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https://www.readbyqxmd.com/read/28654538/our-first-simulator-a-fond-farewell
#1
Rami Ahmed
No abstract text is available yet for this article.
July 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28653271/regadenoson-use-in-chronic-kidney-disease-and-end-stage-renal-disease-a-focused-review
#2
Aviral Vij, Yasmeen Golzar, Rami Doukky
Regadenoson is a selective A2A adenosine receptor agonist that has been approved as a vasodilator stress agent with single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI). Since its approval by the Food and Drug Administration (FDA) in 2008, it has become the most commonly used pharmacologic stress agent with SPECT-MPI. Given that it is predominantly renally excreted, its use in patients with chronic kidney disease has been the subject of active post-marketing clinical research...
June 26, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28653008/comments-on-liver-resection-using-total-vascular-exclusion-of-the-liver-preserving-the-caval-flow-in-situ-hypothermic-portal-perfusion-and-temporary-porta-caval-shunt-a-new-technique-for-central-tumors
#3
COMMENT
Daniele Sommacale, Rami Rhaiem, Tullio Piardi, Audrey Cagniet, Reza Kianmanesh
No abstract text is available yet for this article.
June 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28652355/neural-mechanism-for-hypothalamic-mediated-autonomic-responses-to-light-during-migraine
#4
Rodrigo Noseda, Alice J Lee, Rony-Reuven Nir, Carolyn A Bernstein, Vanessa M Kainz, Suzanne M Bertisch, Catherine Buettner, David Borsook, Rami Burstein
Migraineurs avoid light because it intensifies their headache. However, this is not the only reason for their aversion to light. Studying migraineurs and control subjects, we found that lights triggered more changes in autonomic functions and negative emotions during, rather than in the absence of, migraine or in control subjects, and that the association between light and positive emotions was stronger in control subjects than migraineurs. Seeking to define a neuroanatomical substrate for these findings, we showed that, in rats, axons of retinal ganglion cells converge on hypothalamic neurons that project directly to nuclei in the brainstem and spinal cord that regulate parasympathetic and sympathetic functions and contain dopamine, histamine, orexin, melanin-concentrating hormone, oxytocin, and vasopressin...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28652246/mapk-signaling-and-inflammation-link-melanoma-phenotype-switching-to-induction-of-cd73-during-immunotherapy
#5
Julia Reinhardt, Jennifer Landsberg, Jonathan L Schmid-Burgk, Bartomeu Bibiloni Ramis, Tobias Bald, Nicole Glodde, Dorys Lopez-Ramos, Arabella Young, Shin Foong Ngiow, Daniel Nettersheim, Hubert Schorle, Thomas Quast, Waldemar Kolanus, Dirk Schadendorf, Georgina V Long, Jason Madore, Richard A Scolyer, Antoni Ribas, Mark J Smyth, Paul C Tumeh, Thomas Tuting, Michael Hölzel
Evolution of tumor cell phenotypes promotes heterogeneity and therapy resistance. Here we found that induction of CD73, the enzyme that generates immunosuppressive adenosine, is linked to melanoma phenotype switching. Activating MAPK mutations and growth factors drove CD73 expression, which marked both nascent and full activation of a mesenchymal-like melanoma cell state program. Proinflammatory cytokines like TNF-alpha cooperated with MAPK signaling through the c-Jun/AP-1 transcription factor complex to activate CD73 transcription by binding to an intronic enhancer...
June 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28652159/skin-to-tumor-distance-predicts-treatment-failure-of-t1a-renal-cell-carcinoma-following-percutaneous-cryoablation
#6
Simone L Vernez, Zhamshid Okhunov, Kamaljot Kaler, Ramy F Youssef, Rahul Dutta, Arkadiy Palvanov, Paras Shah, Kathryn Osann, David N Siegel, Igor Lobko, Louis Kavoussi, Ralph V Clayman, Jaime Landman
OBJECTIVE: To determine the impact of skin-to-tumor (STT) distance on the risk for treatment failure following PCA. METHODS: We retrospectively reviewed patients who underwent PCA with documented T1a recurrent renal cell carcinoma (RCC) at two academic centers between 2005 and 2015. Patient demographics, tumor characteristics, perioperative and post-operative course variables were collected. Additionally, we measured the STT by averaging the distance from the skin to the center of the tumor at 0, 45 and 90 degrees on preoperative computed tomography imaging...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28651885/use-of-antibiotic-beads-to-salvage-infected-breast-implants
#7
Rami D Sherif, Michael Ingargiola, Paymon Sanati-Mehrizy, Philip J Torina, Marco A Harmaty
PURPOSE: When an implant becomes infected, implant salvage is often performed where the implant is removed, capsulectomy is performed, and a new implant is inserted. The patient is discharged with a PICC line and 6-8 weeks of intravenous (IV) antibiotics. This method has variable success and subjects the patient to long-term systemic antibiotics. In the 1960s, the use of antibiotic-impregnated beads for the treatment of chronic osteomyelitis was described. These beads deliver antibiotic directly to the site of the infection, thereby eliminating the complications of systemic IV antibiotics...
May 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28649381/new-cancer-immunotherapy-agents-in-development-a-report-from-an-associated-program-of-the-31-st-annual-meeting-of-the-society-for-immunotherapy-of-cancer-2016
#8
REVIEW
Prasad S Adusumilli, Edward Cha, Mark Cornfeld, Thomas Davis, Adi Diab, Thomas W Dubensky, Elizabeth Evans, Jane L Grogan, Bryan A Irving, Rom S Leidner, Shane A Olwill, Patrick Soon-Shiong, Frederic Triebel, David Tuck, Adrian Bot, Roger D Dansey, Charles G Drake, Gordon J Freeman, Ramy Ibrahim, Salil Patel, Daniel S Chen
This report is a summary of 'New Cancer Immunotherapy Agents in Development' program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28648932/federal-travel-restrictions-to-prevent-disease-transmission-in-the-united-states-an-analysis-of-requested-travel-restrictions
#9
M Robynne Jungerman, Laura A Vonnahme, Faith Washburn, Francisco Alvarado-Ramy
BACKGROUND: Individuals with certain communicable diseases may pose risks to the health of the traveling public; there has been documented transmission on commercial aircraft of tuberculosis (TB), measles, and severe acute respiratory syndrome (SARS). Federal public health travel restrictions (PHTR) prevent commercial air or international travel of persons with communicable diseases that pose a public health threat. METHODS: We described demographics and clinical characteristics of all cases considered for PHTR because of suspected or confirmed communicable disease from May 22, 2007, to December 31, 2015...
June 22, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28648920/ultrasound-assessment-of-human-meniscus
#10
Tuomas Viren, Juuso T Honkanen, Elvis K Danso, Lassi Rieppo, Rami K Korhonen, Juha Töyräs
The aim of the present study was to evaluate the applicability of ultrasound imaging to quantitative assessment of human meniscus in vitro. Meniscus samples (n = 26) were harvested from 13 knee joints of non-arthritic human cadavers. Subsequently, three locations (anterior, center and posterior) from each meniscus were imaged with two ultrasound transducers (frequencies 9 and 40 MHz), and quantitative ultrasound parameters were determined. Furthermore, partial-least-squares regression analysis was applied for ultrasound signal to determine the relations between ultrasound scattering and meniscus integrity...
June 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28646644/a-systematic-review-to-uncover-a-universal-protocol-for-accuracy-assessment-of-3-dimensional-virtually-planned-orthognathic-surgery
#11
REVIEW
Ramy M Gaber, Eman Shaheen, Bart Falter, Sebastian Araya, Constantinus Politis, Gwen R J Swennen, Reinhilde Jacobs
PURPOSE: The aim of this study was to systematically review methods used for assessing the accuracy of 3-dimensional virtually planned orthognathic surgery in an attempt to reach an objective assessment protocol that could be universally used. MATERIALS AND METHODS: A systematic review of the currently available literature, published until December 9, 2016, was conducted using PubMed as the primary search engine. We performed secondary searches using the Cochrane Database, clinical trial registries, Google Scholar, and Embase, as well as a bibliography search...
June 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28646180/sustained-release-from-a-metal-analgesics-entrapped-within-biocidal-silver
#12
Barak Menagen, Rami Pedahzur, David Avnir
Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646027/revisiting-protein-acetylation-and-myocardial-fatty-acid-oxidation
#13
Rami Al Batran, John R Ussher
N/A.
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28645955/is-there-an-ethnic-variation-in-the-epidemiology-of-gonorrhoea-a-retrospective-population-based-study-from-northern-israel-over-15%C3%A2-years-between-2001-and-2015
#14
Khalaf Kridin, Rami Grifat, Mogher Khamaisi
OBJECTIVE: To investigate the trends in the incidence of gonorrhoea through an extended period of time and to compare the epidemiology of gonorrhoea infection between 2 distinct ethnic groups (Jews and Arabs). DESIGN: A retrospective population-based cohort study was conducted on all consecutive patients diagnosed with gonorrhoea through the years 2001-2015. SETTING: National Department of Epidemiology of the Ministry of Health, Haifa District, Israel...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645118/outcome-of-patients-treated-for-myelodysplastic-syndromes-with-5q-deletion-after-failure-of-lenalidomide-therapy
#15
Thomas Prebet, Thomas Cluzeau, Sophie Park, Mikkael A Sekeres, Ulrich Germing, Lionel Ades, Uwe Platzbecker, Katharina Gotze, Norbert Vey, Esther Oliva, Mary M Sugrue, Cecile Bally, Charikleia Kelaidi, Najla Al Ali, Pierre Fenaux, Steven D Gore, Rami Komrokji
While lenalidomide (LEN) is the standard of care for the lower-risk myelodysplastic syndromes (MDS) patients with deletion 5q, 35% will not respond to or do not tolerate the drug. Moreover, most of the patients will lose their response after a few years. Defining the outcome of patients with LEN failure and determining the impact of subsequent therapies is therefore important to develop alternative strategies. Based on an international collaboration, we were able to compile a total of 392 patient cases of lower-risk MDS patients with 5q deletion and to analyze their outcome after failure of lenalidomide...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28643733/a-prospective-randomized-controlled-study-of-cisplatin-versus-carboplatin-based-regimen-in-advanced-squamous-nonsmall-cell-lung-cancer
#16
Amr Shafik Saad, Ramy R Ghali, May Ahmed Shawki
BACKGROUND: The use of cisplatin (Cis) versus carboplatin (Carb) in the treatment of advanced nonsmall cell lung cancer (NSCLC) is controversial. The aim of the study was to compare the safety and efficacy of Cis versus Carb in squamous NSCLC. PATIENTS AND METHODS: A prospective, randomized, controlled, open-label study was conducted on advanced squamous NSCLC patients who were randomly assigned to receive Cis (40 mg/m 2 [day 1 and day 8]) or Carb (area under the curve = 5 [day 1]) combined with gemcitabine [Gem] (1000 mg/m 2 [day 1 and day 8]) of a 3-week schedule for six cycles...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28642283/selective-inhibition-of-trigeminovascular-neurons-by-fremanezumab-a-humanized-monoclonal-anti-cgrp-antibody
#17
Agustin Melo-Carrillo, Rodrigo Noseda, Rony Nir, Aaron Schain, Jennifer Stratton, Andrew M Strassman, Rami Burstein
A large body of evidence supports an important role for CGRP in migraine pathophysiology. This evidence gave rise to a global effort to develop a new generation of therapeutics that inhibit the interaction of CGRP with its receptor in migraineurs. Recently, a new class of such drugs, humanized monoclonal anti-CGRP antibodies (CGRP-mAb) were found to be effective in reducing the frequency of migraine. The purpose of this study was to better understand how the CGRP-mAb fremanezumab (TEV-48125) modulates meningeal sensory pathways...
June 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28638693/management-of-the-temporomandibular-joint-in-inflammatory-arthritis-involvement-of-surgical-procedures
#18
REVIEW
Rory C O'Connor, Fiona Fawthrop, Rami Salha, Andrew J Sidebottom
Many conditions may affect the temporomandibular joint (TMJ), but its incidence in individual joint diseases is low. However, inflammatory arthropathies, particularly rheumatoid and psoriatic arthritis and ankylosing spondylitis, appear to have a propensity for affecting the joint. Symptoms include pain, restriction in mouth opening, locking, and noises, which together can lead to significant impairment. Jaw rest, a soft diet, a bite splint, and medical therapy, including disease-modifying antirheumatic drugs (DMARDs) and simple analgesia, are the bedrock of initial treatment and will improve most symptoms in most patients...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28634033/nickel-sulfate-promotes-il-17a-producing-cd4-t-cells-by-an-il-23-dependent-mechanism-regulated-by-tlr4-and-jak-stat-pathways
#19
Rami Bechara, Diane Antonios, Hayat Azouri, Marc Pallardy
Allergic contact dermatitis, caused by nickel, is a delayed-type hypersensitivity reaction and 14.5% of the general population may be affected in Europe. Among a wide range of cytokines, the IL-12 family has unique structural and immunological characteristics. While IL-12p70 promotes T helper (Th) 1 cells polarization, IL-23 promotes Th17 cells development and both have been isolated from nickel-allergic patients. In this work, we were interested in understanding the mechanism behind nickel-induced Th17 cells development...
June 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28633731/image-diagnosis-multivessel-percutaneous-coronary-intervention-in-dextrocardia-success-with-usual-techniques-in-a-case-of-mirror-image-heart
#20
Mohamed Morsy, Pranab Das, Inyong Hwang, Rami N Khouzam
No abstract text is available yet for this article.
2017: Permanente Journal
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