difficulty forgiving, loss of trust, lack of meaning and purpose, and spiritual struggles. "Moral injury" (MI) (also sometimes called "inner conflict") is the term used to capture this emotional, cognitive, and behavioral state. In this article, we provide rationale for developing and testing Spiritually Oriented Cognitive Processing Therapy, a version of standard cognitive processing therapy for the treatment of MI in active duty and veteran service members (SMs) with posttraumatic stress disorder symptoms who are spiritual or religious (S/R)...
February 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28122657/challenges-and-opportunities-to-engaging-emergency-medical-service-providers-in-substance-use-research-a-qualitative-study
#20
Allysha C Maragh-Bass, Julie C Fields, Junette McWilliams, Amy R Knowlton
: Introduction Research suggests Emergency Medical Services (EMS) over-use in urban cities is partly due to substance users with limited access to medical/social services. Recent efforts to deliver brief, motivational messages to encourage these individuals to enter treatment have not considered EMS providers. Problem Little research has been done with EMS providers who serve substance-using patients. The EMS providers were interviewed about participating in a pilot program where they would be trained to screen their patients for substance abuse and encourage them to enter drug treatment...
January 26, 2017: Prehospital and Disaster Medicine
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