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https://www.readbyqxmd.com/read/28808887/chronic-silymarin-quercetin-and-naringenin-treatments-increase-monoamines-synthesis-and-hippocampal-sirt1-levels-improving-cognition-in-aged-rats
#1
F Sarubbo, M R Ramis, C Kienzer, S Aparicio, S Esteban, A Miralles, D Moranta
Polyphenols have beneficial neurological effects delaying cognitive and motor decline in aging due to their antioxidant, antiinflammatory and neuroprotective properties. These effects could be related to SIRT1 activation (implicated in synaptic plasticity, memory and inflammation) and monoaminergic synthesis modulation. In this work, we studied in old male rats, the in vivo effects of long-term administration of different polyphenols (silymarin, quercetin and naringenin; 20 mg/kg/day i.p, 4 weeks) (Sprague-Dawley, 18 months) on cognition and motor coordination...
August 14, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28807526/the-effect-of-fixed-charge-density-and-cartilage-swelling-on-mechanics-of-knee-joint-cartilage-during-simulated-gait
#2
Lasse P Räsänen, Petri Tanska, Štefan Zbýň, Corrinus C van Donkelaar, Siegfried Trattnig, Miika T Nieminen, Rami K Korhonen
The effect of swelling of articular cartilage, caused by the fixed charge density (FCD) of proteoglycans, has not been demonstrated on knee joint mechanics during simulated walking before. In this study, the influence of the depth-wise variation of FCD was investigated on the internal collagen fibril strains and the mechanical response of the knee joint cartilage during gait using finite element (FE) analysis. The FCD distribution of tibial cartilage was implemented from sodium ((23)Na) MRI into a 3-D FE-model of the knee joint ("Healthy model")...
July 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28807236/overcoming-barriers-to-treating-iron-overload-in-patients-with-lower-risk-myelodysplastic-syndrome
#3
REVIEW
Amer M Zeidan, Vinod A Pullarkat, Rami S Komrokji
Myelodysplastic syndromes (MDS) constitute a group of heterogeneous hematopoietic neoplasms characterized by ineffective erythropoiesis, anemia, and/or cytopenias. Supportive care for patients with MDS involves frequent red blood cell transfusions, which places patients with ongoing transfusional dependence (TD) at risk for iron overload (IO). Development of IO and tissue iron deposition can increase the risk of cardiac, hepatic, and endocrine toxicities, infection, and progression to acute myeloid leukemia...
September 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28806245/gorham-stout-disease-affecting-the-mandible-bone-scintigraphy-and-computed-tomography-findings
#4
Soo Bin Park, Joon Young Choi, Soo Jeong Kim
We present images of a 13-year-old boy with Gorham-Stout disease affecting the mandible. Initial bone scintigraphy showed poor visualization of Tc-methylene diphosphonate (Tc-MDP) uptake in the mandible body. However, abnormally increased Tc-MDP uptake was noted in the bilateral mandibular rami. In the follow-up examination a year later, bone scintigraphy indicated that the disease had progressed to the bilateral mandibular rami with no uptake. In addition, massive osteolysis of the mandible was noted that had progressed since the initial computed tomography...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28805613/a-complicated-urethrovaginal-fistula-following-an-inappropriate-urethral-diverticulum-management
#5
Tsia-Shu Lo, Sukanda Bin Jaili, Rami Ibrahim
OBJECTIVE: Urethral diverticulum is uncommon, therefore appropriate evaluation, preoperative planning and counseling must be done in order to make correct diagnosis and prevent complications. MATERIALS AND METHODS: A case of anterior vaginal wall mass was treated elsewhere by a gynecologist as periurethral cyst abscess; incision and drainage were done but a symptom of pus discharge was observed after 2 weeks. Therefore, exploration, cyst wall excision and primary closure were done though histopathological examination surprisingly confirmed the presence of urethral tissue suggestive of diverticulum...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28804619/knowledge-sharing-in-infection-prevention-in-routine-and-outbreak-situations-a-survey-of-the-society-for-healthcare-epidemiology-of-america-research-network
#6
Rami Sommerstein, Sonja Geser, Andrew Atkinson, Franziska Tschan, Daniel J Morgan, Jonas Marschall
In this cross-sectional Society for Healthcare Epidemiology of America Research Network survey on knowledge sharing in infection prevention we identified a rudimentary understanding of how to communicate and share knowledge within healthcare institutions. Our data support the need of further research in this important field.
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28801898/secreted-reporters-for-monitoring-multiple-promoter-function
#7
Ghazal Lashgari, Rami S Kantar, Bakhos A Tannous
Secreted reporter proteins are reliable modalities for monitoring of different biological processes, which can be measured longitudinally in conditioned medium of cultured cells or body fluids such as blood and urine, ex vivo. In this chapter, we will explore established secreted reporters and their applications and limitations for monitoring of promoter function. We will also describe both cell-based and blood-based assays for detecting three commonly used reporters: secreted alkaline phosphatase (SEAP ), Gaussia luciferase (Gluc), and Vargula luciferase (Vluc)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28799706/outcome-after-transcatheter-occlusion-of-patent-ductus-arteriosus-in-infants-less-than-6-kg-a-national-study-from-united-kingdom-and-ireland
#8
Sok-Leng Kang, Salim Jivanji, Chetan Mehta, Andrew J Tometzki, Graham Derrick, Robert Yates, Sachin Khambadkone, Joseph de Giovanni, Oliver Stumper, Rami Dhillon, Vinay Bhole, Zdenek Slavik, Michael Rigby, Patrick Noonan, Ben Smith, Brodie Knight, Trevor Richens, Neil Wilson, Kevin Walsh, Adam James, John Thomson, Jamie Bentham, Nicholas Hayes, Sajid Nazir, Satish Adwani, Arjamand Shauq, Ram Ramaraj, Christopher Duke, Demetris Taliotis, Vikram Kudumula, San-Fui Yong, Gareth Morgan, Eric Rosenthal, Thomas Krasemann, Shakeel Qureshi, David Crossland, Tony Hermuzi, Robin P Martin
OBJECTIVES: This study aimed to report our national experience with transcatheter patent ductus arteriosus (PDA) occlusion in infants weighing <6 kg. BACKGROUND: The technique of transcatheter PDA closure has evolved in the past two decades and is increasingly used in smaller patients but data on safety and efficacy are limited. METHODS: Patients weighing < 6 kg in whom transcatheter PDA occlusion was attempted in 13 tertiary paediatric cardiology units in the United Kingdom and Ireland were retrospectively analyzed to review the outcome and complications...
August 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28799694/patient-with-a-total-artificial-heart-maintained-on-outpatient-dialysis-while-listed-for-combined-organ-transplant-a-single-center-experience
#9
Ramy M Hanna, Huma Hasnain, Mohammad Kamgar, Mina Hanna, Raffi Minasian, James Wilson
Advanced mechanical circulatory support is increasingly being used with more sophisticated devices that can deliver pulsatile rather than continuous flow. These devices are more portable as well, allowing patients to await cardiac transplantation in an outpatient setting. It is known that patients with renal failure are at increased risk for developing worsening acute kidney injury during implantation of a ventricular assist device (VAD) or more advanced modalities like a total artificial heart (TAH). Dealing with patients who have an implanted TAH who develop renal failure has been a challenge with the majority of such patients having to await a combined cardiac and renal transplant prior to transition to outpatient care...
August 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28796201/enhanced-sensitivity-at-higher-order-exceptional-points
#10
Hossein Hodaei, Absar U Hassan, Steffen Wittek, Hipolito Garcia-Gracia, Ramy El-Ganainy, Demetrios N Christodoulides, Mercedeh Khajavikhan
Non-Hermitian degeneracies, also known as exceptional points, have recently emerged as a new way to engineer the response of open physical systems, that is, those that interact with the environment. They correspond to points in parameter space at which the eigenvalues of the underlying system and the corresponding eigenvectors simultaneously coalesce. In optics, the abrupt nature of the phase transitions that are encountered around exceptional points has been shown to lead to many intriguing phenomena, such as loss-induced transparency, unidirectional invisibility, band merging, topological chirality and laser mode selectivity...
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28795616/the-effects-of-glial-cell-line-derived-neurotrophic-factor-after-spinal-cord-injury
#11
Konstantin Rosich, Bishoy Hanna, Rami K Ibrahim, Daniel Joseph Hellenbrand, Amgad Hanna
Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United States. The use of growth factors is a potential treatment for reducing secondary damage, promoting axon growth and restoring some of the lost function after SCI. Glial cell line-derived neurotrophic factor (GDNF) is an important growth factor, because it can affect both neurons and support cells. Here, we give an in depth review of the previously published literature where GDNF was used to treat SCI. The effects of GDNF have been shown to decrease lesion size, improve allodynia, and regenerate axons in the central nervous system and peripheral nervous system...
August 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28794277/modulation-of-social-space-by-dopamine-in-drosophila-melanogaster-but-no-effect-on-the-avoidance-of-the-drosophila-stress-odorant
#12
Robert W Fernandez, Adesanya A Akinleye, Marat Nurilov, Omar Feliciano, Matthew Lollar, Rami R Aijuri, Janis M O'Donnell, Anne F Simon
Appropriate response to others is necessary for social interactions. Yet little is known about how neurotransmitters regulate attractive and repulsive social cues. Using genetic and pharmacological manipulations in Drosophila melanogaster, we show that dopamine is contributing the response to others in a social group, specifically, social spacing, but not the avoidance of odours released by stressed flies (dSO). Interestingly, this dopamine-mediated behaviour is prominent only in the day-time, and its effect varies depending on tissue, sex and type of manipulation...
August 2017: Biology Letters
https://www.readbyqxmd.com/read/28782350/rate-of-teenage-pregnancy-in-jordan-and-its-impact-on-maternal-and-neonatal-outcomes
#13
Yousef S Khader, Anwar Batieha, Rana Kareem Al Fursan, Rami Al-Hader, Sa'ad S Hijazi
Objective Research regarding the adverse outcomes of adolescent childbearing has suffered from many limitations such as a small sample size and non-representative samples. This study was conducted to determine the rate of teenage pregnancy among Jordanian adolescents and its associated adverse maternal and neonatal outcomes. Methods The study is a part of a comprehensive national study of perinatal mortality that was conducted between 2011 and 2012 in Jordan. All women who gave birth after 20 weeks of gestation in 18 maternity hospitals in Jordan between 2011 and 2012 were invited to participate in the study...
July 26, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28780626/prospective-controlled-assessment-of-men-s-sexual-function-changes-following-holmium-laser-enucleation-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia
#14
Ahmed M Elshal, Ahmed El-Assmy, Ramy Mekkawy, Diaa-Eldin Taha, Ahmed R El-Nahas, Mahmoud Laymon, Hamdy El-Kappany, El-Housseiny Ibrahiem
OBJECTIVES: To assess how much Holmium laser enucleation of the prostate (HoLEP) is detrimental on men sexuality. METHODS: Between January and December 2013, all patients presented for BPH surgery were assessed using IIEF-15 (international index of erectile function-15) and Ej-MSHQ (ejaculatory domain-male sexual health questionnaire). Changes in men's sexuality following HoLEP in relation to control procedure were prospectively assessed. Intervention group included legible consecutive patients treated by HoLEP...
August 5, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28774880/a-randomized-phase-ii-study-of-low-dose-decitabine-versus-low-dose-azacitidine-in-lower-risk-mds-and-mds-mpn
#15
Elias Jabbour, Nicholas J Short, Guillermo Montalban-Bravo, Xuelin Huang, Carlos Bueso-Ramos, Wei Qiao, Hui Yang, Chong Zhao, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Koji Sasaki, Zeev Estrov, Jorge Cortes, Farhad Ravandi, Yesid Alvarado, Rami Komrokji, Mikkael A Sekeres, David P Steensma, Amy DeZern, Gail Roboz, Hagop Kantarjian, Guillermo Garcia-Manero
BACKGROUND: Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We compared the safety and efficacy of low-dose decitabine versus low-dose azacitidine in this group of patients. METHODS: Adults with low- or intermediate-1-risk MDS or MDS/myeloproliferative neoplasm (MPN), including chronic myelomonocytic leukemia, by the International Prognostic Scoring System were randomized using a Bayesian adaptive design to receive either azacitidine 75 mg/m(2) IV/SC daily or decitabine 20 mg/m(2) IV daily for 3 consecutive days on a 28-day cycle...
August 3, 2017: Blood
https://www.readbyqxmd.com/read/28773097/dealloyed-ruthenium-film-catalysts-for-hydrogen-generation-from-chemical-hydrides
#16
Ramis B Serin, Nazrin Abdullayeva, Mehmet Sankir
Thin-film ruthenium (Ru) and copper (Cu) binary alloys have been prepared on a Teflon™ backing layer by cosputtering of the precious and nonprecious metals, respectively. Alloys were then selectively dealloyed by sulfuric acid as an etchant, and their hydrogen generation catalysts performances were evaluated. Sputtering time and power of Cu atoms have been varied in order to tailor the hydrogen generation performances. Similarly, dealloying time and the sulfuric acid concentration have also been altered to tune the morphologies of the resulted films...
July 2, 2017: Materials
https://www.readbyqxmd.com/read/28769625/two-new-species-of-leptopsyllus-from-korea-copepoda-harpacticoida-paramesochridae
#17
Jinwook Back, Wonchoel Lee
Two new species of Leptopsyllus are described from the subtidal zone of Korea. Both species were assigned to the subgenus Leptopsyllus (Leptopsyllus) T. Scott, 1894, based on following three characters: two-segmented rami of P1, absence of endopod on P2 and P3, and presence of one-segmented endopod of P4. L. (L.) pundius sp. n. is most closely related to L. (L.) punctatus Mielke, 1894, however clearly distinguishable from it based on mandibular exopod with two setae, shape of P6, and caudal seta III ornamented with spinules in the new species...
2017: ZooKeys
https://www.readbyqxmd.com/read/28764841/non-st-elevation-acute-coronary-syndromes-a-comprehensive-review
#18
Tamunoinemi Bob-Manuel, Ikechuckwu Ifedili, Guy Reed, Uzoma N Ibebuogu, Rami N Khouzam
Non-ST elevation-acute coronary syndrome (NSTE-ACS) includes NSTE myocardial infarction and unstable angina. This patient population forms approximately two-thirds of all hospital admissions for ACS in the United States each year and is associated with an in-hospital mortality of 5%. NSTE-ACS is primarily due to an acute change in the supply and demand balance of coronary perfusion and myocardial oxygen consumption, because of the significant coronary artery obstruction presenting as plaque rupture or erosion...
September 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/28761032/influence-of-knowledge-and-beliefs-on-consumption-of-performance-enhancing-agents-in-north-western-saudi-arabia
#19
Omar Mansour Al, Rami Azmi Elshatarat
BACKGROUND: Consumption of performance enhancing agents (PEAs) has a wide range of negative health consequences, but knowledge of these consequences among gym users of PEAs in Saudi Arabia is not well understood. OBJECTIVES: Identify the knowledge, awareness, beliefs and attitudes of gym users about negative health consequences of using PEAs, and the relationship between these factors and use of these agents. DESIGN: Cross-sectional study...
July 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28760463/survival-after-esophagectomy-a-propensity-matched-study-of-different-surgical-approaches
#20
Benny Weksler, Jennifer L Sullivan
BACKGROUND: Although open esophagectomy (OE) is considered the "gold standard" treatment for esophageal cancer, robotic-assisted minimally invasive esophagectomy (RAMIE), and laparoscopic/thoracoscopic minimally invasive esophagectomy (MIE) are becoming more common. This study aimed to compare short-term outcomes and overall survival of patients undergoing RAMIE, MIE, and OE. METHODS: The National Cancer Data Base was queried for patients who had OE, RAMIE, or MIE for esophageal cancer from 2010 to 2013...
July 28, 2017: Annals of Thoracic Surgery
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