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https://www.readbyqxmd.com/read/29334315/interplay-between-p53-and-ink4c-in-spermatogenesis-and-fertility
#1
Hassan Zalzali, Wisam Rabeh, Omar Najjar, Rami Abi Ammar, Mohamad Harajly, Raya Saab
The tumor suppressor p53, and the cyclin-dependent kinase inhibitor Ink4c, have been both implicated in spermatogenesis control. Both p53-/- and Ink4c-/- single knockout male mice are fertile, despite testicular hypertrophy, Leydig cell differentiation defect, and increased sperm count in Ink4c-/- males. To investigate their collaborative roles, we studied p53-/- Ink4c-/- dual knockout animals, and found that male p53-/- Ink4c-/- mice have profoundly reduced fertility. Dual knockout male mice show a marked decrease in sperm count, abnormal sperm morphology and motility, prolongation of spermatozoa proliferation and delay of meiosis entry, and accumulation of DNA damage...
January 15, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29332617/decontamination-of-extracorporeal-membrane-oxygenator-devices-with-an-intensified-disinfection-protocol-how-strict-is-too-strict
#2
Rami Sommerstein, Tobias M Merz, Stephan M Jakob, Jukka Takala, Jonas Marschall
No abstract text is available yet for this article.
January 15, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29331635/sotatercept-with-long-term-extension-for-the-treatment-of-anaemia-in-patients-with-lower-risk-myelodysplastic-syndromes-a-phase-2-dose-ranging-trial
#3
Rami Komrokji, Guillermo Garcia-Manero, Lionel Ades, Thomas Prebet, David P Steensma, Joseph G Jurcic, Mikkael A Sekeres, Jesus Berdeja, Michael R Savona, Odile Beyne-Rauzy, Aspasia Stamatoullas, Amy E DeZern, Jacques Delaunay, Gautam Borthakur, Robert Rifkin, Thomas E Boyd, Abderrhamane Laadem, Bond Vo, Jennie Zhang, Marie Puccio-Pick, Kenneth M Attie, Pierre Fenaux, Alan F List
BACKGROUND: Myelodysplastic syndromes are characterised by ineffective erythropoiesis leading to anaemia. Sotatercept (ACE-011) is a novel activin receptor type IIA fusion protein that acts as a ligand trap to neutralise negative regulators of late-stage erythropoiesis. The aim of the study was to establish a safe and effective dose of sotatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes. METHODS: This open-label, multicentre, dose-ranging, phase 2 trial took place at 11 treatment centres in the USA and France...
January 10, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29331034/effects-of-in-situ-selenium-exposure-and-maternal-transfer-on-survival-and-deformities-of-brown-trout-salmo-trutta-fry
#4
Sean M Covington, Rami B Naddy, Alan L Prouty, Steven A Werner, Mark Dunn Lewis
Offspring of wild adult brown trout exposed to a range of selenium (Se) concentrations were reared in a laboratory setting to primarily assess effects on survival and deformities. Maternal whole body Se concentrations ranged from 4.7 to 22.6 mg/kg dry weight (dw) for wild fish. Corresponding Se concentrations in embryos ranged from 6.2 to 40.3 mg/kg dw. Significant relationships were found between embryo and whole-body tissue concentrations. Increasing egg Se concentrations were correlated with decreasing survival; however, hatch success was not significantly correlated with increasing embryo Se...
January 13, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29329133/cutaneous-angiosarcoma-of-the-eyelid-mimicking-morbihan-disease
#5
Donna C Ferguson, Louise A Mawn, Rami N Al-Rohil
BACKGROUND: Cutaneous angiosarcoma presents clinically in numerous ways, and can be mistaken for a different clinical entity, particularly when arising at unusual anatomic locations such as the eyelid. CASE PRESENTATION: A 57-year-old woman presented with a 1-year history of eyelid swelling. Concurrent imaging was also suggestive of an edematous process. Multiple superficial biopsies showed nonspecific dermal inflammation and interstitial edema. A diagnosis of Morbihan disease (chronic and idiopathic lymphedema of the eyelid) was rendered, and the patient was treated with compression and local therapy without clinical improvement...
January 11, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29328936/pyrolysis-and-reutilization-of-plant-residues-after-phytoremediation-of-heavy-metals-contaminated-sediments-for-heavy-metals-stabilization-and-dye-adsorption
#6
Xiaomin Gong, Danlian Huang, Yunguo Liu, Guangming Zeng, Rongzhong Wang, Jingjing Wei, Chao Huang, Piao Xu, Jia Wan, Chen Zhang
This study aimed to investigate the effect of pyrolysis on the stabilization of heavy metals in plant residues obtained after phytoremediation. Ramie residues, being collected after phytoremediation of metal contaminated sediments, were pyrolyzed at different temperatures (300-700 °C). Results indicated that pyrolysis was effective in the stabilization of Cd, Cr, Zn, Cu, and Pb in ramie residues by converting the acid-soluble fraction of metals into residual form and decreasing the TCLP-leachable metal contents...
January 5, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29328605/third-dose-of-mmr-vaccine-for-mumps-control
#7
Philipp Jent, Andreas Olah, Rami Sommerstein
No abstract text is available yet for this article.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29327379/influence-of-varying-stem-and-metaphyseal-sleeve-size-on-the-primary-stability-of-cementless-revision-tibial-trays-used-to-reconstruct-aori-iia-defects-a-simulation-study
#8
Maged Awadalla, Rami M A Al-Dirini, Dermot O'Rourke, Lucian Bogdan Solomon, Mark Heldreth, Mark Taylor
Traditionally, diaphyseal stems have been utilized to augment the stability of revision total knee replacement (rTKR) implants. More recently metaphyseal augments, such as sleeves, have been introduced to further augment component fixation. The effect of augments such as stems and sleeves have on the primary stability of a rTKR implant is poorly understood, however it has important implications on the complexity, costs and survivorship of the procedure. Finite element analysis was used to investigate the primary stability and strain distribution of various size stems and sleeves used in conjunction with a cementless revision tibial tray...
January 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29326062/functional-effects-of-an-interpenetrating-polymer-network-on-articular-cartilage-mechanical-properties
#9
Janne Ta Mäkelä, Benjamin G Cooper, Rami K Korhonen, Mark W Grinstaff, Brian D Snyder
OBJECTIVE: Depletion of glycosaminoglycans (GAGs) and degradation of collagen network are early hallmarks of osteoarthritis. Currently, there are no chondroprotective therapies that mitigate the loss of GAGs or effectively restore the collagen network. Recently, a novel polymeric cartilage supplement was described that forms a charged interpenetrating polymer network (IPN) reconstituting the hydrophilic properties of the extracellular matrix. To investigate the mechanism by which this hydrophilic IPN improves articular cartilage material properties, a finite element (FE) model is used to evaluate the IPN's effect on the fibrillar collagen network, nonfibrillar matrix, and interstitial fluid flow...
January 8, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29321231/chronic-traumatic-encephalopathy-in-an-epilepsy-surgery-cohort-clinical-and-pathologic-findings
#10
Amy L Jones, Jeffrey W Britton, Melissa M Blessing, Joseph E Parisi, Gregory D Cascino
OBJECTIVE: To determine the occurrence of chronic traumatic encephalopathy (CTE) in young adult patients undergoing epilepsy surgery. METHODS: Ten patients who underwent epilepsy surgery were randomly selected for this retrospective study. The patients were 18-45 years of age, had preoperative neuropsychological evaluation, and had 1 year postoperative follow-up. Microscopic sections from resections were evaluated for the presence of CTE with standard stains and antibodies to tau (clone AT8)...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29316568/effect-of-submerged-vs-nonsubmerged-implant-placement-protocols-on-implant-failure-and-marginal-bone-loss-a-systematic-review-and-meta-analysis
#11
Ramy Moustafa Moustafa Ali, Ahmed Yaseen Alqutaibi, Amr Salah El-Din Gomaa, Mohamed Farouk Abdallah
PURPOSE: To compare prosthesis and implant failures and marginal bone loss (MBL) resulting from submerged vs nonsubmerged dental implant protocols. MATERIALS AND METHODS: Electronic and manual searches of two databases (MEDLINE [PubMed] and Cochrane) were conducted to identify randomized controlled trials (RCTs) comparing submerged to nonsubmerged dental implant protocols. Data were independently extracted by two reviewers, and meta-analyses were performed for the included RCTs...
January 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29315371/computed-tomography-characteristics-of-the-aortic-valve-and-the-geometry-of-sapien-3-transcatheter-heart-valve-in-patients-with-bicuspid-aortic-valve-disease
#12
Hiroyuki Kawamori, Sung-Han Yoon, Tarun Chakravarty, Yoshio Maeno, Mohammad Kashif, Sharjeel Israr, Yigal Abramowitz, Geeteshwar Mangat, Masaki Miyasaka, Tanya Rami, Yoshio Kazuno, Nobuyuki Takahashi, Hasan Jilaihawi, Mamoo Nakamura, Wen Cheng, John Friedman, Daniel Berman, Rahul Sharma, Raj R Makkar
Aims: We assessed the geometry of transcatheter heart valve (THV) and valve function associated with SAPIEN 3 implantation in patients with bicuspid aortic valve (BAV) stenosis. Methods and results: We included 280 consecutive patients who had a contrast computed tomography (CT) before and after transcatheter aortic valve implantation (TAVI) in our institution. Each THV was assessed by CT at five cross-sectional levels: inflow, annulus, mid, sinus, and outflow. The geometry of THV was assessed for eccentricity (1 - minimum diameter/maximum diameter) and expansion (CT derived external valve area/nominal external valve area)...
January 5, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29313526/fundamental-principles-in-bacterial-physiology-history-recent-progress-and-the-future-with-focus-on-cell-size-control-a-review
#13
Suckjoon Jun, Fangwei Si, Rami Pugatch, Matthew Scott
Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology. This article is divided into two parts...
January 9, 2018: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29313277/does-sleeve-shape-make-a-difference-in-outcomes
#14
Adel Alhaj Saleh, Michal R Janik, Rami R Mustafa, Mohammed Alshehri, Adil H Khan, Seyed Mohammad Kalantar Motamedi, Shiraz Rahim, Indravadan Patel, Amir Aryaie, Mujjahid Abbas, Tomasz Rogula, Leena Khaitan
INTRODUCTION: Sleeve gastrectomy (SG) is one of the most common procedures performed for weight loss. Many seek the "perfect sleeve" with the notion that the type of calibrating device affects sleeve shape, and this in turn will affect outcomes and complications. Two major concerns after SG are amount of weight loss and acid reflux. Our aim was to determine if the various calibration methods could impact sleeve shape and thereby allow for better outcomes of weight loss and reflux. METHODS: A retrospective chart review was performed of 210 patients who underwent SG and had postoperative upper gastrointestinal (UGI) study from 2011 to 2015 in a single center by a single (fellowship-trained) bariatric surgeon...
January 8, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29312662/is-there-a-safe-time-to-stop-clopidogrel-in-patients-on-dual-antiplatelet-therapy-after-a-percutaneous-coronary-intervention-and-placement-of-drug-eluting-stents
#15
EDITORIAL
Nureddin Almaddah, Rami N Khouzam
No abstract text is available yet for this article.
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311693/combined-shrna-over-crispr-cas9-as-a-methodology-to-detect-off-target-effects-and-a-potential-compensatory-mechanism
#16
Liat Peretz, Elazar Besser, Renana Hajbi, Natania Casden, Dan Ziv, Nechama Kronenberg, Liat Ben Gigi, Sahar Sweetat, Saleh Khawaled, Rami Aqeilan, Oded Behar
Inhibition of genes is a powerful approach to study their function. While RNA interference is a widely used method to achieve this goal, mounting evidence indicates that such an approach is prone to off-target effects. An alternative approach to gene function inhibition is genetic mutation, such as the CRISPR/cas9 method. A recent report, however, demonstrated that genetic mutation and inhibition of gene expression do not always give corresponding results. This can be explained by off-target effects, but it was recently shown, at least in one case, that these differences are the result of a compensatory mechanism induced only by genetic mutation...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303927/preoperative-prediction-of-lymph-nodal-metastases-in-endometrial-carcinoma-is-it-possible-a-literature-review
#17
Rami Fares, Sean Kehoe, Nazem Shams
BACKGROUND: Lymph node status is one of the most important prognostic factors in endometrial cancer and crucial for deciding adjuvant therapy. OBJECTIVE: The aim of the study was to assess the different models used to predict lymphatic nodal disease. SEARCH STRATEGY: A literature search was conducted to detect the relevant studies. INCLUSION CRITERIA: Relevant papers comparing the preoperative modality with the final histopathological results including randomized clinical trials, case-control studies, and any publications with a minimum of 50 patients in the report...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29303567/stereoselective-dynamic-cyclization-of-allylic-azides-synthesis-of-tetralins-chromanes-and-tetrahydroquinolines
#18
Matthew R Porter, Rami M Shaker, Cristian Calcanas, Joseph J Topczewski
This report describes the stereoselective synthesis of 3-azido-tetralins, -chromanes, and -tetrahydroquinolines via a tandem allylic azide rearrangement/Friedel-Crafts alkylation. Exposure of allylic azides with a pendant trichloroacetimidate to catalytic quantities of AgSbF6 proved optimal for this transformation. This cascade suc-cessfully differentiates the equilibrating azide isomers, providing products in excellent yield and selectivity (>25 examples, up to 94% yield and >25:1 dr). In many cases, the reactive isomer is only a trace fraction of the equilibrium mixture, keenly illustrating the dynamic nature of these systems...
January 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29300708/medial-open-transversus-abdominis-plane-motap-catheters-reduce-opioid-requirements-and-improve-pain-control-following-open-liver-resection-a-multicenter-blinded-randomized-controlled-trial
#19
Paul Jack Karanicolas, Sean Cleary, Paul McHardy, Alex Kiss, Jason Sawyer, Ramy Behman, Salima Ladak, Stuart A McCluskey, Coimbatore Srinivas, Joel Katz, Natalie Coburn, Calvin Law, Alice C Wei, Paul Greig, Julie Hallet, Hance Clarke
OBJECTIVE: Conventional management of pain following open liver resection involves intravenous, patient-controlled analgesia (IV PCA) or epidural analgesia. The objective of this trial was to assess the efficacy of a regional technique called Medial Open Transversus Abdominis Plane (MOTAP) catheter analgesia compared with IV PCA. METHODS: This was a blinded, randomized, controlled parallel-arm trial conducted at 2 high-volume centers. Patients undergoing liver resection through a subcostal incision were enrolled...
January 3, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29296031/dextromethorphan-in-cough-syrup-the-poor-man-s-psychosis
#20
Bridgette Martinak, Ramy A Bolis, Jeffrey Ryne Black, Rachel E Fargason, Badari Birur
Dextromethorphan (3-methoxy-N-methylmorphinan), also known as "DXM" and "the poor man's PCP," is a synthetically produced drug that is available in more than 140 over-the-counter cough and cold preparations. Dextromethorphan (DXM) has overtaken codeine as the most widely used cough suppressant due to its availability, efficacy, and safety profile at directed doses. However, DXM is subject to abuse. When consumed at inappropriately high doses (over 1500 mg/day), DXM can induce a state of psychosis characterized by Phencyclidine (PCP)-like psychological symptoms, including delusions, hallucinations, and paranoia...
September 15, 2017: Psychopharmacology Bulletin
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